locus-tag	class	description
ACEL_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACEL_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACEL_RS00010	COG0592	DNA-directed DNA polymerase activity
ACEL_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ACEL_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
ACEL_RS00025	COG0187	DNA topoisomerase II activity
ACEL_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ACEL_RS00090	COG3764	Sortase (surface protein transpeptidase)
ACEL_RS00105	COG2815	serine threonine protein kinase
ACEL_RS00105	COG0515	serine threonine protein kinase
ACEL_RS00110	COG0768	penicillin binding
ACEL_RS00125	COG1716	ATPase activity
ACEL_RS00130	COG1716	ATPase activity
ACEL_RS00160	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ACEL_RS00170	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACEL_RS00175	COG0022	dehydrogenase e1 component
ACEL_RS00190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACEL_RS00225	COG0038	chloride channel
ACEL_RS00245	COG2814	Major facilitator Superfamily
ACEL_RS00255	COG3001	Fructosamine kinase
ACEL_RS00260	COG4948	Mandelate Racemase Muconate Lactonizing
ACEL_RS00265	COG1017	nitric oxide dioxygenase activity
ACEL_RS00265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACEL_RS00280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ACEL_RS00285	COG0598	Magnesium transport protein CorA
ACEL_RS00300	COG0745	RESPONSE REGULATOR receiver
ACEL_RS00315	COG2897	thiosulfate sulfurtransferase activity
ACEL_RS00340	COG1490	D-aminoacyl-tRNA deacylase activity
ACEL_RS00370	COG0667	Aldo Keto reductase
ACEL_RS00390	COG0297	glycogen (starch) synthase activity
ACEL_RS00400	COG0588	phosphoglycerate mutase activity
ACEL_RS00420	COG4956	integral membrane protein (PIN domain superfamily)
ACEL_RS00425	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACEL_RS00430	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACEL_RS00435	COG0215	cysteine-tRNA ligase activity
ACEL_RS00445	COG3642	lipopolysaccharide core region biosynthetic process
ACEL_RS00470	COG0745	RESPONSE REGULATOR receiver
ACEL_RS00535	COG0459	protein refolding
ACEL_RS00545	COG3142	Participates in the control of copper homeostasis
ACEL_RS00550	COG1278	Cold shock
ACEL_RS00555	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACEL_RS00560	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ACEL_RS00565	COG2814	Major facilitator Superfamily
ACEL_RS00590	COG0667	Aldo Keto reductase
ACEL_RS00600	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ACEL_RS00610	COG0259	pyridoxamine-phosphate oxidase activity
ACEL_RS00620	COG1573	uracil-dna glycosylase
ACEL_RS00675	COG1472	Belongs to the glycosyl hydrolase 3 family
ACEL_RS00690	COG1175	transmembrane transport
ACEL_RS00695	COG0395	ABC-type sugar transport system, permease component
ACEL_RS00700	COG2723	6-phospho-beta-galactosidase activity
ACEL_RS00755	COG1609	Transcriptional regulator
ACEL_RS00770	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACEL_RS00775	COG0667	Aldo Keto reductase
ACEL_RS00800	COG1131	(ABC) transporter
ACEL_RS00825	COG1970	mechanosensitive ion channel activity
ACEL_RS00835	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ACEL_RS00840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACEL_RS00865	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ACEL_RS00875	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ACEL_RS00885	COG0315	cyclic pyranopterin monophosphate synthase activity
ACEL_RS00890	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACEL_RS00925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACEL_RS00930	COG0084	hydrolase, TatD family'
ACEL_RS00940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACEL_RS00950	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ACEL_RS00960	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACEL_RS01005	COG2837	iron assimilation
ACEL_RS01015	COG1131	(ABC) transporter
ACEL_RS01025	COG4585	Histidine kinase
ACEL_RS01030	COG2197	response regulator
ACEL_RS01040	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ACEL_RS01045	COG0791	NLP P60 protein
ACEL_RS01045	COG3883	PFAM NLP P60 protein
ACEL_RS01050	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ACEL_RS01065	COG0037	tRNA processing
ACEL_RS01070	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ACEL_RS01075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACEL_RS01080	COG0302	gtp cyclohydrolase
ACEL_RS01085	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ACEL_RS01085	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACEL_RS01095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ACEL_RS01095	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ACEL_RS01110	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ACEL_RS01115	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ACEL_RS01120	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ACEL_RS01130	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ACEL_RS01140	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ACEL_RS01160	COG2201	protein-glutamate methylesterase activity
ACEL_RS01200	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ACEL_RS01210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACEL_RS01230	COG0113	porphobilinogen synthase activity
ACEL_RS01235	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACEL_RS01235	COG1648	precorrin-2 dehydrogenase activity
ACEL_RS01240	COG0181	hydroxymethylbilane synthase activity
ACEL_RS01245	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ACEL_RS01250	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ACEL_RS01280	COG0123	including yeast histone deacetylase and acetoin utilization protein
ACEL_RS01290	COG0506	proline dehydrogenase activity
ACEL_RS01295	COG1082	Xylose isomerase domain protein TIM barrel
ACEL_RS01300	COG0406	alpha-ribazole phosphatase activity
ACEL_RS01305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACEL_RS01310	COG0785	Cytochrome C biogenesis protein
ACEL_RS01320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACEL_RS01325	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACEL_RS01330	COG0109	protoheme IX farnesyltransferase activity
ACEL_RS01335	COG0163	prenyltransferase activity
ACEL_RS01345	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACEL_RS01355	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACEL_RS01365	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACEL_RS01370	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACEL_RS01375	COG2226	methyltransferase
ACEL_RS01380	COG0644	oxidoreductase
ACEL_RS01390	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACEL_RS01395	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACEL_RS01400	COG0649	NAD binding
ACEL_RS01415	COG1034	ATP synthesis coupled electron transport
ACEL_RS01420	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACEL_RS01425	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACEL_RS01435	COG0713	ATP synthesis coupled electron transport
ACEL_RS01450	COG1007	ATP synthesis coupled electron transport
ACEL_RS01455	COG0142	geranyltranstransferase activity
ACEL_RS01465	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACEL_RS01470	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACEL_RS01470	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACEL_RS01480	COG1666	GTP binding
ACEL_RS01500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACEL_RS01505	COG2030	dehydratase
ACEL_RS01515	COG1309	transcriptional regulator
ACEL_RS01520	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ACEL_RS01525	COG0436	Aminotransferase
ACEL_RS01535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACEL_RS01545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACEL_RS01550	COG0081	regulation of translation
ACEL_RS01555	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACEL_RS01560	COG0222	ribosome binding
ACEL_RS01565	COG0085	RNA polymerase activity
ACEL_RS01570	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACEL_RS01575	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACEL_RS01580	COG0049	tRNA binding
ACEL_RS01585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACEL_RS01590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACEL_RS01595	COG0051	transcription antitermination factor activity, RNA binding
ACEL_RS01600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACEL_RS01605	COG0088	Forms part of the polypeptide exit tunnel
ACEL_RS01610	COG0089	rRNA binding
ACEL_RS01615	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACEL_RS01620	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACEL_RS01625	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACEL_RS01630	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACEL_RS01635	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACEL_RS01640	COG0255	Belongs to the universal ribosomal protein uL29 family
ACEL_RS01645	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACEL_RS01650	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACEL_RS01655	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ACEL_RS01660	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACEL_RS01665	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACEL_RS01670	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACEL_RS01675	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACEL_RS01680	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACEL_RS01685	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACEL_RS01690	COG1841	ribosomal large subunit assembly
ACEL_RS01695	COG0200	Binds to the 23S rRNA
ACEL_RS01705	COG0563	adenylate kinase activity
ACEL_RS01715	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACEL_RS01720	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACEL_RS01725	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ACEL_RS01730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACEL_RS01735	COG0202	RNA polymerase activity
ACEL_RS01745	COG0101	tRNA pseudouridine synthase activity
ACEL_RS01770	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACEL_RS01775	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACEL_RS01780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACEL_RS01785	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACEL_RS01800	COG2409	Drug exporters of the RND superfamily
ACEL_RS01815	COG1595	DNA-templated transcription, initiation
ACEL_RS01825	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACEL_RS01830	COG1129	ABC transporter
ACEL_RS01840	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACEL_RS01845	COG1573	uracil-dna glycosylase
ACEL_RS01850	COG0802	atpase or kinase
ACEL_RS01860	COG1247	-acetyltransferase
ACEL_RS01865	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACEL_RS01875	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ACEL_RS01880	COG0459	protein refolding
ACEL_RS01890	COG2201	protein-glutamate methylesterase activity
ACEL_RS01900	COG0516	GMP reductase activity
ACEL_RS01905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACEL_RS01915	COG1605	Chorismate mutase
ACEL_RS01920	COG0519	Catalyzes the synthesis of GMP from XMP
ACEL_RS01920	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACEL_RS01935	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACEL_RS01950	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACEL_RS01950	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACEL_RS01965	COG0045	succinate-CoA ligase (ADP-forming) activity
ACEL_RS01985	COG0138	bifunctional purine biosynthesis protein purh
ACEL_RS01990	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACEL_RS02010	COG1253	flavin adenine dinucleotide binding
ACEL_RS02015	COG0180	Tryptophanyl-tRNA synthetase
ACEL_RS02025	COG1278	Cold shock
ACEL_RS02030	COG1686	Belongs to the peptidase S11 family
ACEL_RS02040	COG2815	serine threonine protein kinase
ACEL_RS02040	COG0515	serine threonine protein kinase
ACEL_RS02050	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ACEL_RS02065	COG1024	Enoyl-CoA hydratase
ACEL_RS02070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACEL_RS02085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACEL_RS02095	COG1960	acyl-CoA dehydrogenase activity
ACEL_RS02105	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACEL_RS02110	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ACEL_RS02120	COG1607	acyl-coa hydrolase
ACEL_RS02125	COG1316	TRANSCRIPTIONal
ACEL_RS02130	COG1316	TRANSCRIPTIONal
ACEL_RS02170	COG0438	transferase activity, transferring glycosyl groups
ACEL_RS02215	COG0438	transferase activity, transferring glycosyl groups
ACEL_RS02220	COG2247	cell wall binding repeat
ACEL_RS02220	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACEL_RS02225	COG1063	alcohol dehydrogenase
ACEL_RS02230	COG1414	Transcriptional regulator
ACEL_RS02255	COG1175	transmembrane transport
ACEL_RS02260	COG0395	ABC-type sugar transport system, permease component
ACEL_RS02265	COG1012	belongs to the aldehyde dehydrogenase family
ACEL_RS02270	COG0463	Glycosyl transferase, family 2
ACEL_RS02330	COG0438	transferase activity, transferring glycosyl groups
ACEL_RS02335	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
ACEL_RS02340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACEL_RS02345	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACEL_RS02355	COG1834	amidinotransferase
ACEL_RS02360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACEL_RS02365	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ACEL_RS02410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACEL_RS02415	COG2835	tetraacyldisaccharide 4'-kinase activity
ACEL_RS02425	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ACEL_RS02430	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ACEL_RS02460	COG3480	Lon protease (S16) C-terminal proteolytic domain
ACEL_RS02470	COG0667	Aldo Keto reductase
ACEL_RS02475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACEL_RS02500	COG2814	Major facilitator Superfamily
ACEL_RS02510	COG0697	spore germination
ACEL_RS02515	COG1872	DUF167
ACEL_RS02530	COG0500	methyltransferase
ACEL_RS02535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACEL_RS02610	COG2271	Major facilitator Superfamily
ACEL_RS02620	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ACEL_RS02625	COG1140	nitrate reductase beta subunit
ACEL_RS02675	COG0589	response to stress
ACEL_RS02680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACEL_RS02680	COG0045	succinate-CoA ligase (ADP-forming) activity
ACEL_RS02680	COG1042	CoA-binding domain protein
ACEL_RS02685	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ACEL_RS02690	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACEL_RS02700	COG0425	Belongs to the sulfur carrier protein TusA family
ACEL_RS02730	COG2353	YceI-like domain
ACEL_RS02745	COG0483	inositol monophosphate 1-phosphatase activity
ACEL_RS02750	COG1162	GTPase activity
ACEL_RS02755	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACEL_RS02760	COG2135	peptidase activity
ACEL_RS02770	COG1595	DNA-templated transcription, initiation
ACEL_RS02790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACEL_RS02795	COG1937	Protein conserved in bacteria
ACEL_RS02820	COG0439	Biotin carboxylase
ACEL_RS02825	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ACEL_RS02835	COG2188	Transcriptional regulator
ACEL_RS02840	COG2182	Extracellular solute-binding protein
ACEL_RS02845	COG1175	transmembrane transport
ACEL_RS02850	COG0395	ABC-type sugar transport system, permease component
ACEL_RS02860	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACEL_RS02865	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ACEL_RS02870	COG3842	ATPase activity
ACEL_RS02890	COG4821	SIS domain
ACEL_RS02920	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ACEL_RS02935	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ACEL_RS02945	COG1846	Transcriptional regulator
ACEL_RS02945	COG1940	carbohydrate kinase activity
ACEL_RS02950	COG4821	SIS domain
ACEL_RS02955	COG1879	ABC-type sugar transport system periplasmic component
ACEL_RS02960	COG1129	ABC transporter
ACEL_RS02965	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACEL_RS02970	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACEL_RS02980	COG1082	Xylose isomerase domain protein TIM barrel
ACEL_RS02985	COG0673	inositol 2-dehydrogenase activity
ACEL_RS03000	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACEL_RS03000	COG0567	Dehydrogenase, E1 component
ACEL_RS03010	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACEL_RS03015	COG0022	dehydrogenase e1 component
ACEL_RS03020	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ACEL_RS03030	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ACEL_RS03035	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ACEL_RS03040	COG1984	allophanate hydrolase subunit 2
ACEL_RS03045	COG2239	Acts as a magnesium transporter
ACEL_RS03050	COG1914	H( )-stimulated, divalent metal cation uptake system
ACEL_RS03055	COG4988	ABC transporter
ACEL_RS03060	COG4988	ABC transporter
ACEL_RS03065	COG1294	oxidase, subunit
ACEL_RS03070	COG1271	oxidase subunit
ACEL_RS03075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACEL_RS03090	COG3386	PFAM SMP-30 Gluconolaconase
ACEL_RS03100	COG1846	Transcriptional regulator
ACEL_RS03105	COG2814	Major facilitator Superfamily
ACEL_RS03140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ACEL_RS03150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ACEL_RS03160	COG4733	cellulase activity
ACEL_RS03160	COG5297	Belongs to the glycosyl hydrolase family 6
ACEL_RS03180	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ACEL_RS03200	COG3189	MarR family transcriptional regulator
ACEL_RS03205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACEL_RS03225	COG0183	Belongs to the thiolase family
ACEL_RS03230	COG0745	RESPONSE REGULATOR receiver
ACEL_RS03235	COG0018	arginyl-trna synthetase
ACEL_RS03240	COG0019	diaminopimelate decarboxylase activity
ACEL_RS03245	COG0460	homoserine dehydrogenase
ACEL_RS03250	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACEL_RS03255	COG0083	homoserine kinase activity
ACEL_RS03265	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACEL_RS03270	COG1215	transferase activity, transferring glycosyl groups
ACEL_RS03280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACEL_RS03285	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ACEL_RS03290	COG1011	Hydrolase
ACEL_RS03295	COG0254	rRNA binding
ACEL_RS03300	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACEL_RS03305	COG2890	protein-(glutamine-N5) methyltransferase activity
ACEL_RS03330	COG0356	it plays a direct role in the translocation of protons across the membrane
ACEL_RS03335	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACEL_RS03340	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ACEL_RS03345	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACEL_RS03350	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACEL_RS03355	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACEL_RS03360	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ACEL_RS03365	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACEL_RS03390	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACEL_RS03395	COG0714	Associated with various cellular activities
ACEL_RS03420	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
ACEL_RS03435	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ACEL_RS03440	COG0006	proline dipeptidase activity
ACEL_RS03455	COG0183	Belongs to the thiolase family
ACEL_RS03465	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACEL_RS03465	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACEL_RS03475	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ACEL_RS03480	COG3281	Trehalose synthase
ACEL_RS03485	COG0366	Alpha amylase catalytic
ACEL_RS03490	COG0366	Alpha amylase catalytic
ACEL_RS03500	COG0058	SHG alpha-glucan phosphorylase activity
ACEL_RS03520	COG2086	electron transfer activity
ACEL_RS03525	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ACEL_RS03545	COG0482	sulfurtransferase activity
ACEL_RS03570	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACEL_RS03580	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACEL_RS03585	COG0154	amidase activity
ACEL_RS03590	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACEL_RS03600	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACEL_RS03605	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACEL_RS03610	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACEL_RS03625	COG0129	dihydroxy-acid dehydratase activity
ACEL_RS03630	COG0028	Belongs to the TPP enzyme family
ACEL_RS03635	COG0440	acetolactate synthase activity
ACEL_RS03640	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ACEL_RS03645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACEL_RS03650	COG0473	3-isopropylmalate dehydrogenase activity
ACEL_RS03655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACEL_RS03660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACEL_RS03665	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACEL_RS03670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACEL_RS03710	COG1349	DNA-binding transcription factor activity
ACEL_RS03715	COG1830	Aldolase
ACEL_RS03725	COG0277	FAD linked oxidase domain protein
ACEL_RS03735	COG1216	Glycosyl transferase, family 2
ACEL_RS03735	COG0438	transferase activity, transferring glycosyl groups
ACEL_RS03740	COG0651	ATP synthesis coupled electron transport
ACEL_RS03745	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACEL_RS03750	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACEL_RS03750	COG0649	NAD binding
ACEL_RS03750	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACEL_RS03755	COG0651	ATP synthesis coupled electron transport
ACEL_RS03775	COG0215	cysteine-tRNA ligase activity
ACEL_RS03780	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ACEL_RS03785	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ACEL_RS03790	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACEL_RS03795	COG0740	serine-type endopeptidase activity
ACEL_RS03800	COG0740	serine-type endopeptidase activity
ACEL_RS03805	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACEL_RS03815	COG0525	valine-tRNA ligase activity
ACEL_RS03820	COG0285	dihydrofolate synthase activity
ACEL_RS03830	COG1131	(ABC) transporter
ACEL_RS03835	COG0842	Transport permease protein
ACEL_RS03845	COG0105	UTP biosynthetic process
ACEL_RS03850	COG1077	Cell shape determining protein MreB Mrl
ACEL_RS03865	COG0768	penicillin binding
ACEL_RS03870	COG0772	Belongs to the SEDS family
ACEL_RS03885	COG1530	ribonuclease E activity
ACEL_RS03890	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ACEL_RS03895	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ACEL_RS03900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACEL_RS03905	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ACEL_RS03915	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ACEL_RS03920	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ACEL_RS03945	COG1968	undecaprenyl-diphosphatase activity
ACEL_RS03955	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ACEL_RS03960	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ACEL_RS03965	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACEL_RS03975	COG0495	leucyl-tRNA aminoacylation
ACEL_RS03980	COG1307	EDD domain protein, DegV family
ACEL_RS03985	COG1596	polysaccharide export
ACEL_RS03985	COG1555	photosystem II stabilization
ACEL_RS04000	COG0268	Binds directly to 16S ribosomal RNA
ACEL_RS04010	COG0481	GTPase activity
ACEL_RS04015	COG2258	MOSC domain
ACEL_RS04035	COG1420	regulation of RNA biosynthetic process
ACEL_RS04040	COG0484	heat shock protein binding
ACEL_RS04060	COG0537	adenosine 5'-monophosphoramidase activity
ACEL_RS04070	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACEL_RS04090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACEL_RS04095	COG1381	Involved in DNA repair and RecF pathway recombination
ACEL_RS04100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACEL_RS04110	COG0423	glycine-tRNA ligase activity
ACEL_RS04125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACEL_RS04125	COG0574	Belongs to the PEP-utilizing enzyme family
ACEL_RS04130	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ACEL_RS04145	COG0384	phenazine biosynthesis protein PhzF
ACEL_RS04215	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ACEL_RS04265	COG2323	membrane
ACEL_RS04285	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ACEL_RS04290	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ACEL_RS04295	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ACEL_RS04300	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ACEL_RS04305	COG1256	bacterial-type flagellum assembly
ACEL_RS04305	COG4786	Flagellar basal body rod
ACEL_RS04335	COG1815	bacterial-type flagellum-dependent cell motility
ACEL_RS04340	COG1558	bacterial-type flagellum-dependent cell motility
ACEL_RS04345	COG1677	Flagellar hook-basal body complex protein FliE
ACEL_RS04350	COG1766	The M ring may be actively involved in energy transduction
ACEL_RS04370	COG1157	protein secretion by the type III secretion system
ACEL_RS04380	COG0741	lytic transglycosylase activity
ACEL_RS04420	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACEL_RS04425	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACEL_RS04435	COG1338	Plays a role in the flagellum-specific transport system
ACEL_RS04445	COG1684	flagellar biosynthetic protein fliR
ACEL_RS04455	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACEL_RS04480	COG0492	ferredoxin-NADP+ reductase activity
ACEL_RS04500	COG1609	Transcriptional regulator
ACEL_RS04515	COG2160	L-arabinose isomerase activity
ACEL_RS04530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACEL_RS04535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACEL_RS04570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACEL_RS04580	COG0251	oxidation-reduction process
ACEL_RS04635	COG2080	2 iron, 2 sulfur cluster binding
ACEL_RS04640	COG2010	Cytochrome c
ACEL_RS04640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACEL_RS04645	COG2084	Dehydrogenase
ACEL_RS04680	COG0246	Mannitol dehydrogenase
ACEL_RS04715	COG1881	PFAM PEBP family protein
ACEL_RS04730	COG0586	Pfam SNARE associated Golgi protein
ACEL_RS04740	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACEL_RS04745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACEL_RS04745	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACEL_RS04750	COG0174	glutamine synthetase
ACEL_RS04755	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ACEL_RS04785	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACEL_RS04790	COG0321	lipoyl(octanoyl) transferase activity
ACEL_RS04835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACEL_RS04840	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACEL_RS04845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACEL_RS04870	COG3845	ABC transporter
ACEL_RS04875	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ACEL_RS04895	COG0667	Aldo Keto reductase
ACEL_RS04915	COG0501	Belongs to the peptidase M48B family
ACEL_RS04930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACEL_RS04935	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ACEL_RS04940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACEL_RS04960	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ACEL_RS04965	COG0723	plastoquinol--plastocyanin reductase activity
ACEL_RS04970	COG2010	Cytochrome c
ACEL_RS04975	COG1845	cytochrome c oxidase, subunit III
ACEL_RS04985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACEL_RS05015	COG0438	transferase activity, transferring glycosyl groups
ACEL_RS05025	COG3850	Histidine kinase
ACEL_RS05045	COG1940	carbohydrate kinase activity
ACEL_RS05060	COG0204	Acyl-transferase
ACEL_RS05065	COG0205	6-phosphofructokinase activity
ACEL_RS05070	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ACEL_RS05075	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ACEL_RS05080	COG0515	serine threonine protein kinase
ACEL_RS05080	COG2815	serine threonine protein kinase
ACEL_RS05085	COG2022	thiamine diphosphate biosynthetic process
ACEL_RS05095	COG2022	thiamine diphosphate biosynthetic process
ACEL_RS05095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACEL_RS05100	COG0352	thiamine-phosphate diphosphorylase activity
ACEL_RS05110	COG0442	prolyl-tRNA aminoacylation
ACEL_RS05150	COG0714	Associated with various cellular activities
ACEL_RS05155	COG2001	Belongs to the MraZ family
ACEL_RS05160	COG0275	rRNA processing
ACEL_RS05170	COG0768	penicillin binding
ACEL_RS05175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACEL_RS05185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACEL_RS05190	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACEL_RS05200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACEL_RS05205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACEL_RS05210	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACEL_RS05215	COG1496	oxidoreductase activity
ACEL_RS05220	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ACEL_RS05235	COG0543	2 iron, 2 sulfur cluster binding
ACEL_RS05255	COG0375	protein maturation
ACEL_RS05275	COG1799	cell septum assembly
ACEL_RS05305	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACEL_RS05315	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACEL_RS05330	COG0432	Pfam Uncharacterised protein family UPF0047
ACEL_RS05335	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACEL_RS05340	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACEL_RS05355	COG1028	Short-chain dehydrogenase reductase Sdr
ACEL_RS05365	COG0402	S-adenosylhomocysteine deaminase activity
ACEL_RS05370	COG0006	proline dipeptidase activity
ACEL_RS05380	COG2084	Dehydrogenase
ACEL_RS05385	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ACEL_RS05390	COG0022	dehydrogenase e1 component
ACEL_RS05395	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACEL_RS05405	COG1129	ABC transporter
ACEL_RS05415	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ACEL_RS05420	COG0156	8-amino-7-oxononanoate synthase activity
ACEL_RS05445	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACEL_RS05450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACEL_RS05455	COG0131	Imidazoleglycerol-phosphate dehydratase
ACEL_RS05460	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ACEL_RS05465	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACEL_RS05470	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACEL_RS05480	COG3279	Response regulator of the LytR AlgR family
ACEL_RS05490	COG1584	GPR1 FUN34 yaaH family protein
ACEL_RS05495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACEL_RS05500	COG0107	imidazoleglycerol-phosphate synthase activity
ACEL_RS05505	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACEL_RS05510	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACEL_RS05520	COG0134	indole-3-glycerol-phosphate synthase activity
ACEL_RS05525	COG0133	tryptophan synthase activity
ACEL_RS05530	COG0159	tryptophan synthase activity
ACEL_RS05535	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ACEL_RS05545	COG0069	glutamate synthase activity
ACEL_RS05545	COG0067	glutamate synthase
ACEL_RS05545	COG0070	glutamate synthase
ACEL_RS05615	COG0237	dephospho-CoA kinase activity
ACEL_RS05630	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACEL_RS05630	COG0519	Catalyzes the synthesis of GMP from XMP
ACEL_RS05640	COG0174	glutamine synthetase
ACEL_RS05655	COG0519	Catalyzes the synthesis of GMP from XMP
ACEL_RS05655	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACEL_RS05665	COG3885	ferrous iron binding
ACEL_RS05665	COG2078	PFAM AMMECR1 domain protein
ACEL_RS05670	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACEL_RS05690	COG0556	nucleotide-excision repair
ACEL_RS05695	COG4552	Acetyltransferase involved in intracellular survival and related
ACEL_RS05705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACEL_RS05710	COG0322	excinuclease ABC activity
ACEL_RS05715	COG1660	Displays ATPase and GTPase activities
ACEL_RS05720	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ACEL_RS05725	COG1481	regulation of sporulation
ACEL_RS05730	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACEL_RS05760	COG4608	Belongs to the ABC transporter superfamily
ACEL_RS05765	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACEL_RS05770	COG0363	glucosamine-6-phosphate deaminase activity
ACEL_RS05785	COG0166	Belongs to the GPI family
ACEL_RS05790	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACEL_RS05795	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ACEL_RS05800	COG0109	protoheme IX farnesyltransferase activity
ACEL_RS05805	COG1940	carbohydrate kinase activity
ACEL_RS05810	COG4214	carbohydrate transport
ACEL_RS05845	COG0396	ATPase activity
ACEL_RS05850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACEL_RS05855	COG0822	iron-sulfur transferase activity
ACEL_RS05860	COG2151	metal-sulfur cluster biosynthetic enzyme
ACEL_RS05870	COG1132	(ABC) transporter
ACEL_RS05875	COG3387	PFAM Glycoside hydrolase 15-related
ACEL_RS05895	COG3360	Dodecin
ACEL_RS05920	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ACEL_RS05925	COG1388	LysM domain
ACEL_RS05930	COG1119	ATPase activity
ACEL_RS05960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACEL_RS05970	COG2223	nitrite transmembrane transporter activity
ACEL_RS05980	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ACEL_RS05990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACEL_RS06005	COG0667	Aldo Keto reductase
ACEL_RS06030	COG0215	cysteine-tRNA ligase activity
ACEL_RS06040	COG1410	methionine synthase
ACEL_RS06040	COG0646	methionine synthase
ACEL_RS06045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACEL_RS06060	COG0577	efflux transmembrane transporter activity
ACEL_RS06065	COG1136	(ABC) transporter
ACEL_RS06075	COG1994	Peptidase M50
ACEL_RS06075	COG0517	IMP dehydrogenase activity
ACEL_RS06090	COG1222	aaa ATPase
ACEL_RS06100	COG4122	O-methyltransferase activity
ACEL_RS06110	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ACEL_RS06115	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ACEL_RS06125	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ACEL_RS06130	COG0318	PFAM AMP-dependent synthetase and ligase
ACEL_RS06135	COG1960	acyl-CoA dehydrogenase activity
ACEL_RS06160	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACEL_RS06160	COG1902	pentaerythritol trinitrate reductase activity
ACEL_RS06165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACEL_RS06185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACEL_RS06190	COG0805	protein transport
ACEL_RS06200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACEL_RS06205	COG1960	acyl-CoA dehydrogenase activity
ACEL_RS06215	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ACEL_RS06220	COG0463	Glycosyl transferase, family 2
ACEL_RS06230	COG0800	Aldolase
ACEL_RS06255	COG2807	transmembrane transport
ACEL_RS06280	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACEL_RS06280	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACEL_RS06325	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACEL_RS06340	COG1160	GTP binding
ACEL_RS06345	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ACEL_RS06350	COG0287	Prephenate dehydrogenase
ACEL_RS06360	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ACEL_RS06365	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ACEL_RS06370	COG1994	Peptidase M50
ACEL_RS06385	COG0494	nUDIX hydrolase
ACEL_RS06390	COG0504	CTP synthase activity
ACEL_RS06400	COG0497	DNA recombination
ACEL_RS06405	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACEL_RS06425	COG0647	UMP catabolic process
ACEL_RS06460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACEL_RS06465	COG2094	Belongs to the DNA glycosylase MPG family
ACEL_RS06470	COG0165	Argininosuccinate lyase
ACEL_RS06475	COG0137	argininosuccinate synthase activity
ACEL_RS06485	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACEL_RS06495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACEL_RS06500	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ACEL_RS06505	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACEL_RS06510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACEL_RS06510	COG0072	phenylalanine-tRNA ligase activity
ACEL_RS06515	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACEL_RS06525	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACEL_RS06530	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ACEL_RS06535	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ACEL_RS06540	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ACEL_RS06545	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACEL_RS06550	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACEL_RS06550	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACEL_RS06570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ACEL_RS06580	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACEL_RS06585	COG0242	peptide deformylase activity
ACEL_RS06590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACEL_RS06595	COG1177	transmembrane transport
ACEL_RS06600	COG1176	ABC-type spermidine putrescine transport system, permease component I
ACEL_RS06610	COG3842	ATPase activity
ACEL_RS06615	COG1012	belongs to the aldehyde dehydrogenase family
ACEL_RS06625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACEL_RS06640	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ACEL_RS06650	COG1758	RNA polymerase activity
ACEL_RS06655	COG0194	GDP metabolic process
ACEL_RS06665	COG0284	orotidine-5'-phosphate decarboxylase activity
ACEL_RS06670	COG0167	dihydroorotate dehydrogenase activity
ACEL_RS06675	COG0543	2 iron, 2 sulfur cluster binding
ACEL_RS06680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ACEL_RS06685	COG0505	Belongs to the CarA family
ACEL_RS06690	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACEL_RS06695	COG0540	Belongs to the ATCase OTCase family
ACEL_RS06700	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ACEL_RS06710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACEL_RS06715	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACEL_RS06720	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ACEL_RS06725	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACEL_RS06730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACEL_RS06735	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACEL_RS06760	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ACEL_RS06785	COG4968	Prepilin-type N-terminal cleavage methylation domain
ACEL_RS06790	COG1459	type II secretion system
ACEL_RS06800	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACEL_RS06825	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACEL_RS06830	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ACEL_RS06840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACEL_RS06860	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACEL_RS06865	COG0124	histidyl-tRNA synthetase
ACEL_RS06880	COG0545	Peptidyl-prolyl cis-trans isomerase
ACEL_RS06885	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACEL_RS06890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACEL_RS06895	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACEL_RS06910	COG2255	four-way junction helicase activity
ACEL_RS06915	COG0632	four-way junction helicase activity
ACEL_RS06920	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ACEL_RS06925	COG0217	transcriptional regulatory protein
ACEL_RS06930	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ACEL_RS06935	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ACEL_RS06955	COG0438	transferase activity, transferring glycosyl groups
ACEL_RS06960	COG1560	Kdo2-lipid A biosynthetic process
ACEL_RS06965	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACEL_RS06980	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACEL_RS06985	COG1609	Transcriptional regulator
ACEL_RS07000	COG1175	transmembrane transport
ACEL_RS07005	COG0395	ABC-type sugar transport system, permease component
ACEL_RS07030	COG1129	ABC transporter
ACEL_RS07030	COG0842	Transport permease protein
ACEL_RS07070	COG1376	ErfK ybiS ycfS ynhG family protein
ACEL_RS07095	COG1793	dna ligase
ACEL_RS07110	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACEL_RS07115	COG3253	May function as heme-dependent peroxidase
ACEL_RS07125	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACEL_RS07140	COG4152	abc transporter atp-binding protein
ACEL_RS07150	COG3851	Histidine kinase
ACEL_RS07160	COG1404	Belongs to the peptidase S8 family
ACEL_RS07165	COG2197	response regulator
ACEL_RS07170	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ACEL_RS07180	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACEL_RS07185	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACEL_RS07195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACEL_RS07200	COG0531	amino acid
ACEL_RS07205	COG0569	domain protein
ACEL_RS07225	COG0756	dUTP diphosphatase activity
ACEL_RS07245	COG0823	Involved in the tonB-independent uptake of proteins
ACEL_RS07245	COG1506	peptidase
ACEL_RS07250	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACEL_RS07320	COG0501	Belongs to the peptidase M48B family
ACEL_RS07325	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ACEL_RS07330	COG0412	Dienelactone hydrolase
ACEL_RS07340	COG0626	cystathionine gamma-synthase activity
ACEL_RS07350	COG0187	DNA topoisomerase II activity
ACEL_RS07370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACEL_RS07415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACEL_RS07420	COG2151	metal-sulfur cluster biosynthetic enzyme
ACEL_RS07425	COG3396	Phenylacetate-CoA oxygenase
ACEL_RS07430	COG3460	Phenylacetate-CoA oxygenase
ACEL_RS07435	COG3396	Phenylacetate-CoA oxygenase
ACEL_RS07440	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACEL_RS07450	COG0215	cysteine-tRNA ligase activity
ACEL_RS07460	COG2205	protein histidine kinase activity
ACEL_RS07465	COG0745	RESPONSE REGULATOR receiver
ACEL_RS07480	COG1136	(ABC) transporter
ACEL_RS07485	COG1136	(ABC) transporter
ACEL_RS07485	COG0577	efflux transmembrane transporter activity
ACEL_RS07495	COG0673	inositol 2-dehydrogenase activity
ACEL_RS07510	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACEL_RS07510	COG2755	lipolytic protein G-D-S-L family
ACEL_RS07530	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
ACEL_RS07545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACEL_RS07570	COG0277	FAD linked oxidase domain protein
ACEL_RS07590	COG0071	Belongs to the small heat shock protein (HSP20) family
ACEL_RS07600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACEL_RS07605	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACEL_RS07615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACEL_RS07630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ACEL_RS07635	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ACEL_RS07640	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ACEL_RS07650	COG1196	nuclear chromosome segregation
ACEL_RS07655	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACEL_RS07655	COG2247	cell wall binding repeat
ACEL_RS07660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACEL_RS07670	COG1418	mRNA catabolic process
ACEL_RS07675	COG2137	regulation of response to DNA damage stimulus
ACEL_RS07680	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACEL_RS07700	COG1595	DNA-templated transcription, initiation
ACEL_RS07710	COG1201	RNA secondary structure unwinding
ACEL_RS07720	COG1546	Belongs to the CinA family
ACEL_RS07720	COG1058	Belongs to the CinA family
ACEL_RS07730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACEL_RS07740	COG1674	ftsk spoiiie
ACEL_RS07745	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ACEL_RS07750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACEL_RS07755	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ACEL_RS07765	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ACEL_RS07770	COG0612	Peptidase, M16
ACEL_RS07775	COG1185	polyribonucleotide nucleotidyltransferase activity
ACEL_RS07780	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACEL_RS07795	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACEL_RS07800	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACEL_RS07810	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACEL_RS07825	COG0779	Required for maturation of 30S ribosomal subunits
ACEL_RS07830	COG0442	prolyl-tRNA aminoacylation
ACEL_RS07845	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ACEL_RS07850	COG0750	zinc metalloprotease
ACEL_RS07895	COG0673	inositol 2-dehydrogenase activity
ACEL_RS07900	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACEL_RS07915	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACEL_RS07920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACEL_RS07925	COG0575	Belongs to the CDS family
ACEL_RS07930	COG0233	cytoplasmic translational termination
ACEL_RS07935	COG0528	UMP kinase activity
ACEL_RS07940	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACEL_RS07945	COG0052	Belongs to the universal ribosomal protein uS2 family
ACEL_RS07965	COG1191	sigma factor activity
ACEL_RS07985	COG0792	nuclease activity
ACEL_RS07990	COG4106	trans-aconitate 2-methyltransferase activity
ACEL_RS08005	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACEL_RS08020	COG0335	large ribosomal subunit rRNA binding
ACEL_RS08025	COG0336	Belongs to the RNA methyltransferase TrmD family
ACEL_RS08030	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ACEL_RS08035	COG1837	Belongs to the UPF0109 family
ACEL_RS08040	COG0228	four-way junction DNA binding
ACEL_RS08055	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ACEL_RS08095	COG1254	Belongs to the acylphosphatase family
ACEL_RS08100	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACEL_RS08105	COG0571	ribonuclease III activity
ACEL_RS08120	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACEL_RS08125	COG0742	ribosomal rna small subunit methyltransferase
ACEL_RS08135	COG1461	Dihydroxyacetone kinase
ACEL_RS08140	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ACEL_RS08145	COG0351	phosphomethylpyrimidine kinase
ACEL_RS08160	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACEL_RS08165	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACEL_RS08175	COG0776	regulation of translation
ACEL_RS08180	COG0066	3-isopropylmalate dehydratase activity
ACEL_RS08185	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ACEL_RS08190	COG1414	Transcriptional regulator
ACEL_RS08195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACEL_RS08200	COG2205	protein histidine kinase activity
ACEL_RS08205	COG0745	RESPONSE REGULATOR receiver
ACEL_RS08230	COG0698	ribose 5-phosphate isomerase
ACEL_RS08260	COG1505	serine-type exopeptidase activity
ACEL_RS08265	COG2205	protein histidine kinase activity
ACEL_RS08270	COG0745	RESPONSE REGULATOR receiver
ACEL_RS08285	COG1764	response to oxidative stress
ACEL_RS08330	COG1648	precorrin-2 dehydrogenase activity
ACEL_RS08330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACEL_RS08345	COG0529	Catalyzes the synthesis of activated sulfate
ACEL_RS08350	COG0629	single-stranded DNA binding
ACEL_RS08380	COG0577	efflux transmembrane transporter activity
ACEL_RS08380	COG1136	(ABC) transporter
ACEL_RS08385	COG0577	efflux transmembrane transporter activity
ACEL_RS08385	COG1136	(ABC) transporter
ACEL_RS08390	COG1803	Methylglyoxal synthase
ACEL_RS08405	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ACEL_RS08405	COG3608	succinylglutamate desuccinylase aspartoacylase
ACEL_RS08425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACEL_RS08450	COG1126	abc transporter atp-binding protein
ACEL_RS08455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACEL_RS08465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACEL_RS08470	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ACEL_RS08475	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ACEL_RS08480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACEL_RS08495	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACEL_RS08500	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ACEL_RS08510	COG1937	Protein conserved in bacteria
ACEL_RS08550	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ACEL_RS08565	COG2050	protein possibly involved in aromatic compounds catabolism
ACEL_RS08575	COG5001	Diguanylate cyclase
ACEL_RS08575	COG3300	MHYT domain
ACEL_RS08590	COG0302	gtp cyclohydrolase
ACEL_RS08630	COG2017	converts alpha-aldose to the beta-anomer
ACEL_RS08645	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ACEL_RS08665	COG1063	alcohol dehydrogenase
ACEL_RS08680	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACEL_RS08685	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ACEL_RS08690	COG1234	tRNA 3'-trailer cleavage
ACEL_RS08695	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ACEL_RS08730	COG1562	ergosterol biosynthetic process
ACEL_RS08740	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ACEL_RS08750	COG1657	PFAM Prenyltransferase squalene oxidase
ACEL_RS08760	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACEL_RS08780	COG1470	cell adhesion involved in biofilm formation
ACEL_RS08790	COG1678	Uncharacterized ACR, COG1678
ACEL_RS08795	COG1492	cobalamin metabolic process
ACEL_RS08825	COG1028	Short-chain dehydrogenase reductase Sdr
ACEL_RS08835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACEL_RS08840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACEL_RS08845	COG0667	Aldo Keto reductase
ACEL_RS08855	COG1335	isochorismatase
ACEL_RS08865	COG2814	Major facilitator Superfamily
ACEL_RS08875	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ACEL_RS08880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACEL_RS08880	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACEL_RS08885	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACEL_RS08900	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACEL_RS08905	COG0793	Belongs to the peptidase S41A family
ACEL_RS08910	COG2177	Part of the ABC transporter FtsEX involved in
ACEL_RS08915	COG2884	Cell division ATP-binding protein ftsE
ACEL_RS08925	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACEL_RS08995	COG2146	nitrite reductase [NAD(P)H] activity
ACEL_RS09000	COG2146	nitrite reductase [NAD(P)H] activity
ACEL_RS09000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACEL_RS09010	COG0243	molybdopterin cofactor binding
ACEL_RS09020	COG2223	nitrite transmembrane transporter activity
ACEL_RS09035	COG2902	Dehydrogenase
ACEL_RS09040	COG1012	belongs to the aldehyde dehydrogenase family
ACEL_RS09090	COG0653	protein targeting
ACEL_RS09095	COG2197	response regulator
ACEL_RS09100	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ACEL_RS09115	COG5401	PFAM Sporulation and spore germination
ACEL_RS09120	COG5002	protein histidine kinase activity
ACEL_RS09120	COG5000	phosphorelay sensor kinase activity
ACEL_RS09125	COG0745	RESPONSE REGULATOR receiver
ACEL_RS09145	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACEL_RS09155	COG0210	DNA helicase
ACEL_RS09165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACEL_RS09180	COG0210	DNA helicase
ACEL_RS09230	COG0745	RESPONSE REGULATOR receiver
ACEL_RS09240	COG0745	RESPONSE REGULATOR receiver
ACEL_RS09245	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACEL_RS09250	COG2201	protein-glutamate methylesterase activity
ACEL_RS09260	COG0835	chemotaxis
ACEL_RS09265	COG0643	Histidine kinase
ACEL_RS09265	COG0784	Response regulator, receiver
ACEL_RS09265	COG2198	Histidine kinase
ACEL_RS09270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACEL_RS09275	COG2095	MarC family integral membrane protein
ACEL_RS09305	COG3962	Belongs to the TPP enzyme family
ACEL_RS09310	COG3718	enzyme involved in inositol metabolism
ACEL_RS09320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACEL_RS09325	COG2188	Transcriptional regulator
ACEL_RS09330	COG0673	inositol 2-dehydrogenase activity
ACEL_RS09340	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACEL_RS09350	COG0673	inositol 2-dehydrogenase activity
ACEL_RS09355	COG1082	Xylose isomerase domain protein TIM barrel
ACEL_RS09365	COG1082	Xylose isomerase domain protein TIM barrel
ACEL_RS09375	COG0673	inositol 2-dehydrogenase activity
ACEL_RS09395	COG2239	Acts as a magnesium transporter
ACEL_RS09405	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ACEL_RS09410	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ACEL_RS09415	COG0297	glycogen (starch) synthase activity
ACEL_RS09425	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACEL_RS09440	COG1595	DNA-templated transcription, initiation
ACEL_RS09450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACEL_RS09450	COG0512	Glutamine amidotransferase of anthranilate synthase
ACEL_RS09455	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ACEL_RS09465	COG5002	protein histidine kinase activity
ACEL_RS09470	COG0745	RESPONSE REGULATOR receiver
ACEL_RS09480	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACEL_RS09485	COG1024	Enoyl-CoA hydratase
ACEL_RS09490	COG0519	Catalyzes the synthesis of GMP from XMP
ACEL_RS09500	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACEL_RS09510	COG1611	Belongs to the LOG family
ACEL_RS09520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACEL_RS09525	COG2171	N-acyltransferase activity
ACEL_RS09535	COG1760	l-serine dehydratase
ACEL_RS09540	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACEL_RS09545	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ACEL_RS09550	COG1028	Short-chain dehydrogenase reductase Sdr
ACEL_RS09555	COG1012	belongs to the aldehyde dehydrogenase family
ACEL_RS09560	COG0174	glutamine synthetase
ACEL_RS09565	COG2186	Transcriptional regulator
ACEL_RS09595	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACEL_RS09605	COG1322	Protein conserved in bacteria
ACEL_RS09610	COG0012	GTP binding
ACEL_RS09615	COG2154	pterin-4-alpha-carbinolamine dehydratase
ACEL_RS09645	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACEL_RS09650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACEL_RS09680	COG1570	exodeoxyribonuclease VII activity
ACEL_RS09685	COG1722	exodeoxyribonuclease VII activity
ACEL_RS09700	COG0114	fumarate hydratase activity
ACEL_RS09710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACEL_RS09720	COG1331	Highly conserved protein containing a thioredoxin domain
ACEL_RS09725	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACEL_RS09735	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACEL_RS09740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACEL_RS09745	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACEL_RS09795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACEL_RS09855	COG0148	phosphopyruvate hydratase activity
ACEL_RS09910	COG0438	transferase activity, transferring glycosyl groups
ACEL_RS09960	COG0438	transferase activity, transferring glycosyl groups
ACEL_RS09970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACEL_RS09990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACEL_RS10010	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACEL_RS10025	COG0579	oxidoreductase
ACEL_RS10040	COG0193	aminoacyl-tRNA hydrolase activity
ACEL_RS10045	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ACEL_RS10050	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACEL_RS10055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACEL_RS10065	COG1741	Belongs to the pirin family
ACEL_RS10070	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ACEL_RS10075	COG1518	maintenance of DNA repeat elements
ACEL_RS10110	COG0730	response to heat
ACEL_RS10130	COG1920	GTP binding
ACEL_RS10135	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
ACEL_RS10135	COG0778	Nitroreductase
ACEL_RS10150	COG1774	PSP1 C-terminal conserved region
ACEL_RS10170	COG0470	DNA polymerase III
ACEL_RS10175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACEL_RS10180	COG1754	DNA topoisomerase type I activity
ACEL_RS10180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ACEL_RS10185	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ACEL_RS10195	COG1366	Belongs to the anti-sigma-factor antagonist family
ACEL_RS10200	COG1111	helicase
ACEL_RS10200	COG1205	dead DEAH box helicase
ACEL_RS10245	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACEL_RS10250	COG3263	regulation of cellular component size
ACEL_RS10275	COG0596	Alpha beta hydrolase
ACEL_RS10310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACEL_RS10335	COG0003	Pfam Anion-transporting ATPase
ACEL_RS10345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACEL_RS10350	COG1610	YqeY-like protein
ACEL_RS10355	COG1408	metallophosphoesterase
ACEL_RS10365	COG0783	Belongs to the Dps family
ACEL_RS10415	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ACEL_RS10455	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ACEL_RS10475	COG0745	RESPONSE REGULATOR receiver
ACEL_RS10480	COG0456	acetyltransferase
ACEL_RS10480	COG0454	-acetyltransferase
ACEL_RS10510	COG1191	sigma factor activity
ACEL_RS10515	COG3469	chitinase activity
ACEL_RS10575	COG3458	cephalosporin-C deacetylase activity
ACEL_RS10580	COG1609	Transcriptional regulator
ACEL_RS10590	COG1175	transmembrane transport
ACEL_RS10595	COG1653	transport
ACEL_RS10600	COG1472	Belongs to the glycosyl hydrolase 3 family
ACEL_RS10620	COG0175	sulfate reduction
ACEL_RS10625	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACEL_RS10660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACEL_RS10700	COG2115	Belongs to the xylose isomerase family
ACEL_RS10705	COG1070	Carbohydrate kinase
ACEL_RS10735	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACEL_RS10750	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACEL_RS10755	COG0047	phosphoribosylformylglycinamidine synthase activity
ACEL_RS10760	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACEL_RS10790	COG0305	Participates in initiation and elongation during chromosome replication
ACEL_RS10815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACEL_RS10825	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACEL_RS10875	COG2200	EAL domain
ACEL_RS10875	COG2199	diguanylate cyclase activity
ACEL_RS10875	COG3287	FIST C domain
ACEL_RS10895	COG0561	phosphatase activity
ACEL_RS10900	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACEL_RS10905	COG0077	Prephenate dehydratase
ACEL_RS10930	COG0393	Putative heavy-metal-binding
ACEL_RS10960	COG0717	Belongs to the dCTP deaminase family
ACEL_RS10965	COG2181	nitrate reductase activity
ACEL_RS10965	COG0247	lactate metabolic process
ACEL_RS10975	COG0443	Heat shock 70 kDa protein
ACEL_RS10980	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACEL_RS10990	COG0484	heat shock protein binding
ACEL_RS10995	COG0789	Transcriptional regulator
ACEL_RS11000	COG0542	response to heat
ACEL_RS11005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACEL_RS11020	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACEL_RS11025	COG0586	Pfam SNARE associated Golgi protein
ACEL_RS11035	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACEL_RS11040	COG0151	Belongs to the GarS family
ACEL_RS11045	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACEL_RS11050	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ACEL_RS11055	COG0359	binds to the 23S rRNA
ACEL_RS11060	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACEL_RS11070	COG0360	Binds together with S18 to 16S ribosomal RNA
ACEL_RS11080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACEL_RS11100	COG0617	tRNA 3'-terminal CCA addition
ACEL_RS11135	COG1595	DNA-templated transcription, initiation
ACEL_RS11145	COG0492	ferredoxin-NADP+ reductase activity
ACEL_RS11150	COG3118	belongs to the thioredoxin family
ACEL_RS11165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACEL_RS11170	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACEL_RS11180	COG1192	Involved in chromosome partitioning
ACEL_RS11185	COG0357	Ribosomal RNA small subunit methyltransferase G
ACEL_RS11195	COG0706	membrane insertase activity
ACEL_RS11205	COG0594	ribonuclease P activity
ACEL_RS11300	COG0203	ribosomal protein L17
ACEL_RS11305	COG1846	Transcriptional regulator
ACEL_RS11330	COG3858	chitin binding
ACEL_RS11345	COG0438	transferase activity, transferring glycosyl groups
ACEL_RS11350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACEL_RS11365	COG2971	BadF BadG BcrA BcrD
ACEL_RS11375	COG1876	peptidase activity
ACEL_RS11405	COG0746	molybdenum cofactor guanylyltransferase activity
ACEL_RS11420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACEL_RS11435	COG5001	Diguanylate cyclase
ACEL_RS11450	COG1388	LysM domain
ACEL_RS11450	COG0791	NLP P60 protein
ACEL_RS11450	COG3103	Sh3 type 3 domain protein
ACEL_RS11460	COG3599	regulation of cell shape
ACEL_RS11485	COG0126	phosphoglycerate kinase activity
ACEL_RS11495	COG0739	heme binding
ACEL_RS11505	COG4968	Prepilin-type N-terminal cleavage methylation domain
ACEL_RS11510	COG1862	Preprotein translocase
ACEL_RS11585	COG1674	ftsk spoiiie
ACEL_RS11615	COG2971	BadF BadG BcrA BcrD
ACEL_RS11630	COG0840	transmembrane signaling receptor activity
ACEL_RS11635	COG0643	Histidine kinase
ACEL_RS11635	COG2198	Histidine kinase
ACEL_RS11640	COG0745	RESPONSE REGULATOR receiver
ACEL_RS11670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACEL_RS11690	COG1216	Glycosyl transferase, family 2
ACEL_RS11695	COG0736	holo-[acyl-carrier-protein] synthase activity
ACEL_RS11745	COG0215	cysteine-tRNA ligase activity
ACEL_RS11765	COG2205	protein histidine kinase activity