locus-tag	class	description
H2515_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H2515_RS00010	COG0592	DNA-directed DNA polymerase activity
H2515_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H2515_RS00020	COG0187	DNA topoisomerase II activity
H2515_RS00035	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H2515_RS00040	COG2894	cell division
H2515_RS00045	COG0850	regulation of cytokinetic process
H2515_RS00060	COG2922	Belongs to the Smg family
H2515_RS00065	COG0758	DNA mediated transformation
H2515_RS00070	COG1705	Flagellar rod assembly protein muramidase FlgJ
H2515_RS00070	COG1388	LysM domain
H2515_RS00075	COG0242	peptide deformylase activity
H2515_RS00080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H2515_RS00085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H2515_RS00095	COG5000	phosphorelay sensor kinase activity
H2515_RS00100	COG2204	response regulator
H2515_RS00120	COG3459	Glycosyltransferase 36 associated
H2515_RS00135	COG1393	Belongs to the ArsC family
H2515_RS00155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H2515_RS00160	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H2515_RS00165	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H2515_RS00170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H2515_RS00175	COG2833	Protein of unknown function (DUF455)
H2515_RS00180	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H2515_RS00185	COG2161	toxin-antitoxin pair type II binding
H2515_RS00190	COG4115	mRNA cleavage
H2515_RS00250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2515_RS00275	COG1914	H( )-stimulated, divalent metal cation uptake system
H2515_RS00280	COG1842	Phage shock protein A
H2515_RS00285	COG0393	Putative heavy-metal-binding
H2515_RS00315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2515_RS00320	COG4521	taurine ABC transporter
H2515_RS00360	COG2188	Transcriptional regulator
H2515_RS00375	COG0583	DNA-binding transcription factor activity
H2515_RS00395	COG0277	FAD linked oxidase domain protein
H2515_RS00400	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H2515_RS00405	COG0792	nuclease activity
H2515_RS00410	COG3107	peptidoglycan biosynthetic process
H2515_RS00435	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H2515_RS00440	COG1278	Cold shock
H2515_RS00455	COG1530	ribonuclease E activity
H2515_RS00460	COG0424	maF-like protein
H2515_RS00475	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H2515_RS00485	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H2515_RS00495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H2515_RS00510	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H2515_RS00525	COG0811	peptide transport
H2515_RS00570	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H2515_RS00575	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2515_RS00580	COG1074	ATP-dependent DNA helicase activity
H2515_RS00585	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H2515_RS00595	COG3220	belongs to the UPF0276 family
H2515_RS00605	COG1560	Kdo2-lipid A biosynthetic process
H2515_RS00620	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H2515_RS00630	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H2515_RS00640	COG3260	NADH ubiquinone oxidoreductase 20
H2515_RS00645	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
H2515_RS00645	COG3261	NADH dehydrogenase
H2515_RS00650	COG0651	ATP synthesis coupled electron transport
H2515_RS00700	COG2885	chlorophyll binding
H2515_RS00710	COG0602	queuosine metabolic process
H2515_RS00715	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H2515_RS00720	COG0823	Involved in the tonB-independent uptake of proteins
H2515_RS00735	COG0811	peptide transport
H2515_RS00740	COG0824	Thioesterase
H2515_RS00745	COG2255	four-way junction helicase activity
H2515_RS00750	COG0632	four-way junction helicase activity
H2515_RS00755	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H2515_RS00760	COG0217	transcriptional regulatory protein
H2515_RS00770	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H2515_RS00775	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H2515_RS00785	COG2095	MarC family integral membrane protein
H2515_RS00795	COG0488	(ABC) transporter
H2515_RS00800	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H2515_RS00810	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H2515_RS00815	COG0706	membrane insertase activity
H2515_RS00820	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H2515_RS00855	COG1131	(ABC) transporter
H2515_RS00860	COG2945	thiolester hydrolase activity
H2515_RS00875	COG1959	2 iron, 2 sulfur cluster binding
H2515_RS00885	COG0134	indole-3-glycerol-phosphate synthase activity
H2515_RS00890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H2515_RS00960	COG0393	Putative heavy-metal-binding
H2515_RS01005	COG1104	cysteine desulfurase activity
H2515_RS01010	COG2226	methyltransferase
H2515_RS01030	COG2226	methyltransferase
H2515_RS01105	COG0629	single-stranded DNA binding
H2515_RS01125	COG0714	Associated with various cellular activities
H2515_RS01145	COG1994	Peptidase M50
H2515_RS01220	COG0457	Tetratricopeptide repeat
H2515_RS01240	COG0776	regulation of translation
H2515_RS01255	COG1487	ribonuclease activity
H2515_RS01290	COG4974	Belongs to the 'phage' integrase family
H2515_RS01345	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H2515_RS01410	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2515_RS01415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2515_RS01445	COG2217	Heavy metal translocating P-type atpase
H2515_RS01475	COG4974	Belongs to the 'phage' integrase family
H2515_RS01615	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H2515_RS01720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H2515_RS01725	COG0305	Participates in initiation and elongation during chromosome replication
H2515_RS01755	COG0582	viral genome integration into host DNA
H2515_RS01785	COG0546	phosphoglycolate phosphatase activity
H2515_RS01790	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H2515_RS01800	COG0469	pyruvate kinase activity
H2515_RS01805	COG0126	phosphoglycerate kinase activity
H2515_RS01810	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H2515_RS01815	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H2515_RS01820	COG1494	fructose-1,6-bisphosphatase
H2515_RS01825	COG0483	inositol monophosphate 1-phosphatase activity
H2515_RS01835	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H2515_RS01840	COG0598	Magnesium transport protein CorA
H2515_RS01845	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H2515_RS01850	COG1322	Protein conserved in bacteria
H2515_RS01855	COG1970	mechanosensitive ion channel activity
H2515_RS01870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2515_RS01960	COG0165	Argininosuccinate lyase
H2515_RS01975	COG0166	Belongs to the GPI family
H2515_RS01980	COG1686	Belongs to the peptidase S11 family
H2515_RS01985	COG0655	NAD(P)H dehydrogenase (quinone) activity
H2515_RS01990	COG1733	regulation of RNA biosynthetic process
H2515_RS01995	COG2353	YceI-like domain
H2515_RS02020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H2515_RS02045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H2515_RS02045	COG0519	Catalyzes the synthesis of GMP from XMP
H2515_RS02055	COG0004	ammonium transporteR
H2515_RS02070	COG0004	ammonium transporteR
H2515_RS02075	COG0347	Belongs to the P(II) protein family
H2515_RS02085	COG2719	SpoVR family
H2515_RS02090	COG2718	Belongs to the UPF0229 family
H2515_RS02095	COG0004	ammonium transporteR
H2515_RS02100	COG2766	serine protein kinase
H2515_RS02120	COG2308	Evidence 4 Homologs of previously reported genes of
H2515_RS02130	COG3852	Histidine kinase
H2515_RS02145	COG0142	geranyltranstransferase activity
H2515_RS02175	COG0488	(ABC) transporter
H2515_RS02185	COG1573	uracil-dna glycosylase
H2515_RS02280	COG0028	Belongs to the TPP enzyme family
H2515_RS02295	COG4584	PFAM Integrase catalytic
H2515_RS02315	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H2515_RS02320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H2515_RS02325	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H2515_RS02345	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H2515_RS02350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H2515_RS02360	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H2515_RS02365	COG0735	belongs to the Fur family
H2515_RS02370	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H2515_RS02375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H2515_RS02380	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H2515_RS02385	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H2515_RS02390	COG0659	secondary active sulfate transmembrane transporter activity
H2515_RS02395	COG0288	reversible hydration of carbon dioxide
H2515_RS02400	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H2515_RS02405	COG2226	methyltransferase
H2515_RS02415	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2515_RS02415	COG2813	Specifically methylates the guanine in position
H2515_RS02420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2515_RS02430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H2515_RS02435	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H2515_RS02440	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2515_RS02440	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2515_RS02455	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H2515_RS02480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H2515_RS02505	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H2515_RS02525	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H2515_RS02530	COG0081	regulation of translation
H2515_RS02535	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H2515_RS02540	COG0222	ribosome binding
H2515_RS02545	COG0085	RNA polymerase activity
H2515_RS02550	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H2515_RS02555	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H2515_RS02560	COG0049	tRNA binding
H2515_RS02565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H2515_RS02570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H2515_RS02575	COG0051	transcription antitermination factor activity, RNA binding
H2515_RS02580	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H2515_RS02585	COG0088	Forms part of the polypeptide exit tunnel
H2515_RS02590	COG0089	rRNA binding
H2515_RS02595	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H2515_RS02600	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H2515_RS02605	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H2515_RS02615	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H2515_RS02620	COG0255	Belongs to the universal ribosomal protein uL29 family
H2515_RS02625	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H2515_RS02630	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H2515_RS02635	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H2515_RS02640	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H2515_RS02645	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H2515_RS02650	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H2515_RS02655	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H2515_RS02660	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H2515_RS02665	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H2515_RS02670	COG1841	ribosomal large subunit assembly
H2515_RS02675	COG0200	Binds to the 23S rRNA
H2515_RS02680	COG0201	protein transport
H2515_RS02685	COG0563	adenylate kinase activity
H2515_RS02690	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H2515_RS02695	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H2515_RS02700	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H2515_RS02705	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H2515_RS02710	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H2515_RS02715	COG0202	RNA polymerase activity
H2515_RS02720	COG0203	ribosomal protein L17
H2515_RS02725	COG0756	dUTP diphosphatase activity
H2515_RS02730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H2515_RS02735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2515_RS02755	COG0604	alcohol dehydrogenase
H2515_RS02755	COG1028	Short-chain dehydrogenase reductase Sdr
H2515_RS02755	COG3321	synthase
H2515_RS02785	COG1216	Glycosyl transferase, family 2
H2515_RS02785	COG0438	transferase activity, transferring glycosyl groups
H2515_RS02855	COG2003	Belongs to the UPF0758 family
H2515_RS02865	COG0671	phosphoesterase, PA-phosphatase related
H2515_RS02885	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H2515_RS02895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2515_RS02900	COG0678	peroxiredoxin activity
H2515_RS02900	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H2515_RS02905	COG0560	Phosphoserine phosphatase
H2515_RS02910	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H2515_RS02915	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H2515_RS02920	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H2515_RS02925	COG0585	pseudouridine synthase activity
H2515_RS02940	COG0492	ferredoxin-NADP+ reductase activity
H2515_RS02950	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H2515_RS02960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H2515_RS02965	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H2515_RS02975	COG1376	ErfK ybiS ycfS ynhG family protein
H2515_RS03010	COG0779	Required for maturation of 30S ribosomal subunits
H2515_RS03015	COG0195	Participates in both transcription termination and antitermination
H2515_RS03015	COG2251	uridine kinase activity
H2515_RS03020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H2515_RS03025	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H2515_RS03030	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H2515_RS03035	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H2515_RS03040	COG1185	polyribonucleotide nucleotidyltransferase activity
H2515_RS03045	COG0612	Peptidase, M16
H2515_RS03050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2515_RS03060	COG0328	RNA-DNA hybrid ribonuclease activity
H2515_RS03065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H2515_RS03070	COG0346	lactoylglutathione lyase activity
H2515_RS03080	COG0137	argininosuccinate synthase activity
H2515_RS03085	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H2515_RS03090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H2515_RS03095	COG0527	aspartate kinase activity
H2515_RS03115	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H2515_RS03115	COG1648	precorrin-2 dehydrogenase activity
H2515_RS03120	COG2895	sulfate adenylyltransferase (ATP) activity
H2515_RS03130	COG0175	sulfate reduction
H2515_RS03135	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2515_RS03140	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H2515_RS03155	COG1252	NADH dehydrogenase
H2515_RS03195	COG3002	Belongs to the UPF0753 family
H2515_RS03240	COG0418	dihydroorotase activity
H2515_RS03245	COG0129	dihydroxy-acid dehydratase activity
H2515_RS03270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H2515_RS03285	COG0191	fructose-bisphosphate aldolase activity
H2515_RS03300	COG1192	Involved in chromosome partitioning
H2515_RS03315	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H2515_RS03320	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H2515_RS03325	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H2515_RS03370	COG0667	Aldo Keto reductase
H2515_RS03485	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H2515_RS03490	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H2515_RS03495	COG1845	cytochrome c oxidase, subunit III
H2515_RS03550	COG0251	oxidation-reduction process
H2515_RS03555	COG1126	abc transporter atp-binding protein
H2515_RS03610	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H2515_RS03615	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H2515_RS03615	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H2515_RS03620	COG0312	modulator of DNA gyrase
H2515_RS03625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H2515_RS03630	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H2515_RS03635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H2515_RS03640	COG0149	triose-phosphate isomerase activity
H2515_RS03655	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2515_RS03660	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2515_RS03665	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2515_RS03670	COG0649	NAD binding
H2515_RS03675	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H2515_RS03680	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H2515_RS03685	COG1034	ATP synthesis coupled electron transport
H2515_RS03690	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H2515_RS03695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2515_RS03705	COG0713	ATP synthesis coupled electron transport
H2515_RS03720	COG1007	ATP synthesis coupled electron transport
H2515_RS03735	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H2515_RS03740	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H2515_RS03745	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H2515_RS03750	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H2515_RS03755	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H2515_RS03760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2515_RS03760	COG0072	phenylalanine-tRNA ligase activity
H2515_RS03765	COG0776	regulation of translation
H2515_RS03815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H2515_RS03835	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H2515_RS03840	COG2154	pterin-4-alpha-carbinolamine dehydratase
H2515_RS03865	COG0204	Acyl-transferase
H2515_RS03870	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H2515_RS03875	COG0751	glycine-tRNA ligase activity
H2515_RS03920	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H2515_RS03925	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H2515_RS03930	COG0321	lipoyl(octanoyl) transferase activity
H2515_RS03940	COG1686	Belongs to the peptidase S11 family
H2515_RS03945	COG0772	Belongs to the SEDS family
H2515_RS03960	COG1792	Involved in formation and maintenance of cell shape
H2515_RS03965	COG1077	Cell shape determining protein MreB Mrl
H2515_RS03970	COG0737	Belongs to the 5'-nucleotidase family
H2515_RS03975	COG3439	Domain of unknown function DUF302
H2515_RS04000	COG3852	Histidine kinase
H2515_RS04010	COG0315	cyclic pyranopterin monophosphate synthase activity
H2515_RS04020	COG0243	molybdopterin cofactor binding
H2515_RS04025	COG0437	4 iron, 4 sulfur cluster binding
H2515_RS04035	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H2515_RS04040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H2515_RS04045	COG0425	Belongs to the sulfur carrier protein TusA family
H2515_RS04050	COG2210	Belongs to the sulfur carrier protein TusA family
H2515_RS04080	COG2048	Heterodisulfide reductase, subunit B
H2515_RS04085	COG0509	glycine decarboxylation via glycine cleavage system
H2515_RS04095	COG0509	glycine decarboxylation via glycine cleavage system
H2515_RS04105	COG0095	Lipoate-protein ligase
H2515_RS04110	COG0644	oxidoreductase
H2515_RS04160	COG0123	including yeast histone deacetylase and acetoin utilization protein
H2515_RS04175	COG0583	DNA-binding transcription factor activity
H2515_RS04190	COG0586	Pfam SNARE associated Golgi protein
H2515_RS04195	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H2515_RS04210	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H2515_RS04230	COG0791	NLP P60 protein
H2515_RS04250	COG1199	ATP-dependent helicase activity
H2515_RS04285	COG2960	long-chain fatty acid transporting porin activity
H2515_RS04290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2515_RS04295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2515_RS04300	COG0084	hydrolase, TatD family'
H2515_RS04305	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H2515_RS04320	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H2515_RS04330	COG0640	Transcriptional regulator
H2515_RS04340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2515_RS04360	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H2515_RS04370	COG0860	N-Acetylmuramoyl-L-alanine amidase
H2515_RS04375	COG1272	protein, Hemolysin III
H2515_RS04385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2515_RS04395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H2515_RS04400	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H2515_RS04405	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H2515_RS04405	COG0047	phosphoribosylformylglycinamidine synthase activity
H2515_RS04415	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
H2515_RS04430	COG4691	Plasmid stability protein
H2515_RS04460	COG1686	Belongs to the peptidase S11 family
H2515_RS04480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H2515_RS04495	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H2515_RS04500	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H2515_RS04505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H2515_RS04510	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H2515_RS04520	COG1193	negative regulation of DNA recombination
H2515_RS04545	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H2515_RS04550	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H2515_RS04560	COG0243	molybdopterin cofactor binding
H2515_RS04590	COG0529	Catalyzes the synthesis of activated sulfate
H2515_RS04590	COG2046	Belongs to the sulfate adenylyltransferase family
H2515_RS04595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H2515_RS04610	COG0459	protein refolding
H2515_RS04615	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H2515_RS04625	COG4232	protein-disulfide reductase activity
H2515_RS04640	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H2515_RS04650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H2515_RS04660	COG4178	(ABC) transporter
H2515_RS04680	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H2515_RS04685	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H2515_RS04690	COG0196	riboflavin kinase activity
H2515_RS04705	COG1538	Outer membrane efflux protein
H2515_RS04775	COG4974	Belongs to the 'phage' integrase family
H2515_RS04790	COG2197	response regulator
H2515_RS04820	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2515_RS04840	COG1942	4-Oxalocrotonate Tautomerase
H2515_RS04860	COG4319	ketosteroid isomerase
H2515_RS04900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H2515_RS04915	COG1846	Transcriptional regulator
H2515_RS04925	COG2353	YceI-like domain
H2515_RS04975	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
H2515_RS05005	COG5377	YqaJ viral recombinase family
H2515_RS05035	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
H2515_RS05045	COG0671	phosphoesterase, PA-phosphatase related
H2515_RS05065	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
H2515_RS05105	COG1484	DNA-dependent DNA replication
H2515_RS05150	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H2515_RS05150	COG1672	PFAM Archaeal ATPase
H2515_RS05265	COG0631	protein serine/threonine phosphatase activity
H2515_RS05375	COG0776	regulation of translation
H2515_RS05380	COG0842	Transport permease protein
H2515_RS05385	COG0842	Transport permease protein
H2515_RS05390	COG1131	(ABC) transporter
H2515_RS05400	COG1850	ribulose-bisphosphate carboxylase activity
H2515_RS05430	COG1561	YicC-like family, N-terminal region
H2515_RS05435	COG0194	GDP metabolic process
H2515_RS05440	COG1758	RNA polymerase activity
H2515_RS05445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H2515_RS05475	COG0628	permease
H2515_RS05500	COG1355	regulation of microtubule-based process
H2515_RS05505	COG2078	PFAM AMMECR1 domain protein
H2515_RS05520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H2515_RS05525	COG0303	'Molybdopterin
H2515_RS05530	COG1763	Mo-molybdopterin cofactor biosynthetic process
H2515_RS05535	COG0746	molybdenum cofactor guanylyltransferase activity
H2515_RS05550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H2515_RS05565	COG0135	phosphoribosylanthranilate isomerase activity
H2515_RS05570	COG0133	tryptophan synthase activity
H2515_RS05575	COG0159	tryptophan synthase activity
H2515_RS05580	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H2515_RS05585	COG0285	dihydrofolate synthase activity
H2515_RS05595	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H2515_RS05610	COG1253	flavin adenine dinucleotide binding
H2515_RS05615	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H2515_RS05620	COG0343	queuine tRNA-ribosyltransferase activity
H2515_RS05625	COG1862	Preprotein translocase
H2515_RS05630	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H2515_RS05690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H2515_RS05720	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H2515_RS05725	COG0493	'glutamate synthase
H2515_RS05730	COG0069	glutamate synthase activity
H2515_RS05730	COG0067	glutamate synthase
H2515_RS05730	COG0070	glutamate synthase
H2515_RS05735	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H2515_RS05740	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
H2515_RS05745	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H2515_RS05750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H2515_RS05785	COG0432	Pfam Uncharacterised protein family UPF0047
H2515_RS05795	COG1193	negative regulation of DNA recombination
H2515_RS05800	COG0028	Belongs to the TPP enzyme family
H2515_RS05810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H2515_RS05815	COG0688	phosphatidylethanolamine metabolic process
H2515_RS05820	COG1183	phosphatidylcholine synthase activity
H2515_RS05830	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2515_RS05915	COG0642	Histidine kinase
H2515_RS05930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2515_RS05940	COG0187	DNA topoisomerase II activity
H2515_RS05955	COG0741	lytic transglycosylase activity
H2515_RS05960	COG1741	Belongs to the pirin family
H2515_RS05975	COG0243	molybdopterin cofactor binding
H2515_RS05990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2515_RS06020	COG3707	response regulator
H2515_RS06030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H2515_RS06030	COG1648	precorrin-2 dehydrogenase activity
H2515_RS06035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H2515_RS06040	COG0243	molybdopterin cofactor binding
H2515_RS06045	COG2146	nitrite reductase [NAD(P)H] activity
H2515_RS06050	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2515_RS06060	COG2223	nitrite transmembrane transporter activity
H2515_RS06065	COG1116	anion transmembrane transporter activity
H2515_RS06065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2515_RS06075	COG3189	MarR family transcriptional regulator
H2515_RS06080	COG0509	glycine decarboxylation via glycine cleavage system
H2515_RS06105	COG1566	PFAM secretion protein HlyD family protein
H2515_RS06120	COG0583	DNA-binding transcription factor activity
H2515_RS06155	COG0670	Belongs to the BI1 family
H2515_RS06170	COG1193	negative regulation of DNA recombination
H2515_RS06180	COG0277	FAD linked oxidase domain protein
H2515_RS06185	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H2515_RS06190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H2515_RS06195	COG1428	Deoxynucleoside kinase
H2515_RS06200	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H2515_RS06205	COG0617	tRNA 3'-terminal CCA addition
H2515_RS06205	COG3620	sequence-specific DNA binding
H2515_RS06205	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H2515_RS06215	COG0463	Glycosyl transferase, family 2
H2515_RS06225	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H2515_RS06225	COG0519	Catalyzes the synthesis of GMP from XMP
H2515_RS06230	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H2515_RS06235	COG3264	Mechanosensitive ion channel
H2515_RS06235	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H2515_RS06255	COG0009	L-threonylcarbamoyladenylate synthase
H2515_RS06260	COG1994	Peptidase M50
H2515_RS06265	COG0180	Tryptophanyl-tRNA synthetase
H2515_RS06270	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H2515_RS06275	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H2515_RS06280	COG0446	pyridine nucleotide-disulphide oxidoreductase
H2515_RS06285	COG1187	pseudouridine synthase activity
H2515_RS06315	COG1215	transferase activity, transferring glycosyl groups
H2515_RS06325	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H2515_RS06340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H2515_RS06355	COG0446	pyridine nucleotide-disulphide oxidoreductase
H2515_RS06365	COG1105	Belongs to the carbohydrate kinase PfkB family
H2515_RS06370	COG0280	phosphate acetyltransferase
H2515_RS06375	COG0477	Major facilitator Superfamily
H2515_RS06380	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H2515_RS06385	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2515_RS06390	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H2515_RS06395	COG0574	Belongs to the PEP-utilizing enzyme family
H2515_RS06395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H2515_RS06410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H2515_RS06415	COG2171	N-acyltransferase activity
H2515_RS06420	COG0436	Aminotransferase
H2515_RS06430	COG0811	peptide transport
H2515_RS06435	COG0848	biopolymer transport protein
H2515_RS06455	COG0440	acetolactate synthase activity
H2515_RS06460	COG0039	L-malate dehydrogenase activity
H2515_RS06470	COG4166	transmembrane transport
H2515_RS06475	COG0601	transmembrane transport
H2515_RS06480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2515_RS06485	COG0444	Belongs to the ABC transporter superfamily
H2515_RS06520	COG1132	(ABC) transporter
H2515_RS06535	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H2515_RS06540	COG0402	S-adenosylhomocysteine deaminase activity
H2515_RS06550	COG0791	NLP P60 protein
H2515_RS06550	COG0741	lytic transglycosylase activity
H2515_RS06560	COG2363	Small membrane protein
H2515_RS06585	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H2515_RS06590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H2515_RS06615	COG0109	protoheme IX farnesyltransferase activity
H2515_RS06620	COG2814	Major facilitator Superfamily
H2515_RS06635	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H2515_RS06660	COG1333	cytochrome c biogenesis protein
H2515_RS06695	COG2915	High frequency lysogenization protein hflD homolog
H2515_RS06700	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H2515_RS06705	COG0024	Methionine aminopeptidase
H2515_RS06710	COG1489	DNA binding
H2515_RS06715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H2515_RS06725	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H2515_RS06730	COG1546	Belongs to the CinA family
H2515_RS06730	COG1058	Belongs to the CinA family
H2515_RS06735	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H2515_RS06740	COG2137	regulation of response to DNA damage stimulus
H2515_RS06765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H2515_RS06780	COG0488	(ABC) transporter
H2515_RS06820	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H2515_RS06825	COG2204	response regulator
H2515_RS06840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2515_RS06855	COG3416	Protein conserved in bacteria
H2515_RS06855	COG2943	transferase activity, transferring hexosyl groups
H2515_RS06870	COG2363	Small membrane protein
H2515_RS06880	COG0616	signal peptide processing
H2515_RS06885	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H2515_RS06890	COG0314	molybdopterin synthase activity
H2515_RS06895	COG1666	GTP binding
H2515_RS06900	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H2515_RS06910	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H2515_RS06915	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H2515_RS06920	COG0714	Associated with various cellular activities
H2515_RS06935	COG1132	(ABC) transporter
H2515_RS06940	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H2515_RS06945	COG0450	alkyl hydroperoxide reductase
H2515_RS06955	COG0613	PHP domain protein
H2515_RS06960	COG0628	permease
H2515_RS06980	COG0084	hydrolase, TatD family'
H2515_RS06985	COG0321	lipoyl(octanoyl) transferase activity
H2515_RS06985	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H2515_RS07015	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H2515_RS07030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2515_RS07035	COG0481	GTPase activity
H2515_RS07040	COG0681	Belongs to the peptidase S26 family
H2515_RS07050	COG0571	ribonuclease III activity
H2515_RS07055	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H2515_RS07060	COG1381	Involved in DNA repair and RecF pathway recombination
H2515_RS07065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H2515_RS07070	COG0736	holo-[acyl-carrier-protein] synthase activity
H2515_RS07080	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H2515_RS07080	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H2515_RS07085	COG0037	tRNA processing
H2515_RS07090	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H2515_RS07140	COG0729	surface antigen
H2515_RS07145	COG2911	Protein conserved in bacteria
H2515_RS07175	COG0542	response to heat
H2515_RS07195	COG4584	PFAM Integrase catalytic
H2515_RS07240	COG1518	maintenance of DNA repeat elements
H2515_RS07280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2515_RS07290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H2515_RS07295	COG0438	transferase activity, transferring glycosyl groups
H2515_RS07310	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H2515_RS07315	COG1469	GTP cyclohydrolase I activity
H2515_RS07320	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H2515_RS07325	COG0142	geranyltranstransferase activity
H2515_RS07330	COG1722	exodeoxyribonuclease VII activity
H2515_RS07335	COG2223	nitrite transmembrane transporter activity
H2515_RS07345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2515_RS07350	COG1570	exodeoxyribonuclease VII activity
H2515_RS07360	COG0531	amino acid
H2515_RS07365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H2515_RS07370	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H2515_RS07375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H2515_RS07395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H2515_RS07410	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H2515_RS07415	COG1846	Transcriptional regulator
H2515_RS07420	COG2814	Major facilitator Superfamily
H2515_RS07440	COG1846	Transcriptional regulator
H2515_RS07495	COG0300	oxidoreductase activity
H2515_RS07510	COG4974	Belongs to the 'phage' integrase family
H2515_RS07525	COG2353	YceI-like domain
H2515_RS07550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H2515_RS07565	COG5654	RES domain protein
H2515_RS07570	COG0438	transferase activity, transferring glycosyl groups
H2515_RS07575	COG0438	transferase activity, transferring glycosyl groups
H2515_RS07600	COG1012	belongs to the aldehyde dehydrogenase family
H2515_RS07625	COG0633	Ferredoxin
H2515_RS07630	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H2515_RS07640	COG5554	nitrogen fixation
H2515_RS07645	COG1104	cysteine desulfurase activity
H2515_RS07675	COG0316	Belongs to the HesB IscA family
H2515_RS07680	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H2515_RS07710	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
H2515_RS07720	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H2515_RS07735	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H2515_RS07740	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H2515_RS07755	COG5420	small protein containing a coiled-coil domain
H2515_RS07855	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H2515_RS07890	COG1166	arginine decarboxylase activity
H2515_RS07895	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H2515_RS07900	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H2515_RS07920	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H2515_RS07925	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H2515_RS07935	COG1196	nuclear chromosome segregation
H2515_RS07940	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H2515_RS07975	COG1215	transferase activity, transferring glycosyl groups
H2515_RS07980	COG1215	transferase activity, transferring glycosyl groups
H2515_RS07990	COG0784	Response regulator, receiver
H2515_RS07990	COG2198	Histidine kinase
H2515_RS07990	COG2205	protein histidine kinase activity
H2515_RS07995	COG1024	Enoyl-CoA hydratase
H2515_RS08005	COG0457	Tetratricopeptide repeat
H2515_RS08005	COG3118	belongs to the thioredoxin family
H2515_RS08010	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H2515_RS08070	COG0326	Molecular chaperone. Has ATPase activity
H2515_RS08220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H2515_RS08235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H2515_RS08290	COG1160	GTP binding
H2515_RS08305	COG0124	histidyl-tRNA synthetase
H2515_RS08310	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H2515_RS08315	COG1426	Protein conserved in bacteria
H2515_RS08325	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H2515_RS08330	COG0105	UTP biosynthetic process
H2515_RS08335	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H2515_RS08340	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H2515_RS08345	COG0802	atpase or kinase
H2515_RS08355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H2515_RS08360	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H2515_RS08360	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H2515_RS08365	COG0004	ammonium transporteR
H2515_RS08370	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H2515_RS08375	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H2515_RS08380	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H2515_RS08405	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H2515_RS08410	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H2515_RS08420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H2515_RS08425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2515_RS08435	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H2515_RS08440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H2515_RS08445	COG0416	fatty acid biosynthetic process
H2515_RS08450	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H2515_RS08460	COG1959	2 iron, 2 sulfur cluster binding
H2515_RS08460	COG1295	ribonuclease BN
H2515_RS08465	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H2515_RS08470	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H2515_RS08480	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H2515_RS08485	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H2515_RS08490	COG1058	Belongs to the CinA family
H2515_RS08490	COG1546	Belongs to the CinA family
H2515_RS08495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2515_RS08500	COG2326	polyphosphate kinase activity
H2515_RS08530	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H2515_RS08535	COG0330	HflC and HflK could
H2515_RS08540	COG0330	HflC and HflK could
H2515_RS08545	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H2515_RS08550	COG1923	regulation of RNA biosynthetic process
H2515_RS08555	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H2515_RS08560	COG0424	maF-like protein
H2515_RS08575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2515_RS08580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2515_RS08585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H2515_RS08600	COG3025	triphosphatase activity
H2515_RS08610	COG0308	aminopeptidase N
H2515_RS08620	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H2515_RS08630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H2515_RS08650	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H2515_RS08655	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H2515_RS08660	COG0740	serine-type endopeptidase activity
H2515_RS08665	COG0544	peptidyl-prolyl cis-trans isomerase activity
H2515_RS08670	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H2515_RS08675	COG0284	orotidine-5'-phosphate decarboxylase activity
H2515_RS08680	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H2515_RS08685	COG0776	regulation of translation
H2515_RS08695	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H2515_RS08700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H2515_RS08710	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H2515_RS08715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H2515_RS08725	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H2515_RS08735	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H2515_RS08740	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H2515_RS08815	COG0439	Biotin carboxylase
H2515_RS08820	COG3665	Urea carboxylase-associated protein
H2515_RS08830	COG1116	anion transmembrane transporter activity
H2515_RS08835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2515_RS08845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H2515_RS08855	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2515_RS08860	COG3657	addiction module killer protein
H2515_RS08890	COG1192	Involved in chromosome partitioning
H2515_RS08895	COG1475	DNA binding
H2515_RS08935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H2515_RS08965	COG0776	regulation of translation
H2515_RS09015	COG3701	Conjugal transfer protein
H2515_RS09025	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2515_RS09075	COG4962	Type ii secretion system protein e
H2515_RS09125	COG3311	Transcriptional regulator
H2515_RS09130	COG1569	PIN domain
H2515_RS09145	COG3077	Addiction module antitoxin, RelB DinJ family
H2515_RS09150	COG3041	Addiction module toxin RelE StbE family
H2515_RS09165	COG0629	single-stranded DNA binding
H2515_RS09180	COG1484	DNA-dependent DNA replication
H2515_RS09195	COG4197	protein conserved in bacteria, prophage-related
H2515_RS09215	COG4974	Belongs to the 'phage' integrase family
H2515_RS09260	COG1132	(ABC) transporter
H2515_RS09265	COG0436	Aminotransferase
H2515_RS09275	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H2515_RS09280	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H2515_RS09310	COG0322	excinuclease ABC activity
H2515_RS09320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H2515_RS09325	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H2515_RS09330	COG0148	phosphopyruvate hydratase activity
H2515_RS09335	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H2515_RS09340	COG0504	CTP synthase activity
H2515_RS09345	COG1064	alcohol dehydrogenase
H2515_RS09415	COG0477	Major facilitator Superfamily
H2515_RS09425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2515_RS09425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H2515_RS09430	COG1230	cation diffusion facilitator family transporter
H2515_RS09475	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H2515_RS09490	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H2515_RS09505	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H2515_RS09515	COG1215	transferase activity, transferring glycosyl groups
H2515_RS09530	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H2515_RS09535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H2515_RS09540	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H2515_RS09545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H2515_RS09550	COG0037	tRNA processing
H2515_RS09555	COG0825	malonyl-CoA metabolic process
H2515_RS09565	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H2515_RS09580	COG0673	inositol 2-dehydrogenase activity
H2515_RS09585	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H2515_RS09590	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H2515_RS09595	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H2515_RS09615	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H2515_RS09620	COG0575	Belongs to the CDS family
H2515_RS09625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H2515_RS09635	COG0528	UMP kinase activity
H2515_RS09640	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H2515_RS09645	COG0052	Belongs to the universal ribosomal protein uS2 family
H2515_RS09665	COG0704	Plays a role in the regulation of phosphate uptake
H2515_RS09670	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H2515_RS09675	COG0581	inorganic phosphate transmembrane transporter activity
H2515_RS09680	COG0573	inorganic phosphate transmembrane transporter activity
H2515_RS09685	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H2515_RS09695	COG0745	RESPONSE REGULATOR receiver
H2515_RS09700	COG0513	Belongs to the DEAD box helicase family
H2515_RS09755	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H2515_RS09760	COG0154	amidase activity
H2515_RS09765	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H2515_RS09780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H2515_RS09795	COG3394	polysaccharide catabolic process
H2515_RS09800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H2515_RS09810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2515_RS09820	COG1657	PFAM Prenyltransferase squalene oxidase
H2515_RS09825	COG1562	ergosterol biosynthetic process
H2515_RS09830	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H2515_RS09835	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H2515_RS09850	COG0442	prolyl-tRNA aminoacylation
H2515_RS09855	COG0589	response to stress
H2515_RS09870	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H2515_RS09890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H2515_RS09910	COG0768	penicillin binding
H2515_RS09915	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H2515_RS09920	COG0193	aminoacyl-tRNA hydrolase activity
H2515_RS09925	COG0012	GTP binding
H2515_RS09930	COG4942	peptidase
H2515_RS09950	COG1396	sequence-specific DNA binding
H2515_RS09955	COG0651	ATP synthesis coupled electron transport
H2515_RS09960	COG0650	Formate hydrogenlyase subunit 4
H2515_RS09970	COG0651	ATP synthesis coupled electron transport
H2515_RS09975	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
H2515_RS09975	COG3261	NADH dehydrogenase
H2515_RS09980	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2515_RS10005	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H2515_RS10010	COG0494	nUDIX hydrolase
H2515_RS10020	COG1187	pseudouridine synthase activity
H2515_RS10035	COG0210	DNA helicase
H2515_RS10040	COG0268	Binds directly to 16S ribosomal RNA
H2515_RS10045	COG3842	ATPase activity
H2515_RS10060	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H2515_RS10065	COG0514	ATP-dependent DNA helicase (RecQ)
H2515_RS10070	COG1965	Belongs to the frataxin family
H2515_RS10095	COG0795	lipopolysaccharide-transporting ATPase activity
H2515_RS10100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H2515_RS10105	COG2927	DNA polymerase III (CHI subunit)
H2515_RS10115	COG0525	valine-tRNA ligase activity
H2515_RS10120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H2515_RS10140	COG0412	Dienelactone hydrolase
H2515_RS10145	COG1902	pentaerythritol trinitrate reductase activity
H2515_RS10170	COG0671	phosphoesterase, PA-phosphatase related
H2515_RS10175	COG1596	polysaccharide export
H2515_RS10180	COG3206	protein involved in exopolysaccharide biosynthesis
H2515_RS10180	COG0489	protein tyrosine kinase activity
H2515_RS10195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H2515_RS10240	COG0110	maltose O-acetyltransferase activity
H2515_RS10245	COG0297	glycogen (starch) synthase activity
H2515_RS10250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2515_RS10265	COG0662	Cupin 2, conserved barrel domain protein
H2515_RS10265	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H2515_RS10285	COG0297	glycogen (starch) synthase activity
H2515_RS10305	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H2515_RS10315	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H2515_RS10330	COG3657	addiction module killer protein
H2515_RS10345	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
H2515_RS10355	COG2917	probably involved in intracellular septation
H2515_RS10360	COG2350	Protein conserved in bacteria
H2515_RS10365	COG0271	Belongs to the BolA IbaG family
H2515_RS10370	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H2515_RS10370	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H2515_RS10380	COG0129	dihydroxy-acid dehydratase activity
H2515_RS10385	COG0628	permease
H2515_RS10390	COG0281	malic enzyme
H2515_RS10395	COG0254	rRNA binding
H2515_RS10415	COG1136	(ABC) transporter
H2515_RS10420	COG0577	efflux transmembrane transporter activity
H2515_RS10435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H2515_RS10455	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H2515_RS10460	COG1127	ABC transporter
H2515_RS10465	COG0163	prenyltransferase activity
H2515_RS10470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H2515_RS10480	COG2022	thiamine diphosphate biosynthetic process
H2515_RS10490	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H2515_RS10530	COG1752	Esterase of the alpha-beta hydrolase superfamily
H2515_RS10535	COG0482	sulfurtransferase activity
H2515_RS10550	COG0443	Heat shock 70 kDa protein
H2515_RS10555	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H2515_RS10565	COG0822	iron-sulfur transferase activity
H2515_RS10570	COG1104	cysteine desulfurase activity
H2515_RS10575	COG1959	2 iron, 2 sulfur cluster binding
H2515_RS10585	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H2515_RS10595	COG3300	MHYT domain
H2515_RS10595	COG5001	Diguanylate cyclase
H2515_RS10610	COG1530	ribonuclease E activity
H2515_RS10615	COG0215	cysteine-tRNA ligase activity
H2515_RS10620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H2515_RS10640	COG0531	amino acid
H2515_RS10660	COG0745	RESPONSE REGULATOR receiver
H2515_RS10665	COG2205	protein histidine kinase activity
H2515_RS10675	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H2515_RS10685	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H2515_RS10700	COG0138	bifunctional purine biosynthesis protein purh
H2515_RS10705	COG0151	Belongs to the GarS family
H2515_RS10710	COG0009	L-threonylcarbamoyladenylate synthase
H2515_RS10715	COG0408	coproporphyrinogen oxidase activity
H2515_RS10720	COG0167	dihydroorotate dehydrogenase activity
H2515_RS10750	COG0811	peptide transport
H2515_RS10780	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H2515_RS10785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2515_RS10805	COG0033	Phosphoglucomutase
H2515_RS10820	COG4974	Belongs to the 'phage' integrase family
H2515_RS10900	COG3451	type IV secretory pathway VirB4
H2515_RS10925	COG1484	DNA-dependent DNA replication
H2515_RS11005	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2515_RS11040	COG0697	spore germination
H2515_RS11045	COG0681	Belongs to the peptidase S26 family
H2515_RS11080	COG1475	DNA binding
H2515_RS11085	COG1192	Involved in chromosome partitioning
H2515_RS11115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H2515_RS11125	COG2948	multi-organism process
H2515_RS11135	COG3701	Conjugal transfer protein
H2515_RS11170	COG3451	type IV secretory pathway VirB4
H2515_RS11190	COG4962	Type ii secretion system protein e
H2515_RS11335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H2515_RS11355	COG4372	Transposase
H2515_RS11395	COG3437	response regulator, receiver
H2515_RS11400	COG0784	Response regulator, receiver
H2515_RS11420	COG0776	regulation of translation
H2515_RS11425	COG0776	regulation of translation
H2515_RS11440	COG2226	methyltransferase
H2515_RS11445	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H2515_RS11460	COG1815	bacterial-type flagellum-dependent cell motility
H2515_RS11470	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H2515_RS11475	COG1749	Flagellar hook protein flgE
H2515_RS11495	COG1706	bacterial-type flagellum-dependent cell motility
H2515_RS11500	COG3951	Flagellar rod assembly protein muramidase FlgJ
H2515_RS11500	COG1705	Flagellar rod assembly protein muramidase FlgJ
H2515_RS11505	COG1256	bacterial-type flagellum assembly
H2515_RS11545	COG1677	Flagellar hook-basal body complex protein FliE
H2515_RS11585	COG1191	sigma factor activity
H2515_RS11620	COG1987	bacterial-type flagellum assembly
H2515_RS11630	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H2515_RS11635	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H2515_RS11665	COG0643	Histidine kinase
H2515_RS11665	COG2198	Histidine kinase
H2515_RS11685	COG0835	chemotaxis
H2515_RS11685	COG0784	Response regulator, receiver
H2515_RS11690	COG0840	transmembrane signaling receptor activity
H2515_RS11715	COG1845	cytochrome c oxidase, subunit III
H2515_RS11720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H2515_RS11740	COG0505	Belongs to the CarA family
H2515_RS11750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H2515_RS11755	COG1968	undecaprenyl-diphosphatase activity
H2515_RS11760	COG0109	protoheme IX farnesyltransferase activity
H2515_RS11780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H2515_RS11785	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H2515_RS11800	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H2515_RS11805	COG0259	pyridoxamine-phosphate oxidase activity
H2515_RS11815	COG0066	3-isopropylmalate dehydratase activity
H2515_RS11820	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H2515_RS11825	COG2226	methyltransferase
H2515_RS11840	COG0406	alpha-ribazole phosphatase activity
H2515_RS11850	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H2515_RS11855	COG1132	(ABC) transporter
H2515_RS11860	COG0438	transferase activity, transferring glycosyl groups
H2515_RS11865	COG0438	transferase activity, transferring glycosyl groups
H2515_RS11870	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H2515_RS11910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H2515_RS11920	COG1121	(ABC) transporter
H2515_RS11930	COG0312	modulator of DNA gyrase
H2515_RS11935	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H2515_RS11940	COG4535	Mg2 and Co2 transporter CorC
H2515_RS11945	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H2515_RS11950	COG1702	phosphate starvation-inducible protein PhoH
H2515_RS11955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H2515_RS11965	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H2515_RS11975	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H2515_RS11980	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H2515_RS11985	COG1278	Cold shock
H2515_RS12015	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H2515_RS12020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H2515_RS12030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2515_RS12035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H2515_RS12045	COG0058	SHG alpha-glucan phosphorylase activity
H2515_RS12050	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H2515_RS12060	COG0793	Belongs to the peptidase S41A family
H2515_RS12065	COG0693	protein deglycase activity
H2515_RS12070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H2515_RS12075	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H2515_RS12080	COG0542	response to heat
H2515_RS12085	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H2515_RS12090	COG1573	uracil-dna glycosylase
H2515_RS12100	COG4453	Protein conserved in bacteria
H2515_RS12115	COG3344	reverse transcriptase
H2515_RS12145	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H2515_RS12150	COG2835	tetraacyldisaccharide 4'-kinase activity
H2515_RS12155	COG1663	tetraacyldisaccharide 4'-kinase activity
H2515_RS12170	COG0848	biopolymer transport protein
H2515_RS12175	COG0811	peptide transport
H2515_RS12180	COG2333	competence protein COMEC
H2515_RS12180	COG0658	competence protein
H2515_RS12190	COG1136	(ABC) transporter
H2515_RS12200	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H2515_RS12220	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H2515_RS12230	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H2515_RS12240	COG0436	Aminotransferase
H2515_RS12255	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H2515_RS12260	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H2515_RS12285	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H2515_RS12290	COG0659	secondary active sulfate transmembrane transporter activity
H2515_RS12295	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H2515_RS12310	COG2161	toxin-antitoxin pair type II binding
H2515_RS12320	COG0495	leucyl-tRNA aminoacylation
H2515_RS12330	COG1466	dna polymerase III delta subunit
H2515_RS12335	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H2515_RS12340	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H2515_RS12340	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H2515_RS12345	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H2515_RS12350	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H2515_RS12355	COG0497	DNA recombination
H2515_RS12360	COG2205	protein histidine kinase activity
H2515_RS12370	COG2204	response regulator
H2515_RS12380	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H2515_RS12405	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H2515_RS12435	COG0732	type I restriction modification DNA specificity domain
H2515_RS12525	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H2515_RS12530	COG0295	cytidine deaminase activity
H2515_RS12540	COG1953	Uracil, thiamine, allantoin
H2515_RS12555	COG0493	'glutamate synthase
H2515_RS12565	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H2515_RS12570	COG1396	sequence-specific DNA binding
H2515_RS12570	COG1917	Cupin 2, conserved barrel domain protein
H2515_RS12580	COG0583	DNA-binding transcription factor activity
H2515_RS12590	COG0746	molybdenum cofactor guanylyltransferase activity
H2515_RS12610	COG3608	succinylglutamate desuccinylase aspartoacylase
H2515_RS12610	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H2515_RS12635	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H2515_RS12645	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H2515_RS12650	COG0402	S-adenosylhomocysteine deaminase activity
H2515_RS12665	COG0848	biopolymer transport protein
H2515_RS12670	COG0811	peptide transport
H2515_RS12680	COG0242	peptide deformylase activity
H2515_RS12690	COG0235	Class ii aldolase
H2515_RS12695	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
H2515_RS12700	COG1850	ribulose-bisphosphate carboxylase activity
H2515_RS12705	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H2515_RS12725	COG0347	Belongs to the P(II) protein family
H2515_RS12730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H2515_RS12730	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H2515_RS12735	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H2515_RS12745	COG0045	succinate-CoA ligase (ADP-forming) activity
H2515_RS12750	COG0538	isocitrate dehydrogenase activity
H2515_RS12755	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H2515_RS12760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H2515_RS12765	COG0741	lytic transglycosylase activity
H2515_RS12765	COG1388	LysM domain
H2515_RS12775	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H2515_RS12780	COG0583	DNA-binding transcription factor activity
H2515_RS12795	COG2863	cytochrome
H2515_RS12800	COG1028	Short-chain dehydrogenase reductase Sdr
H2515_RS12805	COG0723	plastoquinol--plastocyanin reductase activity
H2515_RS12810	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H2515_RS12830	COG1640	4-alpha-glucanotransferase
H2515_RS12835	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H2515_RS12845	COG0366	Alpha amylase catalytic
H2515_RS12865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H2515_RS12890	COG0717	Belongs to the dCTP deaminase family
H2515_RS12895	COG0489	protein tyrosine kinase activity
H2515_RS12905	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H2515_RS12910	COG0484	heat shock protein binding
H2515_RS12915	COG0443	Heat shock 70 kDa protein
H2515_RS12920	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H2515_RS12925	COG1420	regulation of RNA biosynthetic process
H2515_RS12930	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H2515_RS12935	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H2515_RS12940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2515_RS12940	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2515_RS12945	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H2515_RS12950	COG0114	fumarate hydratase activity
H2515_RS12975	COG0297	glycogen (starch) synthase activity
H2515_RS12980	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H2515_RS12990	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H2515_RS13015	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H2515_RS13020	COG0633	Ferredoxin
H2515_RS13020	COG0543	2 iron, 2 sulfur cluster binding
H2515_RS13025	COG1151	hydroxylamine reductase activity
H2515_RS13130	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2515_RS13185	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H2515_RS13190	COG1534	Rna-binding protein
H2515_RS13195	COG2967	ApaG domain
H2515_RS13200	COG2226	methyltransferase
H2515_RS13220	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H2515_RS13235	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H2515_RS13240	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H2515_RS13245	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H2515_RS13260	COG2177	Part of the ABC transporter FtsEX involved in
H2515_RS13265	COG2884	Cell division ATP-binding protein ftsE
H2515_RS13270	COG0552	protein localization to endoplasmic reticulum
H2515_RS13275	COG0742	ribosomal rna small subunit methyltransferase
H2515_RS13280	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H2515_RS13285	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H2515_RS13290	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H2515_RS13295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H2515_RS13300	COG2890	protein-(glutamine-N5) methyltransferase activity
H2515_RS13305	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H2515_RS13310	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H2515_RS13325	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H2515_RS13335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H2515_RS13395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2515_RS13525	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2515_RS13545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2515_RS13555	COG3657	addiction module killer protein
H2515_RS13560	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2515_RS13580	COG3300	MHYT domain
H2515_RS13580	COG5001	Diguanylate cyclase
H2515_RS13640	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H2515_RS13655	COG0006	proline dipeptidase activity
H2515_RS13670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H2515_RS13675	COG0305	Participates in initiation and elongation during chromosome replication
H2515_RS13680	COG0359	binds to the 23S rRNA
H2515_RS13695	COG0360	Binds together with S18 to 16S ribosomal RNA
H2515_RS13700	COG1472	Belongs to the glycosyl hydrolase 3 family
H2515_RS13705	COG0531	amino acid
H2515_RS13715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H2515_RS13740	COG0363	glucosamine-6-phosphate deaminase activity
H2515_RS13755	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H2515_RS13760	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H2515_RS13770	COG1449	Belongs to the glycosyl hydrolase 57 family
H2515_RS13775	COG1940	carbohydrate kinase activity
H2515_RS13780	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H2515_RS13785	COG2733	membrane
H2515_RS13795	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H2515_RS13810	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H2515_RS13815	COG0629	single-stranded DNA binding
H2515_RS13830	COG3118	belongs to the thioredoxin family
H2515_RS13835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2515_RS13850	COG0335	large ribosomal subunit rRNA binding
H2515_RS13855	COG0336	Belongs to the RNA methyltransferase TrmD family
H2515_RS13865	COG0228	four-way junction DNA binding
H2515_RS13870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H2515_RS13920	COG1872	DUF167
H2515_RS13925	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H2515_RS13935	COG1566	PFAM secretion protein HlyD family protein
H2515_RS13940	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H2515_RS13945	COG1309	transcriptional regulator
H2515_RS13965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2515_RS13965	COG0543	2 iron, 2 sulfur cluster binding
H2515_RS13970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H2515_RS13975	COG0390	transport system, permease component
H2515_RS13980	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H2515_RS13985	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H2515_RS13995	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H2515_RS14000	COG2226	methyltransferase
H2515_RS14005	COG0596	Alpha beta hydrolase
H2515_RS14010	COG0156	8-amino-7-oxononanoate synthase activity
H2515_RS14015	COG1040	competence protein
H2515_RS14020	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H2515_RS14025	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H2515_RS14030	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H2515_RS14035	COG1560	Kdo2-lipid A biosynthetic process
H2515_RS14040	COG1519	Transferase
H2515_RS14070	COG4636	protein conserved in cyanobacteria
H2515_RS14075	COG0438	transferase activity, transferring glycosyl groups
H2515_RS14080	COG0726	polysaccharide deacetylase
H2515_RS14085	COG0463	Glycosyl transferase, family 2
H2515_RS14090	COG0494	nUDIX hydrolase
H2515_RS14095	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H2515_RS14100	COG0653	protein targeting
H2515_RS14110	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H2515_RS14115	COG0625	glutathione transferase activity
H2515_RS14120	COG1022	Amp-dependent synthetase and ligase
H2515_RS14125	COG0617	tRNA 3'-terminal CCA addition
H2515_RS14140	COG2001	Belongs to the MraZ family
H2515_RS14145	COG0275	rRNA processing
H2515_RS14160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H2515_RS14165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H2515_RS14170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H2515_RS14175	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H2515_RS14180	COG0772	Belongs to the SEDS family
H2515_RS14185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H2515_RS14190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H2515_RS14195	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H2515_RS14200	COG1181	Belongs to the D-alanine--D-alanine ligase family
H2515_RS14215	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H2515_RS14230	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H2515_RS14235	COG0511	ligase activity, forming carbon-carbon bonds
H2515_RS14240	COG0439	Biotin carboxylase
H2515_RS14245	COG2264	protein methyltransferase activity
H2515_RS14255	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H2515_RS14260	COG0741	lytic transglycosylase activity
H2515_RS14260	COG0739	heme binding
H2515_RS14260	COG1196	nuclear chromosome segregation
H2515_RS14265	COG2969	positive regulation of protein catabolic process
H2515_RS14305	COG0475	glutathione-regulated potassium exporter activity
H2515_RS14310	COG1028	Short-chain dehydrogenase reductase Sdr
H2515_RS14325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H2515_RS14370	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H2515_RS14375	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H2515_RS14380	COG0237	dephospho-CoA kinase activity
H2515_RS14400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H2515_RS14405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H2515_RS14410	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H2515_RS14415	COG1047	Peptidyl-prolyl cis-trans
H2515_RS14420	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H2515_RS14430	COG0625	glutathione transferase activity
H2515_RS14435	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H2515_RS14445	COG0708	Exodeoxyribonuclease III
H2515_RS14455	COG0477	Major facilitator Superfamily
H2515_RS14460	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H2515_RS14460	COG3264	Mechanosensitive ion channel
H2515_RS14465	COG0018	arginyl-trna synthetase
H2515_RS14480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H2515_RS14490	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H2515_RS14495	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H2515_RS14500	COG1131	(ABC) transporter
H2515_RS14515	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H2515_RS14520	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H2515_RS14525	COG1127	ABC transporter
H2515_RS14530	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H2515_RS14535	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H2515_RS14540	COG2062	phosphohistidine phosphatase, SixA
H2515_RS14545	COG2204	response regulator
H2515_RS14555	COG2205	protein histidine kinase activity
H2515_RS14565	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H2515_RS14580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H2515_RS14595	COG1660	Displays ATPase and GTPase activities
H2515_RS14600	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H2515_RS14605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2515_RS14605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2515_RS14605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2515_RS14635	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H2515_RS14660	COG3178	'Phosphotransferase
H2515_RS14665	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H2515_RS14670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H2515_RS14675	COG0842	Transport permease protein
H2515_RS14680	COG0271	Belongs to the BolA IbaG family
H2515_RS14685	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H2515_RS14690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H2515_RS14695	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H2515_RS14700	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H2515_RS14705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H2515_RS14710	COG0131	Imidazoleglycerol-phosphate dehydratase
H2515_RS14715	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H2515_RS14720	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H2515_RS14725	COG0107	imidazoleglycerol-phosphate synthase activity
H2515_RS14730	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H2515_RS14730	COG0140	phosphoribosyl-ATP diphosphatase activity
H2515_RS14735	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H2515_RS14740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H2515_RS14745	COG0805	protein transport
H2515_RS14750	COG0438	transferase activity, transferring glycosyl groups
H2515_RS14760	COG1278	Cold shock
H2515_RS14775	COG3158	transport of potassium into the cell
H2515_RS14795	COG0540	Belongs to the ATCase OTCase family
H2515_RS14800	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H2515_RS14805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H2515_RS14810	COG1678	Uncharacterized ACR, COG1678
H2515_RS14815	COG0189	ligase activity
H2515_RS14830	COG0316	Belongs to the HesB IscA family
H2515_RS14835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2515_RS14840	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2515_RS14840	COG0022	dehydrogenase e1 component
H2515_RS14845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H2515_RS14860	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H2515_RS14865	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H2515_RS14870	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H2515_RS14880	COG0778	Nitroreductase
H2515_RS14885	COG2081	HI0933 family
H2515_RS14920	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H2515_RS14925	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H2515_RS14940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H2515_RS14950	COG1611	Belongs to the LOG family
H2515_RS14960	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H2515_RS14965	COG1555	photosystem II stabilization
H2515_RS14970	COG0210	DNA helicase
H2515_RS14995	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2515_RS15035	COG0583	DNA-binding transcription factor activity
H2515_RS15045	COG0038	chloride channel
H2515_RS15055	COG2814	Major facilitator Superfamily
H2515_RS15070	COG0076	glutamate decarboxylase activity
H2515_RS15075	COG0531	amino acid
H2515_RS15145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H2515_RS15155	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H2515_RS15175	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H2515_RS15190	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H2515_RS15275	COG0038	chloride channel
H2515_RS15315	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2515_RS15335	COG3158	transport of potassium into the cell
H2515_RS15340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2515_RS15360	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2515_RS15380	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H2515_RS15385	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H2515_RS15395	COG0651	ATP synthesis coupled electron transport
H2515_RS15400	COG3260	NADH ubiquinone oxidoreductase 20
H2515_RS15405	COG3261	NADH dehydrogenase
H2515_RS15405	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
H2515_RS15410	COG0651	ATP synthesis coupled electron transport
H2515_RS15420	COG0650	Formate hydrogenlyase subunit 4
H2515_RS15450	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H2515_RS15465	COG0148	phosphopyruvate hydratase activity
H2515_RS15470	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H2515_RS15505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H2515_RS15520	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H2515_RS15525	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H2515_RS15530	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H2515_RS15535	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H2515_RS15545	COG0356	it plays a direct role in the translocation of protons across the membrane
H2515_RS15555	COG1475	DNA binding
H2515_RS15565	COG0357	Ribosomal RNA small subunit methyltransferase G
H2515_RS15570	COG0445	tRNA wobble uridine modification
H2515_RS15585	COG0521	Mo-molybdopterin cofactor biosynthetic process
H2515_RS15615	COG0247	lactate metabolic process
H2515_RS15620	COG0277	FAD linked oxidase domain protein
H2515_RS15625	COG0277	FAD linked oxidase domain protein
H2515_RS15675	COG4974	Belongs to the 'phage' integrase family
H2515_RS15695	COG1216	Glycosyl transferase, family 2
H2515_RS15735	COG1088	dTDP-glucose 4,6-dehydratase activity
H2515_RS15740	COG1091	dTDP-4-dehydrorhamnose reductase activity
H2515_RS15750	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H2515_RS15755	COG0477	Major facilitator Superfamily
H2515_RS15765	COG0113	porphobilinogen synthase activity
H2515_RS15775	COG0181	hydroxymethylbilane synthase activity
H2515_RS15785	COG0537	adenosine 5'-monophosphoramidase activity
H2515_RS15790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H2515_RS15795	COG0352	thiamine-phosphate diphosphorylase activity
H2515_RS15800	COG0351	phosphomethylpyrimidine kinase
H2515_RS15820	COG2857	Cytochrome c1
H2515_RS15825	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H2515_RS15830	COG0723	plastoquinol--plastocyanin reductase activity
H2515_RS15835	COG1028	Short-chain dehydrogenase reductase Sdr
H2515_RS15850	COG3154	lipid carrier protein
H2515_RS15855	COG0826	peptidase U32
H2515_RS15860	COG0826	peptidase U32
H2515_RS15880	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H2515_RS15880	COG1328	CTP reductase activity