locus-tag	class	description
ANFP_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ANFP_RS00010	COG0592	DNA-directed DNA polymerase activity
ANFP_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ANFP_RS00020	COG0187	DNA topoisomerase II activity
ANFP_RS00025	COG0493	'glutamate synthase
ANFP_RS00025	COG0543	2 iron, 2 sulfur cluster binding
ANFP_RS00060	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ANFP_RS00070	COG0850	regulation of cytokinetic process
ANFP_RS00075	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ANFP_RS00085	COG2922	Belongs to the Smg family
ANFP_RS00090	COG0758	DNA mediated transformation
ANFP_RS00100	COG0242	peptide deformylase activity
ANFP_RS00105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ANFP_RS00110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ANFP_RS00120	COG5000	phosphorelay sensor kinase activity
ANFP_RS00125	COG2204	response regulator
ANFP_RS00135	COG3852	Histidine kinase
ANFP_RS00140	COG2204	response regulator
ANFP_RS00145	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ANFP_RS00155	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ANFP_RS00160	COG0706	membrane insertase activity
ANFP_RS00165	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ANFP_RS00175	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ANFP_RS00180	COG0488	(ABC) transporter
ANFP_RS00190	COG1566	PFAM secretion protein HlyD family protein
ANFP_RS00270	COG2095	MarC family integral membrane protein
ANFP_RS00280	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ANFP_RS00285	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ANFP_RS00295	COG0217	transcriptional regulatory protein
ANFP_RS00300	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ANFP_RS00305	COG0632	four-way junction helicase activity
ANFP_RS00310	COG2255	four-way junction helicase activity
ANFP_RS00315	COG0824	Thioesterase
ANFP_RS00335	COG0823	Involved in the tonB-independent uptake of proteins
ANFP_RS00340	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ANFP_RS00345	COG0602	queuosine metabolic process
ANFP_RS00355	COG2885	chlorophyll binding
ANFP_RS00385	COG2226	methyltransferase
ANFP_RS00415	COG0438	transferase activity, transferring glycosyl groups
ANFP_RS00455	COG3177	Filamentation induced by cAMP protein fic
ANFP_RS00485	COG1252	NADH dehydrogenase
ANFP_RS00500	COG1136	(ABC) transporter
ANFP_RS00515	COG1914	H( )-stimulated, divalent metal cation uptake system
ANFP_RS00535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ANFP_RS00540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ANFP_RS00585	COG2833	Protein of unknown function (DUF455)
ANFP_RS00590	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ANFP_RS00600	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ANFP_RS00605	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ANFP_RS00610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ANFP_RS00615	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ANFP_RS00645	COG1484	DNA-dependent DNA replication
ANFP_RS00660	COG0629	single-stranded DNA binding
ANFP_RS00735	COG3311	Transcriptional regulator
ANFP_RS00790	COG4962	Type ii secretion system protein e
ANFP_RS00805	COG3451	type IV secretory pathway VirB4
ANFP_RS00835	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ANFP_RS00840	COG3657	addiction module killer protein
ANFP_RS00855	COG3701	Conjugal transfer protein
ANFP_RS00920	COG1475	DNA binding
ANFP_RS00925	COG1192	Involved in chromosome partitioning
ANFP_RS00960	COG3657	addiction module killer protein
ANFP_RS00965	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ANFP_RS00980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ANFP_RS01030	COG0583	DNA-binding transcription factor activity
ANFP_RS01050	COG0277	FAD linked oxidase domain protein
ANFP_RS01055	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ANFP_RS01060	COG0792	nuclease activity
ANFP_RS01065	COG3107	peptidoglycan biosynthetic process
ANFP_RS01090	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ANFP_RS01100	COG2363	Small membrane protein
ANFP_RS01110	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ANFP_RS01120	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ANFP_RS01125	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ANFP_RS01130	COG1127	ABC transporter
ANFP_RS01135	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ANFP_RS01140	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ANFP_RS01155	COG1131	(ABC) transporter
ANFP_RS01160	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ANFP_RS01165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ANFP_RS01175	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ANFP_RS01190	COG0018	arginyl-trna synthetase
ANFP_RS01200	COG0583	DNA-binding transcription factor activity
ANFP_RS01210	COG0708	Exodeoxyribonuclease III
ANFP_RS01220	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ANFP_RS01225	COG0625	glutathione transferase activity
ANFP_RS01230	COG0708	Exodeoxyribonuclease III
ANFP_RS01235	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ANFP_RS01240	COG1047	Peptidyl-prolyl cis-trans
ANFP_RS01245	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ANFP_RS01250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ANFP_RS01255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ANFP_RS01270	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ANFP_RS01275	COG0237	dephospho-CoA kinase activity
ANFP_RS01280	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
ANFP_RS01285	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ANFP_RS01295	COG0741	lytic transglycosylase activity
ANFP_RS01295	COG1196	nuclear chromosome segregation
ANFP_RS01295	COG0739	heme binding
ANFP_RS01300	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ANFP_RS01310	COG2264	protein methyltransferase activity
ANFP_RS01315	COG0439	Biotin carboxylase
ANFP_RS01325	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ANFP_RS01340	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ANFP_RS01350	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ANFP_RS01355	COG1181	Belongs to the D-alanine--D-alanine ligase family
ANFP_RS01360	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ANFP_RS01365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ANFP_RS01370	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ANFP_RS01375	COG0772	Belongs to the SEDS family
ANFP_RS01380	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ANFP_RS01385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ANFP_RS01390	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ANFP_RS01395	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ANFP_RS01410	COG0275	rRNA processing
ANFP_RS01415	COG2001	Belongs to the MraZ family
ANFP_RS01430	COG0617	tRNA 3'-terminal CCA addition
ANFP_RS01435	COG1022	Amp-dependent synthetase and ligase
ANFP_RS01440	COG0625	glutathione transferase activity
ANFP_RS01445	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ANFP_RS01455	COG0653	protein targeting
ANFP_RS01460	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ANFP_RS01465	COG0494	nUDIX hydrolase
ANFP_RS01470	COG0463	Glycosyl transferase, family 2
ANFP_RS01485	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ANFP_RS01515	COG1519	Transferase
ANFP_RS01520	COG1560	Kdo2-lipid A biosynthetic process
ANFP_RS01525	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ANFP_RS01530	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ANFP_RS01535	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ANFP_RS01540	COG1040	competence protein
ANFP_RS01545	COG0156	8-amino-7-oxononanoate synthase activity
ANFP_RS01550	COG2267	carboxylic ester hydrolase activity
ANFP_RS01555	COG2226	methyltransferase
ANFP_RS01560	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ANFP_RS01565	COG0501	Belongs to the peptidase M48B family
ANFP_RS01570	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ANFP_RS01575	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ANFP_RS01580	COG0390	transport system, permease component
ANFP_RS01590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ANFP_RS01590	COG0543	2 iron, 2 sulfur cluster binding
ANFP_RS01610	COG1309	transcriptional regulator
ANFP_RS01615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ANFP_RS01620	COG1566	PFAM secretion protein HlyD family protein
ANFP_RS01630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ANFP_RS01635	COG1872	DUF167
ANFP_RS01685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ANFP_RS01690	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ANFP_RS01695	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ANFP_RS01700	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ANFP_RS01715	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ANFP_RS01720	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ANFP_RS01740	COG0735	belongs to the Fur family
ANFP_RS01745	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ANFP_RS01750	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ANFP_RS01755	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ANFP_RS01760	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ANFP_RS01765	COG0659	secondary active sulfate transmembrane transporter activity
ANFP_RS01770	COG0288	reversible hydration of carbon dioxide
ANFP_RS01775	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ANFP_RS01780	COG2226	methyltransferase
ANFP_RS01790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ANFP_RS01790	COG2813	Specifically methylates the guanine in position
ANFP_RS01795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ANFP_RS01805	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ANFP_RS01810	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ANFP_RS01815	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ANFP_RS01815	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ANFP_RS01830	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ANFP_RS01835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ANFP_RS01855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ANFP_RS01880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ANFP_RS01900	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ANFP_RS01905	COG0081	regulation of translation
ANFP_RS01910	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ANFP_RS01915	COG0222	ribosome binding
ANFP_RS01920	COG0085	RNA polymerase activity
ANFP_RS01925	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ANFP_RS01930	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ANFP_RS01935	COG0049	tRNA binding
ANFP_RS01940	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ANFP_RS01945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ANFP_RS01950	COG0051	transcription antitermination factor activity, RNA binding
ANFP_RS01955	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ANFP_RS01960	COG0088	Forms part of the polypeptide exit tunnel
ANFP_RS01965	COG0089	rRNA binding
ANFP_RS01970	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ANFP_RS01975	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ANFP_RS01980	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ANFP_RS01990	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ANFP_RS01995	COG0255	Belongs to the universal ribosomal protein uL29 family
ANFP_RS02000	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ANFP_RS02005	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ANFP_RS02010	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ANFP_RS02015	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ANFP_RS02020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ANFP_RS02025	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ANFP_RS02030	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ANFP_RS02035	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ANFP_RS02040	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ANFP_RS02045	COG1841	ribosomal large subunit assembly
ANFP_RS02050	COG0200	Binds to the 23S rRNA
ANFP_RS02055	COG0201	protein transport
ANFP_RS02060	COG0563	adenylate kinase activity
ANFP_RS02065	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ANFP_RS02070	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ANFP_RS02075	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ANFP_RS02080	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ANFP_RS02085	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ANFP_RS02090	COG0202	RNA polymerase activity
ANFP_RS02095	COG0203	ribosomal protein L17
ANFP_RS02100	COG0756	dUTP diphosphatase activity
ANFP_RS02105	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ANFP_RS02110	COG2003	Belongs to the UPF0758 family
ANFP_RS02120	COG0671	phosphoesterase, PA-phosphatase related
ANFP_RS02140	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ANFP_RS02150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ANFP_RS02155	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ANFP_RS02155	COG0678	peroxiredoxin activity
ANFP_RS02165	COG0560	Phosphoserine phosphatase
ANFP_RS02170	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ANFP_RS02175	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ANFP_RS02180	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ANFP_RS02200	COG0492	ferredoxin-NADP+ reductase activity
ANFP_RS02210	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ANFP_RS02220	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ANFP_RS02225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ANFP_RS02235	COG1376	ErfK ybiS ycfS ynhG family protein
ANFP_RS02270	COG0779	Required for maturation of 30S ribosomal subunits
ANFP_RS02275	COG0195	Participates in both transcription termination and antitermination
ANFP_RS02280	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ANFP_RS02285	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ANFP_RS02290	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ANFP_RS02295	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ANFP_RS02300	COG1185	polyribonucleotide nucleotidyltransferase activity
ANFP_RS02305	COG0612	Peptidase, M16
ANFP_RS02310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ANFP_RS02320	COG0328	RNA-DNA hybrid ribonuclease activity
ANFP_RS02325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ANFP_RS02335	COG0346	lactoylglutathione lyase activity
ANFP_RS02345	COG0137	argininosuccinate synthase activity
ANFP_RS02350	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ANFP_RS02355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ANFP_RS02360	COG0527	aspartate kinase activity
ANFP_RS02380	COG4115	mRNA cleavage
ANFP_RS02410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ANFP_RS02420	COG0741	lytic transglycosylase activity
ANFP_RS02420	COG1388	LysM domain
ANFP_RS02425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ANFP_RS02435	COG0538	isocitrate dehydrogenase activity
ANFP_RS02440	COG0045	succinate-CoA ligase (ADP-forming) activity
ANFP_RS02450	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ANFP_RS02455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ANFP_RS02455	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ANFP_RS02485	COG1850	ribulose-bisphosphate carboxylase activity
ANFP_RS02490	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ANFP_RS02495	COG0235	Class ii aldolase
ANFP_RS02505	COG0242	peptide deformylase activity
ANFP_RS02510	COG0531	amino acid
ANFP_RS02535	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ANFP_RS02545	COG2204	response regulator
ANFP_RS02555	COG2205	protein histidine kinase activity
ANFP_RS02560	COG0497	DNA recombination
ANFP_RS02565	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ANFP_RS02570	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ANFP_RS02575	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ANFP_RS02575	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ANFP_RS02580	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ANFP_RS02590	COG1466	dna polymerase III delta subunit
ANFP_RS02600	COG0495	leucyl-tRNA aminoacylation
ANFP_RS02605	COG0655	NAD(P)H dehydrogenase (quinone) activity
ANFP_RS02610	COG2353	YceI-like domain
ANFP_RS02615	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ANFP_RS02620	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ANFP_RS02645	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ANFP_RS02650	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ANFP_RS02665	COG0436	Aminotransferase
ANFP_RS02675	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ANFP_RS02685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ANFP_RS02690	COG4456	Virulence-associated protein
ANFP_RS02695	COG1487	ribonuclease activity
ANFP_RS02705	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ANFP_RS02715	COG1136	(ABC) transporter
ANFP_RS02725	COG0658	competence protein
ANFP_RS02725	COG2333	competence protein COMEC
ANFP_RS02730	COG0811	peptide transport
ANFP_RS02735	COG0848	biopolymer transport protein
ANFP_RS02750	COG1663	tetraacyldisaccharide 4'-kinase activity
ANFP_RS02755	COG2835	tetraacyldisaccharide 4'-kinase activity
ANFP_RS02760	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ANFP_RS02785	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ANFP_RS02815	COG2329	Antibiotic biosynthesis monooxygenase
ANFP_RS02835	COG3409	Peptidoglycan-binding domain 1 protein
ANFP_RS02835	COG3267	Type II secretory pathway component ExeA
ANFP_RS02870	COG1573	uracil-dna glycosylase
ANFP_RS02875	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ANFP_RS02880	COG0542	response to heat
ANFP_RS02885	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ANFP_RS02890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ANFP_RS02895	COG0693	protein deglycase activity
ANFP_RS02900	COG0793	Belongs to the peptidase S41A family
ANFP_RS02910	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ANFP_RS02915	COG0058	SHG alpha-glucan phosphorylase activity
ANFP_RS02925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ANFP_RS02930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ANFP_RS02940	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ANFP_RS02945	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ANFP_RS02970	COG0529	Catalyzes the synthesis of activated sulfate
ANFP_RS02970	COG2046	Belongs to the sulfate adenylyltransferase family
ANFP_RS02980	COG0459	protein refolding
ANFP_RS02985	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ANFP_RS03010	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ANFP_RS03020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ANFP_RS03040	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ANFP_RS03045	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ANFP_RS03050	COG0196	riboflavin kinase activity
ANFP_RS03080	COG1561	YicC-like family, N-terminal region
ANFP_RS03085	COG0194	GDP metabolic process
ANFP_RS03090	COG1758	RNA polymerase activity
ANFP_RS03095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ANFP_RS03125	COG0628	permease
ANFP_RS03130	COG1355	regulation of microtubule-based process
ANFP_RS03135	COG2078	PFAM AMMECR1 domain protein
ANFP_RS03145	COG1538	Outer membrane efflux protein
ANFP_RS03180	COG0776	regulation of translation
ANFP_RS03185	COG0393	Putative heavy-metal-binding
ANFP_RS03195	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ANFP_RS03205	COG0732	type I restriction modification DNA specificity domain
ANFP_RS03215	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ANFP_RS03245	COG0776	regulation of translation
ANFP_RS03395	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ANFP_RS03395	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ANFP_RS03425	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
ANFP_RS03465	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ANFP_RS03505	COG4962	Type ii secretion system protein e
ANFP_RS03525	COG3451	type IV secretory pathway VirB4
ANFP_RS03565	COG2948	multi-organism process
ANFP_RS03610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ANFP_RS03625	COG1192	Involved in chromosome partitioning
ANFP_RS03630	COG1475	DNA binding
ANFP_RS03735	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ANFP_RS03745	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ANFP_RS03765	COG0393	Putative heavy-metal-binding
ANFP_RS03770	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
ANFP_RS03825	COG0513	Belongs to the DEAD box helicase family
ANFP_RS03830	COG1278	Cold shock
ANFP_RS03835	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ANFP_RS03840	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ANFP_RS03850	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ANFP_RS03860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ANFP_RS03865	COG1702	phosphate starvation-inducible protein PhoH
ANFP_RS03870	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ANFP_RS03880	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ANFP_RS03885	COG0312	modulator of DNA gyrase
ANFP_RS03895	COG1121	(ABC) transporter
ANFP_RS03905	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ANFP_RS03950	COG0438	transferase activity, transferring glycosyl groups
ANFP_RS03955	COG0438	transferase activity, transferring glycosyl groups
ANFP_RS03960	COG1132	(ABC) transporter
ANFP_RS03965	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ANFP_RS03990	COG2226	methyltransferase
ANFP_RS03995	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ANFP_RS04000	COG0066	3-isopropylmalate dehydratase activity
ANFP_RS04010	COG0259	pyridoxamine-phosphate oxidase activity
ANFP_RS04015	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ANFP_RS04025	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ANFP_RS04030	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ANFP_RS04045	COG0109	protoheme IX farnesyltransferase activity
ANFP_RS04050	COG2814	Major facilitator Superfamily
ANFP_RS04055	COG1968	undecaprenyl-diphosphatase activity
ANFP_RS04060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ANFP_RS04070	COG0505	Belongs to the CarA family
ANFP_RS04085	COG2022	thiamine diphosphate biosynthetic process
ANFP_RS04095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ANFP_RS04100	COG0163	prenyltransferase activity
ANFP_RS04105	COG1127	ABC transporter
ANFP_RS04110	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ANFP_RS04130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ANFP_RS04140	COG0577	efflux transmembrane transporter activity
ANFP_RS04145	COG1136	(ABC) transporter
ANFP_RS04165	COG0254	rRNA binding
ANFP_RS04170	COG0281	malic enzyme
ANFP_RS04175	COG0628	permease
ANFP_RS04180	COG0129	dihydroxy-acid dehydratase activity
ANFP_RS04190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ANFP_RS04190	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ANFP_RS04195	COG0271	Belongs to the BolA IbaG family
ANFP_RS04200	COG2350	Protein conserved in bacteria
ANFP_RS04205	COG2917	probably involved in intracellular septation
ANFP_RS04220	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ANFP_RS04230	COG1959	2 iron, 2 sulfur cluster binding
ANFP_RS04235	COG1104	cysteine desulfurase activity
ANFP_RS04240	COG0822	iron-sulfur transferase activity
ANFP_RS04250	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ANFP_RS04255	COG0443	Heat shock 70 kDa protein
ANFP_RS04270	COG0482	sulfurtransferase activity
ANFP_RS04275	COG1752	Esterase of the alpha-beta hydrolase superfamily
ANFP_RS04300	COG0732	type I restriction modification DNA specificity domain
ANFP_RS04320	COG4372	Transposase
ANFP_RS04330	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ANFP_RS04345	COG3284	Transcriptional regulator
ANFP_RS04350	COG3791	Glutathione-dependent formaldehyde-activating
ANFP_RS04355	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ANFP_RS04360	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ANFP_RS04365	COG0583	DNA-binding transcription factor activity
ANFP_RS04370	COG2204	response regulator
ANFP_RS04420	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ANFP_RS04435	COG0298	carbon dioxide binding
ANFP_RS04440	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ANFP_RS04455	COG0375	protein maturation
ANFP_RS04480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ANFP_RS04510	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ANFP_RS04515	COG0493	'glutamate synthase
ANFP_RS04520	COG0070	glutamate synthase
ANFP_RS04520	COG0067	glutamate synthase
ANFP_RS04520	COG0069	glutamate synthase activity
ANFP_RS04525	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ANFP_RS04530	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ANFP_RS04535	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ANFP_RS04540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ANFP_RS04575	COG0432	Pfam Uncharacterised protein family UPF0047
ANFP_RS04585	COG1193	negative regulation of DNA recombination
ANFP_RS04590	COG0028	Belongs to the TPP enzyme family
ANFP_RS04600	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ANFP_RS04605	COG0688	phosphatidylethanolamine metabolic process
ANFP_RS04610	COG1183	phosphatidylcholine synthase activity
ANFP_RS04620	COG0589	response to stress
ANFP_RS04625	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ANFP_RS04630	COG1196	nuclear chromosome segregation
ANFP_RS04645	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ANFP_RS04675	COG0730	response to heat
ANFP_RS04685	COG0811	peptide transport
ANFP_RS04705	COG0402	S-adenosylhomocysteine deaminase activity
ANFP_RS04710	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ANFP_RS04755	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ANFP_RS04755	COG3608	succinylglutamate desuccinylase aspartoacylase
ANFP_RS04775	COG0746	molybdenum cofactor guanylyltransferase activity
ANFP_RS04815	COG0475	glutathione-regulated potassium exporter activity
ANFP_RS04820	COG1028	Short-chain dehydrogenase reductase Sdr
ANFP_RS04900	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ANFP_RS04900	COG2080	2 iron, 2 sulfur cluster binding
ANFP_RS04910	COG2814	Major facilitator Superfamily
ANFP_RS04915	COG0038	chloride channel
ANFP_RS04925	COG0583	DNA-binding transcription factor activity
ANFP_RS04975	COG1196	nuclear chromosome segregation
ANFP_RS04980	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ANFP_RS05000	COG1484	DNA-dependent DNA replication
ANFP_RS05015	COG3344	reverse transcriptase
ANFP_RS05065	COG0420	3'-5' exonuclease activity
ANFP_RS05070	COG0419	ATPase involved in DNA repair
ANFP_RS05130	COG2217	Heavy metal translocating P-type atpase
ANFP_RS05135	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ANFP_RS05155	COG0789	Transcriptional regulator
ANFP_RS05175	COG2608	mercury ion transmembrane transporter activity
ANFP_RS05185	COG0789	Transcriptional regulator
ANFP_RS05225	COG1595	DNA-templated transcription, initiation
ANFP_RS05255	COG2995	paraquat-inducible protein a
ANFP_RS05275	COG0531	amino acid
ANFP_RS05280	COG0076	glutamate decarboxylase activity
ANFP_RS05285	COG1484	DNA-dependent DNA replication
ANFP_RS05315	COG2814	Major facilitator Superfamily
ANFP_RS05325	COG4584	PFAM Integrase catalytic
ANFP_RS05330	COG1484	DNA-dependent DNA replication
ANFP_RS05340	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ANFP_RS05390	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ANFP_RS05440	COG1230	cation diffusion facilitator family transporter
ANFP_RS05445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ANFP_RS05445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ANFP_RS05455	COG0477	Major facilitator Superfamily
ANFP_RS05605	COG2378	regulation of single-species biofilm formation
ANFP_RS05610	COG0640	Transcriptional regulator
ANFP_RS05615	COG0697	spore germination
ANFP_RS05695	COG1064	alcohol dehydrogenase
ANFP_RS05700	COG0504	CTP synthase activity
ANFP_RS05705	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ANFP_RS05710	COG0148	phosphopyruvate hydratase activity
ANFP_RS05715	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ANFP_RS05720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ANFP_RS05730	COG0322	excinuclease ABC activity
ANFP_RS05755	COG3189	MarR family transcriptional regulator
ANFP_RS05770	COG1017	nitric oxide dioxygenase activity
ANFP_RS05770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ANFP_RS05775	COG1566	PFAM secretion protein HlyD family protein
ANFP_RS05780	COG1538	Outer membrane efflux protein
ANFP_RS05785	COG2814	Major facilitator Superfamily
ANFP_RS05790	COG0583	DNA-binding transcription factor activity
ANFP_RS05815	COG2161	toxin-antitoxin pair type II binding
ANFP_RS05830	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ANFP_RS05845	COG0384	phenazine biosynthesis protein PhzF
ANFP_RS05865	COG1247	-acetyltransferase
ANFP_RS05890	COG0300	oxidoreductase activity
ANFP_RS05920	COG0393	Putative heavy-metal-binding
ANFP_RS05930	COG2026	Addiction module toxin, RelE StbE family
ANFP_RS05940	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ANFP_RS05945	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ANFP_RS05955	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ANFP_RS05960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ANFP_RS05970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ANFP_RS05975	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ANFP_RS05980	COG0287	Prephenate dehydrogenase
ANFP_RS05985	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ANFP_RS05990	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ANFP_RS06000	COG0776	regulation of translation
ANFP_RS06005	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ANFP_RS06010	COG0284	orotidine-5'-phosphate decarboxylase activity
ANFP_RS06015	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ANFP_RS06020	COG0544	peptidyl-prolyl cis-trans isomerase activity
ANFP_RS06030	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ANFP_RS06035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ANFP_RS06055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ANFP_RS06060	COG0671	phosphoesterase, PA-phosphatase related
ANFP_RS06085	COG2915	High frequency lysogenization protein hflD homolog
ANFP_RS06090	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ANFP_RS06095	COG0024	Methionine aminopeptidase
ANFP_RS06100	COG1489	DNA binding
ANFP_RS06105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ANFP_RS06115	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ANFP_RS06125	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ANFP_RS06130	COG2137	regulation of response to DNA damage stimulus
ANFP_RS06175	COG0741	lytic transglycosylase activity
ANFP_RS06175	COG1196	nuclear chromosome segregation
ANFP_RS06175	COG0739	heme binding
ANFP_RS06180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ANFP_RS06195	COG0488	(ABC) transporter
ANFP_RS06200	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ANFP_RS06225	COG1294	oxidase, subunit
ANFP_RS06250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ANFP_RS06265	COG2943	transferase activity, transferring hexosyl groups
ANFP_RS06265	COG3416	Protein conserved in bacteria
ANFP_RS06275	COG2363	Small membrane protein
ANFP_RS06320	COG0616	signal peptide processing
ANFP_RS06325	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ANFP_RS06330	COG0314	molybdopterin synthase activity
ANFP_RS06335	COG1666	GTP binding
ANFP_RS06345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ANFP_RS06350	COG0509	glycine decarboxylation via glycine cleavage system
ANFP_RS06355	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ANFP_RS06360	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ANFP_RS06365	COG1132	(ABC) transporter
ANFP_RS06370	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ANFP_RS06375	COG0450	alkyl hydroperoxide reductase
ANFP_RS06385	COG0613	PHP domain protein
ANFP_RS06390	COG0628	permease
ANFP_RS06410	COG0084	hydrolase, TatD family'
ANFP_RS06415	COG0321	lipoyl(octanoyl) transferase activity
ANFP_RS06415	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ANFP_RS06430	COG0776	regulation of translation
ANFP_RS06475	COG3846	protein secretion by the type IV secretion system
ANFP_RS06510	COG0393	Putative heavy-metal-binding
ANFP_RS06530	COG3451	type IV secretory pathway VirB4
ANFP_RS06535	COG5268	conjugation
ANFP_RS06550	COG4962	Type ii secretion system protein e
ANFP_RS06665	COG0776	regulation of translation
ANFP_RS06680	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ANFP_RS06700	COG1215	transferase activity, transferring glycosyl groups
ANFP_RS06810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ANFP_RS06835	COG0210	DNA helicase
ANFP_RS06855	COG1754	DNA topoisomerase type I activity
ANFP_RS06855	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ANFP_RS06965	COG1285	pathogenesis
ANFP_RS06970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ANFP_RS07005	COG4680	protein conserved in bacteria
ANFP_RS07035	COG4988	ABC transporter
ANFP_RS07040	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ANFP_RS07050	COG0354	folic acid binding
ANFP_RS07060	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ANFP_RS07075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANFP_RS07080	COG0481	GTPase activity
ANFP_RS07085	COG0681	Belongs to the peptidase S26 family
ANFP_RS07095	COG0571	ribonuclease III activity
ANFP_RS07100	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ANFP_RS07105	COG1381	Involved in DNA repair and RecF pathway recombination
ANFP_RS07110	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ANFP_RS07115	COG0736	holo-[acyl-carrier-protein] synthase activity
ANFP_RS07125	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ANFP_RS07125	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ANFP_RS07130	COG0037	tRNA processing
ANFP_RS07135	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ANFP_RS07200	COG0438	transferase activity, transferring glycosyl groups
ANFP_RS07215	COG1230	cation diffusion facilitator family transporter
ANFP_RS07230	COG0513	Belongs to the DEAD box helicase family
ANFP_RS07245	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ANFP_RS07250	COG0573	inorganic phosphate transmembrane transporter activity
ANFP_RS07255	COG0581	inorganic phosphate transmembrane transporter activity
ANFP_RS07260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ANFP_RS07265	COG0704	Plays a role in the regulation of phosphate uptake
ANFP_RS07280	COG0052	Belongs to the universal ribosomal protein uS2 family
ANFP_RS07285	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ANFP_RS07290	COG0528	UMP kinase activity
ANFP_RS07300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ANFP_RS07305	COG0575	Belongs to the CDS family
ANFP_RS07310	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ANFP_RS07330	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ANFP_RS07335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ANFP_RS07340	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ANFP_RS07345	COG0673	inositol 2-dehydrogenase activity
ANFP_RS07355	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ANFP_RS07360	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ANFP_RS07370	COG0825	malonyl-CoA metabolic process
ANFP_RS07375	COG0037	tRNA processing
ANFP_RS07385	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ANFP_RS07390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ANFP_RS07400	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ANFP_RS07405	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ANFP_RS07410	COG1166	arginine decarboxylase activity
ANFP_RS07455	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ANFP_RS07480	COG0811	peptide transport
ANFP_RS07505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ANFP_RS07510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ANFP_RS07515	COG1120	ATPase activity
ANFP_RS07525	COG0725	ABC transporter, periplasmic molybdate-binding protein
ANFP_RS07535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ANFP_RS07550	COG0725	ABC transporter, periplasmic molybdate-binding protein
ANFP_RS07570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ANFP_RS07625	COG5420	small protein containing a coiled-coil domain
ANFP_RS07640	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ANFP_RS07645	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ANFP_RS07660	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ANFP_RS07670	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
ANFP_RS07700	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ANFP_RS07735	COG1104	cysteine desulfurase activity
ANFP_RS07740	COG5554	nitrogen fixation
ANFP_RS07750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ANFP_RS07755	COG0633	Ferredoxin
ANFP_RS07780	COG1012	belongs to the aldehyde dehydrogenase family
ANFP_RS07800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ANFP_RS07805	COG0438	transferase activity, transferring glycosyl groups
ANFP_RS07810	COG0438	transferase activity, transferring glycosyl groups
ANFP_RS07815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ANFP_RS07845	COG0438	transferase activity, transferring glycosyl groups
ANFP_RS07850	COG0670	Belongs to the BI1 family
ANFP_RS07875	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ANFP_RS07880	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ANFP_RS07885	COG1428	Deoxynucleoside kinase
ANFP_RS07895	COG0617	tRNA 3'-terminal CCA addition
ANFP_RS07895	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ANFP_RS07895	COG3620	sequence-specific DNA binding
ANFP_RS07905	COG0463	Glycosyl transferase, family 2
ANFP_RS07915	COG0519	Catalyzes the synthesis of GMP from XMP
ANFP_RS07915	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ANFP_RS07920	COG4691	Plasmid stability protein
ANFP_RS07925	COG1487	ribonuclease activity
ANFP_RS07940	COG0531	amino acid
ANFP_RS07945	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ANFP_RS07950	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ANFP_RS07950	COG3264	Mechanosensitive ion channel
ANFP_RS07965	COG0009	L-threonylcarbamoyladenylate synthase
ANFP_RS07970	COG1994	Peptidase M50
ANFP_RS07975	COG0180	Tryptophanyl-tRNA synthetase
ANFP_RS07980	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ANFP_RS07985	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ANFP_RS07990	COG0446	pyridine nucleotide-disulphide oxidoreductase
ANFP_RS07995	COG1187	pseudouridine synthase activity
ANFP_RS08015	COG2814	Major facilitator Superfamily
ANFP_RS08030	COG0148	phosphopyruvate hydratase activity
ANFP_RS08055	COG1105	Belongs to the carbohydrate kinase PfkB family
ANFP_RS08060	COG0280	phosphate acetyltransferase
ANFP_RS08065	COG0477	Major facilitator Superfamily
ANFP_RS08070	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ANFP_RS08075	COG0508	dehydrogenase complex catalyzes the overall conversion of
ANFP_RS08080	COG0022	dehydrogenase e1 component
ANFP_RS08085	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ANFP_RS08095	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ANFP_RS08100	COG0574	Belongs to the PEP-utilizing enzyme family
ANFP_RS08100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ANFP_RS08115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ANFP_RS08120	COG2171	N-acyltransferase activity
ANFP_RS08140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ANFP_RS08145	COG0402	S-adenosylhomocysteine deaminase activity
ANFP_RS08155	COG0791	NLP P60 protein
ANFP_RS08155	COG1388	LysM domain
ANFP_RS08180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ANFP_RS08195	COG1484	DNA-dependent DNA replication
ANFP_RS08200	COG4584	PFAM Integrase catalytic
ANFP_RS08245	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ANFP_RS08255	COG1216	Glycosyl transferase, family 2
ANFP_RS08280	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ANFP_RS08285	COG1028	Short-chain dehydrogenase reductase Sdr
ANFP_RS08300	COG2154	pterin-4-alpha-carbinolamine dehydratase
ANFP_RS08330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ANFP_RS08345	COG0587	DNA-directed DNA polymerase activity
ANFP_RS08355	COG0308	aminopeptidase N
ANFP_RS08375	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ANFP_RS08380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ANFP_RS08400	COG0424	maF-like protein
ANFP_RS08405	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ANFP_RS08410	COG1923	regulation of RNA biosynthetic process
ANFP_RS08415	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ANFP_RS08420	COG0330	HflC and HflK could
ANFP_RS08425	COG0330	HflC and HflK could
ANFP_RS08430	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ANFP_RS08455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ANFP_RS08460	COG1058	Belongs to the CinA family
ANFP_RS08460	COG1546	Belongs to the CinA family
ANFP_RS08470	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ANFP_RS08475	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ANFP_RS08485	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ANFP_RS08490	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ANFP_RS08505	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ANFP_RS08515	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ANFP_RS08520	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ANFP_RS08530	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ANFP_RS08535	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ANFP_RS08540	COG1295	ribonuclease BN
ANFP_RS08550	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ANFP_RS08555	COG0416	fatty acid biosynthetic process
ANFP_RS08560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ANFP_RS08565	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ANFP_RS08575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ANFP_RS08580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ANFP_RS08590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ANFP_RS08595	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ANFP_RS08625	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ANFP_RS08630	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ANFP_RS08635	COG0004	ammonium transporteR
ANFP_RS08640	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ANFP_RS08640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ANFP_RS08645	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ANFP_RS08655	COG0802	atpase or kinase
ANFP_RS08660	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ANFP_RS08665	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ANFP_RS08670	COG0105	UTP biosynthetic process
ANFP_RS08675	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ANFP_RS08690	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ANFP_RS08695	COG0124	histidyl-tRNA synthetase
ANFP_RS08710	COG1160	GTP binding
ANFP_RS08745	COG0730	response to heat
ANFP_RS08755	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ANFP_RS08775	COG1881	PFAM PEBP family protein
ANFP_RS08785	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ANFP_RS08810	COG0729	surface antigen
ANFP_RS08830	COG4654	Cytochrome c, class I
ANFP_RS08860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANFP_RS08870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ANFP_RS08880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ANFP_RS08895	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ANFP_RS08900	COG1469	GTP cyclohydrolase I activity
ANFP_RS08905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ANFP_RS08910	COG0142	geranyltranstransferase activity
ANFP_RS08920	COG2223	nitrite transmembrane transporter activity
ANFP_RS08930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ANFP_RS08935	COG1570	exodeoxyribonuclease VII activity
ANFP_RS08940	COG2010	Cytochrome c
ANFP_RS08940	COG4993	Dehydrogenase
ANFP_RS08950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ANFP_RS08955	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ANFP_RS08960	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ANFP_RS08965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ANFP_RS08985	COG0583	DNA-binding transcription factor activity
ANFP_RS08990	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ANFP_RS08995	COG2197	response regulator
ANFP_RS09005	COG3916	Acyl-homoserine-lactone synthase
ANFP_RS09075	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ANFP_RS09080	COG0456	acetyltransferase
ANFP_RS09110	COG2217	Heavy metal translocating P-type atpase
ANFP_RS09115	COG0436	Aminotransferase
ANFP_RS09125	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ANFP_RS09130	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ANFP_RS09135	COG0640	Transcriptional regulator
ANFP_RS09140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ANFP_RS09150	COG0187	DNA topoisomerase II activity
ANFP_RS09155	COG0642	Histidine kinase
ANFP_RS09240	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ANFP_RS09255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ANFP_RS09260	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ANFP_RS09265	COG1862	Preprotein translocase
ANFP_RS09270	COG0343	queuine tRNA-ribosyltransferase activity
ANFP_RS09275	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ANFP_RS09280	COG1253	flavin adenine dinucleotide binding
ANFP_RS09295	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ANFP_RS09305	COG0285	dihydrofolate synthase activity
ANFP_RS09310	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ANFP_RS09315	COG0159	tryptophan synthase activity
ANFP_RS09320	COG0133	tryptophan synthase activity
ANFP_RS09325	COG0135	phosphoribosylanthranilate isomerase activity
ANFP_RS09330	COG0101	tRNA pseudouridine synthase activity
ANFP_RS09340	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ANFP_RS09350	COG0746	molybdenum cofactor guanylyltransferase activity
ANFP_RS09355	COG1763	Mo-molybdopterin cofactor biosynthetic process
ANFP_RS09360	COG0303	'Molybdopterin
ANFP_RS09365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ANFP_RS09370	COG0616	signal peptide processing
ANFP_RS09385	COG0438	transferase activity, transferring glycosyl groups
ANFP_RS09415	COG0501	Belongs to the peptidase M48B family
ANFP_RS09420	COG0477	Major facilitator Superfamily
ANFP_RS09485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ANFP_RS09490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ANFP_RS09515	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ANFP_RS09520	COG0154	amidase activity
ANFP_RS09525	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ANFP_RS09560	COG3394	polysaccharide catabolic process
ANFP_RS09575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANFP_RS09580	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ANFP_RS09585	COG1657	PFAM Prenyltransferase squalene oxidase
ANFP_RS09590	COG1562	ergosterol biosynthetic process
ANFP_RS09595	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ANFP_RS09600	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ANFP_RS09625	COG0442	prolyl-tRNA aminoacylation
ANFP_RS09645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ANFP_RS09660	COG1692	metallophosphoesterase
ANFP_RS09665	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ANFP_RS09685	COG0768	penicillin binding
ANFP_RS09690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ANFP_RS09695	COG0193	aminoacyl-tRNA hydrolase activity
ANFP_RS09700	COG0012	GTP binding
ANFP_RS09710	COG0651	ATP synthesis coupled electron transport
ANFP_RS09715	COG0650	Formate hydrogenlyase subunit 4
ANFP_RS09725	COG0651	ATP synthesis coupled electron transport
ANFP_RS09730	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ANFP_RS09730	COG3261	NADH dehydrogenase
ANFP_RS09735	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANFP_RS09740	COG1850	ribulose-bisphosphate carboxylase activity
ANFP_RS09760	COG2824	Alkylphosphonate utilization operon protein PhnA
ANFP_RS09765	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ANFP_RS09800	COG0726	polysaccharide deacetylase
ANFP_RS09800	COG1649	PFAM Uncharacterised BCR, COG1649
ANFP_RS09810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ANFP_RS09815	COG0494	nUDIX hydrolase
ANFP_RS09825	COG1187	pseudouridine synthase activity
ANFP_RS09830	COG2957	Belongs to the agmatine deiminase family
ANFP_RS09835	COG0243	molybdopterin cofactor binding
ANFP_RS09860	COG0589	response to stress
ANFP_RS09865	COG2814	Major facilitator Superfamily
ANFP_RS09880	COG0210	DNA helicase
ANFP_RS09885	COG0268	Binds directly to 16S ribosomal RNA
ANFP_RS09890	COG3842	ATPase activity
ANFP_RS09905	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ANFP_RS09910	COG0514	ATP-dependent DNA helicase (RecQ)
ANFP_RS09915	COG1965	Belongs to the frataxin family
ANFP_RS09935	COG0795	lipopolysaccharide-transporting ATPase activity
ANFP_RS09940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ANFP_RS09955	COG0525	valine-tRNA ligase activity
ANFP_RS09960	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ANFP_RS09980	COG0412	Dienelactone hydrolase
ANFP_RS09985	COG1902	pentaerythritol trinitrate reductase activity
ANFP_RS10000	COG3152	Membrane
ANFP_RS10030	COG1530	ribonuclease E activity
ANFP_RS10035	COG0215	cysteine-tRNA ligase activity
ANFP_RS10040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ANFP_RS10055	COG1028	Short-chain dehydrogenase reductase Sdr
ANFP_RS10075	COG0745	RESPONSE REGULATOR receiver
ANFP_RS10080	COG2205	protein histidine kinase activity
ANFP_RS10090	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ANFP_RS10095	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ANFP_RS10100	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ANFP_RS10110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ANFP_RS10165	COG4953	penicillin-binding protein 1C
ANFP_RS10195	COG0138	bifunctional purine biosynthesis protein purh
ANFP_RS10200	COG0151	Belongs to the GarS family
ANFP_RS10205	COG0009	L-threonylcarbamoyladenylate synthase
ANFP_RS10210	COG0408	coproporphyrinogen oxidase activity
ANFP_RS10215	COG0167	dihydroorotate dehydrogenase activity
ANFP_RS10245	COG0811	peptide transport
ANFP_RS10260	COG0811	peptide transport
ANFP_RS10280	COG0477	Major facilitator Superfamily
ANFP_RS10285	COG3624	Phosphonate C-P lyase system protein PhnG
ANFP_RS10290	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ANFP_RS10295	COG3626	phosphonate metabolism
ANFP_RS10300	COG3627	carbon phosphorus lyase activity
ANFP_RS10305	COG4107	phosphonate C-P lyase system protein PhnK
ANFP_RS10310	COG4778	phosphonate C-P lyase system protein PhnL
ANFP_RS10315	COG3454	Phosphonate metabolism
ANFP_RS10325	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ANFP_RS10330	COG2188	Transcriptional regulator
ANFP_RS10355	COG1131	(ABC) transporter
ANFP_RS10370	COG3511	phospholipase C
ANFP_RS10380	COG0811	peptide transport
ANFP_RS10395	COG4774	siderophore transport
ANFP_RS10435	COG2814	Major facilitator Superfamily
ANFP_RS10445	COG2062	phosphohistidine phosphatase, SixA
ANFP_RS10470	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ANFP_RS10475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ANFP_RS10490	COG0033	Phosphoglucomutase
ANFP_RS10510	COG3038	cytochrome b561
ANFP_RS10520	COG2814	Major facilitator Superfamily
ANFP_RS10525	COG0583	DNA-binding transcription factor activity
ANFP_RS10545	COG1193	negative regulation of DNA recombination
ANFP_RS10555	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ANFP_RS10565	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ANFP_RS10570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ANFP_RS10585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ANFP_RS10610	COG1686	Belongs to the peptidase S11 family
ANFP_RS10670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ANFP_RS10695	COG1196	nuclear chromosome segregation
ANFP_RS10715	COG2259	Doxx family
ANFP_RS10725	COG0655	NAD(P)H dehydrogenase (quinone) activity
ANFP_RS10755	COG1846	Transcriptional regulator
ANFP_RS10765	COG2353	YceI-like domain
ANFP_RS10790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ANFP_RS10810	COG0625	glutathione transferase activity
ANFP_RS10820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ANFP_RS10825	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ANFP_RS10875	COG0667	Aldo Keto reductase
ANFP_RS10890	COG1192	Involved in chromosome partitioning
ANFP_RS10895	COG1475	DNA binding
ANFP_RS10975	COG3701	Conjugal transfer protein
ANFP_RS10990	COG1850	ribulose-bisphosphate carboxylase activity
ANFP_RS11020	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ANFP_RS11025	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ANFP_RS11030	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ANFP_RS11045	COG1192	Involved in chromosome partitioning
ANFP_RS11065	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ANFP_RS11070	COG0009	L-threonylcarbamoyladenylate synthase
ANFP_RS11075	COG0129	dihydroxy-acid dehydratase activity
ANFP_RS11080	COG0418	dihydroorotase activity
ANFP_RS11115	COG0277	FAD linked oxidase domain protein
ANFP_RS11120	COG0277	FAD linked oxidase domain protein
ANFP_RS11125	COG0247	lactate metabolic process
ANFP_RS11130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ANFP_RS11135	COG3002	Belongs to the UPF0753 family
ANFP_RS11150	COG1151	hydroxylamine reductase activity
ANFP_RS11155	COG0633	Ferredoxin
ANFP_RS11155	COG0543	2 iron, 2 sulfur cluster binding
ANFP_RS11170	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ANFP_RS11180	COG0243	molybdopterin cofactor binding
ANFP_RS11185	COG2084	Dehydrogenase
ANFP_RS11200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANFP_RS11235	COG3451	type IV secretory pathway VirB4
ANFP_RS11255	COG4962	Type ii secretion system protein e
ANFP_RS11270	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ANFP_RS11275	COG3657	addiction module killer protein
ANFP_RS11295	COG4372	Transposase
ANFP_RS11420	COG3077	Addiction module antitoxin, RelB DinJ family
ANFP_RS11440	COG0776	regulation of translation
ANFP_RS11445	COG0776	regulation of translation
ANFP_RS11475	COG1002	Type II restriction enzyme, methylase subunits
ANFP_RS11485	COG1061	Type III restriction enzyme res subunit
ANFP_RS11490	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ANFP_RS11495	COG0028	Belongs to the TPP enzyme family
ANFP_RS11510	COG0328	RNA-DNA hybrid ribonuclease activity
ANFP_RS11555	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ANFP_RS11660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ANFP_RS11665	COG0393	Putative heavy-metal-binding
ANFP_RS11690	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ANFP_RS11700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ANFP_RS11785	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ANFP_RS11790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ANFP_RS11800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ANFP_RS11810	COG1272	protein, Hemolysin III
ANFP_RS11815	COG0860	N-Acetylmuramoyl-L-alanine amidase
ANFP_RS11825	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ANFP_RS11830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ANFP_RS11840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ANFP_RS11845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ANFP_RS11855	COG0640	Transcriptional regulator
ANFP_RS11905	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ANFP_RS11910	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ANFP_RS11925	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ANFP_RS11935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ANFP_RS11940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ANFP_RS11955	COG0606	chelatase, subunit chli
ANFP_RS11970	COG3344	reverse transcriptase
ANFP_RS11975	COG3344	reverse transcriptase
ANFP_RS11990	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ANFP_RS11995	COG4974	Belongs to the 'phage' integrase family
ANFP_RS12040	COG0454	-acetyltransferase
ANFP_RS12045	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANFP_RS12055	COG1484	DNA-dependent DNA replication
ANFP_RS12115	COG4372	Transposase
ANFP_RS12145	COG5001	Diguanylate cyclase
ANFP_RS12175	COG1846	Transcriptional regulator
ANFP_RS12185	COG2353	YceI-like domain
ANFP_RS12215	COG0776	regulation of translation
ANFP_RS12220	COG0776	regulation of translation
ANFP_RS12235	COG0393	Putative heavy-metal-binding
ANFP_RS12240	COG0477	Major facilitator Superfamily
ANFP_RS12255	COG0811	peptide transport
ANFP_RS12300	COG4372	Transposase
ANFP_RS12325	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ANFP_RS12330	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ANFP_RS12335	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ANFP_RS12345	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ANFP_RS12425	COG1484	DNA-dependent DNA replication
ANFP_RS12430	COG4584	PFAM Integrase catalytic
ANFP_RS12495	COG0789	Transcriptional regulator
ANFP_RS12525	COG1199	ATP-dependent helicase activity
ANFP_RS12535	COG0791	NLP P60 protein
ANFP_RS12550	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ANFP_RS12565	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ANFP_RS12570	COG0586	Pfam SNARE associated Golgi protein
ANFP_RS12585	COG0583	DNA-binding transcription factor activity
ANFP_RS12600	COG0123	including yeast histone deacetylase and acetoin utilization protein
ANFP_RS12650	COG0644	oxidoreductase
ANFP_RS12655	COG0095	Lipoate-protein ligase
ANFP_RS12665	COG0509	glycine decarboxylation via glycine cleavage system
ANFP_RS12675	COG0509	glycine decarboxylation via glycine cleavage system
ANFP_RS12680	COG2048	Heterodisulfide reductase, subunit B
ANFP_RS12710	COG2210	Belongs to the sulfur carrier protein TusA family
ANFP_RS12715	COG0425	Belongs to the sulfur carrier protein TusA family
ANFP_RS12720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ANFP_RS12725	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ANFP_RS12735	COG0315	cyclic pyranopterin monophosphate synthase activity
ANFP_RS12740	COG1077	Cell shape determining protein MreB Mrl
ANFP_RS12745	COG1792	Involved in formation and maintenance of cell shape
ANFP_RS12755	COG0768	penicillin binding
ANFP_RS12760	COG0772	Belongs to the SEDS family
ANFP_RS12765	COG1686	Belongs to the peptidase S11 family
ANFP_RS12775	COG0321	lipoyl(octanoyl) transferase activity
ANFP_RS12780	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ANFP_RS12830	COG0751	glycine-tRNA ligase activity
ANFP_RS12835	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ANFP_RS12845	COG0189	ligase activity
ANFP_RS12865	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ANFP_RS12895	COG0625	glutathione transferase activity
ANFP_RS12900	COG1733	regulation of RNA biosynthetic process
ANFP_RS12905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ANFP_RS12945	COG1131	(ABC) transporter
ANFP_RS12965	COG0776	regulation of translation
ANFP_RS12970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ANFP_RS12970	COG0072	phenylalanine-tRNA ligase activity
ANFP_RS12975	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ANFP_RS12980	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ANFP_RS12985	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ANFP_RS12990	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ANFP_RS12995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ANFP_RS13005	COG1007	ATP synthesis coupled electron transport
ANFP_RS13020	COG0713	ATP synthesis coupled electron transport
ANFP_RS13030	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANFP_RS13035	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ANFP_RS13040	COG1034	ATP synthesis coupled electron transport
ANFP_RS13050	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ANFP_RS13055	COG0649	NAD binding
ANFP_RS13060	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANFP_RS13065	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANFP_RS13070	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANFP_RS13080	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ANFP_RS13085	COG0149	triose-phosphate isomerase activity
ANFP_RS13090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ANFP_RS13095	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ANFP_RS13100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ANFP_RS13105	COG0312	modulator of DNA gyrase
ANFP_RS13110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ANFP_RS13110	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ANFP_RS13115	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ANFP_RS13130	COG0477	Major facilitator Superfamily
ANFP_RS13170	COG1276	copper resistance
ANFP_RS13170	COG2372	response to copper ion
ANFP_RS13180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ANFP_RS13210	COG0717	Belongs to the dCTP deaminase family
ANFP_RS13215	COG0489	protein tyrosine kinase activity
ANFP_RS13225	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ANFP_RS13230	COG0484	heat shock protein binding
ANFP_RS13235	COG0443	Heat shock 70 kDa protein
ANFP_RS13240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ANFP_RS13245	COG1420	regulation of RNA biosynthetic process
ANFP_RS13250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ANFP_RS13255	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ANFP_RS13260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ANFP_RS13260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ANFP_RS13265	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ANFP_RS13270	COG0114	fumarate hydratase activity
ANFP_RS13295	COG0297	glycogen (starch) synthase activity
ANFP_RS13300	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ANFP_RS13310	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ANFP_RS13360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ANFP_RS13375	COG2204	response regulator
ANFP_RS13375	COG5564	TIM-barrel signal transduction protein
ANFP_RS13385	COG2204	response regulator
ANFP_RS13425	COG4964	Belongs to the GSP D family
ANFP_RS13475	COG0457	Tetratricopeptide repeat
ANFP_RS13505	COG0826	peptidase U32
ANFP_RS13510	COG0826	peptidase U32
ANFP_RS13515	COG3154	lipid carrier protein
ANFP_RS13535	COG1028	Short-chain dehydrogenase reductase Sdr
ANFP_RS13540	COG0723	plastoquinol--plastocyanin reductase activity
ANFP_RS13545	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ANFP_RS13550	COG2857	Cytochrome c1
ANFP_RS13575	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ANFP_RS13580	COG1534	Rna-binding protein
ANFP_RS13585	COG2967	ApaG domain
ANFP_RS13590	COG2226	methyltransferase
ANFP_RS13610	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ANFP_RS13625	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ANFP_RS13635	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ANFP_RS13650	COG2177	Part of the ABC transporter FtsEX involved in
ANFP_RS13655	COG2884	Cell division ATP-binding protein ftsE
ANFP_RS13660	COG0552	protein localization to endoplasmic reticulum
ANFP_RS13665	COG0742	ribosomal rna small subunit methyltransferase
ANFP_RS13670	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ANFP_RS13675	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ANFP_RS13680	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ANFP_RS13685	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ANFP_RS13690	COG2890	protein-(glutamine-N5) methyltransferase activity
ANFP_RS13695	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ANFP_RS13700	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ANFP_RS13710	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ANFP_RS13715	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ANFP_RS13725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ANFP_RS13750	COG1487	ribonuclease activity
ANFP_RS13765	COG0625	glutathione transferase activity
ANFP_RS13780	COG1484	DNA-dependent DNA replication
ANFP_RS13785	COG4584	PFAM Integrase catalytic
ANFP_RS13835	COG0393	Putative heavy-metal-binding
ANFP_RS13845	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ANFP_RS13855	COG0732	type I restriction modification DNA specificity domain
ANFP_RS13870	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ANFP_RS13890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ANFP_RS13955	COG0006	proline dipeptidase activity
ANFP_RS13970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ANFP_RS13975	COG0305	Participates in initiation and elongation during chromosome replication
ANFP_RS13980	COG0359	binds to the 23S rRNA
ANFP_RS13995	COG0360	Binds together with S18 to 16S ribosomal RNA
ANFP_RS14000	COG1472	Belongs to the glycosyl hydrolase 3 family
ANFP_RS14005	COG0531	amino acid
ANFP_RS14015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ANFP_RS14040	COG0363	glucosamine-6-phosphate deaminase activity
ANFP_RS14055	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ANFP_RS14060	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ANFP_RS14070	COG1449	Belongs to the glycosyl hydrolase 57 family
ANFP_RS14075	COG1940	carbohydrate kinase activity
ANFP_RS14080	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ANFP_RS14085	COG2733	membrane
ANFP_RS14095	COG0629	single-stranded DNA binding
ANFP_RS14110	COG3118	belongs to the thioredoxin family
ANFP_RS14115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANFP_RS14130	COG0335	large ribosomal subunit rRNA binding
ANFP_RS14135	COG0336	Belongs to the RNA methyltransferase TrmD family
ANFP_RS14140	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ANFP_RS14145	COG0228	four-way junction DNA binding
ANFP_RS14150	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ANFP_RS14155	COG0431	NADPH-dependent FMN reductase
ANFP_RS14170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ANFP_RS14180	COG1131	(ABC) transporter
ANFP_RS14185	COG0842	Transport permease protein
ANFP_RS14190	COG0842	Transport permease protein
ANFP_RS14215	COG0509	glycine decarboxylation via glycine cleavage system
ANFP_RS14245	COG0583	DNA-binding transcription factor activity
ANFP_RS14250	COG2210	Belongs to the sulfur carrier protein TusA family
ANFP_RS14260	COG0631	protein serine/threonine phosphatase activity
ANFP_RS14265	COG4245	von Willebrand factor, type A
ANFP_RS14275	COG1573	uracil-dna glycosylase
ANFP_RS14290	COG2336	PFAM SpoVT AbrB
ANFP_RS14305	COG2336	PFAM SpoVT AbrB
ANFP_RS14320	COG0488	(ABC) transporter
ANFP_RS14350	COG0142	geranyltranstransferase activity
ANFP_RS14365	COG3852	Histidine kinase
ANFP_RS14375	COG2308	Evidence 4 Homologs of previously reported genes of
ANFP_RS14390	COG2766	serine protein kinase
ANFP_RS14395	COG0004	ammonium transporteR
ANFP_RS14400	COG2718	Belongs to the UPF0229 family
ANFP_RS14405	COG2719	SpoVR family
ANFP_RS14415	COG0347	Belongs to the P(II) protein family
ANFP_RS14420	COG0004	ammonium transporteR
ANFP_RS14425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ANFP_RS14425	COG0519	Catalyzes the synthesis of GMP from XMP
ANFP_RS14440	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ANFP_RS14450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ANFP_RS14455	COG1686	Belongs to the peptidase S11 family
ANFP_RS14460	COG0166	Belongs to the GPI family
ANFP_RS14470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ANFP_RS14485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ANFP_RS14495	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ANFP_RS14500	COG1074	ATP-dependent DNA helicase activity
ANFP_RS14505	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ANFP_RS14550	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ANFP_RS14560	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ANFP_RS14570	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ANFP_RS14585	COG0424	maF-like protein
ANFP_RS14590	COG1530	ribonuclease E activity
ANFP_RS14595	COG2204	response regulator
ANFP_RS14605	COG2205	protein histidine kinase activity
ANFP_RS14615	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ANFP_RS14660	COG0438	transferase activity, transferring glycosyl groups
ANFP_RS14675	COG0175	sulfate reduction
ANFP_RS14680	COG2895	sulfate adenylyltransferase (ATP) activity
ANFP_RS14680	COG0529	Catalyzes the synthesis of activated sulfate
ANFP_RS14745	COG1132	(ABC) transporter
ANFP_RS14765	COG0444	Belongs to the ABC transporter superfamily
ANFP_RS14770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ANFP_RS14775	COG0601	transmembrane transport
ANFP_RS14800	COG2095	MarC family integral membrane protein
ANFP_RS14805	COG0039	L-malate dehydrogenase activity
ANFP_RS14820	COG0811	peptide transport
ANFP_RS14825	COG0848	biopolymer transport protein
ANFP_RS14840	COG1028	Short-chain dehydrogenase reductase Sdr
ANFP_RS14840	COG3321	synthase
ANFP_RS14840	COG0604	alcohol dehydrogenase
ANFP_RS14845	COG0156	8-amino-7-oxononanoate synthase activity
ANFP_RS14870	COG1194	a g-specific adenine glycosylase
ANFP_RS14880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ANFP_RS14885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ANFP_RS14895	COG1660	Displays ATPase and GTPase activities
ANFP_RS14900	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ANFP_RS14905	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ANFP_RS14905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ANFP_RS14905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ANFP_RS14925	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ANFP_RS14935	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ANFP_RS14960	COG3178	'Phosphotransferase
ANFP_RS14965	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ANFP_RS14970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ANFP_RS14975	COG0842	Transport permease protein
ANFP_RS14980	COG0271	Belongs to the BolA IbaG family
ANFP_RS14985	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ANFP_RS14990	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ANFP_RS14995	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ANFP_RS15005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ANFP_RS15010	COG0131	Imidazoleglycerol-phosphate dehydratase
ANFP_RS15015	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ANFP_RS15020	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ANFP_RS15025	COG0107	imidazoleglycerol-phosphate synthase activity
ANFP_RS15030	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ANFP_RS15030	COG0140	phosphoribosyl-ATP diphosphatase activity
ANFP_RS15035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ANFP_RS15040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ANFP_RS15045	COG0805	protein transport
ANFP_RS15050	COG1850	ribulose-bisphosphate carboxylase activity
ANFP_RS15085	COG0540	Belongs to the ATCase OTCase family
ANFP_RS15090	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ANFP_RS15095	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ANFP_RS15100	COG1678	Uncharacterized ACR, COG1678
ANFP_RS15105	COG0189	ligase activity
ANFP_RS15120	COG0316	Belongs to the HesB IscA family
ANFP_RS15125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ANFP_RS15130	COG0508	dehydrogenase complex catalyzes the overall conversion of
ANFP_RS15130	COG0022	dehydrogenase e1 component
ANFP_RS15135	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ANFP_RS15150	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ANFP_RS15155	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ANFP_RS15160	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ANFP_RS15180	COG0778	Nitroreductase
ANFP_RS15215	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ANFP_RS15220	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ANFP_RS15230	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ANFP_RS15235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ANFP_RS15240	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ANFP_RS15240	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ANFP_RS15245	COG1611	Belongs to the LOG family
ANFP_RS15255	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ANFP_RS15270	COG1555	photosystem II stabilization
ANFP_RS15275	COG0210	DNA helicase
ANFP_RS15295	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ANFP_RS15295	COG1796	DNA polymerase
ANFP_RS15310	COG1028	Short-chain dehydrogenase reductase Sdr
ANFP_RS15315	COG0723	plastoquinol--plastocyanin reductase activity
ANFP_RS15320	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ANFP_RS15330	COG1333	cytochrome c biogenesis protein
ANFP_RS15335	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ANFP_RS15380	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ANFP_RS15385	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ANFP_RS15390	COG0175	sulfate reduction
ANFP_RS15400	COG2895	sulfate adenylyltransferase (ATP) activity
ANFP_RS15425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ANFP_RS15445	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ANFP_RS15465	COG2814	Major facilitator Superfamily
ANFP_RS15470	COG0109	protoheme IX farnesyltransferase activity
ANFP_RS15480	COG4454	pyrroloquinoline quinone binding
ANFP_RS15495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ANFP_RS15500	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ANFP_RS15540	COG0326	Molecular chaperone. Has ATPase activity
ANFP_RS15550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ANFP_RS15565	COG1131	(ABC) transporter
ANFP_RS15640	COG1484	DNA-dependent DNA replication
ANFP_RS15645	COG4584	PFAM Integrase catalytic
ANFP_RS15690	COG1715	Restriction endonuclease
ANFP_RS15725	COG1196	nuclear chromosome segregation
ANFP_RS15765	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ANFP_RS15780	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ANFP_RS15785	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ANFP_RS15790	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ANFP_RS15795	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ANFP_RS15805	COG0356	it plays a direct role in the translocation of protons across the membrane
ANFP_RS15815	COG1475	DNA binding
ANFP_RS15825	COG0357	Ribosomal RNA small subunit methyltransferase G
ANFP_RS15830	COG0445	tRNA wobble uridine modification
ANFP_RS15845	COG0521	Mo-molybdopterin cofactor biosynthetic process
ANFP_RS15875	COG0655	NAD(P)H dehydrogenase (quinone) activity
ANFP_RS15925	COG1131	(ABC) transporter
ANFP_RS15930	COG2945	thiolester hydrolase activity
ANFP_RS15940	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ANFP_RS15945	COG1959	2 iron, 2 sulfur cluster binding
ANFP_RS15955	COG0134	indole-3-glycerol-phosphate synthase activity
ANFP_RS15960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ANFP_RS15975	COG0546	phosphoglycolate phosphatase activity
ANFP_RS15980	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ANFP_RS15995	COG0126	phosphoglycerate kinase activity
ANFP_RS16000	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ANFP_RS16005	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ANFP_RS16010	COG1494	fructose-1,6-bisphosphatase
ANFP_RS16015	COG0483	inositol monophosphate 1-phosphatase activity
ANFP_RS16025	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ANFP_RS16030	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ANFP_RS16035	COG1322	Protein conserved in bacteria
ANFP_RS16040	COG1970	mechanosensitive ion channel activity
ANFP_RS16050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ANFP_RS16055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ANFP_RS16065	COG1671	Belongs to the UPF0178 family
ANFP_RS16120	COG0165	Argininosuccinate lyase
ANFP_RS16135	COG1881	PFAM PEBP family protein
ANFP_RS16160	COG0247	lactate metabolic process
ANFP_RS16160	COG2181	nitrate reductase activity
ANFP_RS16170	COG0375	protein maturation
ANFP_RS16185	COG0409	Hydrogenase expression formation protein
ANFP_RS16200	COG0662	Cupin 2, conserved barrel domain protein
ANFP_RS16200	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ANFP_RS16225	COG0113	porphobilinogen synthase activity
ANFP_RS16235	COG0181	hydroxymethylbilane synthase activity
ANFP_RS16245	COG0537	adenosine 5'-monophosphoramidase activity
ANFP_RS16250	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ANFP_RS16255	COG0352	thiamine-phosphate diphosphorylase activity
ANFP_RS16260	COG0351	phosphomethylpyrimidine kinase
ANFP_RS16280	COG0509	glycine decarboxylation via glycine cleavage system
ANFP_RS16310	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ANFP_RS16315	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ANFP_RS16340	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ANFP_RS16355	COG1151	hydroxylamine reductase activity
ANFP_RS16360	COG0543	2 iron, 2 sulfur cluster binding
ANFP_RS16360	COG0633	Ferredoxin
ANFP_RS16380	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ANFP_RS16385	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ANFP_RS16405	COG2826	transposase and inactivated derivatives, IS30 family
ANFP_RS16505	COG2337	Toxic component of a toxin-antitoxin (TA) module
ANFP_RS16520	COG0583	DNA-binding transcription factor activity
ANFP_RS16525	COG2814	Major facilitator Superfamily
ANFP_RS16530	COG1538	Outer membrane efflux protein
ANFP_RS16535	COG1566	PFAM secretion protein HlyD family protein
ANFP_RS16540	COG1017	nitric oxide dioxygenase activity
ANFP_RS16540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ANFP_RS16550	COG1546	Belongs to the CinA family
ANFP_RS16550	COG1058	Belongs to the CinA family