locus-tag	class	description
AFE_RS00005	COG0592	DNA-directed DNA polymerase activity
AFE_RS00010	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AFE_RS00015	COG0187	DNA topoisomerase II activity
AFE_RS00020	COG0543	2 iron, 2 sulfur cluster binding
AFE_RS00020	COG0493	'glutamate synthase
AFE_RS00045	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AFE_RS00055	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AFE_RS00065	COG0850	regulation of cytokinetic process
AFE_RS00070	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AFE_RS00080	COG2922	Belongs to the Smg family
AFE_RS00085	COG0758	DNA mediated transformation
AFE_RS00095	COG0242	peptide deformylase activity
AFE_RS00100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AFE_RS00105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AFE_RS00115	COG5000	phosphorelay sensor kinase activity
AFE_RS00120	COG2204	response regulator
AFE_RS00125	COG3852	Histidine kinase
AFE_RS00130	COG2204	response regulator
AFE_RS00135	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AFE_RS00145	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AFE_RS00150	COG0706	membrane insertase activity
AFE_RS00155	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AFE_RS00165	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AFE_RS00170	COG0488	(ABC) transporter
AFE_RS00180	COG1566	PFAM secretion protein HlyD family protein
AFE_RS00260	COG2095	MarC family integral membrane protein
AFE_RS00270	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AFE_RS00275	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AFE_RS00285	COG0217	transcriptional regulatory protein
AFE_RS00290	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AFE_RS00295	COG0632	four-way junction helicase activity
AFE_RS00300	COG2255	four-way junction helicase activity
AFE_RS00305	COG0824	Thioesterase
AFE_RS00325	COG0823	Involved in the tonB-independent uptake of proteins
AFE_RS00330	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AFE_RS00335	COG0602	queuosine metabolic process
AFE_RS00345	COG2885	chlorophyll binding
AFE_RS00375	COG2226	methyltransferase
AFE_RS00405	COG0438	transferase activity, transferring glycosyl groups
AFE_RS00450	COG3177	Filamentation induced by cAMP protein fic
AFE_RS00480	COG1252	NADH dehydrogenase
AFE_RS00495	COG1136	(ABC) transporter
AFE_RS00510	COG1914	H( )-stimulated, divalent metal cation uptake system
AFE_RS00530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFE_RS00575	COG2833	Protein of unknown function (DUF455)
AFE_RS00580	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AFE_RS00590	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AFE_RS00595	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AFE_RS00600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFE_RS00630	COG0583	DNA-binding transcription factor activity
AFE_RS00650	COG0277	FAD linked oxidase domain protein
AFE_RS00655	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AFE_RS00660	COG0792	nuclease activity
AFE_RS00665	COG3107	peptidoglycan biosynthetic process
AFE_RS00690	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AFE_RS00700	COG2363	Small membrane protein
AFE_RS00710	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AFE_RS00720	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AFE_RS00725	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AFE_RS00730	COG1127	ABC transporter
AFE_RS00735	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AFE_RS00740	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AFE_RS00755	COG1131	(ABC) transporter
AFE_RS00760	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AFE_RS00765	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AFE_RS00775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AFE_RS00790	COG0018	arginyl-trna synthetase
AFE_RS00800	COG0583	DNA-binding transcription factor activity
AFE_RS00810	COG0708	Exodeoxyribonuclease III
AFE_RS00820	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AFE_RS00825	COG0625	glutathione transferase activity
AFE_RS00830	COG0708	Exodeoxyribonuclease III
AFE_RS00835	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AFE_RS00840	COG1047	Peptidyl-prolyl cis-trans
AFE_RS00845	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AFE_RS00850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AFE_RS00855	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AFE_RS00870	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AFE_RS00875	COG0237	dephospho-CoA kinase activity
AFE_RS00880	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AFE_RS00885	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AFE_RS00895	COG0741	lytic transglycosylase activity
AFE_RS00895	COG0739	heme binding
AFE_RS00895	COG1196	nuclear chromosome segregation
AFE_RS00900	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AFE_RS00910	COG2264	protein methyltransferase activity
AFE_RS00915	COG0439	Biotin carboxylase
AFE_RS00925	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AFE_RS00940	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AFE_RS00950	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AFE_RS00955	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFE_RS00960	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AFE_RS00965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AFE_RS00970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AFE_RS00975	COG0772	Belongs to the SEDS family
AFE_RS00980	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AFE_RS00985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AFE_RS00990	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AFE_RS00995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AFE_RS01010	COG0275	rRNA processing
AFE_RS01015	COG2001	Belongs to the MraZ family
AFE_RS01020	COG0617	tRNA 3'-terminal CCA addition
AFE_RS01025	COG1022	Amp-dependent synthetase and ligase
AFE_RS01030	COG0625	glutathione transferase activity
AFE_RS01035	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AFE_RS01045	COG0653	protein targeting
AFE_RS01050	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AFE_RS01055	COG0494	nUDIX hydrolase
AFE_RS01060	COG0463	Glycosyl transferase, family 2
AFE_RS01075	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AFE_RS01105	COG1519	Transferase
AFE_RS01110	COG1560	Kdo2-lipid A biosynthetic process
AFE_RS01115	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AFE_RS01120	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AFE_RS01125	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AFE_RS01130	COG1040	competence protein
AFE_RS01135	COG0156	8-amino-7-oxononanoate synthase activity
AFE_RS01140	COG2267	carboxylic ester hydrolase activity
AFE_RS01145	COG2226	methyltransferase
AFE_RS01150	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AFE_RS01155	COG0501	Belongs to the peptidase M48B family
AFE_RS01160	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AFE_RS01165	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AFE_RS01170	COG0390	transport system, permease component
AFE_RS01180	COG0543	2 iron, 2 sulfur cluster binding
AFE_RS01180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFE_RS01200	COG1309	transcriptional regulator
AFE_RS01205	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AFE_RS01210	COG1566	PFAM secretion protein HlyD family protein
AFE_RS01220	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AFE_RS01225	COG1872	DUF167
AFE_RS01275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AFE_RS01280	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AFE_RS01285	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AFE_RS01290	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AFE_RS01305	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AFE_RS01310	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AFE_RS01330	COG0735	belongs to the Fur family
AFE_RS01335	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AFE_RS01340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AFE_RS01345	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AFE_RS01350	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AFE_RS01355	COG0659	secondary active sulfate transmembrane transporter activity
AFE_RS01360	COG0288	reversible hydration of carbon dioxide
AFE_RS01365	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AFE_RS01370	COG2226	methyltransferase
AFE_RS01380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AFE_RS01380	COG2813	Specifically methylates the guanine in position
AFE_RS01385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AFE_RS01395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AFE_RS01400	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AFE_RS01405	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFE_RS01405	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFE_RS01420	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AFE_RS01425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AFE_RS01445	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AFE_RS01470	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AFE_RS01490	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AFE_RS01495	COG0081	regulation of translation
AFE_RS01500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AFE_RS01505	COG0222	ribosome binding
AFE_RS01510	COG0085	RNA polymerase activity
AFE_RS01515	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AFE_RS01520	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AFE_RS01525	COG0049	tRNA binding
AFE_RS01530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AFE_RS01535	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AFE_RS01540	COG0051	transcription antitermination factor activity, RNA binding
AFE_RS01545	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AFE_RS01550	COG0088	Forms part of the polypeptide exit tunnel
AFE_RS01555	COG0089	rRNA binding
AFE_RS01560	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AFE_RS01565	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AFE_RS01570	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AFE_RS01580	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AFE_RS01585	COG0255	Belongs to the universal ribosomal protein uL29 family
AFE_RS01590	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AFE_RS01595	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AFE_RS01600	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AFE_RS01605	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AFE_RS01610	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AFE_RS01615	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AFE_RS01620	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AFE_RS01625	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AFE_RS01630	COG1841	ribosomal large subunit assembly
AFE_RS01635	COG0200	Binds to the 23S rRNA
AFE_RS01640	COG0201	protein transport
AFE_RS01645	COG0563	adenylate kinase activity
AFE_RS01650	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AFE_RS01655	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AFE_RS01660	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AFE_RS01665	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AFE_RS01670	COG0202	RNA polymerase activity
AFE_RS01675	COG0203	ribosomal protein L17
AFE_RS01680	COG0756	dUTP diphosphatase activity
AFE_RS01685	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AFE_RS01690	COG2003	Belongs to the UPF0758 family
AFE_RS01700	COG0671	phosphoesterase, PA-phosphatase related
AFE_RS01720	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AFE_RS01730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFE_RS01735	COG0678	peroxiredoxin activity
AFE_RS01735	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AFE_RS01740	COG0560	Phosphoserine phosphatase
AFE_RS01745	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AFE_RS01750	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AFE_RS01755	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AFE_RS01775	COG0492	ferredoxin-NADP+ reductase activity
AFE_RS01785	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AFE_RS01795	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AFE_RS01800	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AFE_RS01810	COG1376	ErfK ybiS ycfS ynhG family protein
AFE_RS01845	COG0779	Required for maturation of 30S ribosomal subunits
AFE_RS01850	COG0195	Participates in both transcription termination and antitermination
AFE_RS01855	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AFE_RS01860	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AFE_RS01865	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AFE_RS01870	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AFE_RS01875	COG1185	polyribonucleotide nucleotidyltransferase activity
AFE_RS01880	COG0612	Peptidase, M16
AFE_RS01885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFE_RS01895	COG0328	RNA-DNA hybrid ribonuclease activity
AFE_RS01900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AFE_RS01910	COG0346	lactoylglutathione lyase activity
AFE_RS01920	COG0137	argininosuccinate synthase activity
AFE_RS01925	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AFE_RS01930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AFE_RS01935	COG0527	aspartate kinase activity
AFE_RS01975	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AFE_RS01985	COG1388	LysM domain
AFE_RS01985	COG0741	lytic transglycosylase activity
AFE_RS01990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFE_RS02000	COG0538	isocitrate dehydrogenase activity
AFE_RS02005	COG0045	succinate-CoA ligase (ADP-forming) activity
AFE_RS02015	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AFE_RS02020	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AFE_RS02020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFE_RS02050	COG1850	ribulose-bisphosphate carboxylase activity
AFE_RS02055	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
AFE_RS02060	COG0235	Class ii aldolase
AFE_RS02070	COG0242	peptide deformylase activity
AFE_RS02075	COG0531	amino acid
AFE_RS02100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AFE_RS02110	COG2204	response regulator
AFE_RS02120	COG2205	protein histidine kinase activity
AFE_RS02125	COG0497	DNA recombination
AFE_RS02130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AFE_RS02135	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AFE_RS02140	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AFE_RS02140	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AFE_RS02145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AFE_RS02155	COG1466	dna polymerase III delta subunit
AFE_RS02165	COG0495	leucyl-tRNA aminoacylation
AFE_RS02170	COG0655	NAD(P)H dehydrogenase (quinone) activity
AFE_RS02175	COG2353	YceI-like domain
AFE_RS02180	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AFE_RS02185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AFE_RS02210	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AFE_RS02215	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AFE_RS02230	COG0436	Aminotransferase
AFE_RS02240	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AFE_RS02250	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AFE_RS02255	COG4456	Virulence-associated protein
AFE_RS02260	COG1487	ribonuclease activity
AFE_RS02265	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AFE_RS02270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AFE_RS02280	COG1136	(ABC) transporter
AFE_RS02290	COG0658	competence protein
AFE_RS02290	COG2333	competence protein COMEC
AFE_RS02295	COG0811	peptide transport
AFE_RS02300	COG0848	biopolymer transport protein
AFE_RS02315	COG1663	tetraacyldisaccharide 4'-kinase activity
AFE_RS02320	COG2835	tetraacyldisaccharide 4'-kinase activity
AFE_RS02325	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AFE_RS02350	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AFE_RS02375	COG2329	Antibiotic biosynthesis monooxygenase
AFE_RS02395	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AFE_RS02400	COG4974	Belongs to the 'phage' integrase family
AFE_RS02410	COG3267	Type II secretory pathway component ExeA
AFE_RS02410	COG3409	Peptidoglycan-binding domain 1 protein
AFE_RS02435	COG1573	uracil-dna glycosylase
AFE_RS02440	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AFE_RS02445	COG0542	response to heat
AFE_RS02450	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AFE_RS02455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AFE_RS02460	COG0693	protein deglycase activity
AFE_RS02465	COG0793	Belongs to the peptidase S41A family
AFE_RS02475	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AFE_RS02480	COG0058	SHG alpha-glucan phosphorylase activity
AFE_RS02490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFE_RS02495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFE_RS02505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AFE_RS02510	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AFE_RS02535	COG0529	Catalyzes the synthesis of activated sulfate
AFE_RS02535	COG2046	Belongs to the sulfate adenylyltransferase family
AFE_RS02545	COG0459	protein refolding
AFE_RS02550	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AFE_RS02575	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AFE_RS02590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFE_RS02610	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AFE_RS02615	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AFE_RS02620	COG0196	riboflavin kinase activity
AFE_RS02640	COG1561	YicC-like family, N-terminal region
AFE_RS02645	COG0194	GDP metabolic process
AFE_RS02650	COG1758	RNA polymerase activity
AFE_RS02655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFE_RS02685	COG0628	permease
AFE_RS02690	COG1355	regulation of microtubule-based process
AFE_RS02695	COG2078	PFAM AMMECR1 domain protein
AFE_RS02705	COG1538	Outer membrane efflux protein
AFE_RS02765	COG0513	Belongs to the DEAD box helicase family
AFE_RS02770	COG1278	Cold shock
AFE_RS02775	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AFE_RS02780	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AFE_RS02790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AFE_RS02800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFE_RS02805	COG1702	phosphate starvation-inducible protein PhoH
AFE_RS02810	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AFE_RS02820	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AFE_RS02825	COG0312	modulator of DNA gyrase
AFE_RS02835	COG1121	(ABC) transporter
AFE_RS02845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFE_RS02890	COG0438	transferase activity, transferring glycosyl groups
AFE_RS02895	COG0438	transferase activity, transferring glycosyl groups
AFE_RS02900	COG1132	(ABC) transporter
AFE_RS02905	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AFE_RS02930	COG2226	methyltransferase
AFE_RS02935	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AFE_RS02940	COG0066	3-isopropylmalate dehydratase activity
AFE_RS02950	COG0259	pyridoxamine-phosphate oxidase activity
AFE_RS02955	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AFE_RS02970	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AFE_RS02975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AFE_RS02990	COG0109	protoheme IX farnesyltransferase activity
AFE_RS02995	COG2814	Major facilitator Superfamily
AFE_RS03000	COG1968	undecaprenyl-diphosphatase activity
AFE_RS03005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AFE_RS03015	COG0505	Belongs to the CarA family
AFE_RS03030	COG2022	thiamine diphosphate biosynthetic process
AFE_RS03040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AFE_RS03045	COG0163	prenyltransferase activity
AFE_RS03050	COG1127	ABC transporter
AFE_RS03055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AFE_RS03075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AFE_RS03085	COG0577	efflux transmembrane transporter activity
AFE_RS03090	COG1136	(ABC) transporter
AFE_RS03110	COG0254	rRNA binding
AFE_RS03115	COG0281	malic enzyme
AFE_RS03120	COG0628	permease
AFE_RS03125	COG0129	dihydroxy-acid dehydratase activity
AFE_RS03135	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AFE_RS03135	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AFE_RS03140	COG0271	Belongs to the BolA IbaG family
AFE_RS03145	COG2350	Protein conserved in bacteria
AFE_RS03150	COG2917	probably involved in intracellular septation
AFE_RS03165	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AFE_RS03175	COG1959	2 iron, 2 sulfur cluster binding
AFE_RS03180	COG1104	cysteine desulfurase activity
AFE_RS03185	COG0822	iron-sulfur transferase activity
AFE_RS03195	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AFE_RS03200	COG0443	Heat shock 70 kDa protein
AFE_RS03215	COG0482	sulfurtransferase activity
AFE_RS03220	COG1752	Esterase of the alpha-beta hydrolase superfamily
AFE_RS03245	COG0732	type I restriction modification DNA specificity domain
AFE_RS03265	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AFE_RS03280	COG3284	Transcriptional regulator
AFE_RS03290	COG3791	Glutathione-dependent formaldehyde-activating
AFE_RS03295	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AFE_RS03300	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AFE_RS03305	COG0583	DNA-binding transcription factor activity
AFE_RS03310	COG2204	response regulator
AFE_RS03360	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AFE_RS03375	COG0298	carbon dioxide binding
AFE_RS03380	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AFE_RS03395	COG0375	protein maturation
AFE_RS03420	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AFE_RS03450	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AFE_RS03455	COG0493	'glutamate synthase
AFE_RS03460	COG0067	glutamate synthase
AFE_RS03460	COG0069	glutamate synthase activity
AFE_RS03460	COG0070	glutamate synthase
AFE_RS03465	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AFE_RS03470	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AFE_RS03475	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AFE_RS03480	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AFE_RS03515	COG0432	Pfam Uncharacterised protein family UPF0047
AFE_RS03525	COG1193	negative regulation of DNA recombination
AFE_RS03530	COG0028	Belongs to the TPP enzyme family
AFE_RS03540	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AFE_RS03545	COG0688	phosphatidylethanolamine metabolic process
AFE_RS03550	COG1183	phosphatidylcholine synthase activity
AFE_RS03560	COG0589	response to stress
AFE_RS03565	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AFE_RS03570	COG1196	nuclear chromosome segregation
AFE_RS03585	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AFE_RS03615	COG0730	response to heat
AFE_RS03620	COG0811	peptide transport
AFE_RS03625	COG0848	biopolymer transport protein
AFE_RS03640	COG0402	S-adenosylhomocysteine deaminase activity
AFE_RS03645	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AFE_RS03680	COG3608	succinylglutamate desuccinylase aspartoacylase
AFE_RS03680	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AFE_RS03740	COG0475	glutathione-regulated potassium exporter activity
AFE_RS03745	COG1028	Short-chain dehydrogenase reductase Sdr
AFE_RS03820	COG2080	2 iron, 2 sulfur cluster binding
AFE_RS03820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AFE_RS03835	COG2814	Major facilitator Superfamily
AFE_RS03840	COG0038	chloride channel
AFE_RS03850	COG0583	DNA-binding transcription factor activity
AFE_RS03905	COG4974	Belongs to the 'phage' integrase family
AFE_RS03910	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AFE_RS03925	COG3267	Type II secretory pathway component ExeA
AFE_RS03925	COG3409	Peptidoglycan-binding domain 1 protein
AFE_RS03935	COG1196	nuclear chromosome segregation
AFE_RS03940	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AFE_RS03960	COG1064	alcohol dehydrogenase
AFE_RS03965	COG0504	CTP synthase activity
AFE_RS03970	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AFE_RS03975	COG0148	phosphopyruvate hydratase activity
AFE_RS03980	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AFE_RS03985	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AFE_RS03995	COG0322	excinuclease ABC activity
AFE_RS04020	COG3189	MarR family transcriptional regulator
AFE_RS04035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFE_RS04035	COG1017	nitric oxide dioxygenase activity
AFE_RS04040	COG1566	PFAM secretion protein HlyD family protein
AFE_RS04045	COG1538	Outer membrane efflux protein
AFE_RS04050	COG2814	Major facilitator Superfamily
AFE_RS04055	COG0583	DNA-binding transcription factor activity
AFE_RS04080	COG2161	toxin-antitoxin pair type II binding
AFE_RS04095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AFE_RS04120	COG1247	-acetyltransferase
AFE_RS04165	COG0393	Putative heavy-metal-binding
AFE_RS04175	COG2026	Addiction module toxin, RelE StbE family
AFE_RS04185	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AFE_RS04190	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AFE_RS04200	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AFE_RS04205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFE_RS04215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFE_RS04220	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AFE_RS04225	COG0287	Prephenate dehydrogenase
AFE_RS04230	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AFE_RS04235	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AFE_RS04245	COG0776	regulation of translation
AFE_RS04250	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AFE_RS04255	COG0284	orotidine-5'-phosphate decarboxylase activity
AFE_RS04260	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AFE_RS04265	COG0544	peptidyl-prolyl cis-trans isomerase activity
AFE_RS04275	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AFE_RS04280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AFE_RS04300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AFE_RS04305	COG0671	phosphoesterase, PA-phosphatase related
AFE_RS04330	COG2915	High frequency lysogenization protein hflD homolog
AFE_RS04335	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AFE_RS04340	COG0024	Methionine aminopeptidase
AFE_RS04345	COG1489	DNA binding
AFE_RS04350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFE_RS04360	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AFE_RS04365	COG1058	Belongs to the CinA family
AFE_RS04365	COG1546	Belongs to the CinA family
AFE_RS04370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AFE_RS04375	COG2137	regulation of response to DNA damage stimulus
AFE_RS04415	COG0739	heme binding
AFE_RS04415	COG0741	lytic transglycosylase activity
AFE_RS04415	COG1196	nuclear chromosome segregation
AFE_RS04420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AFE_RS04435	COG0488	(ABC) transporter
AFE_RS04440	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AFE_RS04465	COG1294	oxidase, subunit
AFE_RS04490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFE_RS04505	COG3416	Protein conserved in bacteria
AFE_RS04505	COG2943	transferase activity, transferring hexosyl groups
AFE_RS04515	COG2363	Small membrane protein
AFE_RS04560	COG0616	signal peptide processing
AFE_RS04565	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AFE_RS04570	COG0314	molybdopterin synthase activity
AFE_RS04575	COG1666	GTP binding
AFE_RS04585	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AFE_RS04590	COG0509	glycine decarboxylation via glycine cleavage system
AFE_RS04595	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFE_RS04600	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFE_RS04605	COG1132	(ABC) transporter
AFE_RS04610	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AFE_RS04615	COG0450	alkyl hydroperoxide reductase
AFE_RS04625	COG0613	PHP domain protein
AFE_RS04630	COG0628	permease
AFE_RS04650	COG0084	hydrolase, TatD family'
AFE_RS04655	COG0321	lipoyl(octanoyl) transferase activity
AFE_RS04655	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AFE_RS04665	COG0582	viral genome integration into host DNA
AFE_RS04745	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AFE_RS04760	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AFE_RS04795	COG1994	Peptidase M50
AFE_RS04905	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AFE_RS04955	COG0675	Transposase, IS605 OrfB family
AFE_RS05010	COG0776	regulation of translation
AFE_RS05100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AFE_RS05120	COG0681	Belongs to the peptidase S26 family
AFE_RS05155	COG2336	PFAM SpoVT AbrB
AFE_RS05240	COG0501	Belongs to the peptidase M48B family
AFE_RS05360	COG0210	DNA helicase
AFE_RS05400	COG4974	Belongs to the 'phage' integrase family
AFE_RS05675	COG0328	RNA-DNA hybrid ribonuclease activity
AFE_RS05735	COG0457	Tetratricopeptide repeat
AFE_RS05755	COG0675	Transposase, IS605 OrfB family
AFE_RS05825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AFE_RS05885	COG0776	regulation of translation
AFE_RS05970	COG0629	single-stranded DNA binding
AFE_RS06125	COG2204	response regulator
AFE_RS06130	COG0583	DNA-binding transcription factor activity
AFE_RS06280	COG0671	phosphoesterase, PA-phosphatase related
AFE_RS06300	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AFE_RS06330	COG0438	transferase activity, transferring glycosyl groups
AFE_RS06340	COG0438	transferase activity, transferring glycosyl groups
AFE_RS06345	COG0367	asparagine synthase
AFE_RS06350	COG0297	glycogen (starch) synthase activity
AFE_RS06355	COG0438	transferase activity, transferring glycosyl groups
AFE_RS06365	COG0438	transferase activity, transferring glycosyl groups
AFE_RS06410	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AFE_RS06410	COG0662	Cupin 2, conserved barrel domain protein
AFE_RS06440	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AFE_RS06450	COG1484	DNA-dependent DNA replication
AFE_RS06455	COG4584	PFAM Integrase catalytic
AFE_RS06465	COG3415	Transposase
AFE_RS06470	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AFE_RS06510	COG4988	ABC transporter
AFE_RS06515	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AFE_RS06525	COG0354	folic acid binding
AFE_RS06535	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AFE_RS06550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFE_RS06555	COG0481	GTPase activity
AFE_RS06560	COG0681	Belongs to the peptidase S26 family
AFE_RS06570	COG0571	ribonuclease III activity
AFE_RS06575	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AFE_RS06580	COG1381	Involved in DNA repair and RecF pathway recombination
AFE_RS06585	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AFE_RS06590	COG0736	holo-[acyl-carrier-protein] synthase activity
AFE_RS06600	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AFE_RS06600	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AFE_RS06605	COG0037	tRNA processing
AFE_RS06610	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AFE_RS06665	COG0438	transferase activity, transferring glycosyl groups
AFE_RS06680	COG1230	cation diffusion facilitator family transporter
AFE_RS06690	COG0513	Belongs to the DEAD box helicase family
AFE_RS06705	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AFE_RS06710	COG0573	inorganic phosphate transmembrane transporter activity
AFE_RS06715	COG0581	inorganic phosphate transmembrane transporter activity
AFE_RS06720	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AFE_RS06725	COG0704	Plays a role in the regulation of phosphate uptake
AFE_RS06740	COG0052	Belongs to the universal ribosomal protein uS2 family
AFE_RS06745	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AFE_RS06750	COG0528	UMP kinase activity
AFE_RS06760	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AFE_RS06765	COG0575	Belongs to the CDS family
AFE_RS06770	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AFE_RS06790	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AFE_RS06795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AFE_RS06800	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AFE_RS06805	COG0673	inositol 2-dehydrogenase activity
AFE_RS06815	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AFE_RS06820	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AFE_RS06830	COG0825	malonyl-CoA metabolic process
AFE_RS06835	COG0037	tRNA processing
AFE_RS06845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AFE_RS06850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFE_RS06860	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AFE_RS06865	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AFE_RS06870	COG1166	arginine decarboxylase activity
AFE_RS06915	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AFE_RS06940	COG0811	peptide transport
AFE_RS06955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AFE_RS06960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFE_RS06965	COG1120	ATPase activity
AFE_RS06975	COG0725	ABC transporter, periplasmic molybdate-binding protein
AFE_RS06985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFE_RS07000	COG0725	ABC transporter, periplasmic molybdate-binding protein
AFE_RS07020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFE_RS07075	COG5420	small protein containing a coiled-coil domain
AFE_RS07090	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AFE_RS07095	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AFE_RS07110	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AFE_RS07120	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AFE_RS07150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AFE_RS07185	COG1104	cysteine desulfurase activity
AFE_RS07190	COG5554	nitrogen fixation
AFE_RS07200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AFE_RS07205	COG0633	Ferredoxin
AFE_RS07230	COG1012	belongs to the aldehyde dehydrogenase family
AFE_RS07250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFE_RS07255	COG0438	transferase activity, transferring glycosyl groups
AFE_RS07260	COG0438	transferase activity, transferring glycosyl groups
AFE_RS07265	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AFE_RS07280	COG4974	Belongs to the 'phage' integrase family
AFE_RS07325	COG1484	DNA-dependent DNA replication
AFE_RS07340	COG0629	single-stranded DNA binding
AFE_RS07370	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AFE_RS07390	COG0776	regulation of translation
AFE_RS07405	COG3077	Addiction module antitoxin, RelB DinJ family
AFE_RS07450	COG0842	Transport permease protein
AFE_RS07455	COG0842	Transport permease protein
AFE_RS07460	COG1131	(ABC) transporter
AFE_RS07465	COG1131	(ABC) transporter
AFE_RS07490	COG1569	PIN domain
AFE_RS07495	COG3311	Transcriptional regulator
AFE_RS07560	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AFE_RS07575	COG4962	Type ii secretion system protein e
AFE_RS07600	COG3451	type IV secretory pathway VirB4
AFE_RS07640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFE_RS07660	COG2084	Dehydrogenase
AFE_RS07665	COG0243	molybdopterin cofactor binding
AFE_RS07675	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AFE_RS07685	COG0633	Ferredoxin
AFE_RS07685	COG0543	2 iron, 2 sulfur cluster binding
AFE_RS07690	COG1151	hydroxylamine reductase activity
AFE_RS07705	COG3002	Belongs to the UPF0753 family
AFE_RS07710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AFE_RS07715	COG0247	lactate metabolic process
AFE_RS07720	COG0277	FAD linked oxidase domain protein
AFE_RS07725	COG0277	FAD linked oxidase domain protein
AFE_RS07760	COG0418	dihydroorotase activity
AFE_RS07765	COG0129	dihydroxy-acid dehydratase activity
AFE_RS07770	COG0009	L-threonylcarbamoyladenylate synthase
AFE_RS07780	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AFE_RS07785	COG0191	fructose-bisphosphate aldolase activity
AFE_RS07800	COG1192	Involved in chromosome partitioning
AFE_RS07815	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AFE_RS07820	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AFE_RS07825	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AFE_RS07855	COG1850	ribulose-bisphosphate carboxylase activity
AFE_RS07870	COG3701	Conjugal transfer protein
AFE_RS07995	COG1475	DNA binding
AFE_RS08000	COG1192	Involved in chromosome partitioning
AFE_RS08015	COG0667	Aldo Keto reductase
AFE_RS08060	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AFE_RS08065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AFE_RS08075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AFE_RS08080	COG3284	Transcriptional regulator
AFE_RS08085	COG1012	belongs to the aldehyde dehydrogenase family
AFE_RS08120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AFE_RS08130	COG3158	transport of potassium into the cell
AFE_RS08170	COG1666	GTP binding
AFE_RS08175	COG0438	transferase activity, transferring glycosyl groups
AFE_RS08180	COG0670	Belongs to the BI1 family
AFE_RS08205	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AFE_RS08210	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AFE_RS08215	COG1428	Deoxynucleoside kinase
AFE_RS08225	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AFE_RS08225	COG0617	tRNA 3'-terminal CCA addition
AFE_RS08225	COG3620	sequence-specific DNA binding
AFE_RS08235	COG0463	Glycosyl transferase, family 2
AFE_RS08245	COG0519	Catalyzes the synthesis of GMP from XMP
AFE_RS08245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AFE_RS08250	COG4691	Plasmid stability protein
AFE_RS08255	COG1487	ribonuclease activity
AFE_RS08265	COG0531	amino acid
AFE_RS08270	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AFE_RS08275	COG3264	Mechanosensitive ion channel
AFE_RS08275	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AFE_RS08290	COG0009	L-threonylcarbamoyladenylate synthase
AFE_RS08295	COG1994	Peptidase M50
AFE_RS08300	COG0180	Tryptophanyl-tRNA synthetase
AFE_RS08305	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AFE_RS08310	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AFE_RS08315	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFE_RS08320	COG1187	pseudouridine synthase activity
AFE_RS08340	COG2814	Major facilitator Superfamily
AFE_RS08355	COG0148	phosphopyruvate hydratase activity
AFE_RS08380	COG1105	Belongs to the carbohydrate kinase PfkB family
AFE_RS08385	COG0280	phosphate acetyltransferase
AFE_RS08390	COG0477	Major facilitator Superfamily
AFE_RS08395	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AFE_RS08400	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFE_RS08405	COG0022	dehydrogenase e1 component
AFE_RS08410	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AFE_RS08420	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AFE_RS08425	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFE_RS08425	COG0574	Belongs to the PEP-utilizing enzyme family
AFE_RS08440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFE_RS08445	COG2171	N-acyltransferase activity
AFE_RS08465	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AFE_RS08470	COG0402	S-adenosylhomocysteine deaminase activity
AFE_RS08480	COG1388	LysM domain
AFE_RS08480	COG0791	NLP P60 protein
AFE_RS08505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AFE_RS08540	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AFE_RS08560	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AFE_RS08565	COG1216	Glycosyl transferase, family 2
AFE_RS08590	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AFE_RS08595	COG1028	Short-chain dehydrogenase reductase Sdr
AFE_RS08605	COG2154	pterin-4-alpha-carbinolamine dehydratase
AFE_RS08635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AFE_RS08650	COG0587	DNA-directed DNA polymerase activity
AFE_RS08660	COG0308	aminopeptidase N
AFE_RS08680	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AFE_RS08685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFE_RS08705	COG0424	maF-like protein
AFE_RS08710	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AFE_RS08715	COG1923	regulation of RNA biosynthetic process
AFE_RS08720	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AFE_RS08725	COG0330	HflC and HflK could
AFE_RS08730	COG0330	HflC and HflK could
AFE_RS08735	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AFE_RS08760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFE_RS08765	COG1058	Belongs to the CinA family
AFE_RS08765	COG1546	Belongs to the CinA family
AFE_RS08775	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AFE_RS08780	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AFE_RS08790	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AFE_RS08795	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AFE_RS08800	COG1295	ribonuclease BN
AFE_RS08810	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AFE_RS08815	COG0416	fatty acid biosynthetic process
AFE_RS08820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFE_RS08825	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AFE_RS08835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AFE_RS08840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AFE_RS08855	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AFE_RS08880	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AFE_RS08885	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AFE_RS08890	COG0004	ammonium transporteR
AFE_RS08895	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AFE_RS08895	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AFE_RS08900	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AFE_RS08910	COG0802	atpase or kinase
AFE_RS08915	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AFE_RS08920	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AFE_RS08925	COG0105	UTP biosynthetic process
AFE_RS08930	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AFE_RS08945	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AFE_RS08950	COG0124	histidyl-tRNA synthetase
AFE_RS08965	COG1160	GTP binding
AFE_RS09000	COG0730	response to heat
AFE_RS09010	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFE_RS09030	COG1881	PFAM PEBP family protein
AFE_RS09040	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AFE_RS09065	COG0729	surface antigen
AFE_RS09085	COG4654	Cytochrome c, class I
AFE_RS09110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFE_RS09120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFE_RS09135	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AFE_RS09140	COG1469	GTP cyclohydrolase I activity
AFE_RS09145	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AFE_RS09150	COG0142	geranyltranstransferase activity
AFE_RS09160	COG2223	nitrite transmembrane transporter activity
AFE_RS09170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFE_RS09175	COG1570	exodeoxyribonuclease VII activity
AFE_RS09180	COG2010	Cytochrome c
AFE_RS09180	COG4993	Dehydrogenase
AFE_RS09190	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AFE_RS09195	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AFE_RS09200	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AFE_RS09205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFE_RS09225	COG0583	DNA-binding transcription factor activity
AFE_RS09230	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFE_RS09235	COG2197	response regulator
AFE_RS09245	COG3916	Acyl-homoserine-lactone synthase
AFE_RS09305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AFE_RS09310	COG0456	acetyltransferase
AFE_RS09340	COG2217	Heavy metal translocating P-type atpase
AFE_RS09345	COG0436	Aminotransferase
AFE_RS09355	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AFE_RS09360	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AFE_RS09365	COG0640	Transcriptional regulator
AFE_RS09370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AFE_RS09380	COG0187	DNA topoisomerase II activity
AFE_RS09385	COG0642	Histidine kinase
AFE_RS09470	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AFE_RS09485	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AFE_RS09490	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AFE_RS09495	COG1862	Preprotein translocase
AFE_RS09500	COG0343	queuine tRNA-ribosyltransferase activity
AFE_RS09505	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AFE_RS09510	COG1253	flavin adenine dinucleotide binding
AFE_RS09525	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AFE_RS09535	COG0285	dihydrofolate synthase activity
AFE_RS09540	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AFE_RS09545	COG0159	tryptophan synthase activity
AFE_RS09550	COG0133	tryptophan synthase activity
AFE_RS09555	COG0135	phosphoribosylanthranilate isomerase activity
AFE_RS09560	COG0101	tRNA pseudouridine synthase activity
AFE_RS09570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AFE_RS09580	COG0746	molybdenum cofactor guanylyltransferase activity
AFE_RS09585	COG1763	Mo-molybdopterin cofactor biosynthetic process
AFE_RS09590	COG0303	'Molybdopterin
AFE_RS09595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AFE_RS09600	COG0616	signal peptide processing
AFE_RS09615	COG0438	transferase activity, transferring glycosyl groups
AFE_RS09645	COG0501	Belongs to the peptidase M48B family
AFE_RS09650	COG0477	Major facilitator Superfamily
AFE_RS09690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFE_RS09695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFE_RS09720	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFE_RS09725	COG0154	amidase activity
AFE_RS09730	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFE_RS09765	COG3394	polysaccharide catabolic process
AFE_RS09780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFE_RS09785	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AFE_RS09790	COG1657	PFAM Prenyltransferase squalene oxidase
AFE_RS09795	COG1562	ergosterol biosynthetic process
AFE_RS09800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AFE_RS09805	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AFE_RS09830	COG0442	prolyl-tRNA aminoacylation
AFE_RS09850	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AFE_RS09865	COG1692	metallophosphoesterase
AFE_RS09870	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AFE_RS09885	COG0768	penicillin binding
AFE_RS09890	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AFE_RS09895	COG0193	aminoacyl-tRNA hydrolase activity
AFE_RS09900	COG0012	GTP binding
AFE_RS09905	COG1396	sequence-specific DNA binding
AFE_RS09910	COG0651	ATP synthesis coupled electron transport
AFE_RS09915	COG0650	Formate hydrogenlyase subunit 4
AFE_RS09925	COG0651	ATP synthesis coupled electron transport
AFE_RS09930	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
AFE_RS09930	COG3261	NADH dehydrogenase
AFE_RS09935	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFE_RS09940	COG1850	ribulose-bisphosphate carboxylase activity
AFE_RS09960	COG2824	Alkylphosphonate utilization operon protein PhnA
AFE_RS09965	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AFE_RS10005	COG1649	PFAM Uncharacterised BCR, COG1649
AFE_RS10005	COG0726	polysaccharide deacetylase
AFE_RS10015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AFE_RS10020	COG0494	nUDIX hydrolase
AFE_RS10030	COG1187	pseudouridine synthase activity
AFE_RS10035	COG2957	Belongs to the agmatine deiminase family
AFE_RS10040	COG0243	molybdopterin cofactor binding
AFE_RS10070	COG0589	response to stress
AFE_RS10075	COG2814	Major facilitator Superfamily
AFE_RS10090	COG0210	DNA helicase
AFE_RS10095	COG0268	Binds directly to 16S ribosomal RNA
AFE_RS10100	COG3842	ATPase activity
AFE_RS10115	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AFE_RS10120	COG0514	ATP-dependent DNA helicase (RecQ)
AFE_RS10125	COG1965	Belongs to the frataxin family
AFE_RS10145	COG0795	lipopolysaccharide-transporting ATPase activity
AFE_RS10150	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AFE_RS10165	COG0525	valine-tRNA ligase activity
AFE_RS10170	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AFE_RS10190	COG0412	Dienelactone hydrolase
AFE_RS10195	COG1902	pentaerythritol trinitrate reductase activity
AFE_RS10210	COG3152	Membrane
AFE_RS10240	COG1530	ribonuclease E activity
AFE_RS10245	COG0215	cysteine-tRNA ligase activity
AFE_RS10250	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFE_RS10265	COG1028	Short-chain dehydrogenase reductase Sdr
AFE_RS10285	COG0745	RESPONSE REGULATOR receiver
AFE_RS10290	COG2205	protein histidine kinase activity
AFE_RS10300	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AFE_RS10305	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AFE_RS10310	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AFE_RS10320	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AFE_RS10375	COG4953	penicillin-binding protein 1C
AFE_RS10405	COG0138	bifunctional purine biosynthesis protein purh
AFE_RS10410	COG0151	Belongs to the GarS family
AFE_RS10415	COG0009	L-threonylcarbamoyladenylate synthase
AFE_RS10420	COG0408	coproporphyrinogen oxidase activity
AFE_RS10425	COG0167	dihydroorotate dehydrogenase activity
AFE_RS10450	COG0811	peptide transport
AFE_RS10465	COG0811	peptide transport
AFE_RS10485	COG0477	Major facilitator Superfamily
AFE_RS10490	COG3624	Phosphonate C-P lyase system protein PhnG
AFE_RS10495	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
AFE_RS10500	COG3626	phosphonate metabolism
AFE_RS10505	COG3627	carbon phosphorus lyase activity
AFE_RS10510	COG4107	phosphonate C-P lyase system protein PhnK
AFE_RS10515	COG4778	phosphonate C-P lyase system protein PhnL
AFE_RS10520	COG3454	Phosphonate metabolism
AFE_RS10530	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AFE_RS10535	COG2188	Transcriptional regulator
AFE_RS10555	COG1131	(ABC) transporter
AFE_RS10565	COG3511	phospholipase C
AFE_RS10575	COG0811	peptide transport
AFE_RS10590	COG4774	siderophore transport
AFE_RS10630	COG2814	Major facilitator Superfamily
AFE_RS10640	COG2062	phosphohistidine phosphatase, SixA
AFE_RS10665	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AFE_RS10670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFE_RS10685	COG0033	Phosphoglucomutase
AFE_RS10705	COG3038	cytochrome b561
AFE_RS10715	COG2814	Major facilitator Superfamily
AFE_RS10735	COG1193	negative regulation of DNA recombination
AFE_RS10745	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AFE_RS10755	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AFE_RS10760	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AFE_RS10775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AFE_RS10795	COG1686	Belongs to the peptidase S11 family
AFE_RS10820	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AFE_RS10825	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AFE_RS10835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AFE_RS10845	COG1272	protein, Hemolysin III
AFE_RS10850	COG0860	N-Acetylmuramoyl-L-alanine amidase
AFE_RS10860	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AFE_RS10865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFE_RS10875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFE_RS10880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFE_RS10890	COG0640	Transcriptional regulator
AFE_RS10940	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AFE_RS10945	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AFE_RS10960	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AFE_RS10970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFE_RS10975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFE_RS11000	COG3344	reverse transcriptase
AFE_RS11005	COG3344	reverse transcriptase
AFE_RS11020	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AFE_RS11025	COG4974	Belongs to the 'phage' integrase family
AFE_RS11070	COG0454	-acetyltransferase
AFE_RS11075	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFE_RS11085	COG1484	DNA-dependent DNA replication
AFE_RS11115	COG1230	cation diffusion facilitator family transporter
AFE_RS11165	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFE_RS11210	COG3385	transposase activity
AFE_RS11235	COG2217	Heavy metal translocating P-type atpase
AFE_RS11245	COG4654	Cytochrome c, class I
AFE_RS11265	COG0531	amino acid
AFE_RS11285	COG0347	Belongs to the P(II) protein family
AFE_RS11295	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AFE_RS11300	COG0569	domain protein
AFE_RS11300	COG0189	ligase activity
AFE_RS11305	COG0456	acetyltransferase
AFE_RS11320	COG4372	Transposase
AFE_RS11340	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AFE_RS11345	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AFE_RS11350	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AFE_RS11360	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AFE_RS11380	COG0789	Transcriptional regulator
AFE_RS11490	COG0789	Transcriptional regulator
AFE_RS11520	COG1199	ATP-dependent helicase activity
AFE_RS11530	COG0791	NLP P60 protein
AFE_RS11545	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AFE_RS11560	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AFE_RS11565	COG0586	Pfam SNARE associated Golgi protein
AFE_RS11580	COG0583	DNA-binding transcription factor activity
AFE_RS11595	COG0123	including yeast histone deacetylase and acetoin utilization protein
AFE_RS11645	COG0644	oxidoreductase
AFE_RS11650	COG0095	Lipoate-protein ligase
AFE_RS11660	COG0509	glycine decarboxylation via glycine cleavage system
AFE_RS11670	COG0509	glycine decarboxylation via glycine cleavage system
AFE_RS11675	COG2048	Heterodisulfide reductase, subunit B
AFE_RS11705	COG2210	Belongs to the sulfur carrier protein TusA family
AFE_RS11710	COG0425	Belongs to the sulfur carrier protein TusA family
AFE_RS11715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFE_RS11720	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AFE_RS11730	COG0315	cyclic pyranopterin monophosphate synthase activity
AFE_RS11735	COG1077	Cell shape determining protein MreB Mrl
AFE_RS11740	COG1792	Involved in formation and maintenance of cell shape
AFE_RS11750	COG0768	penicillin binding
AFE_RS11755	COG0772	Belongs to the SEDS family
AFE_RS11760	COG1686	Belongs to the peptidase S11 family
AFE_RS11770	COG0321	lipoyl(octanoyl) transferase activity
AFE_RS11775	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AFE_RS11825	COG0751	glycine-tRNA ligase activity
AFE_RS11830	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AFE_RS11840	COG0189	ligase activity
AFE_RS11860	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AFE_RS11890	COG0625	glutathione transferase activity
AFE_RS11895	COG1733	regulation of RNA biosynthetic process
AFE_RS11900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFE_RS11935	COG1131	(ABC) transporter
AFE_RS11955	COG0776	regulation of translation
AFE_RS11960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFE_RS11960	COG0072	phenylalanine-tRNA ligase activity
AFE_RS11965	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AFE_RS11970	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AFE_RS11975	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AFE_RS11980	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AFE_RS11985	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AFE_RS12000	COG1007	ATP synthesis coupled electron transport
AFE_RS12015	COG0713	ATP synthesis coupled electron transport
AFE_RS12025	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFE_RS12030	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AFE_RS12035	COG1034	ATP synthesis coupled electron transport
AFE_RS12045	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AFE_RS12050	COG0649	NAD binding
AFE_RS12055	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFE_RS12060	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFE_RS12065	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFE_RS12075	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AFE_RS12080	COG0149	triose-phosphate isomerase activity
AFE_RS12085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFE_RS12090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AFE_RS12095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFE_RS12100	COG0312	modulator of DNA gyrase
AFE_RS12105	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AFE_RS12105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFE_RS12110	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFE_RS12125	COG0477	Major facilitator Superfamily
AFE_RS12165	COG2372	response to copper ion
AFE_RS12165	COG1276	copper resistance
AFE_RS12175	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AFE_RS12205	COG0717	Belongs to the dCTP deaminase family
AFE_RS12210	COG0489	protein tyrosine kinase activity
AFE_RS12220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AFE_RS12225	COG0484	heat shock protein binding
AFE_RS12230	COG0443	Heat shock 70 kDa protein
AFE_RS12235	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AFE_RS12240	COG1420	regulation of RNA biosynthetic process
AFE_RS12245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AFE_RS12250	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AFE_RS12255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFE_RS12255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFE_RS12260	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AFE_RS12265	COG0114	fumarate hydratase activity
AFE_RS12290	COG0297	glycogen (starch) synthase activity
AFE_RS12295	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AFE_RS12305	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AFE_RS12350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFE_RS12365	COG2204	response regulator
AFE_RS12405	COG4964	Belongs to the GSP D family
AFE_RS12460	COG0457	Tetratricopeptide repeat
AFE_RS12490	COG0826	peptidase U32
AFE_RS12495	COG0826	peptidase U32
AFE_RS12500	COG3154	lipid carrier protein
AFE_RS12520	COG1028	Short-chain dehydrogenase reductase Sdr
AFE_RS12525	COG0723	plastoquinol--plastocyanin reductase activity
AFE_RS12530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AFE_RS12535	COG2857	Cytochrome c1
AFE_RS12560	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AFE_RS12565	COG1534	Rna-binding protein
AFE_RS12570	COG2967	ApaG domain
AFE_RS12575	COG2226	methyltransferase
AFE_RS12595	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AFE_RS12605	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AFE_RS12615	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AFE_RS12630	COG2177	Part of the ABC transporter FtsEX involved in
AFE_RS12635	COG2884	Cell division ATP-binding protein ftsE
AFE_RS12640	COG0552	protein localization to endoplasmic reticulum
AFE_RS12645	COG0742	ribosomal rna small subunit methyltransferase
AFE_RS12650	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AFE_RS12655	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AFE_RS12660	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AFE_RS12665	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AFE_RS12670	COG2890	protein-(glutamine-N5) methyltransferase activity
AFE_RS12675	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AFE_RS12680	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AFE_RS12690	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AFE_RS12695	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AFE_RS12705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AFE_RS12740	COG0625	glutathione transferase activity
AFE_RS12800	COG0393	Putative heavy-metal-binding
AFE_RS12810	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AFE_RS12820	COG0732	type I restriction modification DNA specificity domain
AFE_RS12835	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AFE_RS12855	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AFE_RS12920	COG0006	proline dipeptidase activity
AFE_RS12935	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AFE_RS12940	COG0305	Participates in initiation and elongation during chromosome replication
AFE_RS12945	COG0359	binds to the 23S rRNA
AFE_RS12960	COG0360	Binds together with S18 to 16S ribosomal RNA
AFE_RS12965	COG1472	Belongs to the glycosyl hydrolase 3 family
AFE_RS12970	COG0531	amino acid
AFE_RS12980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AFE_RS13005	COG0363	glucosamine-6-phosphate deaminase activity
AFE_RS13020	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AFE_RS13030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AFE_RS13040	COG1449	Belongs to the glycosyl hydrolase 57 family
AFE_RS13045	COG1940	carbohydrate kinase activity
AFE_RS13050	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AFE_RS13055	COG2733	membrane
AFE_RS13065	COG0629	single-stranded DNA binding
AFE_RS13080	COG3118	belongs to the thioredoxin family
AFE_RS13085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFE_RS13100	COG0335	large ribosomal subunit rRNA binding
AFE_RS13105	COG0336	Belongs to the RNA methyltransferase TrmD family
AFE_RS13110	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AFE_RS13115	COG0228	four-way junction DNA binding
AFE_RS13120	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AFE_RS13125	COG0431	NADPH-dependent FMN reductase
AFE_RS13140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AFE_RS13150	COG1131	(ABC) transporter
AFE_RS13155	COG0842	Transport permease protein
AFE_RS13160	COG0842	Transport permease protein
AFE_RS13185	COG0509	glycine decarboxylation via glycine cleavage system
AFE_RS13205	COG2210	Belongs to the sulfur carrier protein TusA family
AFE_RS13215	COG0631	protein serine/threonine phosphatase activity
AFE_RS13220	COG4245	von Willebrand factor, type A
AFE_RS13230	COG1573	uracil-dna glycosylase
AFE_RS13240	COG2336	PFAM SpoVT AbrB
AFE_RS13255	COG2336	PFAM SpoVT AbrB
AFE_RS13270	COG0488	(ABC) transporter
AFE_RS13300	COG0142	geranyltranstransferase activity
AFE_RS13315	COG3852	Histidine kinase
AFE_RS13325	COG2308	Evidence 4 Homologs of previously reported genes of
AFE_RS13340	COG2766	serine protein kinase
AFE_RS13345	COG0004	ammonium transporteR
AFE_RS13350	COG2718	Belongs to the UPF0229 family
AFE_RS13355	COG2719	SpoVR family
AFE_RS13365	COG0347	Belongs to the P(II) protein family
AFE_RS13370	COG0004	ammonium transporteR
AFE_RS13375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AFE_RS13375	COG0519	Catalyzes the synthesis of GMP from XMP
AFE_RS13390	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AFE_RS13400	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AFE_RS13405	COG1686	Belongs to the peptidase S11 family
AFE_RS13410	COG0166	Belongs to the GPI family
AFE_RS13420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AFE_RS13435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AFE_RS13445	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AFE_RS13450	COG1074	ATP-dependent DNA helicase activity
AFE_RS13455	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AFE_RS13515	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AFE_RS13525	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AFE_RS13535	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AFE_RS13550	COG0424	maF-like protein
AFE_RS13555	COG1530	ribonuclease E activity
AFE_RS13560	COG2204	response regulator
AFE_RS13570	COG2205	protein histidine kinase activity
AFE_RS13580	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AFE_RS13625	COG0175	sulfate reduction
AFE_RS13630	COG0529	Catalyzes the synthesis of activated sulfate
AFE_RS13630	COG2895	sulfate adenylyltransferase (ATP) activity
AFE_RS13695	COG1132	(ABC) transporter
AFE_RS13715	COG0444	Belongs to the ABC transporter superfamily
AFE_RS13720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFE_RS13725	COG0601	transmembrane transport
AFE_RS13750	COG2095	MarC family integral membrane protein
AFE_RS13755	COG0039	L-malate dehydrogenase activity
AFE_RS13765	COG0811	peptide transport
AFE_RS13770	COG0848	biopolymer transport protein
AFE_RS13785	COG3321	synthase
AFE_RS13785	COG0604	alcohol dehydrogenase
AFE_RS13785	COG1028	Short-chain dehydrogenase reductase Sdr
AFE_RS13790	COG0156	8-amino-7-oxononanoate synthase activity
AFE_RS13815	COG1194	a g-specific adenine glycosylase
AFE_RS13825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFE_RS13830	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFE_RS13840	COG1660	Displays ATPase and GTPase activities
AFE_RS13845	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AFE_RS13850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFE_RS13850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AFE_RS13850	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AFE_RS13870	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AFE_RS13880	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AFE_RS13905	COG3178	'Phosphotransferase
AFE_RS13910	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AFE_RS13915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AFE_RS13920	COG0842	Transport permease protein
AFE_RS13925	COG0271	Belongs to the BolA IbaG family
AFE_RS13930	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AFE_RS13935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AFE_RS13940	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AFE_RS13950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFE_RS13955	COG0131	Imidazoleglycerol-phosphate dehydratase
AFE_RS13960	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AFE_RS13965	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AFE_RS13970	COG0107	imidazoleglycerol-phosphate synthase activity
AFE_RS13975	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AFE_RS13975	COG0140	phosphoribosyl-ATP diphosphatase activity
AFE_RS13980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFE_RS13985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFE_RS13990	COG0805	protein transport
AFE_RS13995	COG1850	ribulose-bisphosphate carboxylase activity
AFE_RS14025	COG0540	Belongs to the ATCase OTCase family
AFE_RS14030	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AFE_RS14035	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AFE_RS14040	COG1678	Uncharacterized ACR, COG1678
AFE_RS14045	COG0189	ligase activity
AFE_RS14060	COG0316	Belongs to the HesB IscA family
AFE_RS14065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFE_RS14070	COG0022	dehydrogenase e1 component
AFE_RS14070	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFE_RS14075	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AFE_RS14090	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AFE_RS14095	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AFE_RS14100	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AFE_RS14120	COG0778	Nitroreductase
AFE_RS14155	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AFE_RS14160	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AFE_RS14170	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AFE_RS14175	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AFE_RS14180	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AFE_RS14180	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AFE_RS14185	COG1611	Belongs to the LOG family
AFE_RS14195	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AFE_RS14210	COG1555	photosystem II stabilization
AFE_RS14215	COG0210	DNA helicase
AFE_RS14235	COG1796	DNA polymerase
AFE_RS14235	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AFE_RS14245	COG1028	Short-chain dehydrogenase reductase Sdr
AFE_RS14250	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AFE_RS14260	COG1333	cytochrome c biogenesis protein
AFE_RS14265	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AFE_RS14310	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AFE_RS14315	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFE_RS14320	COG0175	sulfate reduction
AFE_RS14330	COG2895	sulfate adenylyltransferase (ATP) activity
AFE_RS14355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFE_RS14380	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AFE_RS14400	COG2814	Major facilitator Superfamily
AFE_RS14405	COG0109	protoheme IX farnesyltransferase activity
AFE_RS14415	COG4454	pyrroloquinoline quinone binding
AFE_RS14425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AFE_RS14430	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AFE_RS14460	COG0326	Molecular chaperone. Has ATPase activity
AFE_RS14470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AFE_RS14485	COG1131	(ABC) transporter
AFE_RS14550	COG1484	DNA-dependent DNA replication
AFE_RS14555	COG4584	PFAM Integrase catalytic
AFE_RS14565	COG3039	Transposase
AFE_RS14600	COG1715	Restriction endonuclease
AFE_RS14630	COG1196	nuclear chromosome segregation
AFE_RS14670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AFE_RS14685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AFE_RS14690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AFE_RS14695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AFE_RS14700	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AFE_RS14710	COG0356	it plays a direct role in the translocation of protons across the membrane
AFE_RS14720	COG1475	DNA binding
AFE_RS14730	COG0357	Ribosomal RNA small subunit methyltransferase G
AFE_RS14735	COG0445	tRNA wobble uridine modification
AFE_RS14750	COG0521	Mo-molybdopterin cofactor biosynthetic process
AFE_RS14780	COG0655	NAD(P)H dehydrogenase (quinone) activity
AFE_RS14825	COG1131	(ABC) transporter
AFE_RS14830	COG2945	thiolester hydrolase activity
AFE_RS14840	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AFE_RS14845	COG1959	2 iron, 2 sulfur cluster binding
AFE_RS14855	COG0134	indole-3-glycerol-phosphate synthase activity
AFE_RS14860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AFE_RS14875	COG0546	phosphoglycolate phosphatase activity
AFE_RS14880	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AFE_RS14895	COG0126	phosphoglycerate kinase activity
AFE_RS14900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AFE_RS14905	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AFE_RS14910	COG1494	fructose-1,6-bisphosphatase
AFE_RS14915	COG0483	inositol monophosphate 1-phosphatase activity
AFE_RS14925	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AFE_RS14930	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AFE_RS14935	COG1322	Protein conserved in bacteria
AFE_RS14940	COG1970	mechanosensitive ion channel activity
AFE_RS14950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFE_RS14960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFE_RS14970	COG1671	Belongs to the UPF0178 family
AFE_RS15015	COG0165	Argininosuccinate lyase
AFE_RS15030	COG1881	PFAM PEBP family protein
AFE_RS15055	COG2181	nitrate reductase activity
AFE_RS15055	COG0247	lactate metabolic process
AFE_RS15065	COG0375	protein maturation
AFE_RS15080	COG0409	Hydrogenase expression formation protein
AFE_RS15095	COG0662	Cupin 2, conserved barrel domain protein
AFE_RS15095	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AFE_RS15120	COG0113	porphobilinogen synthase activity
AFE_RS15130	COG0181	hydroxymethylbilane synthase activity
AFE_RS15140	COG0537	adenosine 5'-monophosphoramidase activity
AFE_RS15145	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AFE_RS15150	COG0352	thiamine-phosphate diphosphorylase activity
AFE_RS15155	COG0351	phosphomethylpyrimidine kinase
AFE_RS15165	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AFE_RS15215	COG0384	phenazine biosynthesis protein PhzF
AFE_RS15225	COG2932	Transcriptional regulator
AFE_RS15235	COG0741	lytic transglycosylase activity
AFE_RS15235	COG1196	nuclear chromosome segregation
AFE_RS15235	COG0739	heme binding
AFE_RS15255	COG0457	Tetratricopeptide repeat
AFE_RS15260	COG3617	BRO family, N-terminal domain
AFE_RS15345	COG3561	AntA/AntB antirepressor
AFE_RS15355	COG1215	transferase activity, transferring glycosyl groups
AFE_RS15370	COG3300	MHYT domain
AFE_RS15370	COG5001	Diguanylate cyclase
AFE_RS15400	COG0438	transferase activity, transferring glycosyl groups