locus-tag	class	description
ACP_RS00005	COG1556	Lactate utilization protein
ACP_RS00010	COG1139	Iron-sulfur cluster binding protein
ACP_RS00015	COG0247	lactate metabolic process
ACP_RS00050	COG3537	Alpha-1,2-mannosidase
ACP_RS00060	COG1566	PFAM secretion protein HlyD family protein
ACP_RS00075	COG3534	alpha-L-arabinofuranosidase
ACP_RS00090	COG0583	DNA-binding transcription factor activity
ACP_RS00110	COG1609	Transcriptional regulator
ACP_RS00125	COG2814	Major facilitator Superfamily
ACP_RS00140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACP_RS00155	COG2706	6-phosphogluconolactonase activity
ACP_RS00170	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ACP_RS00180	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ACP_RS00195	COG1349	DNA-binding transcription factor activity
ACP_RS00220	COG2244	polysaccharide biosynthetic process
ACP_RS00255	COG3345	alpha-galactosidase
ACP_RS00290	COG1278	Cold shock
ACP_RS00295	COG0612	Peptidase, M16
ACP_RS00300	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACP_RS00305	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ACP_RS00310	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ACP_RS00335	COG1085	galactose-1-phosphate uridylyltransferase
ACP_RS00340	COG1609	Transcriptional regulator
ACP_RS00375	COG3250	beta-galactosidase activity
ACP_RS00395	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ACP_RS00400	COG0457	Tetratricopeptide repeat
ACP_RS00415	COG2205	protein histidine kinase activity
ACP_RS00420	COG2205	protein histidine kinase activity
ACP_RS00435	COG1606	tRNA processing
ACP_RS00440	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
ACP_RS00445	COG1691	(AIR) carboxylase
ACP_RS00455	COG0538	isocitrate dehydrogenase activity
ACP_RS00460	COG0039	L-malate dehydrogenase activity
ACP_RS00515	COG1053	succinate dehydrogenase
ACP_RS00525	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACP_RS00545	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ACP_RS00555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ACP_RS00570	COG1132	(ABC) transporter
ACP_RS00575	COG0795	lipopolysaccharide-transporting ATPase activity
ACP_RS00580	COG2217	Heavy metal translocating P-type atpase
ACP_RS00585	COG2608	mercury ion transmembrane transporter activity
ACP_RS00605	COG0352	thiamine-phosphate diphosphorylase activity
ACP_RS00610	COG0531	amino acid
ACP_RS00615	COG0531	amino acid
ACP_RS00630	COG0205	6-phosphofructokinase activity
ACP_RS00645	COG0006	proline dipeptidase activity
ACP_RS00650	COG0511	ligase activity, forming carbon-carbon bonds
ACP_RS00655	COG0439	Biotin carboxylase
ACP_RS00665	COG0840	transmembrane signaling receptor activity
ACP_RS00670	COG1487	ribonuclease activity
ACP_RS00675	COG4456	Virulence-associated protein
ACP_RS00685	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACP_RS00690	COG1268	BioY protein
ACP_RS00695	COG1324	tolerance protein
ACP_RS00700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACP_RS00725	COG0412	Dienelactone hydrolase
ACP_RS00735	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACP_RS00740	COG1185	polyribonucleotide nucleotidyltransferase activity
ACP_RS00760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACP_RS00765	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ACP_RS00775	COG0681	Belongs to the peptidase S26 family
ACP_RS00785	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACP_RS00790	COG2208	phosphoserine phosphatase activity
ACP_RS00790	COG2770	Histidine kinase
ACP_RS00795	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ACP_RS00800	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ACP_RS00810	COG2200	EAL domain
ACP_RS00820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACP_RS00845	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ACP_RS00850	COG3956	TIGRFAM MazG family protein
ACP_RS00860	COG4948	Mandelate Racemase Muconate Lactonizing
ACP_RS00875	COG1960	acyl-CoA dehydrogenase activity
ACP_RS00885	COG1127	ABC transporter
ACP_RS00890	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACP_RS00895	COG2204	response regulator
ACP_RS00900	COG5002	protein histidine kinase activity
ACP_RS00930	COG1643	Atp-dependent helicase
ACP_RS00970	COG0673	inositol 2-dehydrogenase activity
ACP_RS00985	COG0129	dihydroxy-acid dehydratase activity
ACP_RS01000	COG0702	epimerase
ACP_RS01005	COG4221	oxidoreductase activity
ACP_RS01010	COG1064	alcohol dehydrogenase
ACP_RS01025	COG0300	oxidoreductase activity
ACP_RS01050	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ACP_RS01060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACP_RS01090	COG0596	Alpha beta hydrolase
ACP_RS01125	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACP_RS01130	COG0083	homoserine kinase activity
ACP_RS01135	COG3118	belongs to the thioredoxin family
ACP_RS01140	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACP_RS01150	COG3604	Transcriptional regulator
ACP_RS01160	COG1558	bacterial-type flagellum-dependent cell motility
ACP_RS01165	COG1677	Flagellar hook-basal body complex protein FliE
ACP_RS01175	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACP_RS01185	COG1157	protein secretion by the type III secretion system
ACP_RS01220	COG1338	Plays a role in the flagellum-specific transport system
ACP_RS01230	COG1684	flagellar biosynthetic protein fliR
ACP_RS01240	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACP_RS01250	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACP_RS01250	COG1776	CheC inhibitor of MCP methylation
ACP_RS01260	COG4786	Flagellar basal body rod
ACP_RS01265	COG4786	Flagellar basal body rod
ACP_RS01275	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ACP_RS01280	COG1706	bacterial-type flagellum-dependent cell motility
ACP_RS01320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACP_RS01325	COG1331	Highly conserved protein containing a thioredoxin domain
ACP_RS01360	COG0534	Mate efflux family protein
ACP_RS01365	COG1959	2 iron, 2 sulfur cluster binding
ACP_RS01370	COG1692	metallophosphoesterase
ACP_RS01375	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACP_RS01395	COG0356	it plays a direct role in the translocation of protons across the membrane
ACP_RS01405	COG1007	ATP synthesis coupled electron transport
ACP_RS01410	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACP_RS01420	COG0713	ATP synthesis coupled electron transport
ACP_RS01430	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACP_RS01455	COG0649	NAD binding
ACP_RS01460	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACP_RS01465	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACP_RS01485	COG0148	phosphopyruvate hydratase activity
ACP_RS01495	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ACP_RS01520	COG1132	(ABC) transporter
ACP_RS01530	COG3265	gluconokinase activity
ACP_RS01535	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ACP_RS01545	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ACP_RS01560	COG1609	Transcriptional regulator
ACP_RS01565	COG0460	homoserine dehydrogenase
ACP_RS01575	COG0667	Aldo Keto reductase
ACP_RS01580	COG3383	formate dehydrogenase (NAD+) activity
ACP_RS01585	COG2427	Protein of unknown function (DUF1641)
ACP_RS01590	COG1609	Transcriptional regulator
ACP_RS01595	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACP_RS01595	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACP_RS01620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACP_RS01625	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACP_RS01625	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACP_RS01630	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACP_RS01670	COG3046	protein related to deoxyribodipyrimidine photolyase
ACP_RS01675	COG0644	oxidoreductase
ACP_RS01695	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ACP_RS01710	COG0488	(ABC) transporter
ACP_RS01715	COG0488	(ABC) transporter
ACP_RS01755	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ACP_RS01765	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ACP_RS01770	COG1119	ATPase activity
ACP_RS02055	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACP_RS02055	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACP_RS02065	COG0436	Aminotransferase
ACP_RS02070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACP_RS02090	COG2205	protein histidine kinase activity
ACP_RS02100	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ACP_RS02110	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ACP_RS02150	COG4221	oxidoreductase activity
ACP_RS02175	COG2070	2-Nitropropane dioxygenase
ACP_RS02185	COG4191	Histidine kinase
ACP_RS02190	COG4566	intracellular signal transduction
ACP_RS02195	COG4566	intracellular signal transduction
ACP_RS02200	COG2801	Transposase and inactivated derivatives
ACP_RS02220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACP_RS02235	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ACP_RS02240	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ACP_RS02260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACP_RS02280	COG1294	oxidase, subunit
ACP_RS02285	COG1271	oxidase subunit
ACP_RS02350	COG0612	Peptidase, M16
ACP_RS02370	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACP_RS02375	COG4447	cellulose binding
ACP_RS02385	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACP_RS02390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACP_RS02395	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ACP_RS02400	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ACP_RS02405	COG0745	RESPONSE REGULATOR receiver
ACP_RS02430	COG0784	Response regulator, receiver
ACP_RS02435	COG3852	Histidine kinase
ACP_RS02440	COG0673	inositol 2-dehydrogenase activity
ACP_RS02450	COG2885	chlorophyll binding
ACP_RS02455	COG0823	Involved in the tonB-independent uptake of proteins
ACP_RS02460	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ACP_RS02475	COG0497	DNA recombination
ACP_RS02485	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ACP_RS02495	COG0617	tRNA 3'-terminal CCA addition
ACP_RS02505	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACP_RS02535	COG0217	transcriptional regulatory protein
ACP_RS02545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACP_RS02555	COG0297	glycogen (starch) synthase activity
ACP_RS02560	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACP_RS02570	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ACP_RS02575	COG3258	Cytochrome c
ACP_RS02585	COG2022	thiamine diphosphate biosynthetic process
ACP_RS02605	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ACP_RS02630	COG1278	Cold shock
ACP_RS02645	COG4447	cellulose binding
ACP_RS02660	COG2755	lipolytic protein G-D-S-L family
ACP_RS02665	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ACP_RS02690	COG4952	isomerase
ACP_RS02700	COG3347	Dehydrogenase
ACP_RS02700	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_RS02705	COG1070	Carbohydrate kinase
ACP_RS02710	COG2755	lipolytic protein G-D-S-L family
ACP_RS02765	COG2755	lipolytic protein G-D-S-L family
ACP_RS02780	COG0028	Belongs to the TPP enzyme family
ACP_RS02785	COG1088	dTDP-glucose 4,6-dehydratase activity
ACP_RS02795	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACP_RS02805	COG0463	Glycosyl transferase, family 2
ACP_RS02845	COG4122	O-methyltransferase activity
ACP_RS02855	COG0751	glycine-tRNA ligase activity
ACP_RS02860	COG0752	glycyl-tRNA synthetase alpha subunit
ACP_RS02865	COG1381	Involved in DNA repair and RecF pathway recombination
ACP_RS02905	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ACP_RS02910	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACP_RS02935	COG0077	Prephenate dehydratase
ACP_RS02935	COG1605	Chorismate mutase
ACP_RS02940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACP_RS02950	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ACP_RS02955	COG1573	uracil-dna glycosylase
ACP_RS02960	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACP_RS02970	COG0194	GDP metabolic process
ACP_RS02975	COG1561	YicC-like family, N-terminal region
ACP_RS02980	COG1132	(ABC) transporter
ACP_RS02985	COG1660	Displays ATPase and GTPase activities
ACP_RS02995	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ACP_RS03020	COG1174	glycine betaine transport
ACP_RS03025	COG1125	glycine betaine transport
ACP_RS03025	COG0517	IMP dehydrogenase activity
ACP_RS03035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACP_RS03045	COG0126	phosphoglycerate kinase activity
ACP_RS03060	COG0149	triose-phosphate isomerase activity
ACP_RS03075	COG1253	flavin adenine dinucleotide binding
ACP_RS03090	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ACP_RS03145	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
ACP_RS03150	COG1431	PFAM Stem cell self-renewal protein Piwi
ACP_RS03210	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_RS03225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACP_RS03225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACP_RS03240	COG2132	Multicopper oxidase
ACP_RS03250	COG1054	Belongs to the UPF0176 family
ACP_RS03255	COG2204	response regulator
ACP_RS03260	COG3852	Histidine kinase
ACP_RS03270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACP_RS03275	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ACP_RS03280	COG1940	carbohydrate kinase activity
ACP_RS03285	COG1755	Isoprenylcysteine carboxyl methyltransferase
ACP_RS03290	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ACP_RS03295	COG0505	Belongs to the CarA family
ACP_RS03305	COG0101	tRNA pseudouridine synthase activity
ACP_RS03335	COG1196	nuclear chromosome segregation
ACP_RS03345	COG1286	toxin biosynthetic process
ACP_RS03355	COG0546	phosphoglycolate phosphatase activity
ACP_RS03375	COG2197	response regulator
ACP_RS03385	COG0586	Pfam SNARE associated Golgi protein
ACP_RS03390	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ACP_RS03405	COG1587	Uroporphyrinogen-III synthase
ACP_RS03410	COG0181	hydroxymethylbilane synthase activity
ACP_RS03415	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ACP_RS03420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACP_RS03420	COG1333	cytochrome c biogenesis protein
ACP_RS03435	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ACP_RS03440	COG1472	Belongs to the glycosyl hydrolase 3 family
ACP_RS03450	COG4166	transmembrane transport
ACP_RS03455	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ACP_RS03460	COG0459	protein refolding
ACP_RS03480	COG0047	phosphoribosylformylglycinamidine synthase activity
ACP_RS03490	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_RS03515	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ACP_RS03555	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACP_RS03560	COG0436	Aminotransferase
ACP_RS03565	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACP_RS03565	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACP_RS03570	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ACP_RS03580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACP_RS03595	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ACP_RS03600	COG0438	transferase activity, transferring glycosyl groups
ACP_RS03640	COG3394	polysaccharide catabolic process
ACP_RS03645	COG0438	transferase activity, transferring glycosyl groups
ACP_RS03650	COG3275	phosphorelay sensor kinase activity
ACP_RS03660	COG2181	nitrate reductase activity
ACP_RS03660	COG0247	lactate metabolic process
ACP_RS03670	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ACP_RS03685	COG0589	response to stress
ACP_RS03730	COG3940	Belongs to the glycosyl hydrolase 43 family
ACP_RS03740	COG1518	maintenance of DNA repeat elements
ACP_RS03790	COG2814	Major facilitator Superfamily
ACP_RS03790	COG0477	Major facilitator Superfamily
ACP_RS03795	COG1609	Transcriptional regulator
ACP_RS03800	COG1940	carbohydrate kinase activity
ACP_RS03815	COG1573	uracil-dna glycosylase
ACP_RS03825	COG0443	Heat shock 70 kDa protein
ACP_RS03830	COG2827	Endonuclease containing a URI domain
ACP_RS03840	COG0484	heat shock protein binding
ACP_RS03845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACP_RS03855	COG0789	Transcriptional regulator
ACP_RS03875	COG0006	proline dipeptidase activity
ACP_RS03885	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ACP_RS03885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACP_RS03890	COG1562	ergosterol biosynthetic process
ACP_RS03900	COG1063	alcohol dehydrogenase
ACP_RS03905	COG1063	alcohol dehydrogenase
ACP_RS03915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACP_RS03945	COG1596	polysaccharide export
ACP_RS03990	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ACP_RS04005	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACP_RS04010	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ACP_RS04015	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ACP_RS04030	COG0366	Alpha amylase catalytic
ACP_RS04035	COG0366	Alpha amylase catalytic
ACP_RS04045	COG0463	Glycosyl transferase, family 2
ACP_RS04080	COG3420	alginic acid biosynthetic process
ACP_RS04090	COG0531	amino acid
ACP_RS04100	COG1349	DNA-binding transcription factor activity
ACP_RS04105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACP_RS04110	COG2222	sugar isomerase
ACP_RS04120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACP_RS04130	COG2183	response to ionizing radiation
ACP_RS04135	COG1874	Beta-galactosidase
ACP_RS04165	COG0577	efflux transmembrane transporter activity
ACP_RS04165	COG1136	(ABC) transporter
ACP_RS04175	COG0564	pseudouridine synthase activity
ACP_RS04180	COG1501	Belongs to the glycosyl hydrolase 31 family
ACP_RS04220	COG1136	(ABC) transporter
ACP_RS04245	COG0784	Response regulator, receiver
ACP_RS04250	COG4251	negative regulation of phosphorylation
ACP_RS04270	COG1136	(ABC) transporter
ACP_RS04270	COG0577	efflux transmembrane transporter activity
ACP_RS04280	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACP_RS04285	COG0302	gtp cyclohydrolase
ACP_RS04305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACP_RS04315	COG0351	phosphomethylpyrimidine kinase
ACP_RS04320	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACP_RS04325	COG0284	orotidine-5'-phosphate decarboxylase activity
ACP_RS04330	COG0577	efflux transmembrane transporter activity
ACP_RS04330	COG1136	(ABC) transporter
ACP_RS04335	COG1136	(ABC) transporter
ACP_RS04335	COG0577	efflux transmembrane transporter activity
ACP_RS04345	COG1874	Beta-galactosidase
ACP_RS04365	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACP_RS04390	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACP_RS04395	COG0004	ammonium transporteR
ACP_RS04400	COG0347	Belongs to the P(II) protein family
ACP_RS04405	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ACP_RS04425	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ACP_RS04445	COG1074	ATP-dependent DNA helicase activity
ACP_RS04455	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACP_RS04460	COG5002	protein histidine kinase activity
ACP_RS04465	COG0745	RESPONSE REGULATOR receiver
ACP_RS04470	COG0745	RESPONSE REGULATOR receiver
ACP_RS04485	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACP_RS04500	COG0300	oxidoreductase activity
ACP_RS04505	COG0314	molybdopterin synthase activity
ACP_RS04520	COG0483	inositol monophosphate 1-phosphatase activity
ACP_RS04540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACP_RS04550	COG0109	protoheme IX farnesyltransferase activity
ACP_RS04565	COG2322	membrane
ACP_RS04580	COG0835	chemotaxis
ACP_RS04590	COG2198	Histidine kinase
ACP_RS04590	COG0643	Histidine kinase
ACP_RS04600	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ACP_RS04605	COG0745	RESPONSE REGULATOR receiver
ACP_RS04615	COG2201	protein-glutamate methylesterase activity
ACP_RS04645	COG1832	CoA-binding protein
ACP_RS04650	COG4232	protein-disulfide reductase activity
ACP_RS04660	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ACP_RS04665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACP_RS04670	COG0009	L-threonylcarbamoyladenylate synthase
ACP_RS04695	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ACP_RS04700	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ACP_RS04715	COG0473	3-isopropylmalate dehydrogenase activity
ACP_RS04750	COG3546	catalase activity
ACP_RS04775	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ACP_RS04775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ACP_RS04780	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACP_RS04790	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ACP_RS04790	COG0646	methionine synthase
ACP_RS04795	COG1722	exodeoxyribonuclease VII activity
ACP_RS04800	COG0626	cystathionine gamma-synthase activity
ACP_RS04805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACP_RS04815	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACP_RS04825	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ACP_RS04830	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ACP_RS04835	COG3291	Pkd domain containing protein
ACP_RS04840	COG4702	Belongs to the UPF0303 family
ACP_RS04845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ACP_RS04850	COG1183	phosphatidylcholine synthase activity
ACP_RS04855	COG0688	phosphatidylethanolamine metabolic process
ACP_RS04865	COG0456	acetyltransferase
ACP_RS04875	COG0346	lactoylglutathione lyase activity
ACP_RS04890	COG1960	acyl-CoA dehydrogenase activity
ACP_RS04895	COG0631	protein serine/threonine phosphatase activity
ACP_RS04900	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACP_RS04905	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ACP_RS04910	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACP_RS04915	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACP_RS04920	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACP_RS04935	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ACP_RS04940	COG1923	regulation of RNA biosynthetic process
ACP_RS04950	COG0166	Belongs to the GPI family
ACP_RS04955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACP_RS04960	COG0662	Cupin 2, conserved barrel domain protein
ACP_RS04960	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ACP_RS04965	COG1482	cell wall glycoprotein biosynthetic process
ACP_RS04980	COG0535	radical SAM domain protein
ACP_RS04985	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ACP_RS04990	COG0367	asparagine synthase
ACP_RS05000	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACP_RS05000	COG1024	Enoyl-CoA hydratase
ACP_RS05010	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACP_RS05015	COG1595	DNA-templated transcription, initiation
ACP_RS05025	COG2154	pterin-4-alpha-carbinolamine dehydratase
ACP_RS05040	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACP_RS05045	COG1295	ribonuclease BN
ACP_RS05060	COG1408	metallophosphoesterase
ACP_RS05065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACP_RS05080	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ACP_RS05085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACP_RS05100	COG0454	-acetyltransferase
ACP_RS05100	COG0456	acetyltransferase
ACP_RS05115	COG1472	Belongs to the glycosyl hydrolase 3 family
ACP_RS05120	COG2197	response regulator
ACP_RS05125	COG4585	Histidine kinase
ACP_RS05135	COG1131	(ABC) transporter
ACP_RS05140	COG1695	Transcriptional regulator
ACP_RS05155	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACP_RS05165	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ACP_RS05170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACP_RS05190	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACP_RS05195	COG0772	Belongs to the SEDS family
ACP_RS05200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACP_RS05205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACP_RS05210	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ACP_RS05215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACP_RS05230	COG0275	rRNA processing
ACP_RS05235	COG2001	Belongs to the MraZ family
ACP_RS05255	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ACP_RS05290	COG4964	Belongs to the GSP D family
ACP_RS05325	COG0519	Catalyzes the synthesis of GMP from XMP
ACP_RS05325	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACP_RS05335	COG0495	leucyl-tRNA aminoacylation
ACP_RS05340	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ACP_RS05345	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ACP_RS05360	COG0676	glucose-6-phosphate 1-epimerase activity
ACP_RS05365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACP_RS05370	COG0800	Aldolase
ACP_RS05375	COG4948	Mandelate Racemase Muconate Lactonizing
ACP_RS05385	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_RS05395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACP_RS05450	COG3534	alpha-L-arabinofuranosidase
ACP_RS05465	COG0297	glycogen (starch) synthase activity
ACP_RS05520	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACP_RS05535	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACP_RS05560	COG0529	Catalyzes the synthesis of activated sulfate
ACP_RS05580	COG1132	(ABC) transporter
ACP_RS05690	COG4962	Type ii secretion system protein e
ACP_RS05730	COG2217	Heavy metal translocating P-type atpase
ACP_RS05735	COG0701	Predicted permease
ACP_RS05745	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACP_RS05750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACP_RS05760	COG0640	Transcriptional regulator
ACP_RS05810	COG2132	Multicopper oxidase
ACP_RS05850	COG1475	DNA binding
ACP_RS05885	COG2608	mercury ion transmembrane transporter activity
ACP_RS05910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ACP_RS05915	COG1612	heme a metabolic process
ACP_RS05915	COG0109	protoheme IX farnesyltransferase activity
ACP_RS05930	COG0322	excinuclease ABC activity
ACP_RS05950	COG0631	protein serine/threonine phosphatase activity
ACP_RS05975	COG0174	glutamine synthetase
ACP_RS05980	COG0515	serine threonine protein kinase
ACP_RS05995	COG0475	glutathione-regulated potassium exporter activity
ACP_RS06005	COG0004	ammonium transporteR
ACP_RS06030	COG0745	RESPONSE REGULATOR receiver
ACP_RS06035	COG0642	Histidine kinase
ACP_RS06050	COG3250	beta-galactosidase activity
ACP_RS06055	COG0531	amino acid
ACP_RS06090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ACP_RS06115	COG3128	pkhd-type hydroxylase
ACP_RS06120	COG4774	siderophore transport
ACP_RS06135	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_RS06150	COG1902	pentaerythritol trinitrate reductase activity
ACP_RS06200	COG4585	Histidine kinase
ACP_RS06205	COG2197	response regulator
ACP_RS06210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACP_RS06255	COG0745	RESPONSE REGULATOR receiver
ACP_RS06345	COG1012	belongs to the aldehyde dehydrogenase family
ACP_RS06355	COG2197	response regulator
ACP_RS06370	COG2801	Transposase and inactivated derivatives
ACP_RS06385	COG1595	DNA-templated transcription, initiation
ACP_RS06405	COG0506	proline dehydrogenase activity
ACP_RS06410	COG3706	GGDEF domain
ACP_RS06420	COG0778	Nitroreductase
ACP_RS06430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACP_RS06450	COG2814	Major facilitator Superfamily
ACP_RS06465	COG1349	DNA-binding transcription factor activity
ACP_RS06470	COG3142	Participates in the control of copper homeostasis
ACP_RS06485	COG1695	Transcriptional regulator
ACP_RS06515	COG4447	cellulose binding
ACP_RS06535	COG1569	PIN domain
ACP_RS06565	COG1136	(ABC) transporter
ACP_RS06575	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACP_RS06590	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ACP_RS06600	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACP_RS06625	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ACP_RS06630	COG0492	ferredoxin-NADP+ reductase activity
ACP_RS06640	COG0305	Participates in initiation and elongation during chromosome replication
ACP_RS06645	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ACP_RS06655	COG2040	homocysteine
ACP_RS06680	COG1136	(ABC) transporter
ACP_RS06680	COG0577	efflux transmembrane transporter activity
ACP_RS06690	COG3537	Alpha-1,2-mannosidase
ACP_RS06700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACP_RS06710	COG1335	isochorismatase
ACP_RS06715	COG0477	Major facilitator Superfamily
ACP_RS06770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACP_RS06790	COG0596	Alpha beta hydrolase
ACP_RS06795	COG1309	transcriptional regulator
ACP_RS06800	COG0203	ribosomal protein L17
ACP_RS06805	COG0202	RNA polymerase activity
ACP_RS06810	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACP_RS06815	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ACP_RS06820	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACP_RS06825	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ACP_RS06830	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACP_RS06840	COG0563	adenylate kinase activity
ACP_RS06850	COG0200	Binds to the 23S rRNA
ACP_RS06855	COG1841	ribosomal large subunit assembly
ACP_RS06860	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACP_RS06865	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACP_RS06870	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACP_RS06875	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACP_RS06880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACP_RS06885	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACP_RS06890	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ACP_RS06895	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACP_RS06900	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACP_RS06905	COG0255	Belongs to the universal ribosomal protein uL29 family
ACP_RS06910	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACP_RS06915	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACP_RS06920	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACP_RS06925	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACP_RS06930	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACP_RS06935	COG0089	rRNA binding
ACP_RS06940	COG0088	Forms part of the polypeptide exit tunnel
ACP_RS06945	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACP_RS06950	COG0051	transcription antitermination factor activity, RNA binding
ACP_RS06955	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACP_RS06960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACP_RS06965	COG0049	tRNA binding
ACP_RS06970	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACP_RS06980	COG1506	peptidase
ACP_RS06980	COG4946	Tricorn protease homolog
ACP_RS06980	COG0823	Involved in the tonB-independent uptake of proteins
ACP_RS06995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACP_RS07000	COG0473	3-isopropylmalate dehydrogenase activity
ACP_RS07010	COG0527	aspartate kinase activity
ACP_RS07015	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ACP_RS07025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACP_RS07035	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ACP_RS07060	COG0784	Response regulator, receiver
ACP_RS07060	COG2198	Histidine kinase
ACP_RS07060	COG2205	protein histidine kinase activity
ACP_RS07060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACP_RS07065	COG2197	response regulator
ACP_RS07080	COG4221	oxidoreductase activity
ACP_RS07090	COG3321	synthase
ACP_RS07090	COG0604	alcohol dehydrogenase
ACP_RS07090	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_RS07100	COG1131	(ABC) transporter
ACP_RS07105	COG0842	Transport permease protein
ACP_RS07120	COG0492	ferredoxin-NADP+ reductase activity
ACP_RS07125	COG1027	Aspartate ammonia-lyase
ACP_RS07140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACP_RS07170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACP_RS07175	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACP_RS07180	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ACP_RS07230	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ACP_RS07235	COG0628	permease
ACP_RS07250	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ACP_RS07260	COG2135	peptidase activity
ACP_RS07265	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACP_RS07275	COG0587	DNA-directed DNA polymerase activity
ACP_RS07290	COG0577	efflux transmembrane transporter activity
ACP_RS07290	COG1136	(ABC) transporter
ACP_RS07305	COG1695	Transcriptional regulator
ACP_RS07310	COG0577	efflux transmembrane transporter activity
ACP_RS07310	COG1136	(ABC) transporter
ACP_RS07315	COG0577	efflux transmembrane transporter activity
ACP_RS07315	COG1136	(ABC) transporter
ACP_RS07320	COG1136	(ABC) transporter
ACP_RS07320	COG0577	efflux transmembrane transporter activity
ACP_RS07345	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ACP_RS07345	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ACP_RS07365	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ACP_RS07375	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ACP_RS07445	COG4555	ABC transporter
ACP_RS07530	COG2197	response regulator
ACP_RS07535	COG1136	(ABC) transporter
ACP_RS07535	COG0577	efflux transmembrane transporter activity
ACP_RS07550	COG2801	Transposase and inactivated derivatives
ACP_RS07570	COG0589	response to stress
ACP_RS07620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACP_RS07630	COG1733	regulation of RNA biosynthetic process
ACP_RS07680	COG1136	(ABC) transporter
ACP_RS07710	COG0859	PFAM glycosyl transferase family 9
ACP_RS07715	COG1663	tetraacyldisaccharide 4'-kinase activity
ACP_RS07720	COG1519	Transferase
ACP_RS07735	COG0750	zinc metalloprotease
ACP_RS07740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ACP_RS07745	COG0575	Belongs to the CDS family
ACP_RS07755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACP_RS07760	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACP_RS07765	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACP_RS07780	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ACP_RS07790	COG0494	nUDIX hydrolase
ACP_RS07795	COG1278	Cold shock
ACP_RS07800	COG1796	DNA polymerase
ACP_RS07800	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ACP_RS07810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACP_RS07815	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACP_RS07820	COG0776	regulation of translation
ACP_RS07835	COG1131	(ABC) transporter
ACP_RS07845	COG1505	serine-type exopeptidase activity
ACP_RS07860	COG3852	Histidine kinase
ACP_RS07865	COG1501	Belongs to the glycosyl hydrolase 31 family
ACP_RS07880	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACP_RS07900	COG0482	sulfurtransferase activity
ACP_RS07905	COG1160	GTP binding
ACP_RS07920	COG1199	ATP-dependent helicase activity
ACP_RS07965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACP_RS07975	COG1024	Enoyl-CoA hydratase
ACP_RS07990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACP_RS08000	COG0640	Transcriptional regulator
ACP_RS08025	COG1530	ribonuclease E activity
ACP_RS08025	COG1530	ribonuclease E activity
ACP_RS08030	COG0772	Belongs to the SEDS family
ACP_RS08045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACP_RS08075	COG0768	penicillin binding
ACP_RS08095	COG1012	belongs to the aldehyde dehydrogenase family
ACP_RS08105	COG0686	Belongs to the AlaDH PNT family
ACP_RS08115	COG5000	phosphorelay sensor kinase activity
ACP_RS08120	COG2204	response regulator
ACP_RS08145	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACP_RS08155	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACP_RS08165	COG1136	(ABC) transporter
ACP_RS08165	COG0577	efflux transmembrane transporter activity
ACP_RS08180	COG0668	transmembrane transport
ACP_RS08195	COG0268	Binds directly to 16S ribosomal RNA
ACP_RS08210	COG0489	protein tyrosine kinase activity
ACP_RS08240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACP_RS08245	COG1201	RNA secondary structure unwinding
ACP_RS08265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ACP_RS08275	COG0572	uridine kinase
ACP_RS08280	COG1215	transferase activity, transferring glycosyl groups
ACP_RS08290	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_RS08300	COG1899	peptidyl-lysine modification to peptidyl-hypusine
ACP_RS08315	COG0745	RESPONSE REGULATOR receiver
ACP_RS08335	COG1570	exodeoxyribonuclease VII activity
ACP_RS08340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACP_RS08345	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACP_RS08345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACP_RS08350	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ACP_RS08365	COG4152	abc transporter atp-binding protein
ACP_RS08370	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ACP_RS08375	COG1945	arginine decarboxylase activity
ACP_RS08385	COG2957	Belongs to the agmatine deiminase family
ACP_RS08425	COG0792	nuclease activity
ACP_RS08465	COG1064	alcohol dehydrogenase
ACP_RS08480	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ACP_RS08490	COG0159	tryptophan synthase activity
ACP_RS08495	COG0133	tryptophan synthase activity
ACP_RS08500	COG0135	phosphoribosylanthranilate isomerase activity
ACP_RS08505	COG0134	indole-3-glycerol-phosphate synthase activity
ACP_RS08520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACP_RS08525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACP_RS08560	COG3852	Histidine kinase
ACP_RS08580	COG0372	Belongs to the citrate synthase family
ACP_RS08590	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_RS08595	COG0210	DNA helicase
ACP_RS08600	COG0531	amino acid
ACP_RS08625	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ACP_RS08650	COG0175	sulfate reduction
ACP_RS08660	COG0251	oxidation-reduction process
ACP_RS08670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACP_RS08680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACP_RS08685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACP_RS08695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACP_RS08700	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
ACP_RS08710	COG0358	DNA primase activity
ACP_RS08740	COG2234	aminopeptidase activity
ACP_RS08760	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACP_RS08770	COG0072	phenylalanine-tRNA ligase activity
ACP_RS08770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACP_RS08780	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ACP_RS08795	COG0564	pseudouridine synthase activity
ACP_RS08800	COG1764	response to oxidative stress
ACP_RS08810	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACP_RS08815	COG2081	HI0933 family
ACP_RS08835	COG1595	DNA-templated transcription, initiation
ACP_RS08850	COG0303	'Molybdopterin
ACP_RS08860	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ACP_RS08875	COG0659	secondary active sulfate transmembrane transporter activity
ACP_RS08880	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ACP_RS08885	COG1136	(ABC) transporter
ACP_RS08885	COG0577	efflux transmembrane transporter activity
ACP_RS08905	COG1032	radical SAM domain protein
ACP_RS08930	COG0154	amidase activity
ACP_RS08935	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACP_RS08985	COG1012	belongs to the aldehyde dehydrogenase family
ACP_RS08990	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ACP_RS09010	COG1295	ribonuclease BN
ACP_RS09020	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ACP_RS09030	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ACP_RS09055	COG1595	DNA-templated transcription, initiation
ACP_RS09060	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ACP_RS09075	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACP_RS09075	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACP_RS09085	COG2271	Major facilitator Superfamily
ACP_RS09090	COG2706	6-phosphogluconolactonase activity
ACP_RS09095	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ACP_RS09105	COG0424	maF-like protein
ACP_RS09110	COG1446	asparaginase
ACP_RS09125	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACP_RS09125	COG0315	cyclic pyranopterin monophosphate synthase activity
ACP_RS09140	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ACP_RS09155	COG0156	8-amino-7-oxononanoate synthase activity
ACP_RS09160	COG3590	peptidase
ACP_RS09190	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ACP_RS09200	COG0416	fatty acid biosynthetic process
ACP_RS09205	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ACP_RS09215	COG0277	FAD linked oxidase domain protein
ACP_RS09245	COG4095	Psort location CytoplasmicMembrane, score
ACP_RS09280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACP_RS09290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACP_RS09290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACP_RS09335	COG0515	serine threonine protein kinase
ACP_RS09335	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACP_RS09340	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
ACP_RS09355	COG1476	TRANSCRIPTIONal
ACP_RS09365	COG1950	PFAM Membrane protein of
ACP_RS09385	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACP_RS09405	COG1819	glycosyl
ACP_RS09420	COG5520	Belongs to the glycosyl hydrolase 30 family
ACP_RS09425	COG2814	Major facilitator Superfamily
ACP_RS09435	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ACP_RS09440	COG0726	polysaccharide deacetylase
ACP_RS09445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACP_RS09450	COG0237	dephospho-CoA kinase activity
ACP_RS09455	COG2835	tetraacyldisaccharide 4'-kinase activity
ACP_RS09465	COG0693	protein deglycase activity
ACP_RS09470	COG0606	chelatase, subunit chli
ACP_RS09505	COG1595	DNA-templated transcription, initiation
ACP_RS09520	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ACP_RS09560	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ACP_RS09565	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACP_RS09585	COG1136	(ABC) transporter
ACP_RS09585	COG0577	efflux transmembrane transporter activity
ACP_RS09590	COG1136	(ABC) transporter
ACP_RS09590	COG0577	efflux transmembrane transporter activity
ACP_RS09605	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ACP_RS09610	COG0540	Belongs to the ATCase OTCase family
ACP_RS09615	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACP_RS09620	COG0557	exoribonuclease II activity
ACP_RS09630	COG1902	pentaerythritol trinitrate reductase activity
ACP_RS09650	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACP_RS09665	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
ACP_RS09670	COG0151	Belongs to the GarS family
ACP_RS09690	COG0776	regulation of translation
ACP_RS09705	COG1201	RNA secondary structure unwinding
ACP_RS09715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACP_RS09720	COG0571	ribonuclease III activity
ACP_RS09725	COG0681	Belongs to the peptidase S26 family
ACP_RS09730	COG0681	Belongs to the peptidase S26 family
ACP_RS09745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACP_RS09770	COG3279	Response regulator of the LytR AlgR family
ACP_RS09800	COG0632	four-way junction helicase activity
ACP_RS09820	COG1040	competence protein
ACP_RS09835	COG1297	OPT oligopeptide transporter protein
ACP_RS09840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACP_RS09845	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACP_RS09850	COG0359	binds to the 23S rRNA
ACP_RS09855	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACP_RS09860	COG0360	Binds together with S18 to 16S ribosomal RNA
ACP_RS09865	COG0193	aminoacyl-tRNA hydrolase activity
ACP_RS09870	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ACP_RS09875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACP_RS09885	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACP_RS09900	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACP_RS09905	COG0537	adenosine 5'-monophosphoramidase activity
ACP_RS09910	COG0012	GTP binding
ACP_RS09920	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ACP_RS09925	COG2255	four-way junction helicase activity
ACP_RS09940	COG3177	Filamentation induced by cAMP protein fic
ACP_RS09955	COG1420	regulation of RNA biosynthetic process
ACP_RS09960	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACP_RS09965	COG0484	heat shock protein binding
ACP_RS09975	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACP_RS09985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACP_RS10000	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACP_RS10005	COG0509	glycine decarboxylation via glycine cleavage system
ACP_RS10010	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACP_RS10015	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACP_RS10055	COG1472	Belongs to the glycosyl hydrolase 3 family
ACP_RS10065	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACP_RS10075	COG4585	Histidine kinase
ACP_RS10080	COG2197	response regulator
ACP_RS10100	COG0706	membrane insertase activity
ACP_RS10100	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
ACP_RS10105	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ACP_RS10110	COG0594	ribonuclease P activity
ACP_RS10120	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACP_RS10130	COG0577	efflux transmembrane transporter activity
ACP_RS10130	COG1136	(ABC) transporter
ACP_RS10150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACP_RS10150	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ACP_RS10160	COG0673	inositol 2-dehydrogenase activity
ACP_RS10165	COG4770	biotin carboxylase activity
ACP_RS10170	COG0439	Biotin carboxylase
ACP_RS10200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACP_RS10205	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACP_RS10210	COG1862	Preprotein translocase
ACP_RS10225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACP_RS10245	COG2755	lipolytic protein G-D-S-L family
ACP_RS10245	COG0657	acetylesterase activity
ACP_RS10270	COG0343	queuine tRNA-ribosyltransferase activity
ACP_RS10285	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACP_RS10290	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACP_RS10295	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ACP_RS10300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACP_RS10310	COG1192	Involved in chromosome partitioning
ACP_RS10335	COG0285	dihydrofolate synthase activity
ACP_RS10345	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ACP_RS10350	COG0357	Ribosomal RNA small subunit methyltransferase G
ACP_RS10360	COG1475	DNA binding
ACP_RS10400	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ACP_RS10415	COG3609	addiction module antidote protein, CC2985 family
ACP_RS10425	COG0113	porphobilinogen synthase activity
ACP_RS10435	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ACP_RS10440	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ACP_RS10465	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ACP_RS10470	COG4191	Histidine kinase
ACP_RS10480	COG2855	membrane
ACP_RS10485	COG0583	DNA-binding transcription factor activity
ACP_RS10495	COG0017	Asparaginyl-tRNA synthetase
ACP_RS10510	COG3093	addiction module antidote protein HigA
ACP_RS10515	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACP_RS10540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACP_RS10555	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACP_RS10560	COG0475	glutathione-regulated potassium exporter activity
ACP_RS10565	COG0697	spore germination
ACP_RS10570	COG0215	cysteine-tRNA ligase activity
ACP_RS10575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACP_RS10585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACP_RS10595	COG0300	oxidoreductase activity
ACP_RS10605	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACP_RS10625	COG0037	tRNA processing
ACP_RS10635	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACP_RS10640	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ACP_RS10675	COG2226	methyltransferase
ACP_RS10680	COG1366	Belongs to the anti-sigma-factor antagonist family
ACP_RS10695	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ACP_RS10700	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACP_RS10705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACP_RS10710	COG2027	D-alanyl-D-alanine carboxypeptidase
ACP_RS10720	COG1428	Deoxynucleoside kinase
ACP_RS10730	COG0745	RESPONSE REGULATOR receiver
ACP_RS10745	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ACP_RS10760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACP_RS10765	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACP_RS10785	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ACP_RS10790	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ACP_RS10795	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ACP_RS10810	COG1193	negative regulation of DNA recombination
ACP_RS10835	COG0698	ribose 5-phosphate isomerase
ACP_RS10840	COG1011	Hydrolase
ACP_RS10845	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ACP_RS10850	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ACP_RS10855	COG0363	glucosamine-6-phosphate deaminase activity
ACP_RS10860	COG0837	glucose binding
ACP_RS10865	COG3781	membrane
ACP_RS10885	COG2094	Belongs to the DNA glycosylase MPG family
ACP_RS10890	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACP_RS10915	COG0058	SHG alpha-glucan phosphorylase activity
ACP_RS10920	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ACP_RS10925	COG0076	glutamate decarboxylase activity
ACP_RS10930	COG1278	Cold shock
ACP_RS10935	COG3590	peptidase
ACP_RS10945	COG1215	transferase activity, transferring glycosyl groups
ACP_RS10960	COG1012	belongs to the aldehyde dehydrogenase family
ACP_RS10975	COG1872	DUF167
ACP_RS10980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ACP_RS10985	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ACP_RS11005	COG1760	l-serine dehydratase
ACP_RS11010	COG0233	cytoplasmic translational termination
ACP_RS11020	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACP_RS11025	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ACP_RS11035	COG0539	negative regulation of cytoplasmic translation
ACP_RS11040	COG2080	2 iron, 2 sulfur cluster binding
ACP_RS11045	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ACP_RS11050	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACP_RS11060	COG0746	molybdenum cofactor guanylyltransferase activity
ACP_RS11070	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ACP_RS11080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACP_RS11090	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACP_RS11095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACP_RS11100	COG1024	Enoyl-CoA hydratase
ACP_RS11110	COG0247	lactate metabolic process
ACP_RS11110	COG0277	FAD linked oxidase domain protein
ACP_RS11120	COG0436	Aminotransferase
ACP_RS11125	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACP_RS11130	COG0107	imidazoleglycerol-phosphate synthase activity
ACP_RS11135	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ACP_RS11140	COG0131	Imidazoleglycerol-phosphate dehydratase
ACP_RS11150	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACP_RS11155	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ACP_RS11160	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACP_RS11165	COG2205	protein histidine kinase activity
ACP_RS11165	COG0745	RESPONSE REGULATOR receiver
ACP_RS11165	COG4191	Histidine kinase
ACP_RS11170	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ACP_RS11180	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACP_RS11190	COG0124	histidyl-tRNA synthetase
ACP_RS11195	COG0445	tRNA wobble uridine modification
ACP_RS11200	COG0513	Belongs to the DEAD box helicase family
ACP_RS11215	COG0025	NhaP-type Na H and K H
ACP_RS11220	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACP_RS11225	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ACP_RS11230	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACP_RS11335	COG0352	thiamine-phosphate diphosphorylase activity
ACP_RS11345	COG0535	radical SAM domain protein
ACP_RS11375	COG1610	YqeY-like protein
ACP_RS11380	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ACP_RS11385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACP_RS11395	COG1968	undecaprenyl-diphosphatase activity
ACP_RS11400	COG1960	acyl-CoA dehydrogenase activity
ACP_RS11430	COG3258	Cytochrome c
ACP_RS11450	COG0542	response to heat
ACP_RS11465	COG0038	chloride channel
ACP_RS11480	COG1472	Belongs to the glycosyl hydrolase 3 family
ACP_RS11490	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACP_RS11495	COG1472	Belongs to the glycosyl hydrolase 3 family
ACP_RS11505	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
ACP_RS11510	COG0243	molybdopterin cofactor binding
ACP_RS11515	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACP_RS11535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACP_RS11545	COG1611	Belongs to the LOG family
ACP_RS11555	COG3250	beta-galactosidase activity
ACP_RS11560	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ACP_RS11565	COG4946	Tricorn protease homolog
ACP_RS11565	COG0823	Involved in the tonB-independent uptake of proteins
ACP_RS11565	COG1506	peptidase
ACP_RS11570	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACP_RS11575	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACP_RS11585	COG1565	acr, cog1565
ACP_RS11585	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ACP_RS11620	COG2314	TM2 domain
ACP_RS11665	COG0504	CTP synthase activity
ACP_RS11675	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ACP_RS11685	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_RS11690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACP_RS11690	COG2169	Transcriptional regulator
ACP_RS11700	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACP_RS11715	COG0825	malonyl-CoA metabolic process
ACP_RS11720	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_RS11725	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACP_RS11755	COG2095	MarC family integral membrane protein
ACP_RS11845	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ACP_RS11855	COG1725	Transcriptional regulator
ACP_RS11860	COG1131	(ABC) transporter
ACP_RS11880	COG4591	ABC-type transport system involved in lipoprotein release permease component
ACP_RS11880	COG1136	(ABC) transporter
ACP_RS11890	COG1136	(ABC) transporter
ACP_RS11890	COG0577	efflux transmembrane transporter activity
ACP_RS11900	COG2204	response regulator
ACP_RS11905	COG4191	Histidine kinase
ACP_RS11915	COG0577	efflux transmembrane transporter activity
ACP_RS11920	COG0577	efflux transmembrane transporter activity
ACP_RS11920	COG1136	(ABC) transporter
ACP_RS11945	COG0366	Alpha amylase catalytic
ACP_RS11950	COG1764	response to oxidative stress
ACP_RS11960	COG0745	RESPONSE REGULATOR receiver
ACP_RS11970	COG0366	Alpha amylase catalytic
ACP_RS11975	COG0667	Aldo Keto reductase
ACP_RS12025	COG2814	Major facilitator Superfamily
ACP_RS12035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACP_RS12040	COG1136	(ABC) transporter
ACP_RS12050	COG0071	Belongs to the small heat shock protein (HSP20) family
ACP_RS12080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACP_RS12085	COG1959	2 iron, 2 sulfur cluster binding
ACP_RS12090	COG1104	cysteine desulfurase activity
ACP_RS12100	COG0316	Belongs to the HesB IscA family
ACP_RS12105	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ACP_RS12110	COG1942	4-Oxalocrotonate Tautomerase
ACP_RS12115	COG0443	Heat shock 70 kDa protein
ACP_RS12120	COG0633	Ferredoxin
ACP_RS12125	COG2975	iron-sulfur cluster assembly
ACP_RS12155	COG0450	alkyl hydroperoxide reductase
ACP_RS12175	COG1136	(ABC) transporter
ACP_RS12195	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACP_RS12200	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACP_RS12210	COG0649	NAD binding
ACP_RS12220	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACP_RS12235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACP_RS12240	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACP_RS12250	COG1007	ATP synthesis coupled electron transport
ACP_RS12255	COG1234	tRNA 3'-trailer cleavage
ACP_RS12270	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ACP_RS12285	COG0525	valine-tRNA ligase activity
ACP_RS12295	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ACP_RS12310	COG1187	pseudouridine synthase activity
ACP_RS12315	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ACP_RS12325	COG0180	Tryptophanyl-tRNA synthetase
ACP_RS12330	COG1994	Peptidase M50
ACP_RS12335	COG0662	Cupin 2, conserved barrel domain protein
ACP_RS12350	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACP_RS12365	COG4964	Belongs to the GSP D family
ACP_RS12415	COG2801	Transposase and inactivated derivatives
ACP_RS12430	COG0045	succinate-CoA ligase (ADP-forming) activity
ACP_RS12440	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ACP_RS12455	COG0105	UTP biosynthetic process
ACP_RS12465	COG0667	Aldo Keto reductase
ACP_RS12485	COG0322	excinuclease ABC activity
ACP_RS12490	COG0312	modulator of DNA gyrase
ACP_RS12495	COG0312	modulator of DNA gyrase
ACP_RS12500	COG2318	DinB family
ACP_RS12515	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ACP_RS12520	COG1217	gtp-binding protein TYPA
ACP_RS12540	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACP_RS12545	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACP_RS12555	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACP_RS12560	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACP_RS12570	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACP_RS12580	COG0741	lytic transglycosylase activity
ACP_RS12580	COG1388	LysM domain
ACP_RS12585	COG0481	GTPase activity
ACP_RS12590	COG0657	acetylesterase activity
ACP_RS12600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACP_RS12610	COG0577	efflux transmembrane transporter activity
ACP_RS12610	COG1136	(ABC) transporter
ACP_RS12615	COG2309	aminopeptidase activity
ACP_RS12620	COG2890	protein-(glutamine-N5) methyltransferase activity
ACP_RS12625	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACP_RS12630	COG1793	dna ligase
ACP_RS12650	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ACP_RS12655	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ACP_RS12705	COG1914	H( )-stimulated, divalent metal cation uptake system
ACP_RS12710	COG1321	iron dependent repressor
ACP_RS12740	COG3220	belongs to the UPF0276 family
ACP_RS12770	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_RS12785	COG2271	Major facilitator Superfamily
ACP_RS12790	COG1904	glucuronate isomerase
ACP_RS12795	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACP_RS12795	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ACP_RS12795	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACP_RS12795	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACP_RS12805	COG2815	serine threonine protein kinase
ACP_RS12805	COG0515	serine threonine protein kinase
ACP_RS12815	COG0745	RESPONSE REGULATOR receiver
ACP_RS12830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACP_RS12835	COG3258	Cytochrome c
ACP_RS12840	COG0602	queuosine metabolic process
ACP_RS12845	COG0720	synthase
ACP_RS12885	COG1022	Amp-dependent synthetase and ligase
ACP_RS12890	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ACP_RS12905	COG1012	belongs to the aldehyde dehydrogenase family
ACP_RS12925	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ACP_RS12930	COG1360	Flagellar Motor Protein
ACP_RS12940	COG2208	phosphoserine phosphatase activity
ACP_RS12955	COG3511	phospholipase C
ACP_RS12975	COG1858	cytochrome C peroxidase
ACP_RS12985	COG3511	phospholipase C
ACP_RS12990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACP_RS13000	COG1045	serine acetyltransferase
ACP_RS13005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACP_RS13015	COG3459	Glycosyltransferase 36 associated
ACP_RS13045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACP_RS13065	COG0187	DNA topoisomerase II activity
ACP_RS13080	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ACP_RS13085	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ACP_RS13115	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ACP_RS13120	COG4191	Histidine kinase
ACP_RS13130	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACP_RS13145	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ACP_RS13160	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ACP_RS13170	COG0542	response to heat
ACP_RS13175	COG1136	(ABC) transporter
ACP_RS13240	COG1138	Cytochrome C-type biogenesis protein
ACP_RS13260	COG1506	peptidase
ACP_RS13260	COG0823	Involved in the tonB-independent uptake of proteins
ACP_RS13265	COG0546	phosphoglycolate phosphatase activity
ACP_RS13270	COG0556	nucleotide-excision repair
ACP_RS13275	COG1069	ribulokinase activity
ACP_RS13305	COG1609	Transcriptional regulator
ACP_RS13315	COG1063	alcohol dehydrogenase
ACP_RS13345	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACP_RS13350	COG0335	large ribosomal subunit rRNA binding
ACP_RS13365	COG0336	Belongs to the RNA methyltransferase TrmD family
ACP_RS13370	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ACP_RS13375	COG1837	Belongs to the UPF0109 family
ACP_RS13380	COG0228	four-way junction DNA binding
ACP_RS13385	COG5002	protein histidine kinase activity
ACP_RS13390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACP_RS13395	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ACP_RS13400	COG2814	Major facilitator Superfamily
ACP_RS13420	COG0667	Aldo Keto reductase
ACP_RS13425	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACP_RS13430	COG0183	Belongs to the thiolase family
ACP_RS13435	COG1960	acyl-CoA dehydrogenase activity
ACP_RS13450	COG3684	Belongs to the aldolase LacD family
ACP_RS13455	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ACP_RS13465	COG2204	response regulator
ACP_RS13485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACP_RS13490	COG0442	prolyl-tRNA aminoacylation
ACP_RS13500	COG0824	Thioesterase
ACP_RS13515	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACP_RS13515	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACP_RS13520	COG0745	RESPONSE REGULATOR receiver
ACP_RS13525	COG0142	geranyltranstransferase activity
ACP_RS13530	COG1666	GTP binding
ACP_RS13535	COG0084	hydrolase, TatD family'
ACP_RS13545	COG0018	arginyl-trna synthetase
ACP_RS13560	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACP_RS13570	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACP_RS13580	COG0501	Belongs to the peptidase M48B family
ACP_RS13585	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACP_RS13610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACP_RS13625	COG0321	lipoyl(octanoyl) transferase activity
ACP_RS13640	COG2205	protein histidine kinase activity
ACP_RS13645	COG3158	transport of potassium into the cell
ACP_RS13665	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ACP_RS13675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACP_RS13680	COG1254	Belongs to the acylphosphatase family
ACP_RS13695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACP_RS13705	COG0512	Glutamine amidotransferase of anthranilate synthase
ACP_RS13725	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ACP_RS13765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACP_RS13795	COG0778	Nitroreductase
ACP_RS13810	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ACP_RS13820	COG0742	ribosomal rna small subunit methyltransferase
ACP_RS13830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACP_RS13835	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ACP_RS13840	COG0739	heme binding
ACP_RS13885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACP_RS13890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACP_RS13910	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACP_RS13915	COG0081	regulation of translation
ACP_RS13920	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACP_RS13925	COG0222	ribosome binding
ACP_RS13930	COG0085	RNA polymerase activity
ACP_RS13935	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACP_RS13945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ACP_RS13950	COG0667	Aldo Keto reductase
ACP_RS13965	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACP_RS13990	COG1309	transcriptional regulator
ACP_RS13995	COG2814	Major facilitator Superfamily
ACP_RS14000	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACP_RS14005	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACP_RS14010	COG0052	Belongs to the universal ribosomal protein uS2 family
ACP_RS14015	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACP_RS14020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACP_RS14025	COG0528	UMP kinase activity
ACP_RS14045	COG3590	peptidase
ACP_RS14060	COG1472	Belongs to the glycosyl hydrolase 3 family
ACP_RS14070	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACP_RS14075	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACP_RS14105	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ACP_RS14115	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACP_RS14120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ACP_RS14130	COG0167	dihydroorotate dehydrogenase activity
ACP_RS14135	COG1877	trehalose-phosphatase activity
ACP_RS14140	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ACP_RS14160	COG2239	Acts as a magnesium transporter
ACP_RS14170	COG0494	nUDIX hydrolase
ACP_RS14185	COG4974	Belongs to the 'phage' integrase family
ACP_RS14195	COG0653	protein targeting
ACP_RS14205	COG0009	L-threonylcarbamoyladenylate synthase
ACP_RS14215	COG0470	DNA polymerase III
ACP_RS14220	COG2124	cytochrome p450
ACP_RS14225	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACP_RS14230	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ACP_RS14235	COG0165	Argininosuccinate lyase
ACP_RS14240	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACP_RS14245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACP_RS14250	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACP_RS14255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACP_RS14260	COG1438	arginine binding
ACP_RS14265	COG0067	glutamate synthase
ACP_RS14265	COG0070	glutamate synthase
ACP_RS14265	COG0069	glutamate synthase activity
ACP_RS14295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACP_RS14305	COG1704	LemA family
ACP_RS14315	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACP_RS14345	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_RS14350	COG3387	PFAM Glycoside hydrolase 15-related
ACP_RS14355	COG0730	response to heat
ACP_RS14365	COG1648	precorrin-2 dehydrogenase activity
ACP_RS14365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACP_RS14370	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACP_RS14390	COG2986	histidine ammonia-lyase
ACP_RS14395	COG0076	glutamate decarboxylase activity
ACP_RS14425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACP_RS14435	COG0477	Major facilitator Superfamily
ACP_RS14450	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ACP_RS14470	COG0450	alkyl hydroperoxide reductase
ACP_RS14475	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACP_RS14480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACP_RS14485	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACP_RS14490	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ACP_RS14500	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ACP_RS14505	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
ACP_RS14510	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ACP_RS14515	COG0375	protein maturation
ACP_RS14520	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ACP_RS14535	COG0298	carbon dioxide binding
ACP_RS14540	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ACP_RS14550	COG2814	Major facilitator Superfamily
ACP_RS14570	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ACP_RS14580	COG0488	(ABC) transporter
ACP_RS14610	COG1846	Transcriptional regulator
ACP_RS14620	COG1741	Belongs to the pirin family
ACP_RS14635	COG0254	rRNA binding
ACP_RS14640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACP_RS14665	COG0028	Belongs to the TPP enzyme family
ACP_RS14690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACP_RS14695	COG0137	argininosuccinate synthase activity
ACP_RS14700	COG2755	lipolytic protein G-D-S-L family
ACP_RS14705	COG1309	transcriptional regulator
ACP_RS14710	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ACP_RS14765	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACP_RS14770	COG1459	type II secretion system
ACP_RS14790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACP_RS14795	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ACP_RS14800	COG1278	Cold shock
ACP_RS14805	COG1295	ribonuclease BN
ACP_RS14810	COG2770	Histidine kinase
ACP_RS14810	COG2208	phosphoserine phosphatase activity
ACP_RS14825	COG0793	Belongs to the peptidase S41A family
ACP_RS14835	COG3481	metal-dependent phosphohydrolase, HD sub domain
ACP_RS14845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACP_RS14850	COG0242	peptide deformylase activity
ACP_RS14855	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACP_RS14860	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ACP_RS14860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACP_RS14875	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ACP_RS14880	COG2226	methyltransferase
ACP_RS14885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACP_RS14890	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ACP_RS14895	COG1335	isochorismatase
ACP_RS14900	COG3384	dioxygenase
ACP_RS14930	COG0805	protein transport
ACP_RS14940	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ACP_RS14960	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ACP_RS14970	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACP_RS14990	COG0022	dehydrogenase e1 component
ACP_RS14995	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ACP_RS15000	COG0668	transmembrane transport
ACP_RS15005	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACP_RS15005	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ACP_RS15010	COG0802	atpase or kinase
ACP_RS15015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ACP_RS15025	COG0582	viral genome integration into host DNA
ACP_RS15030	COG0583	DNA-binding transcription factor activity
ACP_RS15045	COG3451	type IV secretory pathway VirB4
ACP_RS15080	COG1396	sequence-specific DNA binding
ACP_RS15090	COG4962	Type ii secretion system protein e
ACP_RS15095	COG0629	single-stranded DNA binding
ACP_RS15140	COG1104	cysteine desulfurase activity
ACP_RS15185	COG1475	DNA binding
ACP_RS15200	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACP_RS15280	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
ACP_RS15295	COG0577	efflux transmembrane transporter activity
ACP_RS15300	COG3344	reverse transcriptase
ACP_RS15335	COG0367	asparagine synthase
ACP_RS15480	COG0210	DNA helicase
ACP_RS15525	COG4962	Type ii secretion system protein e
ACP_RS15565	COG3451	type IV secretory pathway VirB4
ACP_RS15625	COG1569	PIN domain
ACP_RS15630	COG3311	Transcriptional regulator
ACP_RS15635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACP_RS15670	COG0738	Major facilitator superfamily
ACP_RS15675	COG1063	alcohol dehydrogenase
ACP_RS15695	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACP_RS15700	COG2721	sulfolactate sulfo-lyase activity
ACP_RS15705	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_RS15710	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_RS15720	COG1305	Transglutaminase-like
ACP_RS15730	COG2308	Evidence 4 Homologs of previously reported genes of
ACP_RS15740	COG0590	tRNA wobble adenosine to inosine editing
ACP_RS15755	COG0138	bifunctional purine biosynthesis protein purh
ACP_RS15765	COG1476	TRANSCRIPTIONal
ACP_RS15770	COG0412	Dienelactone hydrolase
ACP_RS15785	COG3548	integral membrane protein
ACP_RS15790	COG3361	conserved protein (COG2071)
ACP_RS15800	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACP_RS15805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACP_RS15815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACP_RS15820	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ACP_RS15830	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACP_RS15835	COG0517	IMP dehydrogenase activity
ACP_RS15835	COG0516	GMP reductase activity
ACP_RS15840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACP_RS15850	COG3186	Phenylalanine-4-hydroxylase
ACP_RS15855	COG1733	regulation of RNA biosynthetic process
ACP_RS15860	COG0702	epimerase
ACP_RS15870	COG2272	Belongs to the type-B carboxylesterase lipase family
ACP_RS15885	COG0779	Required for maturation of 30S ribosomal subunits
ACP_RS15890	COG0195	Participates in both transcription termination and antitermination
ACP_RS15895	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACP_RS15905	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACP_RS15910	COG1657	PFAM Prenyltransferase squalene oxidase
ACP_RS15930	COG0717	Belongs to the dCTP deaminase family
ACP_RS15940	COG1410	methionine synthase
ACP_RS15940	COG0646	methionine synthase
ACP_RS15950	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACP_RS15950	COG1648	precorrin-2 dehydrogenase activity
ACP_RS15955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACP_RS15980	COG3409	Peptidoglycan-binding domain 1 protein
ACP_RS15980	COG0793	Belongs to the peptidase S41A family
ACP_RS15985	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ACP_RS15995	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACP_RS15995	COG2755	lipolytic protein G-D-S-L family
ACP_RS16010	COG1393	Belongs to the ArsC family
ACP_RS16015	COG0196	riboflavin kinase activity
ACP_RS16020	COG0321	lipoyl(octanoyl) transferase activity
ACP_RS16020	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ACP_RS16030	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACP_RS16040	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ACP_RS16065	COG1619	proteins homologs of microcin C7 resistance protein MccF
ACP_RS16070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACP_RS16090	COG0330	HflC and HflK could
ACP_RS16095	COG1030	water channel activity
ACP_RS16120	COG0492	ferredoxin-NADP+ reductase activity
ACP_RS16200	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ACP_RS16225	COG0756	dUTP diphosphatase activity
ACP_RS16235	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_RS16275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACP_RS16295	COG1546	Belongs to the CinA family
ACP_RS16295	COG1058	Belongs to the CinA family
ACP_RS16300	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ACP_RS16305	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACP_RS16315	COG0552	protein localization to endoplasmic reticulum
ACP_RS16320	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACP_RS16320	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACP_RS16340	COG0758	DNA mediated transformation
ACP_RS16345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ACP_RS16350	COG3077	Addiction module antitoxin, RelB DinJ family
ACP_RS16380	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
ACP_RS16415	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACP_RS16420	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACP_RS16425	COG0740	serine-type endopeptidase activity
ACP_RS16430	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACP_RS16435	COG3263	regulation of cellular component size
ACP_RS16440	COG2814	Major facilitator Superfamily
ACP_RS16450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ACP_RS16455	COG0640	Transcriptional regulator
ACP_RS16465	COG0798	PFAM Bile acid sodium symporter
ACP_RS16480	COG0248	Ppx GppA phosphatase
ACP_RS16485	COG2062	phosphohistidine phosphatase, SixA
ACP_RS16490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACP_RS16495	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ACP_RS16510	COG1566	PFAM secretion protein HlyD family protein
ACP_RS16515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACP_RS16525	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACP_RS16530	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACP_RS16540	COG1560	Kdo2-lipid A biosynthetic process
ACP_RS16545	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACP_RS16555	COG2249	NAD(P)H dehydrogenase (quinone) activity
ACP_RS16560	COG3852	Histidine kinase
ACP_RS16570	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ACP_RS16575	COG0440	acetolactate synthase activity
ACP_RS16580	COG0028	Belongs to the TPP enzyme family
ACP_RS16585	COG0129	dihydroxy-acid dehydratase activity
ACP_RS16590	COG0066	3-isopropylmalate dehydratase activity
ACP_RS16595	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ACP_RS16600	COG0473	3-isopropylmalate dehydrogenase activity
ACP_RS16605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACP_RS16610	COG0583	DNA-binding transcription factor activity
ACP_RS16645	COG1193	negative regulation of DNA recombination
ACP_RS16650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACP_RS16660	COG1012	belongs to the aldehyde dehydrogenase family
ACP_RS16685	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACP_RS16705	COG1132	(ABC) transporter
ACP_RS16710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACP_RS16735	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACP_RS16770	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ACP_RS16815	COG1136	(ABC) transporter
ACP_RS16815	COG0577	efflux transmembrane transporter activity
ACP_RS16825	COG1505	serine-type exopeptidase activity
ACP_RS16835	COG0531	amino acid
ACP_RS16845	COG4774	siderophore transport
ACP_RS16850	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ACP_RS16885	COG0741	lytic transglycosylase activity
ACP_RS16905	COG2197	response regulator
ACP_RS16945	COG5654	RES domain protein
ACP_RS16950	COG0746	molybdenum cofactor guanylyltransferase activity
ACP_RS16955	COG1127	ABC transporter
ACP_RS17030	COG1621	beta-fructofuranosidase activity
ACP_RS17040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACP_RS17045	COG3706	GGDEF domain
ACP_RS17045	COG4251	negative regulation of phosphorylation
ACP_RS17045	COG5001	Diguanylate cyclase
ACP_RS17045	COG2203	Gaf domain
ACP_RS17060	COG0515	serine threonine protein kinase
ACP_RS17060	COG2815	serine threonine protein kinase
ACP_RS17085	COG2203	Gaf domain
ACP_RS17085	COG3706	GGDEF domain
ACP_RS17085	COG4251	negative regulation of phosphorylation
ACP_RS17085	COG5001	Diguanylate cyclase
ACP_RS17095	COG0784	Response regulator, receiver
ACP_RS17095	COG2205	protein histidine kinase activity
ACP_RS17100	COG3706	GGDEF domain
ACP_RS17100	COG2203	Gaf domain
ACP_RS17100	COG4251	negative regulation of phosphorylation
ACP_RS17100	COG5001	Diguanylate cyclase
ACP_RS17140	COG3300	MHYT domain
ACP_RS17140	COG5001	Diguanylate cyclase
ACP_RS17145	COG2203	Gaf domain
ACP_RS17145	COG2200	EAL domain
ACP_RS17145	COG2199	diguanylate cyclase activity
ACP_RS17155	COG1686	Belongs to the peptidase S11 family
ACP_RS17160	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ACP_RS17175	COG4191	Histidine kinase
ACP_RS17180	COG0840	transmembrane signaling receptor activity
ACP_RS17185	COG1836	PFAM Integral membrane protein DUF92
ACP_RS17190	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ACP_RS17235	COG2198	Histidine kinase
ACP_RS17235	COG0784	Response regulator, receiver
ACP_RS17235	COG5002	protein histidine kinase activity
ACP_RS17260	COG1597	lipid kinase activity
ACP_RS17295	COG5002	protein histidine kinase activity
ACP_RS17300	COG2091	lysine biosynthetic process via aminoadipic acid
ACP_RS17340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACP_RS17375	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACP_RS17380	COG2208	phosphoserine phosphatase activity
ACP_RS17380	COG2770	Histidine kinase
ACP_RS17385	COG3852	Histidine kinase
ACP_RS17390	COG5001	Diguanylate cyclase
ACP_RS17445	COG3064	Membrane
ACP_RS17450	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACP_RS17465	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ACP_RS17480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACP_RS17530	COG2755	lipolytic protein G-D-S-L family
ACP_RS17530	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACP_RS17545	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ACP_RS17560	COG4585	Histidine kinase