locus-tag	class	description
AFERRID_RS00020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AFERRID_RS00065	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFERRID_RS00105	COG1104	cysteine desulfurase activity
AFERRID_RS00130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AFERRID_RS00145	COG3451	type IV secretory pathway VirB4
AFERRID_RS00150	COG5268	conjugation
AFERRID_RS00155	COG3838	Conjugal transfer protein Trbc
AFERRID_RS00165	COG4962	Type ii secretion system protein e
AFERRID_RS00195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AFERRID_RS00275	COG0531	amino acid
AFERRID_RS00280	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AFERRID_RS00285	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AFERRID_RS00300	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AFERRID_RS00310	COG2326	polyphosphate kinase activity
AFERRID_RS00325	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AFERRID_RS00335	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AFERRID_RS00345	COG3387	PFAM Glycoside hydrolase 15-related
AFERRID_RS00355	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFERRID_RS00360	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFERRID_RS00365	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFERRID_RS00365	COG0649	NAD binding
AFERRID_RS00375	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AFERRID_RS00385	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AFERRID_RS00390	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFERRID_RS00400	COG0713	ATP synthesis coupled electron transport
AFERRID_RS00415	COG1007	ATP synthesis coupled electron transport
AFERRID_RS00420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AFERRID_RS00435	COG1028	Short-chain dehydrogenase reductase Sdr
AFERRID_RS00450	COG0583	DNA-binding transcription factor activity
AFERRID_RS00470	COG2814	Major facilitator Superfamily
AFERRID_RS00540	COG0076	glutamate decarboxylase activity
AFERRID_RS00565	COG2995	paraquat-inducible protein a
AFERRID_RS00590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AFERRID_RS00595	COG2217	Heavy metal translocating P-type atpase
AFERRID_RS00640	COG4974	Belongs to the 'phage' integrase family
AFERRID_RS00675	COG3561	AntA/AntB antirepressor
AFERRID_RS00775	COG2932	Transcriptional regulator
AFERRID_RS00790	COG4115	mRNA cleavage
AFERRID_RS00795	COG2161	toxin-antitoxin pair type II binding
AFERRID_RS00815	COG0642	Histidine kinase
AFERRID_RS00920	COG4968	Prepilin-type N-terminal cleavage methylation domain
AFERRID_RS01000	COG3093	addiction module antidote protein HigA
AFERRID_RS01015	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AFERRID_RS01020	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AFERRID_RS01025	COG1862	Preprotein translocase
AFERRID_RS01030	COG0343	queuine tRNA-ribosyltransferase activity
AFERRID_RS01035	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AFERRID_RS01040	COG1253	flavin adenine dinucleotide binding
AFERRID_RS01065	COG0285	dihydrofolate synthase activity
AFERRID_RS01070	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AFERRID_RS01075	COG0159	tryptophan synthase activity
AFERRID_RS01080	COG0133	tryptophan synthase activity
AFERRID_RS01090	COG0101	tRNA pseudouridine synthase activity
AFERRID_RS01100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AFERRID_RS01110	COG0746	molybdenum cofactor guanylyltransferase activity
AFERRID_RS01115	COG1763	Mo-molybdopterin cofactor biosynthetic process
AFERRID_RS01120	COG0303	'Molybdopterin
AFERRID_RS01125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AFERRID_RS01130	COG0616	signal peptide processing
AFERRID_RS01210	COG2226	methyltransferase
AFERRID_RS01225	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFERRID_RS01230	COG0154	amidase activity
AFERRID_RS01235	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFERRID_RS01270	COG3394	polysaccharide catabolic process
AFERRID_RS01285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFERRID_RS01290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AFERRID_RS01295	COG1657	PFAM Prenyltransferase squalene oxidase
AFERRID_RS01300	COG1562	ergosterol biosynthetic process
AFERRID_RS01305	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AFERRID_RS01310	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AFERRID_RS01325	COG0442	prolyl-tRNA aminoacylation
AFERRID_RS01345	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AFERRID_RS01360	COG1692	metallophosphoesterase
AFERRID_RS01365	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AFERRID_RS01385	COG0768	penicillin binding
AFERRID_RS01390	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AFERRID_RS01395	COG0193	aminoacyl-tRNA hydrolase activity
AFERRID_RS01400	COG0012	GTP binding
AFERRID_RS01405	COG1396	sequence-specific DNA binding
AFERRID_RS01425	COG0650	Formate hydrogenlyase subunit 4
AFERRID_RS01435	COG0651	ATP synthesis coupled electron transport
AFERRID_RS01440	COG3261	NADH dehydrogenase
AFERRID_RS01440	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
AFERRID_RS01445	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFERRID_RS01450	COG1850	ribulose-bisphosphate carboxylase activity
AFERRID_RS01470	COG2824	Alkylphosphonate utilization operon protein PhnA
AFERRID_RS01480	COG0726	polysaccharide deacetylase
AFERRID_RS01480	COG1649	PFAM Uncharacterised BCR, COG1649
AFERRID_RS01490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AFERRID_RS01495	COG0494	nUDIX hydrolase
AFERRID_RS01505	COG1187	pseudouridine synthase activity
AFERRID_RS01510	COG2957	Belongs to the agmatine deiminase family
AFERRID_RS01515	COG0243	molybdopterin cofactor binding
AFERRID_RS01545	COG0210	DNA helicase
AFERRID_RS01550	COG0268	Binds directly to 16S ribosomal RNA
AFERRID_RS01555	COG3842	ATPase activity
AFERRID_RS01570	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AFERRID_RS01575	COG0514	ATP-dependent DNA helicase (RecQ)
AFERRID_RS01580	COG1965	Belongs to the frataxin family
AFERRID_RS01600	COG0795	lipopolysaccharide-transporting ATPase activity
AFERRID_RS01605	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AFERRID_RS01620	COG0525	valine-tRNA ligase activity
AFERRID_RS01625	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AFERRID_RS01645	COG0412	Dienelactone hydrolase
AFERRID_RS01650	COG1902	pentaerythritol trinitrate reductase activity
AFERRID_RS01665	COG3152	Membrane
AFERRID_RS01685	COG0546	phosphoglycolate phosphatase activity
AFERRID_RS01695	COG1530	ribonuclease E activity
AFERRID_RS01700	COG0215	cysteine-tRNA ligase activity
AFERRID_RS01705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFERRID_RS01725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFERRID_RS01730	COG0745	RESPONSE REGULATOR receiver
AFERRID_RS01745	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AFERRID_RS01755	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AFERRID_RS01760	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AFERRID_RS01770	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AFERRID_RS01840	COG0138	bifunctional purine biosynthesis protein purh
AFERRID_RS01845	COG0151	Belongs to the GarS family
AFERRID_RS01850	COG0009	L-threonylcarbamoyladenylate synthase
AFERRID_RS01855	COG0408	coproporphyrinogen oxidase activity
AFERRID_RS01860	COG0167	dihydroorotate dehydrogenase activity
AFERRID_RS01885	COG0811	peptide transport
AFERRID_RS01925	COG2814	Major facilitator Superfamily
AFERRID_RS01930	COG2062	phosphohistidine phosphatase, SixA
AFERRID_RS01955	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AFERRID_RS01960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFERRID_RS01975	COG0033	Phosphoglucomutase
AFERRID_RS01990	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AFERRID_RS02000	COG3038	cytochrome b561
AFERRID_RS02010	COG2814	Major facilitator Superfamily
AFERRID_RS02015	COG0583	DNA-binding transcription factor activity
AFERRID_RS02035	COG1193	negative regulation of DNA recombination
AFERRID_RS02045	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AFERRID_RS02060	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AFERRID_RS02065	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AFERRID_RS02080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AFERRID_RS02100	COG1686	Belongs to the peptidase S11 family
AFERRID_RS02135	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AFERRID_RS02140	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AFERRID_RS02150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AFERRID_RS02160	COG1272	protein, Hemolysin III
AFERRID_RS02165	COG0860	N-Acetylmuramoyl-L-alanine amidase
AFERRID_RS02175	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AFERRID_RS02180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFERRID_RS02195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFERRID_RS02205	COG0640	Transcriptional regulator
AFERRID_RS02215	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AFERRID_RS02230	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AFERRID_RS02235	COG0084	hydrolase, TatD family'
AFERRID_RS02240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFERRID_RS02245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFERRID_RS02275	COG2827	Endonuclease containing a URI domain
AFERRID_RS02310	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AFERRID_RS02405	COG1199	ATP-dependent helicase activity
AFERRID_RS02420	COG0791	NLP P60 protein
AFERRID_RS02450	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AFERRID_RS02455	COG0586	Pfam SNARE associated Golgi protein
AFERRID_RS02470	COG0583	DNA-binding transcription factor activity
AFERRID_RS02485	COG0123	including yeast histone deacetylase and acetoin utilization protein
AFERRID_RS02535	COG0644	oxidoreductase
AFERRID_RS02540	COG0095	Lipoate-protein ligase
AFERRID_RS02550	COG0509	glycine decarboxylation via glycine cleavage system
AFERRID_RS02560	COG0509	glycine decarboxylation via glycine cleavage system
AFERRID_RS02565	COG2048	Heterodisulfide reductase, subunit B
AFERRID_RS02595	COG2210	Belongs to the sulfur carrier protein TusA family
AFERRID_RS02600	COG0425	Belongs to the sulfur carrier protein TusA family
AFERRID_RS02605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFERRID_RS02610	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AFERRID_RS02620	COG0315	cyclic pyranopterin monophosphate synthase activity
AFERRID_RS02630	COG1792	Involved in formation and maintenance of cell shape
AFERRID_RS02640	COG0768	penicillin binding
AFERRID_RS02645	COG0772	Belongs to the SEDS family
AFERRID_RS02650	COG1686	Belongs to the peptidase S11 family
AFERRID_RS02660	COG0321	lipoyl(octanoyl) transferase activity
AFERRID_RS02665	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AFERRID_RS02715	COG0751	glycine-tRNA ligase activity
AFERRID_RS02720	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AFERRID_RS02730	COG0189	ligase activity
AFERRID_RS02750	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AFERRID_RS02780	COG0625	glutathione transferase activity
AFERRID_RS02785	COG1733	regulation of RNA biosynthetic process
AFERRID_RS02790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFERRID_RS02840	COG0776	regulation of translation
AFERRID_RS02845	COG0072	phenylalanine-tRNA ligase activity
AFERRID_RS02845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFERRID_RS02850	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AFERRID_RS02855	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AFERRID_RS02860	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AFERRID_RS02865	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AFERRID_RS02870	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AFERRID_RS02880	COG1007	ATP synthesis coupled electron transport
AFERRID_RS02895	COG0713	ATP synthesis coupled electron transport
AFERRID_RS02905	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFERRID_RS02910	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AFERRID_RS02915	COG1034	ATP synthesis coupled electron transport
AFERRID_RS02925	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AFERRID_RS02930	COG0649	NAD binding
AFERRID_RS02935	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFERRID_RS02940	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFERRID_RS02945	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFERRID_RS02955	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AFERRID_RS02965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFERRID_RS02970	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AFERRID_RS02975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFERRID_RS02980	COG0312	modulator of DNA gyrase
AFERRID_RS02985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFERRID_RS02985	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AFERRID_RS02990	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFERRID_RS03110	COG0717	Belongs to the dCTP deaminase family
AFERRID_RS03115	COG0489	protein tyrosine kinase activity
AFERRID_RS03125	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AFERRID_RS03130	COG0484	heat shock protein binding
AFERRID_RS03135	COG0443	Heat shock 70 kDa protein
AFERRID_RS03140	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AFERRID_RS03150	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AFERRID_RS03155	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AFERRID_RS03160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFERRID_RS03160	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFERRID_RS03165	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AFERRID_RS03170	COG0114	fumarate hydratase activity
AFERRID_RS03195	COG0297	glycogen (starch) synthase activity
AFERRID_RS03200	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AFERRID_RS03210	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AFERRID_RS03240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFERRID_RS03295	COG4964	Belongs to the GSP D family
AFERRID_RS03350	COG0457	Tetratricopeptide repeat
AFERRID_RS03380	COG0826	peptidase U32
AFERRID_RS03385	COG0826	peptidase U32
AFERRID_RS03410	COG1028	Short-chain dehydrogenase reductase Sdr
AFERRID_RS03415	COG0723	plastoquinol--plastocyanin reductase activity
AFERRID_RS03420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AFERRID_RS03425	COG2857	Cytochrome c1
AFERRID_RS03450	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AFERRID_RS03455	COG1534	Rna-binding protein
AFERRID_RS03460	COG2967	ApaG domain
AFERRID_RS03465	COG2226	methyltransferase
AFERRID_RS03485	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AFERRID_RS03495	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AFERRID_RS03505	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AFERRID_RS03520	COG2177	Part of the ABC transporter FtsEX involved in
AFERRID_RS03525	COG2884	Cell division ATP-binding protein ftsE
AFERRID_RS03530	COG0552	protein localization to endoplasmic reticulum
AFERRID_RS03535	COG0742	ribosomal rna small subunit methyltransferase
AFERRID_RS03540	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AFERRID_RS03545	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AFERRID_RS03550	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AFERRID_RS03555	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AFERRID_RS03560	COG2890	protein-(glutamine-N5) methyltransferase activity
AFERRID_RS03565	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AFERRID_RS03570	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AFERRID_RS03580	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AFERRID_RS03585	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AFERRID_RS03595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AFERRID_RS03620	COG2860	membrane
AFERRID_RS03665	COG2943	transferase activity, transferring hexosyl groups
AFERRID_RS03670	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AFERRID_RS03735	COG0746	molybdenum cofactor guanylyltransferase activity
AFERRID_RS03770	COG1872	DUF167
AFERRID_RS03795	COG0148	phosphopyruvate hydratase activity
AFERRID_RS03805	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AFERRID_RS03825	COG3459	Glycosyltransferase 36 associated
AFERRID_RS03860	COG0006	proline dipeptidase activity
AFERRID_RS03875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AFERRID_RS03880	COG0305	Participates in initiation and elongation during chromosome replication
AFERRID_RS03885	COG0359	binds to the 23S rRNA
AFERRID_RS03900	COG0360	Binds together with S18 to 16S ribosomal RNA
AFERRID_RS03905	COG1472	Belongs to the glycosyl hydrolase 3 family
AFERRID_RS03910	COG0531	amino acid
AFERRID_RS03920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AFERRID_RS03945	COG0363	glucosamine-6-phosphate deaminase activity
AFERRID_RS03960	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AFERRID_RS03965	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AFERRID_RS03975	COG1449	Belongs to the glycosyl hydrolase 57 family
AFERRID_RS03980	COG1940	carbohydrate kinase activity
AFERRID_RS03985	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AFERRID_RS03990	COG2733	membrane
AFERRID_RS04000	COG0629	single-stranded DNA binding
AFERRID_RS04015	COG3118	belongs to the thioredoxin family
AFERRID_RS04020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFERRID_RS04035	COG0335	large ribosomal subunit rRNA binding
AFERRID_RS04040	COG0336	Belongs to the RNA methyltransferase TrmD family
AFERRID_RS04045	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AFERRID_RS04050	COG0228	four-way junction DNA binding
AFERRID_RS04055	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AFERRID_RS04075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AFERRID_RS04085	COG1131	(ABC) transporter
AFERRID_RS04090	COG0842	Transport permease protein
AFERRID_RS04120	COG0509	glycine decarboxylation via glycine cleavage system
AFERRID_RS04150	COG2885	chlorophyll binding
AFERRID_RS04220	COG1573	uracil-dna glycosylase
AFERRID_RS04230	COG0488	(ABC) transporter
AFERRID_RS04265	COG0142	geranyltranstransferase activity
AFERRID_RS04290	COG2308	Evidence 4 Homologs of previously reported genes of
AFERRID_RS04305	COG2766	serine protein kinase
AFERRID_RS04310	COG0004	ammonium transporteR
AFERRID_RS04315	COG2718	Belongs to the UPF0229 family
AFERRID_RS04330	COG0347	Belongs to the P(II) protein family
AFERRID_RS04335	COG0004	ammonium transporteR
AFERRID_RS04365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AFERRID_RS04370	COG1686	Belongs to the peptidase S11 family
AFERRID_RS04375	COG0166	Belongs to the GPI family
AFERRID_RS04390	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AFERRID_RS04405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AFERRID_RS04420	COG1074	ATP-dependent DNA helicase activity
AFERRID_RS04455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AFERRID_RS04465	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AFERRID_RS04475	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AFERRID_RS04485	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AFERRID_RS04500	COG0424	maF-like protein
AFERRID_RS04505	COG1530	ribonuclease E activity
AFERRID_RS04510	COG2204	response regulator
AFERRID_RS04520	COG2205	protein histidine kinase activity
AFERRID_RS04530	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AFERRID_RS04540	COG1596	polysaccharide export
AFERRID_RS04585	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AFERRID_RS04650	COG1132	(ABC) transporter
AFERRID_RS04680	COG0444	Belongs to the ABC transporter superfamily
AFERRID_RS04685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFERRID_RS04690	COG0601	transmembrane transport
AFERRID_RS04715	COG2095	MarC family integral membrane protein
AFERRID_RS04720	COG0039	L-malate dehydrogenase activity
AFERRID_RS04735	COG0811	peptide transport
AFERRID_RS04740	COG0848	biopolymer transport protein
AFERRID_RS04760	COG3321	synthase
AFERRID_RS04760	COG1028	Short-chain dehydrogenase reductase Sdr
AFERRID_RS04760	COG0604	alcohol dehydrogenase
AFERRID_RS04765	COG0156	8-amino-7-oxononanoate synthase activity
AFERRID_RS04790	COG1194	a g-specific adenine glycosylase
AFERRID_RS04800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFERRID_RS04805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFERRID_RS04815	COG1660	Displays ATPase and GTPase activities
AFERRID_RS04820	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AFERRID_RS04825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AFERRID_RS04825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFERRID_RS04825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AFERRID_RS04845	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AFERRID_RS04855	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AFERRID_RS04880	COG3178	'Phosphotransferase
AFERRID_RS04885	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AFERRID_RS04890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AFERRID_RS04900	COG0271	Belongs to the BolA IbaG family
AFERRID_RS04905	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AFERRID_RS04910	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AFERRID_RS04915	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AFERRID_RS04925	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFERRID_RS04930	COG0131	Imidazoleglycerol-phosphate dehydratase
AFERRID_RS04935	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AFERRID_RS04940	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AFERRID_RS04945	COG0107	imidazoleglycerol-phosphate synthase activity
AFERRID_RS04950	COG0140	phosphoribosyl-ATP diphosphatase activity
AFERRID_RS04950	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AFERRID_RS04955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFERRID_RS04960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFERRID_RS04965	COG0805	protein transport
AFERRID_RS04970	COG1850	ribulose-bisphosphate carboxylase activity
AFERRID_RS04990	COG0776	regulation of translation
AFERRID_RS05005	COG0540	Belongs to the ATCase OTCase family
AFERRID_RS05010	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AFERRID_RS05020	COG1678	Uncharacterized ACR, COG1678
AFERRID_RS05025	COG0189	ligase activity
AFERRID_RS05040	COG0316	Belongs to the HesB IscA family
AFERRID_RS05045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFERRID_RS05050	COG0022	dehydrogenase e1 component
AFERRID_RS05050	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFERRID_RS05055	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AFERRID_RS05070	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AFERRID_RS05075	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AFERRID_RS05080	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AFERRID_RS05090	COG0778	Nitroreductase
AFERRID_RS05125	COG1376	ErfK ybiS ycfS ynhG family protein
AFERRID_RS05135	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AFERRID_RS05150	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AFERRID_RS05160	COG0492	ferredoxin-NADP+ reductase activity
AFERRID_RS05170	COG0789	Transcriptional regulator
AFERRID_RS05175	COG0585	pseudouridine synthase activity
AFERRID_RS05180	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AFERRID_RS05185	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AFERRID_RS05190	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AFERRID_RS05195	COG0560	Phosphoserine phosphatase
AFERRID_RS05200	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AFERRID_RS05200	COG0678	peroxiredoxin activity
AFERRID_RS05215	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AFERRID_RS05235	COG0671	phosphoesterase, PA-phosphatase related
AFERRID_RS05245	COG2003	Belongs to the UPF0758 family
AFERRID_RS05250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AFERRID_RS05255	COG0756	dUTP diphosphatase activity
AFERRID_RS05260	COG0203	ribosomal protein L17
AFERRID_RS05265	COG0202	RNA polymerase activity
AFERRID_RS05270	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AFERRID_RS05275	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AFERRID_RS05280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AFERRID_RS05285	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AFERRID_RS05290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AFERRID_RS05295	COG0563	adenylate kinase activity
AFERRID_RS05300	COG0201	protein transport
AFERRID_RS05305	COG0200	Binds to the 23S rRNA
AFERRID_RS05310	COG1841	ribosomal large subunit assembly
AFERRID_RS05315	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AFERRID_RS05320	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AFERRID_RS05325	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AFERRID_RS05330	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AFERRID_RS05335	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AFERRID_RS05340	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AFERRID_RS05345	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AFERRID_RS05350	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AFERRID_RS05355	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AFERRID_RS05360	COG0255	Belongs to the universal ribosomal protein uL29 family
AFERRID_RS05365	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AFERRID_RS05375	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AFERRID_RS05380	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AFERRID_RS05385	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AFERRID_RS05390	COG0089	rRNA binding
AFERRID_RS05395	COG0088	Forms part of the polypeptide exit tunnel
AFERRID_RS05400	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AFERRID_RS05405	COG0051	transcription antitermination factor activity, RNA binding
AFERRID_RS05410	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AFERRID_RS05415	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AFERRID_RS05420	COG0049	tRNA binding
AFERRID_RS05425	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AFERRID_RS05430	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AFERRID_RS05435	COG0085	RNA polymerase activity
AFERRID_RS05440	COG0222	ribosome binding
AFERRID_RS05445	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AFERRID_RS05450	COG0081	regulation of translation
AFERRID_RS05455	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AFERRID_RS05475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AFERRID_RS05500	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AFERRID_RS05520	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AFERRID_RS05525	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AFERRID_RS05540	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFERRID_RS05540	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFERRID_RS05545	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AFERRID_RS05560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AFERRID_RS05565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AFERRID_RS05565	COG2813	Specifically methylates the guanine in position
AFERRID_RS05575	COG2226	methyltransferase
AFERRID_RS05580	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AFERRID_RS05585	COG0288	reversible hydration of carbon dioxide
AFERRID_RS05590	COG0659	secondary active sulfate transmembrane transporter activity
AFERRID_RS05625	COG1671	Belongs to the UPF0178 family
AFERRID_RS05630	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AFERRID_RS05635	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AFERRID_RS05640	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AFERRID_RS05645	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AFERRID_RS05650	COG0735	belongs to the Fur family
AFERRID_RS05670	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AFERRID_RS05690	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AFERRID_RS05695	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AFERRID_RS05700	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AFERRID_RS05705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AFERRID_RS05760	COG1872	DUF167
AFERRID_RS05765	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AFERRID_RS05775	COG1566	PFAM secretion protein HlyD family protein
AFERRID_RS05780	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AFERRID_RS05785	COG1309	transcriptional regulator
AFERRID_RS05805	COG0543	2 iron, 2 sulfur cluster binding
AFERRID_RS05805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFERRID_RS05815	COG0390	transport system, permease component
AFERRID_RS05820	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AFERRID_RS05825	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AFERRID_RS05835	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AFERRID_RS05850	COG0156	8-amino-7-oxononanoate synthase activity
AFERRID_RS05855	COG1040	competence protein
AFERRID_RS05865	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AFERRID_RS05870	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AFERRID_RS05875	COG1560	Kdo2-lipid A biosynthetic process
AFERRID_RS05880	COG1519	Transferase
AFERRID_RS05890	COG0859	PFAM glycosyl transferase family 9
AFERRID_RS05895	COG0463	Glycosyl transferase, family 2
AFERRID_RS05915	COG0297	glycogen (starch) synthase activity
AFERRID_RS05925	COG0463	Glycosyl transferase, family 2
AFERRID_RS05930	COG0494	nUDIX hydrolase
AFERRID_RS05935	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AFERRID_RS05940	COG0653	protein targeting
AFERRID_RS05950	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AFERRID_RS05955	COG0625	glutathione transferase activity
AFERRID_RS05960	COG1022	Amp-dependent synthetase and ligase
AFERRID_RS05965	COG0617	tRNA 3'-terminal CCA addition
AFERRID_RS05980	COG2001	Belongs to the MraZ family
AFERRID_RS05985	COG0275	rRNA processing
AFERRID_RS06000	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AFERRID_RS06005	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AFERRID_RS06010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AFERRID_RS06015	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AFERRID_RS06020	COG0772	Belongs to the SEDS family
AFERRID_RS06025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AFERRID_RS06030	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AFERRID_RS06035	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AFERRID_RS06040	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFERRID_RS06055	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AFERRID_RS06070	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AFERRID_RS06075	COG0511	ligase activity, forming carbon-carbon bonds
AFERRID_RS06080	COG0439	Biotin carboxylase
AFERRID_RS06085	COG2264	protein methyltransferase activity
AFERRID_RS06095	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AFERRID_RS06100	COG1196	nuclear chromosome segregation
AFERRID_RS06100	COG0741	lytic transglycosylase activity
AFERRID_RS06100	COG0739	heme binding
AFERRID_RS06110	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AFERRID_RS06120	COG0237	dephospho-CoA kinase activity
AFERRID_RS06140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AFERRID_RS06145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AFERRID_RS06150	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AFERRID_RS06155	COG1047	Peptidyl-prolyl cis-trans
AFERRID_RS06160	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AFERRID_RS06170	COG0625	glutathione transferase activity
AFERRID_RS06175	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AFERRID_RS06185	COG0708	Exodeoxyribonuclease III
AFERRID_RS06195	COG0583	DNA-binding transcription factor activity
AFERRID_RS06205	COG0018	arginyl-trna synthetase
AFERRID_RS06220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AFERRID_RS06230	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AFERRID_RS06235	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AFERRID_RS06240	COG1131	(ABC) transporter
AFERRID_RS06255	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AFERRID_RS06260	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AFERRID_RS06270	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AFERRID_RS06275	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AFERRID_RS06285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AFERRID_RS06295	COG2363	Small membrane protein
AFERRID_RS06305	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AFERRID_RS06320	COG1902	pentaerythritol trinitrate reductase activity
AFERRID_RS06325	COG3077	Addiction module antitoxin, RelB DinJ family
AFERRID_RS06345	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AFERRID_RS06385	COG0535	radical SAM domain protein
AFERRID_RS06400	COG0582	viral genome integration into host DNA
AFERRID_RS06415	COG3107	peptidoglycan biosynthetic process
AFERRID_RS06425	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AFERRID_RS06430	COG0277	FAD linked oxidase domain protein
AFERRID_RS06450	COG0583	DNA-binding transcription factor activity
AFERRID_RS06490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFERRID_RS06495	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AFERRID_RS06500	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AFERRID_RS06510	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AFERRID_RS06515	COG2833	Protein of unknown function (DUF455)
AFERRID_RS06550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFERRID_RS06580	COG1136	(ABC) transporter
AFERRID_RS06630	COG4453	Protein conserved in bacteria
AFERRID_RS06655	COG0789	Transcriptional regulator
AFERRID_RS06735	COG4115	mRNA cleavage
AFERRID_RS06740	COG2161	toxin-antitoxin pair type II binding
AFERRID_RS06745	COG4691	Plasmid stability protein
AFERRID_RS06765	COG0602	queuosine metabolic process
AFERRID_RS06770	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AFERRID_RS06795	COG0824	Thioesterase
AFERRID_RS06800	COG2255	four-way junction helicase activity
AFERRID_RS06805	COG0632	four-way junction helicase activity
AFERRID_RS06810	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AFERRID_RS06815	COG0217	transcriptional regulatory protein
AFERRID_RS06825	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AFERRID_RS06830	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AFERRID_RS06840	COG2095	MarC family integral membrane protein
AFERRID_RS06920	COG1566	PFAM secretion protein HlyD family protein
AFERRID_RS06930	COG0488	(ABC) transporter
AFERRID_RS06935	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AFERRID_RS06945	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AFERRID_RS06950	COG0706	membrane insertase activity
AFERRID_RS06955	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AFERRID_RS06965	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AFERRID_RS06970	COG2204	response regulator
AFERRID_RS06985	COG1028	Short-chain dehydrogenase reductase Sdr
AFERRID_RS06990	COG0723	plastoquinol--plastocyanin reductase activity
AFERRID_RS06995	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AFERRID_RS07005	COG1333	cytochrome c biogenesis protein
AFERRID_RS07010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AFERRID_RS07055	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AFERRID_RS07060	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFERRID_RS07065	COG0175	sulfate reduction
AFERRID_RS07075	COG2895	sulfate adenylyltransferase (ATP) activity
AFERRID_RS07100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFERRID_RS07130	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AFERRID_RS07150	COG2814	Major facilitator Superfamily
AFERRID_RS07155	COG0109	protoheme IX farnesyltransferase activity
AFERRID_RS07180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AFERRID_RS07185	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AFERRID_RS07210	COG2204	response regulator
AFERRID_RS07215	COG5000	phosphorelay sensor kinase activity
AFERRID_RS07225	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AFERRID_RS07230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AFERRID_RS07235	COG0242	peptide deformylase activity
AFERRID_RS07245	COG0758	DNA mediated transformation
AFERRID_RS07250	COG2922	Belongs to the Smg family
AFERRID_RS07260	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AFERRID_RS07265	COG0850	regulation of cytokinetic process
AFERRID_RS07270	COG2894	cell division
AFERRID_RS07275	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AFERRID_RS07285	COG3267	Type II secretory pathway component ExeA
AFERRID_RS07285	COG3409	Peptidoglycan-binding domain 1 protein
AFERRID_RS07345	COG2165	general secretion pathway protein
AFERRID_RS07355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AFERRID_RS07360	COG0543	2 iron, 2 sulfur cluster binding
AFERRID_RS07360	COG0493	'glutamate synthase
AFERRID_RS07370	COG0187	DNA topoisomerase II activity
AFERRID_RS07380	COG0592	DNA-directed DNA polymerase activity
AFERRID_RS07385	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AFERRID_RS07390	COG0300	oxidoreductase activity
AFERRID_RS07395	COG0351	phosphomethylpyrimidine kinase
AFERRID_RS07400	COG0352	thiamine-phosphate diphosphorylase activity
AFERRID_RS07405	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AFERRID_RS07410	COG0537	adenosine 5'-monophosphoramidase activity
AFERRID_RS07420	COG0181	hydroxymethylbilane synthase activity
AFERRID_RS07430	COG0113	porphobilinogen synthase activity
AFERRID_RS07455	COG0662	Cupin 2, conserved barrel domain protein
AFERRID_RS07455	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AFERRID_RS07470	COG0409	Hydrogenase expression formation protein
AFERRID_RS07485	COG0375	protein maturation
AFERRID_RS07490	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AFERRID_RS07495	COG0247	lactate metabolic process
AFERRID_RS07495	COG2181	nitrate reductase activity
AFERRID_RS07535	COG0165	Argininosuccinate lyase
AFERRID_RS07605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFERRID_RS07620	COG1970	mechanosensitive ion channel activity
AFERRID_RS07625	COG1322	Protein conserved in bacteria
AFERRID_RS07630	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AFERRID_RS07635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AFERRID_RS07645	COG0483	inositol monophosphate 1-phosphatase activity
AFERRID_RS07650	COG1494	fructose-1,6-bisphosphatase
AFERRID_RS07655	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AFERRID_RS07660	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AFERRID_RS07680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AFERRID_RS07685	COG0546	phosphoglycolate phosphatase activity
AFERRID_RS07700	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AFERRID_RS07705	COG0134	indole-3-glycerol-phosphate synthase activity
AFERRID_RS07715	COG1959	2 iron, 2 sulfur cluster binding
AFERRID_RS07720	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AFERRID_RS07735	COG1131	(ABC) transporter
AFERRID_RS07750	COG0393	Putative heavy-metal-binding
AFERRID_RS07765	COG0625	glutathione transferase activity
AFERRID_RS07790	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AFERRID_RS07800	COG0732	type I restriction modification DNA specificity domain
AFERRID_RS07830	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AFERRID_RS07870	COG0655	NAD(P)H dehydrogenase (quinone) activity
AFERRID_RS07900	COG0521	Mo-molybdopterin cofactor biosynthetic process
AFERRID_RS07915	COG0445	tRNA wobble uridine modification
AFERRID_RS07920	COG0357	Ribosomal RNA small subunit methyltransferase G
AFERRID_RS07930	COG1475	DNA binding
AFERRID_RS07940	COG0356	it plays a direct role in the translocation of protons across the membrane
AFERRID_RS07950	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AFERRID_RS07955	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AFERRID_RS07960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AFERRID_RS07965	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AFERRID_RS07980	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AFERRID_RS07995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AFERRID_RS08000	COG0326	Molecular chaperone. Has ATPase activity
AFERRID_RS08005	COG1796	DNA polymerase
AFERRID_RS08005	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AFERRID_RS08025	COG0210	DNA helicase
AFERRID_RS08030	COG1555	photosystem II stabilization
AFERRID_RS08045	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AFERRID_RS08055	COG1611	Belongs to the LOG family
AFERRID_RS08065	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AFERRID_RS08070	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AFERRID_RS08080	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AFERRID_RS08085	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AFERRID_RS08120	COG0779	Required for maturation of 30S ribosomal subunits
AFERRID_RS08125	COG0195	Participates in both transcription termination and antitermination
AFERRID_RS08130	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AFERRID_RS08135	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AFERRID_RS08140	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AFERRID_RS08145	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AFERRID_RS08150	COG1185	polyribonucleotide nucleotidyltransferase activity
AFERRID_RS08155	COG0612	Peptidase, M16
AFERRID_RS08160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFERRID_RS08170	COG0328	RNA-DNA hybrid ribonuclease activity
AFERRID_RS08175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AFERRID_RS08195	COG0137	argininosuccinate synthase activity
AFERRID_RS08200	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AFERRID_RS08205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AFERRID_RS08210	COG0527	aspartate kinase activity
AFERRID_RS08240	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AFERRID_RS08250	COG0741	lytic transglycosylase activity
AFERRID_RS08250	COG1388	LysM domain
AFERRID_RS08255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFERRID_RS08280	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AFERRID_RS08285	COG0538	isocitrate dehydrogenase activity
AFERRID_RS08290	COG0045	succinate-CoA ligase (ADP-forming) activity
AFERRID_RS08300	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AFERRID_RS08305	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AFERRID_RS08305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFERRID_RS08335	COG1850	ribulose-bisphosphate carboxylase activity
AFERRID_RS08340	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
AFERRID_RS08345	COG0235	Class ii aldolase
AFERRID_RS08355	COG0242	peptide deformylase activity
AFERRID_RS08385	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AFERRID_RS08395	COG2204	response regulator
AFERRID_RS08405	COG2205	protein histidine kinase activity
AFERRID_RS08410	COG0497	DNA recombination
AFERRID_RS08415	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AFERRID_RS08420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AFERRID_RS08425	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AFERRID_RS08425	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AFERRID_RS08430	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AFERRID_RS08440	COG1466	dna polymerase III delta subunit
AFERRID_RS08450	COG0495	leucyl-tRNA aminoacylation
AFERRID_RS08455	COG0655	NAD(P)H dehydrogenase (quinone) activity
AFERRID_RS08460	COG2353	YceI-like domain
AFERRID_RS08465	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AFERRID_RS08470	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AFERRID_RS08495	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AFERRID_RS08515	COG0436	Aminotransferase
AFERRID_RS08525	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AFERRID_RS08535	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AFERRID_RS08545	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AFERRID_RS08555	COG1136	(ABC) transporter
AFERRID_RS08565	COG0658	competence protein
AFERRID_RS08565	COG2333	competence protein COMEC
AFERRID_RS08570	COG0811	peptide transport
AFERRID_RS08575	COG0848	biopolymer transport protein
AFERRID_RS08590	COG1663	tetraacyldisaccharide 4'-kinase activity
AFERRID_RS08595	COG2835	tetraacyldisaccharide 4'-kinase activity
AFERRID_RS08600	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AFERRID_RS08640	COG1942	4-Oxalocrotonate Tautomerase
AFERRID_RS08650	COG4372	Transposase
AFERRID_RS08715	COG1573	uracil-dna glycosylase
AFERRID_RS08725	COG0542	response to heat
AFERRID_RS08730	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AFERRID_RS08735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AFERRID_RS08740	COG0693	protein deglycase activity
AFERRID_RS08745	COG0793	Belongs to the peptidase S41A family
AFERRID_RS08755	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AFERRID_RS08760	COG0058	SHG alpha-glucan phosphorylase activity
AFERRID_RS08770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFERRID_RS08775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFERRID_RS08785	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AFERRID_RS08790	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AFERRID_RS08815	COG2046	Belongs to the sulfate adenylyltransferase family
AFERRID_RS08815	COG0529	Catalyzes the synthesis of activated sulfate
AFERRID_RS08825	COG0459	protein refolding
AFERRID_RS08830	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AFERRID_RS08855	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AFERRID_RS08865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFERRID_RS08885	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AFERRID_RS08890	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AFERRID_RS08895	COG0196	riboflavin kinase activity
AFERRID_RS08915	COG1561	YicC-like family, N-terminal region
AFERRID_RS08920	COG0194	GDP metabolic process
AFERRID_RS08925	COG1758	RNA polymerase activity
AFERRID_RS08930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFERRID_RS08960	COG0628	permease
AFERRID_RS08970	COG2078	PFAM AMMECR1 domain protein
AFERRID_RS08980	COG1538	Outer membrane efflux protein
AFERRID_RS09005	COG5377	YqaJ viral recombinase family
AFERRID_RS09040	COG4372	Transposase
AFERRID_RS09080	COG0513	Belongs to the DEAD box helicase family
AFERRID_RS09085	COG1278	Cold shock
AFERRID_RS09090	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AFERRID_RS09095	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AFERRID_RS09105	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AFERRID_RS09115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFERRID_RS09120	COG1702	phosphate starvation-inducible protein PhoH
AFERRID_RS09125	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AFERRID_RS09130	COG4535	Mg2 and Co2 transporter CorC
AFERRID_RS09135	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AFERRID_RS09140	COG0312	modulator of DNA gyrase
AFERRID_RS09150	COG1121	(ABC) transporter
AFERRID_RS09160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFERRID_RS09205	COG0438	transferase activity, transferring glycosyl groups
AFERRID_RS09215	COG1132	(ABC) transporter
AFERRID_RS09245	COG2226	methyltransferase
AFERRID_RS09250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AFERRID_RS09260	COG0066	3-isopropylmalate dehydratase activity
AFERRID_RS09270	COG0259	pyridoxamine-phosphate oxidase activity
AFERRID_RS09275	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AFERRID_RS09290	COG1271	oxidase subunit
AFERRID_RS09320	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AFERRID_RS09325	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AFERRID_RS09340	COG0109	protoheme IX farnesyltransferase activity
AFERRID_RS09345	COG2814	Major facilitator Superfamily
AFERRID_RS09350	COG1968	undecaprenyl-diphosphatase activity
AFERRID_RS09355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AFERRID_RS09365	COG0505	Belongs to the CarA family
AFERRID_RS09380	COG2022	thiamine diphosphate biosynthetic process
AFERRID_RS09390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AFERRID_RS09395	COG0163	prenyltransferase activity
AFERRID_RS09400	COG1127	ABC transporter
AFERRID_RS09405	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AFERRID_RS09425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AFERRID_RS09435	COG0577	efflux transmembrane transporter activity
AFERRID_RS09440	COG1136	(ABC) transporter
AFERRID_RS09460	COG0254	rRNA binding
AFERRID_RS09465	COG0281	malic enzyme
AFERRID_RS09470	COG0628	permease
AFERRID_RS09475	COG0129	dihydroxy-acid dehydratase activity
AFERRID_RS09485	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AFERRID_RS09485	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AFERRID_RS09490	COG0271	Belongs to the BolA IbaG family
AFERRID_RS09495	COG2350	Protein conserved in bacteria
AFERRID_RS09500	COG2917	probably involved in intracellular septation
AFERRID_RS09515	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AFERRID_RS09530	COG1104	cysteine desulfurase activity
AFERRID_RS09535	COG0822	iron-sulfur transferase activity
AFERRID_RS09550	COG0443	Heat shock 70 kDa protein
AFERRID_RS09565	COG0482	sulfurtransferase activity
AFERRID_RS09570	COG1752	Esterase of the alpha-beta hydrolase superfamily
AFERRID_RS09595	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AFERRID_RS09620	COG3791	Glutathione-dependent formaldehyde-activating
AFERRID_RS09625	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AFERRID_RS09630	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AFERRID_RS09635	COG0583	DNA-binding transcription factor activity
AFERRID_RS09640	COG2204	response regulator
AFERRID_RS09690	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AFERRID_RS09710	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AFERRID_RS09725	COG0375	protein maturation
AFERRID_RS09755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AFERRID_RS09785	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AFERRID_RS09790	COG0493	'glutamate synthase
AFERRID_RS09800	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AFERRID_RS09805	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AFERRID_RS09815	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AFERRID_RS09850	COG0432	Pfam Uncharacterised protein family UPF0047
AFERRID_RS09860	COG1193	negative regulation of DNA recombination
AFERRID_RS09865	COG0028	Belongs to the TPP enzyme family
AFERRID_RS09875	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AFERRID_RS09880	COG0688	phosphatidylethanolamine metabolic process
AFERRID_RS09885	COG1183	phosphatidylcholine synthase activity
AFERRID_RS09895	COG0589	response to stress
AFERRID_RS09900	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AFERRID_RS09905	COG1196	nuclear chromosome segregation
AFERRID_RS09920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AFERRID_RS09960	COG0730	response to heat
AFERRID_RS09965	COG0811	peptide transport
AFERRID_RS09985	COG0402	S-adenosylhomocysteine deaminase activity
AFERRID_RS09990	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AFERRID_RS10025	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AFERRID_RS10025	COG3608	succinylglutamate desuccinylase aspartoacylase
AFERRID_RS10045	COG0746	molybdenum cofactor guanylyltransferase activity
AFERRID_RS10105	COG0475	glutathione-regulated potassium exporter activity
AFERRID_RS10110	COG1028	Short-chain dehydrogenase reductase Sdr
AFERRID_RS10155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AFERRID_RS10195	COG2814	Major facilitator Superfamily
AFERRID_RS10200	COG0038	chloride channel
AFERRID_RS10215	COG2217	Heavy metal translocating P-type atpase
AFERRID_RS10215	COG2217	Heavy metal translocating P-type atpase
AFERRID_RS10235	COG4654	Cytochrome c, class I
AFERRID_RS10250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AFERRID_RS10255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AFERRID_RS10265	COG0583	DNA-binding transcription factor activity
AFERRID_RS10310	COG0477	Major facilitator Superfamily
AFERRID_RS10320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFERRID_RS10320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFERRID_RS10335	COG2154	pterin-4-alpha-carbinolamine dehydratase
AFERRID_RS10350	COG1064	alcohol dehydrogenase
AFERRID_RS10355	COG0504	CTP synthase activity
AFERRID_RS10360	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AFERRID_RS10365	COG0148	phosphopyruvate hydratase activity
AFERRID_RS10370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AFERRID_RS10375	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AFERRID_RS10385	COG0322	excinuclease ABC activity
AFERRID_RS10410	COG0745	RESPONSE REGULATOR receiver
AFERRID_RS10420	COG1648	precorrin-2 dehydrogenase activity
AFERRID_RS10420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AFERRID_RS10425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AFERRID_RS10430	COG0243	molybdopterin cofactor binding
AFERRID_RS10435	COG2146	nitrite reductase [NAD(P)H] activity
AFERRID_RS10440	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFERRID_RS10450	COG2223	nitrite transmembrane transporter activity
AFERRID_RS10455	COG1116	anion transmembrane transporter activity
AFERRID_RS10455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AFERRID_RS10465	COG3189	MarR family transcriptional regulator
AFERRID_RS10480	COG1017	nitric oxide dioxygenase activity
AFERRID_RS10480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFERRID_RS10485	COG1566	PFAM secretion protein HlyD family protein
AFERRID_RS10490	COG1538	Outer membrane efflux protein
AFERRID_RS10495	COG2814	Major facilitator Superfamily
AFERRID_RS10500	COG0583	DNA-binding transcription factor activity
AFERRID_RS10550	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AFERRID_RS10560	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AFERRID_RS10565	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AFERRID_RS10575	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFERRID_RS10585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFERRID_RS10590	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AFERRID_RS10595	COG0287	Prephenate dehydrogenase
AFERRID_RS10600	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AFERRID_RS10605	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AFERRID_RS10615	COG0776	regulation of translation
AFERRID_RS10620	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AFERRID_RS10625	COG0284	orotidine-5'-phosphate decarboxylase activity
AFERRID_RS10630	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AFERRID_RS10635	COG0544	peptidyl-prolyl cis-trans isomerase activity
AFERRID_RS10640	COG0740	serine-type endopeptidase activity
AFERRID_RS10645	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AFERRID_RS10650	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AFERRID_RS10670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AFERRID_RS10700	COG2915	High frequency lysogenization protein hflD homolog
AFERRID_RS10705	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AFERRID_RS10710	COG0024	Methionine aminopeptidase
AFERRID_RS10715	COG1489	DNA binding
AFERRID_RS10720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFERRID_RS10730	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AFERRID_RS10735	COG1546	Belongs to the CinA family
AFERRID_RS10735	COG1058	Belongs to the CinA family
AFERRID_RS10740	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AFERRID_RS10745	COG2137	regulation of response to DNA damage stimulus
AFERRID_RS10810	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AFERRID_RS10835	COG1294	oxidase, subunit
AFERRID_RS10840	COG1271	oxidase subunit
AFERRID_RS10855	COG0400	carboxylic ester hydrolase activity
AFERRID_RS10860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFERRID_RS10865	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AFERRID_RS10875	COG2943	transferase activity, transferring hexosyl groups
AFERRID_RS10875	COG3416	Protein conserved in bacteria
AFERRID_RS10885	COG2363	Small membrane protein
AFERRID_RS10895	COG0616	signal peptide processing
AFERRID_RS10900	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AFERRID_RS10905	COG0314	molybdopterin synthase activity
AFERRID_RS10910	COG1666	GTP binding
AFERRID_RS10920	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AFERRID_RS10925	COG0509	glycine decarboxylation via glycine cleavage system
AFERRID_RS10935	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFERRID_RS10940	COG1132	(ABC) transporter
AFERRID_RS10945	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AFERRID_RS10950	COG0450	alkyl hydroperoxide reductase
AFERRID_RS10960	COG0613	PHP domain protein
AFERRID_RS10965	COG0628	permease
AFERRID_RS10985	COG0084	hydrolase, TatD family'
AFERRID_RS10990	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AFERRID_RS10990	COG0321	lipoyl(octanoyl) transferase activity
AFERRID_RS11005	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AFERRID_RS11015	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AFERRID_RS11030	COG2353	YceI-like domain
AFERRID_RS11040	COG1846	Transcriptional regulator
AFERRID_RS11060	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AFERRID_RS11070	COG0354	folic acid binding
AFERRID_RS11080	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AFERRID_RS11100	COG0481	GTPase activity
AFERRID_RS11105	COG0681	Belongs to the peptidase S26 family
AFERRID_RS11115	COG0571	ribonuclease III activity
AFERRID_RS11120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AFERRID_RS11125	COG1381	Involved in DNA repair and RecF pathway recombination
AFERRID_RS11130	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AFERRID_RS11135	COG0736	holo-[acyl-carrier-protein] synthase activity
AFERRID_RS11145	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AFERRID_RS11145	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AFERRID_RS11150	COG0037	tRNA processing
AFERRID_RS11155	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AFERRID_RS11175	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AFERRID_RS11185	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AFERRID_RS11250	COG0513	Belongs to the DEAD box helicase family
AFERRID_RS11265	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AFERRID_RS11270	COG0573	inorganic phosphate transmembrane transporter activity
AFERRID_RS11275	COG0581	inorganic phosphate transmembrane transporter activity
AFERRID_RS11280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AFERRID_RS11285	COG0704	Plays a role in the regulation of phosphate uptake
AFERRID_RS11300	COG0052	Belongs to the universal ribosomal protein uS2 family
AFERRID_RS11305	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AFERRID_RS11310	COG0528	UMP kinase activity
AFERRID_RS11320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AFERRID_RS11325	COG0575	Belongs to the CDS family
AFERRID_RS11330	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AFERRID_RS11350	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AFERRID_RS11355	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AFERRID_RS11360	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AFERRID_RS11365	COG0673	inositol 2-dehydrogenase activity
AFERRID_RS11375	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AFERRID_RS11390	COG0825	malonyl-CoA metabolic process
AFERRID_RS11395	COG0037	tRNA processing
AFERRID_RS11405	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AFERRID_RS11410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFERRID_RS11420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AFERRID_RS11425	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AFERRID_RS11430	COG1166	arginine decarboxylase activity
AFERRID_RS11465	COG3411	Ferredoxin
AFERRID_RS11480	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AFERRID_RS11510	COG0811	peptide transport
AFERRID_RS11530	COG0725	ABC transporter, periplasmic molybdate-binding protein
AFERRID_RS11540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFERRID_RS11635	COG5420	small protein containing a coiled-coil domain
AFERRID_RS11650	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AFERRID_RS11655	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AFERRID_RS11710	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AFERRID_RS11715	COG0316	Belongs to the HesB IscA family
AFERRID_RS11735	COG5554	nitrogen fixation
AFERRID_RS11745	COG1104	cysteine desulfurase activity
AFERRID_RS11750	COG5554	nitrogen fixation
AFERRID_RS11765	COG0633	Ferredoxin
AFERRID_RS11790	COG1012	belongs to the aldehyde dehydrogenase family
AFERRID_RS11810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFERRID_RS11815	COG0438	transferase activity, transferring glycosyl groups
AFERRID_RS11820	COG0438	transferase activity, transferring glycosyl groups
AFERRID_RS11825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AFERRID_RS11840	COG4974	Belongs to the 'phage' integrase family
AFERRID_RS11870	COG1484	DNA-dependent DNA replication
AFERRID_RS11885	COG0629	single-stranded DNA binding
AFERRID_RS11940	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AFERRID_RS11965	COG0776	regulation of translation
AFERRID_RS11990	COG3077	Addiction module antitoxin, RelB DinJ family
AFERRID_RS12075	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AFERRID_RS12095	COG4962	Type ii secretion system protein e
AFERRID_RS12110	COG3451	type IV secretory pathway VirB4
AFERRID_RS12150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFERRID_RS12170	COG2084	Dehydrogenase
AFERRID_RS12175	COG0243	molybdopterin cofactor binding
AFERRID_RS12185	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AFERRID_RS12195	COG0543	2 iron, 2 sulfur cluster binding
AFERRID_RS12195	COG0633	Ferredoxin
AFERRID_RS12200	COG1151	hydroxylamine reductase activity
AFERRID_RS12215	COG3002	Belongs to the UPF0753 family
AFERRID_RS12220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AFERRID_RS12225	COG0247	lactate metabolic process
AFERRID_RS12230	COG0277	FAD linked oxidase domain protein
AFERRID_RS12235	COG0277	FAD linked oxidase domain protein
AFERRID_RS12270	COG0418	dihydroorotase activity
AFERRID_RS12275	COG0129	dihydroxy-acid dehydratase activity
AFERRID_RS12280	COG0009	L-threonylcarbamoyladenylate synthase
AFERRID_RS12285	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AFERRID_RS12310	COG1192	Involved in chromosome partitioning
AFERRID_RS12325	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AFERRID_RS12330	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AFERRID_RS12335	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AFERRID_RS12365	COG1850	ribulose-bisphosphate carboxylase activity
AFERRID_RS12380	COG3701	Conjugal transfer protein
AFERRID_RS12435	COG3300	MHYT domain
AFERRID_RS12435	COG5001	Diguanylate cyclase
AFERRID_RS12495	COG0625	glutathione transferase activity
AFERRID_RS12510	COG1733	regulation of RNA biosynthetic process
AFERRID_RS12540	COG1475	DNA binding
AFERRID_RS12545	COG1192	Involved in chromosome partitioning
AFERRID_RS12560	COG0667	Aldo Keto reductase
AFERRID_RS12625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AFERRID_RS12630	COG4372	Transposase
AFERRID_RS12685	COG4372	Transposase
AFERRID_RS12730	COG0438	transferase activity, transferring glycosyl groups
AFERRID_RS12735	COG0670	Belongs to the BI1 family
AFERRID_RS12760	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AFERRID_RS12765	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AFERRID_RS12770	COG1428	Deoxynucleoside kinase
AFERRID_RS12780	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AFERRID_RS12780	COG3620	sequence-specific DNA binding
AFERRID_RS12780	COG0617	tRNA 3'-terminal CCA addition
AFERRID_RS12790	COG0463	Glycosyl transferase, family 2
AFERRID_RS12800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AFERRID_RS12800	COG0519	Catalyzes the synthesis of GMP from XMP
AFERRID_RS12850	COG1484	DNA-dependent DNA replication
AFERRID_RS12865	COG0629	single-stranded DNA binding
AFERRID_RS12900	COG0784	Response regulator, receiver
AFERRID_RS12900	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AFERRID_RS12930	COG0776	regulation of translation
AFERRID_RS12940	COG0776	regulation of translation
AFERRID_RS12950	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AFERRID_RS12970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AFERRID_RS12985	COG1215	transferase activity, transferring glycosyl groups
AFERRID_RS13035	COG1671	Belongs to the UPF0178 family
AFERRID_RS13045	COG0776	regulation of translation
AFERRID_RS13050	COG0776	regulation of translation
AFERRID_RS13065	COG0393	Putative heavy-metal-binding
AFERRID_RS13115	COG4372	Transposase
AFERRID_RS13185	COG4962	Type ii secretion system protein e
AFERRID_RS13205	COG3451	type IV secretory pathway VirB4
AFERRID_RS13245	COG4372	Transposase
AFERRID_RS13265	COG3701	Conjugal transfer protein
AFERRID_RS13370	COG0625	glutathione transferase activity
AFERRID_RS13385	COG1733	regulation of RNA biosynthetic process
AFERRID_RS13430	COG1475	DNA binding
AFERRID_RS13435	COG1192	Involved in chromosome partitioning
AFERRID_RS13485	COG3657	addiction module killer protein
AFERRID_RS13490	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AFERRID_RS13505	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AFERRID_RS13520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AFERRID_RS13520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AFERRID_RS13545	COG3384	dioxygenase
AFERRID_RS13550	COG1902	pentaerythritol trinitrate reductase activity
AFERRID_RS13560	COG1741	Belongs to the pirin family
AFERRID_RS13565	COG1733	regulation of RNA biosynthetic process
AFERRID_RS13570	COG0655	NAD(P)H dehydrogenase (quinone) activity
AFERRID_RS13580	COG2259	Doxx family
AFERRID_RS13600	COG0589	response to stress
AFERRID_RS13605	COG4221	oxidoreductase activity
AFERRID_RS13610	COG0667	Aldo Keto reductase
AFERRID_RS13645	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AFERRID_RS13650	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AFERRID_RS13660	COG0243	molybdopterin cofactor binding
AFERRID_RS13675	COG0589	response to stress
AFERRID_RS13680	COG2814	Major facilitator Superfamily
AFERRID_RS13720	COG0531	amino acid
AFERRID_RS13725	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AFERRID_RS13730	COG3264	Mechanosensitive ion channel
AFERRID_RS13730	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AFERRID_RS13745	COG0009	L-threonylcarbamoyladenylate synthase
AFERRID_RS13750	COG1994	Peptidase M50
AFERRID_RS13755	COG0180	Tryptophanyl-tRNA synthetase
AFERRID_RS13760	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AFERRID_RS13765	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AFERRID_RS13775	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFERRID_RS13780	COG1187	pseudouridine synthase activity
AFERRID_RS13785	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AFERRID_RS13800	COG2814	Major facilitator Superfamily
AFERRID_RS13840	COG1105	Belongs to the carbohydrate kinase PfkB family
AFERRID_RS13845	COG0280	phosphate acetyltransferase
AFERRID_RS13850	COG0477	Major facilitator Superfamily
AFERRID_RS13855	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AFERRID_RS13860	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFERRID_RS13865	COG0022	dehydrogenase e1 component
AFERRID_RS13870	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AFERRID_RS13880	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AFERRID_RS13885	COG0574	Belongs to the PEP-utilizing enzyme family
AFERRID_RS13885	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFERRID_RS13900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFERRID_RS13905	COG2171	N-acyltransferase activity
AFERRID_RS13920	COG0546	phosphoglycolate phosphatase activity
AFERRID_RS13925	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AFERRID_RS13930	COG0402	S-adenosylhomocysteine deaminase activity
AFERRID_RS13940	COG0791	NLP P60 protein
AFERRID_RS13985	COG0732	type I restriction modification DNA specificity domain
AFERRID_RS14020	COG0596	Alpha beta hydrolase
AFERRID_RS14035	COG3153	acetyltransferase
AFERRID_RS14085	COG4372	Transposase
AFERRID_RS14120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AFERRID_RS14135	COG0587	DNA-directed DNA polymerase activity
AFERRID_RS14145	COG0308	aminopeptidase N
AFERRID_RS14160	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AFERRID_RS14170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFERRID_RS14175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFERRID_RS14190	COG0424	maF-like protein
AFERRID_RS14195	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AFERRID_RS14200	COG1923	regulation of RNA biosynthetic process
AFERRID_RS14205	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AFERRID_RS14210	COG0330	HflC and HflK could
AFERRID_RS14215	COG0330	HflC and HflK could
AFERRID_RS14250	COG1546	Belongs to the CinA family
AFERRID_RS14250	COG1058	Belongs to the CinA family
AFERRID_RS14255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AFERRID_RS14260	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AFERRID_RS14275	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AFERRID_RS14290	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AFERRID_RS14295	COG0416	fatty acid biosynthetic process
AFERRID_RS14300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFERRID_RS14315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AFERRID_RS14320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AFERRID_RS14330	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AFERRID_RS14335	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AFERRID_RS14365	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AFERRID_RS14370	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AFERRID_RS14375	COG0004	ammonium transporteR
AFERRID_RS14380	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AFERRID_RS14380	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AFERRID_RS14395	COG0802	atpase or kinase
AFERRID_RS14400	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AFERRID_RS14405	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AFERRID_RS14410	COG0105	UTP biosynthetic process
AFERRID_RS14415	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AFERRID_RS14425	COG1426	Protein conserved in bacteria
AFERRID_RS14430	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AFERRID_RS14435	COG0124	histidyl-tRNA synthetase
AFERRID_RS14490	COG0730	response to heat
AFERRID_RS14585	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFERRID_RS14600	COG1881	PFAM PEBP family protein
AFERRID_RS14605	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AFERRID_RS14630	COG1216	Glycosyl transferase, family 2
AFERRID_RS14655	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AFERRID_RS14660	COG1028	Short-chain dehydrogenase reductase Sdr
AFERRID_RS14695	COG0729	surface antigen
AFERRID_RS14715	COG4654	Cytochrome c, class I
AFERRID_RS14740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFERRID_RS14750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFERRID_RS14765	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AFERRID_RS14770	COG1469	GTP cyclohydrolase I activity
AFERRID_RS14775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AFERRID_RS14780	COG0142	geranyltranstransferase activity
AFERRID_RS14790	COG2223	nitrite transmembrane transporter activity
AFERRID_RS14800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFERRID_RS14805	COG1570	exodeoxyribonuclease VII activity
AFERRID_RS14810	COG4993	Dehydrogenase
AFERRID_RS14810	COG2010	Cytochrome c
AFERRID_RS14820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AFERRID_RS14825	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AFERRID_RS14830	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AFERRID_RS14835	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFERRID_RS14855	COG0583	DNA-binding transcription factor activity
AFERRID_RS14860	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFERRID_RS14870	COG2197	response regulator
AFERRID_RS14880	COG3916	Acyl-homoserine-lactone synthase
AFERRID_RS14930	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AFERRID_RS14970	COG2217	Heavy metal translocating P-type atpase
AFERRID_RS14975	COG0436	Aminotransferase
AFERRID_RS14990	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AFERRID_RS14995	COG0640	Transcriptional regulator
AFERRID_RS15000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AFERRID_RS15020	COG3504	Conjugal transfer protein
AFERRID_RS15040	COG3846	protein secretion by the type IV secretion system