locus-tag	class	description
ACPOL_RS00025	COG1069	ribulokinase activity
ACPOL_RS00055	COG1174	glycine betaine transport
ACPOL_RS00080	COG0126	phosphoglycerate kinase activity
ACPOL_RS00105	COG0149	triose-phosphate isomerase activity
ACPOL_RS00115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACPOL_RS00115	COG0519	Catalyzes the synthesis of GMP from XMP
ACPOL_RS00125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ACPOL_RS00130	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACPOL_RS00165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACPOL_RS00170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACPOL_RS00180	COG0697	spore germination
ACPOL_RS00200	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACPOL_RS00200	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACPOL_RS00205	COG1917	Cupin 2, conserved barrel domain protein
ACPOL_RS00205	COG4977	sequence-specific DNA binding
ACPOL_RS00240	COG1040	competence protein
ACPOL_RS00245	COG2132	Multicopper oxidase
ACPOL_RS00255	COG0783	Belongs to the Dps family
ACPOL_RS00275	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACPOL_RS00285	COG1030	water channel activity
ACPOL_RS00290	COG0330	HflC and HflK could
ACPOL_RS00305	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACPOL_RS00310	COG1619	proteins homologs of microcin C7 resistance protein MccF
ACPOL_RS00315	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ACPOL_RS00335	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ACPOL_RS00355	COG4206	TonB-dependent receptor
ACPOL_RS00360	COG0321	lipoyl(octanoyl) transferase activity
ACPOL_RS00360	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ACPOL_RS00365	COG0196	riboflavin kinase activity
ACPOL_RS00375	COG0653	protein targeting
ACPOL_RS00390	COG3609	addiction module antidote protein, CC2985 family
ACPOL_RS00400	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACPOL_RS00415	COG2226	methyltransferase
ACPOL_RS00430	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACPOL_RS00435	COG0463	Glycosyl transferase, family 2
ACPOL_RS00440	COG0676	glucose-6-phosphate 1-epimerase activity
ACPOL_RS00445	COG0375	protein maturation
ACPOL_RS00450	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ACPOL_RS00455	COG0298	carbon dioxide binding
ACPOL_RS00460	COG0409	Hydrogenase expression formation protein
ACPOL_RS00465	COG0309	Hydrogenase expression formation protein (HypE)
ACPOL_RS00480	COG1960	acyl-CoA dehydrogenase activity
ACPOL_RS00525	COG0626	cystathionine gamma-synthase activity
ACPOL_RS00530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACPOL_RS00560	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ACPOL_RS00565	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ACPOL_RS00575	COG1136	(ABC) transporter
ACPOL_RS00575	COG0577	efflux transmembrane transporter activity
ACPOL_RS00580	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACPOL_RS00600	COG1776	CheC inhibitor of MCP methylation
ACPOL_RS00600	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACPOL_RS00610	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACPOL_RS00615	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACPOL_RS00675	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACPOL_RS00690	COG1558	bacterial-type flagellum-dependent cell motility
ACPOL_RS00695	COG1815	bacterial-type flagellum-dependent cell motility
ACPOL_RS00700	COG3604	Transcriptional regulator
ACPOL_RS00710	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACPOL_RS00715	COG3118	belongs to the thioredoxin family
ACPOL_RS00720	COG0083	homoserine kinase activity
ACPOL_RS00725	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACPOL_RS00730	COG1136	(ABC) transporter
ACPOL_RS00730	COG0577	efflux transmembrane transporter activity
ACPOL_RS00735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ACPOL_RS00755	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACPOL_RS00805	COG0148	phosphopyruvate hydratase activity
ACPOL_RS00815	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ACPOL_RS00845	COG0539	negative regulation of cytoplasmic translation
ACPOL_RS00850	COG4297	protein containing double-stranded beta helix domain
ACPOL_RS00870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACPOL_RS00875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACPOL_RS00885	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ACPOL_RS00895	COG0303	'Molybdopterin
ACPOL_RS00905	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
ACPOL_RS00910	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACPOL_RS00940	COG1201	RNA secondary structure unwinding
ACPOL_RS00950	COG0596	Alpha beta hydrolase
ACPOL_RS00955	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ACPOL_RS00955	COG3608	succinylglutamate desuccinylase aspartoacylase
ACPOL_RS00960	COG0746	molybdenum cofactor guanylyltransferase activity
ACPOL_RS00965	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACPOL_RS00970	COG0315	cyclic pyranopterin monophosphate synthase activity
ACPOL_RS00975	COG0314	molybdopterin synthase activity
ACPOL_RS00980	COG0725	ABC transporter, periplasmic molybdate-binding protein
ACPOL_RS00995	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACPOL_RS01000	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ACPOL_RS01010	COG0746	molybdenum cofactor guanylyltransferase activity
ACPOL_RS01025	COG3383	formate dehydrogenase (NAD+) activity
ACPOL_RS01045	COG0546	phosphoglycolate phosphatase activity
ACPOL_RS01050	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACPOL_RS01055	COG0456	acetyltransferase
ACPOL_RS01070	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACPOL_RS01080	COG0347	Belongs to the P(II) protein family
ACPOL_RS01085	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ACPOL_RS01115	COG1268	BioY protein
ACPOL_RS01145	COG0631	protein serine/threonine phosphatase activity
ACPOL_RS01155	COG2199	diguanylate cyclase activity
ACPOL_RS01160	COG1201	RNA secondary structure unwinding
ACPOL_RS01180	COG0582	viral genome integration into host DNA
ACPOL_RS01205	COG0305	Participates in initiation and elongation during chromosome replication
ACPOL_RS01230	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS01240	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS01255	COG0662	Cupin 2, conserved barrel domain protein
ACPOL_RS01255	COG2207	Transcriptional regulator
ACPOL_RS01265	COG1309	transcriptional regulator
ACPOL_RS01310	COG1595	DNA-templated transcription, initiation
ACPOL_RS01320	COG0477	Major facilitator Superfamily
ACPOL_RS01340	COG2267	carboxylic ester hydrolase activity
ACPOL_RS01345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACPOL_RS01355	COG0492	ferredoxin-NADP+ reductase activity
ACPOL_RS01375	COG0745	RESPONSE REGULATOR receiver
ACPOL_RS01375	COG2205	protein histidine kinase activity
ACPOL_RS01375	COG3292	Two component regulator propeller
ACPOL_RS01385	COG2197	response regulator
ACPOL_RS01450	COG3344	reverse transcriptase
ACPOL_RS01510	COG0572	uridine kinase
ACPOL_RS01595	COG1472	Belongs to the glycosyl hydrolase 3 family
ACPOL_RS01600	COG2382	esterase
ACPOL_RS01600	COG3693	PFAM glycoside hydrolase, family 10
ACPOL_RS01620	COG2208	phosphoserine phosphatase activity
ACPOL_RS01625	COG1295	ribonuclease BN
ACPOL_RS01630	COG1278	Cold shock
ACPOL_RS01635	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ACPOL_RS01670	COG0142	geranyltranstransferase activity
ACPOL_RS01675	COG2151	metal-sulfur cluster biosynthetic enzyme
ACPOL_RS01680	COG1278	Cold shock
ACPOL_RS01695	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ACPOL_RS01720	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ACPOL_RS01720	COG1796	DNA polymerase
ACPOL_RS01740	COG0281	malic enzyme
ACPOL_RS01745	COG0114	fumarate hydratase activity
ACPOL_RS01800	COG1418	mRNA catabolic process
ACPOL_RS01835	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ACPOL_RS01840	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ACPOL_RS01850	COG3345	alpha-galactosidase
ACPOL_RS01865	COG2271	Major facilitator Superfamily
ACPOL_RS01870	COG0363	glucosamine-6-phosphate deaminase activity
ACPOL_RS01875	COG2222	sugar isomerase
ACPOL_RS01880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACPOL_RS01905	COG0640	Transcriptional regulator
ACPOL_RS01940	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
ACPOL_RS01945	COG1733	regulation of RNA biosynthetic process
ACPOL_RS01975	COG0824	Thioesterase
ACPOL_RS01980	COG0750	zinc metalloprotease
ACPOL_RS01985	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ACPOL_RS02000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACPOL_RS02020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACPOL_RS02040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACPOL_RS02050	COG0667	Aldo Keto reductase
ACPOL_RS02080	COG2201	protein-glutamate methylesterase activity
ACPOL_RS02085	COG1846	Transcriptional regulator
ACPOL_RS02090	COG2353	YceI-like domain
ACPOL_RS02095	COG2814	Major facilitator Superfamily
ACPOL_RS02135	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACPOL_RS02140	COG1872	DUF167
ACPOL_RS02145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ACPOL_RS02175	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS02190	COG1899	peptidyl-lysine modification to peptidyl-hypusine
ACPOL_RS02195	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACPOL_RS02200	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ACPOL_RS02210	COG0154	amidase activity
ACPOL_RS02300	COG4962	Type ii secretion system protein e
ACPOL_RS02340	COG1196	nuclear chromosome segregation
ACPOL_RS02345	COG4191	Histidine kinase
ACPOL_RS02390	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS02400	COG5001	Diguanylate cyclase
ACPOL_RS02405	COG3548	integral membrane protein
ACPOL_RS02420	COG3145	DNA-N1-methyladenine dioxygenase activity
ACPOL_RS02430	COG2169	Transcriptional regulator
ACPOL_RS02430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACPOL_RS02435	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ACPOL_RS02515	COG4221	oxidoreductase activity
ACPOL_RS02550	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ACPOL_RS02555	COG1012	belongs to the aldehyde dehydrogenase family
ACPOL_RS02560	COG0583	DNA-binding transcription factor activity
ACPOL_RS02635	COG2226	methyltransferase
ACPOL_RS02645	COG2311	Membrane
ACPOL_RS02650	COG0583	DNA-binding transcription factor activity
ACPOL_RS02670	COG4221	oxidoreductase activity
ACPOL_RS02675	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS02700	COG2207	Transcriptional regulator
ACPOL_RS02750	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ACPOL_RS02755	COG0667	Aldo Keto reductase
ACPOL_RS02760	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS02770	COG0596	Alpha beta hydrolase
ACPOL_RS02780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ACPOL_RS02805	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS02815	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS02825	COG1253	flavin adenine dinucleotide binding
ACPOL_RS02865	COG2311	Membrane
ACPOL_RS02870	COG0583	DNA-binding transcription factor activity
ACPOL_RS02895	COG0582	viral genome integration into host DNA
ACPOL_RS02905	COG0583	DNA-binding transcription factor activity
ACPOL_RS02940	COG3590	peptidase
ACPOL_RS02965	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS02970	COG0583	DNA-binding transcription factor activity
ACPOL_RS02980	COG2197	response regulator
ACPOL_RS02995	COG1064	alcohol dehydrogenase
ACPOL_RS03000	COG1902	pentaerythritol trinitrate reductase activity
ACPOL_RS03005	COG1063	alcohol dehydrogenase
ACPOL_RS03010	COG1902	pentaerythritol trinitrate reductase activity
ACPOL_RS03025	COG3850	Histidine kinase
ACPOL_RS03060	COG1063	alcohol dehydrogenase
ACPOL_RS03065	COG1073	alpha beta
ACPOL_RS03150	COG1733	regulation of RNA biosynthetic process
ACPOL_RS03165	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ACPOL_RS03170	COG0477	Major facilitator Superfamily
ACPOL_RS03195	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS03200	COG4977	sequence-specific DNA binding
ACPOL_RS03210	COG2197	response regulator
ACPOL_RS03255	COG1902	pentaerythritol trinitrate reductase activity
ACPOL_RS03275	COG0596	Alpha beta hydrolase
ACPOL_RS03285	COG2311	Membrane
ACPOL_RS03295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACPOL_RS03310	COG0114	fumarate hydratase activity
ACPOL_RS03350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACPOL_RS03370	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS03375	COG4977	sequence-specific DNA binding
ACPOL_RS03390	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS03410	COG4221	oxidoreductase activity
ACPOL_RS03415	COG1309	transcriptional regulator
ACPOL_RS03420	COG1136	(ABC) transporter
ACPOL_RS03420	COG0577	efflux transmembrane transporter activity
ACPOL_RS03425	COG1695	Transcriptional regulator
ACPOL_RS03505	COG0438	transferase activity, transferring glycosyl groups
ACPOL_RS03535	COG0297	glycogen (starch) synthase activity
ACPOL_RS03625	COG0745	RESPONSE REGULATOR receiver
ACPOL_RS03625	COG3292	Two component regulator propeller
ACPOL_RS03625	COG2205	protein histidine kinase activity
ACPOL_RS03630	COG4585	Histidine kinase
ACPOL_RS03665	COG3850	Histidine kinase
ACPOL_RS03670	COG2197	response regulator
ACPOL_RS03680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACPOL_RS03685	COG1538	Outer membrane efflux protein
ACPOL_RS03710	COG0798	PFAM Bile acid sodium symporter
ACPOL_RS03715	COG0640	Transcriptional regulator
ACPOL_RS03720	COG0346	lactoylglutathione lyase activity
ACPOL_RS03725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACPOL_RS03740	COG0006	proline dipeptidase activity
ACPOL_RS03755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACPOL_RS03780	COG1136	(ABC) transporter
ACPOL_RS03780	COG0577	efflux transmembrane transporter activity
ACPOL_RS03820	COG5002	protein histidine kinase activity
ACPOL_RS03880	COG3237	CsbD-like
ACPOL_RS03900	COG0629	single-stranded DNA binding
ACPOL_RS03950	COG2267	carboxylic ester hydrolase activity
ACPOL_RS03965	COG0405	Gamma-glutamyltransferase
ACPOL_RS04030	COG2197	response regulator
ACPOL_RS04035	COG4585	Histidine kinase
ACPOL_RS04065	COG2160	L-arabinose isomerase activity
ACPOL_RS04075	COG1501	Belongs to the glycosyl hydrolase 31 family
ACPOL_RS04085	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACPOL_RS04095	COG2080	2 iron, 2 sulfur cluster binding
ACPOL_RS04100	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS04110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACPOL_RS04135	COG0714	Associated with various cellular activities
ACPOL_RS04160	COG2132	Multicopper oxidase
ACPOL_RS04255	COG2801	Transposase and inactivated derivatives
ACPOL_RS04260	COG3547	Transposase (IS116 IS110 IS902 family)
ACPOL_RS04335	COG3293	Transposase
ACPOL_RS04430	COG4974	Belongs to the 'phage' integrase family
ACPOL_RS04445	COG1136	(ABC) transporter
ACPOL_RS04460	COG0450	alkyl hydroperoxide reductase
ACPOL_RS04475	COG3876	Protein conserved in bacteria
ACPOL_RS04485	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ACPOL_RS04505	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ACPOL_RS04520	COG2897	thiosulfate sulfurtransferase activity
ACPOL_RS04530	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS04570	COG2197	response regulator
ACPOL_RS04580	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACPOL_RS04595	COG1819	glycosyl
ACPOL_RS04600	COG1609	Transcriptional regulator
ACPOL_RS04605	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ACPOL_RS04610	COG1104	cysteine desulfurase activity
ACPOL_RS04615	COG0482	sulfurtransferase activity
ACPOL_RS04670	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ACPOL_RS04695	COG0443	Heat shock 70 kDa protein
ACPOL_RS04700	COG0484	heat shock protein binding
ACPOL_RS04705	COG0789	Transcriptional regulator
ACPOL_RS04720	COG0577	efflux transmembrane transporter activity
ACPOL_RS04720	COG1136	(ABC) transporter
ACPOL_RS04745	COG0217	transcriptional regulatory protein
ACPOL_RS04755	COG0628	permease
ACPOL_RS04765	COG0659	secondary active sulfate transmembrane transporter activity
ACPOL_RS04770	COG0047	phosphoribosylformylglycinamidine synthase activity
ACPOL_RS04775	COG4464	protein tyrosine phosphatase activity
ACPOL_RS04780	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS04785	COG2197	response regulator
ACPOL_RS04790	COG0673	inositol 2-dehydrogenase activity
ACPOL_RS04810	COG0546	phosphoglycolate phosphatase activity
ACPOL_RS04840	COG1706	bacterial-type flagellum-dependent cell motility
ACPOL_RS04845	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ACPOL_RS04855	COG4786	Flagellar basal body rod
ACPOL_RS04860	COG4786	Flagellar basal body rod
ACPOL_RS04865	COG0436	Aminotransferase
ACPOL_RS04870	COG0475	glutathione-regulated potassium exporter activity
ACPOL_RS04875	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACPOL_RS04880	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACPOL_RS04890	COG3361	conserved protein (COG2071)
ACPOL_RS04905	COG1295	ribonuclease BN
ACPOL_RS04915	COG1476	TRANSCRIPTIONal
ACPOL_RS04925	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACPOL_RS04935	COG0512	Glutamine amidotransferase of anthranilate synthase
ACPOL_RS04945	COG0583	DNA-binding transcription factor activity
ACPOL_RS04955	COG2855	membrane
ACPOL_RS04965	COG0730	response to heat
ACPOL_RS04975	COG0515	serine threonine protein kinase
ACPOL_RS04975	COG2815	serine threonine protein kinase
ACPOL_RS04980	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS05015	COG0642	Histidine kinase
ACPOL_RS05030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACPOL_RS05035	COG0473	3-isopropylmalate dehydrogenase activity
ACPOL_RS05040	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ACPOL_RS05045	COG0066	3-isopropylmalate dehydratase activity
ACPOL_RS05050	COG0129	dihydroxy-acid dehydratase activity
ACPOL_RS05055	COG0028	Belongs to the TPP enzyme family
ACPOL_RS05060	COG0440	acetolactate synthase activity
ACPOL_RS05065	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ACPOL_RS05125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACPOL_RS05140	COG1595	DNA-templated transcription, initiation
ACPOL_RS05155	COG1278	Cold shock
ACPOL_RS05175	COG0006	proline dipeptidase activity
ACPOL_RS05180	COG1070	Carbohydrate kinase
ACPOL_RS05200	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACPOL_RS05205	COG0842	Transport permease protein
ACPOL_RS05225	COG4221	oxidoreductase activity
ACPOL_RS05230	COG2084	Dehydrogenase
ACPOL_RS05240	COG2197	response regulator
ACPOL_RS05250	COG1674	ftsk spoiiie
ACPOL_RS05255	COG1968	undecaprenyl-diphosphatase activity
ACPOL_RS05265	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ACPOL_RS05270	COG2171	N-acyltransferase activity
ACPOL_RS05275	COG0456	acetyltransferase
ACPOL_RS05280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACPOL_RS05290	COG0527	aspartate kinase activity
ACPOL_RS05305	COG0473	3-isopropylmalate dehydrogenase activity
ACPOL_RS05310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACPOL_RS05330	COG0741	lytic transglycosylase activity
ACPOL_RS05340	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ACPOL_RS05355	COG3132	Protein of unknown function, DUF480
ACPOL_RS05400	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ACPOL_RS05405	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACPOL_RS05410	COG1832	CoA-binding protein
ACPOL_RS05420	COG1193	negative regulation of DNA recombination
ACPOL_RS05440	COG0577	efflux transmembrane transporter activity
ACPOL_RS05440	COG1136	(ABC) transporter
ACPOL_RS05465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACPOL_RS05470	COG0494	nUDIX hydrolase
ACPOL_RS05485	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ACPOL_RS05500	COG3387	PFAM Glycoside hydrolase 15-related
ACPOL_RS05515	COG2197	response regulator
ACPOL_RS05525	COG3394	polysaccharide catabolic process
ACPOL_RS05530	COG0438	transferase activity, transferring glycosyl groups
ACPOL_RS05535	COG3275	phosphorelay sensor kinase activity
ACPOL_RS05550	COG0494	nUDIX hydrolase
ACPOL_RS05560	COG4974	Belongs to the 'phage' integrase family
ACPOL_RS05565	COG4974	Belongs to the 'phage' integrase family
ACPOL_RS05605	COG0793	Belongs to the peptidase S41A family
ACPOL_RS05605	COG3409	Peptidoglycan-binding domain 1 protein
ACPOL_RS05635	COG1874	Beta-galactosidase
ACPOL_RS05645	COG0018	arginyl-trna synthetase
ACPOL_RS05655	COG0084	hydrolase, TatD family'
ACPOL_RS05660	COG1666	GTP binding
ACPOL_RS05665	COG0142	geranyltranstransferase activity
ACPOL_RS05670	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACPOL_RS05670	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACPOL_RS05685	COG3459	Glycosyltransferase 36 associated
ACPOL_RS05685	COG3459	Glycosyltransferase 36 associated
ACPOL_RS05690	COG2208	phosphoserine phosphatase activity
ACPOL_RS05735	COG0489	protein tyrosine kinase activity
ACPOL_RS05765	COG1063	alcohol dehydrogenase
ACPOL_RS05775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACPOL_RS05790	COG1657	PFAM Prenyltransferase squalene oxidase
ACPOL_RS05795	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACPOL_RS05805	COG0497	DNA recombination
ACPOL_RS05820	COG3119	arylsulfatase activity
ACPOL_RS05825	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ACPOL_RS05830	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ACPOL_RS05845	COG1793	dna ligase
ACPOL_RS05850	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACPOL_RS05855	COG2890	protein-(glutamine-N5) methyltransferase activity
ACPOL_RS05860	COG0542	response to heat
ACPOL_RS05870	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ACPOL_RS05890	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACPOL_RS05895	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ACPOL_RS05915	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACPOL_RS05925	COG0495	leucyl-tRNA aminoacylation
ACPOL_RS05950	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ACPOL_RS05975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACPOL_RS05990	COG2267	carboxylic ester hydrolase activity
ACPOL_RS05995	COG3447	MASE1 domain protein
ACPOL_RS05995	COG5002	protein histidine kinase activity
ACPOL_RS05995	COG5001	Diguanylate cyclase
ACPOL_RS06000	COG4251	negative regulation of phosphorylation
ACPOL_RS06005	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ACPOL_RS06010	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ACPOL_RS06015	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACPOL_RS06030	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ACPOL_RS06040	COG0124	histidyl-tRNA synthetase
ACPOL_RS06045	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACPOL_RS06055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACPOL_RS06075	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS06080	COG1196	nuclear chromosome segregation
ACPOL_RS06110	COG2223	nitrite transmembrane transporter activity
ACPOL_RS06120	COG3547	Transposase (IS116 IS110 IS902 family)
ACPOL_RS06125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACPOL_RS06125	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ACPOL_RS06130	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACPOL_RS06130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACPOL_RS06135	COG1127	ABC transporter
ACPOL_RS06165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACPOL_RS06175	COG0802	atpase or kinase
ACPOL_RS06180	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACPOL_RS06180	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ACPOL_RS06185	COG0768	penicillin binding
ACPOL_RS06190	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACPOL_RS06200	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ACPOL_RS06205	COG1446	asparaginase
ACPOL_RS06210	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ACPOL_RS06215	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ACPOL_RS06220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACPOL_RS06230	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ACPOL_RS06300	COG1595	DNA-templated transcription, initiation
ACPOL_RS06305	COG1309	transcriptional regulator
ACPOL_RS06325	COG2124	cytochrome p450
ACPOL_RS06335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACPOL_RS06355	COG1819	glycosyl
ACPOL_RS06375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACPOL_RS06380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACPOL_RS06395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACPOL_RS06400	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS06430	COG0300	oxidoreductase activity
ACPOL_RS06435	COG1733	regulation of RNA biosynthetic process
ACPOL_RS06465	COG1695	Transcriptional regulator
ACPOL_RS06485	COG0009	L-threonylcarbamoyladenylate synthase
ACPOL_RS06490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACPOL_RS06500	COG0531	amino acid
ACPOL_RS06560	COG0745	RESPONSE REGULATOR receiver
ACPOL_RS06575	COG0571	ribonuclease III activity
ACPOL_RS06580	COG0681	Belongs to the peptidase S26 family
ACPOL_RS06600	COG1846	Transcriptional regulator
ACPOL_RS06610	COG0251	oxidation-reduction process
ACPOL_RS06620	COG1609	Transcriptional regulator
ACPOL_RS06625	COG2255	four-way junction helicase activity
ACPOL_RS06635	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ACPOL_RS06650	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ACPOL_RS06660	COG0742	ribosomal rna small subunit methyltransferase
ACPOL_RS06670	COG1764	response to oxidative stress
ACPOL_RS06675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACPOL_RS06685	COG0739	heme binding
ACPOL_RS06735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACPOL_RS06740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACPOL_RS06760	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACPOL_RS06785	COG1064	alcohol dehydrogenase
ACPOL_RS06795	COG0825	malonyl-CoA metabolic process
ACPOL_RS06805	COG1012	belongs to the aldehyde dehydrogenase family
ACPOL_RS06820	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACPOL_RS06825	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
ACPOL_RS06830	COG0167	dihydroorotate dehydrogenase activity
ACPOL_RS06840	COG3684	Belongs to the aldolase LacD family
ACPOL_RS06850	COG2205	protein histidine kinase activity
ACPOL_RS06855	COG2204	response regulator
ACPOL_RS06875	COG3685	Protein conserved in bacteria
ACPOL_RS06880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACPOL_RS06885	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ACPOL_RS06890	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ACPOL_RS06900	COG1058	Belongs to the CinA family
ACPOL_RS06900	COG1546	Belongs to the CinA family
ACPOL_RS06905	COG1501	Belongs to the glycosyl hydrolase 31 family
ACPOL_RS06910	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ACPOL_RS06915	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACPOL_RS06920	COG0768	penicillin binding
ACPOL_RS06930	COG0275	rRNA processing
ACPOL_RS06935	COG2001	Belongs to the MraZ family
ACPOL_RS06945	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ACPOL_RS06955	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACPOL_RS06985	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ACPOL_RS06990	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ACPOL_RS07015	COG3250	beta-galactosidase activity
ACPOL_RS07030	COG0681	Belongs to the peptidase S26 family
ACPOL_RS07045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACPOL_RS07065	COG3279	Response regulator of the LytR AlgR family
ACPOL_RS07080	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ACPOL_RS07095	COG0644	oxidoreductase
ACPOL_RS07095	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
ACPOL_RS07110	COG4555	ABC transporter
ACPOL_RS07135	COG1595	DNA-templated transcription, initiation
ACPOL_RS07145	COG1950	PFAM Membrane protein of
ACPOL_RS07155	COG1285	pathogenesis
ACPOL_RS07175	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ACPOL_RS07180	COG2226	methyltransferase
ACPOL_RS07190	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS07195	COG1914	H( )-stimulated, divalent metal cation uptake system
ACPOL_RS07220	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACPOL_RS07225	COG0154	amidase activity
ACPOL_RS07250	COG4999	Histidine kinase
ACPOL_RS07250	COG3850	Histidine kinase
ACPOL_RS07250	COG3437	response regulator, receiver
ACPOL_RS07250	COG2205	protein histidine kinase activity
ACPOL_RS07255	COG4993	Dehydrogenase
ACPOL_RS07280	COG0531	amino acid
ACPOL_RS07285	COG2271	Major facilitator Superfamily
ACPOL_RS07295	COG4122	O-methyltransferase activity
ACPOL_RS07305	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
ACPOL_RS07315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACPOL_RS07320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACPOL_RS07325	COG2308	Evidence 4 Homologs of previously reported genes of
ACPOL_RS07335	COG1305	Transglutaminase-like
ACPOL_RS07340	COG0300	oxidoreductase activity
ACPOL_RS07350	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ACPOL_RS07350	COG0546	phosphoglycolate phosphatase activity
ACPOL_RS07355	COG0433	COG0433 Predicted ATPase
ACPOL_RS07375	COG2814	Major facilitator Superfamily
ACPOL_RS07405	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACPOL_RS07410	COG0726	polysaccharide deacetylase
ACPOL_RS07415	COG1428	Deoxynucleoside kinase
ACPOL_RS07420	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACPOL_RS07425	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ACPOL_RS07430	COG2094	Belongs to the DNA glycosylase MPG family
ACPOL_RS07435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACPOL_RS07450	COG0151	Belongs to the GarS family
ACPOL_RS07465	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACPOL_RS07485	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACPOL_RS07505	COG4956	integral membrane protein (PIN domain superfamily)
ACPOL_RS07515	COG4191	Histidine kinase
ACPOL_RS07540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACPOL_RS07580	COG0437	4 iron, 4 sulfur cluster binding
ACPOL_RS07590	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ACPOL_RS07600	COG0739	heme binding
ACPOL_RS07605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACPOL_RS07620	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACPOL_RS07620	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACPOL_RS07640	COG0366	Alpha amylase catalytic
ACPOL_RS07650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACPOL_RS07680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPOL_RS07690	COG0359	binds to the 23S rRNA
ACPOL_RS07695	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACPOL_RS07700	COG0360	Binds together with S18 to 16S ribosomal RNA
ACPOL_RS07705	COG0193	aminoacyl-tRNA hydrolase activity
ACPOL_RS07710	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ACPOL_RS07715	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACPOL_RS07725	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACPOL_RS07740	COG0017	Asparaginyl-tRNA synthetase
ACPOL_RS07745	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACPOL_RS07750	COG1722	exodeoxyribonuclease VII activity
ACPOL_RS07775	COG0288	reversible hydration of carbon dioxide
ACPOL_RS07795	COG1982	Orn Lys Arg decarboxylase major
ACPOL_RS07835	COG1136	(ABC) transporter
ACPOL_RS07835	COG0577	efflux transmembrane transporter activity
ACPOL_RS07840	COG2376	Dihydroxyacetone kinase
ACPOL_RS07870	COG1695	Transcriptional regulator
ACPOL_RS07880	COG2032	superoxide dismutase activity
ACPOL_RS07890	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACPOL_RS07905	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ACPOL_RS07920	COG0606	chelatase, subunit chli
ACPOL_RS07925	COG1472	Belongs to the glycosyl hydrolase 3 family
ACPOL_RS07930	COG1760	l-serine dehydratase
ACPOL_RS07945	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ACPOL_RS07950	COG0484	heat shock protein binding
ACPOL_RS07955	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACPOL_RS07960	COG1420	regulation of RNA biosynthetic process
ACPOL_RS07965	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACPOL_RS07965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACPOL_RS07975	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ACPOL_RS07985	COG1335	isochorismatase
ACPOL_RS07995	COG4152	abc transporter atp-binding protein
ACPOL_RS08000	COG0110	maltose O-acetyltransferase activity
ACPOL_RS08005	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ACPOL_RS08015	COG3590	peptidase
ACPOL_RS08030	COG0463	Glycosyl transferase, family 2
ACPOL_RS08035	COG0616	signal peptide processing
ACPOL_RS08040	COG0776	regulation of translation
ACPOL_RS08065	COG1054	Belongs to the UPF0176 family
ACPOL_RS08080	COG3852	Histidine kinase
ACPOL_RS08090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACPOL_RS08095	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ACPOL_RS08100	COG1595	DNA-templated transcription, initiation
ACPOL_RS08110	COG3547	Transposase (IS116 IS110 IS902 family)
ACPOL_RS08120	COG1836	PFAM Integral membrane protein DUF92
ACPOL_RS08130	COG0583	DNA-binding transcription factor activity
ACPOL_RS08140	COG2957	Belongs to the agmatine deiminase family
ACPOL_RS08160	COG1136	(ABC) transporter
ACPOL_RS08160	COG0577	efflux transmembrane transporter activity
ACPOL_RS08170	COG0741	lytic transglycosylase activity
ACPOL_RS08170	COG1388	LysM domain
ACPOL_RS08175	COG0481	GTPase activity
ACPOL_RS08185	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACPOL_RS08200	COG0233	cytoplasmic translational termination
ACPOL_RS08235	COG0492	ferredoxin-NADP+ reductase activity
ACPOL_RS08245	COG2815	serine threonine protein kinase
ACPOL_RS08245	COG0515	serine threonine protein kinase
ACPOL_RS08285	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ACPOL_RS08300	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS08315	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ACPOL_RS08320	COG0477	Major facilitator Superfamily
ACPOL_RS08335	COG3345	alpha-galactosidase
ACPOL_RS08340	COG0673	inositol 2-dehydrogenase activity
ACPOL_RS08365	COG2022	thiamine diphosphate biosynthetic process
ACPOL_RS08365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACPOL_RS08370	COG0372	Belongs to the citrate synthase family
ACPOL_RS08385	COG1595	DNA-templated transcription, initiation
ACPOL_RS08400	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS08405	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS08420	COG0512	Glutamine amidotransferase of anthranilate synthase
ACPOL_RS08420	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACPOL_RS08425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACPOL_RS08425	COG0512	Glutamine amidotransferase of anthranilate synthase
ACPOL_RS08450	COG2124	cytochrome p450
ACPOL_RS08455	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS08460	COG1309	transcriptional regulator
ACPOL_RS08475	COG2226	methyltransferase
ACPOL_RS08475	COG1073	alpha beta
ACPOL_RS08490	COG0596	Alpha beta hydrolase
ACPOL_RS08540	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS08565	COG0300	oxidoreductase activity
ACPOL_RS08570	COG0114	fumarate hydratase activity
ACPOL_RS08575	COG0281	malic enzyme
ACPOL_RS08615	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACPOL_RS08620	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ACPOL_RS08625	COG2080	2 iron, 2 sulfur cluster binding
ACPOL_RS08630	COG1942	4-Oxalocrotonate Tautomerase
ACPOL_RS08635	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS08650	COG0667	Aldo Keto reductase
ACPOL_RS08655	COG0667	Aldo Keto reductase
ACPOL_RS08715	COG3250	beta-galactosidase activity
ACPOL_RS08720	COG3685	Protein conserved in bacteria
ACPOL_RS08745	COG5002	protein histidine kinase activity
ACPOL_RS08750	COG0745	RESPONSE REGULATOR receiver
ACPOL_RS08755	COG1247	-acetyltransferase
ACPOL_RS08760	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ACPOL_RS08770	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS08785	COG1410	methionine synthase
ACPOL_RS08785	COG0646	methionine synthase
ACPOL_RS08805	COG0626	cystathionine gamma-synthase activity
ACPOL_RS08900	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ACPOL_RS08930	COG0577	efflux transmembrane transporter activity
ACPOL_RS08955	COG0577	efflux transmembrane transporter activity
ACPOL_RS09020	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACPOL_RS09030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ACPOL_RS09040	COG0416	fatty acid biosynthetic process
ACPOL_RS09045	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ACPOL_RS09055	COG0352	thiamine-phosphate diphosphorylase activity
ACPOL_RS09080	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACPOL_RS09080	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ACPOL_RS09090	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACPOL_RS09095	COG0535	radical SAM domain protein
ACPOL_RS09100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACPOL_RS09120	COG1610	YqeY-like protein
ACPOL_RS09125	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACPOL_RS09145	COG2040	homocysteine
ACPOL_RS09150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACPOL_RS09155	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ACPOL_RS09170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACPOL_RS09175	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ACPOL_RS09180	COG1595	DNA-templated transcription, initiation
ACPOL_RS09220	COG1472	Belongs to the glycosyl hydrolase 3 family
ACPOL_RS09230	COG4585	Histidine kinase
ACPOL_RS09240	COG2197	response regulator
ACPOL_RS09250	COG3250	beta-galactosidase activity
ACPOL_RS09265	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ACPOL_RS09275	COG0159	tryptophan synthase activity
ACPOL_RS09280	COG0133	tryptophan synthase activity
ACPOL_RS09285	COG0135	phosphoribosylanthranilate isomerase activity
ACPOL_RS09295	COG0134	indole-3-glycerol-phosphate synthase activity
ACPOL_RS09300	COG1764	response to oxidative stress
ACPOL_RS09310	COG2234	aminopeptidase activity
ACPOL_RS09335	COG2226	methyltransferase
ACPOL_RS09340	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACPOL_RS09345	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACPOL_RS09350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ACPOL_RS09355	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACPOL_RS09360	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACPOL_RS09365	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACPOL_RS09380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ACPOL_RS09385	COG1923	regulation of RNA biosynthetic process
ACPOL_RS09405	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACPOL_RS09420	COG1609	Transcriptional regulator
ACPOL_RS09445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACPOL_RS09450	COG0805	protein transport
ACPOL_RS09465	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACPOL_RS09470	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ACPOL_RS09475	COG0594	ribonuclease P activity
ACPOL_RS09480	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ACPOL_RS09485	COG0706	membrane insertase activity
ACPOL_RS09500	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ACPOL_RS09505	COG4251	negative regulation of phosphorylation
ACPOL_RS09510	COG2197	response regulator
ACPOL_RS09515	COG5001	Diguanylate cyclase
ACPOL_RS09515	COG5002	protein histidine kinase activity
ACPOL_RS09515	COG3447	MASE1 domain protein
ACPOL_RS09565	COG2814	Major facilitator Superfamily
ACPOL_RS09575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACPOL_RS09610	COG2132	Multicopper oxidase
ACPOL_RS09625	COG1131	(ABC) transporter
ACPOL_RS09630	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ACPOL_RS09635	COG0540	Belongs to the ATCase OTCase family
ACPOL_RS09640	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACPOL_RS09650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACPOL_RS09665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACPOL_RS09670	COG0776	regulation of translation
ACPOL_RS09710	COG1695	Transcriptional regulator
ACPOL_RS09715	COG1131	(ABC) transporter
ACPOL_RS09740	COG4585	Histidine kinase
ACPOL_RS09745	COG2197	response regulator
ACPOL_RS09765	COG0012	GTP binding
ACPOL_RS09780	COG5000	phosphorelay sensor kinase activity
ACPOL_RS09785	COG2204	response regulator
ACPOL_RS09790	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ACPOL_RS09850	COG1472	Belongs to the glycosyl hydrolase 3 family
ACPOL_RS09870	COG0515	serine threonine protein kinase
ACPOL_RS09870	COG2815	serine threonine protein kinase
ACPOL_RS09885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACPOL_RS09900	COG2337	Toxic component of a toxin-antitoxin (TA) module
ACPOL_RS09925	COG0632	four-way junction helicase activity
ACPOL_RS09935	COG3046	protein related to deoxyribodipyrimidine photolyase
ACPOL_RS09945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACPOL_RS09955	COG2261	transglycosylase associated protein
ACPOL_RS09980	COG3830	Belongs to the UPF0237 family
ACPOL_RS09980	COG0560	Phosphoserine phosphatase
ACPOL_RS09985	COG0793	Belongs to the peptidase S41A family
ACPOL_RS09990	COG4702	Belongs to the UPF0303 family
ACPOL_RS09995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACPOL_RS10000	COG3481	metal-dependent phosphohydrolase, HD sub domain
ACPOL_RS10020	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACPOL_RS10025	COG0242	peptide deformylase activity
ACPOL_RS10035	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ACPOL_RS10035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACPOL_RS10040	COG2815	serine threonine protein kinase
ACPOL_RS10040	COG0515	serine threonine protein kinase
ACPOL_RS10050	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ACPOL_RS10070	COG1695	Transcriptional regulator
ACPOL_RS10075	COG1136	(ABC) transporter
ACPOL_RS10075	COG0577	efflux transmembrane transporter activity
ACPOL_RS10110	COG2264	protein methyltransferase activity
ACPOL_RS10115	COG1215	transferase activity, transferring glycosyl groups
ACPOL_RS10120	COG0110	maltose O-acetyltransferase activity
ACPOL_RS10145	COG0028	Belongs to the TPP enzyme family
ACPOL_RS10160	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS10175	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ACPOL_RS10180	COG2089	acid synthase
ACPOL_RS10190	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACPOL_RS10200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACPOL_RS10205	COG2755	lipolytic protein G-D-S-L family
ACPOL_RS10205	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACPOL_RS10225	COG1215	transferase activity, transferring glycosyl groups
ACPOL_RS10235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACPOL_RS10245	COG0564	pseudouridine synthase activity
ACPOL_RS10260	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACPOL_RS10270	COG1902	pentaerythritol trinitrate reductase activity
ACPOL_RS10285	COG0443	Heat shock 70 kDa protein
ACPOL_RS10290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACPOL_RS10305	COG0657	acetylesterase activity
ACPOL_RS10305	COG2755	lipolytic protein G-D-S-L family
ACPOL_RS10310	COG3345	alpha-galactosidase
ACPOL_RS10325	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS10335	COG2706	6-phosphogluconolactonase activity
ACPOL_RS10340	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACPOL_RS10380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACPOL_RS10395	COG2132	Multicopper oxidase
ACPOL_RS10415	COG0268	Binds directly to 16S ribosomal RNA
ACPOL_RS10420	COG1228	amidohydrolase
ACPOL_RS10430	COG1228	amidohydrolase
ACPOL_RS10445	COG0681	Belongs to the peptidase S26 family
ACPOL_RS10450	COG1612	heme a metabolic process
ACPOL_RS10450	COG0109	protoheme IX farnesyltransferase activity
ACPOL_RS10455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACPOL_RS10460	COG0745	RESPONSE REGULATOR receiver
ACPOL_RS10525	COG1475	DNA binding
ACPOL_RS10530	COG1192	Involved in chromosome partitioning
ACPOL_RS10535	COG0357	Ribosomal RNA small subunit methyltransferase G
ACPOL_RS10540	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ACPOL_RS10555	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ACPOL_RS10560	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ACPOL_RS10580	COG0799	negative regulation of ribosome biogenesis
ACPOL_RS10585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ACPOL_RS10590	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ACPOL_RS10600	COG0343	queuine tRNA-ribosyltransferase activity
ACPOL_RS10605	COG1862	Preprotein translocase
ACPOL_RS10610	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACPOL_RS10615	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACPOL_RS10635	COG0848	biopolymer transport protein
ACPOL_RS10645	COG0439	Biotin carboxylase
ACPOL_RS10650	COG5016	pyruvate
ACPOL_RS10650	COG0511	ligase activity, forming carbon-carbon bonds
ACPOL_RS10670	COG3852	Histidine kinase
ACPOL_RS10675	COG0402	S-adenosylhomocysteine deaminase activity
ACPOL_RS10705	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ACPOL_RS10740	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACPOL_RS10745	COG4535	Mg2 and Co2 transporter CorC
ACPOL_RS10750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACPOL_RS10760	COG0154	amidase activity
ACPOL_RS10765	COG1368	sulfuric ester hydrolase activity
ACPOL_RS10770	COG0488	(ABC) transporter
ACPOL_RS10795	COG1138	Cytochrome C-type biogenesis protein
ACPOL_RS10810	COG5654	RES domain protein
ACPOL_RS10835	COG1132	(ABC) transporter
ACPOL_RS10840	COG0501	Belongs to the peptidase M48B family
ACPOL_RS10865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACPOL_RS10880	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ACPOL_RS10885	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS10930	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS10955	COG1940	carbohydrate kinase activity
ACPOL_RS10960	COG2814	Major facilitator Superfamily
ACPOL_RS10970	COG1940	carbohydrate kinase activity
ACPOL_RS10980	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ACPOL_RS11035	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACPOL_RS11045	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACPOL_RS11050	COG0531	amino acid
ACPOL_RS11055	COG0515	serine threonine protein kinase
ACPOL_RS11055	COG2815	serine threonine protein kinase
ACPOL_RS11075	COG1556	Lactate utilization protein
ACPOL_RS11080	COG1139	Iron-sulfur cluster binding protein
ACPOL_RS11085	COG0247	lactate metabolic process
ACPOL_RS11105	COG1309	transcriptional regulator
ACPOL_RS11150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACPOL_RS11160	COG1573	uracil-dna glycosylase
ACPOL_RS11180	COG0673	inositol 2-dehydrogenase activity
ACPOL_RS11190	COG1560	Kdo2-lipid A biosynthetic process
ACPOL_RS11200	COG0717	Belongs to the dCTP deaminase family
ACPOL_RS11215	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ACPOL_RS11220	COG1573	uracil-dna glycosylase
ACPOL_RS11225	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACPOL_RS11235	COG0194	GDP metabolic process
ACPOL_RS11240	COG1561	YicC-like family, N-terminal region
ACPOL_RS11245	COG1132	(ABC) transporter
ACPOL_RS11250	COG1660	Displays ATPase and GTPase activities
ACPOL_RS11265	COG1137	ATPase activity
ACPOL_RS11285	COG1228	amidohydrolase
ACPOL_RS11295	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ACPOL_RS11305	COG2351	hydroxyisourate hydrolase activity
ACPOL_RS11330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACPOL_RS11335	COG0590	tRNA wobble adenosine to inosine editing
ACPOL_RS11360	COG1132	(ABC) transporter
ACPOL_RS11380	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ACPOL_RS11385	COG0058	SHG alpha-glucan phosphorylase activity
ACPOL_RS11410	COG0131	Imidazoleglycerol-phosphate dehydratase
ACPOL_RS11410	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ACPOL_RS11415	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACPOL_RS11485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACPOL_RS11495	COG3253	May function as heme-dependent peroxidase
ACPOL_RS11510	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS11515	COG3387	PFAM Glycoside hydrolase 15-related
ACPOL_RS11535	COG1793	dna ligase
ACPOL_RS11565	COG1228	amidohydrolase
ACPOL_RS11570	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ACPOL_RS11580	COG1522	sequence-specific DNA binding
ACPOL_RS11600	COG1505	serine-type exopeptidase activity
ACPOL_RS11605	COG2205	protein histidine kinase activity
ACPOL_RS11610	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACPOL_RS11615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACPOL_RS11615	COG1648	precorrin-2 dehydrogenase activity
ACPOL_RS11620	COG2855	membrane
ACPOL_RS11630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACPOL_RS11635	COG1609	Transcriptional regulator
ACPOL_RS11655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACPOL_RS11660	COG0573	inorganic phosphate transmembrane transporter activity
ACPOL_RS11665	COG0581	inorganic phosphate transmembrane transporter activity
ACPOL_RS11670	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACPOL_RS11680	COG1074	ATP-dependent DNA helicase activity
ACPOL_RS11695	COG3265	gluconokinase activity
ACPOL_RS11715	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ACPOL_RS11760	COG1295	ribonuclease BN
ACPOL_RS11840	COG2188	Transcriptional regulator
ACPOL_RS11870	COG1605	Chorismate mutase
ACPOL_RS11880	COG2197	response regulator
ACPOL_RS11885	COG2203	Gaf domain
ACPOL_RS11885	COG4585	Histidine kinase
ACPOL_RS11895	COG0745	RESPONSE REGULATOR receiver
ACPOL_RS11895	COG2205	protein histidine kinase activity
ACPOL_RS11895	COG4191	Histidine kinase
ACPOL_RS11905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACPOL_RS11905	COG3321	synthase
ACPOL_RS11905	COG0604	alcohol dehydrogenase
ACPOL_RS11905	COG4221	oxidoreductase activity
ACPOL_RS11915	COG2205	protein histidine kinase activity
ACPOL_RS11915	COG3292	Two component regulator propeller
ACPOL_RS11915	COG0745	RESPONSE REGULATOR receiver
ACPOL_RS11920	COG4447	cellulose binding
ACPOL_RS11935	COG5002	protein histidine kinase activity
ACPOL_RS11990	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ACPOL_RS12010	COG2207	Transcriptional regulator
ACPOL_RS12015	COG0154	amidase activity
ACPOL_RS12020	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS12050	COG1309	transcriptional regulator
ACPOL_RS12055	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS12085	COG3537	Alpha-1,2-mannosidase
ACPOL_RS12100	COG1609	Transcriptional regulator
ACPOL_RS12125	COG0644	oxidoreductase
ACPOL_RS12135	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ACPOL_RS12145	COG1309	transcriptional regulator
ACPOL_RS12160	COG0702	epimerase
ACPOL_RS12170	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS12175	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS12200	COG3706	GGDEF domain
ACPOL_RS12245	COG1136	(ABC) transporter
ACPOL_RS12245	COG0577	efflux transmembrane transporter activity
ACPOL_RS12295	COG2205	protein histidine kinase activity
ACPOL_RS12375	COG0583	DNA-binding transcription factor activity
ACPOL_RS12430	COG1127	ABC transporter
ACPOL_RS12435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACPOL_RS12445	COG3387	PFAM Glycoside hydrolase 15-related
ACPOL_RS12455	COG0596	Alpha beta hydrolase
ACPOL_RS12460	COG3547	Transposase (IS116 IS110 IS902 family)
ACPOL_RS12495	COG3177	Filamentation induced by cAMP protein fic
ACPOL_RS12595	COG0667	Aldo Keto reductase
ACPOL_RS12600	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS12610	COG0517	IMP dehydrogenase activity
ACPOL_RS12615	COG4974	Belongs to the 'phage' integrase family
ACPOL_RS12635	COG0596	Alpha beta hydrolase
ACPOL_RS12640	COG0583	DNA-binding transcription factor activity
ACPOL_RS12675	COG1252	NADH dehydrogenase
ACPOL_RS12715	COG2814	Major facilitator Superfamily
ACPOL_RS12720	COG2814	Major facilitator Superfamily
ACPOL_RS12725	COG1940	carbohydrate kinase activity
ACPOL_RS12745	COG2814	Major facilitator Superfamily
ACPOL_RS12780	COG3250	beta-galactosidase activity
ACPOL_RS12785	COG2706	6-phosphogluconolactonase activity
ACPOL_RS12795	COG3537	Alpha-1,2-mannosidase
ACPOL_RS12845	COG1733	regulation of RNA biosynthetic process
ACPOL_RS12855	COG0517	IMP dehydrogenase activity
ACPOL_RS12875	COG0517	IMP dehydrogenase activity
ACPOL_RS12880	COG4974	Belongs to the 'phage' integrase family
ACPOL_RS12895	COG1309	transcriptional regulator
ACPOL_RS12915	COG4974	Belongs to the 'phage' integrase family
ACPOL_RS12920	COG0517	IMP dehydrogenase activity
ACPOL_RS12935	COG0583	DNA-binding transcription factor activity
ACPOL_RS12940	COG0673	inositol 2-dehydrogenase activity
ACPOL_RS13000	COG1733	regulation of RNA biosynthetic process
ACPOL_RS13005	COG1475	DNA binding
ACPOL_RS13025	COG0667	Aldo Keto reductase
ACPOL_RS13030	COG0702	epimerase
ACPOL_RS13085	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS13085	COG0604	alcohol dehydrogenase
ACPOL_RS13085	COG3321	synthase
ACPOL_RS13090	COG2226	methyltransferase
ACPOL_RS13125	COG0596	Alpha beta hydrolase
ACPOL_RS13130	COG2207	Transcriptional regulator
ACPOL_RS13150	COG1309	transcriptional regulator
ACPOL_RS13155	COG1819	glycosyl
ACPOL_RS13175	COG2132	Multicopper oxidase
ACPOL_RS13195	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS13210	COG3537	Alpha-1,2-mannosidase
ACPOL_RS13220	COG0366	Alpha amylase catalytic
ACPOL_RS13240	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACPOL_RS13245	COG1127	ABC transporter
ACPOL_RS13280	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS13295	COG0667	Aldo Keto reductase
ACPOL_RS13335	COG0667	Aldo Keto reductase
ACPOL_RS13345	COG0596	Alpha beta hydrolase
ACPOL_RS13375	COG3250	beta-galactosidase activity
ACPOL_RS13390	COG3250	beta-galactosidase activity
ACPOL_RS13395	COG1609	Transcriptional regulator
ACPOL_RS13405	COG3537	Alpha-1,2-mannosidase
ACPOL_RS13440	COG3344	reverse transcriptase
ACPOL_RS13535	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS13545	COG0693	protein deglycase activity
ACPOL_RS13555	COG1846	Transcriptional regulator
ACPOL_RS13595	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS13605	COG3275	phosphorelay sensor kinase activity
ACPOL_RS13610	COG3279	Response regulator of the LytR AlgR family
ACPOL_RS13625	COG2910	NAD(P)H-binding
ACPOL_RS13645	COG0454	-acetyltransferase
ACPOL_RS13665	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ACPOL_RS13690	COG2267	carboxylic ester hydrolase activity
ACPOL_RS13700	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACPOL_RS13705	COG2249	NAD(P)H dehydrogenase (quinone) activity
ACPOL_RS13710	COG1733	regulation of RNA biosynthetic process
ACPOL_RS13715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACPOL_RS13725	COG2132	Multicopper oxidase
ACPOL_RS13740	COG0076	glutamate decarboxylase activity
ACPOL_RS13805	COG1309	transcriptional regulator
ACPOL_RS13815	COG0517	IMP dehydrogenase activity
ACPOL_RS13825	COG4974	Belongs to the 'phage' integrase family
ACPOL_RS13830	COG0517	IMP dehydrogenase activity
ACPOL_RS13850	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS13875	COG5002	protein histidine kinase activity
ACPOL_RS13885	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ACPOL_RS13900	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACPOL_RS13910	COG2140	Oxalate decarboxylase
ACPOL_RS13985	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ACPOL_RS14005	COG2204	response regulator
ACPOL_RS14055	COG2814	Major facilitator Superfamily
ACPOL_RS14065	COG1566	PFAM secretion protein HlyD family protein
ACPOL_RS14075	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS14100	COG3344	reverse transcriptase
ACPOL_RS14130	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ACPOL_RS14135	COG0783	Belongs to the Dps family
ACPOL_RS14185	COG0708	Exodeoxyribonuclease III
ACPOL_RS14205	COG0583	DNA-binding transcription factor activity
ACPOL_RS14210	COG0702	epimerase
ACPOL_RS14220	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS14230	COG2267	carboxylic ester hydrolase activity
ACPOL_RS14250	COG1733	regulation of RNA biosynthetic process
ACPOL_RS14265	COG1902	pentaerythritol trinitrate reductase activity
ACPOL_RS14305	COG4585	Histidine kinase
ACPOL_RS14310	COG4977	sequence-specific DNA binding
ACPOL_RS14315	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS14325	COG1063	alcohol dehydrogenase
ACPOL_RS14330	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS14335	COG1228	amidohydrolase
ACPOL_RS14365	COG1063	alcohol dehydrogenase
ACPOL_RS14370	COG0667	Aldo Keto reductase
ACPOL_RS14375	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS14415	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACPOL_RS14445	COG0604	alcohol dehydrogenase
ACPOL_RS14460	COG0242	peptide deformylase activity
ACPOL_RS14530	COG1309	transcriptional regulator
ACPOL_RS14535	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS14555	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS14570	COG0174	glutamine synthetase
ACPOL_RS14580	COG0004	ammonium transporteR
ACPOL_RS14605	COG0515	serine threonine protein kinase
ACPOL_RS14610	COG0631	protein serine/threonine phosphatase activity
ACPOL_RS14615	COG0531	amino acid
ACPOL_RS14625	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ACPOL_RS14630	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACPOL_RS14635	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACPOL_RS14645	COG0477	Major facilitator Superfamily
ACPOL_RS14650	COG0457	Tetratricopeptide repeat
ACPOL_RS14655	COG2814	Major facilitator Superfamily
ACPOL_RS14660	COG0673	inositol 2-dehydrogenase activity
ACPOL_RS14680	COG4948	Mandelate Racemase Muconate Lactonizing
ACPOL_RS14695	COG2271	Major facilitator Superfamily
ACPOL_RS14705	COG0667	Aldo Keto reductase
ACPOL_RS14715	COG0667	Aldo Keto reductase
ACPOL_RS14720	COG4948	Mandelate Racemase Muconate Lactonizing
ACPOL_RS14735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACPOL_RS14745	COG2814	Major facilitator Superfamily
ACPOL_RS14780	COG0583	DNA-binding transcription factor activity
ACPOL_RS14815	COG0741	lytic transglycosylase activity
ACPOL_RS14825	COG1595	DNA-templated transcription, initiation
ACPOL_RS14835	COG0009	L-threonylcarbamoyladenylate synthase
ACPOL_RS14845	COG0470	DNA polymerase III
ACPOL_RS14850	COG2124	cytochrome p450
ACPOL_RS14855	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACPOL_RS14860	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACPOL_RS14865	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACPOL_RS14880	COG3240	lipase activity
ACPOL_RS14885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACPOL_RS14890	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACPOL_RS14975	COG0673	inositol 2-dehydrogenase activity
ACPOL_RS14990	COG1012	belongs to the aldehyde dehydrogenase family
ACPOL_RS15005	COG3300	MHYT domain
ACPOL_RS15005	COG5001	Diguanylate cyclase
ACPOL_RS15020	COG0640	Transcriptional regulator
ACPOL_RS15100	COG3220	belongs to the UPF0276 family
ACPOL_RS15130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACPOL_RS15160	COG0673	inositol 2-dehydrogenase activity
ACPOL_RS15175	COG2271	Major facilitator Superfamily
ACPOL_RS15185	COG0673	inositol 2-dehydrogenase activity
ACPOL_RS15190	COG0363	glucosamine-6-phosphate deaminase activity
ACPOL_RS15195	COG1609	Transcriptional regulator
ACPOL_RS15230	COG1349	DNA-binding transcription factor activity
ACPOL_RS15430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPOL_RS15445	COG1609	Transcriptional regulator
ACPOL_RS15465	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ACPOL_RS15505	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS15515	COG2267	carboxylic ester hydrolase activity
ACPOL_RS15595	COG0515	serine threonine protein kinase
ACPOL_RS15595	COG2815	serine threonine protein kinase
ACPOL_RS15600	COG4974	Belongs to the 'phage' integrase family
ACPOL_RS15655	COG0305	Participates in initiation and elongation during chromosome replication
ACPOL_RS15720	COG2814	Major facilitator Superfamily
ACPOL_RS15735	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACPOL_RS15755	COG0577	efflux transmembrane transporter activity
ACPOL_RS15755	COG1136	(ABC) transporter
ACPOL_RS15770	COG1295	ribonuclease BN
ACPOL_RS15780	COG1960	acyl-CoA dehydrogenase activity
ACPOL_RS15785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACPOL_RS15790	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACPOL_RS15805	COG2204	response regulator
ACPOL_RS15810	COG5002	protein histidine kinase activity
ACPOL_RS15825	COG2252	PERMEase
ACPOL_RS15830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACPOL_RS15840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACPOL_RS15860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACPOL_RS15870	COG1609	Transcriptional regulator
ACPOL_RS15885	COG2942	2-epimerase
ACPOL_RS15900	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ACPOL_RS15915	COG2706	6-phosphogluconolactonase activity
ACPOL_RS15925	COG1082	Xylose isomerase domain protein TIM barrel
ACPOL_RS15955	COG1566	PFAM secretion protein HlyD family protein
ACPOL_RS15985	COG1653	transport
ACPOL_RS15990	COG4585	Histidine kinase
ACPOL_RS15995	COG2197	response regulator
ACPOL_RS16005	COG3604	Transcriptional regulator
ACPOL_RS16025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACPOL_RS16055	COG1414	Transcriptional regulator
ACPOL_RS16075	COG0728	peptidoglycan biosynthetic process
ACPOL_RS16090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACPOL_RS16105	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACPOL_RS16110	COG0237	dephospho-CoA kinase activity
ACPOL_RS16130	COG1570	exodeoxyribonuclease VII activity
ACPOL_RS16200	COG0557	exoribonuclease II activity
ACPOL_RS16215	COG0539	negative regulation of cytoplasmic translation
ACPOL_RS16220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACPOL_RS16225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACPOL_RS16230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACPOL_RS16245	COG2132	Multicopper oxidase
ACPOL_RS16255	COG2814	Major facilitator Superfamily
ACPOL_RS16260	COG1940	carbohydrate kinase activity
ACPOL_RS16270	COG2203	Gaf domain
ACPOL_RS16270	COG3706	GGDEF domain
ACPOL_RS16270	COG4251	negative regulation of phosphorylation
ACPOL_RS16270	COG5001	Diguanylate cyclase
ACPOL_RS16285	COG0515	serine threonine protein kinase
ACPOL_RS16285	COG2815	serine threonine protein kinase
ACPOL_RS16290	COG1360	Flagellar Motor Protein
ACPOL_RS16295	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ACPOL_RS16315	COG1012	belongs to the aldehyde dehydrogenase family
ACPOL_RS16320	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACPOL_RS16325	COG0617	tRNA 3'-terminal CCA addition
ACPOL_RS16330	COG2081	HI0933 family
ACPOL_RS16340	COG0643	Histidine kinase
ACPOL_RS16340	COG0784	Response regulator, receiver
ACPOL_RS16340	COG2198	Histidine kinase
ACPOL_RS16345	COG0835	chemotaxis
ACPOL_RS16360	COG0745	RESPONSE REGULATOR receiver
ACPOL_RS16365	COG2201	protein-glutamate methylesterase activity
ACPOL_RS16370	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACPOL_RS16380	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ACPOL_RS16385	COG0045	succinate-CoA ligase (ADP-forming) activity
ACPOL_RS16390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACPOL_RS16410	COG1994	Peptidase M50
ACPOL_RS16415	COG0180	Tryptophanyl-tRNA synthetase
ACPOL_RS16425	COG2814	Major facilitator Superfamily
ACPOL_RS16435	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACPOL_RS16435	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACPOL_RS16450	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ACPOL_RS16460	COG1309	transcriptional regulator
ACPOL_RS16470	COG1136	(ABC) transporter
ACPOL_RS16500	COG0506	proline dehydrogenase activity
ACPOL_RS16570	COG0489	protein tyrosine kinase activity
ACPOL_RS16625	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ACPOL_RS16645	COG0457	Tetratricopeptide repeat
ACPOL_RS16655	COG2132	Multicopper oxidase
ACPOL_RS16660	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACPOL_RS16665	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACPOL_RS16670	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ACPOL_RS16680	COG1012	belongs to the aldehyde dehydrogenase family
ACPOL_RS16705	COG1297	OPT oligopeptide transporter protein
ACPOL_RS16720	COG1957	nucleoside hydrolase
ACPOL_RS16730	COG5265	(ABC) transporter
ACPOL_RS16750	COG4585	Histidine kinase
ACPOL_RS16755	COG2197	response regulator
ACPOL_RS16765	COG3940	Belongs to the glycosyl hydrolase 43 family
ACPOL_RS16780	COG3234	Protein of unknown function (DUF1175)
ACPOL_RS16785	COG2373	Large extracellular alpha-helical protein
ACPOL_RS16820	COG1309	transcriptional regulator
ACPOL_RS16830	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS16845	COG1309	transcriptional regulator
ACPOL_RS16850	COG0251	oxidation-reduction process
ACPOL_RS16910	COG3813	Protein conserved in bacteria
ACPOL_RS16915	COG0640	Transcriptional regulator
ACPOL_RS16925	COG4221	oxidoreductase activity
ACPOL_RS16935	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ACPOL_RS17005	COG0583	DNA-binding transcription factor activity
ACPOL_RS17015	COG2258	MOSC domain
ACPOL_RS17030	COG0583	DNA-binding transcription factor activity
ACPOL_RS17040	COG1032	radical SAM domain protein
ACPOL_RS17045	COG1032	radical SAM domain protein
ACPOL_RS17070	COG2226	methyltransferase
ACPOL_RS17075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACPOL_RS17110	COG0183	Belongs to the thiolase family
ACPOL_RS17120	COG1621	beta-fructofuranosidase activity
ACPOL_RS17135	COG0589	response to stress
ACPOL_RS17165	COG1012	belongs to the aldehyde dehydrogenase family
ACPOL_RS17210	COG1177	transmembrane transport
ACPOL_RS17215	COG1231	oxidoreductase activity
ACPOL_RS17220	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ACPOL_RS17230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACPOL_RS17250	COG0358	DNA primase activity
ACPOL_RS17255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACPOL_RS17260	COG0583	DNA-binding transcription factor activity
ACPOL_RS17265	COG0456	acetyltransferase
ACPOL_RS17290	COG0187	DNA topoisomerase II activity
ACPOL_RS17305	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ACPOL_RS17310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ACPOL_RS17315	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ACPOL_RS17325	COG0105	UTP biosynthetic process
ACPOL_RS17330	COG0667	Aldo Keto reductase
ACPOL_RS17340	COG0745	RESPONSE REGULATOR receiver
ACPOL_RS17350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACPOL_RS17380	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS17390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACPOL_RS17405	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACPOL_RS17430	COG0081	regulation of translation
ACPOL_RS17435	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACPOL_RS17440	COG0222	ribosome binding
ACPOL_RS17445	COG0085	RNA polymerase activity
ACPOL_RS17450	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACPOL_RS17460	COG2442	InterPro IPR007367
ACPOL_RS17495	COG0577	efflux transmembrane transporter activity
ACPOL_RS17505	COG0667	Aldo Keto reductase
ACPOL_RS17515	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ACPOL_RS17520	COG3250	beta-galactosidase activity
ACPOL_RS17535	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS17540	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS17550	COG0528	UMP kinase activity
ACPOL_RS17560	COG0386	Belongs to the glutathione peroxidase family
ACPOL_RS17615	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACPOL_RS17620	COG0052	Belongs to the universal ribosomal protein uS2 family
ACPOL_RS17625	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACPOL_RS17630	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACPOL_RS17640	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACPOL_RS17645	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACPOL_RS17670	COG2814	Major facilitator Superfamily
ACPOL_RS17710	COG1792	Involved in formation and maintenance of cell shape
ACPOL_RS17720	COG0768	penicillin binding
ACPOL_RS17725	COG0772	Belongs to the SEDS family
ACPOL_RS17730	COG1530	ribonuclease E activity
ACPOL_RS17730	COG1530	ribonuclease E activity
ACPOL_RS17745	COG0006	proline dipeptidase activity
ACPOL_RS17755	COG4106	trans-aconitate 2-methyltransferase activity
ACPOL_RS17770	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACPOL_RS17775	COG0456	acetyltransferase
ACPOL_RS17790	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ACPOL_RS17795	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ACPOL_RS17805	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACPOL_RS17810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACPOL_RS17820	COG1446	asparaginase
ACPOL_RS17825	COG0424	maF-like protein
ACPOL_RS17835	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ACPOL_RS17845	COG0537	adenosine 5'-monophosphoramidase activity
ACPOL_RS17855	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACPOL_RS17860	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACPOL_RS17865	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ACPOL_RS17880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACPOL_RS17890	COG0215	cysteine-tRNA ligase activity
ACPOL_RS17895	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACPOL_RS17920	COG2318	DinB family
ACPOL_RS17930	COG0312	modulator of DNA gyrase
ACPOL_RS17965	COG0577	efflux transmembrane transporter activity
ACPOL_RS17965	COG1136	(ABC) transporter
ACPOL_RS17970	COG0028	Belongs to the TPP enzyme family
ACPOL_RS17975	COG0477	Major facilitator Superfamily
ACPOL_RS18005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ACPOL_RS18015	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACPOL_RS18020	COG0740	serine-type endopeptidase activity
ACPOL_RS18025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACPOL_RS18030	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACPOL_RS18040	COG1609	Transcriptional regulator
ACPOL_RS18050	COG1063	alcohol dehydrogenase
ACPOL_RS18055	COG0738	Major facilitator superfamily
ACPOL_RS18060	COG4948	Mandelate Racemase Muconate Lactonizing
ACPOL_RS18080	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ACPOL_RS18085	COG0367	asparagine synthase
ACPOL_RS18125	COG1562	ergosterol biosynthetic process
ACPOL_RS18130	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS18135	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS18150	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS18155	COG1309	transcriptional regulator
ACPOL_RS18180	COG2010	Cytochrome c
ACPOL_RS18215	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACPOL_RS18225	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACPOL_RS18225	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACPOL_RS18260	COG1609	Transcriptional regulator
ACPOL_RS18270	COG1472	Belongs to the glycosyl hydrolase 3 family
ACPOL_RS18275	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS18295	COG1063	alcohol dehydrogenase
ACPOL_RS18300	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS18310	COG3534	alpha-L-arabinofuranosidase
ACPOL_RS18325	COG0667	Aldo Keto reductase
ACPOL_RS18335	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ACPOL_RS18340	COG0735	belongs to the Fur family
ACPOL_RS18375	COG3850	Histidine kinase
ACPOL_RS18375	COG0642	Histidine kinase
ACPOL_RS18380	COG1082	Xylose isomerase domain protein TIM barrel
ACPOL_RS18395	COG1609	Transcriptional regulator
ACPOL_RS18400	COG0596	Alpha beta hydrolase
ACPOL_RS18415	COG1725	Transcriptional regulator
ACPOL_RS18445	COG1733	regulation of RNA biosynthetic process
ACPOL_RS18475	COG2801	Transposase and inactivated derivatives
ACPOL_RS18480	COG3547	Transposase (IS116 IS110 IS902 family)
ACPOL_RS18495	COG2815	serine threonine protein kinase
ACPOL_RS18495	COG0515	serine threonine protein kinase
ACPOL_RS18580	COG1595	DNA-templated transcription, initiation
ACPOL_RS18595	COG2140	Oxalate decarboxylase
ACPOL_RS18620	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACPOL_RS18625	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACPOL_RS18645	COG1506	peptidase
ACPOL_RS18645	COG0823	Involved in the tonB-independent uptake of proteins
ACPOL_RS18665	COG0673	inositol 2-dehydrogenase activity
ACPOL_RS18695	COG3408	Glycogen debranching enzyme
ACPOL_RS18695	COG3119	arylsulfatase activity
ACPOL_RS18710	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ACPOL_RS18715	COG0022	dehydrogenase e1 component
ACPOL_RS18740	COG2211	Major facilitator Superfamily
ACPOL_RS18745	COG0322	excinuclease ABC activity
ACPOL_RS18755	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACPOL_RS18765	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACPOL_RS18785	COG0778	Nitroreductase
ACPOL_RS18805	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ACPOL_RS18810	COG0438	transferase activity, transferring glycosyl groups
ACPOL_RS18825	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACPOL_RS18825	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACPOL_RS18830	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ACPOL_RS18840	COG0859	PFAM glycosyl transferase family 9
ACPOL_RS18885	COG0488	(ABC) transporter
ACPOL_RS18900	COG0488	(ABC) transporter
ACPOL_RS18910	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ACPOL_RS18920	COG3622	Belongs to the hyi family
ACPOL_RS18925	COG2226	methyltransferase
ACPOL_RS18930	COG3685	Protein conserved in bacteria
ACPOL_RS18935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACPOL_RS18940	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACPOL_RS18945	COG0772	Belongs to the SEDS family
ACPOL_RS18950	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACPOL_RS18960	COG0504	CTP synthase activity
ACPOL_RS19000	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACPOL_RS19005	COG1254	Belongs to the acylphosphatase family
ACPOL_RS19015	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACPOL_RS19025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACPOL_RS19030	COG0406	alpha-ribazole phosphatase activity
ACPOL_RS19035	COG0058	SHG alpha-glucan phosphorylase activity
ACPOL_RS19080	COG2135	peptidase activity
ACPOL_RS19085	COG0583	DNA-binding transcription factor activity
ACPOL_RS19095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACPOL_RS19105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACPOL_RS19110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACPOL_RS19115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACPOL_RS19180	COG4977	sequence-specific DNA binding
ACPOL_RS19210	COG0667	Aldo Keto reductase
ACPOL_RS19240	COG0784	Response regulator, receiver
ACPOL_RS19240	COG2205	protein histidine kinase activity
ACPOL_RS19240	COG5002	protein histidine kinase activity
ACPOL_RS19255	COG0535	radical SAM domain protein
ACPOL_RS19305	COG1846	Transcriptional regulator
ACPOL_RS19310	COG0702	epimerase
ACPOL_RS19340	COG4221	oxidoreductase activity
ACPOL_RS19350	COG2226	methyltransferase
ACPOL_RS19355	COG0477	Major facilitator Superfamily
ACPOL_RS19375	COG0028	Belongs to the TPP enzyme family
ACPOL_RS19395	COG0154	amidase activity
ACPOL_RS19400	COG0154	amidase activity
ACPOL_RS19420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACPOL_RS19455	COG0667	Aldo Keto reductase
ACPOL_RS19475	COG0113	porphobilinogen synthase activity
ACPOL_RS19480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACPOL_RS19485	COG1598	PFAM Uncharacterised protein family UPF0150
ACPOL_RS19490	COG0321	lipoyl(octanoyl) transferase activity
ACPOL_RS19495	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACPOL_RS19500	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ACPOL_RS19505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACPOL_RS19615	COG2770	Histidine kinase
ACPOL_RS19615	COG2208	phosphoserine phosphatase activity
ACPOL_RS19630	COG1611	Belongs to the LOG family
ACPOL_RS19640	COG1217	gtp-binding protein TYPA
ACPOL_RS19655	COG5002	protein histidine kinase activity
ACPOL_RS19660	COG0745	RESPONSE REGULATOR receiver
ACPOL_RS19670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACPOL_RS19710	COG3710	Transcriptional regulator
ACPOL_RS19720	COG2267	carboxylic ester hydrolase activity
ACPOL_RS19730	COG0247	lactate metabolic process
ACPOL_RS19765	COG2169	Transcriptional regulator
ACPOL_RS19775	COG2197	response regulator
ACPOL_RS19780	COG4585	Histidine kinase
ACPOL_RS19785	COG3250	beta-galactosidase activity
ACPOL_RS19815	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ACPOL_RS19825	COG0583	DNA-binding transcription factor activity
ACPOL_RS19840	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ACPOL_RS19870	COG2154	pterin-4-alpha-carbinolamine dehydratase
ACPOL_RS19875	COG2199	diguanylate cyclase activity
ACPOL_RS19875	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ACPOL_RS19880	COG1595	DNA-templated transcription, initiation
ACPOL_RS19905	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ACPOL_RS19915	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ACPOL_RS19920	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACPOL_RS19925	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACPOL_RS19930	COG0509	glycine decarboxylation via glycine cleavage system
ACPOL_RS19935	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACPOL_RS19945	COG0739	heme binding
ACPOL_RS19995	COG3206	protein involved in exopolysaccharide biosynthesis
ACPOL_RS19995	COG0489	protein tyrosine kinase activity
ACPOL_RS20005	COG0438	transferase activity, transferring glycosyl groups
ACPOL_RS20065	COG2095	MarC family integral membrane protein
ACPOL_RS20100	COG1309	transcriptional regulator
ACPOL_RS20105	COG2814	Major facilitator Superfamily
ACPOL_RS20115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACPOL_RS20115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACPOL_RS20120	COG0552	protein localization to endoplasmic reticulum
ACPOL_RS20130	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACPOL_RS20135	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ACPOL_RS20145	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACPOL_RS20155	COG1597	lipid kinase activity
ACPOL_RS20210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACPOL_RS20215	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACPOL_RS20220	COG1187	pseudouridine synthase activity
ACPOL_RS20225	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ACPOL_RS20230	COG0306	phosphate transporter
ACPOL_RS20275	COG0758	DNA mediated transformation
ACPOL_RS20280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ACPOL_RS20300	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ACPOL_RS20325	COG0583	DNA-binding transcription factor activity
ACPOL_RS20340	COG2080	2 iron, 2 sulfur cluster binding
ACPOL_RS20345	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ACPOL_RS20350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACPOL_RS20370	COG1733	regulation of RNA biosynthetic process
ACPOL_RS20375	COG0702	epimerase
ACPOL_RS20390	COG3852	Histidine kinase
ACPOL_RS20400	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS20405	COG1309	transcriptional regulator
ACPOL_RS20420	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS20430	COG0300	oxidoreductase activity
ACPOL_RS20435	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS20440	COG2207	Transcriptional regulator
ACPOL_RS20450	COG0604	alcohol dehydrogenase
ACPOL_RS20480	COG1902	pentaerythritol trinitrate reductase activity
ACPOL_RS20485	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS20490	COG1902	pentaerythritol trinitrate reductase activity
ACPOL_RS20500	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
ACPOL_RS20520	COG4191	Histidine kinase
ACPOL_RS20520	COG0784	Response regulator, receiver
ACPOL_RS20540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACPOL_RS20545	COG1127	ABC transporter
ACPOL_RS20680	COG0629	single-stranded DNA binding
ACPOL_RS20690	COG4962	Type ii secretion system protein e
ACPOL_RS20755	COG4221	oxidoreductase activity
ACPOL_RS20775	COG0582	viral genome integration into host DNA
ACPOL_RS20785	COG0583	DNA-binding transcription factor activity
ACPOL_RS20790	COG2197	response regulator
ACPOL_RS20795	COG4585	Histidine kinase
ACPOL_RS20815	COG4221	oxidoreductase activity
ACPOL_RS20820	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS20830	COG3548	integral membrane protein
ACPOL_RS20850	COG2814	Major facilitator Superfamily
ACPOL_RS20865	COG2226	methyltransferase
ACPOL_RS20930	COG3345	alpha-galactosidase
ACPOL_RS20940	COG2207	Transcriptional regulator
ACPOL_RS20945	COG1082	Xylose isomerase domain protein TIM barrel
ACPOL_RS20960	COG2084	Dehydrogenase
ACPOL_RS20980	COG3537	Alpha-1,2-mannosidase
ACPOL_RS21020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACPOL_RS21120	COG3537	Alpha-1,2-mannosidase
ACPOL_RS21130	COG1733	regulation of RNA biosynthetic process
ACPOL_RS21175	COG1064	alcohol dehydrogenase
ACPOL_RS21200	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACPOL_RS21210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACPOL_RS21220	COG3345	alpha-galactosidase
ACPOL_RS21230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACPOL_RS21250	COG4585	Histidine kinase
ACPOL_RS21305	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
ACPOL_RS21350	COG4962	Type ii secretion system protein e
ACPOL_RS21425	COG4644	lycopene metabolic process
ACPOL_RS21440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACPOL_RS21445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACPOL_RS21450	COG1120	ATPase activity
ACPOL_RS21470	COG1280	lysine exporter protein (LysE YggA)
ACPOL_RS21545	COG1309	transcriptional regulator
ACPOL_RS21600	COG0306	phosphate transporter
ACPOL_RS21610	COG3237	CsbD-like
ACPOL_RS21690	COG1335	isochorismatase
ACPOL_RS21760	COG1921	L-seryl-tRNASec selenium transferase activity
ACPOL_RS21765	COG0709	Synthesizes selenophosphate from selenide and ATP
ACPOL_RS21800	COG0596	Alpha beta hydrolase
ACPOL_RS21810	COG0753	catalase activity
ACPOL_RS21845	COG3547	Transposase (IS116 IS110 IS902 family)
ACPOL_RS21850	COG2801	Transposase and inactivated derivatives
ACPOL_RS21860	COG4191	Histidine kinase
ACPOL_RS21865	COG0515	serine threonine protein kinase
ACPOL_RS21865	COG2815	serine threonine protein kinase
ACPOL_RS21880	COG0584	glycerophosphoryl diester phosphodiesterase
ACPOL_RS21895	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ACPOL_RS21925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACPOL_RS21930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACPOL_RS21930	COG2169	Transcriptional regulator
ACPOL_RS21970	COG3420	alginic acid biosynthetic process
ACPOL_RS21985	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS21990	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS21995	COG2267	carboxylic ester hydrolase activity
ACPOL_RS22040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACPOL_RS22055	COG3391	amine dehydrogenase activity
ACPOL_RS22060	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ACPOL_RS22075	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACPOL_RS22095	COG0322	excinuclease ABC activity
ACPOL_RS22100	COG0312	modulator of DNA gyrase
ACPOL_RS22115	COG3619	membrane
ACPOL_RS22120	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACPOL_RS22125	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ACPOL_RS22165	COG0673	inositol 2-dehydrogenase activity
ACPOL_RS22170	COG0517	IMP dehydrogenase activity
ACPOL_RS22170	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ACPOL_RS22195	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ACPOL_RS22215	COG1846	Transcriptional regulator
ACPOL_RS22215	COG1940	carbohydrate kinase activity
ACPOL_RS22220	COG3250	beta-galactosidase activity
ACPOL_RS22225	COG0531	amino acid
ACPOL_RS22240	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ACPOL_RS22255	COG1160	GTP binding
ACPOL_RS22265	COG1199	ATP-dependent helicase activity
ACPOL_RS22275	COG0450	alkyl hydroperoxide reductase
ACPOL_RS22290	COG1506	peptidase
ACPOL_RS22290	COG0823	Involved in the tonB-independent uptake of proteins
ACPOL_RS22290	COG4946	Tricorn protease homolog
ACPOL_RS22295	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACPOL_RS22300	COG0049	tRNA binding
ACPOL_RS22305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACPOL_RS22310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACPOL_RS22315	COG0051	transcription antitermination factor activity, RNA binding
ACPOL_RS22320	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACPOL_RS22325	COG0088	Forms part of the polypeptide exit tunnel
ACPOL_RS22330	COG0089	rRNA binding
ACPOL_RS22335	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACPOL_RS22340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACPOL_RS22345	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACPOL_RS22350	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACPOL_RS22355	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACPOL_RS22360	COG0255	Belongs to the universal ribosomal protein uL29 family
ACPOL_RS22365	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACPOL_RS22370	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACPOL_RS22375	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ACPOL_RS22380	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACPOL_RS22385	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACPOL_RS22390	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACPOL_RS22395	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACPOL_RS22400	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACPOL_RS22405	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACPOL_RS22410	COG1841	ribosomal large subunit assembly
ACPOL_RS22415	COG0200	Binds to the 23S rRNA
ACPOL_RS22420	COG0201	protein transport
ACPOL_RS22425	COG0563	adenylate kinase activity
ACPOL_RS22435	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACPOL_RS22440	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ACPOL_RS22445	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACPOL_RS22450	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ACPOL_RS22460	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACPOL_RS22465	COG0202	RNA polymerase activity
ACPOL_RS22470	COG0203	ribosomal protein L17
ACPOL_RS22475	COG2770	Histidine kinase
ACPOL_RS22475	COG2208	phosphoserine phosphatase activity
ACPOL_RS22485	COG0517	IMP dehydrogenase activity
ACPOL_RS22485	COG0516	GMP reductase activity
ACPOL_RS22490	COG0779	Required for maturation of 30S ribosomal subunits
ACPOL_RS22495	COG0195	Participates in both transcription termination and antitermination
ACPOL_RS22500	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACPOL_RS22510	COG1136	(ABC) transporter
ACPOL_RS22510	COG0577	efflux transmembrane transporter activity
ACPOL_RS22515	COG0577	efflux transmembrane transporter activity
ACPOL_RS22515	COG1136	(ABC) transporter
ACPOL_RS22525	COG1136	(ABC) transporter
ACPOL_RS22535	COG2204	response regulator
ACPOL_RS22540	COG4191	Histidine kinase
ACPOL_RS22570	COG0823	Involved in the tonB-independent uptake of proteins
ACPOL_RS22580	COG2022	thiamine diphosphate biosynthetic process
ACPOL_RS22585	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ACPOL_RS22600	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACPOL_RS22605	COG0297	glycogen (starch) synthase activity
ACPOL_RS22620	COG0531	amino acid
ACPOL_RS22635	COG0673	inositol 2-dehydrogenase activity
ACPOL_RS22640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACPOL_RS22655	COG1136	(ABC) transporter
ACPOL_RS22655	COG0577	efflux transmembrane transporter activity
ACPOL_RS22670	COG2895	sulfate adenylyltransferase (ATP) activity
ACPOL_RS22675	COG0175	sulfate reduction
ACPOL_RS22690	COG0346	lactoylglutathione lyase activity
ACPOL_RS22695	COG1012	belongs to the aldehyde dehydrogenase family
ACPOL_RS22705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACPOL_RS22715	COG4302	ethanolamine ammonia-lyase activity
ACPOL_RS22720	COG4303	Ethanolamine ammonia lyase large subunit
ACPOL_RS22730	COG1131	(ABC) transporter
ACPOL_RS22770	COG0745	RESPONSE REGULATOR receiver
ACPOL_RS22775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACPOL_RS22800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACPOL_RS22820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACPOL_RS22825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACPOL_RS22840	COG0305	Participates in initiation and elongation during chromosome replication
ACPOL_RS22860	COG0445	tRNA wobble uridine modification
ACPOL_RS22865	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ACPOL_RS22870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACPOL_RS22875	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ACPOL_RS22885	COG0072	phenylalanine-tRNA ligase activity
ACPOL_RS22895	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACPOL_RS22950	COG2875	Belongs to the precorrin methyltransferase family
ACPOL_RS23000	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACPOL_RS23005	COG0335	large ribosomal subunit rRNA binding
ACPOL_RS23010	COG0336	Belongs to the RNA methyltransferase TrmD family
ACPOL_RS23015	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ACPOL_RS23020	COG1837	Belongs to the UPF0109 family
ACPOL_RS23025	COG0228	four-way junction DNA binding
ACPOL_RS23030	COG0339	signal peptide processing
ACPOL_RS23045	COG2382	esterase
ACPOL_RS23060	COG0493	'glutamate synthase
ACPOL_RS23060	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACPOL_RS23070	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACPOL_RS23075	COG1953	Uracil, thiamine, allantoin
ACPOL_RS23080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACPOL_RS23145	COG0366	Alpha amylase catalytic
ACPOL_RS23150	COG0248	Ppx GppA phosphatase
ACPOL_RS23185	COG1566	PFAM secretion protein HlyD family protein
ACPOL_RS23190	COG0783	Belongs to the Dps family
ACPOL_RS23195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACPOL_RS23205	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACPOL_RS23220	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACPOL_RS23225	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ACPOL_RS23230	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ACPOL_RS23245	COG1253	flavin adenine dinucleotide binding
ACPOL_RS23250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACPOL_RS23295	COG2885	chlorophyll binding
ACPOL_RS23300	COG0823	Involved in the tonB-independent uptake of proteins
ACPOL_RS23345	COG1960	acyl-CoA dehydrogenase activity
ACPOL_RS23350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACPOL_RS23355	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ACPOL_RS23360	COG1492	cobalamin metabolic process
ACPOL_RS23365	COG0778	Nitroreductase
ACPOL_RS23385	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ACPOL_RS23390	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ACPOL_RS23420	COG1349	DNA-binding transcription factor activity
ACPOL_RS23425	COG0494	nUDIX hydrolase
ACPOL_RS23435	COG4948	Mandelate Racemase Muconate Lactonizing
ACPOL_RS23455	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ACPOL_RS23460	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS23460	COG3347	Dehydrogenase
ACPOL_RS23465	COG1070	Carbohydrate kinase
ACPOL_RS23495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACPOL_RS23510	COG0101	tRNA pseudouridine synthase activity
ACPOL_RS23520	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACPOL_RS23525	COG1956	GAF domain-containing protein
ACPOL_RS23530	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ACPOL_RS23535	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ACPOL_RS23550	COG3548	integral membrane protein
ACPOL_RS23595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACPOL_RS23600	COG3254	rhamnose metabolic process
ACPOL_RS23605	COG1904	glucuronate isomerase
ACPOL_RS23620	COG0346	lactoylglutathione lyase activity
ACPOL_RS23650	COG1366	Belongs to the anti-sigma-factor antagonist family
ACPOL_RS23655	COG1366	Belongs to the anti-sigma-factor antagonist family
ACPOL_RS23675	COG4191	Histidine kinase
ACPOL_RS23690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPOL_RS23700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACPOL_RS23730	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACPOL_RS23745	COG1704	LemA family
ACPOL_RS23755	COG1959	2 iron, 2 sulfur cluster binding
ACPOL_RS23760	COG1692	metallophosphoesterase
ACPOL_RS23770	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACPOL_RS23780	COG1228	amidohydrolase
ACPOL_RS23795	COG0356	it plays a direct role in the translocation of protons across the membrane
ACPOL_RS23800	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACPOL_RS23845	COG0138	bifunctional purine biosynthesis protein purh
ACPOL_RS23895	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ACPOL_RS23900	COG2204	response regulator
ACPOL_RS23905	COG0501	Belongs to the peptidase M48B family
ACPOL_RS23910	COG1136	(ABC) transporter
ACPOL_RS23970	COG2197	response regulator
ACPOL_RS23980	COG4566	intracellular signal transduction
ACPOL_RS23985	COG4191	Histidine kinase
ACPOL_RS24025	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACPOL_RS24025	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ACPOL_RS24035	COG1902	pentaerythritol trinitrate reductase activity
ACPOL_RS24045	COG0656	L-ascorbic acid biosynthetic process
ACPOL_RS24065	COG2084	Dehydrogenase
ACPOL_RS24090	COG4566	intracellular signal transduction
ACPOL_RS24095	COG2318	DinB family
ACPOL_RS24105	COG2172	sigma factor antagonist activity
ACPOL_RS24115	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACPOL_RS24120	COG1127	ABC transporter
ACPOL_RS24140	COG5002	protein histidine kinase activity
ACPOL_RS24140	COG2205	protein histidine kinase activity
ACPOL_RS24140	COG0784	Response regulator, receiver
ACPOL_RS24160	COG0463	Glycosyl transferase, family 2
ACPOL_RS24170	COG1620	l-lactate permease
ACPOL_RS24175	COG0657	acetylesterase activity
ACPOL_RS24175	COG2755	lipolytic protein G-D-S-L family
ACPOL_RS24180	COG2205	protein histidine kinase activity
ACPOL_RS24185	COG2205	protein histidine kinase activity
ACPOL_RS24210	COG0745	RESPONSE REGULATOR receiver
ACPOL_RS24250	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ACPOL_RS24255	COG0698	ribose 5-phosphate isomerase
ACPOL_RS24270	COG0363	glucosamine-6-phosphate deaminase activity
ACPOL_RS24275	COG0837	glucose binding
ACPOL_RS24290	COG0069	glutamate synthase activity
ACPOL_RS24290	COG0070	glutamate synthase
ACPOL_RS24290	COG0067	glutamate synthase
ACPOL_RS24305	COG3546	catalase activity
ACPOL_RS24345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACPOL_RS24350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACPOL_RS24365	COG0514	ATP-dependent DNA helicase (RecQ)
ACPOL_RS24370	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS24395	COG0284	orotidine-5'-phosphate decarboxylase activity
ACPOL_RS24400	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACPOL_RS24405	COG0351	phosphomethylpyrimidine kinase
ACPOL_RS24430	COG1131	(ABC) transporter
ACPOL_RS24445	COG1335	isochorismatase
ACPOL_RS24460	COG1349	DNA-binding transcription factor activity
ACPOL_RS24465	COG3142	Participates in the control of copper homeostasis
ACPOL_RS24475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ACPOL_RS24485	COG0295	cytidine deaminase activity
ACPOL_RS24495	COG0037	tRNA processing
ACPOL_RS24510	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACPOL_RS24515	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACPOL_RS24525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACPOL_RS24550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACPOL_RS24570	COG0442	prolyl-tRNA aminoacylation
ACPOL_RS24580	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACPOL_RS24585	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ACPOL_RS24590	COG0693	protein deglycase activity
ACPOL_RS24600	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACPOL_RS24610	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACPOL_RS24630	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ACPOL_RS24640	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ACPOL_RS24645	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ACPOL_RS24655	COG0535	radical SAM domain protein
ACPOL_RS24665	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
ACPOL_RS24670	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ACPOL_RS24695	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACPOL_RS24705	COG0617	tRNA 3'-terminal CCA addition
ACPOL_RS24760	COG1116	anion transmembrane transporter activity
ACPOL_RS24770	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ACPOL_RS24775	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ACPOL_RS24815	COG3956	TIGRFAM MazG family protein
ACPOL_RS24825	COG4948	Mandelate Racemase Muconate Lactonizing
ACPOL_RS24895	COG1819	glycosyl
ACPOL_RS24910	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACPOL_RS24915	COG0795	lipopolysaccharide-transporting ATPase activity
ACPOL_RS24920	COG1937	Protein conserved in bacteria
ACPOL_RS24925	COG2217	Heavy metal translocating P-type atpase
ACPOL_RS24930	COG2608	mercury ion transmembrane transporter activity
ACPOL_RS24935	COG0745	RESPONSE REGULATOR receiver
ACPOL_RS24940	COG5002	protein histidine kinase activity
ACPOL_RS24945	COG0598	Magnesium transport protein CorA
ACPOL_RS24950	COG1842	Phage shock protein A
ACPOL_RS24955	COG2268	Band 7 protein
ACPOL_RS24990	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ACPOL_RS24995	COG0823	Involved in the tonB-independent uptake of proteins
ACPOL_RS24995	COG1506	peptidase
ACPOL_RS25005	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACPOL_RS25020	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACPOL_RS25025	COG0612	Peptidase, M16
ACPOL_RS25070	COG2124	cytochrome p450
ACPOL_RS25085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACPOL_RS25095	COG0745	RESPONSE REGULATOR receiver
ACPOL_RS25115	COG2124	cytochrome p450
ACPOL_RS25120	COG3474	cytochrome
ACPOL_RS25150	COG4644	lycopene metabolic process
ACPOL_RS25310	COG0346	lactoylglutathione lyase activity
ACPOL_RS25315	COG1214	PFAM Peptidase M22, glycoprotease
ACPOL_RS25320	COG0456	acetyltransferase
ACPOL_RS25330	COG0688	phosphatidylethanolamine metabolic process
ACPOL_RS25335	COG1183	phosphatidylcholine synthase activity
ACPOL_RS25350	COG0457	Tetratricopeptide repeat
ACPOL_RS25355	COG1360	Flagellar Motor Protein
ACPOL_RS25360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ACPOL_RS25370	COG3510	cephalosporin hydroxylase
ACPOL_RS25395	COG1132	(ABC) transporter
ACPOL_RS25415	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ACPOL_RS25430	COG0165	Argininosuccinate lyase
ACPOL_RS25435	COG0137	argininosuccinate synthase activity
ACPOL_RS25440	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACPOL_RS25445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACPOL_RS25450	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACPOL_RS25455	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACPOL_RS25460	COG1438	arginine binding
ACPOL_RS25465	COG0439	Biotin carboxylase
ACPOL_RS25470	COG0511	ligase activity, forming carbon-carbon bonds
ACPOL_RS25475	COG0006	proline dipeptidase activity
ACPOL_RS25485	COG0205	6-phosphofructokinase activity
ACPOL_RS25490	COG1022	Amp-dependent synthetase and ligase
ACPOL_RS25495	COG0352	thiamine-phosphate diphosphorylase activity
ACPOL_RS25500	COG1113	amino acid transport
ACPOL_RS25505	COG0531	amino acid
ACPOL_RS25520	COG1215	transferase activity, transferring glycosyl groups
ACPOL_RS25535	COG0302	gtp cyclohydrolase
ACPOL_RS25540	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACPOL_RS25550	COG4181	ATPase activity
ACPOL_RS25555	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ACPOL_RS25565	COG0277	FAD linked oxidase domain protein
ACPOL_RS25570	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ACPOL_RS25575	COG0459	protein refolding
ACPOL_RS25590	COG1606	tRNA processing
ACPOL_RS25595	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
ACPOL_RS25600	COG1691	(AIR) carboxylase
ACPOL_RS25620	COG0656	L-ascorbic acid biosynthetic process
ACPOL_RS25625	COG0667	Aldo Keto reductase
ACPOL_RS25630	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS25635	COG2271	Major facilitator Superfamily
ACPOL_RS25665	COG3537	Alpha-1,2-mannosidase
ACPOL_RS25670	COG1233	COG1233 Phytoene dehydrogenase and related
ACPOL_RS25675	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACPOL_RS25680	COG0156	8-amino-7-oxononanoate synthase activity
ACPOL_RS25685	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ACPOL_RS25690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACPOL_RS25695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACPOL_RS25715	COG0534	Mate efflux family protein
ACPOL_RS25730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACPOL_RS25745	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ACPOL_RS25750	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ACPOL_RS25760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACPOL_RS25785	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ACPOL_RS25785	COG3264	Mechanosensitive ion channel
ACPOL_RS25790	COG0438	transferase activity, transferring glycosyl groups
ACPOL_RS25795	COG0463	Glycosyl transferase, family 2
ACPOL_RS25800	COG0438	transferase activity, transferring glycosyl groups
ACPOL_RS25815	COG1216	Glycosyl transferase, family 2
ACPOL_RS25820	COG0489	protein tyrosine kinase activity
ACPOL_RS25820	COG3206	protein involved in exopolysaccharide biosynthesis
ACPOL_RS25835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACPOL_RS25845	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ACPOL_RS25850	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ACPOL_RS25865	COG0366	Alpha amylase catalytic
ACPOL_RS25870	COG0366	Alpha amylase catalytic
ACPOL_RS25875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACPOL_RS25895	COG3940	Belongs to the glycosyl hydrolase 43 family
ACPOL_RS25920	COG3940	Belongs to the glycosyl hydrolase 43 family
ACPOL_RS25935	COG2723	6-phospho-beta-galactosidase activity
ACPOL_RS25955	COG0577	efflux transmembrane transporter activity
ACPOL_RS25955	COG1136	(ABC) transporter
ACPOL_RS25970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACPOL_RS26015	COG0316	Belongs to the HesB IscA family
ACPOL_RS26030	COG1053	succinate dehydrogenase
ACPOL_RS26040	COG0297	glycogen (starch) synthase activity
ACPOL_RS26045	COG2223	nitrite transmembrane transporter activity
ACPOL_RS26055	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ACPOL_RS26070	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACPOL_RS26075	COG1085	galactose-1-phosphate uridylyltransferase
ACPOL_RS26085	COG0463	Glycosyl transferase, family 2
ACPOL_RS26095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACPOL_RS26100	COG1132	(ABC) transporter
ACPOL_RS26105	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACPOL_RS26125	COG1136	(ABC) transporter
ACPOL_RS26125	COG0577	efflux transmembrane transporter activity
ACPOL_RS26130	COG0577	efflux transmembrane transporter activity
ACPOL_RS26130	COG1136	(ABC) transporter
ACPOL_RS26160	COG1408	metallophosphoesterase
ACPOL_RS26175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACPOL_RS26205	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS26210	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS26220	COG0577	efflux transmembrane transporter activity
ACPOL_RS26220	COG1136	(ABC) transporter
ACPOL_RS26235	COG1335	isochorismatase
ACPOL_RS26245	COG1595	DNA-templated transcription, initiation
ACPOL_RS26280	COG0745	RESPONSE REGULATOR receiver
ACPOL_RS26315	COG1845	cytochrome c oxidase, subunit III
ACPOL_RS26320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACPOL_RS26325	COG2010	Cytochrome c
ACPOL_RS26325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ACPOL_RS26335	COG4952	isomerase
ACPOL_RS26340	COG0673	inositol 2-dehydrogenase activity
ACPOL_RS26360	COG0586	Pfam SNARE associated Golgi protein
ACPOL_RS26365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ACPOL_RS26375	COG1587	Uroporphyrinogen-III synthase
ACPOL_RS26380	COG0181	hydroxymethylbilane synthase activity
ACPOL_RS26385	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ACPOL_RS26400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ACPOL_RS26405	COG1472	Belongs to the glycosyl hydrolase 3 family
ACPOL_RS26415	COG0747	negative chemotaxis
ACPOL_RS26420	COG2815	serine threonine protein kinase
ACPOL_RS26420	COG0515	serine threonine protein kinase
ACPOL_RS26435	COG1733	regulation of RNA biosynthetic process
ACPOL_RS26490	COG1136	(ABC) transporter
ACPOL_RS26500	COG0542	response to heat
ACPOL_RS26520	COG0356	it plays a direct role in the translocation of protons across the membrane
ACPOL_RS26525	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACPOL_RS26530	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACPOL_RS26535	COG0649	NAD binding
ACPOL_RS26575	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACPOL_RS26585	COG0713	ATP synthesis coupled electron transport
ACPOL_RS26600	COG1007	ATP synthesis coupled electron transport
ACPOL_RS26605	COG4941	Belongs to the sigma-70 factor family
ACPOL_RS26650	COG0577	efflux transmembrane transporter activity
ACPOL_RS26650	COG1136	(ABC) transporter
ACPOL_RS26655	COG0443	Heat shock 70 kDa protein
ACPOL_RS26680	COG0667	Aldo Keto reductase
ACPOL_RS26685	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ACPOL_RS26700	COG3383	formate dehydrogenase (NAD+) activity
ACPOL_RS26705	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACPOL_RS26710	COG3259	Nickel-dependent hydrogenase
ACPOL_RS26720	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ACPOL_RS26725	COG0167	dihydroorotate dehydrogenase activity
ACPOL_RS26730	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACPOL_RS26730	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACPOL_RS26730	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACPOL_RS26730	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ACPOL_RS26735	COG3795	YCII-related domain
ACPOL_RS26745	COG3795	YCII-related domain
ACPOL_RS26750	COG4941	Belongs to the sigma-70 factor family
ACPOL_RS26785	COG2723	6-phospho-beta-galactosidase activity
ACPOL_RS26790	COG0751	glycine-tRNA ligase activity
ACPOL_RS26795	COG0752	glycyl-tRNA synthetase alpha subunit
ACPOL_RS26810	COG1381	Involved in DNA repair and RecF pathway recombination
ACPOL_RS26825	COG0483	inositol monophosphate 1-phosphatase activity
ACPOL_RS26835	COG1543	Belongs to the glycosyl hydrolase 57 family
ACPOL_RS26850	COG1960	acyl-CoA dehydrogenase activity
ACPOL_RS26865	COG0183	Belongs to the thiolase family
ACPOL_RS26870	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACPOL_RS26870	COG1024	Enoyl-CoA hydratase
ACPOL_RS26875	COG0612	Peptidase, M16
ACPOL_RS26880	COG0612	Peptidase, M16
ACPOL_RS26885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACPOL_RS26890	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACPOL_RS26910	COG0556	nucleotide-excision repair
ACPOL_RS26915	COG2205	protein histidine kinase activity
ACPOL_RS26940	COG0436	Aminotransferase
ACPOL_RS26955	COG0673	inositol 2-dehydrogenase activity
ACPOL_RS26960	COG1366	Belongs to the anti-sigma-factor antagonist family
ACPOL_RS26975	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ACPOL_RS26980	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ACPOL_RS26985	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ACPOL_RS27010	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACPOL_RS27015	COG1605	Chorismate mutase
ACPOL_RS27015	COG0077	Prephenate dehydratase
ACPOL_RS27025	COG3237	CsbD-like
ACPOL_RS27045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACPOL_RS27055	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ACPOL_RS27070	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACPOL_RS27080	COG0109	protoheme IX farnesyltransferase activity
ACPOL_RS27095	COG2322	membrane
ACPOL_RS27110	COG1309	transcriptional regulator
ACPOL_RS27155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACPOL_RS27160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACPOL_RS27170	COG0460	homoserine dehydrogenase
ACPOL_RS27195	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACPOL_RS27200	COG0242	peptide deformylase activity
ACPOL_RS27210	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACPOL_RS27220	COG0745	RESPONSE REGULATOR receiver
ACPOL_RS27225	COG5002	protein histidine kinase activity
ACPOL_RS27285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACPOL_RS27295	COG2124	cytochrome p450
ACPOL_RS27330	COG2814	Major facilitator Superfamily
ACPOL_RS27335	COG1331	Highly conserved protein containing a thioredoxin domain
ACPOL_RS27365	COG4456	Virulence-associated protein
ACPOL_RS27375	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACPOL_RS27380	COG2009	succinate dehydrogenase
ACPOL_RS27385	COG1053	succinate dehydrogenase
ACPOL_RS27390	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACPOL_RS27415	COG0039	L-malate dehydrogenase activity
ACPOL_RS27420	COG0538	isocitrate dehydrogenase activity
ACPOL_RS27425	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ACPOL_RS27435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACPOL_RS27460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACPOL_RS27465	COG0662	Cupin 2, conserved barrel domain protein
ACPOL_RS27465	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ACPOL_RS27470	COG1482	cell wall glycoprotein biosynthetic process
ACPOL_RS27480	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ACPOL_RS27485	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ACPOL_RS27525	COG3961	Belongs to the TPP enzyme family
ACPOL_RS27585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACPOL_RS27660	COG3411	Ferredoxin
ACPOL_RS27670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ACPOL_RS27710	COG1301	dicarboxylic acid transport
ACPOL_RS27720	COG0166	Belongs to the GPI family
ACPOL_RS27725	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ACPOL_RS27740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ACPOL_RS27755	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ACPOL_RS27765	COG0525	valine-tRNA ligase activity
ACPOL_RS27780	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ACPOL_RS27790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACPOL_RS27795	COG2333	competence protein COMEC
ACPOL_RS27795	COG0658	competence protein
ACPOL_RS27820	COG1663	tetraacyldisaccharide 4'-kinase activity
ACPOL_RS27825	COG1519	Transferase
ACPOL_RS27835	COG0602	queuosine metabolic process
ACPOL_RS27840	COG0720	synthase
ACPOL_RS27855	COG1595	DNA-templated transcription, initiation
ACPOL_RS27865	COG0477	Major facilitator Superfamily
ACPOL_RS27880	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACPOL_RS27885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACPOL_RS27890	COG1024	Enoyl-CoA hydratase
ACPOL_RS27900	COG0247	lactate metabolic process
ACPOL_RS27900	COG0277	FAD linked oxidase domain protein
ACPOL_RS27915	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACPOL_RS27920	COG0107	imidazoleglycerol-phosphate synthase activity
ACPOL_RS27930	COG0131	Imidazoleglycerol-phosphate dehydratase
ACPOL_RS27935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACPOL_RS27940	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACPOL_RS27945	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ACPOL_RS27950	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACPOL_RS27960	COG0792	nuclease activity
ACPOL_RS27965	COG2975	iron-sulfur cluster assembly
ACPOL_RS27975	COG0443	Heat shock 70 kDa protein
ACPOL_RS27980	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ACPOL_RS27985	COG0316	Belongs to the HesB IscA family
ACPOL_RS27995	COG1104	cysteine desulfurase activity
ACPOL_RS28000	COG1959	2 iron, 2 sulfur cluster binding
ACPOL_RS28005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACPOL_RS28020	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ACPOL_RS28020	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACPOL_RS28025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACPOL_RS28030	COG4974	Belongs to the 'phage' integrase family
ACPOL_RS28045	COG1196	nuclear chromosome segregation
ACPOL_RS28045	COG0741	lytic transglycosylase activity
ACPOL_RS28045	COG0739	heme binding
ACPOL_RS28070	COG0477	Major facilitator Superfamily
ACPOL_RS28210	COG0629	single-stranded DNA binding
ACPOL_RS28230	COG2267	carboxylic ester hydrolase activity
ACPOL_RS28340	COG0328	RNA-DNA hybrid ribonuclease activity
ACPOL_RS28350	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ACPOL_RS28355	COG1733	regulation of RNA biosynthetic process
ACPOL_RS28365	COG0412	Dienelactone hydrolase
ACPOL_RS28370	COG4221	oxidoreductase activity
ACPOL_RS28465	COG0667	Aldo Keto reductase
ACPOL_RS28495	COG0708	Exodeoxyribonuclease III
ACPOL_RS28510	COG0778	Nitroreductase
ACPOL_RS28535	COG1228	amidohydrolase
ACPOL_RS28570	COG0402	S-adenosylhomocysteine deaminase activity
ACPOL_RS28590	COG2207	Transcriptional regulator
ACPOL_RS28595	COG4221	oxidoreductase activity
ACPOL_RS28620	COG0066	3-isopropylmalate dehydratase activity
ACPOL_RS28625	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ACPOL_RS28630	COG0473	3-isopropylmalate dehydrogenase activity
ACPOL_RS28645	COG2311	Membrane
ACPOL_RS28675	COG0384	phenazine biosynthesis protein PhzF
ACPOL_RS28700	COG1063	alcohol dehydrogenase
ACPOL_RS28720	COG0745	RESPONSE REGULATOR receiver
ACPOL_RS28760	COG0367	asparagine synthase
ACPOL_RS28770	COG1505	serine-type exopeptidase activity
ACPOL_RS28790	COG1132	(ABC) transporter
ACPOL_RS28900	COG3436	PFAM IS66 Orf2 family protein
ACPOL_RS28910	COG0582	viral genome integration into host DNA
ACPOL_RS28915	COG0582	viral genome integration into host DNA
ACPOL_RS28920	COG0582	viral genome integration into host DNA
ACPOL_RS28930	COG3344	reverse transcriptase
ACPOL_RS28950	COG1595	DNA-templated transcription, initiation
ACPOL_RS28970	COG3415	Transposase
ACPOL_RS28970	COG2801	Transposase and inactivated derivatives
ACPOL_RS28985	COG0629	single-stranded DNA binding
ACPOL_RS29050	COG3118	belongs to the thioredoxin family
ACPOL_RS29060	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACPOL_RS29065	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ACPOL_RS29070	COG2080	2 iron, 2 sulfur cluster binding
ACPOL_RS29110	COG0582	viral genome integration into host DNA
ACPOL_RS29115	COG4804	nuclease activity
ACPOL_RS29135	COG3344	reverse transcriptase
ACPOL_RS29225	COG2226	methyltransferase
ACPOL_RS29230	COG0493	'glutamate synthase
ACPOL_RS29270	COG3708	Transcriptional regulator
ACPOL_RS29270	COG2207	Transcriptional regulator
ACPOL_RS29290	COG3850	Histidine kinase
ACPOL_RS29310	COG0531	amino acid
ACPOL_RS29350	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ACPOL_RS29365	COG1228	amidohydrolase
ACPOL_RS29400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACPOL_RS29415	COG2207	Transcriptional regulator
ACPOL_RS29435	COG0531	amino acid
ACPOL_RS29475	COG2311	Membrane
ACPOL_RS29480	COG2311	Membrane
ACPOL_RS29545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACPOL_RS29555	COG3436	PFAM IS66 Orf2 family protein
ACPOL_RS29570	COG5002	protein histidine kinase activity
ACPOL_RS29575	COG0745	RESPONSE REGULATOR receiver
ACPOL_RS29615	COG0667	Aldo Keto reductase
ACPOL_RS29720	COG4974	Belongs to the 'phage' integrase family
ACPOL_RS29750	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS29755	COG1309	transcriptional regulator
ACPOL_RS29770	COG0154	amidase activity
ACPOL_RS29775	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS29800	COG1063	alcohol dehydrogenase
ACPOL_RS29810	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS29840	COG1275	C4-dicarboxylate transporter malic acid transport protein
ACPOL_RS29850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACPOL_RS29855	COG2080	2 iron, 2 sulfur cluster binding
ACPOL_RS29860	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ACPOL_RS29865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACPOL_RS29930	COG0604	alcohol dehydrogenase
ACPOL_RS29935	COG1063	alcohol dehydrogenase
ACPOL_RS29960	COG2433	Pfam Transposase IS66
ACPOL_RS29970	COG3548	integral membrane protein
ACPOL_RS29980	COG1275	C4-dicarboxylate transporter malic acid transport protein
ACPOL_RS30005	COG1902	pentaerythritol trinitrate reductase activity
ACPOL_RS30060	COG2207	Transcriptional regulator
ACPOL_RS30060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACPOL_RS30070	COG4566	intracellular signal transduction
ACPOL_RS30090	COG1609	Transcriptional regulator
ACPOL_RS30125	COG1501	Belongs to the glycosyl hydrolase 31 family
ACPOL_RS30130	COG1501	Belongs to the glycosyl hydrolase 31 family
ACPOL_RS30165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACPOL_RS30170	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ACPOL_RS30195	COG3186	Phenylalanine-4-hydroxylase
ACPOL_RS30205	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ACPOL_RS30210	COG0667	Aldo Keto reductase
ACPOL_RS30225	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACPOL_RS30235	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACPOL_RS30235	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACPOL_RS30240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACPOL_RS30250	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ACPOL_RS30265	COG0505	Belongs to the CarA family
ACPOL_RS30290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ACPOL_RS30305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACPOL_RS30325	COG1185	polyribonucleotide nucleotidyltransferase activity
ACPOL_RS30330	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACPOL_RS30350	COG2814	Major facilitator Superfamily
ACPOL_RS30375	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ACPOL_RS30385	COG1970	mechanosensitive ion channel activity
ACPOL_RS30395	COG1942	4-Oxalocrotonate Tautomerase
ACPOL_RS30405	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ACPOL_RS30425	COG0254	rRNA binding
ACPOL_RS30430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACPOL_RS30440	COG3403	YqcI/YcgG family
ACPOL_RS30450	COG3279	Response regulator of the LytR AlgR family
ACPOL_RS30455	COG3275	phosphorelay sensor kinase activity
ACPOL_RS30465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACPOL_RS30470	COG3345	alpha-galactosidase
ACPOL_RS30475	COG0326	Molecular chaperone. Has ATPase activity
ACPOL_RS30715	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ACPOL_RS30865	COG3852	Histidine kinase
ACPOL_RS30905	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ACPOL_RS30960	COG3064	Membrane
ACPOL_RS30975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ACPOL_RS30990	COG1132	(ABC) transporter
ACPOL_RS31150	COG0704	Plays a role in the regulation of phosphate uptake
ACPOL_RS31190	COG4453	Protein conserved in bacteria
ACPOL_RS31195	COG2205	protein histidine kinase activity
ACPOL_RS31205	COG2801	Transposase and inactivated derivatives
ACPOL_RS31210	COG3547	Transposase (IS116 IS110 IS902 family)
ACPOL_RS31220	COG2801	Transposase and inactivated derivatives
ACPOL_RS31240	COG3852	Histidine kinase
ACPOL_RS31280	COG1923	regulation of RNA biosynthetic process
ACPOL_RS31330	COG4804	nuclease activity
ACPOL_RS31425	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ACPOL_RS31575	COG2203	Gaf domain
ACPOL_RS31575	COG2199	diguanylate cyclase activity
ACPOL_RS31615	COG3537	Alpha-1,2-mannosidase
ACPOL_RS31680	COG3706	GGDEF domain
ACPOL_RS31710	COG3345	alpha-galactosidase
ACPOL_RS31800	COG3547	Transposase (IS116 IS110 IS902 family)
ACPOL_RS31845	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ACPOL_RS31855	COG3059	membrane
ACPOL_RS31860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACPOL_RS31890	COG0604	alcohol dehydrogenase
ACPOL_RS31890	COG3321	synthase
ACPOL_RS31895	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS31915	COG0515	serine threonine protein kinase
ACPOL_RS31930	COG1506	peptidase
ACPOL_RS31930	COG0823	Involved in the tonB-independent uptake of proteins
ACPOL_RS31930	COG4946	Tricorn protease homolog
ACPOL_RS32090	COG1940	carbohydrate kinase activity
ACPOL_RS32095	COG2814	Major facilitator Superfamily
ACPOL_RS32100	COG3547	Transposase (IS116 IS110 IS902 family)
ACPOL_RS32135	COG1028	Short-chain dehydrogenase reductase Sdr
ACPOL_RS32190	COG2076	Multidrug Resistance protein
ACPOL_RS32290	COG2267	carboxylic ester hydrolase activity
ACPOL_RS32295	COG1595	DNA-templated transcription, initiation
ACPOL_RS32360	COG4977	sequence-specific DNA binding
ACPOL_RS32380	COG0629	single-stranded DNA binding
ACPOL_RS32400	COG0628	permease
ACPOL_RS32480	COG0628	permease
ACPOL_RS32500	COG0629	single-stranded DNA binding
ACPOL_RS32520	COG4977	sequence-specific DNA binding
ACPOL_RS32610	COG0667	Aldo Keto reductase
ACPOL_RS32620	COG0738	Major facilitator superfamily
ACPOL_RS32625	COG1063	alcohol dehydrogenase
ACPOL_RS32655	COG3547	Transposase (IS116 IS110 IS902 family)
ACPOL_RS32675	COG1475	DNA binding
ACPOL_RS32695	COG1902	pentaerythritol trinitrate reductase activity
ACPOL_RS32705	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
ACPOL_RS32715	COG1902	pentaerythritol trinitrate reductase activity
ACPOL_RS32725	COG0673	inositol 2-dehydrogenase activity
ACPOL_RS32740	COG1902	pentaerythritol trinitrate reductase activity
ACPOL_RS32745	COG2197	response regulator
ACPOL_RS32755	COG0745	RESPONSE REGULATOR receiver
ACPOL_RS32755	COG3292	Two component regulator propeller
ACPOL_RS32755	COG0745	RESPONSE REGULATOR receiver
ACPOL_RS32755	COG2205	protein histidine kinase activity
ACPOL_RS32755	COG3292	Two component regulator propeller
ACPOL_RS32755	COG2205	protein histidine kinase activity
ACPOL_RS32765	COG3547	Transposase (IS116 IS110 IS902 family)
ACPOL_RS32915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ACPOL_RS32940	COG2948	multi-organism process
ACPOL_RS32945	COG2948	multi-organism process
ACPOL_RS32950	COG3504	Conjugal transfer protein
ACPOL_RS32980	COG3451	type IV secretory pathway VirB4
ACPOL_RS32985	COG5268	conjugation
ACPOL_RS32995	COG4962	Type ii secretion system protein e
ACPOL_RS33055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs