locus-tag	class	description
K1Y48_RS00025	COG0436	Aminotransferase
K1Y48_RS00035	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K1Y48_RS00040	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K1Y48_RS00045	COG0640	Transcriptional regulator
K1Y48_RS00050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K1Y48_RS00090	COG0322	excinuclease ABC activity
K1Y48_RS00100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K1Y48_RS00105	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K1Y48_RS00110	COG0148	phosphopyruvate hydratase activity
K1Y48_RS00115	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K1Y48_RS00120	COG0504	CTP synthase activity
K1Y48_RS00125	COG1064	alcohol dehydrogenase
K1Y48_RS00180	COG0477	Major facilitator Superfamily
K1Y48_RS00190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K1Y48_RS00190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K1Y48_RS00195	COG1230	cation diffusion facilitator family transporter
K1Y48_RS00200	COG2226	methyltransferase
K1Y48_RS00240	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
K1Y48_RS00250	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
K1Y48_RS00270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K1Y48_RS00275	COG1215	transferase activity, transferring glycosyl groups
K1Y48_RS00280	COG1215	transferase activity, transferring glycosyl groups
K1Y48_RS00290	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K1Y48_RS00295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K1Y48_RS00300	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K1Y48_RS00305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K1Y48_RS00310	COG0037	tRNA processing
K1Y48_RS00315	COG0825	malonyl-CoA metabolic process
K1Y48_RS00325	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K1Y48_RS00330	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K1Y48_RS00340	COG0673	inositol 2-dehydrogenase activity
K1Y48_RS00345	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K1Y48_RS00350	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K1Y48_RS00355	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K1Y48_RS00375	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K1Y48_RS00380	COG0575	Belongs to the CDS family
K1Y48_RS00395	COG0528	UMP kinase activity
K1Y48_RS00400	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K1Y48_RS00405	COG0052	Belongs to the universal ribosomal protein uS2 family
K1Y48_RS00410	COG0586	Pfam SNARE associated Golgi protein
K1Y48_RS00420	COG0248	Ppx GppA phosphatase
K1Y48_RS00425	COG0704	Plays a role in the regulation of phosphate uptake
K1Y48_RS00430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K1Y48_RS00445	COG0513	Belongs to the DEAD box helicase family
K1Y48_RS00465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K1Y48_RS00470	COG1862	Preprotein translocase
K1Y48_RS00475	COG0343	queuine tRNA-ribosyltransferase activity
K1Y48_RS00480	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K1Y48_RS00485	COG1253	flavin adenine dinucleotide binding
K1Y48_RS00500	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K1Y48_RS00510	COG0285	dihydrofolate synthase activity
K1Y48_RS00515	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K1Y48_RS00520	COG0159	tryptophan synthase activity
K1Y48_RS00525	COG0133	tryptophan synthase activity
K1Y48_RS00530	COG0135	phosphoribosylanthranilate isomerase activity
K1Y48_RS00535	COG0101	tRNA pseudouridine synthase activity
K1Y48_RS00545	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K1Y48_RS00560	COG0746	molybdenum cofactor guanylyltransferase activity
K1Y48_RS00565	COG1763	Mo-molybdopterin cofactor biosynthetic process
K1Y48_RS00580	COG0303	'Molybdopterin
K1Y48_RS00595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K1Y48_RS00605	COG2078	PFAM AMMECR1 domain protein
K1Y48_RS00610	COG1355	regulation of microtubule-based process
K1Y48_RS00635	COG0628	permease
K1Y48_RS00665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K1Y48_RS00680	COG1561	YicC-like family, N-terminal region
K1Y48_RS00705	COG1850	ribulose-bisphosphate carboxylase activity
K1Y48_RS00725	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K1Y48_RS00730	COG0154	amidase activity
K1Y48_RS00735	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K1Y48_RS00740	COG2853	Lipoprotein
K1Y48_RS00750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K1Y48_RS00765	COG3394	polysaccharide catabolic process
K1Y48_RS00780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K1Y48_RS00790	COG1657	PFAM Prenyltransferase squalene oxidase
K1Y48_RS00795	COG1562	ergosterol biosynthetic process
K1Y48_RS00800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K1Y48_RS00805	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K1Y48_RS00840	COG0442	prolyl-tRNA aminoacylation
K1Y48_RS00860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K1Y48_RS00870	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K1Y48_RS00890	COG0768	penicillin binding
K1Y48_RS00895	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K1Y48_RS00900	COG0193	aminoacyl-tRNA hydrolase activity
K1Y48_RS00905	COG0012	GTP binding
K1Y48_RS00920	COG1649	PFAM Uncharacterised BCR, COG1649
K1Y48_RS00920	COG0726	polysaccharide deacetylase
K1Y48_RS00930	COG0494	nUDIX hydrolase
K1Y48_RS00940	COG1187	pseudouridine synthase activity
K1Y48_RS00945	COG2957	Belongs to the agmatine deiminase family
K1Y48_RS00955	COG0210	DNA helicase
K1Y48_RS00960	COG0268	Binds directly to 16S ribosomal RNA
K1Y48_RS00965	COG3842	ATPase activity
K1Y48_RS00980	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K1Y48_RS00985	COG0514	ATP-dependent DNA helicase (RecQ)
K1Y48_RS00990	COG1965	Belongs to the frataxin family
K1Y48_RS01015	COG0795	lipopolysaccharide-transporting ATPase activity
K1Y48_RS01020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K1Y48_RS01025	COG2927	DNA polymerase III (CHI subunit)
K1Y48_RS01035	COG0525	valine-tRNA ligase activity
K1Y48_RS01040	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K1Y48_RS01055	COG0412	Dienelactone hydrolase
K1Y48_RS01060	COG1902	pentaerythritol trinitrate reductase activity
K1Y48_RS01090	COG2917	probably involved in intracellular septation
K1Y48_RS01095	COG2350	Protein conserved in bacteria
K1Y48_RS01100	COG0271	Belongs to the BolA IbaG family
K1Y48_RS01105	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K1Y48_RS01105	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K1Y48_RS01115	COG0129	dihydroxy-acid dehydratase activity
K1Y48_RS01120	COG0628	permease
K1Y48_RS01125	COG0281	malic enzyme
K1Y48_RS01125	COG0280	phosphate acetyltransferase
K1Y48_RS01130	COG0254	rRNA binding
K1Y48_RS01155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K1Y48_RS01175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K1Y48_RS01180	COG1127	ABC transporter
K1Y48_RS01185	COG0163	prenyltransferase activity
K1Y48_RS01190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K1Y48_RS01200	COG2022	thiamine diphosphate biosynthetic process
K1Y48_RS01210	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K1Y48_RS01225	COG1752	Esterase of the alpha-beta hydrolase superfamily
K1Y48_RS01230	COG0482	sulfurtransferase activity
K1Y48_RS01245	COG0443	Heat shock 70 kDa protein
K1Y48_RS01250	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K1Y48_RS01260	COG0822	iron-sulfur transferase activity
K1Y48_RS01265	COG1104	cysteine desulfurase activity
K1Y48_RS01270	COG1959	2 iron, 2 sulfur cluster binding
K1Y48_RS01290	COG5001	Diguanylate cyclase
K1Y48_RS01290	COG3300	MHYT domain
K1Y48_RS01305	COG1530	ribonuclease E activity
K1Y48_RS01310	COG0215	cysteine-tRNA ligase activity
K1Y48_RS01315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K1Y48_RS01325	COG3300	MHYT domain
K1Y48_RS01325	COG5001	Diguanylate cyclase
K1Y48_RS01335	COG0531	amino acid
K1Y48_RS01365	COG2205	protein histidine kinase activity
K1Y48_RS01375	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K1Y48_RS01385	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K1Y48_RS01400	COG0138	bifunctional purine biosynthesis protein purh
K1Y48_RS01405	COG0151	Belongs to the GarS family
K1Y48_RS01410	COG0009	L-threonylcarbamoyladenylate synthase
K1Y48_RS01415	COG0408	coproporphyrinogen oxidase activity
K1Y48_RS01420	COG0167	dihydroorotate dehydrogenase activity
K1Y48_RS01450	COG0811	peptide transport
K1Y48_RS01480	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K1Y48_RS01490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K1Y48_RS01510	COG0033	Phosphoglucomutase
K1Y48_RS01590	COG1845	cytochrome c oxidase, subunit III
K1Y48_RS01595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K1Y48_RS01600	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K1Y48_RS01615	COG0505	Belongs to the CarA family
K1Y48_RS01625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K1Y48_RS01630	COG1968	undecaprenyl-diphosphatase activity
K1Y48_RS01635	COG2814	Major facilitator Superfamily
K1Y48_RS01640	COG0109	protoheme IX farnesyltransferase activity
K1Y48_RS01655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K1Y48_RS01660	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K1Y48_RS01675	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K1Y48_RS01680	COG0259	pyridoxamine-phosphate oxidase activity
K1Y48_RS01690	COG0066	3-isopropylmalate dehydratase activity
K1Y48_RS01695	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K1Y48_RS01700	COG2226	methyltransferase
K1Y48_RS01730	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K1Y48_RS01735	COG1132	(ABC) transporter
K1Y48_RS01740	COG0438	transferase activity, transferring glycosyl groups
K1Y48_RS01745	COG0438	transferase activity, transferring glycosyl groups
K1Y48_RS01790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K1Y48_RS01800	COG1121	(ABC) transporter
K1Y48_RS01810	COG0312	modulator of DNA gyrase
K1Y48_RS01815	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K1Y48_RS01820	COG4535	Mg2 and Co2 transporter CorC
K1Y48_RS01825	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K1Y48_RS01830	COG1702	phosphate starvation-inducible protein PhoH
K1Y48_RS01835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K1Y48_RS01840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K1Y48_RS01850	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K1Y48_RS01855	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K1Y48_RS01860	COG1278	Cold shock
K1Y48_RS01910	COG0776	regulation of translation
K1Y48_RS01915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K1Y48_RS01915	COG0072	phenylalanine-tRNA ligase activity
K1Y48_RS01920	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K1Y48_RS01925	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K1Y48_RS01930	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K1Y48_RS01935	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K1Y48_RS01940	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K1Y48_RS01955	COG1007	ATP synthesis coupled electron transport
K1Y48_RS01970	COG0713	ATP synthesis coupled electron transport
K1Y48_RS01980	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K1Y48_RS01985	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K1Y48_RS01990	COG1034	ATP synthesis coupled electron transport
K1Y48_RS02000	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
K1Y48_RS02005	COG0649	NAD binding
K1Y48_RS02010	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K1Y48_RS02015	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K1Y48_RS02020	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K1Y48_RS02035	COG0149	triose-phosphate isomerase activity
K1Y48_RS02040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K1Y48_RS02045	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K1Y48_RS02050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K1Y48_RS02055	COG0312	modulator of DNA gyrase
K1Y48_RS02060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K1Y48_RS02060	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K1Y48_RS02065	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K1Y48_RS02070	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K1Y48_RS02075	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K1Y48_RS02080	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K1Y48_RS02085	COG1061	Type III restriction enzyme res subunit
K1Y48_RS02095	COG1002	Type II restriction enzyme, methylase subunits
K1Y48_RS02160	COG4974	Belongs to the 'phage' integrase family
K1Y48_RS02185	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K1Y48_RS02205	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K1Y48_RS02210	COG2835	tetraacyldisaccharide 4'-kinase activity
K1Y48_RS02215	COG1663	tetraacyldisaccharide 4'-kinase activity
K1Y48_RS02230	COG0848	biopolymer transport protein
K1Y48_RS02235	COG0811	peptide transport
K1Y48_RS02240	COG2333	competence protein COMEC
K1Y48_RS02240	COG0658	competence protein
K1Y48_RS02250	COG1136	(ABC) transporter
K1Y48_RS02275	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K1Y48_RS02285	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K1Y48_RS02295	COG0436	Aminotransferase
K1Y48_RS02310	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K1Y48_RS02315	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K1Y48_RS02340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K1Y48_RS02345	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
K1Y48_RS02350	COG0495	leucyl-tRNA aminoacylation
K1Y48_RS02360	COG1466	dna polymerase III delta subunit
K1Y48_RS02370	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K1Y48_RS02375	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K1Y48_RS02375	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K1Y48_RS02380	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K1Y48_RS02385	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K1Y48_RS02390	COG0497	DNA recombination
K1Y48_RS02395	COG2205	protein histidine kinase activity
K1Y48_RS02405	COG2204	response regulator
K1Y48_RS02415	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K1Y48_RS02530	COG0242	peptide deformylase activity
K1Y48_RS02540	COG0235	Class ii aldolase
K1Y48_RS02545	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
K1Y48_RS02550	COG1850	ribulose-bisphosphate carboxylase activity
K1Y48_RS02555	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
K1Y48_RS02580	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K1Y48_RS02580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K1Y48_RS02585	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K1Y48_RS02595	COG0045	succinate-CoA ligase (ADP-forming) activity
K1Y48_RS02600	COG0538	isocitrate dehydrogenase activity
K1Y48_RS02605	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K1Y48_RS02610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K1Y48_RS02615	COG1388	LysM domain
K1Y48_RS02615	COG0741	lytic transglycosylase activity
K1Y48_RS02625	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K1Y48_RS02630	COG0583	DNA-binding transcription factor activity
K1Y48_RS02645	COG2863	cytochrome
K1Y48_RS02650	COG1028	Short-chain dehydrogenase reductase Sdr
K1Y48_RS02655	COG0723	plastoquinol--plastocyanin reductase activity
K1Y48_RS02660	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K1Y48_RS02690	COG0717	Belongs to the dCTP deaminase family
K1Y48_RS02695	COG0489	protein tyrosine kinase activity
K1Y48_RS02705	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K1Y48_RS02710	COG0484	heat shock protein binding
K1Y48_RS02720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K1Y48_RS02725	COG1420	regulation of RNA biosynthetic process
K1Y48_RS02730	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K1Y48_RS02735	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K1Y48_RS02740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K1Y48_RS02740	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K1Y48_RS02745	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K1Y48_RS02750	COG0114	fumarate hydratase activity
K1Y48_RS02775	COG0297	glycogen (starch) synthase activity
K1Y48_RS02780	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K1Y48_RS02790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K1Y48_RS02810	COG0543	2 iron, 2 sulfur cluster binding
K1Y48_RS02810	COG0633	Ferredoxin
K1Y48_RS02815	COG1151	hydroxylamine reductase activity
K1Y48_RS02825	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K1Y48_RS02830	COG1534	Rna-binding protein
K1Y48_RS02835	COG2967	ApaG domain
K1Y48_RS02840	COG2226	methyltransferase
K1Y48_RS02860	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K1Y48_RS02875	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K1Y48_RS02880	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K1Y48_RS02885	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K1Y48_RS02900	COG2177	Part of the ABC transporter FtsEX involved in
K1Y48_RS02905	COG2884	Cell division ATP-binding protein ftsE
K1Y48_RS02910	COG0552	protein localization to endoplasmic reticulum
K1Y48_RS02915	COG0742	ribosomal rna small subunit methyltransferase
K1Y48_RS02920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K1Y48_RS02925	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K1Y48_RS02930	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K1Y48_RS02935	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K1Y48_RS02940	COG2890	protein-(glutamine-N5) methyltransferase activity
K1Y48_RS02945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K1Y48_RS02950	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K1Y48_RS02965	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K1Y48_RS02975	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K1Y48_RS02985	COG0326	Molecular chaperone. Has ATPase activity
K1Y48_RS03000	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
K1Y48_RS03015	COG0006	proline dipeptidase activity
K1Y48_RS03030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K1Y48_RS03035	COG0305	Participates in initiation and elongation during chromosome replication
K1Y48_RS03040	COG0359	binds to the 23S rRNA
K1Y48_RS03055	COG0360	Binds together with S18 to 16S ribosomal RNA
K1Y48_RS03060	COG1472	Belongs to the glycosyl hydrolase 3 family
K1Y48_RS03065	COG0531	amino acid
K1Y48_RS03075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K1Y48_RS03100	COG0363	glucosamine-6-phosphate deaminase activity
K1Y48_RS03115	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K1Y48_RS03120	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K1Y48_RS03130	COG1449	Belongs to the glycosyl hydrolase 57 family
K1Y48_RS03135	COG1940	carbohydrate kinase activity
K1Y48_RS03140	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K1Y48_RS03145	COG2733	membrane
K1Y48_RS03155	COG0629	single-stranded DNA binding
K1Y48_RS03170	COG3118	belongs to the thioredoxin family
K1Y48_RS03175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K1Y48_RS03190	COG0335	large ribosomal subunit rRNA binding
K1Y48_RS03195	COG0336	Belongs to the RNA methyltransferase TrmD family
K1Y48_RS03200	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K1Y48_RS03205	COG0228	four-way junction DNA binding
K1Y48_RS03210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K1Y48_RS03225	COG3002	Belongs to the UPF0753 family
K1Y48_RS03230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K1Y48_RS03235	COG0583	DNA-binding transcription factor activity
K1Y48_RS03335	COG1573	uracil-dna glycosylase
K1Y48_RS03345	COG0488	(ABC) transporter
K1Y48_RS03375	COG0142	geranyltranstransferase activity
K1Y48_RS03390	COG3852	Histidine kinase
K1Y48_RS03400	COG2308	Evidence 4 Homologs of previously reported genes of
K1Y48_RS03425	COG2766	serine protein kinase
K1Y48_RS03435	COG2718	Belongs to the UPF0229 family
K1Y48_RS03440	COG2719	SpoVR family
K1Y48_RS03450	COG0347	Belongs to the P(II) protein family
K1Y48_RS03455	COG0004	ammonium transporteR
K1Y48_RS03470	COG0004	ammonium transporteR
K1Y48_RS03480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K1Y48_RS03480	COG0519	Catalyzes the synthesis of GMP from XMP
K1Y48_RS03505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K1Y48_RS03530	COG1686	Belongs to the peptidase S11 family
K1Y48_RS03535	COG0166	Belongs to the GPI family
K1Y48_RS03550	COG0165	Argininosuccinate lyase
K1Y48_RS03585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K1Y48_RS03600	COG1970	mechanosensitive ion channel activity
K1Y48_RS03605	COG1322	Protein conserved in bacteria
K1Y48_RS03610	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K1Y48_RS03615	COG0598	Magnesium transport protein CorA
K1Y48_RS03620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K1Y48_RS03630	COG0483	inositol monophosphate 1-phosphatase activity
K1Y48_RS03635	COG1494	fructose-1,6-bisphosphatase
K1Y48_RS03640	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K1Y48_RS03645	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K1Y48_RS03650	COG0126	phosphoglycerate kinase activity
K1Y48_RS03655	COG0469	pyruvate kinase activity
K1Y48_RS03665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K1Y48_RS03670	COG0546	phosphoglycolate phosphatase activity
K1Y48_RS03685	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K1Y48_RS03690	COG0134	indole-3-glycerol-phosphate synthase activity
K1Y48_RS03700	COG1959	2 iron, 2 sulfur cluster binding
K1Y48_RS03705	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
K1Y48_RS03715	COG2945	thiolester hydrolase activity
K1Y48_RS03720	COG1131	(ABC) transporter
K1Y48_RS03735	COG0582	viral genome integration into host DNA
K1Y48_RS03795	COG3437	response regulator, receiver
K1Y48_RS03800	COG0784	Response regulator, receiver
K1Y48_RS03810	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K1Y48_RS03815	COG0706	membrane insertase activity
K1Y48_RS03820	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K1Y48_RS03830	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K1Y48_RS03835	COG0488	(ABC) transporter
K1Y48_RS03840	COG1566	PFAM secretion protein HlyD family protein
K1Y48_RS03860	COG2095	MarC family integral membrane protein
K1Y48_RS03870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K1Y48_RS03875	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K1Y48_RS03885	COG0217	transcriptional regulatory protein
K1Y48_RS03890	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K1Y48_RS03895	COG0632	four-way junction helicase activity
K1Y48_RS03900	COG2255	four-way junction helicase activity
K1Y48_RS03905	COG0824	Thioesterase
K1Y48_RS03910	COG0811	peptide transport
K1Y48_RS03925	COG0823	Involved in the tonB-independent uptake of proteins
K1Y48_RS03930	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K1Y48_RS03935	COG0602	queuosine metabolic process
K1Y48_RS03945	COG2885	chlorophyll binding
K1Y48_RS03970	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K1Y48_RS04000	COG1216	Glycosyl transferase, family 2
K1Y48_RS04040	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K1Y48_RS04050	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K1Y48_RS04060	COG3220	belongs to the UPF0276 family
K1Y48_RS04070	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K1Y48_RS04075	COG1074	ATP-dependent DNA helicase activity
K1Y48_RS04080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K1Y48_RS04110	COG0811	peptide transport
K1Y48_RS04125	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
K1Y48_RS04140	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K1Y48_RS04150	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K1Y48_RS04160	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K1Y48_RS04175	COG0424	maF-like protein
K1Y48_RS04180	COG1530	ribonuclease E activity
K1Y48_RS04195	COG1278	Cold shock
K1Y48_RS04200	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K1Y48_RS04205	COG1333	cytochrome c biogenesis protein
K1Y48_RS04210	COG1858	cytochrome C peroxidase
K1Y48_RS04295	COG3328	transposase activity
K1Y48_RS04345	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K1Y48_RS04355	COG2815	serine threonine protein kinase
K1Y48_RS04355	COG0515	serine threonine protein kinase
K1Y48_RS04420	COG0792	nuclease activity
K1Y48_RS04425	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K1Y48_RS04430	COG0277	FAD linked oxidase domain protein
K1Y48_RS04450	COG0583	DNA-binding transcription factor activity
K1Y48_RS04465	COG2188	Transcriptional regulator
K1Y48_RS04485	COG0493	'glutamate synthase
K1Y48_RS04485	COG0543	2 iron, 2 sulfur cluster binding
K1Y48_RS04490	COG4521	taurine ABC transporter
K1Y48_RS04495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K1Y48_RS04520	COG0393	Putative heavy-metal-binding
K1Y48_RS04525	COG1842	Phage shock protein A
K1Y48_RS04530	COG1914	H( )-stimulated, divalent metal cation uptake system
K1Y48_RS04555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K1Y48_RS04580	COG3549	Plasmid maintenance system killer
K1Y48_RS04590	COG4115	mRNA cleavage
K1Y48_RS04595	COG2161	toxin-antitoxin pair type II binding
K1Y48_RS04600	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K1Y48_RS04605	COG2833	Protein of unknown function (DUF455)
K1Y48_RS04610	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K1Y48_RS04615	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K1Y48_RS04620	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K1Y48_RS04625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K1Y48_RS04645	COG1393	Belongs to the ArsC family
K1Y48_RS04655	COG3459	Glycosyltransferase 36 associated
K1Y48_RS04665	COG2204	response regulator
K1Y48_RS04670	COG5000	phosphorelay sensor kinase activity
K1Y48_RS04680	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K1Y48_RS04685	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K1Y48_RS04690	COG0242	peptide deformylase activity
K1Y48_RS04700	COG0758	DNA mediated transformation
K1Y48_RS04705	COG2922	Belongs to the Smg family
K1Y48_RS04715	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K1Y48_RS04720	COG0850	regulation of cytokinetic process
K1Y48_RS04730	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K1Y48_RS04740	COG3409	Peptidoglycan-binding domain 1 protein
K1Y48_RS04740	COG3267	Type II secretory pathway component ExeA
K1Y48_RS04790	COG2165	general secretion pathway protein
K1Y48_RS04795	COG1459	type II secretion system
K1Y48_RS04800	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K1Y48_RS04805	COG0543	2 iron, 2 sulfur cluster binding
K1Y48_RS04805	COG0493	'glutamate synthase
K1Y48_RS04815	COG0187	DNA topoisomerase II activity
K1Y48_RS04820	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K1Y48_RS04825	COG0592	DNA-directed DNA polymerase activity
K1Y48_RS04830	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K1Y48_RS04855	COG1028	Short-chain dehydrogenase reductase Sdr
K1Y48_RS04860	COG0723	plastoquinol--plastocyanin reductase activity
K1Y48_RS04865	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K1Y48_RS04870	COG2857	Cytochrome c1
K1Y48_RS04885	COG0351	phosphomethylpyrimidine kinase
K1Y48_RS04890	COG0352	thiamine-phosphate diphosphorylase activity
K1Y48_RS04895	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K1Y48_RS04900	COG0537	adenosine 5'-monophosphoramidase activity
K1Y48_RS04910	COG0181	hydroxymethylbilane synthase activity
K1Y48_RS04920	COG0113	porphobilinogen synthase activity
K1Y48_RS04930	COG0477	Major facilitator Superfamily
K1Y48_RS04945	COG1091	dTDP-4-dehydrorhamnose reductase activity
K1Y48_RS04950	COG1088	dTDP-glucose 4,6-dehydratase activity
K1Y48_RS04960	COG2337	Toxic component of a toxin-antitoxin (TA) module
K1Y48_RS04985	COG3093	addiction module antidote protein HigA
K1Y48_RS05025	COG0277	FAD linked oxidase domain protein
K1Y48_RS05030	COG0277	FAD linked oxidase domain protein
K1Y48_RS05035	COG0247	lactate metabolic process
K1Y48_RS05065	COG0521	Mo-molybdopterin cofactor biosynthetic process
K1Y48_RS05075	COG0445	tRNA wobble uridine modification
K1Y48_RS05080	COG0357	Ribosomal RNA small subunit methyltransferase G
K1Y48_RS05085	COG1192	Involved in chromosome partitioning
K1Y48_RS05090	COG1475	DNA binding
K1Y48_RS05100	COG0356	it plays a direct role in the translocation of protons across the membrane
K1Y48_RS05110	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K1Y48_RS05115	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K1Y48_RS05120	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K1Y48_RS05125	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K1Y48_RS05140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K1Y48_RS05175	COG4974	Belongs to the 'phage' integrase family
K1Y48_RS05180	COG0517	IMP dehydrogenase activity
K1Y48_RS05210	COG2336	PFAM SpoVT AbrB
K1Y48_RS05215	COG2226	methyltransferase
K1Y48_RS05230	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K1Y48_RS05240	COG3300	MHYT domain
K1Y48_RS05240	COG5001	Diguanylate cyclase
K1Y48_RS05250	COG1815	bacterial-type flagellum-dependent cell motility
K1Y48_RS05260	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K1Y48_RS05265	COG1749	Flagellar hook protein flgE
K1Y48_RS05280	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K1Y48_RS05285	COG1706	bacterial-type flagellum-dependent cell motility
K1Y48_RS05290	COG1705	Flagellar rod assembly protein muramidase FlgJ
K1Y48_RS05290	COG3951	Flagellar rod assembly protein muramidase FlgJ
K1Y48_RS05295	COG1256	bacterial-type flagellum assembly
K1Y48_RS05340	COG1677	Flagellar hook-basal body complex protein FliE
K1Y48_RS05380	COG1191	sigma factor activity
K1Y48_RS05415	COG1987	bacterial-type flagellum assembly
K1Y48_RS05425	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K1Y48_RS05430	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K1Y48_RS05460	COG2198	Histidine kinase
K1Y48_RS05460	COG0643	Histidine kinase
K1Y48_RS05480	COG0784	Response regulator, receiver
K1Y48_RS05480	COG0835	chemotaxis
K1Y48_RS05525	COG1196	nuclear chromosome segregation
K1Y48_RS05555	COG2814	Major facilitator Superfamily
K1Y48_RS05575	COG0667	Aldo Keto reductase
K1Y48_RS05600	COG2336	PFAM SpoVT AbrB
K1Y48_RS05615	COG0038	chloride channel
K1Y48_RS05675	COG3409	Peptidoglycan-binding domain 1 protein
K1Y48_RS05675	COG3267	Type II secretory pathway component ExeA
K1Y48_RS05725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K1Y48_RS05740	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K1Y48_RS05760	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
K1Y48_RS05770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K1Y48_RS05775	COG3344	reverse transcriptase
K1Y48_RS05805	COG3344	reverse transcriptase
K1Y48_RS05835	COG4232	protein-disulfide reductase activity
K1Y48_RS05845	COG1595	DNA-templated transcription, initiation
K1Y48_RS05870	COG3220	belongs to the UPF0276 family
K1Y48_RS05900	COG0789	Transcriptional regulator
K1Y48_RS05970	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K1Y48_RS05995	COG0446	pyridine nucleotide-disulphide oxidoreductase
K1Y48_RS06020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K1Y48_RS06025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K1Y48_RS06030	COG0583	DNA-binding transcription factor activity
K1Y48_RS06045	COG2814	Major facilitator Superfamily
K1Y48_RS06065	COG0076	glutamate decarboxylase activity
K1Y48_RS06070	COG0531	amino acid
K1Y48_RS06075	COG0531	amino acid
K1Y48_RS06090	COG2995	paraquat-inducible protein a
K1Y48_RS06140	COG1028	Short-chain dehydrogenase reductase Sdr
K1Y48_RS06220	COG2336	PFAM SpoVT AbrB
K1Y48_RS06250	COG0784	Response regulator, receiver
K1Y48_RS06250	COG3437	response regulator, receiver
K1Y48_RS06285	COG1733	regulation of RNA biosynthetic process
K1Y48_RS06290	COG0655	NAD(P)H dehydrogenase (quinone) activity
K1Y48_RS06295	COG2353	YceI-like domain
K1Y48_RS06300	COG3384	dioxygenase
K1Y48_RS06335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K1Y48_RS06340	COG1671	Belongs to the UPF0178 family
K1Y48_RS06375	COG0640	Transcriptional regulator
K1Y48_RS06425	COG0418	dihydroorotase activity
K1Y48_RS06430	COG0129	dihydroxy-acid dehydratase activity
K1Y48_RS06435	COG0191	fructose-bisphosphate aldolase activity
K1Y48_RS06450	COG1192	Involved in chromosome partitioning
K1Y48_RS06465	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
K1Y48_RS06470	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
K1Y48_RS06475	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
K1Y48_RS06515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K1Y48_RS06545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K1Y48_RS06550	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K1Y48_RS06550	COG1796	DNA polymerase
K1Y48_RS06570	COG0210	DNA helicase
K1Y48_RS06575	COG1555	photosystem II stabilization
K1Y48_RS06580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K1Y48_RS06590	COG1611	Belongs to the LOG family
K1Y48_RS06595	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K1Y48_RS06595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K1Y48_RS06600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K1Y48_RS06610	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K1Y48_RS06615	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K1Y48_RS06650	COG0778	Nitroreductase
K1Y48_RS06660	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K1Y48_RS06665	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K1Y48_RS06670	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K1Y48_RS06685	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K1Y48_RS06690	COG0022	dehydrogenase e1 component
K1Y48_RS06690	COG0508	dehydrogenase complex catalyzes the overall conversion of
K1Y48_RS06700	COG0316	Belongs to the HesB IscA family
K1Y48_RS06715	COG0189	ligase activity
K1Y48_RS06720	COG1678	Uncharacterized ACR, COG1678
K1Y48_RS06725	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K1Y48_RS06730	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
K1Y48_RS06735	COG0540	Belongs to the ATCase OTCase family
K1Y48_RS06760	COG3158	transport of potassium into the cell
K1Y48_RS06770	COG0805	protein transport
K1Y48_RS06775	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K1Y48_RS06780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K1Y48_RS06785	COG0140	phosphoribosyl-ATP diphosphatase activity
K1Y48_RS06785	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K1Y48_RS06790	COG0107	imidazoleglycerol-phosphate synthase activity
K1Y48_RS06795	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K1Y48_RS06800	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K1Y48_RS06805	COG0131	Imidazoleglycerol-phosphate dehydratase
K1Y48_RS06810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K1Y48_RS06815	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K1Y48_RS06820	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K1Y48_RS06825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K1Y48_RS06830	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K1Y48_RS06835	COG0271	Belongs to the BolA IbaG family
K1Y48_RS06840	COG0842	Transport permease protein
K1Y48_RS06845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K1Y48_RS06850	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K1Y48_RS06855	COG3178	'Phosphotransferase
K1Y48_RS06860	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K1Y48_RS06880	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K1Y48_RS06910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K1Y48_RS06910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K1Y48_RS06910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1Y48_RS06915	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K1Y48_RS06920	COG1660	Displays ATPase and GTPase activities
K1Y48_RS06935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K1Y48_RS06945	COG1194	a g-specific adenine glycosylase
K1Y48_RS06950	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K1Y48_RS06955	COG2205	protein histidine kinase activity
K1Y48_RS06965	COG2204	response regulator
K1Y48_RS06970	COG2062	phosphohistidine phosphatase, SixA
K1Y48_RS06975	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K1Y48_RS06980	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K1Y48_RS06985	COG1127	ABC transporter
K1Y48_RS06990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K1Y48_RS06995	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K1Y48_RS07010	COG1131	(ABC) transporter
K1Y48_RS07015	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K1Y48_RS07020	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K1Y48_RS07030	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K1Y48_RS07045	COG0018	arginyl-trna synthetase
K1Y48_RS07050	COG3264	Mechanosensitive ion channel
K1Y48_RS07050	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K1Y48_RS07065	COG0708	Exodeoxyribonuclease III
K1Y48_RS07075	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K1Y48_RS07080	COG0625	glutathione transferase activity
K1Y48_RS07090	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K1Y48_RS07095	COG1047	Peptidyl-prolyl cis-trans
K1Y48_RS07100	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K1Y48_RS07105	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K1Y48_RS07110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K1Y48_RS07130	COG0237	dephospho-CoA kinase activity
K1Y48_RS07135	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K1Y48_RS07140	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K1Y48_RS07200	COG1028	Short-chain dehydrogenase reductase Sdr
K1Y48_RS07205	COG0475	glutathione-regulated potassium exporter activity
K1Y48_RS07235	COG2969	positive regulation of protein catabolic process
K1Y48_RS07240	COG0739	heme binding
K1Y48_RS07240	COG0741	lytic transglycosylase activity
K1Y48_RS07240	COG1196	nuclear chromosome segregation
K1Y48_RS07245	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K1Y48_RS07255	COG2264	protein methyltransferase activity
K1Y48_RS07260	COG0439	Biotin carboxylase
K1Y48_RS07265	COG0511	ligase activity, forming carbon-carbon bonds
K1Y48_RS07270	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K1Y48_RS07280	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K1Y48_RS07290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K1Y48_RS07295	COG1181	Belongs to the D-alanine--D-alanine ligase family
K1Y48_RS07300	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K1Y48_RS07305	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K1Y48_RS07310	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K1Y48_RS07320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K1Y48_RS07325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K1Y48_RS07330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K1Y48_RS07350	COG0275	rRNA processing
K1Y48_RS07355	COG2001	Belongs to the MraZ family
K1Y48_RS07370	COG0617	tRNA 3'-terminal CCA addition
K1Y48_RS07375	COG1022	Amp-dependent synthetase and ligase
K1Y48_RS07380	COG0625	glutathione transferase activity
K1Y48_RS07385	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K1Y48_RS07395	COG0653	protein targeting
K1Y48_RS07400	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K1Y48_RS07405	COG0494	nUDIX hydrolase
K1Y48_RS07410	COG0463	Glycosyl transferase, family 2
K1Y48_RS07420	COG0438	transferase activity, transferring glycosyl groups
K1Y48_RS07440	COG0463	Glycosyl transferase, family 2
K1Y48_RS07455	COG1519	Transferase
K1Y48_RS07460	COG1560	Kdo2-lipid A biosynthetic process
K1Y48_RS07465	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K1Y48_RS07470	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K1Y48_RS07475	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K1Y48_RS07480	COG1040	competence protein
K1Y48_RS07485	COG0156	8-amino-7-oxononanoate synthase activity
K1Y48_RS07500	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K1Y48_RS07510	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K1Y48_RS07515	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K1Y48_RS07520	COG0390	transport system, permease component
K1Y48_RS07525	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K1Y48_RS07530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K1Y48_RS07530	COG0543	2 iron, 2 sulfur cluster binding
K1Y48_RS07550	COG1309	transcriptional regulator
K1Y48_RS07555	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K1Y48_RS07560	COG1566	PFAM secretion protein HlyD family protein
K1Y48_RS07570	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K1Y48_RS07575	COG1872	DUF167
K1Y48_RS07635	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K1Y48_RS07640	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K1Y48_RS07645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K1Y48_RS07660	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K1Y48_RS07675	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K1Y48_RS07680	COG0735	belongs to the Fur family
K1Y48_RS07685	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K1Y48_RS07690	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K1Y48_RS07695	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K1Y48_RS07700	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K1Y48_RS07705	COG0659	secondary active sulfate transmembrane transporter activity
K1Y48_RS07710	COG0288	reversible hydration of carbon dioxide
K1Y48_RS07715	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K1Y48_RS07720	COG2226	methyltransferase
K1Y48_RS07730	COG2813	Specifically methylates the guanine in position
K1Y48_RS07730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K1Y48_RS07735	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K1Y48_RS07745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K1Y48_RS07750	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K1Y48_RS07755	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K1Y48_RS07755	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K1Y48_RS07770	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K1Y48_RS07795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K1Y48_RS07820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K1Y48_RS07840	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K1Y48_RS07845	COG0081	regulation of translation
K1Y48_RS07850	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K1Y48_RS07855	COG0222	ribosome binding
K1Y48_RS07860	COG0085	RNA polymerase activity
K1Y48_RS07865	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K1Y48_RS07870	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K1Y48_RS07875	COG0049	tRNA binding
K1Y48_RS07880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K1Y48_RS07885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K1Y48_RS07890	COG0051	transcription antitermination factor activity, RNA binding
K1Y48_RS07895	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K1Y48_RS07900	COG0088	Forms part of the polypeptide exit tunnel
K1Y48_RS07905	COG0089	rRNA binding
K1Y48_RS07910	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K1Y48_RS07915	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K1Y48_RS07920	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K1Y48_RS07930	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K1Y48_RS07935	COG0255	Belongs to the universal ribosomal protein uL29 family
K1Y48_RS07940	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K1Y48_RS07945	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K1Y48_RS07950	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K1Y48_RS07955	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K1Y48_RS07960	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K1Y48_RS07965	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K1Y48_RS07970	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K1Y48_RS07975	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K1Y48_RS07980	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K1Y48_RS07985	COG1841	ribosomal large subunit assembly
K1Y48_RS07990	COG0200	Binds to the 23S rRNA
K1Y48_RS07995	COG0201	protein transport
K1Y48_RS08000	COG0563	adenylate kinase activity
K1Y48_RS08005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K1Y48_RS08010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K1Y48_RS08015	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K1Y48_RS08020	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K1Y48_RS08025	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K1Y48_RS08030	COG0202	RNA polymerase activity
K1Y48_RS08035	COG0203	ribosomal protein L17
K1Y48_RS08040	COG0756	dUTP diphosphatase activity
K1Y48_RS08045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K1Y48_RS08060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K1Y48_RS08075	COG0156	8-amino-7-oxononanoate synthase activity
K1Y48_RS08080	COG3321	synthase
K1Y48_RS08080	COG0604	alcohol dehydrogenase
K1Y48_RS08080	COG1028	Short-chain dehydrogenase reductase Sdr
K1Y48_RS08090	COG1596	polysaccharide export
K1Y48_RS08195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K1Y48_RS08205	COG4974	Belongs to the 'phage' integrase family
K1Y48_RS08210	COG0517	IMP dehydrogenase activity
K1Y48_RS08225	COG4974	Belongs to the 'phage' integrase family
K1Y48_RS08230	COG0517	IMP dehydrogenase activity
K1Y48_RS08275	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K1Y48_RS08315	COG1104	cysteine desulfurase activity
K1Y48_RS08350	COG2189	Belongs to the N(4) N(6)-methyltransferase family
K1Y48_RS08400	COG0671	phosphoesterase, PA-phosphatase related
K1Y48_RS08420	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K1Y48_RS08430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K1Y48_RS08435	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K1Y48_RS08435	COG0678	peroxiredoxin activity
K1Y48_RS08440	COG0560	Phosphoserine phosphatase
K1Y48_RS08445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K1Y48_RS08450	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K1Y48_RS08455	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K1Y48_RS08475	COG0492	ferredoxin-NADP+ reductase activity
K1Y48_RS08480	COG1674	ftsk spoiiie
K1Y48_RS08485	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K1Y48_RS08495	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K1Y48_RS08500	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K1Y48_RS08510	COG1376	ErfK ybiS ycfS ynhG family protein
K1Y48_RS08545	COG0779	Required for maturation of 30S ribosomal subunits
K1Y48_RS08550	COG0195	Participates in both transcription termination and antitermination
K1Y48_RS08550	COG2251	uridine kinase activity
K1Y48_RS08555	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K1Y48_RS08560	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K1Y48_RS08565	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K1Y48_RS08570	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K1Y48_RS08575	COG1185	polyribonucleotide nucleotidyltransferase activity
K1Y48_RS08580	COG0612	Peptidase, M16
K1Y48_RS08585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K1Y48_RS08595	COG0328	RNA-DNA hybrid ribonuclease activity
K1Y48_RS08610	COG0137	argininosuccinate synthase activity
K1Y48_RS08615	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K1Y48_RS08620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K1Y48_RS08625	COG0527	aspartate kinase activity
K1Y48_RS08640	COG2895	sulfate adenylyltransferase (ATP) activity
K1Y48_RS08650	COG0175	sulfate reduction
K1Y48_RS08655	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K1Y48_RS08660	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K1Y48_RS08675	COG1252	NADH dehydrogenase
K1Y48_RS08680	COG1573	uracil-dna glycosylase
K1Y48_RS08685	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K1Y48_RS08690	COG0542	response to heat
K1Y48_RS08695	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K1Y48_RS08700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K1Y48_RS08705	COG0693	protein deglycase activity
K1Y48_RS08710	COG0793	Belongs to the peptidase S41A family
K1Y48_RS08720	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K1Y48_RS08725	COG0058	SHG alpha-glucan phosphorylase activity
K1Y48_RS08735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K1Y48_RS08740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K1Y48_RS08750	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K1Y48_RS08755	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K1Y48_RS08770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K1Y48_RS08785	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K1Y48_RS08790	COG2154	pterin-4-alpha-carbinolamine dehydratase
K1Y48_RS08815	COG0204	Acyl-transferase
K1Y48_RS08820	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K1Y48_RS08825	COG0751	glycine-tRNA ligase activity
K1Y48_RS08870	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K1Y48_RS08875	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K1Y48_RS08880	COG0321	lipoyl(octanoyl) transferase activity
K1Y48_RS08890	COG1686	Belongs to the peptidase S11 family
K1Y48_RS08895	COG0772	Belongs to the SEDS family
K1Y48_RS08910	COG1792	Involved in formation and maintenance of cell shape
K1Y48_RS08915	COG1077	Cell shape determining protein MreB Mrl
K1Y48_RS08920	COG0737	Belongs to the 5'-nucleotidase family
K1Y48_RS08925	COG3439	Domain of unknown function DUF302
K1Y48_RS08940	COG2204	response regulator
K1Y48_RS08945	COG3852	Histidine kinase
K1Y48_RS08955	COG0315	cyclic pyranopterin monophosphate synthase activity
K1Y48_RS08965	COG0243	molybdopterin cofactor binding
K1Y48_RS08970	COG0437	4 iron, 4 sulfur cluster binding
K1Y48_RS08980	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K1Y48_RS08985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K1Y48_RS08990	COG0425	Belongs to the sulfur carrier protein TusA family
K1Y48_RS08995	COG2210	Belongs to the sulfur carrier protein TusA family
K1Y48_RS09025	COG2048	Heterodisulfide reductase, subunit B
K1Y48_RS09030	COG0509	glycine decarboxylation via glycine cleavage system
K1Y48_RS09040	COG0509	glycine decarboxylation via glycine cleavage system
K1Y48_RS09050	COG0095	Lipoate-protein ligase
K1Y48_RS09055	COG0644	oxidoreductase
K1Y48_RS09105	COG0123	including yeast histone deacetylase and acetoin utilization protein
K1Y48_RS09120	COG0583	DNA-binding transcription factor activity
K1Y48_RS09135	COG0586	Pfam SNARE associated Golgi protein
K1Y48_RS09140	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K1Y48_RS09155	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K1Y48_RS09175	COG0791	NLP P60 protein
K1Y48_RS09175	COG1388	LysM domain
K1Y48_RS09185	COG1199	ATP-dependent helicase activity
K1Y48_RS09215	COG2960	long-chain fatty acid transporting porin activity
K1Y48_RS09220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K1Y48_RS09225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K1Y48_RS09230	COG0084	hydrolase, TatD family'
K1Y48_RS09235	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K1Y48_RS09250	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K1Y48_RS09260	COG0640	Transcriptional regulator
K1Y48_RS09270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K1Y48_RS09285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K1Y48_RS09290	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K1Y48_RS09300	COG0860	N-Acetylmuramoyl-L-alanine amidase
K1Y48_RS09305	COG1272	protein, Hemolysin III
K1Y48_RS09315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K1Y48_RS09325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K1Y48_RS09330	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K1Y48_RS09335	COG0047	phosphoribosylformylglycinamidine synthase activity
K1Y48_RS09335	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K1Y48_RS09385	COG1686	Belongs to the peptidase S11 family
K1Y48_RS09390	COG2814	Major facilitator Superfamily
K1Y48_RS09405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K1Y48_RS09420	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K1Y48_RS09430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K1Y48_RS09435	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K1Y48_RS09445	COG1193	negative regulation of DNA recombination
K1Y48_RS09490	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K1Y48_RS09495	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K1Y48_RS09505	COG0243	molybdopterin cofactor binding
K1Y48_RS09535	COG0529	Catalyzes the synthesis of activated sulfate
K1Y48_RS09535	COG2046	Belongs to the sulfate adenylyltransferase family
K1Y48_RS09540	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K1Y48_RS09560	COG4319	ketosteroid isomerase
K1Y48_RS09580	COG0459	protein refolding
K1Y48_RS09585	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K1Y48_RS09595	COG4232	protein-disulfide reductase activity
K1Y48_RS09610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K1Y48_RS09620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K1Y48_RS09630	COG4178	(ABC) transporter
K1Y48_RS09650	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K1Y48_RS09655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K1Y48_RS09660	COG0196	riboflavin kinase activity
K1Y48_RS09670	COG1538	Outer membrane efflux protein
K1Y48_RS09835	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K1Y48_RS09835	COG0446	pyridine nucleotide-disulphide oxidoreductase
K1Y48_RS09845	COG0174	glutamine synthetase
K1Y48_RS09850	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K1Y48_RS09860	COG0069	glutamate synthase activity
K1Y48_RS09865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K1Y48_RS09870	COG0515	serine threonine protein kinase
K1Y48_RS09870	COG2815	serine threonine protein kinase
K1Y48_RS09885	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K1Y48_RS09915	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K1Y48_RS09920	COG0493	'glutamate synthase
K1Y48_RS09925	COG0069	glutamate synthase activity
K1Y48_RS09925	COG0070	glutamate synthase
K1Y48_RS09925	COG0067	glutamate synthase
K1Y48_RS09930	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K1Y48_RS09935	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K1Y48_RS09940	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K1Y48_RS09945	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K1Y48_RS09980	COG0432	Pfam Uncharacterised protein family UPF0047
K1Y48_RS09990	COG1193	negative regulation of DNA recombination
K1Y48_RS09995	COG0028	Belongs to the TPP enzyme family
K1Y48_RS10005	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K1Y48_RS10010	COG0688	phosphatidylethanolamine metabolic process
K1Y48_RS10015	COG1183	phosphatidylcholine synthase activity
K1Y48_RS10025	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K1Y48_RS10100	COG0642	Histidine kinase
K1Y48_RS10115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K1Y48_RS10125	COG0187	DNA topoisomerase II activity
K1Y48_RS10135	COG0741	lytic transglycosylase activity
K1Y48_RS10140	COG1741	Belongs to the pirin family
K1Y48_RS10145	COG3707	response regulator
K1Y48_RS10155	COG1648	precorrin-2 dehydrogenase activity
K1Y48_RS10155	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K1Y48_RS10160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K1Y48_RS10165	COG0243	molybdopterin cofactor binding
K1Y48_RS10170	COG2146	nitrite reductase [NAD(P)H] activity
K1Y48_RS10175	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K1Y48_RS10185	COG2223	nitrite transmembrane transporter activity
K1Y48_RS10190	COG1116	anion transmembrane transporter activity
K1Y48_RS10190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K1Y48_RS10200	COG3189	MarR family transcriptional regulator
K1Y48_RS10205	COG0509	glycine decarboxylation via glycine cleavage system
K1Y48_RS10225	COG1017	nitric oxide dioxygenase activity
K1Y48_RS10225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K1Y48_RS10275	COG0670	Belongs to the BI1 family
K1Y48_RS10290	COG1193	negative regulation of DNA recombination
K1Y48_RS10295	COG0277	FAD linked oxidase domain protein
K1Y48_RS10300	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K1Y48_RS10305	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K1Y48_RS10310	COG1428	Deoxynucleoside kinase
K1Y48_RS10315	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K1Y48_RS10320	COG0617	tRNA 3'-terminal CCA addition
K1Y48_RS10320	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K1Y48_RS10320	COG3620	sequence-specific DNA binding
K1Y48_RS10330	COG0463	Glycosyl transferase, family 2
K1Y48_RS10340	COG0519	Catalyzes the synthesis of GMP from XMP
K1Y48_RS10355	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K1Y48_RS10360	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K1Y48_RS10360	COG3264	Mechanosensitive ion channel
K1Y48_RS10380	COG0009	L-threonylcarbamoyladenylate synthase
K1Y48_RS10385	COG1994	Peptidase M50
K1Y48_RS10390	COG0180	Tryptophanyl-tRNA synthetase
K1Y48_RS10395	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K1Y48_RS10400	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K1Y48_RS10425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K1Y48_RS10440	COG1105	Belongs to the carbohydrate kinase PfkB family
K1Y48_RS10445	COG0280	phosphate acetyltransferase
K1Y48_RS10450	COG0477	Major facilitator Superfamily
K1Y48_RS10455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K1Y48_RS10460	COG0508	dehydrogenase complex catalyzes the overall conversion of
K1Y48_RS10465	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K1Y48_RS10470	COG0574	Belongs to the PEP-utilizing enzyme family
K1Y48_RS10470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K1Y48_RS10490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K1Y48_RS10495	COG2171	N-acyltransferase activity
K1Y48_RS10515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K1Y48_RS10520	COG0402	S-adenosylhomocysteine deaminase activity
K1Y48_RS10530	COG1388	LysM domain
K1Y48_RS10530	COG0791	NLP P60 protein
K1Y48_RS10555	COG2814	Major facilitator Superfamily
K1Y48_RS10560	COG0038	chloride channel
K1Y48_RS10570	COG0583	DNA-binding transcription factor activity
K1Y48_RS10575	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K1Y48_RS10585	COG2363	Small membrane protein
K1Y48_RS10610	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K1Y48_RS10615	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K1Y48_RS10645	COG0109	protoheme IX farnesyltransferase activity
K1Y48_RS10650	COG2814	Major facilitator Superfamily
K1Y48_RS10665	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
K1Y48_RS10690	COG1333	cytochrome c biogenesis protein
K1Y48_RS10695	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K1Y48_RS10730	COG2915	High frequency lysogenization protein hflD homolog
K1Y48_RS10735	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K1Y48_RS10740	COG0024	Methionine aminopeptidase
K1Y48_RS10745	COG1489	DNA binding
K1Y48_RS10750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K1Y48_RS10760	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K1Y48_RS10765	COG1546	Belongs to the CinA family
K1Y48_RS10765	COG1058	Belongs to the CinA family
K1Y48_RS10770	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K1Y48_RS10775	COG2137	regulation of response to DNA damage stimulus
K1Y48_RS10795	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K1Y48_RS10810	COG0488	(ABC) transporter
K1Y48_RS10815	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K1Y48_RS10820	COG2204	response regulator
K1Y48_RS10835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K1Y48_RS10850	COG3416	Protein conserved in bacteria
K1Y48_RS10850	COG2943	transferase activity, transferring hexosyl groups
K1Y48_RS10865	COG2363	Small membrane protein
K1Y48_RS10875	COG0616	signal peptide processing
K1Y48_RS10880	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K1Y48_RS10885	COG0314	molybdopterin synthase activity
K1Y48_RS10890	COG1666	GTP binding
K1Y48_RS10905	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K1Y48_RS10910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K1Y48_RS10915	COG0714	Associated with various cellular activities
K1Y48_RS10930	COG1132	(ABC) transporter
K1Y48_RS10935	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K1Y48_RS10940	COG0450	alkyl hydroperoxide reductase
K1Y48_RS10950	COG0613	PHP domain protein
K1Y48_RS10955	COG0628	permease
K1Y48_RS10975	COG0084	hydrolase, TatD family'
K1Y48_RS10980	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K1Y48_RS10980	COG0321	lipoyl(octanoyl) transferase activity
K1Y48_RS11010	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K1Y48_RS11025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K1Y48_RS11030	COG0481	GTPase activity
K1Y48_RS11035	COG0681	Belongs to the peptidase S26 family
K1Y48_RS11045	COG0571	ribonuclease III activity
K1Y48_RS11050	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K1Y48_RS11055	COG1381	Involved in DNA repair and RecF pathway recombination
K1Y48_RS11060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K1Y48_RS11065	COG0736	holo-[acyl-carrier-protein] synthase activity
K1Y48_RS11075	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K1Y48_RS11075	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K1Y48_RS11080	COG0037	tRNA processing
K1Y48_RS11100	COG4454	pyrroloquinoline quinone binding
K1Y48_RS11125	COG0729	surface antigen
K1Y48_RS11130	COG2911	Protein conserved in bacteria
K1Y48_RS11185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K1Y48_RS11195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K1Y48_RS11200	COG0438	transferase activity, transferring glycosyl groups
K1Y48_RS11215	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K1Y48_RS11220	COG1469	GTP cyclohydrolase I activity
K1Y48_RS11225	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K1Y48_RS11230	COG0142	geranyltranstransferase activity
K1Y48_RS11235	COG1722	exodeoxyribonuclease VII activity
K1Y48_RS11240	COG2223	nitrite transmembrane transporter activity
K1Y48_RS11250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K1Y48_RS11255	COG1570	exodeoxyribonuclease VII activity
K1Y48_RS11265	COG0531	amino acid
K1Y48_RS11275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K1Y48_RS11280	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K1Y48_RS11285	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K1Y48_RS11300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K1Y48_RS11315	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K1Y48_RS11320	COG0456	acetyltransferase
K1Y48_RS11335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K1Y48_RS11345	COG0438	transferase activity, transferring glycosyl groups
K1Y48_RS11350	COG0438	transferase activity, transferring glycosyl groups
K1Y48_RS11375	COG1012	belongs to the aldehyde dehydrogenase family
K1Y48_RS11400	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K1Y48_RS11410	COG5554	nitrogen fixation
K1Y48_RS11415	COG1104	cysteine desulfurase activity
K1Y48_RS11450	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K1Y48_RS11485	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
K1Y48_RS11490	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
K1Y48_RS11495	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
K1Y48_RS11500	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
K1Y48_RS11505	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
K1Y48_RS11520	COG5420	small protein containing a coiled-coil domain
K1Y48_RS11550	COG1566	PFAM secretion protein HlyD family protein
K1Y48_RS11645	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K1Y48_RS11690	COG1166	arginine decarboxylase activity
K1Y48_RS11695	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K1Y48_RS11700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K1Y48_RS11725	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K1Y48_RS11735	COG1196	nuclear chromosome segregation
K1Y48_RS11740	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K1Y48_RS11770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K1Y48_RS11775	COG0191	fructose-bisphosphate aldolase activity
K1Y48_RS11795	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
K1Y48_RS11800	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
K1Y48_RS11840	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K1Y48_RS11845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K1Y48_RS11860	COG0784	Response regulator, receiver
K1Y48_RS11860	COG2198	Histidine kinase
K1Y48_RS11860	COG2205	protein histidine kinase activity
K1Y48_RS11865	COG1024	Enoyl-CoA hydratase
K1Y48_RS11965	COG1215	transferase activity, transferring glycosyl groups
K1Y48_RS11985	COG4453	Protein conserved in bacteria
K1Y48_RS11995	COG3609	addiction module antidote protein, CC2985 family
K1Y48_RS12010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K1Y48_RS12070	COG1160	GTP binding
K1Y48_RS12075	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K1Y48_RS12085	COG0124	histidyl-tRNA synthetase
K1Y48_RS12090	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K1Y48_RS12105	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K1Y48_RS12110	COG0105	UTP biosynthetic process
K1Y48_RS12115	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K1Y48_RS12120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K1Y48_RS12125	COG0802	atpase or kinase
K1Y48_RS12135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K1Y48_RS12140	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K1Y48_RS12140	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K1Y48_RS12145	COG0004	ammonium transporteR
K1Y48_RS12150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K1Y48_RS12155	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K1Y48_RS12185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K1Y48_RS12190	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K1Y48_RS12200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K1Y48_RS12205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K1Y48_RS12215	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K1Y48_RS12220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K1Y48_RS12225	COG0416	fatty acid biosynthetic process
K1Y48_RS12230	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K1Y48_RS12240	COG1295	ribonuclease BN
K1Y48_RS12240	COG1959	2 iron, 2 sulfur cluster binding
K1Y48_RS12245	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K1Y48_RS12250	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K1Y48_RS12260	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K1Y48_RS12265	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K1Y48_RS12270	COG1058	Belongs to the CinA family
K1Y48_RS12270	COG1546	Belongs to the CinA family
K1Y48_RS12275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K1Y48_RS12305	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K1Y48_RS12315	COG0330	HflC and HflK could
K1Y48_RS12320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K1Y48_RS12325	COG1923	regulation of RNA biosynthetic process
K1Y48_RS12330	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K1Y48_RS12335	COG0424	maF-like protein
K1Y48_RS12350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K1Y48_RS12355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K1Y48_RS12360	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K1Y48_RS12375	COG3025	triphosphatase activity
K1Y48_RS12385	COG0308	aminopeptidase N
K1Y48_RS12395	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K1Y48_RS12405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K1Y48_RS12425	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K1Y48_RS12430	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K1Y48_RS12435	COG0740	serine-type endopeptidase activity
K1Y48_RS12440	COG0544	peptidyl-prolyl cis-trans isomerase activity
K1Y48_RS12445	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K1Y48_RS12450	COG0284	orotidine-5'-phosphate decarboxylase activity
K1Y48_RS12455	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K1Y48_RS12460	COG0776	regulation of translation
K1Y48_RS12470	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K1Y48_RS12475	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K1Y48_RS12480	COG0287	Prephenate dehydrogenase
K1Y48_RS12485	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K1Y48_RS12490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K1Y48_RS12500	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K1Y48_RS12510	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K1Y48_RS12515	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K1Y48_RS12560	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K1Y48_RS12570	COG1215	transferase activity, transferring glycosyl groups
K1Y48_RS12575	COG1215	transferase activity, transferring glycosyl groups
K1Y48_RS12680	COG0582	viral genome integration into host DNA