locus-tag	class	description
ACIFE_RS00015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACIFE_RS00020	COG0592	DNA-directed DNA polymerase activity
ACIFE_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ACIFE_RS00030	COG0187	DNA topoisomerase II activity
ACIFE_RS00040	COG0493	'glutamate synthase
ACIFE_RS00040	COG0543	2 iron, 2 sulfur cluster binding
ACIFE_RS00045	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ACIFE_RS00050	COG2894	cell division
ACIFE_RS00055	COG0850	regulation of cytokinetic process
ACIFE_RS00070	COG2922	Belongs to the Smg family
ACIFE_RS00075	COG0758	DNA mediated transformation
ACIFE_RS00080	COG1388	LysM domain
ACIFE_RS00080	COG1705	Flagellar rod assembly protein muramidase FlgJ
ACIFE_RS00085	COG0242	peptide deformylase activity
ACIFE_RS00090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACIFE_RS00095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ACIFE_RS00105	COG5000	phosphorelay sensor kinase activity
ACIFE_RS00110	COG2204	response regulator
ACIFE_RS00120	COG0840	transmembrane signaling receptor activity
ACIFE_RS00125	COG3459	Glycosyltransferase 36 associated
ACIFE_RS00140	COG1393	Belongs to the ArsC family
ACIFE_RS00160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACIFE_RS00165	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ACIFE_RS00170	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ACIFE_RS00175	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACIFE_RS00180	COG2833	Protein of unknown function (DUF455)
ACIFE_RS00185	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACIFE_RS00190	COG2161	toxin-antitoxin pair type II binding
ACIFE_RS00195	COG4115	mRNA cleavage
ACIFE_RS00245	COG2816	NAD+ diphosphatase activity
ACIFE_RS00250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACIFE_RS00280	COG1914	H( )-stimulated, divalent metal cation uptake system
ACIFE_RS00285	COG1842	Phage shock protein A
ACIFE_RS00290	COG0393	Putative heavy-metal-binding
ACIFE_RS00310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACIFE_RS00315	COG4521	taurine ABC transporter
ACIFE_RS00320	COG0543	2 iron, 2 sulfur cluster binding
ACIFE_RS00320	COG0493	'glutamate synthase
ACIFE_RS00340	COG2188	Transcriptional regulator
ACIFE_RS00355	COG0583	DNA-binding transcription factor activity
ACIFE_RS00375	COG0277	FAD linked oxidase domain protein
ACIFE_RS00380	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ACIFE_RS00385	COG0792	nuclease activity
ACIFE_RS00390	COG3107	peptidoglycan biosynthetic process
ACIFE_RS00405	COG1858	cytochrome C peroxidase
ACIFE_RS00410	COG1333	cytochrome c biogenesis protein
ACIFE_RS00415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACIFE_RS00420	COG1278	Cold shock
ACIFE_RS00435	COG1530	ribonuclease E activity
ACIFE_RS00440	COG0424	maF-like protein
ACIFE_RS00455	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ACIFE_RS00465	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ACIFE_RS00475	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACIFE_RS00490	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ACIFE_RS00505	COG0811	peptide transport
ACIFE_RS00530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ACIFE_RS00535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ACIFE_RS00540	COG1074	ATP-dependent DNA helicase activity
ACIFE_RS00545	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ACIFE_RS00555	COG3220	belongs to the UPF0276 family
ACIFE_RS00565	COG1560	Kdo2-lipid A biosynthetic process
ACIFE_RS00580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACIFE_RS00590	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACIFE_RS00635	COG2885	chlorophyll binding
ACIFE_RS00645	COG0602	queuosine metabolic process
ACIFE_RS00650	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ACIFE_RS00655	COG0823	Involved in the tonB-independent uptake of proteins
ACIFE_RS00670	COG0811	peptide transport
ACIFE_RS00675	COG0824	Thioesterase
ACIFE_RS00680	COG2255	four-way junction helicase activity
ACIFE_RS00685	COG0632	four-way junction helicase activity
ACIFE_RS00690	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ACIFE_RS00695	COG0217	transcriptional regulatory protein
ACIFE_RS00705	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ACIFE_RS00710	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACIFE_RS00720	COG2095	MarC family integral membrane protein
ACIFE_RS00730	COG0488	(ABC) transporter
ACIFE_RS00735	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ACIFE_RS00745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ACIFE_RS00750	COG0706	membrane insertase activity
ACIFE_RS00755	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ACIFE_RS00780	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ACIFE_RS00820	COG1131	(ABC) transporter
ACIFE_RS00825	COG2945	thiolester hydrolase activity
ACIFE_RS00840	COG1959	2 iron, 2 sulfur cluster binding
ACIFE_RS00850	COG0134	indole-3-glycerol-phosphate synthase activity
ACIFE_RS00855	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACIFE_RS00885	COG0546	phosphoglycolate phosphatase activity
ACIFE_RS00890	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ACIFE_RS00900	COG0469	pyruvate kinase activity
ACIFE_RS00905	COG0126	phosphoglycerate kinase activity
ACIFE_RS00910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACIFE_RS00915	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ACIFE_RS00920	COG1494	fructose-1,6-bisphosphatase
ACIFE_RS00925	COG0483	inositol monophosphate 1-phosphatase activity
ACIFE_RS00935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ACIFE_RS00940	COG0598	Magnesium transport protein CorA
ACIFE_RS00945	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACIFE_RS00950	COG1322	Protein conserved in bacteria
ACIFE_RS00955	COG1970	mechanosensitive ion channel activity
ACIFE_RS00970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIFE_RS01010	COG1671	Belongs to the UPF0178 family
ACIFE_RS01045	COG0697	spore germination
ACIFE_RS01070	COG0165	Argininosuccinate lyase
ACIFE_RS01085	COG0166	Belongs to the GPI family
ACIFE_RS01090	COG1686	Belongs to the peptidase S11 family
ACIFE_RS01095	COG0625	glutathione transferase activity
ACIFE_RS01100	COG0655	NAD(P)H dehydrogenase (quinone) activity
ACIFE_RS01105	COG1733	regulation of RNA biosynthetic process
ACIFE_RS01110	COG2353	YceI-like domain
ACIFE_RS01120	COG2217	Heavy metal translocating P-type atpase
ACIFE_RS01135	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACIFE_RS01160	COG0519	Catalyzes the synthesis of GMP from XMP
ACIFE_RS01160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACIFE_RS01170	COG0004	ammonium transporteR
ACIFE_RS01185	COG0004	ammonium transporteR
ACIFE_RS01190	COG0347	Belongs to the P(II) protein family
ACIFE_RS01200	COG2719	SpoVR family
ACIFE_RS01205	COG2718	Belongs to the UPF0229 family
ACIFE_RS01210	COG0004	ammonium transporteR
ACIFE_RS01215	COG2766	serine protein kinase
ACIFE_RS01235	COG2308	Evidence 4 Homologs of previously reported genes of
ACIFE_RS01245	COG3852	Histidine kinase
ACIFE_RS01260	COG0142	geranyltranstransferase activity
ACIFE_RS01295	COG0488	(ABC) transporter
ACIFE_RS01305	COG1573	uracil-dna glycosylase
ACIFE_RS01395	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ACIFE_RS01400	COG0228	four-way junction DNA binding
ACIFE_RS01410	COG0336	Belongs to the RNA methyltransferase TrmD family
ACIFE_RS01415	COG0335	large ribosomal subunit rRNA binding
ACIFE_RS01430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACIFE_RS01435	COG3118	belongs to the thioredoxin family
ACIFE_RS01450	COG0629	single-stranded DNA binding
ACIFE_RS01455	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ACIFE_RS01480	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ACIFE_RS01490	COG2733	membrane
ACIFE_RS01495	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ACIFE_RS01500	COG1940	carbohydrate kinase activity
ACIFE_RS01505	COG1449	Belongs to the glycosyl hydrolase 57 family
ACIFE_RS01515	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ACIFE_RS01520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ACIFE_RS01535	COG0363	glucosamine-6-phosphate deaminase activity
ACIFE_RS01560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACIFE_RS01570	COG0531	amino acid
ACIFE_RS01575	COG1472	Belongs to the glycosyl hydrolase 3 family
ACIFE_RS01580	COG0360	Binds together with S18 to 16S ribosomal RNA
ACIFE_RS01595	COG0359	binds to the 23S rRNA
ACIFE_RS01600	COG0305	Participates in initiation and elongation during chromosome replication
ACIFE_RS01605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACIFE_RS01620	COG0006	proline dipeptidase activity
ACIFE_RS01635	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ACIFE_RS01695	COG4974	Belongs to the 'phage' integrase family
ACIFE_RS01720	COG4221	oxidoreductase activity
ACIFE_RS01730	COG0776	regulation of translation
ACIFE_RS01755	COG1205	dead DEAH box helicase
ACIFE_RS01755	COG1111	helicase
ACIFE_RS01760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ACIFE_RS01955	COG2944	sequence-specific DNA binding
ACIFE_RS01990	COG1484	DNA-dependent DNA replication
ACIFE_RS02100	COG0583	DNA-binding transcription factor activity
ACIFE_RS02105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACIFE_RS02110	COG3002	Belongs to the UPF0753 family
ACIFE_RS02125	COG0418	dihydroorotase activity
ACIFE_RS02135	COG1846	Transcriptional regulator
ACIFE_RS02145	COG2353	YceI-like domain
ACIFE_RS02220	COG4454	pyrroloquinoline quinone binding
ACIFE_RS02290	COG1285	pathogenesis
ACIFE_RS02295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACIFE_RS02315	COG1104	cysteine desulfurase activity
ACIFE_RS02350	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACIFE_RS02445	COG4717	serine-type aminopeptidase activity
ACIFE_RS02450	COG0420	3'-5' exonuclease activity
ACIFE_RS02460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ACIFE_RS02575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACIFE_RS02585	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACIFE_RS02590	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ACIFE_RS02600	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ACIFE_RS02605	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACIFE_RS02610	COG2890	protein-(glutamine-N5) methyltransferase activity
ACIFE_RS02615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACIFE_RS02620	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ACIFE_RS02625	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACIFE_RS02630	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACIFE_RS02635	COG0742	ribosomal rna small subunit methyltransferase
ACIFE_RS02640	COG0552	protein localization to endoplasmic reticulum
ACIFE_RS02645	COG2884	Cell division ATP-binding protein ftsE
ACIFE_RS02650	COG2177	Part of the ABC transporter FtsEX involved in
ACIFE_RS02665	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ACIFE_RS02670	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ACIFE_RS02675	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ACIFE_RS02685	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ACIFE_RS02705	COG2226	methyltransferase
ACIFE_RS02710	COG2967	ApaG domain
ACIFE_RS02715	COG1534	Rna-binding protein
ACIFE_RS02720	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ACIFE_RS02735	COG1151	hydroxylamine reductase activity
ACIFE_RS02740	COG0633	Ferredoxin
ACIFE_RS02740	COG0543	2 iron, 2 sulfur cluster binding
ACIFE_RS02750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ACIFE_RS02760	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ACIFE_RS02765	COG0297	glycogen (starch) synthase activity
ACIFE_RS02790	COG0114	fumarate hydratase activity
ACIFE_RS02795	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ACIFE_RS02800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACIFE_RS02800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACIFE_RS02805	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ACIFE_RS02810	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACIFE_RS02815	COG1420	regulation of RNA biosynthetic process
ACIFE_RS02820	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACIFE_RS02825	COG0443	Heat shock 70 kDa protein
ACIFE_RS02830	COG0484	heat shock protein binding
ACIFE_RS02835	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ACIFE_RS02845	COG0489	protein tyrosine kinase activity
ACIFE_RS02850	COG0717	Belongs to the dCTP deaminase family
ACIFE_RS02870	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ACIFE_RS02890	COG0366	Alpha amylase catalytic
ACIFE_RS02900	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ACIFE_RS02905	COG1640	4-alpha-glucanotransferase
ACIFE_RS02925	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ACIFE_RS02930	COG1028	Short-chain dehydrogenase reductase Sdr
ACIFE_RS02935	COG2863	cytochrome
ACIFE_RS02950	COG0583	DNA-binding transcription factor activity
ACIFE_RS02955	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACIFE_RS02965	COG1388	LysM domain
ACIFE_RS02965	COG0741	lytic transglycosylase activity
ACIFE_RS02970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACIFE_RS02975	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ACIFE_RS02980	COG0538	isocitrate dehydrogenase activity
ACIFE_RS02985	COG0045	succinate-CoA ligase (ADP-forming) activity
ACIFE_RS02995	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ACIFE_RS03000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACIFE_RS03000	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACIFE_RS03005	COG0347	Belongs to the P(II) protein family
ACIFE_RS03025	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ACIFE_RS03030	COG1850	ribulose-bisphosphate carboxylase activity
ACIFE_RS03035	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ACIFE_RS03040	COG0235	Class ii aldolase
ACIFE_RS03050	COG0242	peptide deformylase activity
ACIFE_RS03055	COG0811	peptide transport
ACIFE_RS03060	COG0848	biopolymer transport protein
ACIFE_RS03075	COG0402	S-adenosylhomocysteine deaminase activity
ACIFE_RS03080	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACIFE_RS03090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACIFE_RS03115	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ACIFE_RS03115	COG3608	succinylglutamate desuccinylase aspartoacylase
ACIFE_RS03135	COG0746	molybdenum cofactor guanylyltransferase activity
ACIFE_RS03145	COG0583	DNA-binding transcription factor activity
ACIFE_RS03160	COG0295	cytidine deaminase activity
ACIFE_RS03190	COG0732	type I restriction modification DNA specificity domain
ACIFE_RS03215	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ACIFE_RS03240	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ACIFE_RS03250	COG2204	response regulator
ACIFE_RS03260	COG2205	protein histidine kinase activity
ACIFE_RS03265	COG0497	DNA recombination
ACIFE_RS03270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACIFE_RS03275	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ACIFE_RS03280	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ACIFE_RS03280	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ACIFE_RS03285	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ACIFE_RS03315	COG2217	Heavy metal translocating P-type atpase
ACIFE_RS03320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ACIFE_RS03355	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ACIFE_RS03360	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ACIFE_RS03365	COG3791	Glutathione-dependent formaldehyde-activating
ACIFE_RS03370	COG3284	Transcriptional regulator
ACIFE_RS03420	COG3550	peptidyl-serine autophosphorylation
ACIFE_RS03440	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACIFE_RS03460	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ACIFE_RS03490	COG0347	Belongs to the P(II) protein family
ACIFE_RS03535	COG5290	Psort location Cytoplasmic, score
ACIFE_RS03555	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ACIFE_RS03560	COG0776	regulation of translation
ACIFE_RS03570	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ACIFE_RS03585	COG4232	protein-disulfide reductase activity
ACIFE_RS03595	COG1595	DNA-templated transcription, initiation
ACIFE_RS03630	COG3220	belongs to the UPF0276 family
ACIFE_RS03700	COG0588	phosphoglycerate mutase activity
ACIFE_RS03705	COG0166	Belongs to the GPI family
ACIFE_RS03710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACIFE_RS03715	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ACIFE_RS03735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACIFE_RS03740	COG0148	phosphopyruvate hydratase activity
ACIFE_RS03760	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ACIFE_RS03770	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACIFE_RS03770	COG0022	dehydrogenase e1 component
ACIFE_RS03775	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ACIFE_RS03785	COG2326	polyphosphate kinase activity
ACIFE_RS03790	COG0126	phosphoglycerate kinase activity
ACIFE_RS03795	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACIFE_RS03800	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ACIFE_RS03825	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACIFE_RS03860	COG1484	DNA-dependent DNA replication
ACIFE_RS03890	COG3328	transposase activity
ACIFE_RS03915	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ACIFE_RS03930	COG0732	type I restriction modification DNA specificity domain
ACIFE_RS03935	COG3609	addiction module antidote protein, CC2985 family
ACIFE_RS03940	COG3668	Plasmid stabilization system
ACIFE_RS03945	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
ACIFE_RS03965	COG1466	dna polymerase III delta subunit
ACIFE_RS03975	COG0495	leucyl-tRNA aminoacylation
ACIFE_RS03985	COG2161	toxin-antitoxin pair type II binding
ACIFE_RS04005	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ACIFE_RS04010	COG0659	secondary active sulfate transmembrane transporter activity
ACIFE_RS04015	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACIFE_RS04040	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ACIFE_RS04055	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ACIFE_RS04060	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ACIFE_RS04075	COG0436	Aminotransferase
ACIFE_RS04085	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACIFE_RS04120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ACIFE_RS04135	COG2336	PFAM SpoVT AbrB
ACIFE_RS04145	COG1002	Type II restriction enzyme, methylase subunits
ACIFE_RS04150	COG4804	nuclease activity
ACIFE_RS04155	COG1061	Type III restriction enzyme res subunit
ACIFE_RS04160	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ACIFE_RS04170	COG1104	cysteine desulfurase activity
ACIFE_RS04210	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACIFE_RS04340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ACIFE_RS04350	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACIFE_RS04355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACIFE_RS04365	COG1136	(ABC) transporter
ACIFE_RS04375	COG0658	competence protein
ACIFE_RS04375	COG2333	competence protein COMEC
ACIFE_RS04380	COG0811	peptide transport
ACIFE_RS04385	COG0848	biopolymer transport protein
ACIFE_RS04400	COG1663	tetraacyldisaccharide 4'-kinase activity
ACIFE_RS04405	COG2835	tetraacyldisaccharide 4'-kinase activity
ACIFE_RS04410	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ACIFE_RS04470	COG3344	reverse transcriptase
ACIFE_RS04490	COG4453	Protein conserved in bacteria
ACIFE_RS04500	COG1573	uracil-dna glycosylase
ACIFE_RS04505	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ACIFE_RS04510	COG0542	response to heat
ACIFE_RS04515	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ACIFE_RS04520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACIFE_RS04530	COG0793	Belongs to the peptidase S41A family
ACIFE_RS04540	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ACIFE_RS04545	COG0058	SHG alpha-glucan phosphorylase activity
ACIFE_RS04555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACIFE_RS04560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACIFE_RS04570	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ACIFE_RS04580	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ACIFE_RS04610	COG1278	Cold shock
ACIFE_RS04615	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ACIFE_RS04620	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ACIFE_RS04630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACIFE_RS04640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACIFE_RS04645	COG1702	phosphate starvation-inducible protein PhoH
ACIFE_RS04655	COG4535	Mg2 and Co2 transporter CorC
ACIFE_RS04660	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ACIFE_RS04665	COG0312	modulator of DNA gyrase
ACIFE_RS04675	COG1121	(ABC) transporter
ACIFE_RS04685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACIFE_RS04725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACIFE_RS04730	COG0438	transferase activity, transferring glycosyl groups
ACIFE_RS04735	COG0438	transferase activity, transferring glycosyl groups
ACIFE_RS04740	COG1132	(ABC) transporter
ACIFE_RS04745	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ACIFE_RS04770	COG2226	methyltransferase
ACIFE_RS04775	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ACIFE_RS04780	COG0066	3-isopropylmalate dehydratase activity
ACIFE_RS04790	COG0259	pyridoxamine-phosphate oxidase activity
ACIFE_RS04795	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ACIFE_RS04810	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ACIFE_RS04830	COG0109	protoheme IX farnesyltransferase activity
ACIFE_RS04840	COG1968	undecaprenyl-diphosphatase activity
ACIFE_RS04845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACIFE_RS04855	COG0505	Belongs to the CarA family
ACIFE_RS04875	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACIFE_RS04880	COG1845	cytochrome c oxidase, subunit III
ACIFE_RS04945	COG1131	(ABC) transporter
ACIFE_RS04955	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ACIFE_RS05000	COG0033	Phosphoglucomutase
ACIFE_RS05020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIFE_RS05025	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ACIFE_RS05055	COG0811	peptide transport
ACIFE_RS05080	COG0167	dihydroorotate dehydrogenase activity
ACIFE_RS05085	COG0408	coproporphyrinogen oxidase activity
ACIFE_RS05090	COG0009	L-threonylcarbamoyladenylate synthase
ACIFE_RS05095	COG0151	Belongs to the GarS family
ACIFE_RS05100	COG0138	bifunctional purine biosynthesis protein purh
ACIFE_RS05115	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ACIFE_RS05120	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ACIFE_RS05125	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ACIFE_RS05135	COG2205	protein histidine kinase activity
ACIFE_RS05160	COG0531	amino acid
ACIFE_RS05180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACIFE_RS05185	COG0215	cysteine-tRNA ligase activity
ACIFE_RS05190	COG1530	ribonuclease E activity
ACIFE_RS05215	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ACIFE_RS05225	COG1959	2 iron, 2 sulfur cluster binding
ACIFE_RS05230	COG1104	cysteine desulfurase activity
ACIFE_RS05235	COG0822	iron-sulfur transferase activity
ACIFE_RS05245	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ACIFE_RS05250	COG0443	Heat shock 70 kDa protein
ACIFE_RS05265	COG0482	sulfurtransferase activity
ACIFE_RS05270	COG1752	Esterase of the alpha-beta hydrolase superfamily
ACIFE_RS05285	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ACIFE_RS05295	COG2022	thiamine diphosphate biosynthetic process
ACIFE_RS05305	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACIFE_RS05310	COG0163	prenyltransferase activity
ACIFE_RS05315	COG1127	ABC transporter
ACIFE_RS05320	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACIFE_RS05340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ACIFE_RS05355	COG0577	efflux transmembrane transporter activity
ACIFE_RS05360	COG1136	(ABC) transporter
ACIFE_RS05380	COG0254	rRNA binding
ACIFE_RS05385	COG0281	malic enzyme
ACIFE_RS05390	COG0628	permease
ACIFE_RS05395	COG0129	dihydroxy-acid dehydratase activity
ACIFE_RS05405	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ACIFE_RS05405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACIFE_RS05410	COG0271	Belongs to the BolA IbaG family
ACIFE_RS05415	COG2350	Protein conserved in bacteria
ACIFE_RS05420	COG2917	probably involved in intracellular septation
ACIFE_RS05435	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ACIFE_RS05440	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
ACIFE_RS05485	COG4456	Virulence-associated protein
ACIFE_RS05495	COG0662	Cupin 2, conserved barrel domain protein
ACIFE_RS05495	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ACIFE_RS05605	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACIFE_RS05610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACIFE_RS05620	COG0489	protein tyrosine kinase activity
ACIFE_RS05620	COG3206	protein involved in exopolysaccharide biosynthesis
ACIFE_RS05625	COG1596	polysaccharide export
ACIFE_RS05715	COG3077	Addiction module antitoxin, RelB DinJ family
ACIFE_RS05735	COG1902	pentaerythritol trinitrate reductase activity
ACIFE_RS05740	COG0412	Dienelactone hydrolase
ACIFE_RS05760	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ACIFE_RS05765	COG0525	valine-tRNA ligase activity
ACIFE_RS05775	COG2927	DNA polymerase III (CHI subunit)
ACIFE_RS05780	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACIFE_RS05785	COG0795	lipopolysaccharide-transporting ATPase activity
ACIFE_RS05810	COG1965	Belongs to the frataxin family
ACIFE_RS05815	COG0514	ATP-dependent DNA helicase (RecQ)
ACIFE_RS05820	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ACIFE_RS05835	COG3842	ATPase activity
ACIFE_RS05840	COG0268	Binds directly to 16S ribosomal RNA
ACIFE_RS05845	COG0210	DNA helicase
ACIFE_RS05860	COG1187	pseudouridine synthase activity
ACIFE_RS05870	COG0494	nUDIX hydrolase
ACIFE_RS05880	COG1649	PFAM Uncharacterised BCR, COG1649
ACIFE_RS05880	COG0726	polysaccharide deacetylase
ACIFE_RS05885	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ACIFE_RS05905	COG1850	ribulose-bisphosphate carboxylase activity
ACIFE_RS05910	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIFE_RS05915	COG3261	NADH dehydrogenase
ACIFE_RS05915	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ACIFE_RS05920	COG0651	ATP synthesis coupled electron transport
ACIFE_RS05930	COG0650	Formate hydrogenlyase subunit 4
ACIFE_RS05935	COG0651	ATP synthesis coupled electron transport
ACIFE_RS05940	COG1396	sequence-specific DNA binding
ACIFE_RS05945	COG0012	GTP binding
ACIFE_RS05950	COG0193	aminoacyl-tRNA hydrolase activity
ACIFE_RS05955	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ACIFE_RS05960	COG0768	penicillin binding
ACIFE_RS05975	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ACIFE_RS05990	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ACIFE_RS06010	COG0442	prolyl-tRNA aminoacylation
ACIFE_RS06030	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ACIFE_RS06035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACIFE_RS06040	COG1562	ergosterol biosynthetic process
ACIFE_RS06045	COG1657	PFAM Prenyltransferase squalene oxidase
ACIFE_RS06055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACIFE_RS06065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACIFE_RS06070	COG3394	polysaccharide catabolic process
ACIFE_RS06085	COG0535	radical SAM domain protein
ACIFE_RS06100	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACIFE_RS06105	COG0154	amidase activity
ACIFE_RS06110	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACIFE_RS06120	COG0513	Belongs to the DEAD box helicase family
ACIFE_RS06125	COG0745	RESPONSE REGULATOR receiver
ACIFE_RS06135	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ACIFE_RS06140	COG0573	inorganic phosphate transmembrane transporter activity
ACIFE_RS06145	COG0581	inorganic phosphate transmembrane transporter activity
ACIFE_RS06150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACIFE_RS06155	COG0704	Plays a role in the regulation of phosphate uptake
ACIFE_RS06175	COG0052	Belongs to the universal ribosomal protein uS2 family
ACIFE_RS06180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACIFE_RS06185	COG0528	UMP kinase activity
ACIFE_RS06195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACIFE_RS06200	COG0575	Belongs to the CDS family
ACIFE_RS06205	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ACIFE_RS06225	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACIFE_RS06230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACIFE_RS06235	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACIFE_RS06240	COG0673	inositol 2-dehydrogenase activity
ACIFE_RS06255	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACIFE_RS06265	COG0825	malonyl-CoA metabolic process
ACIFE_RS06270	COG0037	tRNA processing
ACIFE_RS06275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACIFE_RS06280	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ACIFE_RS06285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACIFE_RS06290	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ACIFE_RS06305	COG1215	transferase activity, transferring glycosyl groups
ACIFE_RS06310	COG1215	transferase activity, transferring glycosyl groups
ACIFE_RS06315	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ACIFE_RS06325	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ACIFE_RS06340	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ACIFE_RS06385	COG1230	cation diffusion facilitator family transporter
ACIFE_RS06390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACIFE_RS06390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACIFE_RS06400	COG0477	Major facilitator Superfamily
ACIFE_RS06450	COG1064	alcohol dehydrogenase
ACIFE_RS06455	COG0504	CTP synthase activity
ACIFE_RS06460	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ACIFE_RS06465	COG0148	phosphopyruvate hydratase activity
ACIFE_RS06470	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ACIFE_RS06475	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACIFE_RS06485	COG0322	excinuclease ABC activity
ACIFE_RS06505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACIFE_RS06510	COG0640	Transcriptional regulator
ACIFE_RS06515	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ACIFE_RS06520	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ACIFE_RS06530	COG0436	Aminotransferase
ACIFE_RS06535	COG1132	(ABC) transporter
ACIFE_RS06610	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ACIFE_RS06615	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ACIFE_RS06625	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ACIFE_RS06635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACIFE_RS06640	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ACIFE_RS06650	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACIFE_RS06655	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ACIFE_RS06665	COG0776	regulation of translation
ACIFE_RS06670	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ACIFE_RS06675	COG0284	orotidine-5'-phosphate decarboxylase activity
ACIFE_RS06680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACIFE_RS06685	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACIFE_RS06690	COG0740	serine-type endopeptidase activity
ACIFE_RS06695	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACIFE_RS06700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACIFE_RS06720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACIFE_RS06730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACIFE_RS06740	COG0308	aminopeptidase N
ACIFE_RS06750	COG3025	triphosphatase activity
ACIFE_RS06765	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACIFE_RS06770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACIFE_RS06775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIFE_RS06790	COG0424	maF-like protein
ACIFE_RS06795	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ACIFE_RS06800	COG1923	regulation of RNA biosynthetic process
ACIFE_RS06805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ACIFE_RS06810	COG0330	HflC and HflK could
ACIFE_RS06815	COG0330	HflC and HflK could
ACIFE_RS06820	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ACIFE_RS06855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACIFE_RS06860	COG1058	Belongs to the CinA family
ACIFE_RS06860	COG1546	Belongs to the CinA family
ACIFE_RS06865	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ACIFE_RS06870	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACIFE_RS06880	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACIFE_RS06885	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACIFE_RS06890	COG1959	2 iron, 2 sulfur cluster binding
ACIFE_RS06890	COG1295	ribonuclease BN
ACIFE_RS06900	COG0416	fatty acid biosynthetic process
ACIFE_RS06905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACIFE_RS06910	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ACIFE_RS06920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACIFE_RS06925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACIFE_RS06935	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ACIFE_RS06940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACIFE_RS06985	COG2181	nitrate reductase activity
ACIFE_RS06990	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ACIFE_RS06995	COG1140	nitrate reductase beta subunit
ACIFE_RS07000	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ACIFE_RS07005	COG2223	nitrite transmembrane transporter activity
ACIFE_RS07060	COG2197	response regulator
ACIFE_RS07075	COG0133	tryptophan synthase activity
ACIFE_RS07085	COG0697	spore germination
ACIFE_RS07090	COG0640	Transcriptional regulator
ACIFE_RS07095	COG2378	regulation of single-species biofilm formation
ACIFE_RS07125	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACIFE_RS07130	COG0431	NADPH-dependent FMN reductase
ACIFE_RS07165	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACIFE_RS07185	COG3550	peptidyl-serine autophosphorylation
ACIFE_RS07200	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ACIFE_RS07205	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ACIFE_RS07210	COG0004	ammonium transporteR
ACIFE_RS07215	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ACIFE_RS07215	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACIFE_RS07220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACIFE_RS07230	COG0802	atpase or kinase
ACIFE_RS07235	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ACIFE_RS07240	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ACIFE_RS07245	COG0105	UTP biosynthetic process
ACIFE_RS07250	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACIFE_RS07265	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ACIFE_RS07270	COG0124	histidyl-tRNA synthetase
ACIFE_RS07280	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACIFE_RS07285	COG1160	GTP binding
ACIFE_RS07335	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ACIFE_RS07350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACIFE_RS07530	COG0326	Molecular chaperone. Has ATPase activity
ACIFE_RS07595	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ACIFE_RS07600	COG0457	Tetratricopeptide repeat
ACIFE_RS07610	COG1024	Enoyl-CoA hydratase
ACIFE_RS07615	COG2205	protein histidine kinase activity
ACIFE_RS07615	COG0784	Response regulator, receiver
ACIFE_RS07615	COG2198	Histidine kinase
ACIFE_RS07625	COG1215	transferase activity, transferring glycosyl groups
ACIFE_RS07630	COG1215	transferase activity, transferring glycosyl groups
ACIFE_RS07645	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ACIFE_RS07670	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ACIFE_RS07675	COG1196	nuclear chromosome segregation
ACIFE_RS07685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACIFE_RS07710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACIFE_RS07715	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ACIFE_RS07720	COG1166	arginine decarboxylase activity
ACIFE_RS07745	COG3411	Ferredoxin
ACIFE_RS07760	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ACIFE_RS07790	COG2146	nitrite reductase [NAD(P)H] activity
ACIFE_RS07860	COG5420	small protein containing a coiled-coil domain
ACIFE_RS07875	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ACIFE_RS07880	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ACIFE_RS07895	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ACIFE_RS07905	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
ACIFE_RS07935	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACIFE_RS07940	COG0316	Belongs to the HesB IscA family
ACIFE_RS07970	COG1104	cysteine desulfurase activity
ACIFE_RS07975	COG5554	nitrogen fixation
ACIFE_RS07985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACIFE_RS07990	COG0633	Ferredoxin
ACIFE_RS08015	COG1012	belongs to the aldehyde dehydrogenase family
ACIFE_RS08040	COG0438	transferase activity, transferring glycosyl groups
ACIFE_RS08045	COG0438	transferase activity, transferring glycosyl groups
ACIFE_RS08050	COG5654	RES domain protein
ACIFE_RS08065	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACIFE_RS08090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACIFE_RS08110	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ACIFE_RS08115	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACIFE_RS08120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACIFE_RS08125	COG0531	amino acid
ACIFE_RS08135	COG1570	exodeoxyribonuclease VII activity
ACIFE_RS08140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACIFE_RS08150	COG2223	nitrite transmembrane transporter activity
ACIFE_RS08155	COG1722	exodeoxyribonuclease VII activity
ACIFE_RS08160	COG0142	geranyltranstransferase activity
ACIFE_RS08165	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACIFE_RS08170	COG1469	GTP cyclohydrolase I activity
ACIFE_RS08175	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACIFE_RS08190	COG0438	transferase activity, transferring glycosyl groups
ACIFE_RS08195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACIFE_RS08205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACIFE_RS08245	COG4454	pyrroloquinoline quinone binding
ACIFE_RS08255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACIFE_RS08265	COG1487	ribonuclease activity
ACIFE_RS08290	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ACIFE_RS08310	COG0671	phosphoesterase, PA-phosphatase related
ACIFE_RS08365	COG2911	Protein conserved in bacteria
ACIFE_RS08370	COG0729	surface antigen
ACIFE_RS08400	COG0477	Major facilitator Superfamily
ACIFE_RS08405	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ACIFE_RS08410	COG0037	tRNA processing
ACIFE_RS08415	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACIFE_RS08415	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACIFE_RS08425	COG0736	holo-[acyl-carrier-protein] synthase activity
ACIFE_RS08430	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ACIFE_RS08435	COG1381	Involved in DNA repair and RecF pathway recombination
ACIFE_RS08440	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACIFE_RS08445	COG0571	ribonuclease III activity
ACIFE_RS08455	COG0681	Belongs to the peptidase S26 family
ACIFE_RS08460	COG0481	GTPase activity
ACIFE_RS08465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACIFE_RS08480	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ACIFE_RS08510	COG0321	lipoyl(octanoyl) transferase activity
ACIFE_RS08510	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ACIFE_RS08515	COG0084	hydrolase, TatD family'
ACIFE_RS08535	COG0628	permease
ACIFE_RS08540	COG0613	PHP domain protein
ACIFE_RS08550	COG0450	alkyl hydroperoxide reductase
ACIFE_RS08555	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ACIFE_RS08560	COG1132	(ABC) transporter
ACIFE_RS08575	COG0714	Associated with various cellular activities
ACIFE_RS08580	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACIFE_RS08585	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACIFE_RS08595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACIFE_RS08600	COG1666	GTP binding
ACIFE_RS08605	COG0314	molybdopterin synthase activity
ACIFE_RS08610	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ACIFE_RS08615	COG0616	signal peptide processing
ACIFE_RS08625	COG2363	Small membrane protein
ACIFE_RS08640	COG3416	Protein conserved in bacteria
ACIFE_RS08640	COG2943	transferase activity, transferring hexosyl groups
ACIFE_RS08655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACIFE_RS08665	COG0400	carboxylic ester hydrolase activity
ACIFE_RS08670	COG2204	response regulator
ACIFE_RS08675	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ACIFE_RS08710	COG0488	(ABC) transporter
ACIFE_RS08725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ACIFE_RS08770	COG0409	Hydrogenase expression formation protein
ACIFE_RS08780	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ACIFE_RS08790	COG0375	protein maturation
ACIFE_RS08805	COG2137	regulation of response to DNA damage stimulus
ACIFE_RS08810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACIFE_RS08815	COG1058	Belongs to the CinA family
ACIFE_RS08815	COG1546	Belongs to the CinA family
ACIFE_RS08820	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ACIFE_RS08830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACIFE_RS08835	COG1489	DNA binding
ACIFE_RS08840	COG0024	Methionine aminopeptidase
ACIFE_RS08845	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ACIFE_RS08850	COG2915	High frequency lysogenization protein hflD homolog
ACIFE_RS08890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACIFE_RS08895	COG1333	cytochrome c biogenesis protein
ACIFE_RS08925	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ACIFE_RS08935	COG2814	Major facilitator Superfamily
ACIFE_RS08940	COG0109	protoheme IX farnesyltransferase activity
ACIFE_RS08960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACIFE_RS08965	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ACIFE_RS08985	COG2363	Small membrane protein
ACIFE_RS08995	COG3002	Belongs to the UPF0753 family
ACIFE_RS09000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACIFE_RS09015	COG0418	dihydroorotase activity
ACIFE_RS09020	COG0129	dihydroxy-acid dehydratase activity
ACIFE_RS09025	COG3247	response to pH
ACIFE_RS09040	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACIFE_RS09135	COG3451	type IV secretory pathway VirB4
ACIFE_RS09160	COG4962	Type ii secretion system protein e
ACIFE_RS09175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ACIFE_RS09260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACIFE_RS09260	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACIFE_RS09375	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ACIFE_RS09380	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ACIFE_RS09390	COG0776	regulation of translation
ACIFE_RS09405	COG0776	regulation of translation
ACIFE_RS09450	COG0675	Transposase, IS605 OrfB family
ACIFE_RS09550	COG1475	DNA binding
ACIFE_RS09560	COG3969	phosphoadenosine phosphosulfate
ACIFE_RS09580	COG0791	NLP P60 protein
ACIFE_RS09580	COG0741	lytic transglycosylase activity
ACIFE_RS09590	COG0402	S-adenosylhomocysteine deaminase activity
ACIFE_RS09595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACIFE_RS09610	COG0436	Aminotransferase
ACIFE_RS09615	COG2171	N-acyltransferase activity
ACIFE_RS09620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACIFE_RS09635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACIFE_RS09635	COG0574	Belongs to the PEP-utilizing enzyme family
ACIFE_RS09640	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ACIFE_RS09645	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACIFE_RS09650	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACIFE_RS09655	COG0477	Major facilitator Superfamily
ACIFE_RS09660	COG0280	phosphate acetyltransferase
ACIFE_RS09665	COG1105	Belongs to the carbohydrate kinase PfkB family
ACIFE_RS09725	COG1187	pseudouridine synthase activity
ACIFE_RS09730	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACIFE_RS09735	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ACIFE_RS09740	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ACIFE_RS09745	COG0180	Tryptophanyl-tRNA synthetase
ACIFE_RS09750	COG1994	Peptidase M50
ACIFE_RS09755	COG0009	L-threonylcarbamoyladenylate synthase
ACIFE_RS09775	COG3264	Mechanosensitive ion channel
ACIFE_RS09775	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ACIFE_RS09780	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ACIFE_RS09785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACIFE_RS09785	COG0519	Catalyzes the synthesis of GMP from XMP
ACIFE_RS09795	COG0463	Glycosyl transferase, family 2
ACIFE_RS09805	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ACIFE_RS09805	COG0617	tRNA 3'-terminal CCA addition
ACIFE_RS09805	COG3620	sequence-specific DNA binding
ACIFE_RS09810	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ACIFE_RS09815	COG1428	Deoxynucleoside kinase
ACIFE_RS09820	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACIFE_RS09825	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ACIFE_RS09830	COG0277	FAD linked oxidase domain protein
ACIFE_RS09840	COG1193	negative regulation of DNA recombination
ACIFE_RS09855	COG0670	Belongs to the BI1 family
ACIFE_RS09895	COG0583	DNA-binding transcription factor activity
ACIFE_RS09905	COG1538	Outer membrane efflux protein
ACIFE_RS09910	COG1566	PFAM secretion protein HlyD family protein
ACIFE_RS09935	COG0509	glycine decarboxylation via glycine cleavage system
ACIFE_RS09940	COG3189	MarR family transcriptional regulator
ACIFE_RS09950	COG1116	anion transmembrane transporter activity
ACIFE_RS09950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ACIFE_RS09955	COG2223	nitrite transmembrane transporter activity
ACIFE_RS09965	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACIFE_RS09970	COG2146	nitrite reductase [NAD(P)H] activity
ACIFE_RS09975	COG0243	molybdopterin cofactor binding
ACIFE_RS09980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACIFE_RS09985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACIFE_RS09985	COG1648	precorrin-2 dehydrogenase activity
ACIFE_RS09995	COG3707	response regulator
ACIFE_RS10020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACIFE_RS10030	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ACIFE_RS10055	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ACIFE_RS10070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACIFE_RS10150	COG0038	chloride channel
ACIFE_RS10155	COG3093	addiction module antidote protein HigA
ACIFE_RS10160	COG1741	Belongs to the pirin family
ACIFE_RS10165	COG0741	lytic transglycosylase activity
ACIFE_RS10180	COG0187	DNA topoisomerase II activity
ACIFE_RS10190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACIFE_RS10205	COG0642	Histidine kinase
ACIFE_RS10290	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACIFE_RS10295	COG0469	pyruvate kinase activity
ACIFE_RS10295	COG0469	pyruvate kinase activity
ACIFE_RS10305	COG0688	phosphatidylethanolamine metabolic process
ACIFE_RS10310	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ACIFE_RS10320	COG0028	Belongs to the TPP enzyme family
ACIFE_RS10325	COG1193	negative regulation of DNA recombination
ACIFE_RS10335	COG0432	Pfam Uncharacterised protein family UPF0047
ACIFE_RS10370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACIFE_RS10375	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACIFE_RS10380	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ACIFE_RS10385	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ACIFE_RS10390	COG0067	glutamate synthase
ACIFE_RS10390	COG0069	glutamate synthase activity
ACIFE_RS10390	COG0070	glutamate synthase
ACIFE_RS10395	COG0493	'glutamate synthase
ACIFE_RS10400	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACIFE_RS10430	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACIFE_RS10460	COG3645	SOS response
ACIFE_RS10485	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACIFE_RS10490	COG1862	Preprotein translocase
ACIFE_RS10495	COG0343	queuine tRNA-ribosyltransferase activity
ACIFE_RS10500	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ACIFE_RS10505	COG1253	flavin adenine dinucleotide binding
ACIFE_RS10520	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ACIFE_RS10530	COG0285	dihydrofolate synthase activity
ACIFE_RS10535	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ACIFE_RS10540	COG0159	tryptophan synthase activity
ACIFE_RS10545	COG0133	tryptophan synthase activity
ACIFE_RS10550	COG0135	phosphoribosylanthranilate isomerase activity
ACIFE_RS10555	COG0101	tRNA pseudouridine synthase activity
ACIFE_RS10565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ACIFE_RS10580	COG0746	molybdenum cofactor guanylyltransferase activity
ACIFE_RS10585	COG1763	Mo-molybdopterin cofactor biosynthetic process
ACIFE_RS10590	COG0303	'Molybdopterin
ACIFE_RS10595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACIFE_RS10605	COG2078	PFAM AMMECR1 domain protein
ACIFE_RS10610	COG1355	regulation of microtubule-based process
ACIFE_RS10630	COG0628	permease
ACIFE_RS10660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACIFE_RS10665	COG1758	RNA polymerase activity
ACIFE_RS10670	COG0194	GDP metabolic process
ACIFE_RS10675	COG1561	YicC-like family, N-terminal region
ACIFE_RS10705	COG1850	ribulose-bisphosphate carboxylase activity
ACIFE_RS10715	COG1131	(ABC) transporter
ACIFE_RS10720	COG0842	Transport permease protein
ACIFE_RS10725	COG0842	Transport permease protein
ACIFE_RS10730	COG0776	regulation of translation
ACIFE_RS10760	COG1715	Restriction endonuclease
ACIFE_RS10795	COG2026	Addiction module toxin, RelE StbE family
ACIFE_RS10800	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ACIFE_RS10825	COG1538	Outer membrane efflux protein
ACIFE_RS10840	COG0196	riboflavin kinase activity
ACIFE_RS10845	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACIFE_RS10850	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACIFE_RS10870	COG4178	(ABC) transporter
ACIFE_RS10880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACIFE_RS10890	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ACIFE_RS10905	COG4232	protein-disulfide reductase activity
ACIFE_RS10915	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ACIFE_RS10920	COG0459	protein refolding
ACIFE_RS10935	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACIFE_RS10940	COG0529	Catalyzes the synthesis of activated sulfate
ACIFE_RS10940	COG2046	Belongs to the sulfate adenylyltransferase family
ACIFE_RS10960	COG0243	molybdopterin cofactor binding
ACIFE_RS10970	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ACIFE_RS10975	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ACIFE_RS11035	COG0542	response to heat
ACIFE_RS11040	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ACIFE_RS11065	COG1484	DNA-dependent DNA replication
ACIFE_RS11100	COG3344	reverse transcriptase
ACIFE_RS11150	COG0582	viral genome integration into host DNA
ACIFE_RS11155	COG0582	viral genome integration into host DNA
ACIFE_RS11170	COG1064	alcohol dehydrogenase
ACIFE_RS11205	COG1028	Short-chain dehydrogenase reductase Sdr
ACIFE_RS11210	COG4638	Rieske (2fe-2S)
ACIFE_RS11260	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ACIFE_RS11295	COG0419	ATPase involved in DNA repair
ACIFE_RS11300	COG0420	3'-5' exonuclease activity
ACIFE_RS11325	COG2865	translation initiation factor activity
ACIFE_RS11365	COG4372	Transposase
ACIFE_RS11390	COG1193	negative regulation of DNA recombination
ACIFE_RS11400	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ACIFE_RS11405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACIFE_RS11410	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACIFE_RS11415	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ACIFE_RS11430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACIFE_RS11450	COG1686	Belongs to the peptidase S11 family
ACIFE_RS11480	COG4691	Plasmid stability protein
ACIFE_RS11495	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
ACIFE_RS11505	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACIFE_RS11505	COG0047	phosphoribosylformylglycinamidine synthase activity
ACIFE_RS11510	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ACIFE_RS11515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACIFE_RS11525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACIFE_RS11535	COG1272	protein, Hemolysin III
ACIFE_RS11540	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACIFE_RS11550	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ACIFE_RS11570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIFE_RS11580	COG0640	Transcriptional regulator
ACIFE_RS11590	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACIFE_RS11605	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ACIFE_RS11610	COG0084	hydrolase, TatD family'
ACIFE_RS11615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACIFE_RS11620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACIFE_RS11625	COG2960	long-chain fatty acid transporting porin activity
ACIFE_RS11660	COG1199	ATP-dependent helicase activity
ACIFE_RS11680	COG0791	NLP P60 protein
ACIFE_RS11700	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ACIFE_RS11715	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ACIFE_RS11720	COG0586	Pfam SNARE associated Golgi protein
ACIFE_RS11735	COG0583	DNA-binding transcription factor activity
ACIFE_RS11750	COG0123	including yeast histone deacetylase and acetoin utilization protein
ACIFE_RS11800	COG0644	oxidoreductase
ACIFE_RS11805	COG0095	Lipoate-protein ligase
ACIFE_RS11815	COG0509	glycine decarboxylation via glycine cleavage system
ACIFE_RS11825	COG0509	glycine decarboxylation via glycine cleavage system
ACIFE_RS11830	COG2048	Heterodisulfide reductase, subunit B
ACIFE_RS11860	COG2210	Belongs to the sulfur carrier protein TusA family
ACIFE_RS11865	COG0425	Belongs to the sulfur carrier protein TusA family
ACIFE_RS11870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACIFE_RS11875	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACIFE_RS11885	COG0437	4 iron, 4 sulfur cluster binding
ACIFE_RS11890	COG0243	molybdopterin cofactor binding
ACIFE_RS11900	COG0315	cyclic pyranopterin monophosphate synthase activity
ACIFE_RS11910	COG3852	Histidine kinase
ACIFE_RS11915	COG2204	response regulator
ACIFE_RS11935	COG3439	Domain of unknown function DUF302
ACIFE_RS11940	COG0737	Belongs to the 5'-nucleotidase family
ACIFE_RS11945	COG1077	Cell shape determining protein MreB Mrl
ACIFE_RS11950	COG1792	Involved in formation and maintenance of cell shape
ACIFE_RS11965	COG0772	Belongs to the SEDS family
ACIFE_RS11970	COG1686	Belongs to the peptidase S11 family
ACIFE_RS11980	COG0321	lipoyl(octanoyl) transferase activity
ACIFE_RS11985	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACIFE_RS11990	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ACIFE_RS12035	COG0751	glycine-tRNA ligase activity
ACIFE_RS12040	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ACIFE_RS12045	COG0204	Acyl-transferase
ACIFE_RS12050	COG0189	ligase activity
ACIFE_RS12070	COG2154	pterin-4-alpha-carbinolamine dehydratase
ACIFE_RS12075	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ACIFE_RS12095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACIFE_RS12130	COG0776	regulation of translation
ACIFE_RS12135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACIFE_RS12135	COG0072	phenylalanine-tRNA ligase activity
ACIFE_RS12140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACIFE_RS12145	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACIFE_RS12150	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ACIFE_RS12155	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ACIFE_RS12160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACIFE_RS12175	COG1007	ATP synthesis coupled electron transport
ACIFE_RS12190	COG0713	ATP synthesis coupled electron transport
ACIFE_RS12200	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIFE_RS12205	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACIFE_RS12210	COG1034	ATP synthesis coupled electron transport
ACIFE_RS12215	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ACIFE_RS12220	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ACIFE_RS12225	COG0649	NAD binding
ACIFE_RS12230	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIFE_RS12235	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIFE_RS12240	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIFE_RS12255	COG0149	triose-phosphate isomerase activity
ACIFE_RS12260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACIFE_RS12265	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACIFE_RS12270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACIFE_RS12275	COG0312	modulator of DNA gyrase
ACIFE_RS12285	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACIFE_RS12370	COG0697	spore germination
ACIFE_RS12405	COG1845	cytochrome c oxidase, subunit III
ACIFE_RS12410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACIFE_RS12415	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ACIFE_RS12435	COG4993	Dehydrogenase
ACIFE_RS12435	COG2010	Cytochrome c
ACIFE_RS12460	COG0776	regulation of translation
ACIFE_RS12490	COG0076	glutamate decarboxylase activity
ACIFE_RS12500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACIFE_RS12515	COG2433	Pfam Transposase IS66
ACIFE_RS12525	COG1252	NADH dehydrogenase
ACIFE_RS12540	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ACIFE_RS12545	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACIFE_RS12550	COG0175	sulfate reduction
ACIFE_RS12560	COG2895	sulfate adenylyltransferase (ATP) activity
ACIFE_RS12565	COG1648	precorrin-2 dehydrogenase activity
ACIFE_RS12565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACIFE_RS12590	COG0527	aspartate kinase activity
ACIFE_RS12595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACIFE_RS12600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACIFE_RS12605	COG0137	argininosuccinate synthase activity
ACIFE_RS12615	COG0346	lactoylglutathione lyase activity
ACIFE_RS12620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ACIFE_RS12625	COG0328	RNA-DNA hybrid ribonuclease activity
ACIFE_RS12635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACIFE_RS12640	COG0612	Peptidase, M16
ACIFE_RS12645	COG1185	polyribonucleotide nucleotidyltransferase activity
ACIFE_RS12650	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACIFE_RS12655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACIFE_RS12660	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACIFE_RS12665	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACIFE_RS12670	COG0195	Participates in both transcription termination and antitermination
ACIFE_RS12670	COG2251	uridine kinase activity
ACIFE_RS12675	COG0779	Required for maturation of 30S ribosomal subunits
ACIFE_RS12710	COG1376	ErfK ybiS ycfS ynhG family protein
ACIFE_RS12720	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACIFE_RS12725	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ACIFE_RS12735	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ACIFE_RS12745	COG0492	ferredoxin-NADP+ reductase activity
ACIFE_RS12765	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACIFE_RS12770	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACIFE_RS12775	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ACIFE_RS12785	COG0560	Phosphoserine phosphatase
ACIFE_RS12790	COG0678	peroxiredoxin activity
ACIFE_RS12790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ACIFE_RS12795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACIFE_RS12805	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ACIFE_RS12825	COG0671	phosphoesterase, PA-phosphatase related
ACIFE_RS12835	COG2003	Belongs to the UPF0758 family
ACIFE_RS12840	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACIFE_RS12845	COG0756	dUTP diphosphatase activity
ACIFE_RS12850	COG0203	ribosomal protein L17
ACIFE_RS12855	COG0202	RNA polymerase activity
ACIFE_RS12860	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACIFE_RS12865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ACIFE_RS12870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACIFE_RS12875	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACIFE_RS12880	COG0563	adenylate kinase activity
ACIFE_RS12885	COG0201	protein transport
ACIFE_RS12890	COG0200	Binds to the 23S rRNA
ACIFE_RS12895	COG1841	ribosomal large subunit assembly
ACIFE_RS12900	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACIFE_RS12905	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACIFE_RS12910	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACIFE_RS12915	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACIFE_RS12920	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACIFE_RS12925	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ACIFE_RS12930	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACIFE_RS12935	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACIFE_RS12940	COG0255	Belongs to the universal ribosomal protein uL29 family
ACIFE_RS12945	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACIFE_RS12955	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACIFE_RS12960	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACIFE_RS12965	COG0089	rRNA binding
ACIFE_RS12970	COG0088	Forms part of the polypeptide exit tunnel
ACIFE_RS12975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACIFE_RS12980	COG0051	transcription antitermination factor activity, RNA binding
ACIFE_RS12985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACIFE_RS12990	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACIFE_RS12995	COG0049	tRNA binding
ACIFE_RS13000	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACIFE_RS13005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACIFE_RS13010	COG0085	RNA polymerase activity
ACIFE_RS13015	COG0222	ribosome binding
ACIFE_RS13020	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACIFE_RS13025	COG0081	regulation of translation
ACIFE_RS13030	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACIFE_RS13050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACIFE_RS13075	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACIFE_RS13100	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACIFE_RS13115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACIFE_RS13115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACIFE_RS13120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACIFE_RS13125	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACIFE_RS13135	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACIFE_RS13140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACIFE_RS13140	COG2813	Specifically methylates the guanine in position
ACIFE_RS13150	COG2226	methyltransferase
ACIFE_RS13155	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ACIFE_RS13160	COG0288	reversible hydration of carbon dioxide
ACIFE_RS13165	COG0659	secondary active sulfate transmembrane transporter activity
ACIFE_RS13170	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ACIFE_RS13175	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ACIFE_RS13180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACIFE_RS13185	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ACIFE_RS13190	COG0735	belongs to the Fur family
ACIFE_RS13195	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACIFE_RS13205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACIFE_RS13210	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACIFE_RS13230	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ACIFE_RS13235	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACIFE_RS13240	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ACIFE_RS13275	COG1872	DUF167
ACIFE_RS13280	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACIFE_RS13295	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACIFE_RS13300	COG1309	transcriptional regulator
ACIFE_RS13320	COG0543	2 iron, 2 sulfur cluster binding
ACIFE_RS13320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACIFE_RS13325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ACIFE_RS13330	COG0390	transport system, permease component
ACIFE_RS13335	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ACIFE_RS13340	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ACIFE_RS13350	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ACIFE_RS13355	COG2226	methyltransferase
ACIFE_RS13365	COG0156	8-amino-7-oxononanoate synthase activity
ACIFE_RS13370	COG1040	competence protein
ACIFE_RS13375	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ACIFE_RS13380	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACIFE_RS13385	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ACIFE_RS13390	COG1560	Kdo2-lipid A biosynthetic process
ACIFE_RS13395	COG1519	Transferase
ACIFE_RS13425	COG0438	transferase activity, transferring glycosyl groups
ACIFE_RS13430	COG0726	polysaccharide deacetylase
ACIFE_RS13435	COG0463	Glycosyl transferase, family 2
ACIFE_RS13440	COG0494	nUDIX hydrolase
ACIFE_RS13445	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ACIFE_RS13450	COG0653	protein targeting
ACIFE_RS13460	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ACIFE_RS13465	COG0625	glutathione transferase activity
ACIFE_RS13470	COG1022	Amp-dependent synthetase and ligase
ACIFE_RS13475	COG0617	tRNA 3'-terminal CCA addition
ACIFE_RS13480	COG2001	Belongs to the MraZ family
ACIFE_RS13485	COG0275	rRNA processing
ACIFE_RS13500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACIFE_RS13505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ACIFE_RS13510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACIFE_RS13515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACIFE_RS13520	COG0772	Belongs to the SEDS family
ACIFE_RS13525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACIFE_RS13530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACIFE_RS13535	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ACIFE_RS13540	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACIFE_RS13555	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACIFE_RS13570	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ACIFE_RS13575	COG0511	ligase activity, forming carbon-carbon bonds
ACIFE_RS13580	COG0439	Biotin carboxylase
ACIFE_RS13585	COG2264	protein methyltransferase activity
ACIFE_RS13595	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ACIFE_RS13600	COG0739	heme binding
ACIFE_RS13600	COG0741	lytic transglycosylase activity
ACIFE_RS13600	COG1196	nuclear chromosome segregation
ACIFE_RS13605	COG2969	positive regulation of protein catabolic process
ACIFE_RS13640	COG0475	glutathione-regulated potassium exporter activity
ACIFE_RS13645	COG1028	Short-chain dehydrogenase reductase Sdr
ACIFE_RS13690	COG0318	PFAM AMP-dependent synthetase and ligase
ACIFE_RS13705	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ACIFE_RS13710	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
ACIFE_RS13715	COG0237	dephospho-CoA kinase activity
ACIFE_RS13735	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACIFE_RS13740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACIFE_RS13745	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ACIFE_RS13750	COG1047	Peptidyl-prolyl cis-trans
ACIFE_RS13755	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACIFE_RS13765	COG0625	glutathione transferase activity
ACIFE_RS13770	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ACIFE_RS13780	COG0708	Exodeoxyribonuclease III
ACIFE_RS13790	COG0477	Major facilitator Superfamily
ACIFE_RS13795	COG3264	Mechanosensitive ion channel
ACIFE_RS13795	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ACIFE_RS13800	COG0018	arginyl-trna synthetase
ACIFE_RS13815	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACIFE_RS13825	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ACIFE_RS13830	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ACIFE_RS13835	COG1131	(ABC) transporter
ACIFE_RS13850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ACIFE_RS13855	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACIFE_RS13860	COG1127	ABC transporter
ACIFE_RS13865	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ACIFE_RS13870	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ACIFE_RS13880	COG2204	response regulator
ACIFE_RS13890	COG2205	protein histidine kinase activity
ACIFE_RS13895	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ACIFE_RS13910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACIFE_RS13925	COG1660	Displays ATPase and GTPase activities
ACIFE_RS13930	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ACIFE_RS13935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACIFE_RS13935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ACIFE_RS13935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ACIFE_RS13955	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ACIFE_RS13965	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ACIFE_RS13990	COG3178	'Phosphotransferase
ACIFE_RS13995	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ACIFE_RS14000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACIFE_RS14005	COG0842	Transport permease protein
ACIFE_RS14010	COG0271	Belongs to the BolA IbaG family
ACIFE_RS14015	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ACIFE_RS14020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACIFE_RS14025	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ACIFE_RS14030	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACIFE_RS14035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACIFE_RS14040	COG0131	Imidazoleglycerol-phosphate dehydratase
ACIFE_RS14045	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ACIFE_RS14050	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACIFE_RS14055	COG0107	imidazoleglycerol-phosphate synthase activity
ACIFE_RS14060	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACIFE_RS14060	COG0140	phosphoribosyl-ATP diphosphatase activity
ACIFE_RS14065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACIFE_RS14070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACIFE_RS14075	COG0805	protein transport
ACIFE_RS14080	COG0438	transferase activity, transferring glycosyl groups
ACIFE_RS14090	COG1278	Cold shock
ACIFE_RS14110	COG3158	transport of potassium into the cell
ACIFE_RS14130	COG0540	Belongs to the ATCase OTCase family
ACIFE_RS14135	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ACIFE_RS14140	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ACIFE_RS14145	COG1678	Uncharacterized ACR, COG1678
ACIFE_RS14175	COG2801	Transposase and inactivated derivatives
ACIFE_RS14175	COG3415	Transposase
ACIFE_RS14210	COG0393	Putative heavy-metal-binding
ACIFE_RS14220	COG2337	Toxic component of a toxin-antitoxin (TA) module
ACIFE_RS14345	COG0629	single-stranded DNA binding
ACIFE_RS14370	COG0714	Associated with various cellular activities
ACIFE_RS14390	COG1994	Peptidase M50
ACIFE_RS14410	COG0457	Tetratricopeptide repeat
ACIFE_RS14430	COG0776	regulation of translation
ACIFE_RS14445	COG4974	Belongs to the 'phage' integrase family
ACIFE_RS14465	COG0546	phosphoglycolate phosphatase activity
ACIFE_RS14465	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ACIFE_RS14555	COG2337	Toxic component of a toxin-antitoxin (TA) module
ACIFE_RS14560	COG2336	PFAM SpoVT AbrB
ACIFE_RS14610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACIFE_RS14715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ACIFE_RS14755	COG0582	viral genome integration into host DNA
ACIFE_RS14760	COG0189	ligase activity
ACIFE_RS14775	COG0316	Belongs to the HesB IscA family
ACIFE_RS14780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACIFE_RS14785	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACIFE_RS14785	COG0022	dehydrogenase e1 component
ACIFE_RS14790	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ACIFE_RS14800	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACIFE_RS14805	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACIFE_RS14810	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACIFE_RS14825	COG0778	Nitroreductase
ACIFE_RS14830	COG2081	HI0933 family
ACIFE_RS14865	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ACIFE_RS14870	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ACIFE_RS14885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACIFE_RS14890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACIFE_RS14890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACIFE_RS14895	COG1611	Belongs to the LOG family
ACIFE_RS14905	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ACIFE_RS14910	COG1555	photosystem II stabilization
ACIFE_RS14915	COG0210	DNA helicase
ACIFE_RS14935	COG1796	DNA polymerase
ACIFE_RS14935	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ACIFE_RS14940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACIFE_RS14985	COG2378	regulation of single-species biofilm formation
ACIFE_RS14995	COG0454	-acetyltransferase
ACIFE_RS15020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACIFE_RS15030	COG0191	fructose-bisphosphate aldolase activity
ACIFE_RS15050	COG1192	Involved in chromosome partitioning
ACIFE_RS15065	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ACIFE_RS15070	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ACIFE_RS15120	COG2814	Major facilitator Superfamily
ACIFE_RS15135	COG0583	DNA-binding transcription factor activity
ACIFE_RS15155	COG1028	Short-chain dehydrogenase reductase Sdr
ACIFE_RS15240	COG1126	abc transporter atp-binding protein
ACIFE_RS15270	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ACIFE_RS15270	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ACIFE_RS15275	COG0631	protein serine/threonine phosphatase activity
ACIFE_RS15290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACIFE_RS15305	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACIFE_RS15310	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACIFE_RS15315	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACIFE_RS15320	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ACIFE_RS15330	COG0356	it plays a direct role in the translocation of protons across the membrane
ACIFE_RS15340	COG1475	DNA binding
ACIFE_RS15350	COG0357	Ribosomal RNA small subunit methyltransferase G
ACIFE_RS15355	COG0445	tRNA wobble uridine modification
ACIFE_RS15370	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACIFE_RS15400	COG0247	lactate metabolic process
ACIFE_RS15405	COG0277	FAD linked oxidase domain protein
ACIFE_RS15410	COG0277	FAD linked oxidase domain protein
ACIFE_RS15460	COG4372	Transposase
ACIFE_RS15470	COG3344	reverse transcriptase
ACIFE_RS15490	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACIFE_RS15590	COG1088	dTDP-glucose 4,6-dehydratase activity
ACIFE_RS15595	COG1091	dTDP-4-dehydrorhamnose reductase activity
ACIFE_RS15605	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ACIFE_RS15610	COG0477	Major facilitator Superfamily
ACIFE_RS15620	COG0113	porphobilinogen synthase activity
ACIFE_RS15630	COG0181	hydroxymethylbilane synthase activity
ACIFE_RS15640	COG0537	adenosine 5'-monophosphoramidase activity
ACIFE_RS15645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACIFE_RS15650	COG0352	thiamine-phosphate diphosphorylase activity
ACIFE_RS15655	COG0351	phosphomethylpyrimidine kinase
ACIFE_RS15675	COG2857	Cytochrome c1
ACIFE_RS15680	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ACIFE_RS15685	COG0723	plastoquinol--plastocyanin reductase activity
ACIFE_RS15690	COG1028	Short-chain dehydrogenase reductase Sdr
ACIFE_RS15710	COG0826	peptidase U32
ACIFE_RS15765	COG1396	sequence-specific DNA binding
ACIFE_RS15800	COG3561	AntA/AntB antirepressor
ACIFE_RS15810	COG3012	SEC-C Motif Domain Protein
ACIFE_RS15830	COG3300	MHYT domain
ACIFE_RS15830	COG5001	Diguanylate cyclase
ACIFE_RS15835	COG0463	Glycosyl transferase, family 2
ACIFE_RS15835	COG1216	Glycosyl transferase, family 2
ACIFE_RS15865	COG4227	nucleotidyltransferase activity
ACIFE_RS15885	COG1183	phosphatidylcholine synthase activity
ACIFE_RS15960	COG0438	transferase activity, transferring glycosyl groups
ACIFE_RS15960	COG1216	Glycosyl transferase, family 2
ACIFE_RS15965	COG3154	lipid carrier protein