locus-tag	class	description
GT370_RS00060	COG1595	DNA-templated transcription, initiation
GT370_RS00085	COG1131	(ABC) transporter
GT370_RS00090	COG0842	Transport permease protein
GT370_RS00095	COG0842	Transport permease protein
GT370_RS00105	COG0798	PFAM Bile acid sodium symporter
GT370_RS00115	COG1393	Belongs to the ArsC family
GT370_RS00175	COG5489	Protein of unknown function (DUF736)
GT370_RS00265	COG0517	IMP dehydrogenase activity
GT370_RS00265	COG0617	tRNA 3'-terminal CCA addition
GT370_RS00265	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GT370_RS00305	COG4566	intracellular signal transduction
GT370_RS00330	COG3039	Transposase
GT370_RS00385	COG0673	inositol 2-dehydrogenase activity
GT370_RS00485	COG1349	DNA-binding transcription factor activity
GT370_RS00490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GT370_RS00495	COG3684	Belongs to the aldolase LacD family
GT370_RS00500	COG1063	alcohol dehydrogenase
GT370_RS00520	COG3046	protein related to deoxyribodipyrimidine photolyase
GT370_RS00525	COG3046	protein related to deoxyribodipyrimidine photolyase
GT370_RS00550	COG0745	RESPONSE REGULATOR receiver
GT370_RS00555	COG4303	Ethanolamine ammonia lyase large subunit
GT370_RS00560	COG4302	ethanolamine ammonia-lyase activity
GT370_RS00565	COG0038	chloride channel
GT370_RS00575	COG0583	DNA-binding transcription factor activity
GT370_RS00600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GT370_RS00605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GT370_RS00610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GT370_RS00615	COG0443	Heat shock 70 kDa protein
GT370_RS00620	COG0484	heat shock protein binding
GT370_RS00650	COG3436	PFAM IS66 Orf2 family protein
GT370_RS00660	COG0625	glutathione transferase activity
GT370_RS00680	COG1959	2 iron, 2 sulfur cluster binding
GT370_RS00685	COG0633	Ferredoxin
GT370_RS00685	COG0543	2 iron, 2 sulfur cluster binding
GT370_RS00695	COG1151	hydroxylamine reductase activity
GT370_RS00700	COG1151	hydroxylamine reductase activity
GT370_RS00725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GT370_RS00735	COG2814	Major facilitator Superfamily
GT370_RS00745	COG0745	RESPONSE REGULATOR receiver
GT370_RS00750	COG0642	Histidine kinase
GT370_RS00755	COG1802	Transcriptional regulator
GT370_RS00770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GT370_RS00775	COG0179	Fumarylacetoacetate (FAA) hydrolase
GT370_RS00795	COG2080	2 iron, 2 sulfur cluster binding
GT370_RS00800	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GT370_RS00805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GT370_RS00810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GT370_RS00825	COG0640	Transcriptional regulator
GT370_RS00830	COG0450	alkyl hydroperoxide reductase
GT370_RS00860	COG0730	response to heat
GT370_RS00890	COG3842	ATPase activity
GT370_RS00895	COG0246	Mannitol dehydrogenase
GT370_RS00905	COG1070	Carbohydrate kinase
GT370_RS00955	COG0246	Mannitol dehydrogenase
GT370_RS00965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GT370_RS00995	COG2072	flavoprotein involved in K transport
GT370_RS01005	COG0656	L-ascorbic acid biosynthetic process
GT370_RS01015	COG3706	GGDEF domain
GT370_RS01020	COG2205	protein histidine kinase activity
GT370_RS01030	COG0477	Major facilitator Superfamily
GT370_RS01035	COG0583	DNA-binding transcription factor activity
GT370_RS01040	COG1028	Short-chain dehydrogenase reductase Sdr
GT370_RS01055	COG1230	cation diffusion facilitator family transporter
GT370_RS01075	COG0481	GTPase activity
GT370_RS01115	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GT370_RS01120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GT370_RS01125	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GT370_RS01135	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
GT370_RS01150	COG2814	Major facilitator Superfamily
GT370_RS01165	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GT370_RS01165	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GT370_RS01200	COG0626	cystathionine gamma-synthase activity
GT370_RS01205	COG2897	thiosulfate sulfurtransferase activity
GT370_RS01215	COG0628	permease
GT370_RS01220	COG0792	nuclease activity
GT370_RS01240	COG0667	Aldo Keto reductase
GT370_RS01255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GT370_RS01260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GT370_RS01275	COG0358	DNA primase activity
GT370_RS01295	COG0564	pseudouridine synthase activity
GT370_RS01330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GT370_RS01335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GT370_RS01345	COG2226	methyltransferase
GT370_RS01355	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GT370_RS01380	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GT370_RS01390	COG0138	bifunctional purine biosynthesis protein purh
GT370_RS01405	COG0438	transferase activity, transferring glycosyl groups
GT370_RS01415	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GT370_RS01435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GT370_RS01445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GT370_RS01445	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GT370_RS01455	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GT370_RS01505	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GT370_RS01510	COG2885	chlorophyll binding
GT370_RS01525	COG0037	tRNA processing
GT370_RS01530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GT370_RS01535	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GT370_RS01540	COG1546	Belongs to the CinA family
GT370_RS01540	COG1058	Belongs to the CinA family
GT370_RS01550	COG0739	heme binding
GT370_RS01550	COG0741	lytic transglycosylase activity
GT370_RS01550	COG1196	nuclear chromosome segregation
GT370_RS01555	COG0741	lytic transglycosylase activity
GT370_RS01560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GT370_RS01565	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GT370_RS01585	COG1758	RNA polymerase activity
GT370_RS01595	COG0736	holo-[acyl-carrier-protein] synthase activity
GT370_RS01625	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GT370_RS01630	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GT370_RS01665	COG3023	N-Acetylmuramoyl-L-alanine amidase
GT370_RS01675	COG2001	Belongs to the MraZ family
GT370_RS01705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GT370_RS01710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GT370_RS01725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GT370_RS01730	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GT370_RS01735	COG1181	Belongs to the D-alanine--D-alanine ligase family
GT370_RS01760	COG0148	phosphopyruvate hydratase activity
GT370_RS01780	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GT370_RS01785	COG0625	glutathione transferase activity
GT370_RS01790	COG0406	alpha-ribazole phosphatase activity
GT370_RS01825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GT370_RS01830	COG1278	Cold shock
GT370_RS01875	COG1192	Involved in chromosome partitioning
GT370_RS01880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GT370_RS01880	COG1648	precorrin-2 dehydrogenase activity
GT370_RS01885	COG0840	transmembrane signaling receptor activity
GT370_RS01900	COG2198	Histidine kinase
GT370_RS01900	COG0643	Histidine kinase
GT370_RS01905	COG2198	Histidine kinase
GT370_RS01905	COG0643	Histidine kinase
GT370_RS01910	COG0835	chemotaxis
GT370_RS01915	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GT370_RS01920	COG2201	protein-glutamate methylesterase activity
GT370_RS01925	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GT370_RS01935	COG0835	chemotaxis
GT370_RS01940	COG2945	thiolester hydrolase activity
GT370_RS01945	COG1045	serine acetyltransferase
GT370_RS01970	COG4178	(ABC) transporter
GT370_RS02000	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GT370_RS02005	COG0271	Belongs to the BolA IbaG family
GT370_RS02010	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GT370_RS02015	COG0047	phosphoribosylformylglycinamidine synthase activity
GT370_RS02020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GT370_RS02030	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GT370_RS02035	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GT370_RS02065	COG1509	lysine 2,3-aminomutase activity
GT370_RS02070	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GT370_RS02090	COG1830	Aldolase
GT370_RS02115	COG0776	regulation of translation
GT370_RS02130	COG0135	phosphoribosylanthranilate isomerase activity
GT370_RS02135	COG0730	response to heat
GT370_RS02145	COG4974	Belongs to the 'phage' integrase family
GT370_RS02150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GT370_RS02185	COG1686	Belongs to the peptidase S11 family
GT370_RS02205	COG2824	Alkylphosphonate utilization operon protein PhnA
GT370_RS02225	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GT370_RS02225	COG2010	Cytochrome c
GT370_RS02240	COG0457	Tetratricopeptide repeat
GT370_RS02255	COG5265	(ABC) transporter
GT370_RS02260	COG0521	Mo-molybdopterin cofactor biosynthetic process
GT370_RS02265	COG0741	lytic transglycosylase activity
GT370_RS02275	COG1573	uracil-dna glycosylase
GT370_RS02300	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GT370_RS02305	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GT370_RS02320	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GT370_RS02325	COG1846	Transcriptional regulator
GT370_RS02345	COG0756	dUTP diphosphatase activity
GT370_RS02350	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GT370_RS02355	COG2226	methyltransferase
GT370_RS02375	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GT370_RS02380	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GT370_RS02385	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GT370_RS02410	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GT370_RS02440	COG1923	regulation of RNA biosynthetic process
GT370_RS02450	COG0483	inositol monophosphate 1-phosphatase activity
GT370_RS02465	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GT370_RS02490	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GT370_RS02540	COG0596	Alpha beta hydrolase
GT370_RS02550	COG0745	RESPONSE REGULATOR receiver
GT370_RS02555	COG0745	RESPONSE REGULATOR receiver
GT370_RS02565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GT370_RS02580	COG3240	lipase activity
GT370_RS02585	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GT370_RS02605	COG0019	diaminopimelate decarboxylase activity
GT370_RS02615	COG0165	Argininosuccinate lyase
GT370_RS02620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GT370_RS02640	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GT370_RS02670	COG0556	nucleotide-excision repair
GT370_RS02680	COG2116	formate transmembrane transporter activity
GT370_RS02695	COG0837	glucose binding
GT370_RS02700	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GT370_RS02750	COG4191	Histidine kinase
GT370_RS02750	COG0784	Response regulator, receiver
GT370_RS02760	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GT370_RS02765	COG0509	glycine decarboxylation via glycine cleavage system
GT370_RS02775	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GT370_RS02785	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GT370_RS02815	COG0829	nickel cation binding
GT370_RS02820	COG0804	urea catabolic process
GT370_RS02825	COG0832	Belongs to the urease beta subunit family
GT370_RS02825	COG0831	urea catabolic process
GT370_RS02830	COG0830	nickel cation binding
GT370_RS02840	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
GT370_RS02845	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GT370_RS02865	COG0159	tryptophan synthase activity
GT370_RS02870	COG0133	tryptophan synthase activity
GT370_RS02880	COG0473	3-isopropylmalate dehydrogenase activity
GT370_RS02910	COG0492	ferredoxin-NADP+ reductase activity
GT370_RS02920	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GT370_RS02930	COG2887	Belongs to the helicase family. UvrD subfamily
GT370_RS02935	COG1074	ATP-dependent DNA helicase activity
GT370_RS02965	COG1522	sequence-specific DNA binding
GT370_RS02995	COG1304	FMN binding
GT370_RS03000	COG4213	ABC transporter substrate-binding protein
GT370_RS03020	COG4214	carbohydrate transport
GT370_RS03035	COG1940	carbohydrate kinase activity
GT370_RS03045	COG0363	glucosamine-6-phosphate deaminase activity
GT370_RS03050	COG0129	dihydroxy-acid dehydratase activity
GT370_RS03055	COG0800	Aldolase
GT370_RS03065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GT370_RS03075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GT370_RS03100	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GT370_RS03105	COG1845	cytochrome c oxidase, subunit III
GT370_RS03120	COG1960	acyl-CoA dehydrogenase activity
GT370_RS03130	COG0183	Belongs to the thiolase family
GT370_RS03165	COG0318	PFAM AMP-dependent synthetase and ligase
GT370_RS03200	COG0493	'glutamate synthase
GT370_RS03200	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GT370_RS03220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GT370_RS03225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GT370_RS03235	COG1309	transcriptional regulator
GT370_RS03240	COG1024	Enoyl-CoA hydratase
GT370_RS03245	COG1024	Enoyl-CoA hydratase
GT370_RS03285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GT370_RS03290	COG2154	pterin-4-alpha-carbinolamine dehydratase
GT370_RS03320	COG0483	inositol monophosphate 1-phosphatase activity
GT370_RS03340	COG0829	nickel cation binding
GT370_RS03345	COG0831	urea catabolic process
GT370_RS03350	COG0832	Belongs to the urease beta subunit family
GT370_RS03365	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GT370_RS03385	COG4106	trans-aconitate 2-methyltransferase activity
GT370_RS03395	COG3842	ATPase activity
GT370_RS03405	COG0395	ABC-type sugar transport system, permease component
GT370_RS03415	COG1176	ABC-type spermidine putrescine transport system, permease component I
GT370_RS03420	COG1176	ABC-type spermidine putrescine transport system, permease component I
GT370_RS03435	COG2186	Transcriptional regulator
GT370_RS03445	COG2267	carboxylic ester hydrolase activity
GT370_RS03455	COG1012	belongs to the aldehyde dehydrogenase family
GT370_RS03470	COG1024	Enoyl-CoA hydratase
GT370_RS03475	COG1024	Enoyl-CoA hydratase
GT370_RS03520	COG1137	ATPase activity
GT370_RS03535	COG4214	carbohydrate transport
GT370_RS03565	COG2186	Transcriptional regulator
GT370_RS03575	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GT370_RS03580	COG0679	Auxin Efflux Carrier
GT370_RS03590	COG2226	methyltransferase
GT370_RS03600	COG3008	intermembrane lipid transfer
GT370_RS03605	COG2995	paraquat-inducible protein a
GT370_RS03620	COG0151	Belongs to the GarS family
GT370_RS03630	COG1132	(ABC) transporter
GT370_RS03690	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GT370_RS03700	COG3634	alkyl hydroperoxide reductase activity
GT370_RS03715	COG1686	Belongs to the peptidase S11 family
GT370_RS03720	COG0681	Belongs to the peptidase S26 family
GT370_RS03730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GT370_RS03770	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GT370_RS03775	COG3739	integral membrane protein
GT370_RS03780	COG1185	polyribonucleotide nucleotidyltransferase activity
GT370_RS03785	COG0477	Major facilitator Superfamily
GT370_RS03800	COG1914	H( )-stimulated, divalent metal cation uptake system
GT370_RS03805	COG1914	H( )-stimulated, divalent metal cation uptake system
GT370_RS03815	COG3956	TIGRFAM MazG family protein
GT370_RS03820	COG0386	Belongs to the glutathione peroxidase family
GT370_RS03845	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GT370_RS03850	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GT370_RS03880	COG3088	subunit of a heme lyase
GT370_RS03890	COG1138	Cytochrome C-type biogenesis protein
GT370_RS03895	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GT370_RS03905	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GT370_RS03930	COG4221	oxidoreductase activity
GT370_RS03945	COG0698	ribose 5-phosphate isomerase
GT370_RS03950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GT370_RS03955	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GT370_RS03960	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GT370_RS03960	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GT370_RS03975	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GT370_RS03980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GT370_RS03985	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GT370_RS03995	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GT370_RS04000	COG0793	Belongs to the peptidase S41A family
GT370_RS04010	COG0557	exoribonuclease II activity
GT370_RS04025	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GT370_RS04045	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GT370_RS04055	COG0259	pyridoxamine-phosphate oxidase activity
GT370_RS04060	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GT370_RS04080	COG5002	protein histidine kinase activity
GT370_RS04085	COG0069	glutamate synthase activity
GT370_RS04095	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GT370_RS04120	COG1442	glycosyl transferase family 8
GT370_RS04155	COG1959	2 iron, 2 sulfur cluster binding
GT370_RS04165	COG1538	Outer membrane efflux protein
GT370_RS04200	COG0438	transferase activity, transferring glycosyl groups
GT370_RS04205	COG0859	PFAM glycosyl transferase family 9
GT370_RS04230	COG0415	Belongs to the DNA photolyase family
GT370_RS04265	COG1960	acyl-CoA dehydrogenase activity
GT370_RS04270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GT370_RS04285	COG3842	ATPase activity
GT370_RS04330	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GT370_RS04340	COG0540	Belongs to the ATCase OTCase family
GT370_RS04360	COG0084	hydrolase, TatD family'
GT370_RS04365	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GT370_RS04375	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GT370_RS04385	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GT370_RS04400	COG2983	Belongs to the UPF0260 family
GT370_RS04420	COG3706	GGDEF domain
GT370_RS04440	COG0069	glutamate synthase activity
GT370_RS04445	COG2218	PFAM glutamate synthase alpha subunit domain protein
GT370_RS04450	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GT370_RS04455	COG1064	alcohol dehydrogenase
GT370_RS04465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GT370_RS04475	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GT370_RS04480	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GT370_RS04505	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GT370_RS04515	COG0194	GDP metabolic process
GT370_RS04520	COG1561	YicC-like family, N-terminal region
GT370_RS04580	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GT370_RS04630	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GT370_RS04635	COG2814	Major facilitator Superfamily
GT370_RS04640	COG0131	Imidazoleglycerol-phosphate dehydratase
GT370_RS04645	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GT370_RS04655	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GT370_RS04660	COG0107	imidazoleglycerol-phosphate synthase activity
GT370_RS04665	COG0140	phosphoribosyl-ATP diphosphatase activity
GT370_RS04705	COG2353	YceI-like domain
GT370_RS04745	COG1266	CAAX protease self-immunity
GT370_RS04750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GT370_RS04755	COG0235	Class ii aldolase
GT370_RS04765	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
GT370_RS04770	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GT370_RS04775	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GT370_RS04780	COG1396	sequence-specific DNA binding
GT370_RS04860	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GT370_RS04865	COG2084	Dehydrogenase
GT370_RS04880	COG0776	regulation of translation
GT370_RS04885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GT370_RS04890	COG0416	fatty acid biosynthetic process
GT370_RS04895	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GT370_RS04975	COG1137	ATPase activity
GT370_RS04985	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GT370_RS04990	COG0024	Methionine aminopeptidase
GT370_RS04995	COG0114	fumarate hydratase activity
GT370_RS05025	COG3594	Acyltransferase
GT370_RS05050	COG0658	competence protein
GT370_RS05050	COG2333	competence protein COMEC
GT370_RS05110	COG4964	Belongs to the GSP D family
GT370_RS05195	COG0477	Major facilitator Superfamily
GT370_RS05215	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
GT370_RS05220	COG1028	Short-chain dehydrogenase reductase Sdr
GT370_RS05225	COG3734	2-keto-3-deoxy-galactonokinase
GT370_RS05230	COG0800	Aldolase
GT370_RS05235	COG0800	Aldolase
GT370_RS05295	COG2031	fatty acid transporter
GT370_RS05300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GT370_RS05300	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GT370_RS05305	COG1105	Belongs to the carbohydrate kinase PfkB family
GT370_RS05310	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GT370_RS05310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GT370_RS05320	COG0038	chloride channel
GT370_RS05340	COG3383	formate dehydrogenase (NAD+) activity
GT370_RS05370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GT370_RS05385	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GT370_RS05385	COG0519	Catalyzes the synthesis of GMP from XMP
GT370_RS05395	COG3328	transposase activity
GT370_RS05440	COG3846	protein secretion by the type IV secretion system
GT370_RS05445	COG5314	conjugation
GT370_RS05470	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GT370_RS05520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GT370_RS05530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GT370_RS05535	COG2171	N-acyltransferase activity
GT370_RS05540	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GT370_RS05550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GT370_RS05555	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
GT370_RS05570	COG1994	Peptidase M50
GT370_RS05575	COG1472	Belongs to the glycosyl hydrolase 3 family
GT370_RS05590	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GT370_RS05605	COG0316	Belongs to the HesB IscA family
GT370_RS05610	COG2151	metal-sulfur cluster biosynthetic enzyme
GT370_RS05620	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GT370_RS05625	COG0719	Fe-S assembly protein
GT370_RS05635	COG0396	ATPase activity
GT370_RS05640	COG0719	Fe-S assembly protein
GT370_RS05645	COG1959	2 iron, 2 sulfur cluster binding
GT370_RS05655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GT370_RS05670	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GT370_RS05680	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GT370_RS05695	COG1695	Transcriptional regulator
GT370_RS05720	COG1519	Transferase
GT370_RS05725	COG1519	Transferase
GT370_RS05770	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GT370_RS05775	COG3040	lipid binding
GT370_RS05820	COG2339	peptidase activity
GT370_RS05830	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GT370_RS05840	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GT370_RS05855	COG1131	(ABC) transporter
GT370_RS05885	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GT370_RS05920	COG3617	BRO family, N-terminal domain
GT370_RS06010	COG1216	Glycosyl transferase, family 2
GT370_RS06010	COG0463	Glycosyl transferase, family 2
GT370_RS06020	COG0598	Magnesium transport protein CorA
GT370_RS06045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GT370_RS06050	COG1381	Involved in DNA repair and RecF pathway recombination
GT370_RS06060	COG1473	amidohydrolase
GT370_RS06065	COG1473	amidohydrolase
GT370_RS06075	COG0527	aspartate kinase activity
GT370_RS06105	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GT370_RS06110	COG2890	protein-(glutamine-N5) methyltransferase activity
GT370_RS06130	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GT370_RS06165	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GT370_RS06215	COG0321	lipoyl(octanoyl) transferase activity
GT370_RS06230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GT370_RS06235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GT370_RS06255	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GT370_RS06275	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GT370_RS06295	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GT370_RS06300	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GT370_RS06305	COG3706	GGDEF domain
GT370_RS06305	COG2203	Gaf domain
GT370_RS06305	COG4251	negative regulation of phosphorylation
GT370_RS06305	COG5001	Diguanylate cyclase
GT370_RS06330	COG2733	membrane
GT370_RS06335	COG2733	membrane
GT370_RS06360	COG0582	viral genome integration into host DNA
GT370_RS06440	COG2963	transposase activity
GT370_RS06445	COG3436	PFAM IS66 Orf2 family protein
GT370_RS06450	COG2433	Pfam Transposase IS66
GT370_RS06455	COG3318	Belongs to the UPF0149 family
GT370_RS06480	COG2814	Major facilitator Superfamily
GT370_RS06495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GT370_RS06550	COG0346	lactoylglutathione lyase activity
GT370_RS06565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GT370_RS06585	COG0750	zinc metalloprotease
GT370_RS06590	COG0750	zinc metalloprotease
GT370_RS06605	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GT370_RS06610	COG0233	cytoplasmic translational termination
GT370_RS06615	COG0528	UMP kinase activity
GT370_RS06640	COG0823	Involved in the tonB-independent uptake of proteins
GT370_RS06675	COG0811	peptide transport
GT370_RS06680	COG0824	Thioesterase
GT370_RS06695	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GT370_RS06700	COG0217	transcriptional regulatory protein
GT370_RS06705	COG4191	Histidine kinase
GT370_RS06705	COG0784	Response regulator, receiver
GT370_RS06720	COG4133	protoheme IX ABC transporter activity
GT370_RS06725	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GT370_RS06730	COG0517	IMP dehydrogenase activity
GT370_RS06735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GT370_RS06750	COG2814	Major facilitator Superfamily
GT370_RS06765	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GT370_RS06775	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GT370_RS06780	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
GT370_RS06795	COG0583	DNA-binding transcription factor activity
GT370_RS06800	COG1546	Belongs to the CinA family
GT370_RS06800	COG1058	Belongs to the CinA family
GT370_RS06805	COG0494	nUDIX hydrolase
GT370_RS06810	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GT370_RS06815	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GT370_RS06820	COG0799	negative regulation of ribosome biogenesis
GT370_RS06825	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GT370_RS06835	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GT370_RS06845	COG0793	Belongs to the peptidase S41A family
GT370_RS06850	COG1051	belongs to the nudix hydrolase family
GT370_RS06855	COG0412	Dienelactone hydrolase
GT370_RS06875	COG0776	regulation of translation
GT370_RS06910	COG0513	Belongs to the DEAD box helicase family
GT370_RS06920	COG1253	flavin adenine dinucleotide binding
GT370_RS06925	COG0154	amidase activity
GT370_RS06945	COG0668	transmembrane transport
GT370_RS06950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GT370_RS06960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GT370_RS06970	COG0513	Belongs to the DEAD box helicase family
GT370_RS06975	COG0789	Transcriptional regulator
GT370_RS06980	COG2217	Heavy metal translocating P-type atpase
GT370_RS07005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GT370_RS07020	COG0175	sulfate reduction
GT370_RS07030	COG2205	protein histidine kinase activity
GT370_RS07040	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GT370_RS07045	COG0594	ribonuclease P activity
GT370_RS07050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GT370_RS07065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GT370_RS07075	COG1392	Phosphate transport regulator
GT370_RS07080	COG2828	Protein conserved in bacteria
GT370_RS07095	COG1802	Transcriptional regulator
GT370_RS07105	COG3842	ATPase activity
GT370_RS07115	COG4208	sulfate ABC transporter
GT370_RS07130	COG1309	transcriptional regulator
GT370_RS07135	COG1335	isochorismatase
GT370_RS07335	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GT370_RS07340	COG3750	Belongs to the UPF0335 family
GT370_RS07505	COG2814	Major facilitator Superfamily
GT370_RS07520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GT370_RS07525	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GT370_RS07530	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GT370_RS07535	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GT370_RS07540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GT370_RS07550	COG0477	Major facilitator Superfamily
GT370_RS07580	COG0583	DNA-binding transcription factor activity
GT370_RS07605	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GT370_RS07610	COG1420	regulation of RNA biosynthetic process
GT370_RS07630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GT370_RS07635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GT370_RS07640	COG0174	glutamine synthetase
GT370_RS07650	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GT370_RS07655	COG1177	transmembrane transport
GT370_RS07665	COG3842	ATPase activity
GT370_RS07670	COG1396	sequence-specific DNA binding
GT370_RS07670	COG1917	Cupin 2, conserved barrel domain protein
GT370_RS07685	COG1832	CoA-binding protein
GT370_RS07690	COG1716	ATPase activity
GT370_RS07690	COG5001	Diguanylate cyclase
GT370_RS07735	COG0308	aminopeptidase N
GT370_RS07740	COG0625	glutathione transferase activity
GT370_RS07790	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GT370_RS07845	COG0457	Tetratricopeptide repeat
GT370_RS07860	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GT370_RS07870	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GT370_RS07900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GT370_RS07910	COG0515	serine threonine protein kinase
GT370_RS07910	COG2815	serine threonine protein kinase
GT370_RS07935	COG0347	Belongs to the P(II) protein family
GT370_RS07960	COG2308	Evidence 4 Homologs of previously reported genes of
GT370_RS07970	COG1305	Transglutaminase-like
GT370_RS07980	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GT370_RS07985	COG0564	pseudouridine synthase activity
GT370_RS08045	COG0456	acetyltransferase
GT370_RS08045	COG0454	-acetyltransferase
GT370_RS08085	COG0688	phosphatidylethanolamine metabolic process
GT370_RS08115	COG1028	Short-chain dehydrogenase reductase Sdr
GT370_RS08130	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GT370_RS08135	COG0268	Binds directly to 16S ribosomal RNA
GT370_RS08170	COG2857	Cytochrome c1
GT370_RS08170	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GT370_RS08190	COG0408	coproporphyrinogen oxidase activity
GT370_RS08205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GT370_RS08210	COG0022	dehydrogenase e1 component
GT370_RS08210	COG0508	dehydrogenase complex catalyzes the overall conversion of
GT370_RS08215	COG0508	dehydrogenase complex catalyzes the overall conversion of
GT370_RS08225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GT370_RS08230	COG2867	negative regulation of translational initiation
GT370_RS08245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GT370_RS08250	COG0629	single-stranded DNA binding
GT370_RS08265	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GT370_RS08275	COG0583	DNA-binding transcription factor activity
GT370_RS08285	COG0235	Class ii aldolase
GT370_RS08295	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GT370_RS08300	COG2986	histidine ammonia-lyase
GT370_RS08305	COG1228	amidohydrolase
GT370_RS08315	COG2188	Transcriptional regulator
GT370_RS08340	COG1566	PFAM secretion protein HlyD family protein
GT370_RS08355	COG5328	Belongs to the UPF0262 family
GT370_RS08365	COG2816	NAD+ diphosphatase activity
GT370_RS08380	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GT370_RS08385	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GT370_RS08420	COG0242	peptide deformylase activity
GT370_RS08425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GT370_RS08430	COG0101	tRNA pseudouridine synthase activity
GT370_RS08455	COG1505	serine-type exopeptidase activity
GT370_RS08460	COG0038	chloride channel
GT370_RS08485	COG0424	maF-like protein
GT370_RS08500	COG0693	protein deglycase activity
GT370_RS08535	COG0004	ammonium transporteR
GT370_RS08540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GT370_RS08560	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GT370_RS08590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GT370_RS08615	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GT370_RS08660	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GT370_RS08665	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GT370_RS08675	COG0392	lysyltransferase activity
GT370_RS08695	COG1217	gtp-binding protein TYPA
GT370_RS08725	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GT370_RS08740	COG1215	transferase activity, transferring glycosyl groups
GT370_RS08745	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GT370_RS08760	COG1716	ATPase activity
GT370_RS08760	COG5001	Diguanylate cyclase
GT370_RS08815	COG0765	amino acid transport
GT370_RS08840	COG4598	ABC transporter
GT370_RS08850	COG0765	amino acid transport
GT370_RS08880	COG1297	OPT oligopeptide transporter protein
GT370_RS08885	COG1297	OPT oligopeptide transporter protein
GT370_RS08900	COG1054	Belongs to the UPF0176 family
GT370_RS08935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GT370_RS08940	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GT370_RS08950	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
GT370_RS08955	COG4251	negative regulation of phosphorylation
GT370_RS08960	COG4191	Histidine kinase
GT370_RS08960	COG0784	Response regulator, receiver
GT370_RS08965	COG4191	Histidine kinase
GT370_RS08965	COG0784	Response regulator, receiver
GT370_RS08985	COG0028	Belongs to the TPP enzyme family
GT370_RS09015	COG3387	PFAM Glycoside hydrolase 15-related
GT370_RS09020	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GT370_RS09025	COG1845	cytochrome c oxidase, subunit III
GT370_RS09030	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GT370_RS09035	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GT370_RS09040	COG0640	Transcriptional regulator
GT370_RS09055	COG2376	Dihydroxyacetone kinase
GT370_RS09070	COG0583	DNA-binding transcription factor activity
GT370_RS09085	COG0667	Aldo Keto reductase
GT370_RS09100	COG3254	rhamnose metabolic process
GT370_RS09105	COG1028	Short-chain dehydrogenase reductase Sdr
GT370_RS09115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GT370_RS09120	COG0246	Mannitol dehydrogenase
GT370_RS09125	COG1063	alcohol dehydrogenase
GT370_RS09130	COG2721	sulfolactate sulfo-lyase activity
GT370_RS09135	COG1129	ABC transporter
GT370_RS09150	COG1172	Belongs to the binding-protein-dependent transport system permease family
GT370_RS09155	COG2186	Transcriptional regulator
GT370_RS09175	COG4974	Belongs to the 'phage' integrase family
GT370_RS09195	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GT370_RS09200	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GT370_RS09255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GT370_RS09280	COG2186	Transcriptional regulator
GT370_RS09285	COG1304	FMN binding
GT370_RS09320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GT370_RS09325	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GT370_RS09330	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GT370_RS09390	COG0488	(ABC) transporter
GT370_RS09405	COG0436	Aminotransferase
GT370_RS09410	COG1764	response to oxidative stress
GT370_RS09420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GT370_RS09435	COG1160	GTP binding
GT370_RS09445	COG0488	(ABC) transporter
GT370_RS09455	COG3842	ATPase activity
GT370_RS09460	COG3842	ATPase activity
GT370_RS09470	COG1177	transmembrane transport
GT370_RS09475	COG3284	Transcriptional regulator
GT370_RS09480	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GT370_RS09480	COG0617	tRNA 3'-terminal CCA addition
GT370_RS09480	COG0517	IMP dehydrogenase activity
GT370_RS09490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GT370_RS09520	COG1045	serine acetyltransferase
GT370_RS09530	COG4191	Histidine kinase
GT370_RS09530	COG0784	Response regulator, receiver
GT370_RS09535	COG0129	dihydroxy-acid dehydratase activity
GT370_RS09540	COG0583	DNA-binding transcription factor activity
GT370_RS09545	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GT370_RS09555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GT370_RS09565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GT370_RS09570	COG0287	Prephenate dehydrogenase
GT370_RS09580	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GT370_RS09610	COG2223	nitrite transmembrane transporter activity
GT370_RS09615	COG2261	transglycosylase associated protein
GT370_RS09640	COG1562	ergosterol biosynthetic process
GT370_RS09645	COG1562	ergosterol biosynthetic process
GT370_RS09665	COG1218	3'(2'),5'-bisphosphate nucleotidase
GT370_RS09675	COG0175	sulfate reduction
GT370_RS09680	COG1028	Short-chain dehydrogenase reductase Sdr
GT370_RS09695	COG0436	Aminotransferase
GT370_RS09700	COG2086	electron transfer activity
GT370_RS09715	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GT370_RS09720	COG0251	oxidation-reduction process
GT370_RS09730	COG3971	2-oxopent-4-enoate hydratase activity
GT370_RS09735	COG3971	2-oxopent-4-enoate hydratase activity
GT370_RS09740	COG0179	Fumarylacetoacetate (FAA) hydrolase
GT370_RS09750	COG0477	Major facilitator Superfamily
GT370_RS09765	COG0583	DNA-binding transcription factor activity
GT370_RS09775	COG3842	ATPase activity
GT370_RS09780	COG1176	ABC-type spermidine putrescine transport system, permease component I
GT370_RS09790	COG1177	transmembrane transport
GT370_RS09845	COG0583	DNA-binding transcription factor activity
GT370_RS09865	COG0583	DNA-binding transcription factor activity
GT370_RS09875	COG3706	GGDEF domain
GT370_RS09875	COG2203	Gaf domain
GT370_RS09875	COG5001	Diguanylate cyclase
GT370_RS09875	COG4251	negative regulation of phosphorylation
GT370_RS09885	COG0702	epimerase
GT370_RS09895	COG0300	oxidoreductase activity
GT370_RS09900	COG0300	oxidoreductase activity
GT370_RS09910	COG1028	Short-chain dehydrogenase reductase Sdr
GT370_RS09950	COG0028	Belongs to the TPP enzyme family
GT370_RS09955	COG3335	DDE superfamily endonuclease
GT370_RS09975	COG3436	PFAM IS66 Orf2 family protein
GT370_RS10030	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GT370_RS10065	COG5489	Protein of unknown function (DUF736)
GT370_RS10085	COG0582	viral genome integration into host DNA
GT370_RS10090	COG0582	viral genome integration into host DNA
GT370_RS10095	COG4974	Belongs to the 'phage' integrase family
GT370_RS10115	COG0789	Transcriptional regulator
GT370_RS10115	COG4978	Transcriptional regulator
GT370_RS10120	COG2814	Major facilitator Superfamily
GT370_RS10150	COG1476	TRANSCRIPTIONal
GT370_RS10155	COG2963	transposase activity
GT370_RS10160	COG3436	PFAM IS66 Orf2 family protein
GT370_RS10165	COG2433	Pfam Transposase IS66
GT370_RS10170	COG3318	Belongs to the UPF0149 family
GT370_RS10205	COG3008	intermembrane lipid transfer
GT370_RS10210	COG2995	paraquat-inducible protein a
GT370_RS10220	COG2203	Gaf domain
GT370_RS10220	COG2199	diguanylate cyclase activity
GT370_RS10220	COG2200	EAL domain
GT370_RS10225	COG3300	MHYT domain
GT370_RS10225	COG5001	Diguanylate cyclase
GT370_RS10245	COG2207	Transcriptional regulator
GT370_RS10255	COG3300	MHYT domain
GT370_RS10255	COG5001	Diguanylate cyclase
GT370_RS10285	COG3318	Belongs to the UPF0149 family
GT370_RS10290	COG2433	Pfam Transposase IS66
GT370_RS10295	COG3436	PFAM IS66 Orf2 family protein
GT370_RS10300	COG2963	transposase activity
GT370_RS10305	COG3300	MHYT domain
GT370_RS10305	COG5001	Diguanylate cyclase
GT370_RS10320	COG1476	TRANSCRIPTIONal
GT370_RS10340	COG2963	transposase activity
GT370_RS10345	COG3436	PFAM IS66 Orf2 family protein
GT370_RS10410	COG0583	DNA-binding transcription factor activity
GT370_RS10415	COG1028	Short-chain dehydrogenase reductase Sdr
GT370_RS10420	COG0508	dehydrogenase complex catalyzes the overall conversion of
GT370_RS10420	COG0596	Alpha beta hydrolase
GT370_RS10425	COG1028	Short-chain dehydrogenase reductase Sdr
GT370_RS10435	COG1028	Short-chain dehydrogenase reductase Sdr
GT370_RS10440	COG5489	Protein of unknown function (DUF736)
GT370_RS10455	COG4974	Belongs to the 'phage' integrase family
GT370_RS10460	COG0582	viral genome integration into host DNA
GT370_RS10465	COG4974	Belongs to the 'phage' integrase family
GT370_RS10500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GT370_RS10545	COG3318	Belongs to the UPF0149 family
GT370_RS10550	COG2433	Pfam Transposase IS66
GT370_RS10555	COG3436	PFAM IS66 Orf2 family protein
GT370_RS10560	COG2963	transposase activity
GT370_RS10580	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GT370_RS10700	COG0463	Glycosyl transferase, family 2
GT370_RS10710	COG2814	Major facilitator Superfamily
GT370_RS10735	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GT370_RS10755	COG0840	transmembrane signaling receptor activity
GT370_RS10765	COG0778	Nitroreductase
GT370_RS10795	COG1012	belongs to the aldehyde dehydrogenase family
GT370_RS10830	COG1522	sequence-specific DNA binding
GT370_RS10835	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GT370_RS10845	COG0366	Alpha amylase catalytic
GT370_RS10860	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GT370_RS10875	COG1640	4-alpha-glucanotransferase
GT370_RS10880	COG1640	4-alpha-glucanotransferase
GT370_RS10905	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GT370_RS10915	COG2271	Major facilitator Superfamily
GT370_RS10920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GT370_RS10925	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GT370_RS10935	COG1393	Belongs to the ArsC family
GT370_RS10940	COG1879	ABC-type sugar transport system periplasmic component
GT370_RS10955	COG1609	Transcriptional regulator
GT370_RS10960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GT370_RS10970	COG2186	Transcriptional regulator
GT370_RS10975	COG1027	Aspartate ammonia-lyase
GT370_RS10980	COG1113	amino acid transport
GT370_RS10985	COG0252	asparaginase activity
GT370_RS10995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GT370_RS11005	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GT370_RS11015	COG0539	negative regulation of cytoplasmic translation
GT370_RS11045	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GT370_RS11050	COG4974	Belongs to the 'phage' integrase family
GT370_RS11060	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GT370_RS11080	COG1696	Membrane protein involved in D-alanine export
GT370_RS11105	COG1116	anion transmembrane transporter activity
GT370_RS11110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GT370_RS11120	COG0203	ribosomal protein L17
GT370_RS11125	COG0202	RNA polymerase activity
GT370_RS11130	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GT370_RS11135	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GT370_RS11140	COG0563	adenylate kinase activity
GT370_RS11150	COG0200	Binds to the 23S rRNA
GT370_RS11155	COG1841	ribosomal large subunit assembly
GT370_RS11160	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GT370_RS11165	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GT370_RS11175	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GT370_RS11180	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GT370_RS11185	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GT370_RS11190	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GT370_RS11195	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GT370_RS11200	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GT370_RS11205	COG0255	Belongs to the universal ribosomal protein uL29 family
GT370_RS11210	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GT370_RS11215	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GT370_RS11220	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GT370_RS11230	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GT370_RS11235	COG0089	rRNA binding
GT370_RS11240	COG0088	Forms part of the polypeptide exit tunnel
GT370_RS11245	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GT370_RS11255	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GT370_RS11260	COG0049	tRNA binding
GT370_RS11265	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GT370_RS11270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GT370_RS11275	COG0085	RNA polymerase activity
GT370_RS11285	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GT370_RS11290	COG0081	regulation of translation
GT370_RS11300	COG1335	isochorismatase
GT370_RS11315	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GT370_RS11325	COG0315	cyclic pyranopterin monophosphate synthase activity
GT370_RS11330	COG0134	indole-3-glycerol-phosphate synthase activity
GT370_RS11360	COG0149	triose-phosphate isomerase activity
GT370_RS11365	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GT370_RS11390	COG4221	oxidoreductase activity
GT370_RS11415	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GT370_RS11420	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GT370_RS11440	COG0305	Participates in initiation and elongation during chromosome replication
GT370_RS11445	COG0045	succinate-CoA ligase (ADP-forming) activity
GT370_RS11445	COG1042	CoA-binding domain protein
GT370_RS11445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GT370_RS11455	COG0360	Binds together with S18 to 16S ribosomal RNA
GT370_RS11460	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GT370_RS11465	COG0359	binds to the 23S rRNA
GT370_RS11475	COG0616	signal peptide processing
GT370_RS11485	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GT370_RS11495	COG0628	permease
GT370_RS11500	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GT370_RS11530	COG1862	Preprotein translocase
GT370_RS11540	COG0142	geranyltranstransferase activity
GT370_RS11580	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GT370_RS11580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GT370_RS11605	COG0477	Major facilitator Superfamily
GT370_RS11615	COG2835	tetraacyldisaccharide 4'-kinase activity
GT370_RS11655	COG0717	Belongs to the dCTP deaminase family
GT370_RS11670	COG2372	response to copper ion
GT370_RS11690	COG0196	riboflavin kinase activity
GT370_RS11705	COG2853	Lipoprotein
GT370_RS11720	COG2264	protein methyltransferase activity
GT370_RS11760	COG3750	Belongs to the UPF0335 family
GT370_RS11770	COG0469	pyruvate kinase activity
GT370_RS11795	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GT370_RS11810	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GT370_RS11820	COG2885	chlorophyll binding
GT370_RS11820	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GT370_RS11830	COG2885	chlorophyll binding
GT370_RS11830	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GT370_RS11860	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GT370_RS11900	COG1136	(ABC) transporter
GT370_RS11910	COG0442	prolyl-tRNA aminoacylation
GT370_RS11930	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GT370_RS11940	COG1007	ATP synthesis coupled electron transport
GT370_RS11955	COG0713	ATP synthesis coupled electron transport
GT370_RS11965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GT370_RS11970	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GT370_RS11985	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GT370_RS11990	COG0649	NAD binding
GT370_RS11995	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GT370_RS12000	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GT370_RS12005	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GT370_RS12020	COG0776	regulation of translation
GT370_RS12030	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GT370_RS12035	COG0740	serine-type endopeptidase activity
GT370_RS12040	COG0544	peptidyl-prolyl cis-trans isomerase activity
GT370_RS12050	COG2982	Protein involved in outer membrane biogenesis
GT370_RS12065	COG1254	Belongs to the acylphosphatase family
GT370_RS12070	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GT370_RS12100	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GT370_RS12100	COG0662	Cupin 2, conserved barrel domain protein
GT370_RS12105	COG2814	Major facilitator Superfamily
GT370_RS12115	COG0484	heat shock protein binding
GT370_RS12135	COG0346	lactoylglutathione lyase activity
GT370_RS12140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GT370_RS12155	COG1396	sequence-specific DNA binding
GT370_RS12155	COG3800	Transcriptional regulator
GT370_RS12165	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GT370_RS12170	COG0735	belongs to the Fur family
GT370_RS12185	COG1121	(ABC) transporter
GT370_RS12195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GT370_RS12220	COG4191	Histidine kinase
GT370_RS12225	COG4566	intracellular signal transduction
GT370_RS12235	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GT370_RS12240	COG0228	four-way junction DNA binding
GT370_RS12245	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GT370_RS12255	COG0335	large ribosomal subunit rRNA binding
GT370_RS12260	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GT370_RS12265	COG0066	3-isopropylmalate dehydratase activity
GT370_RS12310	COG0582	viral genome integration into host DNA
GT370_RS12380	COG0583	DNA-binding transcription factor activity
GT370_RS12385	COG4221	oxidoreductase activity
GT370_RS12395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GT370_RS12395	COG3453	Protein conserved in bacteria
GT370_RS12515	COG3002	Belongs to the UPF0753 family
GT370_RS12525	COG3002	Belongs to the UPF0753 family
GT370_RS12555	COG1741	Belongs to the pirin family
GT370_RS12570	COG3284	Transcriptional regulator
GT370_RS12575	COG1063	alcohol dehydrogenase
GT370_RS12605	COG0028	Belongs to the TPP enzyme family
GT370_RS12615	COG3052	prosthetic group binding
GT370_RS12650	COG0477	Major facilitator Superfamily
GT370_RS12660	COG1053	succinate dehydrogenase
GT370_RS12660	COG3976	FMN-binding domain protein
GT370_RS12665	COG1802	Transcriptional regulator
GT370_RS12690	COG0784	Response regulator, receiver
GT370_RS12695	COG4251	negative regulation of phosphorylation
GT370_RS12745	COG1877	trehalose-phosphatase activity
GT370_RS12750	COG3038	cytochrome b561
GT370_RS12755	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GT370_RS12765	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GT370_RS12775	COG2205	protein histidine kinase activity
GT370_RS12820	COG0277	FAD linked oxidase domain protein
GT370_RS12825	COG0277	FAD linked oxidase domain protein
GT370_RS12845	COG1172	Belongs to the binding-protein-dependent transport system permease family
GT370_RS12855	COG0559	Belongs to the binding-protein-dependent transport system permease family
GT370_RS12865	COG1454	alcohol dehydrogenase
GT370_RS12885	COG0784	Response regulator, receiver
GT370_RS12885	COG2205	protein histidine kinase activity
GT370_RS12885	COG5002	protein histidine kinase activity
GT370_RS12890	COG2205	protein histidine kinase activity
GT370_RS12890	COG3437	response regulator, receiver
GT370_RS12890	COG3850	Histidine kinase
GT370_RS12890	COG4999	Histidine kinase
GT370_RS12895	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GT370_RS12905	COG0784	Response regulator, receiver
GT370_RS12905	COG5002	protein histidine kinase activity
GT370_RS12915	COG2837	iron assimilation
GT370_RS12930	COG2186	Transcriptional regulator
GT370_RS12935	COG3258	Cytochrome c
GT370_RS12940	COG0154	amidase activity
GT370_RS12945	COG0154	amidase activity
GT370_RS12955	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GT370_RS12965	COG2814	Major facilitator Superfamily
GT370_RS12975	COG1309	transcriptional regulator
GT370_RS13020	COG1335	isochorismatase
GT370_RS13060	COG0142	geranyltranstransferase activity
GT370_RS13065	COG1722	exodeoxyribonuclease VII activity
GT370_RS13125	COG1196	nuclear chromosome segregation
GT370_RS13215	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GT370_RS13250	COG0109	protoheme IX farnesyltransferase activity
GT370_RS13270	COG2010	Cytochrome c
GT370_RS13270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GT370_RS13275	COG1565	acr, cog1565
GT370_RS13275	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GT370_RS13280	COG3754	Rhamnan synthesis protein F
GT370_RS13300	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GT370_RS13305	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GT370_RS13315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GT370_RS13380	COG5425	PFAM Usg family protein
GT370_RS13390	COG0459	protein refolding
GT370_RS13405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GT370_RS13425	COG0251	oxidation-reduction process
GT370_RS13495	COG2204	response regulator
GT370_RS13500	COG5002	protein histidine kinase activity
GT370_RS13505	COG0745	RESPONSE REGULATOR receiver
GT370_RS13550	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GT370_RS13575	COG0768	penicillin binding
GT370_RS13585	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GT370_RS13615	COG0248	Ppx GppA phosphatase
GT370_RS13635	COG0778	Nitroreductase
GT370_RS13640	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GT370_RS13675	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GT370_RS13710	COG0531	amino acid
GT370_RS13720	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GT370_RS13765	COG1256	bacterial-type flagellum assembly
GT370_RS13765	COG4786	Flagellar basal body rod
GT370_RS13770	COG3951	Flagellar rod assembly protein muramidase FlgJ
GT370_RS13770	COG1705	Flagellar rod assembly protein muramidase FlgJ
GT370_RS13775	COG1706	bacterial-type flagellum-dependent cell motility
GT370_RS13785	COG4786	Flagellar basal body rod
GT370_RS13790	COG4787	bacterial-type flagellum-dependent cell motility
GT370_RS13795	COG1749	Flagellar hook protein flgE
GT370_RS13800	COG4786	Flagellar basal body rod
GT370_RS13815	COG1815	bacterial-type flagellum-dependent cell motility
GT370_RS13825	COG0745	RESPONSE REGULATOR receiver
GT370_RS13830	COG1677	Flagellar hook-basal body complex protein FliE
GT370_RS13845	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GT370_RS13865	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GT370_RS13870	COG1191	sigma factor activity
GT370_RS13875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GT370_RS13880	COG1360	Flagellar Motor Protein
GT370_RS13955	COG0254	rRNA binding
GT370_RS13970	COG1346	cytolysis
GT370_RS13990	COG1028	Short-chain dehydrogenase reductase Sdr
GT370_RS13995	COG3546	catalase activity
GT370_RS14000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GT370_RS14005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GT370_RS14025	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GT370_RS14040	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GT370_RS14075	COG2982	Protein involved in outer membrane biogenesis
GT370_RS14080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GT370_RS14100	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GT370_RS14145	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GT370_RS14150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GT370_RS14165	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GT370_RS14170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GT370_RS14175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GT370_RS14180	COG1238	metal cluster binding
GT370_RS14185	COG1349	DNA-binding transcription factor activity
GT370_RS14215	COG0105	UTP biosynthetic process
GT370_RS14220	COG0488	(ABC) transporter
GT370_RS14230	COG0628	permease
GT370_RS14240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GT370_RS14245	COG0765	amino acid transport
GT370_RS14315	COG0515	serine threonine protein kinase
GT370_RS14315	COG2815	serine threonine protein kinase
GT370_RS14335	COG2885	chlorophyll binding
GT370_RS14410	COG0631	protein serine/threonine phosphatase activity
GT370_RS14475	COG0596	Alpha beta hydrolase
GT370_RS14475	COG2945	thiolester hydrolase activity
GT370_RS14480	COG0583	DNA-binding transcription factor activity
GT370_RS14485	COG0667	Aldo Keto reductase
GT370_RS14495	COG2207	Transcriptional regulator
GT370_RS14530	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GT370_RS14535	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GT370_RS14545	COG1872	DUF167
GT370_RS14550	COG0583	DNA-binding transcription factor activity
GT370_RS14555	COG0492	ferredoxin-NADP+ reductase activity
GT370_RS14565	COG0251	oxidation-reduction process
GT370_RS14575	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GT370_RS14585	COG0745	RESPONSE REGULATOR receiver
GT370_RS14595	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GT370_RS14600	COG3179	chitinase
GT370_RS14615	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GT370_RS14645	COG0842	Transport permease protein
GT370_RS14650	COG1131	(ABC) transporter
GT370_RS14670	COG2031	fatty acid transporter
GT370_RS14680	COG0395	ABC-type sugar transport system, permease component
GT370_RS14690	COG1028	Short-chain dehydrogenase reductase Sdr
GT370_RS14700	COG3684	Belongs to the aldolase LacD family
GT370_RS14715	COG2186	Transcriptional regulator
GT370_RS14755	COG0511	ligase activity, forming carbon-carbon bonds
GT370_RS14755	COG5016	pyruvate
GT370_RS14775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GT370_RS14820	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GT370_RS14830	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GT370_RS14830	COG1082	Xylose isomerase domain protein TIM barrel
GT370_RS14840	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GT370_RS14850	COG2271	Major facilitator Superfamily
GT370_RS14880	COG0559	Belongs to the binding-protein-dependent transport system permease family
GT370_RS14895	COG1053	succinate dehydrogenase
GT370_RS14905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GT370_RS14920	COG1053	succinate dehydrogenase
GT370_RS14940	COG1414	Transcriptional regulator
GT370_RS14945	COG1414	Transcriptional regulator
GT370_RS14965	COG0583	DNA-binding transcription factor activity
GT370_RS14970	COG2267	carboxylic ester hydrolase activity
GT370_RS14975	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GT370_RS14980	COG3485	protocatechuate 3,4-dioxygenase
GT370_RS14985	COG3485	protocatechuate 3,4-dioxygenase
GT370_RS15020	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GT370_RS15025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GT370_RS15045	COG0587	DNA-directed DNA polymerase activity
GT370_RS15050	COG1476	TRANSCRIPTIONal
GT370_RS15075	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GT370_RS15080	COG0477	Major facilitator Superfamily
GT370_RS15090	COG2814	Major facilitator Superfamily
GT370_RS15105	COG3328	transposase activity
GT370_RS15135	COG2963	transposase activity
GT370_RS15140	COG3436	PFAM IS66 Orf2 family protein
GT370_RS15145	COG2433	Pfam Transposase IS66
GT370_RS15150	COG3318	Belongs to the UPF0149 family
GT370_RS15195	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GT370_RS15225	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GT370_RS15255	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GT370_RS15260	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GT370_RS15460	COG0438	transferase activity, transferring glycosyl groups
GT370_RS15460	COG1216	Glycosyl transferase, family 2
GT370_RS15485	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GT370_RS15500	COG0617	tRNA 3'-terminal CCA addition
GT370_RS15520	COG0357	Ribosomal RNA small subunit methyltransferase G
GT370_RS15535	COG0840	transmembrane signaling receptor activity
GT370_RS15550	COG0495	leucyl-tRNA aminoacylation
GT370_RS15560	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GT370_RS15575	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GT370_RS15580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GT370_RS15585	COG1981	membrane
GT370_RS15590	COG0300	oxidoreductase activity
GT370_RS15595	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GT370_RS15605	COG3243	poly(R)-hydroxyalkanoic acid synthase
GT370_RS15635	COG1028	Short-chain dehydrogenase reductase Sdr
GT370_RS15645	COG0517	IMP dehydrogenase activity
GT370_RS15650	COG1132	(ABC) transporter
GT370_RS15660	COG1918	ferrous iron import across plasma membrane
GT370_RS15660	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GT370_RS15670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GT370_RS15680	COG0193	aminoacyl-tRNA hydrolase activity
GT370_RS15685	COG0012	GTP binding
GT370_RS15705	COG1278	Cold shock
GT370_RS15710	COG3239	Fatty acid desaturase
GT370_RS15720	COG1982	Orn Lys Arg decarboxylase major
GT370_RS15735	COG1294	oxidase, subunit
GT370_RS15740	COG1271	oxidase subunit
GT370_RS15745	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GT370_RS15750	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GT370_RS15755	COG1132	(ABC) transporter
GT370_RS15760	COG4988	ABC transporter
GT370_RS15770	COG2351	hydroxyisourate hydrolase activity
GT370_RS15780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GT370_RS15795	COG2072	flavoprotein involved in K transport
GT370_RS15800	COG2072	flavoprotein involved in K transport
GT370_RS15810	COG1620	l-lactate permease
GT370_RS15845	COG1116	anion transmembrane transporter activity
GT370_RS15850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GT370_RS15870	COG2197	response regulator
GT370_RS15880	COG1132	(ABC) transporter
GT370_RS15885	COG4988	ABC transporter
GT370_RS15890	COG4988	ABC transporter
GT370_RS15900	COG1271	oxidase subunit
GT370_RS15925	COG0784	Response regulator, receiver
GT370_RS15925	COG2198	Histidine kinase
GT370_RS15925	COG5002	protein histidine kinase activity
GT370_RS15985	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GT370_RS15990	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GT370_RS16005	COG1012	belongs to the aldehyde dehydrogenase family
GT370_RS16035	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GT370_RS16040	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
GT370_RS16045	COG0535	radical SAM domain protein
GT370_RS16050	COG0535	radical SAM domain protein
GT370_RS16080	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GT370_RS16095	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GT370_RS16110	COG0612	Peptidase, M16
GT370_RS16115	COG0312	modulator of DNA gyrase
GT370_RS16125	COG1970	mechanosensitive ion channel activity
GT370_RS16145	COG0752	glycyl-tRNA synthetase alpha subunit
GT370_RS16165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GT370_RS16180	COG0668	transmembrane transport
GT370_RS16230	COG0174	glutamine synthetase
GT370_RS16270	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GT370_RS16285	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GT370_RS16290	COG0322	excinuclease ABC activity
GT370_RS16300	COG0745	RESPONSE REGULATOR receiver
GT370_RS16340	COG0590	tRNA wobble adenosine to inosine editing
GT370_RS16350	COG1612	heme a metabolic process
GT370_RS16360	COG0440	acetolactate synthase activity
GT370_RS16365	COG0028	Belongs to the TPP enzyme family
GT370_RS16370	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GT370_RS16375	COG0560	Phosphoserine phosphatase
GT370_RS16375	COG3830	Belongs to the UPF0237 family
GT370_RS16400	COG0424	maF-like protein
GT370_RS16435	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GT370_RS16450	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GT370_RS16480	COG0354	folic acid binding
GT370_RS16485	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GT370_RS16500	COG2814	Major facilitator Superfamily
GT370_RS16520	COG0235	Class ii aldolase
GT370_RS16525	COG1278	Cold shock
GT370_RS16535	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GT370_RS16560	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GT370_RS16575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GT370_RS16585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GT370_RS16590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GT370_RS16600	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GT370_RS16610	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
GT370_RS16675	COG5001	Diguanylate cyclase
GT370_RS16675	COG3300	MHYT domain
GT370_RS16680	COG3300	MHYT domain
GT370_RS16680	COG5001	Diguanylate cyclase
GT370_RS16690	COG0180	Tryptophanyl-tRNA synthetase
GT370_RS16715	COG0745	RESPONSE REGULATOR receiver
GT370_RS16720	COG1846	Transcriptional regulator
GT370_RS16750	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GT370_RS16750	COG0678	peroxiredoxin activity
GT370_RS16770	COG0347	Belongs to the P(II) protein family
GT370_RS16785	COG0746	molybdenum cofactor guanylyltransferase activity
GT370_RS16805	COG0456	acetyltransferase
GT370_RS16855	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GT370_RS16865	COG3813	Protein conserved in bacteria
GT370_RS16880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GT370_RS16895	COG0438	transferase activity, transferring glycosyl groups
GT370_RS16905	COG4953	penicillin-binding protein 1C
GT370_RS16930	COG0657	acetylesterase activity
GT370_RS16930	COG2755	lipolytic protein G-D-S-L family
GT370_RS16965	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GT370_RS16980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GT370_RS17015	COG1253	flavin adenine dinucleotide binding
GT370_RS17020	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GT370_RS17025	COG1702	phosphate starvation-inducible protein PhoH
GT370_RS17030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GT370_RS17045	COG0670	Belongs to the BI1 family
GT370_RS17070	COG3474	cytochrome
GT370_RS17090	COG0328	RNA-DNA hybrid ribonuclease activity
GT370_RS17105	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GT370_RS17115	COG0439	Biotin carboxylase
GT370_RS17135	COG2022	thiamine diphosphate biosynthetic process
GT370_RS17150	COG0237	dephospho-CoA kinase activity
GT370_RS17155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GT370_RS17165	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GT370_RS17185	COG3454	Phosphonate metabolism
GT370_RS17190	COG3454	Phosphonate metabolism
GT370_RS17195	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
GT370_RS17200	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
GT370_RS17210	COG0667	Aldo Keto reductase
GT370_RS17215	COG0667	Aldo Keto reductase
GT370_RS17240	COG3243	poly(R)-hydroxyalkanoic acid synthase
GT370_RS17255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GT370_RS17275	COG0742	ribosomal rna small subunit methyltransferase
GT370_RS17280	COG1187	pseudouridine synthase activity
GT370_RS17285	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GT370_RS17295	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GT370_RS17325	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GT370_RS17330	COG0314	molybdopterin synthase activity
GT370_RS17340	COG1763	Mo-molybdopterin cofactor biosynthetic process
GT370_RS17345	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GT370_RS17350	COG0725	ABC transporter, periplasmic molybdate-binding protein
GT370_RS17365	COG3842	ATPase activity
GT370_RS17375	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GT370_RS17380	COG0045	succinate-CoA ligase (ADP-forming) activity
GT370_RS17385	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GT370_RS17395	COG0508	dehydrogenase complex catalyzes the overall conversion of
GT370_RS17410	COG1597	lipid kinase activity
GT370_RS17420	COG0039	L-malate dehydrogenase activity
GT370_RS17425	COG0651	ATP synthesis coupled electron transport
GT370_RS17470	COG0649	NAD binding
GT370_RS17475	COG0649	NAD binding
GT370_RS17490	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GT370_RS17505	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GT370_RS17510	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GT370_RS17515	COG0343	queuine tRNA-ribosyltransferase activity
GT370_RS17520	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GT370_RS17550	COG0425	Belongs to the sulfur carrier protein TusA family
GT370_RS17555	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GT370_RS17560	COG0242	peptide deformylase activity
GT370_RS17585	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GT370_RS17590	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GT370_RS17605	COG0779	Required for maturation of 30S ribosomal subunits
GT370_RS17610	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GT370_RS17645	COG1028	Short-chain dehydrogenase reductase Sdr
GT370_RS17650	COG0477	Major facilitator Superfamily
GT370_RS17670	COG4977	sequence-specific DNA binding
GT370_RS17680	COG1028	Short-chain dehydrogenase reductase Sdr
GT370_RS17695	COG0243	molybdopterin cofactor binding
GT370_RS17715	COG3008	intermembrane lipid transfer
GT370_RS17740	COG2188	Transcriptional regulator
GT370_RS17745	COG2814	Major facilitator Superfamily
GT370_RS17770	COG3220	belongs to the UPF0276 family
GT370_RS17780	COG1595	DNA-templated transcription, initiation
GT370_RS17790	COG0653	protein targeting
GT370_RS17795	COG3781	membrane
GT370_RS17800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GT370_RS17805	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GT370_RS17810	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GT370_RS17815	COG1999	signal sequence binding
GT370_RS17850	COG1566	PFAM secretion protein HlyD family protein
GT370_RS17890	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GT370_RS17890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GT370_RS17895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GT370_RS17900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GT370_RS17910	COG1660	Displays ATPase and GTPase activities
GT370_RS17925	COG0745	RESPONSE REGULATOR receiver
GT370_RS17945	COG2223	nitrite transmembrane transporter activity
GT370_RS17960	COG0542	response to heat
GT370_RS17965	COG1335	isochorismatase
GT370_RS18020	COG4974	Belongs to the 'phage' integrase family
GT370_RS18035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GT370_RS18050	COG1028	Short-chain dehydrogenase reductase Sdr
GT370_RS18105	COG4974	Belongs to the 'phage' integrase family
GT370_RS18110	COG0582	viral genome integration into host DNA
GT370_RS18115	COG4974	Belongs to the 'phage' integrase family
GT370_RS18140	COG5489	Protein of unknown function (DUF736)
GT370_RS18145	COG0210	DNA helicase
GT370_RS18200	COG3318	Belongs to the UPF0149 family
GT370_RS18205	COG2433	Pfam Transposase IS66
GT370_RS18210	COG3436	PFAM IS66 Orf2 family protein
GT370_RS18215	COG2963	transposase activity
GT370_RS18240	COG0142	geranyltranstransferase activity
GT370_RS18280	COG3093	addiction module antidote protein HigA
GT370_RS18335	COG1024	Enoyl-CoA hydratase
GT370_RS18340	COG0824	Thioesterase
GT370_RS18350	COG2249	NAD(P)H dehydrogenase (quinone) activity
GT370_RS18365	COG1414	Transcriptional regulator
GT370_RS18370	COG3836	Belongs to the HpcH HpaI aldolase family
GT370_RS18375	COG2814	Major facilitator Superfamily
GT370_RS18385	COG3246	L-lysine catabolic process to acetate
GT370_RS18435	COG5002	protein histidine kinase activity
GT370_RS18450	COG2205	protein histidine kinase activity
GT370_RS18455	COG0811	peptide transport
GT370_RS18460	COG0848	biopolymer transport protein
GT370_RS18510	COG5642	Protein of unknown function (DUF2384)
GT370_RS18570	COG1414	Transcriptional regulator
GT370_RS18590	COG1609	Transcriptional regulator
GT370_RS18625	COG3254	rhamnose metabolic process
GT370_RS18640	COG1129	ABC transporter
GT370_RS18655	COG1028	Short-chain dehydrogenase reductase Sdr
GT370_RS18655	COG3347	Dehydrogenase
GT370_RS18665	COG1028	Short-chain dehydrogenase reductase Sdr
GT370_RS18665	COG3347	Dehydrogenase
GT370_RS18670	COG4952	isomerase
GT370_RS18690	COG0583	DNA-binding transcription factor activity
GT370_RS18695	COG0477	Major facilitator Superfamily
GT370_RS18700	COG1024	Enoyl-CoA hydratase
GT370_RS18710	COG1250	3-hydroxyacyl-CoA dehydrogenase
GT370_RS18715	COG1250	3-hydroxyacyl-CoA dehydrogenase
GT370_RS18750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GT370_RS18755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GT370_RS18760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GT370_RS18835	COG1278	Cold shock
GT370_RS18895	COG0642	Histidine kinase
GT370_RS18930	COG0672	)-iron permease
GT370_RS18950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GT370_RS18960	COG0247	lactate metabolic process
GT370_RS18960	COG0277	FAD linked oxidase domain protein
GT370_RS18965	COG0247	lactate metabolic process
GT370_RS18965	COG0277	FAD linked oxidase domain protein
GT370_RS18975	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GT370_RS18985	COG1802	Transcriptional regulator
GT370_RS18990	COG2271	Major facilitator Superfamily
GT370_RS19005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GT370_RS19010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GT370_RS19020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GT370_RS19030	COG1228	amidohydrolase
GT370_RS19065	COG5001	Diguanylate cyclase
GT370_RS19065	COG5002	protein histidine kinase activity
GT370_RS19065	COG3447	MASE1 domain protein
GT370_RS19080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GT370_RS19085	COG0154	amidase activity
GT370_RS19090	COG0154	amidase activity
GT370_RS19100	COG3842	ATPase activity
GT370_RS19105	COG0395	ABC-type sugar transport system, permease component
GT370_RS19115	COG1653	transport
GT370_RS19130	COG0800	Aldolase
GT370_RS19140	COG3265	gluconokinase activity
GT370_RS19145	COG2271	Major facilitator Superfamily
GT370_RS19150	COG2271	Major facilitator Superfamily
GT370_RS19155	COG1609	Transcriptional regulator
GT370_RS19160	COG1609	Transcriptional regulator
GT370_RS19175	COG1741	Belongs to the pirin family
GT370_RS19180	COG0583	DNA-binding transcription factor activity
GT370_RS19185	COG1802	Transcriptional regulator
GT370_RS19190	COG1914	H( )-stimulated, divalent metal cation uptake system
GT370_RS19195	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GT370_RS19205	COG4336	lyase activity
GT370_RS19215	COG4770	biotin carboxylase activity
GT370_RS19225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GT370_RS19235	COG1595	DNA-templated transcription, initiation
GT370_RS19250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GT370_RS19265	COG3300	MHYT domain
GT370_RS19265	COG5001	Diguanylate cyclase
GT370_RS19270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GT370_RS19275	COG1028	Short-chain dehydrogenase reductase Sdr
GT370_RS19330	COG0811	peptide transport
GT370_RS19355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GT370_RS19370	COG1132	(ABC) transporter
GT370_RS19405	COG0531	amino acid
GT370_RS19440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GT370_RS19455	COG1737	Transcriptional regulator
GT370_RS19460	COG1116	anion transmembrane transporter activity
GT370_RS19465	COG0390	transport system, permease component
GT370_RS19475	COG0811	peptide transport
GT370_RS19480	COG0848	biopolymer transport protein
GT370_RS19505	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GT370_RS19510	COG3842	ATPase activity
GT370_RS19520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GT370_RS19530	COG0154	amidase activity
GT370_RS19550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GT370_RS19555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GT370_RS19560	COG1349	DNA-binding transcription factor activity
GT370_RS19565	COG0154	amidase activity
GT370_RS19650	COG1116	anion transmembrane transporter activity
GT370_RS19650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GT370_RS19660	COG2223	nitrite transmembrane transporter activity
GT370_RS19665	COG2223	nitrite transmembrane transporter activity
GT370_RS19670	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GT370_RS19680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GT370_RS19680	COG1648	precorrin-2 dehydrogenase activity
GT370_RS19685	COG0243	molybdopterin cofactor binding
GT370_RS19695	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GT370_RS19715	COG2198	Histidine kinase
GT370_RS19715	COG2205	protein histidine kinase activity
GT370_RS19715	COG0784	Response regulator, receiver
GT370_RS19760	COG1573	uracil-dna glycosylase
GT370_RS19770	COG0583	DNA-binding transcription factor activity
GT370_RS19775	COG1028	Short-chain dehydrogenase reductase Sdr
GT370_RS19780	COG3959	Transketolase, thiamine diphosphate binding domain
GT370_RS19785	COG3959	Transketolase, thiamine diphosphate binding domain
GT370_RS19790	COG3958	Transketolase
GT370_RS19795	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GT370_RS19805	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GT370_RS19810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GT370_RS19835	COG3511	phospholipase C
GT370_RS19840	COG1858	cytochrome C peroxidase
GT370_RS19855	COG0318	PFAM AMP-dependent synthetase and ligase
GT370_RS19865	COG1414	Transcriptional regulator
GT370_RS19870	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GT370_RS19885	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GT370_RS19890	COG1028	Short-chain dehydrogenase reductase Sdr
GT370_RS19895	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GT370_RS19930	COG1501	Belongs to the glycosyl hydrolase 31 family
GT370_RS19965	COG1609	Transcriptional regulator
GT370_RS19975	COG0028	Belongs to the TPP enzyme family
GT370_RS19985	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GT370_RS20000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GT370_RS20005	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GT370_RS20015	COG0243	molybdopterin cofactor binding
GT370_RS20020	COG0243	molybdopterin cofactor binding
GT370_RS20085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GT370_RS20095	COG2271	Major facilitator Superfamily
GT370_RS20105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GT370_RS20120	COG2186	Transcriptional regulator
GT370_RS20135	COG3395	kinase activity
GT370_RS20140	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GT370_RS20145	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GT370_RS20160	COG1764	response to oxidative stress
GT370_RS20165	COG0678	peroxiredoxin activity
GT370_RS20235	COG1157	protein secretion by the type III secretion system
GT370_RS20250	COG1360	Flagellar Motor Protein
GT370_RS20255	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GT370_RS20260	COG1191	sigma factor activity
GT370_RS20295	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GT370_RS20315	COG1815	bacterial-type flagellum-dependent cell motility
GT370_RS20345	COG4786	Flagellar basal body rod
GT370_RS20350	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GT370_RS20355	COG1706	bacterial-type flagellum-dependent cell motility
GT370_RS20365	COG3951	Flagellar rod assembly protein muramidase FlgJ
GT370_RS20365	COG1705	Flagellar rod assembly protein muramidase FlgJ
GT370_RS20390	COG1987	bacterial-type flagellum assembly
GT370_RS20420	COG3387	PFAM Glycoside hydrolase 15-related
GT370_RS20440	COG3386	PFAM SMP-30 Gluconolaconase
GT370_RS20450	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GT370_RS20500	COG0356	it plays a direct role in the translocation of protons across the membrane
GT370_RS20505	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GT370_RS20510	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GT370_RS20530	COG2875	Belongs to the precorrin methyltransferase family
GT370_RS20545	COG2099	Precorrin-6x reductase
GT370_RS20590	COG1492	cobalamin metabolic process
GT370_RS20600	COG0778	Nitroreductase
GT370_RS20610	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GT370_RS20625	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GT370_RS20630	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate