locus-tag	class	description
GCD22_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GCD22_RS00010	COG0592	DNA-directed DNA polymerase activity
GCD22_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GCD22_RS00020	COG0187	DNA topoisomerase II activity
GCD22_RS00030	COG0493	'glutamate synthase
GCD22_RS00030	COG0543	2 iron, 2 sulfur cluster binding
GCD22_RS00035	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GCD22_RS00045	COG0850	regulation of cytokinetic process
GCD22_RS00050	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GCD22_RS00060	COG2922	Belongs to the Smg family
GCD22_RS00065	COG0758	DNA mediated transformation
GCD22_RS00075	COG0242	peptide deformylase activity
GCD22_RS00080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GCD22_RS00085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GCD22_RS00085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GCD22_RS00095	COG5000	phosphorelay sensor kinase activity
GCD22_RS00100	COG2204	response regulator
GCD22_RS00115	COG0277	FAD linked oxidase domain protein
GCD22_RS00120	COG0277	FAD linked oxidase domain protein
GCD22_RS00125	COG0247	lactate metabolic process
GCD22_RS00150	COG0521	Mo-molybdopterin cofactor biosynthetic process
GCD22_RS00170	COG4804	nuclease activity
GCD22_RS00195	COG0445	tRNA wobble uridine modification
GCD22_RS00200	COG0357	Ribosomal RNA small subunit methyltransferase G
GCD22_RS00220	COG0356	it plays a direct role in the translocation of protons across the membrane
GCD22_RS00230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GCD22_RS00235	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GCD22_RS00240	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GCD22_RS00245	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GCD22_RS00260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GCD22_RS00355	COG0789	Transcriptional regulator
GCD22_RS00375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GCD22_RS00375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCD22_RS00385	COG0477	Major facilitator Superfamily
GCD22_RS00410	COG3220	belongs to the UPF0276 family
GCD22_RS00425	COG4232	protein-disulfide reductase activity
GCD22_RS00505	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GCD22_RS00530	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GCD22_RS00545	COG0210	DNA helicase
GCD22_RS00555	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GCD22_RS00565	COG1611	Belongs to the LOG family
GCD22_RS00575	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GCD22_RS00580	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GCD22_RS00585	COG1333	cytochrome c biogenesis protein
GCD22_RS00590	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GCD22_RS00600	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GCD22_RS00640	COG2081	HI0933 family
GCD22_RS00650	COG0778	Nitroreductase
GCD22_RS00660	COG2814	Major facilitator Superfamily
GCD22_RS00670	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCD22_RS00675	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCD22_RS00680	COG0649	NAD binding
GCD22_RS00680	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCD22_RS00695	COG1034	ATP synthesis coupled electron transport
GCD22_RS00695	COG1034	ATP synthesis coupled electron transport
GCD22_RS00700	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GCD22_RS00715	COG0713	ATP synthesis coupled electron transport
GCD22_RS00720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GCD22_RS00735	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GCD22_RS00740	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GCD22_RS00745	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GCD22_RS00750	COG3300	MHYT domain
GCD22_RS00750	COG5001	Diguanylate cyclase
GCD22_RS00790	COG2885	chlorophyll binding
GCD22_RS00795	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GCD22_RS00800	COG0508	dehydrogenase complex catalyzes the overall conversion of
GCD22_RS00800	COG0022	dehydrogenase e1 component
GCD22_RS00815	COG0316	Belongs to the HesB IscA family
GCD22_RS00830	COG0189	ligase activity
GCD22_RS00835	COG1678	Uncharacterized ACR, COG1678
GCD22_RS00840	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GCD22_RS00845	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GCD22_RS00850	COG0540	Belongs to the ATCase OTCase family
GCD22_RS00880	COG0805	protein transport
GCD22_RS00885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GCD22_RS00890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GCD22_RS00895	COG0140	phosphoribosyl-ATP diphosphatase activity
GCD22_RS00895	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GCD22_RS00900	COG0107	imidazoleglycerol-phosphate synthase activity
GCD22_RS00905	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GCD22_RS00910	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GCD22_RS00915	COG0131	Imidazoleglycerol-phosphate dehydratase
GCD22_RS00920	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GCD22_RS00925	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GCD22_RS00930	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GCD22_RS00935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GCD22_RS00940	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GCD22_RS00945	COG0271	Belongs to the BolA IbaG family
GCD22_RS00950	COG0842	Transport permease protein
GCD22_RS00955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GCD22_RS00960	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GCD22_RS00970	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GCD22_RS00990	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GCD22_RS01000	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GCD22_RS01020	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GCD22_RS01020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GCD22_RS01020	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GCD22_RS01025	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GCD22_RS01030	COG1660	Displays ATPase and GTPase activities
GCD22_RS01045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GCD22_RS01055	COG1194	a g-specific adenine glycosylase
GCD22_RS01060	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GCD22_RS01075	COG2205	protein histidine kinase activity
GCD22_RS01085	COG2204	response regulator
GCD22_RS01090	COG0076	glutamate decarboxylase activity
GCD22_RS01095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCD22_RS01100	COG2062	phosphohistidine phosphatase, SixA
GCD22_RS01105	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GCD22_RS01110	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GCD22_RS01115	COG1127	ABC transporter
GCD22_RS01120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GCD22_RS01125	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GCD22_RS01140	COG1131	(ABC) transporter
GCD22_RS01145	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GCD22_RS01150	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GCD22_RS01160	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GCD22_RS01175	COG0018	arginyl-trna synthetase
GCD22_RS01180	COG1196	nuclear chromosome segregation
GCD22_RS01180	COG3264	Mechanosensitive ion channel
GCD22_RS01185	COG2814	Major facilitator Superfamily
GCD22_RS01190	COG0583	DNA-binding transcription factor activity
GCD22_RS01195	COG2890	protein-(glutamine-N5) methyltransferase activity
GCD22_RS01200	COG0708	Exodeoxyribonuclease III
GCD22_RS01210	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GCD22_RS01215	COG0625	glutathione transferase activity
GCD22_RS01225	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GCD22_RS01230	COG1047	Peptidyl-prolyl cis-trans
GCD22_RS01235	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GCD22_RS01240	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GCD22_RS01245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GCD22_RS01270	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GCD22_RS01275	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GCD22_RS01325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GCD22_RS01340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GCD22_RS01370	COG0741	lytic transglycosylase activity
GCD22_RS01370	COG0739	heme binding
GCD22_RS01370	COG1196	nuclear chromosome segregation
GCD22_RS01375	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GCD22_RS01385	COG2264	protein methyltransferase activity
GCD22_RS01390	COG0439	Biotin carboxylase
GCD22_RS01395	COG0511	ligase activity, forming carbon-carbon bonds
GCD22_RS01400	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GCD22_RS01415	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GCD22_RS01430	COG1181	Belongs to the D-alanine--D-alanine ligase family
GCD22_RS01435	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GCD22_RS01440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GCD22_RS01445	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GCD22_RS01450	COG0772	Belongs to the SEDS family
GCD22_RS01455	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GCD22_RS01460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GCD22_RS01465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GCD22_RS01485	COG0275	rRNA processing
GCD22_RS01490	COG2001	Belongs to the MraZ family
GCD22_RS01515	COG0625	glutathione transferase activity
GCD22_RS01520	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GCD22_RS01530	COG0653	protein targeting
GCD22_RS01535	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GCD22_RS01540	COG0494	nUDIX hydrolase
GCD22_RS01545	COG0463	Glycosyl transferase, family 2
GCD22_RS01555	COG0438	transferase activity, transferring glycosyl groups
GCD22_RS01585	COG1519	Transferase
GCD22_RS01590	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GCD22_RS01595	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GCD22_RS01600	COG3180	Ammonia monooxygenase
GCD22_RS01605	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GCD22_RS01610	COG1040	competence protein
GCD22_RS01615	COG0156	8-amino-7-oxononanoate synthase activity
GCD22_RS01620	COG0596	Alpha beta hydrolase
GCD22_RS01625	COG2226	methyltransferase
GCD22_RS01630	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GCD22_RS01635	COG0501	Belongs to the peptidase M48B family
GCD22_RS01645	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GCD22_RS01650	COG0390	transport system, permease component
GCD22_RS01655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GCD22_RS01680	COG1309	transcriptional regulator
GCD22_RS01685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GCD22_RS01695	COG1566	PFAM secretion protein HlyD family protein
GCD22_RS01705	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GCD22_RS01745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GCD22_RS01750	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GCD22_RS01755	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GCD22_RS01760	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GCD22_RS01770	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GCD22_RS01790	COG0735	belongs to the Fur family
GCD22_RS01795	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GCD22_RS01800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GCD22_RS01805	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GCD22_RS01810	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GCD22_RS01815	COG1671	Belongs to the UPF0178 family
GCD22_RS01825	COG0659	secondary active sulfate transmembrane transporter activity
GCD22_RS01830	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GCD22_RS01835	COG2226	methyltransferase
GCD22_RS01845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GCD22_RS01845	COG2813	Specifically methylates the guanine in position
GCD22_RS01850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GCD22_RS01860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GCD22_RS01865	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GCD22_RS01870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GCD22_RS01870	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GCD22_RS01885	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GCD22_RS01905	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GCD22_RS01930	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GCD22_RS01950	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GCD22_RS01955	COG0081	regulation of translation
GCD22_RS01960	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GCD22_RS01965	COG0222	ribosome binding
GCD22_RS01970	COG0085	RNA polymerase activity
GCD22_RS01975	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GCD22_RS01980	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GCD22_RS01985	COG0049	tRNA binding
GCD22_RS01990	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GCD22_RS01995	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GCD22_RS02000	COG0051	transcription antitermination factor activity, RNA binding
GCD22_RS02005	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GCD22_RS02010	COG0088	Forms part of the polypeptide exit tunnel
GCD22_RS02015	COG0089	rRNA binding
GCD22_RS02020	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GCD22_RS02025	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GCD22_RS02030	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GCD22_RS02040	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GCD22_RS02045	COG0255	Belongs to the universal ribosomal protein uL29 family
GCD22_RS02050	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GCD22_RS02055	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GCD22_RS02060	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GCD22_RS02065	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GCD22_RS02070	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GCD22_RS02075	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GCD22_RS02080	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GCD22_RS02085	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GCD22_RS02090	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GCD22_RS02095	COG1841	ribosomal large subunit assembly
GCD22_RS02100	COG0200	Binds to the 23S rRNA
GCD22_RS02105	COG0201	protein transport
GCD22_RS02110	COG0563	adenylate kinase activity
GCD22_RS02115	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GCD22_RS02120	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GCD22_RS02125	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GCD22_RS02130	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GCD22_RS02135	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GCD22_RS02140	COG0202	RNA polymerase activity
GCD22_RS02145	COG0203	ribosomal protein L17
GCD22_RS02155	COG0756	dUTP diphosphatase activity
GCD22_RS02160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GCD22_RS02165	COG2003	Belongs to the UPF0758 family
GCD22_RS02190	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GCD22_RS02205	COG0678	peroxiredoxin activity
GCD22_RS02205	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GCD22_RS02210	COG3830	Belongs to the UPF0237 family
GCD22_RS02210	COG0560	Phosphoserine phosphatase
GCD22_RS02215	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GCD22_RS02220	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GCD22_RS02225	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GCD22_RS02230	COG0585	pseudouridine synthase activity
GCD22_RS02240	COG2608	mercury ion transmembrane transporter activity
GCD22_RS02250	COG0492	ferredoxin-NADP+ reductase activity
GCD22_RS02255	COG0431	NADPH-dependent FMN reductase
GCD22_RS02270	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GCD22_RS02280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GCD22_RS02285	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GCD22_RS02295	COG1376	ErfK ybiS ycfS ynhG family protein
GCD22_RS02330	COG0779	Required for maturation of 30S ribosomal subunits
GCD22_RS02335	COG0195	Participates in both transcription termination and antitermination
GCD22_RS02340	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GCD22_RS02345	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GCD22_RS02350	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GCD22_RS02355	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GCD22_RS02360	COG1185	polyribonucleotide nucleotidyltransferase activity
GCD22_RS02365	COG0612	Peptidase, M16
GCD22_RS02370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GCD22_RS02375	COG2226	methyltransferase
GCD22_RS02380	COG0328	RNA-DNA hybrid ribonuclease activity
GCD22_RS02390	COG0346	lactoylglutathione lyase activity
GCD22_RS02395	COG0137	argininosuccinate synthase activity
GCD22_RS02400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GCD22_RS02405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GCD22_RS02420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GCD22_RS02430	COG1388	LysM domain
GCD22_RS02430	COG0741	lytic transglycosylase activity
GCD22_RS02475	COG2161	toxin-antitoxin pair type II binding
GCD22_RS02535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GCD22_RS02545	COG0538	isocitrate dehydrogenase activity
GCD22_RS02550	COG0045	succinate-CoA ligase (ADP-forming) activity
GCD22_RS02560	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GCD22_RS02570	COG0347	Belongs to the P(II) protein family
GCD22_RS02600	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
GCD22_RS02605	COG0235	Class ii aldolase
GCD22_RS02615	COG0242	peptide deformylase activity
GCD22_RS02620	COG1088	dTDP-glucose 4,6-dehydratase activity
GCD22_RS02645	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GCD22_RS02650	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GCD22_RS02660	COG2204	response regulator
GCD22_RS02670	COG2205	protein histidine kinase activity
GCD22_RS02675	COG0497	DNA recombination
GCD22_RS02680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GCD22_RS02695	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GCD22_RS02700	COG1466	dna polymerase III delta subunit
GCD22_RS02710	COG0495	leucyl-tRNA aminoacylation
GCD22_RS02715	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GCD22_RS02735	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GCD22_RS02760	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GCD22_RS02765	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GCD22_RS02765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GCD22_RS02770	COG0312	modulator of DNA gyrase
GCD22_RS02775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GCD22_RS02780	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GCD22_RS02785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GCD22_RS02790	COG0149	triose-phosphate isomerase activity
GCD22_RS02795	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GCD22_RS02805	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCD22_RS02810	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCD22_RS02815	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCD22_RS02820	COG0649	NAD binding
GCD22_RS02825	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GCD22_RS02835	COG1034	ATP synthesis coupled electron transport
GCD22_RS02840	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GCD22_RS02845	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCD22_RS02855	COG0713	ATP synthesis coupled electron transport
GCD22_RS02870	COG1007	ATP synthesis coupled electron transport
GCD22_RS02885	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GCD22_RS02890	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GCD22_RS02895	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GCD22_RS02900	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GCD22_RS02905	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GCD22_RS02910	COG0072	phenylalanine-tRNA ligase activity
GCD22_RS02915	COG0776	regulation of translation
GCD22_RS02955	COG4197	protein conserved in bacteria, prophage-related
GCD22_RS02965	COG1484	DNA-dependent DNA replication
GCD22_RS03025	COG3311	Transcriptional regulator
GCD22_RS03075	COG3657	addiction module killer protein
GCD22_RS03080	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GCD22_RS03095	COG4962	Type ii secretion system protein e
GCD22_RS03100	COG1598	PFAM Uncharacterised protein family UPF0150
GCD22_RS03120	COG3451	type IV secretory pathway VirB4
GCD22_RS03160	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GCD22_RS03165	COG3657	addiction module killer protein
GCD22_RS03180	COG3701	Conjugal transfer protein
GCD22_RS03220	COG0328	RNA-DNA hybrid ribonuclease activity
GCD22_RS03255	COG3002	Belongs to the UPF0753 family
GCD22_RS03260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GCD22_RS03265	COG0583	DNA-binding transcription factor activity
GCD22_RS03275	COG0418	dihydroorotase activity
GCD22_RS03335	COG1484	DNA-dependent DNA replication
GCD22_RS03340	COG4584	PFAM Integrase catalytic
GCD22_RS03350	COG1475	DNA binding
GCD22_RS03355	COG1192	Involved in chromosome partitioning
GCD22_RS03395	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GCD22_RS03405	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GCD22_RS03440	COG4115	mRNA cleavage
GCD22_RS03445	COG2161	toxin-antitoxin pair type II binding
GCD22_RS03450	COG4953	penicillin-binding protein 1C
GCD22_RS03490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GCD22_RS03495	COG0531	amino acid
GCD22_RS03565	COG4221	oxidoreductase activity
GCD22_RS03665	COG1278	Cold shock
GCD22_RS03670	COG2204	response regulator
GCD22_RS03675	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GCD22_RS03680	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GCD22_RS03685	COG3161	chorismate lyase activity
GCD22_RS03690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GCD22_RS03695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GCD22_RS03700	COG1702	phosphate starvation-inducible protein PhoH
GCD22_RS03710	COG4535	Mg2 and Co2 transporter CorC
GCD22_RS03715	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GCD22_RS03720	COG0312	modulator of DNA gyrase
GCD22_RS03745	COG0523	cobalamin synthesis protein
GCD22_RS03785	COG1121	(ABC) transporter
GCD22_RS03810	COG2860	membrane
GCD22_RS03825	COG2226	methyltransferase
GCD22_RS03830	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GCD22_RS03840	COG0066	3-isopropylmalate dehydratase activity
GCD22_RS03850	COG0259	pyridoxamine-phosphate oxidase activity
GCD22_RS03855	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GCD22_RS03865	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GCD22_RS03870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GCD22_RS03890	COG0109	protoheme IX farnesyltransferase activity
GCD22_RS03895	COG2814	Major facilitator Superfamily
GCD22_RS03900	COG1968	undecaprenyl-diphosphatase activity
GCD22_RS03905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GCD22_RS03915	COG0505	Belongs to the CarA family
GCD22_RS03925	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GCD22_RS03950	COG0589	response to stress
GCD22_RS03985	COG1187	pseudouridine synthase activity
GCD22_RS03995	COG0494	nUDIX hydrolase
GCD22_RS04000	COG0012	GTP binding
GCD22_RS04005	COG0193	aminoacyl-tRNA hydrolase activity
GCD22_RS04010	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GCD22_RS04015	COG0768	penicillin binding
GCD22_RS04040	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GCD22_RS04045	COG1280	lysine exporter protein (LysE YggA)
GCD22_RS04055	COG1335	isochorismatase
GCD22_RS04075	COG0589	response to stress
GCD22_RS04080	COG0442	prolyl-tRNA aminoacylation
GCD22_RS04120	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GCD22_RS04165	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GCD22_RS04170	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GCD22_RS04175	COG3852	Histidine kinase
GCD22_RS04180	COG2204	response regulator
GCD22_RS04195	COG1562	ergosterol biosynthetic process
GCD22_RS04200	COG1657	PFAM Prenyltransferase squalene oxidase
GCD22_RS04205	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GCD22_RS04210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GCD22_RS04220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GCD22_RS04245	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GCD22_RS04260	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GCD22_RS04265	COG0154	amidase activity
GCD22_RS04270	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GCD22_RS04285	COG0386	Belongs to the glutathione peroxidase family
GCD22_RS04295	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GCD22_RS04300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GCD22_RS04305	COG1845	cytochrome c oxidase, subunit III
GCD22_RS04320	COG0109	protoheme IX farnesyltransferase activity
GCD22_RS04345	COG0737	Belongs to the 5'-nucleotidase family
GCD22_RS04355	COG1333	cytochrome c biogenesis protein
GCD22_RS04365	COG3258	Cytochrome c
GCD22_RS04370	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GCD22_RS04390	COG0529	Catalyzes the synthesis of activated sulfate
GCD22_RS04390	COG2046	Belongs to the sulfate adenylyltransferase family
GCD22_RS04395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GCD22_RS04415	COG4942	peptidase
GCD22_RS04505	COG2273	Hydrolase Family 16
GCD22_RS04540	COG2161	toxin-antitoxin pair type II binding
GCD22_RS04545	COG4115	mRNA cleavage
GCD22_RS04555	COG1002	Type II restriction enzyme, methylase subunits
GCD22_RS04565	COG1061	Type III restriction enzyme res subunit
GCD22_RS04570	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GCD22_RS04615	COG0582	viral genome integration into host DNA
GCD22_RS04635	COG1686	Belongs to the peptidase S11 family
GCD22_RS04640	COG2814	Major facilitator Superfamily
GCD22_RS04645	COG1187	pseudouridine synthase activity
GCD22_RS04655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GCD22_RS04670	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GCD22_RS04675	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GCD22_RS04685	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GCD22_RS04695	COG1193	negative regulation of DNA recombination
GCD22_RS04700	COG0358	DNA primase activity
GCD22_RS04715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GCD22_RS04725	COG0308	aminopeptidase N
GCD22_RS04750	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GCD22_RS04755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GCD22_RS04760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GCD22_RS04765	COG1538	Outer membrane efflux protein
GCD22_RS04780	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GCD22_RS04785	COG1923	regulation of RNA biosynthetic process
GCD22_RS04790	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GCD22_RS04795	COG0330	HflC and HflK could
GCD22_RS04805	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GCD22_RS04840	COG2995	paraquat-inducible protein a
GCD22_RS04860	COG0616	signal peptide processing
GCD22_RS04865	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GCD22_RS04870	COG0314	molybdopterin synthase activity
GCD22_RS04875	COG1666	GTP binding
GCD22_RS04880	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GCD22_RS04890	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GCD22_RS04895	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GCD22_RS04900	COG0714	Associated with various cellular activities
GCD22_RS04915	COG1132	(ABC) transporter
GCD22_RS04920	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GCD22_RS04925	COG0450	alkyl hydroperoxide reductase
GCD22_RS04935	COG0613	PHP domain protein
GCD22_RS04940	COG0628	permease
GCD22_RS04955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GCD22_RS04960	COG0084	hydrolase, TatD family'
GCD22_RS04965	COG0321	lipoyl(octanoyl) transferase activity
GCD22_RS04965	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GCD22_RS04980	COG4988	ABC transporter
GCD22_RS04985	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GCD22_RS05005	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GCD22_RS05020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GCD22_RS05025	COG0481	GTPase activity
GCD22_RS05030	COG0681	Belongs to the peptidase S26 family
GCD22_RS05045	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GCD22_RS05050	COG1381	Involved in DNA repair and RecF pathway recombination
GCD22_RS05055	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GCD22_RS05060	COG0736	holo-[acyl-carrier-protein] synthase activity
GCD22_RS05070	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GCD22_RS05075	COG0037	tRNA processing
GCD22_RS05080	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GCD22_RS05100	COG1396	sequence-specific DNA binding
GCD22_RS05115	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GCD22_RS05120	COG0416	fatty acid biosynthetic process
GCD22_RS05125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GCD22_RS05130	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GCD22_RS05140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GCD22_RS05145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GCD22_RS05155	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GCD22_RS05210	COG0071	Belongs to the small heat shock protein (HSP20) family
GCD22_RS05280	COG3038	cytochrome b561
GCD22_RS05300	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GCD22_RS05340	COG1566	PFAM secretion protein HlyD family protein
GCD22_RS05345	COG1538	Outer membrane efflux protein
GCD22_RS05370	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GCD22_RS05375	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GCD22_RS05380	COG0004	ammonium transporteR
GCD22_RS05385	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GCD22_RS05385	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GCD22_RS05390	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GCD22_RS05395	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GCD22_RS05395	COG0517	IMP dehydrogenase activity
GCD22_RS05395	COG0617	tRNA 3'-terminal CCA addition
GCD22_RS05400	COG0802	atpase or kinase
GCD22_RS05405	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GCD22_RS05410	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GCD22_RS05420	COG1289	transmembrane transporter activity
GCD22_RS05430	COG1566	PFAM secretion protein HlyD family protein
GCD22_RS05435	COG0105	UTP biosynthetic process
GCD22_RS05440	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GCD22_RS05445	COG0457	Tetratricopeptide repeat
GCD22_RS05455	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GCD22_RS05460	COG0124	histidyl-tRNA synthetase
GCD22_RS05475	COG1160	GTP binding
GCD22_RS05520	COG1902	pentaerythritol trinitrate reductase activity
GCD22_RS05525	COG0418	dihydroorotase activity
GCD22_RS05545	COG3668	Plasmid stabilization system
GCD22_RS05550	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GCD22_RS05555	COG0670	Belongs to the BI1 family
GCD22_RS05570	COG1193	negative regulation of DNA recombination
GCD22_RS05575	COG0277	FAD linked oxidase domain protein
GCD22_RS05580	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GCD22_RS05585	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GCD22_RS05590	COG1428	Deoxynucleoside kinase
GCD22_RS05600	COG0617	tRNA 3'-terminal CCA addition
GCD22_RS05600	COG3620	sequence-specific DNA binding
GCD22_RS05600	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GCD22_RS05605	COG0617	tRNA 3'-terminal CCA addition
GCD22_RS05625	COG0463	Glycosyl transferase, family 2
GCD22_RS05635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GCD22_RS05635	COG0519	Catalyzes the synthesis of GMP from XMP
GCD22_RS05640	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GCD22_RS05645	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GCD22_RS05645	COG3264	Mechanosensitive ion channel
GCD22_RS05660	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GCD22_RS05665	COG0009	L-threonylcarbamoyladenylate synthase
GCD22_RS05670	COG1994	Peptidase M50
GCD22_RS05675	COG0180	Tryptophanyl-tRNA synthetase
GCD22_RS05680	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GCD22_RS05685	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GCD22_RS05690	COG0446	pyridine nucleotide-disulphide oxidoreductase
GCD22_RS05695	COG1187	pseudouridine synthase activity
GCD22_RS05705	COG5278	phosphoserine phosphatase activity
GCD22_RS05705	COG0840	transmembrane signaling receptor activity
GCD22_RS05710	COG0835	chemotaxis
GCD22_RS05710	COG0784	Response regulator, receiver
GCD22_RS05715	COG0840	transmembrane signaling receptor activity
GCD22_RS05730	COG0784	Response regulator, receiver
GCD22_RS05730	COG2198	Histidine kinase
GCD22_RS05730	COG0643	Histidine kinase
GCD22_RS05745	COG1360	Flagellar Motor Protein
GCD22_RS05755	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GCD22_RS05760	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GCD22_RS05780	COG1815	bacterial-type flagellum-dependent cell motility
GCD22_RS05785	COG1558	bacterial-type flagellum-dependent cell motility
GCD22_RS05790	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GCD22_RS05810	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GCD22_RS05815	COG1706	bacterial-type flagellum-dependent cell motility
GCD22_RS05820	COG1705	Flagellar rod assembly protein muramidase FlgJ
GCD22_RS05820	COG3951	Flagellar rod assembly protein muramidase FlgJ
GCD22_RS05840	COG0438	transferase activity, transferring glycosyl groups
GCD22_RS05840	COG1216	Glycosyl transferase, family 2
GCD22_RS05855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GCD22_RS05875	COG1516	flagellar protein fliS
GCD22_RS05890	COG3852	Histidine kinase
GCD22_RS05900	COG1677	Flagellar hook-basal body complex protein FliE
GCD22_RS05910	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GCD22_RS05955	COG1987	bacterial-type flagellum assembly
GCD22_RS05980	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GCD22_RS05995	COG1191	sigma factor activity
GCD22_RS06000	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GCD22_RS06015	COG3706	GGDEF domain
GCD22_RS06030	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GCD22_RS06050	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GCD22_RS06055	COG2201	protein-glutamate methylesterase activity
GCD22_RS06075	COG2257	FlhB HrpN YscU SpaS Family
GCD22_RS06090	COG2915	High frequency lysogenization protein hflD homolog
GCD22_RS06095	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GCD22_RS06100	COG0024	Methionine aminopeptidase
GCD22_RS06105	COG1489	DNA binding
GCD22_RS06110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GCD22_RS06120	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GCD22_RS06125	COG1058	Belongs to the CinA family
GCD22_RS06125	COG1546	Belongs to the CinA family
GCD22_RS06130	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GCD22_RS06135	COG2137	regulation of response to DNA damage stimulus
GCD22_RS06170	COG5001	Diguanylate cyclase
GCD22_RS06170	COG3300	MHYT domain
GCD22_RS06195	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GCD22_RS06210	COG0488	(ABC) transporter
GCD22_RS06220	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GCD22_RS06230	COG1294	oxidase, subunit
GCD22_RS06235	COG1271	oxidase subunit
GCD22_RS06275	COG2943	transferase activity, transferring hexosyl groups
GCD22_RS06290	COG2363	Small membrane protein
GCD22_RS06300	COG0477	Major facilitator Superfamily
GCD22_RS06305	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GCD22_RS06310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GCD22_RS06310	COG0574	Belongs to the PEP-utilizing enzyme family
GCD22_RS06325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GCD22_RS06330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GCD22_RS06340	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GCD22_RS06350	COG2188	Transcriptional regulator
GCD22_RS06355	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GCD22_RS06355	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
GCD22_RS06360	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
GCD22_RS06365	COG3454	Phosphonate metabolism
GCD22_RS06370	COG4778	phosphonate C-P lyase system protein PhnL
GCD22_RS06375	COG4107	phosphonate C-P lyase system protein PhnK
GCD22_RS06380	COG3627	carbon phosphorus lyase activity
GCD22_RS06385	COG3626	phosphonate metabolism
GCD22_RS06390	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
GCD22_RS06400	COG2271	Major facilitator Superfamily
GCD22_RS06435	COG0811	peptide transport
GCD22_RS06470	COG1070	Carbohydrate kinase
GCD22_RS06475	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GCD22_RS06480	COG1196	nuclear chromosome segregation
GCD22_RS06490	COG1266	CAAX protease self-immunity
GCD22_RS06495	COG1131	(ABC) transporter
GCD22_RS06505	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GCD22_RS06510	COG2885	chlorophyll binding
GCD22_RS06520	COG0477	Major facilitator Superfamily
GCD22_RS06525	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GCD22_RS06535	COG1598	PFAM Uncharacterised protein family UPF0150
GCD22_RS06550	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GCD22_RS06555	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GCD22_RS06560	COG1166	arginine decarboxylase activity
GCD22_RS06580	COG0179	Fumarylacetoacetate (FAA) hydrolase
GCD22_RS06605	COG0438	transferase activity, transferring glycosyl groups
GCD22_RS06610	COG3100	YcgL domain-containing protein
GCD22_RS06610	COG0561	phosphatase activity
GCD22_RS06620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GCD22_RS06640	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GCD22_RS06650	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GCD22_RS06655	COG1570	exodeoxyribonuclease VII activity
GCD22_RS06660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GCD22_RS06675	COG2223	nitrite transmembrane transporter activity
GCD22_RS06685	COG0142	geranyltranstransferase activity
GCD22_RS06690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GCD22_RS06695	COG1469	GTP cyclohydrolase I activity
GCD22_RS06700	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GCD22_RS06715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GCD22_RS06725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GCD22_RS06760	COG2027	D-alanyl-D-alanine carboxypeptidase
GCD22_RS06775	COG0729	surface antigen
GCD22_RS06800	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GCD22_RS06805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GCD22_RS06815	COG3220	belongs to the UPF0276 family
GCD22_RS06835	COG4232	protein-disulfide reductase activity
GCD22_RS06850	COG2814	Major facilitator Superfamily
GCD22_RS06860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GCD22_RS06860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCD22_RS06875	COG2226	methyltransferase
GCD22_RS06915	COG0393	Putative heavy-metal-binding
GCD22_RS07030	COG1271	oxidase subunit
GCD22_RS07060	COG0509	glycine decarboxylation via glycine cleavage system
GCD22_RS07065	COG0038	chloride channel
GCD22_RS07070	COG3247	response to pH
GCD22_RS07085	COG0583	DNA-binding transcription factor activity
GCD22_RS07095	COG0583	DNA-binding transcription factor activity
GCD22_RS07125	COG3302	dmso reductase anchor subunit
GCD22_RS07130	COG0437	4 iron, 4 sulfur cluster binding
GCD22_RS07135	COG0243	molybdopterin cofactor binding
GCD22_RS07180	COG2337	Toxic component of a toxin-antitoxin (TA) module
GCD22_RS07190	COG2718	Belongs to the UPF0229 family
GCD22_RS07225	COG0675	Transposase, IS605 OrfB family
GCD22_RS07420	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GCD22_RS07425	COG1140	nitrate reductase beta subunit
GCD22_RS07430	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GCD22_RS07435	COG2181	nitrate reductase activity
GCD22_RS07475	COG0509	glycine decarboxylation via glycine cleavage system
GCD22_RS07485	COG3189	MarR family transcriptional regulator
GCD22_RS07520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GCD22_RS07550	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GCD22_RS07555	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GCD22_RS07570	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GCD22_RS07605	COG0583	DNA-binding transcription factor activity
GCD22_RS07615	COG0166	Belongs to the GPI family
GCD22_RS07760	COG4581	dead DEAH box helicase
GCD22_RS07780	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GCD22_RS07865	COG2826	transposase and inactivated derivatives, IS30 family
GCD22_RS07890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GCD22_RS07895	COG1278	Cold shock
GCD22_RS08065	COG2200	EAL domain
GCD22_RS08065	COG2199	diguanylate cyclase activity
GCD22_RS08085	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GCD22_RS08125	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GCD22_RS08160	COG2226	methyltransferase
GCD22_RS08175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCD22_RS08175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GCD22_RS08185	COG2814	Major facilitator Superfamily
GCD22_RS08200	COG4232	protein-disulfide reductase activity
GCD22_RS08220	COG3220	belongs to the UPF0276 family
GCD22_RS08235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GCD22_RS08360	COG2827	Endonuclease containing a URI domain
GCD22_RS08385	COG2814	Major facilitator Superfamily
GCD22_RS08395	COG2079	MmgE PrpD family protein
GCD22_RS08405	COG0583	DNA-binding transcription factor activity
GCD22_RS08415	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GCD22_RS08460	COG0210	DNA helicase
GCD22_RS08505	COG2204	response regulator
GCD22_RS08555	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GCD22_RS08570	COG0298	carbon dioxide binding
GCD22_RS08575	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GCD22_RS08590	COG0375	protein maturation
GCD22_RS08595	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GCD22_RS08625	COG3561	AntA/AntB antirepressor
GCD22_RS08670	COG0675	Transposase, IS605 OrfB family
GCD22_RS08795	COG5654	RES domain protein
GCD22_RS08815	COG0776	regulation of translation
GCD22_RS08900	COG3451	type IV secretory pathway VirB4
GCD22_RS08940	COG2948	multi-organism process
GCD22_RS08955	COG4964	Belongs to the GSP D family
GCD22_RS08970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GCD22_RS09005	COG0210	DNA helicase
GCD22_RS09025	COG0629	single-stranded DNA binding
GCD22_RS09040	COG0675	Transposase, IS605 OrfB family
GCD22_RS09070	COG0419	ATPase involved in DNA repair
GCD22_RS09200	COG2826	transposase and inactivated derivatives, IS30 family
GCD22_RS09215	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GCD22_RS09240	COG1475	DNA binding
GCD22_RS09310	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GCD22_RS09310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GCD22_RS09415	COG0583	DNA-binding transcription factor activity
GCD22_RS09420	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GCD22_RS09425	COG3002	Belongs to the UPF0753 family
GCD22_RS09450	COG0789	Transcriptional regulator
GCD22_RS09485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GCD22_RS09485	COG0574	Belongs to the PEP-utilizing enzyme family
GCD22_RS09490	COG0730	response to heat
GCD22_RS09500	COG3300	MHYT domain
GCD22_RS09500	COG5001	Diguanylate cyclase
GCD22_RS09515	COG2814	Major facilitator Superfamily
GCD22_RS09535	COG1028	Short-chain dehydrogenase reductase Sdr
GCD22_RS09600	COG3550	peptidyl-serine autophosphorylation
GCD22_RS09610	COG4453	Protein conserved in bacteria
GCD22_RS09635	COG0842	Transport permease protein
GCD22_RS09640	COG0842	Transport permease protein
GCD22_RS09645	COG1131	(ABC) transporter
GCD22_RS09655	COG1538	Outer membrane efflux protein
GCD22_RS09670	COG1595	DNA-templated transcription, initiation
GCD22_RS09690	COG1294	oxidase, subunit
GCD22_RS09695	COG1271	oxidase subunit
GCD22_RS09720	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GCD22_RS09725	COG0022	dehydrogenase e1 component
GCD22_RS09730	COG0508	dehydrogenase complex catalyzes the overall conversion of
GCD22_RS09735	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GCD22_RS09740	COG0280	phosphate acetyltransferase
GCD22_RS09745	COG1105	Belongs to the carbohydrate kinase PfkB family
GCD22_RS09760	COG0148	phosphopyruvate hydratase activity
GCD22_RS09765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GCD22_RS09770	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GCD22_RS09775	COG2814	Major facilitator Superfamily
GCD22_RS09785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GCD22_RS09795	COG1271	oxidase subunit
GCD22_RS09830	COG3306	glycosyltransferase involved in LPS biosynthesis
GCD22_RS09890	COG0438	transferase activity, transferring glycosyl groups
GCD22_RS09910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GCD22_RS09915	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GCD22_RS09920	COG0037	tRNA processing
GCD22_RS09925	COG0825	malonyl-CoA metabolic process
GCD22_RS09935	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GCD22_RS09955	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GCD22_RS09960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GCD22_RS09965	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GCD22_RS09985	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GCD22_RS09990	COG0575	Belongs to the CDS family
GCD22_RS09995	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GCD22_RS10005	COG0528	UMP kinase activity
GCD22_RS10010	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GCD22_RS10015	COG0052	Belongs to the universal ribosomal protein uS2 family
GCD22_RS10030	COG0704	Plays a role in the regulation of phosphate uptake
GCD22_RS10035	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GCD22_RS10040	COG5002	protein histidine kinase activity
GCD22_RS10050	COG0513	Belongs to the DEAD box helicase family
GCD22_RS10055	COG0667	Aldo Keto reductase
GCD22_RS10060	COG0482	sulfurtransferase activity
GCD22_RS10075	COG0443	Heat shock 70 kDa protein
GCD22_RS10080	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GCD22_RS10090	COG0822	iron-sulfur transferase activity
GCD22_RS10095	COG1104	cysteine desulfurase activity
GCD22_RS10100	COG1959	2 iron, 2 sulfur cluster binding
GCD22_RS10105	COG1045	serine acetyltransferase
GCD22_RS10125	COG2917	probably involved in intracellular septation
GCD22_RS10130	COG2350	Protein conserved in bacteria
GCD22_RS10140	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GCD22_RS10140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GCD22_RS10150	COG0129	dihydroxy-acid dehydratase activity
GCD22_RS10155	COG0628	permease
GCD22_RS10160	COG0281	malic enzyme
GCD22_RS10165	COG0254	rRNA binding
GCD22_RS10195	COG0577	efflux transmembrane transporter activity
GCD22_RS10220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GCD22_RS10240	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GCD22_RS10245	COG1127	ABC transporter
GCD22_RS10250	COG0163	prenyltransferase activity
GCD22_RS10255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GCD22_RS10285	COG4636	protein conserved in cyanobacteria
GCD22_RS10315	COG2226	methyltransferase
GCD22_RS10340	COG0640	Transcriptional regulator
GCD22_RS10355	COG0210	DNA helicase
GCD22_RS10360	COG0268	Binds directly to 16S ribosomal RNA
GCD22_RS10375	COG3842	ATPase activity
GCD22_RS10380	COG1178	ABC-type Fe3 transport system permease component
GCD22_RS10390	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GCD22_RS10395	COG0514	ATP-dependent DNA helicase (RecQ)
GCD22_RS10400	COG1965	Belongs to the frataxin family
GCD22_RS10425	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GCD22_RS10435	COG0795	lipopolysaccharide-transporting ATPase activity
GCD22_RS10440	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GCD22_RS10460	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GCD22_RS10480	COG0412	Dienelactone hydrolase
GCD22_RS10485	COG1902	pentaerythritol trinitrate reductase activity
GCD22_RS10525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GCD22_RS10565	COG3220	belongs to the UPF0276 family
GCD22_RS10575	COG4232	protein-disulfide reductase activity
GCD22_RS10590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GCD22_RS10605	COG1595	DNA-templated transcription, initiation
GCD22_RS10620	COG2210	Belongs to the sulfur carrier protein TusA family
GCD22_RS10625	COG0425	Belongs to the sulfur carrier protein TusA family
GCD22_RS10645	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GCD22_RS10660	COG0776	regulation of translation
GCD22_RS10665	COG0776	regulation of translation
GCD22_RS10680	COG5002	protein histidine kinase activity
GCD22_RS10680	COG3447	MASE1 domain protein
GCD22_RS10680	COG5001	Diguanylate cyclase
GCD22_RS10690	COG2200	EAL domain
GCD22_RS10690	COG2199	diguanylate cyclase activity
GCD22_RS10690	COG2203	Gaf domain
GCD22_RS10725	COG0697	spore germination
GCD22_RS10735	COG0546	phosphoglycolate phosphatase activity
GCD22_RS10745	COG1530	ribonuclease E activity
GCD22_RS10750	COG0215	cysteine-tRNA ligase activity
GCD22_RS10755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GCD22_RS10765	COG0415	Belongs to the DNA photolyase family
GCD22_RS10785	COG1028	Short-chain dehydrogenase reductase Sdr
GCD22_RS10825	COG0730	response to heat
GCD22_RS10835	COG0326	Molecular chaperone. Has ATPase activity
GCD22_RS10840	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GCD22_RS10850	COG0519	Catalyzes the synthesis of GMP from XMP
GCD22_RS10880	COG0628	permease
GCD22_RS10990	COG1271	oxidase subunit
GCD22_RS10995	COG1294	oxidase, subunit
GCD22_RS11000	COG0446	pyridine nucleotide-disulphide oxidoreductase
GCD22_RS11010	COG3223	Belongs to the PsiE family
GCD22_RS11095	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GCD22_RS11130	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GCD22_RS11160	COG3321	synthase
GCD22_RS11160	COG1028	Short-chain dehydrogenase reductase Sdr
GCD22_RS11160	COG0604	alcohol dehydrogenase
GCD22_RS11255	COG0791	NLP P60 protein
GCD22_RS11265	COG0402	S-adenosylhomocysteine deaminase activity
GCD22_RS11270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GCD22_RS11275	COG0546	phosphoglycolate phosphatase activity
GCD22_RS11295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GCD22_RS11315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GCD22_RS11335	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GCD22_RS11340	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GCD22_RS11345	COG0740	serine-type endopeptidase activity
GCD22_RS11350	COG0544	peptidyl-prolyl cis-trans isomerase activity
GCD22_RS11355	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GCD22_RS11360	COG0284	orotidine-5'-phosphate decarboxylase activity
GCD22_RS11365	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GCD22_RS11370	COG0776	regulation of translation
GCD22_RS11380	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GCD22_RS11385	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GCD22_RS11390	COG0287	Prephenate dehydrogenase
GCD22_RS11395	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GCD22_RS11400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GCD22_RS11410	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GCD22_RS11420	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GCD22_RS11425	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GCD22_RS11440	COG1475	DNA binding
GCD22_RS11445	COG1192	Involved in chromosome partitioning
GCD22_RS11455	COG2948	multi-organism process
GCD22_RS11480	COG1484	DNA-dependent DNA replication
GCD22_RS11485	COG4584	PFAM Integrase catalytic
GCD22_RS11515	COG3451	type IV secretory pathway VirB4
GCD22_RS11540	COG4962	Type ii secretion system protein e
GCD22_RS11565	COG0463	Glycosyl transferase, family 2
GCD22_RS11630	COG0741	lytic transglycosylase activity
GCD22_RS11820	COG0393	Putative heavy-metal-binding
GCD22_RS11880	COG0629	single-stranded DNA binding
GCD22_RS11955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GCD22_RS12050	COG5377	YqaJ viral recombinase family
GCD22_RS12075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GCD22_RS12080	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GCD22_RS12100	COG1487	ribonuclease activity
GCD22_RS12155	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GCD22_RS12170	COG2258	MOSC domain
GCD22_RS12195	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GCD22_RS12205	COG3706	GGDEF domain
GCD22_RS12240	COG5377	YqaJ viral recombinase family
GCD22_RS12335	COG1132	(ABC) transporter
GCD22_RS12340	COG0676	glucose-6-phosphate 1-epimerase activity
GCD22_RS12345	COG2217	Heavy metal translocating P-type atpase
GCD22_RS12350	COG0436	Aminotransferase
GCD22_RS12355	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GCD22_RS12360	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GCD22_RS12365	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GCD22_RS12370	COG0640	Transcriptional regulator
GCD22_RS12375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GCD22_RS12395	COG2826	transposase and inactivated derivatives, IS30 family
GCD22_RS12400	COG0789	Transcriptional regulator
GCD22_RS12465	COG1271	oxidase subunit
GCD22_RS12490	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GCD22_RS12495	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GCD22_RS12515	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GCD22_RS12530	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GCD22_RS12535	COG1140	nitrate reductase beta subunit
GCD22_RS12540	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GCD22_RS12545	COG2181	nitrate reductase activity
GCD22_RS12585	COG0509	glycine decarboxylation via glycine cleavage system
GCD22_RS12590	COG0038	chloride channel
GCD22_RS12595	COG1475	DNA binding
GCD22_RS12600	COG1192	Involved in chromosome partitioning
GCD22_RS12670	COG2226	methyltransferase
GCD22_RS12685	COG3220	belongs to the UPF0276 family
GCD22_RS12695	COG4232	protein-disulfide reductase activity
GCD22_RS12710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GCD22_RS12790	COG5001	Diguanylate cyclase
GCD22_RS12790	COG3300	MHYT domain
GCD22_RS12815	COG0596	Alpha beta hydrolase
GCD22_RS12820	COG0531	amino acid
GCD22_RS12925	COG1538	Outer membrane efflux protein
GCD22_RS12930	COG2814	Major facilitator Superfamily
GCD22_RS12935	COG0038	chloride channel
GCD22_RS12945	COG0583	DNA-binding transcription factor activity
GCD22_RS12950	COG0628	permease
GCD22_RS12955	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GCD22_RS12965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GCD22_RS12980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GCD22_RS12985	COG1758	RNA polymerase activity
GCD22_RS12995	COG1561	YicC-like family, N-terminal region
GCD22_RS13010	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GCD22_RS13040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GCD22_RS13065	COG2193	ferroxidase activity
GCD22_RS13070	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GCD22_RS13075	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GCD22_RS13080	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GCD22_RS13110	COG1850	ribulose-bisphosphate carboxylase activity
GCD22_RS13130	COG0196	riboflavin kinase activity
GCD22_RS13135	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GCD22_RS13140	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GCD22_RS13165	COG4178	(ABC) transporter
GCD22_RS13175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GCD22_RS13185	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GCD22_RS13200	COG4232	protein-disulfide reductase activity
GCD22_RS13210	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GCD22_RS13215	COG0459	protein refolding
GCD22_RS13250	COG1215	transferase activity, transferring glycosyl groups
GCD22_RS13260	COG3447	MASE1 domain protein
GCD22_RS13260	COG5001	Diguanylate cyclase
GCD22_RS13260	COG5002	protein histidine kinase activity
GCD22_RS13325	COG0582	viral genome integration into host DNA
GCD22_RS13415	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GCD22_RS13420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GCD22_RS13425	COG1862	Preprotein translocase
GCD22_RS13430	COG0343	queuine tRNA-ribosyltransferase activity
GCD22_RS13435	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GCD22_RS13440	COG1253	flavin adenine dinucleotide binding
GCD22_RS13455	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GCD22_RS13465	COG0285	dihydrofolate synthase activity
GCD22_RS13470	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GCD22_RS13475	COG0159	tryptophan synthase activity
GCD22_RS13480	COG0133	tryptophan synthase activity
GCD22_RS13485	COG0135	phosphoribosylanthranilate isomerase activity
GCD22_RS13490	COG0101	tRNA pseudouridine synthase activity
GCD22_RS13500	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GCD22_RS13515	COG0746	molybdenum cofactor guanylyltransferase activity
GCD22_RS13520	COG1763	Mo-molybdopterin cofactor biosynthetic process
GCD22_RS13540	COG0500	methyltransferase
GCD22_RS13545	COG0583	DNA-binding transcription factor activity
GCD22_RS13550	COG0477	Major facilitator Superfamily
GCD22_RS13555	COG1538	Outer membrane efflux protein
GCD22_RS13560	COG1566	PFAM secretion protein HlyD family protein
GCD22_RS13585	COG0509	glycine decarboxylation via glycine cleavage system
GCD22_RS13595	COG3189	MarR family transcriptional regulator
GCD22_RS13615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GCD22_RS13665	COG0642	Histidine kinase
GCD22_RS13700	COG2132	Multicopper oxidase
GCD22_RS13730	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GCD22_RS13740	COG0531	amino acid
GCD22_RS13760	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GCD22_RS13765	COG0322	excinuclease ABC activity
GCD22_RS13775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GCD22_RS13780	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GCD22_RS13785	COG0148	phosphopyruvate hydratase activity
GCD22_RS13790	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GCD22_RS13795	COG0504	CTP synthase activity
GCD22_RS13800	COG1064	alcohol dehydrogenase
GCD22_RS13815	COG0640	Transcriptional regulator
GCD22_RS13820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GCD22_RS13845	COG1183	phosphatidylcholine synthase activity
GCD22_RS13850	COG0688	phosphatidylethanolamine metabolic process
GCD22_RS13855	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GCD22_RS13865	COG0028	Belongs to the TPP enzyme family
GCD22_RS13870	COG1193	negative regulation of DNA recombination
GCD22_RS13880	COG0432	Pfam Uncharacterised protein family UPF0047
GCD22_RS13915	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GCD22_RS13920	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GCD22_RS13925	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GCD22_RS13930	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GCD22_RS13935	COG0067	glutamate synthase
GCD22_RS13935	COG0070	glutamate synthase
GCD22_RS13935	COG0069	glutamate synthase activity
GCD22_RS13940	COG0493	'glutamate synthase
GCD22_RS13945	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GCD22_RS13975	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GCD22_RS13985	COG0438	transferase activity, transferring glycosyl groups
GCD22_RS13990	COG1216	Glycosyl transferase, family 2
GCD22_RS14000	COG0438	transferase activity, transferring glycosyl groups
GCD22_RS14045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GCD22_RS14050	COG0438	transferase activity, transferring glycosyl groups
GCD22_RS14065	COG0138	bifunctional purine biosynthesis protein purh
GCD22_RS14070	COG0151	Belongs to the GarS family
GCD22_RS14075	COG0009	L-threonylcarbamoyladenylate synthase
GCD22_RS14080	COG0408	coproporphyrinogen oxidase activity
GCD22_RS14085	COG0167	dihydroorotate dehydrogenase activity
GCD22_RS14090	COG2271	Major facilitator Superfamily
GCD22_RS14110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GCD22_RS14115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GCD22_RS14155	COG0811	peptide transport
GCD22_RS14165	COG0477	Major facilitator Superfamily
GCD22_RS14185	COG0811	peptide transport
GCD22_RS14215	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GCD22_RS14225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GCD22_RS14245	COG0033	Phosphoglucomutase
GCD22_RS14365	COG3093	addiction module antidote protein HigA
GCD22_RS14375	COG4974	Belongs to the 'phage' integrase family
GCD22_RS14380	COG0047	phosphoribosylformylglycinamidine synthase activity
GCD22_RS14380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GCD22_RS14385	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GCD22_RS14390	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GCD22_RS14400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GCD22_RS14405	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GCD22_RS14415	COG1272	protein, Hemolysin III
GCD22_RS14420	COG0860	N-Acetylmuramoyl-L-alanine amidase
GCD22_RS14430	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GCD22_RS14435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCD22_RS14450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GCD22_RS14460	COG0640	Transcriptional regulator
GCD22_RS14470	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GCD22_RS14485	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GCD22_RS14490	COG0084	hydrolase, TatD family'
GCD22_RS14495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GCD22_RS14500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GCD22_RS14535	COG1199	ATP-dependent helicase activity
GCD22_RS14545	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GCD22_RS14550	COG0791	NLP P60 protein
GCD22_RS14585	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GCD22_RS14590	COG0586	Pfam SNARE associated Golgi protein
GCD22_RS14605	COG0583	DNA-binding transcription factor activity
GCD22_RS14695	COG0644	oxidoreductase
GCD22_RS14700	COG0095	Lipoate-protein ligase
GCD22_RS14710	COG0509	glycine decarboxylation via glycine cleavage system
GCD22_RS14720	COG0509	glycine decarboxylation via glycine cleavage system
GCD22_RS14725	COG2048	Heterodisulfide reductase, subunit B
GCD22_RS14755	COG2210	Belongs to the sulfur carrier protein TusA family
GCD22_RS14760	COG0425	Belongs to the sulfur carrier protein TusA family
GCD22_RS14765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCD22_RS14780	COG0437	4 iron, 4 sulfur cluster binding
GCD22_RS14785	COG0243	molybdopterin cofactor binding
GCD22_RS14795	COG0315	cyclic pyranopterin monophosphate synthase activity
GCD22_RS14805	COG3852	Histidine kinase
GCD22_RS14830	COG3258	Cytochrome c
GCD22_RS14835	COG3439	Domain of unknown function DUF302
GCD22_RS14840	COG0737	Belongs to the 5'-nucleotidase family
GCD22_RS14845	COG1077	Cell shape determining protein MreB Mrl
GCD22_RS14850	COG1792	Involved in formation and maintenance of cell shape
GCD22_RS14860	COG0772	Belongs to the SEDS family
GCD22_RS14865	COG1686	Belongs to the peptidase S11 family
GCD22_RS14875	COG0321	lipoyl(octanoyl) transferase activity
GCD22_RS14880	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GCD22_RS14930	COG0751	glycine-tRNA ligase activity
GCD22_RS14935	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GCD22_RS14940	COG0204	Acyl-transferase
GCD22_RS14945	COG0189	ligase activity
GCD22_RS14965	COG2154	pterin-4-alpha-carbinolamine dehydratase
GCD22_RS14970	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GCD22_RS14980	COG3023	N-Acetylmuramoyl-L-alanine amidase
GCD22_RS14995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GCD22_RS15070	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GCD22_RS15075	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GCD22_RS15080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GCD22_RS15090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GCD22_RS15100	COG0058	SHG alpha-glucan phosphorylase activity
GCD22_RS15105	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GCD22_RS15115	COG0793	Belongs to the peptidase S41A family
GCD22_RS15120	COG0693	protein deglycase activity
GCD22_RS15125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GCD22_RS15130	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GCD22_RS15135	COG0542	response to heat
GCD22_RS15140	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GCD22_RS15145	COG0519	Catalyzes the synthesis of GMP from XMP
GCD22_RS15150	COG0450	alkyl hydroperoxide reductase
GCD22_RS15165	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GCD22_RS15170	COG2835	tetraacyldisaccharide 4'-kinase activity
GCD22_RS15175	COG1663	tetraacyldisaccharide 4'-kinase activity
GCD22_RS15190	COG0848	biopolymer transport protein
GCD22_RS15195	COG0811	peptide transport
GCD22_RS15200	COG2333	competence protein COMEC
GCD22_RS15200	COG0658	competence protein
GCD22_RS15245	COG1742	UPF0060 membrane protein
GCD22_RS15255	COG1742	UPF0060 membrane protein
GCD22_RS15260	COG3041	Addiction module toxin RelE StbE family
GCD22_RS15265	COG3077	Addiction module antitoxin, RelB DinJ family
GCD22_RS15270	COG1136	(ABC) transporter
GCD22_RS15280	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GCD22_RS15290	COG1487	ribonuclease activity
GCD22_RS15305	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GCD22_RS15315	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GCD22_RS15325	COG0436	Aminotransferase
GCD22_RS15345	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GCD22_RS15365	COG4221	oxidoreductase activity
GCD22_RS15410	COG2211	Major facilitator Superfamily
GCD22_RS15420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GCD22_RS15440	COG3046	protein related to deoxyribodipyrimidine photolyase
GCD22_RS15460	COG0717	Belongs to the dCTP deaminase family
GCD22_RS15465	COG0489	protein tyrosine kinase activity
GCD22_RS15475	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GCD22_RS15480	COG0484	heat shock protein binding
GCD22_RS15485	COG0443	Heat shock 70 kDa protein
GCD22_RS15490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GCD22_RS15495	COG1420	regulation of RNA biosynthetic process
GCD22_RS15500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GCD22_RS15505	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GCD22_RS15510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GCD22_RS15510	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GCD22_RS15515	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GCD22_RS15520	COG0114	fumarate hydratase activity
GCD22_RS15560	COG0297	glycogen (starch) synthase activity
GCD22_RS15570	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GCD22_RS15580	COG1376	ErfK ybiS ycfS ynhG family protein
GCD22_RS15600	COG3260	NADH ubiquinone oxidoreductase 20
GCD22_RS15605	COG0649	NAD binding
GCD22_RS15610	COG0651	ATP synthesis coupled electron transport
GCD22_RS15645	COG1850	ribulose-bisphosphate carboxylase activity
GCD22_RS15665	COG1872	DUF167
GCD22_RS15670	COG0659	secondary active sulfate transmembrane transporter activity
GCD22_RS15700	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GCD22_RS15705	COG1534	Rna-binding protein
GCD22_RS15710	COG2967	ApaG domain
GCD22_RS15715	COG2226	methyltransferase
GCD22_RS15745	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GCD22_RS15755	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GCD22_RS15770	COG2177	Part of the ABC transporter FtsEX involved in
GCD22_RS15775	COG2884	Cell division ATP-binding protein ftsE
GCD22_RS15780	COG0552	protein localization to endoplasmic reticulum
GCD22_RS15785	COG0742	ribosomal rna small subunit methyltransferase
GCD22_RS15790	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GCD22_RS15795	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GCD22_RS15800	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GCD22_RS15805	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GCD22_RS15810	COG2890	protein-(glutamine-N5) methyltransferase activity
GCD22_RS15815	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GCD22_RS15820	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GCD22_RS15835	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GCD22_RS15845	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GCD22_RS15865	COG0393	Putative heavy-metal-binding
GCD22_RS15920	COG0006	proline dipeptidase activity
GCD22_RS15935	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GCD22_RS15940	COG0305	Participates in initiation and elongation during chromosome replication
GCD22_RS15945	COG0359	binds to the 23S rRNA
GCD22_RS15960	COG0360	Binds together with S18 to 16S ribosomal RNA
GCD22_RS15965	COG1472	Belongs to the glycosyl hydrolase 3 family
GCD22_RS15970	COG0531	amino acid
GCD22_RS15980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GCD22_RS16010	COG0363	glucosamine-6-phosphate deaminase activity
GCD22_RS16025	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GCD22_RS16030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GCD22_RS16040	COG1449	Belongs to the glycosyl hydrolase 57 family
GCD22_RS16045	COG1940	carbohydrate kinase activity
GCD22_RS16060	COG2733	membrane
GCD22_RS16080	COG0629	single-stranded DNA binding
GCD22_RS16095	COG3118	belongs to the thioredoxin family
GCD22_RS16100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GCD22_RS16120	COG0335	large ribosomal subunit rRNA binding
GCD22_RS16125	COG0336	Belongs to the RNA methyltransferase TrmD family
GCD22_RS16130	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GCD22_RS16135	COG0228	four-way junction DNA binding
GCD22_RS16140	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GCD22_RS16165	COG2885	chlorophyll binding
GCD22_RS16165	COG3047	cAMP biosynthetic process
GCD22_RS16235	COG2944	sequence-specific DNA binding
GCD22_RS16245	COG1573	uracil-dna glycosylase
GCD22_RS16255	COG0488	(ABC) transporter
GCD22_RS16285	COG0142	geranyltranstransferase activity
GCD22_RS16300	COG3852	Histidine kinase
GCD22_RS16310	COG2308	Evidence 4 Homologs of previously reported genes of
GCD22_RS16330	COG2766	serine protein kinase
GCD22_RS16335	COG0004	ammonium transporteR
GCD22_RS16340	COG2718	Belongs to the UPF0229 family
GCD22_RS16345	COG2719	SpoVR family
GCD22_RS16355	COG0347	Belongs to the P(II) protein family
GCD22_RS16360	COG0004	ammonium transporteR
GCD22_RS16400	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GCD22_RS16410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GCD22_RS16415	COG0768	penicillin binding
GCD22_RS16420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GCD22_RS16425	COG1686	Belongs to the peptidase S11 family
GCD22_RS16430	COG0823	Involved in the tonB-independent uptake of proteins
GCD22_RS16460	COG0583	DNA-binding transcription factor activity
GCD22_RS16470	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GCD22_RS16475	COG1686	Belongs to the peptidase S11 family
GCD22_RS16480	COG0166	Belongs to the GPI family
GCD22_RS16485	COG1271	oxidase subunit
GCD22_RS16490	COG1294	oxidase, subunit
GCD22_RS16515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GCD22_RS16535	COG0651	ATP synthesis coupled electron transport
GCD22_RS16545	COG3260	NADH ubiquinone oxidoreductase 20
GCD22_RS16550	COG0651	ATP synthesis coupled electron transport
GCD22_RS16555	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GCD22_RS16570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GCD22_RS16585	COG0583	DNA-binding transcription factor activity
GCD22_RS16610	COG3220	belongs to the UPF0276 family
GCD22_RS16620	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GCD22_RS16625	COG1074	ATP-dependent DNA helicase activity
GCD22_RS16630	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GCD22_RS16645	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GCD22_RS16655	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GCD22_RS16660	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GCD22_RS16705	COG0792	nuclease activity
GCD22_RS16710	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GCD22_RS16715	COG0277	FAD linked oxidase domain protein
GCD22_RS16725	COG0859	PFAM glycosyl transferase family 9
GCD22_RS16740	COG0583	DNA-binding transcription factor activity
GCD22_RS16750	COG1393	Belongs to the ArsC family
GCD22_RS16770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GCD22_RS16775	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GCD22_RS16780	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GCD22_RS16790	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GCD22_RS16795	COG2833	Protein of unknown function (DUF455)
GCD22_RS16800	COG1271	oxidase subunit
GCD22_RS16805	COG1294	oxidase, subunit
GCD22_RS16825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GCD22_RS16850	COG1914	H( )-stimulated, divalent metal cation uptake system
GCD22_RS16855	COG3842	ATPase activity
GCD22_RS16865	COG1178	ABC-type Fe3 transport system permease component
GCD22_RS16885	COG3145	DNA-N1-methyladenine dioxygenase activity
GCD22_RS16895	COG0583	DNA-binding transcription factor activity
GCD22_RS16920	COG2259	Doxx family
GCD22_RS16925	COG3384	dioxygenase
GCD22_RS16935	COG0583	DNA-binding transcription factor activity
GCD22_RS16945	COG0655	NAD(P)H dehydrogenase (quinone) activity
GCD22_RS16980	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GCD22_RS17095	COG0019	diaminopimelate decarboxylase activity
GCD22_RS17105	COG0165	Argininosuccinate lyase
GCD22_RS17135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GCD22_RS17140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GCD22_RS17150	COG1970	mechanosensitive ion channel activity
GCD22_RS17155	COG1322	Protein conserved in bacteria
GCD22_RS17160	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GCD22_RS17165	COG2326	polyphosphate kinase activity
GCD22_RS17170	COG2814	Major facilitator Superfamily
GCD22_RS17175	COG0598	Magnesium transport protein CorA
GCD22_RS17180	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GCD22_RS17190	COG1494	fructose-1,6-bisphosphatase
GCD22_RS17195	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GCD22_RS17200	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GCD22_RS17205	COG0126	phosphoglycerate kinase activity
GCD22_RS17210	COG0469	pyruvate kinase activity
GCD22_RS17215	COG0191	fructose-bisphosphate aldolase activity
GCD22_RS17220	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GCD22_RS17225	COG0546	phosphoglycolate phosphatase activity
GCD22_RS17250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GCD22_RS17255	COG0134	indole-3-glycerol-phosphate synthase activity
GCD22_RS17265	COG1959	2 iron, 2 sulfur cluster binding
GCD22_RS17270	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
GCD22_RS17280	COG2945	thiolester hydrolase activity
GCD22_RS17285	COG1131	(ABC) transporter
GCD22_RS17325	COG0776	regulation of translation
GCD22_RS17340	COG0393	Putative heavy-metal-binding
GCD22_RS17355	COG1216	Glycosyl transferase, family 2
GCD22_RS17355	COG0438	transferase activity, transferring glycosyl groups
GCD22_RS17435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GCD22_RS17440	COG1278	Cold shock
GCD22_RS17445	COG2084	Dehydrogenase
GCD22_RS17450	COG0243	molybdopterin cofactor binding
GCD22_RS17460	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GCD22_RS17465	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GCD22_RS17475	COG2271	Major facilitator Superfamily
GCD22_RS17485	COG0113	porphobilinogen synthase activity
GCD22_RS17495	COG0181	hydroxymethylbilane synthase activity
GCD22_RS17500	COG2885	chlorophyll binding
GCD22_RS17510	COG0602	queuosine metabolic process
GCD22_RS17520	COG0823	Involved in the tonB-independent uptake of proteins
GCD22_RS17540	COG0824	Thioesterase
GCD22_RS17545	COG2255	four-way junction helicase activity
GCD22_RS17550	COG0632	four-way junction helicase activity
GCD22_RS17555	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GCD22_RS17560	COG0217	transcriptional regulatory protein
GCD22_RS17570	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GCD22_RS17575	COG0494	nUDIX hydrolase
GCD22_RS17580	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GCD22_RS17590	COG2095	MarC family integral membrane protein
GCD22_RS17620	COG2814	Major facilitator Superfamily
GCD22_RS17625	COG3842	ATPase activity
GCD22_RS17630	COG0395	ABC-type sugar transport system, permease component
GCD22_RS17650	COG1172	Belongs to the binding-protein-dependent transport system permease family
GCD22_RS17665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GCD22_RS17695	COG2376	Dihydroxyacetone kinase
GCD22_RS17700	COG1461	Dihydroxyacetone kinase
GCD22_RS17725	COG0488	(ABC) transporter
GCD22_RS17730	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GCD22_RS17740	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GCD22_RS17745	COG0732	type I restriction modification DNA specificity domain
GCD22_RS17750	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GCD22_RS17755	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GCD22_RS17760	COG0594	ribonuclease P activity
GCD22_RS17765	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GCD22_RS17770	COG0706	membrane insertase activity
GCD22_RS17775	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GCD22_RS17785	COG1560	Kdo2-lipid A biosynthetic process
GCD22_RS17790	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GCD22_RS17800	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GCD22_RS17820	COG1530	ribonuclease E activity
GCD22_RS17825	COG1555	photosystem II stabilization
GCD22_RS17830	COG0537	adenosine 5'-monophosphoramidase activity
GCD22_RS17835	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GCD22_RS17840	COG0352	thiamine-phosphate diphosphorylase activity
GCD22_RS17845	COG0352	thiamine-phosphate diphosphorylase activity
GCD22_RS17845	COG0351	phosphomethylpyrimidine kinase
GCD22_RS17855	COG4221	oxidoreductase activity