locus-tag	class	description
ACAV_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACAV_RS00060	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ACAV_RS00075	COG4650	regulator
ACAV_RS00085	COG1690	Belongs to the RtcB family
ACAV_RS00090	COG3541	Predicted nucleotidyltransferase
ACAV_RS00095	COG0430	RNA-3'-phosphate cyclase activity
ACAV_RS00105	COG1764	response to oxidative stress
ACAV_RS00125	COG1199	ATP-dependent helicase activity
ACAV_RS00140	COG2176	DNA-directed DNA polymerase activity
ACAV_RS00155	COG0583	DNA-binding transcription factor activity
ACAV_RS00160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACAV_RS00165	COG0791	NLP P60 protein
ACAV_RS00170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ACAV_RS00190	COG2974	May be involved in recombination
ACAV_RS00195	COG0700	Nucleoside recognition
ACAV_RS00215	COG0183	Belongs to the thiolase family
ACAV_RS00220	COG0789	Transcriptional regulator
ACAV_RS00235	COG0840	transmembrane signaling receptor activity
ACAV_RS00260	COG0642	Histidine kinase
ACAV_RS00270	COG1902	pentaerythritol trinitrate reductase activity
ACAV_RS00275	COG4521	taurine ABC transporter
ACAV_RS00280	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ACAV_RS00285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACAV_RS00305	COG0445	tRNA wobble uridine modification
ACAV_RS00310	COG0357	Ribosomal RNA small subunit methyltransferase G
ACAV_RS00315	COG1280	lysine exporter protein (LysE YggA)
ACAV_RS00320	COG1192	Involved in chromosome partitioning
ACAV_RS00350	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS00355	COG1024	Enoyl-CoA hydratase
ACAV_RS00365	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACAV_RS00380	COG4977	sequence-specific DNA binding
ACAV_RS00395	COG0493	'glutamate synthase
ACAV_RS00420	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ACAV_RS00420	COG0546	phosphoglycolate phosphatase activity
ACAV_RS00435	COG2272	Belongs to the type-B carboxylesterase lipase family
ACAV_RS00455	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
ACAV_RS00490	COG3411	Ferredoxin
ACAV_RS00510	COG2329	Antibiotic biosynthesis monooxygenase
ACAV_RS00585	COG0277	FAD linked oxidase domain protein
ACAV_RS00600	COG2096	Adenosyltransferase
ACAV_RS00625	COG2050	protein possibly involved in aromatic compounds catabolism
ACAV_RS00640	COG2233	PERMEase
ACAV_RS00650	COG0840	transmembrane signaling receptor activity
ACAV_RS00660	COG2203	Gaf domain
ACAV_RS00660	COG2199	diguanylate cyclase activity
ACAV_RS00665	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ACAV_RS00695	COG1116	anion transmembrane transporter activity
ACAV_RS00700	COG0395	ABC-type sugar transport system, permease component
ACAV_RS00710	COG0583	DNA-binding transcription factor activity
ACAV_RS00725	COG1414	Transcriptional regulator
ACAV_RS00730	COG0501	Belongs to the peptidase M48B family
ACAV_RS00740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACAV_RS00750	COG2423	ornithine cyclodeaminase activity
ACAV_RS00760	COG1183	phosphatidylcholine synthase activity
ACAV_RS00765	COG0850	regulation of cytokinetic process
ACAV_RS00775	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ACAV_RS00780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACAV_RS00795	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ACAV_RS00800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACAV_RS00840	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ACAV_RS00845	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS00850	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ACAV_RS00855	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ACAV_RS00860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACAV_RS00875	COG1960	acyl-CoA dehydrogenase activity
ACAV_RS00900	COG2271	Major facilitator Superfamily
ACAV_RS00910	COG2423	ornithine cyclodeaminase activity
ACAV_RS00970	COG0840	transmembrane signaling receptor activity
ACAV_RS00995	COG2204	response regulator
ACAV_RS01015	COG0583	DNA-binding transcription factor activity
ACAV_RS01030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACAV_RS01075	COG1309	transcriptional regulator
ACAV_RS01095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ACAV_RS01105	COG2326	polyphosphate kinase activity
ACAV_RS01185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACAV_RS01195	COG0583	DNA-binding transcription factor activity
ACAV_RS01220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACAV_RS01225	COG0583	DNA-binding transcription factor activity
ACAV_RS01240	COG0583	DNA-binding transcription factor activity
ACAV_RS01260	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
ACAV_RS01270	COG0765	amino acid transport
ACAV_RS01275	COG0765	amino acid transport
ACAV_RS01295	COG1410	methionine synthase
ACAV_RS01295	COG0646	methionine synthase
ACAV_RS01360	COG0583	DNA-binding transcription factor activity
ACAV_RS01375	COG0840	transmembrane signaling receptor activity
ACAV_RS01385	COG4191	Histidine kinase
ACAV_RS01395	COG0606	chelatase, subunit chli
ACAV_RS01405	COG0347	Belongs to the P(II) protein family
ACAV_RS01410	COG0004	ammonium transporteR
ACAV_RS01445	COG0277	FAD linked oxidase domain protein
ACAV_RS01455	COG0247	lactate metabolic process
ACAV_RS01485	COG0386	Belongs to the glutathione peroxidase family
ACAV_RS01495	COG0477	Major facilitator Superfamily
ACAV_RS01500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACAV_RS01510	COG0747	negative chemotaxis
ACAV_RS01530	COG0625	glutathione transferase activity
ACAV_RS01535	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ACAV_RS01580	COG1215	transferase activity, transferring glycosyl groups
ACAV_RS01600	COG0477	Major facilitator Superfamily
ACAV_RS01610	COG0745	RESPONSE REGULATOR receiver
ACAV_RS01615	COG2211	Major facilitator Superfamily
ACAV_RS01630	COG0501	Belongs to the peptidase M48B family
ACAV_RS01635	COG0471	metal ion transport
ACAV_RS01640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACAV_RS01655	COG2199	diguanylate cyclase activity
ACAV_RS01655	COG2203	Gaf domain
ACAV_RS01665	COG0583	DNA-binding transcription factor activity
ACAV_RS01670	COG2814	Major facilitator Superfamily
ACAV_RS01675	COG0656	L-ascorbic acid biosynthetic process
ACAV_RS01680	COG0708	Exodeoxyribonuclease III
ACAV_RS01685	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACAV_RS01695	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACAV_RS01710	COG0154	amidase activity
ACAV_RS01715	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACAV_RS01720	COG1077	Cell shape determining protein MreB Mrl
ACAV_RS01730	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ACAV_RS01735	COG0768	penicillin binding
ACAV_RS01750	COG0765	amino acid transport
ACAV_RS01755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACAV_RS01760	COG1760	l-serine dehydratase
ACAV_RS01780	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACAV_RS01785	COG1127	ABC transporter
ACAV_RS01830	COG0175	sulfate reduction
ACAV_RS01835	COG3237	CsbD-like
ACAV_RS01855	COG4452	Inner membrane protein CreD
ACAV_RS01860	COG2205	protein histidine kinase activity
ACAV_RS01865	COG0745	RESPONSE REGULATOR receiver
ACAV_RS01870	COG2095	MarC family integral membrane protein
ACAV_RS01875	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS01880	COG0412	Dienelactone hydrolase
ACAV_RS01890	COG1566	PFAM secretion protein HlyD family protein
ACAV_RS01905	COG0519	Catalyzes the synthesis of GMP from XMP
ACAV_RS01905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACAV_RS01910	COG0598	Magnesium transport protein CorA
ACAV_RS01920	COG1981	membrane
ACAV_RS01935	COG2945	thiolester hydrolase activity
ACAV_RS01940	COG1686	Belongs to the peptidase S11 family
ACAV_RS01945	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACAV_RS01950	COG0049	tRNA binding
ACAV_RS01955	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACAV_RS01960	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACAV_RS01965	COG0051	transcription antitermination factor activity, RNA binding
ACAV_RS01970	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACAV_RS01975	COG0088	Forms part of the polypeptide exit tunnel
ACAV_RS01980	COG0089	rRNA binding
ACAV_RS01985	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACAV_RS01990	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACAV_RS01995	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACAV_RS02000	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACAV_RS02005	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACAV_RS02010	COG0255	Belongs to the universal ribosomal protein uL29 family
ACAV_RS02015	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACAV_RS02020	COG0678	peroxiredoxin activity
ACAV_RS02030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACAV_RS02045	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACAV_RS02050	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACAV_RS02060	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ACAV_RS02065	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ACAV_RS02070	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ACAV_RS02075	COG2205	protein histidine kinase activity
ACAV_RS02080	COG0745	RESPONSE REGULATOR receiver
ACAV_RS02095	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACAV_RS02100	COG0321	lipoyl(octanoyl) transferase activity
ACAV_RS02105	COG2921	Belongs to the UPF0250 family
ACAV_RS02115	COG0356	it plays a direct role in the translocation of protons across the membrane
ACAV_RS02125	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ACAV_RS02130	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACAV_RS02135	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACAV_RS02140	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACAV_RS02145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ACAV_RS02150	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACAV_RS02155	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ACAV_RS02155	COG1793	dna ligase
ACAV_RS02160	COG1793	dna ligase
ACAV_RS02165	COG1201	RNA secondary structure unwinding
ACAV_RS02230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACAV_RS02235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACAV_RS02255	COG0121	glutamine amidotransferase
ACAV_RS02260	COG2814	Major facilitator Superfamily
ACAV_RS02265	COG1942	4-Oxalocrotonate Tautomerase
ACAV_RS02275	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ACAV_RS02305	COG0018	arginyl-trna synthetase
ACAV_RS02325	COG1137	ATPase activity
ACAV_RS02330	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ACAV_RS02335	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ACAV_RS02360	COG4178	(ABC) transporter
ACAV_RS02370	COG3318	Belongs to the UPF0149 family
ACAV_RS02370	COG3012	SEC-C Motif Domain Protein
ACAV_RS02375	COG0659	secondary active sulfate transmembrane transporter activity
ACAV_RS02390	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ACAV_RS02415	COG3181	Tripartite tricarboxylate transporter family receptor
ACAV_RS02430	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACAV_RS02445	COG2967	ApaG domain
ACAV_RS02450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ACAV_RS02460	COG0546	phosphoglycolate phosphatase activity
ACAV_RS02480	COG2207	Transcriptional regulator
ACAV_RS02500	COG4794	Type iii secretion
ACAV_RS02505	COG4790	Type iii secretion
ACAV_RS02520	COG4789	Type iii secretion
ACAV_RS02525	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACAV_RS02645	COG0500	methyltransferase
ACAV_RS02650	COG0741	lytic transglycosylase activity
ACAV_RS02650	COG0739	heme binding
ACAV_RS02650	COG1196	nuclear chromosome segregation
ACAV_RS02675	COG0512	Glutamine amidotransferase of anthranilate synthase
ACAV_RS02685	COG1280	lysine exporter protein (LysE YggA)
ACAV_RS02690	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACAV_RS02695	COG0134	indole-3-glycerol-phosphate synthase activity
ACAV_RS02700	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ACAV_RS02715	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ACAV_RS02745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ACAV_RS02755	COG0783	Belongs to the Dps family
ACAV_RS02760	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ACAV_RS02785	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACAV_RS02795	COG3842	ATPase activity
ACAV_RS02800	COG3842	ATPase activity
ACAV_RS02810	COG0395	ABC-type sugar transport system, permease component
ACAV_RS02830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACAV_RS02835	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ACAV_RS02840	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACAV_RS02845	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACAV_RS02850	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACAV_RS02855	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACAV_RS02860	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACAV_RS02865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACAV_RS02870	COG1841	ribosomal large subunit assembly
ACAV_RS02875	COG0200	Binds to the 23S rRNA
ACAV_RS02880	COG0201	protein transport
ACAV_RS02885	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACAV_RS02890	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ACAV_RS02895	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACAV_RS02900	COG0202	RNA polymerase activity
ACAV_RS02905	COG0203	ribosomal protein L17
ACAV_RS02915	COG0443	Heat shock 70 kDa protein
ACAV_RS02920	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ACAV_RS02925	COG0792	nuclease activity
ACAV_RS02930	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ACAV_RS02935	COG2823	Periplasmic or secreted lipoprotein
ACAV_RS02940	COG2084	Dehydrogenase
ACAV_RS02950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACAV_RS02960	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ACAV_RS02975	COG2733	membrane
ACAV_RS02995	COG0277	FAD linked oxidase domain protein
ACAV_RS03005	COG0583	DNA-binding transcription factor activity
ACAV_RS03025	COG1285	pathogenesis
ACAV_RS03035	COG3850	Histidine kinase
ACAV_RS03040	COG2197	response regulator
ACAV_RS03060	COG2223	nitrite transmembrane transporter activity
ACAV_RS03065	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ACAV_RS03070	COG1140	nitrate reductase beta subunit
ACAV_RS03075	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ACAV_RS03080	COG2181	nitrate reductase activity
ACAV_RS03085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACAV_RS03090	COG0288	reversible hydration of carbon dioxide
ACAV_RS03110	COG3945	hemerythrin HHE cation binding domain
ACAV_RS03120	COG0477	Major facilitator Superfamily
ACAV_RS03155	COG0583	DNA-binding transcription factor activity
ACAV_RS03195	COG1272	protein, Hemolysin III
ACAV_RS03260	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ACAV_RS03265	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ACAV_RS03275	COG0129	dihydroxy-acid dehydratase activity
ACAV_RS03280	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACAV_RS03290	COG0583	DNA-binding transcription factor activity
ACAV_RS03295	COG1741	Belongs to the pirin family
ACAV_RS03300	COG1335	isochorismatase
ACAV_RS03320	COG0243	molybdopterin cofactor binding
ACAV_RS03330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACAV_RS03335	COG1473	amidohydrolase
ACAV_RS03345	COG0840	transmembrane signaling receptor activity
ACAV_RS03360	COG0519	Catalyzes the synthesis of GMP from XMP
ACAV_RS03365	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACAV_RS03420	COG3409	Peptidoglycan-binding domain 1 protein
ACAV_RS03420	COG3267	Type II secretory pathway component ExeA
ACAV_RS03425	COG3266	domain, Protein
ACAV_RS03495	COG4269	membrane
ACAV_RS03530	COG1733	regulation of RNA biosynthetic process
ACAV_RS03535	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ACAV_RS03550	COG0625	glutathione transferase activity
ACAV_RS03555	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ACAV_RS03565	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ACAV_RS03570	COG1649	PFAM Uncharacterised BCR, COG1649
ACAV_RS03590	COG3447	MASE1 domain protein
ACAV_RS03590	COG5002	protein histidine kinase activity
ACAV_RS03590	COG5001	Diguanylate cyclase
ACAV_RS03595	COG0523	cobalamin synthesis protein
ACAV_RS03610	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ACAV_RS03615	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ACAV_RS03620	COG2001	Belongs to the MraZ family
ACAV_RS03625	COG0275	rRNA processing
ACAV_RS03640	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACAV_RS03645	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ACAV_RS03650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACAV_RS03655	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACAV_RS03660	COG0772	Belongs to the SEDS family
ACAV_RS03665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACAV_RS03670	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACAV_RS03675	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACAV_RS03680	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ACAV_RS03690	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACAV_RS03695	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ACAV_RS03700	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ACAV_RS03705	COG0840	transmembrane signaling receptor activity
ACAV_RS03720	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ACAV_RS03725	COG0575	Belongs to the CDS family
ACAV_RS03750	COG1414	Transcriptional regulator
ACAV_RS03755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACAV_RS03760	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACAV_RS03770	COG0557	exoribonuclease II activity
ACAV_RS03780	COG3150	esterase
ACAV_RS03785	COG0772	Belongs to the SEDS family
ACAV_RS03790	COG0154	amidase activity
ACAV_RS03795	COG0312	modulator of DNA gyrase
ACAV_RS03810	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ACAV_RS03820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACAV_RS03830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACAV_RS03835	COG0511	ligase activity, forming carbon-carbon bonds
ACAV_RS03840	COG0439	Biotin carboxylase
ACAV_RS03845	COG2264	protein methyltransferase activity
ACAV_RS03855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACAV_RS03865	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACAV_RS03900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ACAV_RS03910	COG2204	response regulator
ACAV_RS03920	COG2205	protein histidine kinase activity
ACAV_RS03925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACAV_RS03940	COG0456	acetyltransferase
ACAV_RS03965	COG1595	DNA-templated transcription, initiation
ACAV_RS03990	COG1538	Outer membrane efflux protein
ACAV_RS04025	COG0411	ABC transporter
ACAV_RS04035	COG0431	NADPH-dependent FMN reductase
ACAV_RS04050	COG3829	transcription factor binding
ACAV_RS04055	COG1024	Enoyl-CoA hydratase
ACAV_RS04070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACAV_RS04080	COG0012	GTP binding
ACAV_RS04100	COG1238	metal cluster binding
ACAV_RS04115	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ACAV_RS04120	COG0138	bifunctional purine biosynthesis protein purh
ACAV_RS04130	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACAV_RS04135	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ACAV_RS04135	COG0352	thiamine-phosphate diphosphorylase activity
ACAV_RS04135	COG0351	phosphomethylpyrimidine kinase
ACAV_RS04150	COG0835	chemotaxis
ACAV_RS04155	COG0840	transmembrane signaling receptor activity
ACAV_RS04160	COG0643	Histidine kinase
ACAV_RS04160	COG2198	Histidine kinase
ACAV_RS04165	COG0415	Belongs to the DNA photolyase family
ACAV_RS04170	COG1678	Uncharacterized ACR, COG1678
ACAV_RS04175	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ACAV_RS04180	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ACAV_RS04185	COG0540	Belongs to the ATCase OTCase family
ACAV_RS04210	COG2431	L-lysine efflux transmembrane transporter activity
ACAV_RS04215	COG3842	ATPase activity
ACAV_RS04220	COG1178	ABC-type Fe3 transport system permease component
ACAV_RS04270	COG2165	general secretion pathway protein
ACAV_RS04290	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ACAV_RS04295	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACAV_RS04300	COG1765	OsmC-like protein
ACAV_RS04305	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ACAV_RS04325	COG1473	amidohydrolase
ACAV_RS04330	COG0747	negative chemotaxis
ACAV_RS04335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACAV_RS04340	COG0444	Belongs to the ABC transporter superfamily
ACAV_RS04345	COG4608	Belongs to the ABC transporter superfamily
ACAV_RS04360	COG0840	transmembrane signaling receptor activity
ACAV_RS04370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACAV_RS04385	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ACAV_RS04390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACAV_RS04395	COG0166	Belongs to the GPI family
ACAV_RS04400	COG0840	transmembrane signaling receptor activity
ACAV_RS04410	COG1175	transmembrane transport
ACAV_RS04415	COG0395	ABC-type sugar transport system, permease component
ACAV_RS04425	COG0246	Mannitol dehydrogenase
ACAV_RS04435	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACAV_RS04445	COG4753	response regulator
ACAV_RS04445	COG2207	Transcriptional regulator
ACAV_RS04450	COG1070	Carbohydrate kinase
ACAV_RS04455	COG0459	protein refolding
ACAV_RS04460	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ACAV_RS04465	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACAV_RS04475	COG2192	nodulation
ACAV_RS04495	COG0463	Glycosyl transferase, family 2
ACAV_RS04515	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACAV_RS04565	COG0438	transferase activity, transferring glycosyl groups
ACAV_RS04570	COG0438	transferase activity, transferring glycosyl groups
ACAV_RS04580	COG1309	transcriptional regulator
ACAV_RS04585	COG0493	'glutamate synthase
ACAV_RS04595	COG1953	Uracil, thiamine, allantoin
ACAV_RS04630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACAV_RS04630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACAV_RS04635	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ACAV_RS04650	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ACAV_RS04660	COG1560	Kdo2-lipid A biosynthetic process
ACAV_RS04670	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ACAV_RS04680	COG1333	cytochrome c biogenesis protein
ACAV_RS04685	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACAV_RS04690	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACAV_RS04695	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ACAV_RS04710	COG1965	Belongs to the frataxin family
ACAV_RS04750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACAV_RS04755	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACAV_RS04760	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ACAV_RS04780	COG0069	glutamate synthase activity
ACAV_RS04780	COG0070	glutamate synthase
ACAV_RS04780	COG0067	glutamate synthase
ACAV_RS04790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACAV_RS04795	COG0765	amino acid transport
ACAV_RS04800	COG1126	abc transporter atp-binding protein
ACAV_RS04805	COG1127	ABC transporter
ACAV_RS04810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACAV_RS04815	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ACAV_RS04840	COG1131	(ABC) transporter
ACAV_RS04845	COG0842	Transport permease protein
ACAV_RS04850	COG5007	Belongs to the BolA IbaG family
ACAV_RS04855	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACAV_RS04860	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ACAV_RS04870	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACAV_RS04880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACAV_RS04895	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACAV_RS04900	COG0131	Imidazoleglycerol-phosphate dehydratase
ACAV_RS04910	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACAV_RS04930	COG0438	transferase activity, transferring glycosyl groups
ACAV_RS04960	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACAV_RS04965	COG1301	dicarboxylic acid transport
ACAV_RS04975	COG0107	imidazoleglycerol-phosphate synthase activity
ACAV_RS04980	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACAV_RS04985	COG0140	phosphoribosyl-ATP diphosphatase activity
ACAV_RS05000	COG0537	adenosine 5'-monophosphoramidase activity
ACAV_RS05005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACAV_RS05010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACAV_RS05015	COG0805	protein transport
ACAV_RS05070	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ACAV_RS05085	COG0714	Associated with various cellular activities
ACAV_RS05090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACAV_RS05095	COG0084	hydrolase, TatD family'
ACAV_RS05105	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ACAV_RS05110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACAV_RS05135	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS05150	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACAV_RS05160	COG1070	Carbohydrate kinase
ACAV_RS05175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACAV_RS05190	COG0829	nickel cation binding
ACAV_RS05210	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACAV_RS05225	COG3622	Belongs to the hyi family
ACAV_RS05245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACAV_RS05250	COG1116	anion transmembrane transporter activity
ACAV_RS05265	COG0280	phosphate acetyltransferase
ACAV_RS05265	COG0281	malic enzyme
ACAV_RS05270	COG2233	PERMEase
ACAV_RS05285	COG1953	Uracil, thiamine, allantoin
ACAV_RS05290	COG2186	Transcriptional regulator
ACAV_RS05295	COG0840	transmembrane signaling receptor activity
ACAV_RS05300	COG1301	dicarboxylic acid transport
ACAV_RS05335	COG1132	(ABC) transporter
ACAV_RS05360	COG0367	asparagine synthase
ACAV_RS05380	COG0438	transferase activity, transferring glycosyl groups
ACAV_RS05380	COG0297	glycogen (starch) synthase activity
ACAV_RS05385	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ACAV_RS05395	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACAV_RS05400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACAV_RS05415	COG2186	Transcriptional regulator
ACAV_RS05430	COG0405	Gamma-glutamyltransferase
ACAV_RS05470	COG0251	oxidation-reduction process
ACAV_RS05495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACAV_RS05495	COG2022	thiamine diphosphate biosynthetic process
ACAV_RS05500	COG5002	protein histidine kinase activity
ACAV_RS05500	COG3447	MASE1 domain protein
ACAV_RS05500	COG5001	Diguanylate cyclase
ACAV_RS05520	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACAV_RS05535	COG3845	ABC transporter
ACAV_RS05540	COG4603	Belongs to the binding-protein-dependent transport system permease family
ACAV_RS05555	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ACAV_RS05570	COG0583	DNA-binding transcription factor activity
ACAV_RS05575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACAV_RS05580	COG1126	abc transporter atp-binding protein
ACAV_RS05585	COG0765	amino acid transport
ACAV_RS05590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACAV_RS05610	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACAV_RS05620	COG2366	antibiotic biosynthetic process
ACAV_RS05625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACAV_RS05635	COG0402	S-adenosylhomocysteine deaminase activity
ACAV_RS05640	COG0717	Belongs to the dCTP deaminase family
ACAV_RS05655	COG2321	neutral zinc metallopeptidase
ACAV_RS05660	COG0513	Belongs to the DEAD box helicase family
ACAV_RS05665	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ACAV_RS05670	COG2916	Histone family protein nucleoid-structuring protein H-NS
ACAV_RS05675	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACAV_RS05680	COG5001	Diguanylate cyclase
ACAV_RS05695	COG3483	tryptophan 2,3-dioxygenase activity
ACAV_RS05705	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ACAV_RS05710	COG1522	sequence-specific DNA binding
ACAV_RS05715	COG0727	PFAM Uncharacterised protein family (UPF0153)
ACAV_RS05745	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACAV_RS05750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACAV_RS05760	COG0579	oxidoreductase
ACAV_RS05765	COG0268	Binds directly to 16S ribosomal RNA
ACAV_RS05770	COG0728	peptidoglycan biosynthetic process
ACAV_RS05780	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ACAV_RS05780	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ACAV_RS05790	COG3022	response to hydroperoxide
ACAV_RS05795	COG1530	ribonuclease E activity
ACAV_RS05805	COG0564	pseudouridine synthase activity
ACAV_RS05820	COG0616	signal peptide processing
ACAV_RS05820	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ACAV_RS05830	COG0424	maF-like protein
ACAV_RS05835	COG1399	metal-binding, possibly nucleic acid-binding protein
ACAV_RS05840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ACAV_RS05845	COG0416	fatty acid biosynthetic process
ACAV_RS05850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACAV_RS05860	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS05865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACAV_RS05870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACAV_RS05895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACAV_RS05900	COG0481	GTPase activity
ACAV_RS05915	COG0571	ribonuclease III activity
ACAV_RS05920	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACAV_RS05925	COG1381	Involved in DNA repair and RecF pathway recombination
ACAV_RS05930	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ACAV_RS05935	COG0736	holo-[acyl-carrier-protein] synthase activity
ACAV_RS05945	COG3064	Membrane
ACAV_RS05955	COG5001	Diguanylate cyclase
ACAV_RS05955	COG2203	Gaf domain
ACAV_RS05955	COG4251	negative regulation of phosphorylation
ACAV_RS05955	COG3706	GGDEF domain
ACAV_RS05960	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACAV_RS05980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACAV_RS05985	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACAV_RS05990	COG0438	transferase activity, transferring glycosyl groups
ACAV_RS06000	COG0762	integral membrane protein
ACAV_RS06005	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ACAV_RS06010	COG0159	tryptophan synthase activity
ACAV_RS06015	COG0133	tryptophan synthase activity
ACAV_RS06020	COG0135	phosphoribosylanthranilate isomerase activity
ACAV_RS06025	COG0101	tRNA pseudouridine synthase activity
ACAV_RS06035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ACAV_RS06045	COG0473	3-isopropylmalate dehydrogenase activity
ACAV_RS06050	COG0066	3-isopropylmalate dehydratase activity
ACAV_RS06060	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ACAV_RS06070	COG0484	heat shock protein binding
ACAV_RS06075	COG0443	Heat shock 70 kDa protein
ACAV_RS06080	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACAV_RS06085	COG0360	Binds together with S18 to 16S ribosomal RNA
ACAV_RS06095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACAV_RS06100	COG0359	binds to the 23S rRNA
ACAV_RS06120	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ACAV_RS06125	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACAV_RS06135	COG0436	Aminotransferase
ACAV_RS06150	COG1763	Mo-molybdopterin cofactor biosynthetic process
ACAV_RS06155	COG0303	'Molybdopterin
ACAV_RS06165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACAV_RS06190	COG0314	molybdopterin synthase activity
ACAV_RS06195	COG0542	response to heat
ACAV_RS06215	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ACAV_RS06225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACAV_RS06230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACAV_RS06240	COG0436	Aminotransferase
ACAV_RS06245	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACAV_RS06250	COG1185	polyribonucleotide nucleotidyltransferase activity
ACAV_RS06255	COG0604	alcohol dehydrogenase
ACAV_RS06255	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS06255	COG3321	synthase
ACAV_RS06260	COG0149	triose-phosphate isomerase activity
ACAV_RS06275	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACAV_RS06280	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACAV_RS06285	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACAV_RS06290	COG0649	NAD binding
ACAV_RS06295	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ACAV_RS06300	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ACAV_RS06305	COG1034	ATP synthesis coupled electron transport
ACAV_RS06310	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACAV_RS06315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACAV_RS06325	COG0713	ATP synthesis coupled electron transport
ACAV_RS06340	COG1007	ATP synthesis coupled electron transport
ACAV_RS06355	COG1132	(ABC) transporter
ACAV_RS06400	COG0457	Tetratricopeptide repeat
ACAV_RS06400	COG0463	Glycosyl transferase, family 2
ACAV_RS06420	COG0071	Belongs to the small heat shock protein (HSP20) family
ACAV_RS06425	COG1136	(ABC) transporter
ACAV_RS06425	COG0577	efflux transmembrane transporter activity
ACAV_RS06430	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ACAV_RS06435	COG0702	epimerase
ACAV_RS06440	COG1733	regulation of RNA biosynthetic process
ACAV_RS06445	COG2267	carboxylic ester hydrolase activity
ACAV_RS06450	COG0584	glycerophosphoryl diester phosphodiesterase
ACAV_RS06460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ACAV_RS06465	COG0586	Pfam SNARE associated Golgi protein
ACAV_RS06485	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACAV_RS06490	COG0802	atpase or kinase
ACAV_RS06495	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ACAV_RS06510	COG0540	Belongs to the ATCase OTCase family
ACAV_RS06525	COG4974	Belongs to the 'phage' integrase family
ACAV_RS06530	COG3181	Tripartite tricarboxylate transporter family receptor
ACAV_RS06535	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ACAV_RS06540	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ACAV_RS06545	COG2833	Protein of unknown function (DUF455)
ACAV_RS06555	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ACAV_RS06565	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ACAV_RS06570	COG0148	phosphopyruvate hydratase activity
ACAV_RS06580	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ACAV_RS06585	COG0504	CTP synthase activity
ACAV_RS06590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACAV_RS06595	COG0756	dUTP diphosphatase activity
ACAV_RS06605	COG1047	Peptidyl-prolyl cis-trans
ACAV_RS06610	COG2850	peptidyl-arginine hydroxylation
ACAV_RS06620	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ACAV_RS06625	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ACAV_RS06630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACAV_RS06635	COG2226	methyltransferase
ACAV_RS06650	COG0741	lytic transglycosylase activity
ACAV_RS06660	COG0840	transmembrane signaling receptor activity
ACAV_RS06665	COG0840	transmembrane signaling receptor activity
ACAV_RS06670	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ACAV_RS06700	COG2308	Evidence 4 Homologs of previously reported genes of
ACAV_RS06720	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ACAV_RS06730	COG4628	conserved protein (DUF2132)
ACAV_RS06735	COG2226	methyltransferase
ACAV_RS06750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACAV_RS06755	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS06795	COG0318	PFAM AMP-dependent synthetase and ligase
ACAV_RS06805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACAV_RS06810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACAV_RS06835	COG0657	acetylesterase activity
ACAV_RS06865	COG4774	siderophore transport
ACAV_RS06905	COG3634	alkyl hydroperoxide reductase activity
ACAV_RS06930	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ACAV_RS06945	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACAV_RS06970	COG0583	DNA-binding transcription factor activity
ACAV_RS06975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACAV_RS06980	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACAV_RS07000	COG0583	DNA-binding transcription factor activity
ACAV_RS07005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACAV_RS07015	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS07020	COG4948	Mandelate Racemase Muconate Lactonizing
ACAV_RS07060	COG0840	transmembrane signaling receptor activity
ACAV_RS07070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACAV_RS07080	COG5001	Diguanylate cyclase
ACAV_RS07080	COG3300	MHYT domain
ACAV_RS07085	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACAV_RS07090	COG0405	Gamma-glutamyltransferase
ACAV_RS07095	COG3540	Alkaline phosphatase
ACAV_RS07105	COG3321	synthase
ACAV_RS07105	COG0604	alcohol dehydrogenase
ACAV_RS07105	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS07110	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ACAV_RS07115	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ACAV_RS07125	COG0564	pseudouridine synthase activity
ACAV_RS07130	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ACAV_RS07135	COG1187	pseudouridine synthase activity
ACAV_RS07140	COG0105	UTP biosynthetic process
ACAV_RS07145	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACAV_RS07150	COG3063	Type IV pilus biogenesis stability protein PilW
ACAV_RS07160	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ACAV_RS07165	COG0124	histidyl-tRNA synthetase
ACAV_RS07180	COG1160	GTP binding
ACAV_RS07185	COG1923	regulation of RNA biosynthetic process
ACAV_RS07190	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ACAV_RS07195	COG0330	HflC and HflK could
ACAV_RS07200	COG0330	HflC and HflK could
ACAV_RS07205	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ACAV_RS07210	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACAV_RS07215	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ACAV_RS07245	COG1187	pseudouridine synthase activity
ACAV_RS07275	COG0174	glutamine synthetase
ACAV_RS07285	COG3852	Histidine kinase
ACAV_RS07300	COG0708	Exodeoxyribonuclease III
ACAV_RS07315	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ACAV_RS07325	COG0277	FAD linked oxidase domain protein
ACAV_RS07335	COG1295	ribonuclease BN
ACAV_RS07340	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ACAV_RS07345	COG1562	ergosterol biosynthetic process
ACAV_RS07365	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACAV_RS07370	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACAV_RS07375	COG0740	serine-type endopeptidase activity
ACAV_RS07380	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACAV_RS07390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACAV_RS07430	COG0631	protein serine/threonine phosphatase activity
ACAV_RS07445	COG2885	chlorophyll binding
ACAV_RS07510	COG1451	nucleotide metabolic process
ACAV_RS07515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACAV_RS07520	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ACAV_RS07525	COG2080	2 iron, 2 sulfur cluster binding
ACAV_RS07530	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ACAV_RS07545	COG0114	fumarate hydratase activity
ACAV_RS07555	COG0745	RESPONSE REGULATOR receiver
ACAV_RS07560	COG2205	protein histidine kinase activity
ACAV_RS07565	COG2113	Glycine betaine
ACAV_RS07570	COG4176	ABC-type proline glycine betaine transport system permease component
ACAV_RS07575	COG4175	Glycine betaine
ACAV_RS07585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACAV_RS07595	COG4654	Cytochrome c, class I
ACAV_RS07605	COG0129	dihydroxy-acid dehydratase activity
ACAV_RS07620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ACAV_RS07625	COG1802	Transcriptional regulator
ACAV_RS07645	COG0318	PFAM AMP-dependent synthetase and ligase
ACAV_RS07650	COG0583	DNA-binding transcription factor activity
ACAV_RS07655	COG1228	amidohydrolase
ACAV_RS07685	COG0589	response to stress
ACAV_RS07690	COG2217	Heavy metal translocating P-type atpase
ACAV_RS07700	COG3278	Belongs to the heme-copper respiratory oxidase family
ACAV_RS07735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACAV_RS07740	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACAV_RS07750	COG3437	response regulator, receiver
ACAV_RS07770	COG4206	TonB-dependent receptor
ACAV_RS07775	COG1797	cobyrinic acid a,c-diamide synthase activity
ACAV_RS07790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACAV_RS07795	COG1121	(ABC) transporter
ACAV_RS07800	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ACAV_RS07805	COG0778	Nitroreductase
ACAV_RS07830	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS07835	COG1492	cobalamin metabolic process
ACAV_RS07840	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ACAV_RS07865	COG1176	ABC-type spermidine putrescine transport system, permease component I
ACAV_RS07870	COG3833	ABC-type maltose transport systems, permease component
ACAV_RS07890	COG0477	Major facilitator Superfamily
ACAV_RS07905	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ACAV_RS07910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACAV_RS07915	COG2900	Belongs to the SlyX family
ACAV_RS07920	COG0667	Aldo Keto reductase
ACAV_RS07930	COG0513	Belongs to the DEAD box helicase family
ACAV_RS07955	COG1959	2 iron, 2 sulfur cluster binding
ACAV_RS07960	COG3386	PFAM SMP-30 Gluconolaconase
ACAV_RS07985	COG0583	DNA-binding transcription factor activity
ACAV_RS08000	COG0560	Phosphoserine phosphatase
ACAV_RS08010	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ACAV_RS08020	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ACAV_RS08025	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACAV_RS08025	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACAV_RS08030	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACAV_RS08030	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACAV_RS08050	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS08060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACAV_RS08070	COG0582	viral genome integration into host DNA
ACAV_RS08090	COG4774	siderophore transport
ACAV_RS08095	COG0840	transmembrane signaling receptor activity
ACAV_RS08130	COG0693	protein deglycase activity
ACAV_RS08140	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
ACAV_RS08150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACAV_RS08155	COG2721	sulfolactate sulfo-lyase activity
ACAV_RS08160	COG3254	rhamnose metabolic process
ACAV_RS08165	COG0246	Mannitol dehydrogenase
ACAV_RS08170	COG1063	alcohol dehydrogenase
ACAV_RS08190	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACAV_RS08195	COG1129	ABC transporter
ACAV_RS08210	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS08215	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACAV_RS08235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACAV_RS08245	COG1914	H( )-stimulated, divalent metal cation uptake system
ACAV_RS08275	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACAV_RS08290	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACAV_RS08295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACAV_RS08315	COG1446	asparaginase
ACAV_RS08320	COG4172	Belongs to the ABC transporter superfamily
ACAV_RS08330	COG0601	transmembrane transport
ACAV_RS08335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACAV_RS08355	COG0322	excinuclease ABC activity
ACAV_RS08375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACAV_RS08385	COG3181	Tripartite tricarboxylate transporter family receptor
ACAV_RS08390	COG0165	Argininosuccinate lyase
ACAV_RS08395	COG0583	DNA-binding transcription factor activity
ACAV_RS08405	COG0024	Methionine aminopeptidase
ACAV_RS08415	COG3181	Tripartite tricarboxylate transporter family receptor
ACAV_RS08420	COG0028	Belongs to the TPP enzyme family
ACAV_RS08425	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS08445	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACAV_RS08455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACAV_RS08495	COG3038	cytochrome b561
ACAV_RS08500	COG1012	belongs to the aldehyde dehydrogenase family
ACAV_RS08515	COG0840	transmembrane signaling receptor activity
ACAV_RS08520	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACAV_RS08550	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACAV_RS08550	COG4651	solute:proton antiporter activity
ACAV_RS08560	COG0513	Belongs to the DEAD box helicase family
ACAV_RS08565	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACAV_RS08570	COG0488	(ABC) transporter
ACAV_RS08585	COG3191	aminopeptidase activity
ACAV_RS08620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACAV_RS08635	COG2132	Multicopper oxidase
ACAV_RS08660	COG2217	Heavy metal translocating P-type atpase
ACAV_RS08665	COG0789	Transcriptional regulator
ACAV_RS08690	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACAV_RS08690	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ACAV_RS08695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACAV_RS08700	COG0052	Belongs to the universal ribosomal protein uS2 family
ACAV_RS08705	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACAV_RS08710	COG0528	UMP kinase activity
ACAV_RS08715	COG0233	cytoplasmic translational termination
ACAV_RS08720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACAV_RS08725	COG0575	Belongs to the CDS family
ACAV_RS08730	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ACAV_RS08735	COG0750	zinc metalloprotease
ACAV_RS08750	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACAV_RS08755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACAV_RS08760	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACAV_RS08765	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACAV_RS08770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACAV_RS08775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACAV_RS08790	COG4774	siderophore transport
ACAV_RS08810	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ACAV_RS08815	COG0308	aminopeptidase N
ACAV_RS08830	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACAV_RS08845	COG0667	Aldo Keto reductase
ACAV_RS08850	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ACAV_RS08855	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ACAV_RS08865	COG3577	Aspartyl protease
ACAV_RS08870	COG1666	GTP binding
ACAV_RS08880	COG0137	argininosuccinate synthase activity
ACAV_RS08885	COG3123	guanosine phosphorylase activity
ACAV_RS08895	COG1393	Belongs to the ArsC family
ACAV_RS08900	COG0285	dihydrofolate synthase activity
ACAV_RS08910	COG1286	toxin biosynthetic process
ACAV_RS08925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACAV_RS08965	COG2814	Major facilitator Superfamily
ACAV_RS08970	COG2814	Major facilitator Superfamily
ACAV_RS08985	COG2183	response to ionizing radiation
ACAV_RS09000	COG1454	alcohol dehydrogenase
ACAV_RS09010	COG0657	acetylesterase activity
ACAV_RS09025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ACAV_RS09030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACAV_RS09045	COG0084	hydrolase, TatD family'
ACAV_RS09055	COG1132	(ABC) transporter
ACAV_RS09060	COG0823	Involved in the tonB-independent uptake of proteins
ACAV_RS09075	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ACAV_RS09100	COG2423	ornithine cyclodeaminase activity
ACAV_RS09135	COG5001	Diguanylate cyclase
ACAV_RS09135	COG4251	negative regulation of phosphorylation
ACAV_RS09135	COG3706	GGDEF domain
ACAV_RS09135	COG2203	Gaf domain
ACAV_RS09170	COG2010	Cytochrome c
ACAV_RS09170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACAV_RS09180	COG0779	Required for maturation of 30S ribosomal subunits
ACAV_RS09185	COG2251	uridine kinase activity
ACAV_RS09185	COG0195	Participates in both transcription termination and antitermination
ACAV_RS09190	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACAV_RS09195	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACAV_RS09200	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACAV_RS09210	COG1253	flavin adenine dinucleotide binding
ACAV_RS09215	COG1024	Enoyl-CoA hydratase
ACAV_RS09235	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACAV_RS09240	COG2867	negative regulation of translational initiation
ACAV_RS09245	COG2914	Belongs to the UPF0125 (RnfH) family
ACAV_RS09270	COG0519	Catalyzes the synthesis of GMP from XMP
ACAV_RS09270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACAV_RS09275	COG0582	viral genome integration into host DNA
ACAV_RS09320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACAV_RS09325	COG0583	DNA-binding transcription factor activity
ACAV_RS09335	COG1566	PFAM secretion protein HlyD family protein
ACAV_RS09345	COG1289	transmembrane transporter activity
ACAV_RS09370	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ACAV_RS09375	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS09380	COG4221	oxidoreductase activity
ACAV_RS09405	COG2207	Transcriptional regulator
ACAV_RS09425	COG1309	transcriptional regulator
ACAV_RS09450	COG2226	methyltransferase
ACAV_RS09465	COG5002	protein histidine kinase activity
ACAV_RS09470	COG0494	nUDIX hydrolase
ACAV_RS09505	COG3181	Tripartite tricarboxylate transporter family receptor
ACAV_RS09515	COG0625	glutathione transferase activity
ACAV_RS09535	COG4774	siderophore transport
ACAV_RS09540	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ACAV_RS09550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACAV_RS09560	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ACAV_RS09560	COG0506	proline dehydrogenase activity
ACAV_RS09560	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ACAV_RS09580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACAV_RS09590	COG0670	Belongs to the BI1 family
ACAV_RS09595	COG3193	protein, possibly involved in utilization of glycolate and propanediol
ACAV_RS09635	COG0405	Gamma-glutamyltransferase
ACAV_RS09640	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ACAV_RS09670	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACAV_RS09705	COG2212	antiporter activity
ACAV_RS09715	COG0651	ATP synthesis coupled electron transport
ACAV_RS09720	COG1006	Multisubunit Na H antiporter MnhC subunit
ACAV_RS09725	COG2111	Na H antiporter
ACAV_RS09725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACAV_RS09730	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ACAV_RS09740	COG0776	regulation of translation
ACAV_RS09750	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACAV_RS09755	COG0287	Prephenate dehydrogenase
ACAV_RS09760	COG0077	Prephenate dehydratase
ACAV_RS09760	COG1605	Chorismate mutase
ACAV_RS09765	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ACAV_RS09780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACAV_RS09820	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ACAV_RS09835	COG0583	DNA-binding transcription factor activity
ACAV_RS09860	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ACAV_RS09870	COG4166	transmembrane transport
ACAV_RS09875	COG4174	ABC transporter (Permease)
ACAV_RS09880	COG4239	(ABC) transporter, permease
ACAV_RS09885	COG4172	Belongs to the ABC transporter superfamily
ACAV_RS09890	COG5002	protein histidine kinase activity
ACAV_RS09890	COG3447	MASE1 domain protein
ACAV_RS09890	COG5001	Diguanylate cyclase
ACAV_RS09895	COG0628	permease
ACAV_RS09900	COG0567	Dehydrogenase, E1 component
ACAV_RS09905	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACAV_RS09910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACAV_RS09915	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ACAV_RS09930	COG1199	ATP-dependent helicase activity
ACAV_RS09945	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ACAV_RS09950	COG0542	response to heat
ACAV_RS09965	COG2951	lytic endotransglycosylase activity
ACAV_RS09970	COG2925	Exonuclease
ACAV_RS09980	COG3284	Transcriptional regulator
ACAV_RS10000	COG1012	belongs to the aldehyde dehydrogenase family
ACAV_RS10005	COG0484	heat shock protein binding
ACAV_RS10050	COG0402	S-adenosylhomocysteine deaminase activity
ACAV_RS10070	COG1079	Belongs to the binding-protein-dependent transport system permease family
ACAV_RS10075	COG4603	Belongs to the binding-protein-dependent transport system permease family
ACAV_RS10080	COG3845	ABC transporter
ACAV_RS10085	COG1744	ABC transporter substrate-binding protein PnrA-like
ACAV_RS10125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ACAV_RS10145	COG0583	DNA-binding transcription factor activity
ACAV_RS10150	COG0625	glutathione transferase activity
ACAV_RS10155	COG0433	COG0433 Predicted ATPase
ACAV_RS10160	COG0217	transcriptional regulatory protein
ACAV_RS10165	COG0151	Belongs to the GarS family
ACAV_RS10170	COG0408	coproporphyrinogen oxidase activity
ACAV_RS10175	COG0799	negative regulation of ribosome biogenesis
ACAV_RS10180	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ACAV_RS10190	COG0424	maF-like protein
ACAV_RS10195	COG1530	ribonuclease E activity
ACAV_RS10235	COG2205	protein histidine kinase activity
ACAV_RS10240	COG0596	Alpha beta hydrolase
ACAV_RS10255	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS10265	COG1024	Enoyl-CoA hydratase
ACAV_RS10270	COG1960	acyl-CoA dehydrogenase activity
ACAV_RS10280	COG0683	leucine binding
ACAV_RS10315	COG0436	Aminotransferase
ACAV_RS10320	COG0583	DNA-binding transcription factor activity
ACAV_RS10340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACAV_RS10365	COG0372	Belongs to the citrate synthase family
ACAV_RS10370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACAV_RS10375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACAV_RS10380	COG0318	PFAM AMP-dependent synthetase and ligase
ACAV_RS10395	COG0589	response to stress
ACAV_RS10405	COG3158	transport of potassium into the cell
ACAV_RS10415	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS10420	COG0564	pseudouridine synthase activity
ACAV_RS10435	COG0789	Transcriptional regulator
ACAV_RS10440	COG0545	Peptidyl-prolyl cis-trans isomerase
ACAV_RS10445	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACAV_RS10445	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACAV_RS10450	COG0509	glycine decarboxylation via glycine cleavage system
ACAV_RS10455	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACAV_RS10470	COG4120	Belongs to the binding-protein-dependent transport system permease family
ACAV_RS10500	COG0367	asparagine synthase
ACAV_RS10505	COG1012	belongs to the aldehyde dehydrogenase family
ACAV_RS10510	COG0730	response to heat
ACAV_RS10535	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS10605	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACAV_RS10610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACAV_RS10635	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ACAV_RS10645	COG1252	NADH dehydrogenase
ACAV_RS10670	COG0835	chemotaxis
ACAV_RS10680	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACAV_RS10680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACAV_RS10685	COG0347	Belongs to the P(II) protein family
ACAV_RS10695	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ACAV_RS10715	COG1595	DNA-templated transcription, initiation
ACAV_RS10720	COG0028	Belongs to the TPP enzyme family
ACAV_RS10725	COG0440	acetolactate synthase activity
ACAV_RS10730	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ACAV_RS10735	COG1183	phosphatidylcholine synthase activity
ACAV_RS10740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACAV_RS10750	COG1414	Transcriptional regulator
ACAV_RS10755	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ACAV_RS10760	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ACAV_RS10775	COG2832	Protein of unknown function (DUF454)
ACAV_RS10780	COG0242	peptide deformylase activity
ACAV_RS10785	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ACAV_RS10790	COG0024	Methionine aminopeptidase
ACAV_RS10795	COG0047	phosphoribosylformylglycinamidine synthase activity
ACAV_RS10795	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACAV_RS10805	COG3300	MHYT domain
ACAV_RS10805	COG5001	Diguanylate cyclase
ACAV_RS10810	COG2354	Protein conserved in bacteria
ACAV_RS10815	COG3047	cAMP biosynthetic process
ACAV_RS10830	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
ACAV_RS10835	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACAV_RS10845	COG0826	peptidase U32
ACAV_RS10870	COG1619	proteins homologs of microcin C7 resistance protein MccF
ACAV_RS10885	COG1960	acyl-CoA dehydrogenase activity
ACAV_RS10900	COG1024	Enoyl-CoA hydratase
ACAV_RS10905	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACAV_RS10920	COG2022	thiamine diphosphate biosynthetic process
ACAV_RS10935	COG0351	phosphomethylpyrimidine kinase
ACAV_RS10980	COG0492	ferredoxin-NADP+ reductase activity
ACAV_RS10985	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ACAV_RS10990	COG2895	sulfate adenylyltransferase (ATP) activity
ACAV_RS10990	COG0529	Catalyzes the synthesis of activated sulfate
ACAV_RS11010	COG0730	response to heat
ACAV_RS11025	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ACAV_RS11025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACAV_RS11030	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ACAV_RS11040	COG0431	NADPH-dependent FMN reductase
ACAV_RS11045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ACAV_RS11055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACAV_RS11065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACAV_RS11070	COG1116	anion transmembrane transporter activity
ACAV_RS11080	COG0583	DNA-binding transcription factor activity
ACAV_RS11100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACAV_RS11110	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ACAV_RS11115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACAV_RS11125	COG0583	DNA-binding transcription factor activity
ACAV_RS11130	COG1741	Belongs to the pirin family
ACAV_RS11140	COG1741	Belongs to the pirin family
ACAV_RS11145	COG1054	Belongs to the UPF0176 family
ACAV_RS11185	COG4181	ATPase activity
ACAV_RS11190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACAV_RS11195	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACAV_RS11200	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACAV_RS11205	COG0667	Aldo Keto reductase
ACAV_RS11225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACAV_RS11265	COG4178	(ABC) transporter
ACAV_RS11270	COG4774	siderophore transport
ACAV_RS11280	COG0642	Histidine kinase
ACAV_RS11290	COG3181	Tripartite tricarboxylate transporter family receptor
ACAV_RS11340	COG5002	protein histidine kinase activity
ACAV_RS11345	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACAV_RS11350	COG1011	Hydrolase
ACAV_RS11355	COG2267	carboxylic ester hydrolase activity
ACAV_RS11365	COG0517	IMP dehydrogenase activity
ACAV_RS11365	COG1125	glycine betaine transport
ACAV_RS11370	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACAV_RS11380	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACAV_RS11385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACAV_RS11390	COG0741	lytic transglycosylase activity
ACAV_RS11415	COG0557	exoribonuclease II activity
ACAV_RS11420	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS11430	COG0297	glycogen (starch) synthase activity
ACAV_RS11450	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ACAV_RS11455	COG2205	protein histidine kinase activity
ACAV_RS11455	COG0784	Response regulator, receiver
ACAV_RS11475	COG2205	protein histidine kinase activity
ACAV_RS11480	COG2205	protein histidine kinase activity
ACAV_RS11490	COG2172	sigma factor antagonist activity
ACAV_RS11495	COG1366	Belongs to the anti-sigma-factor antagonist family
ACAV_RS11500	COG1366	Belongs to the anti-sigma-factor antagonist family
ACAV_RS11510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACAV_RS11520	COG2188	Transcriptional regulator
ACAV_RS11525	COG2986	histidine ammonia-lyase
ACAV_RS11530	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ACAV_RS11545	COG1228	amidohydrolase
ACAV_RS11560	COG5006	permease, DMT superfamily
ACAV_RS11575	COG0688	phosphatidylethanolamine metabolic process
ACAV_RS11580	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACAV_RS11600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACAV_RS11610	COG2917	probably involved in intracellular septation
ACAV_RS11615	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACAV_RS11620	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ACAV_RS11625	COG0318	PFAM AMP-dependent synthetase and ligase
ACAV_RS11635	COG0559	Belongs to the binding-protein-dependent transport system permease family
ACAV_RS11645	COG0411	ABC transporter
ACAV_RS11670	COG3706	GGDEF domain
ACAV_RS11685	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACAV_RS11685	COG1024	Enoyl-CoA hydratase
ACAV_RS11690	COG0183	Belongs to the thiolase family
ACAV_RS11695	COG2050	protein possibly involved in aromatic compounds catabolism
ACAV_RS11700	COG1960	acyl-CoA dehydrogenase activity
ACAV_RS11715	COG2130	NADP-dependent
ACAV_RS11720	COG2153	protein acetylation
ACAV_RS11740	COG1840	ABC-type Fe3 transport system, periplasmic component
ACAV_RS11750	COG0697	spore germination
ACAV_RS11755	COG1522	sequence-specific DNA binding
ACAV_RS11770	COG2224	Isocitrate lyase
ACAV_RS11775	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACAV_RS11780	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ACAV_RS11785	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ACAV_RS11790	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACAV_RS11795	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACAV_RS11800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACAV_RS11800	COG0072	phenylalanine-tRNA ligase activity
ACAV_RS11805	COG0776	regulation of translation
ACAV_RS11810	COG0789	Transcriptional regulator
ACAV_RS11830	COG1132	(ABC) transporter
ACAV_RS11835	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ACAV_RS11845	COG1742	UPF0060 membrane protein
ACAV_RS11855	COG1196	nuclear chromosome segregation
ACAV_RS11865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACAV_RS11880	COG3209	COG3209 Rhs family protein
ACAV_RS11925	COG0791	NLP P60 protein
ACAV_RS11930	COG2133	pyrroloquinoline quinone binding
ACAV_RS11955	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACAV_RS11955	COG1902	pentaerythritol trinitrate reductase activity
ACAV_RS11980	COG2169	Transcriptional regulator
ACAV_RS12005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACAV_RS12040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACAV_RS12040	COG0045	succinate-CoA ligase (ADP-forming) activity
ACAV_RS12040	COG1042	CoA-binding domain protein
ACAV_RS12060	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ACAV_RS12065	COG1309	transcriptional regulator
ACAV_RS12070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACAV_RS12080	COG0577	efflux transmembrane transporter activity
ACAV_RS12080	COG1136	(ABC) transporter
ACAV_RS12105	COG4206	TonB-dependent receptor
ACAV_RS12110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACAV_RS12120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACAV_RS12130	COG0793	Belongs to the peptidase S41A family
ACAV_RS12145	COG0259	pyridoxamine-phosphate oxidase activity
ACAV_RS12175	COG1609	Transcriptional regulator
ACAV_RS12180	COG3265	gluconokinase activity
ACAV_RS12185	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ACAV_RS12190	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ACAV_RS12195	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACAV_RS12205	COG0800	Aldolase
ACAV_RS12215	COG0346	lactoylglutathione lyase activity
ACAV_RS12220	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS12250	COG0583	DNA-binding transcription factor activity
ACAV_RS12260	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ACAV_RS12325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACAV_RS12330	COG4166	transmembrane transport
ACAV_RS12340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACAV_RS12370	COG0583	DNA-binding transcription factor activity
ACAV_RS12385	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACAV_RS12415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACAV_RS12425	COG1696	Membrane protein involved in D-alanine export
ACAV_RS12445	COG1215	transferase activity, transferring glycosyl groups
ACAV_RS12455	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ACAV_RS12470	COG0564	pseudouridine synthase activity
ACAV_RS12475	COG2982	Protein involved in outer membrane biogenesis
ACAV_RS12480	COG0587	DNA-directed DNA polymerase activity
ACAV_RS12495	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ACAV_RS12500	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ACAV_RS12525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACAV_RS12580	COG0644	oxidoreductase
ACAV_RS12595	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACAV_RS12600	COG0746	molybdenum cofactor guanylyltransferase activity
ACAV_RS12610	COG0303	'Molybdopterin
ACAV_RS12620	COG0328	RNA-DNA hybrid ribonuclease activity
ACAV_RS12625	COG2226	methyltransferase
ACAV_RS12630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACAV_RS12635	COG1388	LysM domain
ACAV_RS12635	COG0741	lytic transglycosylase activity
ACAV_RS12650	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ACAV_RS12655	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ACAV_RS12660	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ACAV_RS12670	COG2081	HI0933 family
ACAV_RS12675	COG1074	ATP-dependent DNA helicase activity
ACAV_RS12690	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ACAV_RS12695	COG0419	ATPase involved in DNA repair
ACAV_RS12700	COG0420	3'-5' exonuclease activity
ACAV_RS12705	COG0254	rRNA binding
ACAV_RS12715	COG0534	Mate efflux family protein
ACAV_RS12730	COG0704	Plays a role in the regulation of phosphate uptake
ACAV_RS12735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACAV_RS12740	COG0581	inorganic phosphate transmembrane transporter activity
ACAV_RS12745	COG0573	inorganic phosphate transmembrane transporter activity
ACAV_RS12750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ACAV_RS12755	COG0248	Ppx GppA phosphatase
ACAV_RS12785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACAV_RS12795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACAV_RS12800	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ACAV_RS12805	COG1534	Rna-binding protein
ACAV_RS12820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACAV_RS12825	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ACAV_RS12830	COG0505	Belongs to the CarA family
ACAV_RS12840	COG1113	amino acid transport
ACAV_RS12870	COG1960	acyl-CoA dehydrogenase activity
ACAV_RS12885	COG2032	superoxide dismutase activity
ACAV_RS12890	COG4772	TonB-dependent receptor
ACAV_RS12905	COG2721	sulfolactate sulfo-lyase activity
ACAV_RS12920	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACAV_RS12930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACAV_RS12940	COG3181	Tripartite tricarboxylate transporter family receptor
ACAV_RS12945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACAV_RS12980	COG2814	Major facilitator Superfamily
ACAV_RS12990	COG0840	transmembrane signaling receptor activity
ACAV_RS13020	COG0745	RESPONSE REGULATOR receiver
ACAV_RS13065	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ACAV_RS13070	COG1570	exodeoxyribonuclease VII activity
ACAV_RS13075	COG0811	peptide transport
ACAV_RS13080	COG0848	biopolymer transport protein
ACAV_RS13085	COG1663	tetraacyldisaccharide 4'-kinase activity
ACAV_RS13090	COG2835	tetraacyldisaccharide 4'-kinase activity
ACAV_RS13095	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ACAV_RS13100	COG0563	adenylate kinase activity
ACAV_RS13105	COG0252	asparaginase activity
ACAV_RS13110	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACAV_RS13120	COG1643	Atp-dependent helicase
ACAV_RS13130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACAV_RS13135	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACAV_RS13135	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ACAV_RS13150	COG1054	Belongs to the UPF0176 family
ACAV_RS13155	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ACAV_RS13160	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ACAV_RS13165	COG4208	sulfate ABC transporter
ACAV_RS13170	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ACAV_RS13175	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ACAV_RS13195	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ACAV_RS13210	COG0840	transmembrane signaling receptor activity
ACAV_RS13230	COG2011	ABC-type metal ion transport system permease component
ACAV_RS13235	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACAV_RS13245	COG2814	Major facilitator Superfamily
ACAV_RS13250	COG0583	DNA-binding transcription factor activity
ACAV_RS13260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACAV_RS13275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACAV_RS13290	COG5002	protein histidine kinase activity
ACAV_RS13310	COG0583	DNA-binding transcription factor activity
ACAV_RS13350	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACAV_RS13365	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACAV_RS13370	COG1737	Transcriptional regulator
ACAV_RS13385	COG4770	biotin carboxylase activity
ACAV_RS13395	COG4770	biotin carboxylase activity
ACAV_RS13400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACAV_RS13405	COG1703	isobutyryl-CoA mutase activity
ACAV_RS13415	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACAV_RS13415	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACAV_RS13420	COG1802	Transcriptional regulator
ACAV_RS13470	COG0840	transmembrane signaling receptor activity
ACAV_RS13475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACAV_RS13495	COG2878	Part of a membrane complex involved in electron transport
ACAV_RS13500	COG0840	transmembrane signaling receptor activity
ACAV_RS13510	COG2171	N-acyltransferase activity
ACAV_RS13520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACAV_RS13525	COG2890	protein-(glutamine-N5) methyltransferase activity
ACAV_RS13530	COG0488	(ABC) transporter
ACAV_RS13535	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS13540	COG0183	Belongs to the thiolase family
ACAV_RS13545	COG3243	poly(R)-hydroxyalkanoic acid synthase
ACAV_RS13575	COG0515	serine threonine protein kinase
ACAV_RS13595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACAV_RS13605	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ACAV_RS13630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACAV_RS13635	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACAV_RS13640	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ACAV_RS13650	COG4566	intracellular signal transduction
ACAV_RS13655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACAV_RS13670	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ACAV_RS13675	COG0167	dihydroorotate dehydrogenase activity
ACAV_RS13695	COG0579	oxidoreductase
ACAV_RS13720	COG0633	Ferredoxin
ACAV_RS13725	COG0443	Heat shock 70 kDa protein
ACAV_RS13730	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ACAV_RS13740	COG0822	iron-sulfur transferase activity
ACAV_RS13745	COG1104	cysteine desulfurase activity
ACAV_RS13750	COG1959	2 iron, 2 sulfur cluster binding
ACAV_RS13755	COG0556	nucleotide-excision repair
ACAV_RS13765	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACAV_RS13780	COG0840	transmembrane signaling receptor activity
ACAV_RS13795	COG1739	Uncharacterized protein family UPF0029
ACAV_RS13815	COG0154	amidase activity
ACAV_RS13820	COG3181	Tripartite tricarboxylate transporter family receptor
ACAV_RS13825	COG3048	D-serine ammonia-lyase activity
ACAV_RS13840	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ACAV_RS13905	COG0527	aspartate kinase activity
ACAV_RS13910	COG0037	tRNA processing
ACAV_RS13925	COG0215	cysteine-tRNA ligase activity
ACAV_RS13995	COG1522	sequence-specific DNA binding
ACAV_RS14015	COG3384	dioxygenase
ACAV_RS14030	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ACAV_RS14040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACAV_RS14045	COG1950	PFAM Membrane protein of
ACAV_RS14060	COG0765	amino acid transport
ACAV_RS14065	COG0765	amino acid transport
ACAV_RS14070	COG1126	abc transporter atp-binding protein
ACAV_RS14095	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS14100	COG0583	DNA-binding transcription factor activity
ACAV_RS14140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACAV_RS14170	COG0840	transmembrane signaling receptor activity
ACAV_RS14200	COG0564	pseudouridine synthase activity
ACAV_RS14205	COG1285	pathogenesis
ACAV_RS14220	COG2814	Major facilitator Superfamily
ACAV_RS14240	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ACAV_RS14255	COG5002	protein histidine kinase activity
ACAV_RS14265	COG0028	Belongs to the TPP enzyme family
ACAV_RS14270	COG2918	glutathione biosynthetic process
ACAV_RS14285	COG3386	PFAM SMP-30 Gluconolaconase
ACAV_RS14305	COG1879	ABC-type sugar transport system periplasmic component
ACAV_RS14310	COG4213	ABC transporter substrate-binding protein
ACAV_RS14320	COG4214	carbohydrate transport
ACAV_RS14330	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACAV_RS14335	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACAV_RS14350	COG3734	2-keto-3-deoxy-galactonokinase
ACAV_RS14355	COG0800	Aldolase
ACAV_RS14360	COG4948	Mandelate Racemase Muconate Lactonizing
ACAV_RS14365	COG1289	transmembrane transporter activity
ACAV_RS14375	COG0840	transmembrane signaling receptor activity
ACAV_RS14385	COG2201	protein-glutamate methylesterase activity
ACAV_RS14390	COG0745	RESPONSE REGULATOR receiver
ACAV_RS14400	COG2205	protein histidine kinase activity
ACAV_RS14400	COG2202	Pas domain
ACAV_RS14410	COG0633	Ferredoxin
ACAV_RS14425	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACAV_RS14430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACAV_RS14435	COG0436	Aminotransferase
ACAV_RS14440	COG0824	Thioesterase
ACAV_RS14470	COG0477	Major facilitator Superfamily
ACAV_RS14475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ACAV_RS14480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACAV_RS14485	COG1845	cytochrome c oxidase, subunit III
ACAV_RS14490	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ACAV_RS14505	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ACAV_RS14520	COG0826	peptidase U32
ACAV_RS14535	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
ACAV_RS14540	COG1049	propionate catabolic process, 2-methylcitrate cycle
ACAV_RS14555	COG4106	trans-aconitate 2-methyltransferase activity
ACAV_RS14560	COG0039	L-malate dehydrogenase activity
ACAV_RS14565	COG2188	Transcriptional regulator
ACAV_RS14580	COG1053	succinate dehydrogenase
ACAV_RS14585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACAV_RS14590	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ACAV_RS14595	COG0372	Belongs to the citrate synthase family
ACAV_RS14605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACAV_RS14610	COG4977	sequence-specific DNA binding
ACAV_RS14620	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ACAV_RS14625	COG2194	sulfuric ester hydrolase activity
ACAV_RS14635	COG0840	transmembrane signaling receptor activity
ACAV_RS14645	COG0473	3-isopropylmalate dehydrogenase activity
ACAV_RS14655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACAV_RS14660	COG0601	transmembrane transport
ACAV_RS14670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACAV_RS14695	COG1522	sequence-specific DNA binding
ACAV_RS14700	COG1473	amidohydrolase
ACAV_RS14740	COG1960	acyl-CoA dehydrogenase activity
ACAV_RS14755	COG3264	Mechanosensitive ion channel
ACAV_RS14755	COG1511	domain protein
ACAV_RS14760	COG1024	Enoyl-CoA hydratase
ACAV_RS14765	COG0123	including yeast histone deacetylase and acetoin utilization protein
ACAV_RS14770	COG0714	Associated with various cellular activities
ACAV_RS14785	COG2951	lytic endotransglycosylase activity
ACAV_RS14800	COG3268	Saccharopine dehydrogenase
ACAV_RS14805	COG0318	PFAM AMP-dependent synthetase and ligase
ACAV_RS14840	COG0683	leucine binding
ACAV_RS14855	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACAV_RS14860	COG0683	leucine binding
ACAV_RS14875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ACAV_RS14880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACAV_RS14885	COG1116	anion transmembrane transporter activity
ACAV_RS14890	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ACAV_RS14905	COG2223	nitrite transmembrane transporter activity
ACAV_RS14910	COG0583	DNA-binding transcription factor activity
ACAV_RS14915	COG3971	2-oxopent-4-enoate hydratase activity
ACAV_RS14925	COG0277	FAD linked oxidase domain protein
ACAV_RS14930	COG1012	belongs to the aldehyde dehydrogenase family
ACAV_RS14945	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACAV_RS14950	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ACAV_RS15000	COG0745	RESPONSE REGULATOR receiver
ACAV_RS15015	COG0840	transmembrane signaling receptor activity
ACAV_RS15020	COG2198	Histidine kinase
ACAV_RS15020	COG0643	Histidine kinase
ACAV_RS15025	COG4221	oxidoreductase activity
ACAV_RS15045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACAV_RS15050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACAV_RS15055	COG0517	IMP dehydrogenase activity
ACAV_RS15055	COG0516	GMP reductase activity
ACAV_RS15060	COG0840	transmembrane signaling receptor activity
ACAV_RS15070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACAV_RS15080	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ACAV_RS15085	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACAV_RS15105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACAV_RS15115	COG0243	molybdopterin cofactor binding
ACAV_RS15120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACAV_RS15135	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ACAV_RS15135	COG5297	Belongs to the glycosyl hydrolase family 6
ACAV_RS15145	COG1607	acyl-coa hydrolase
ACAV_RS15150	COG0288	reversible hydration of carbon dioxide
ACAV_RS15165	COG2081	HI0933 family
ACAV_RS15170	COG0640	Transcriptional regulator
ACAV_RS15190	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ACAV_RS15195	COG1610	YqeY-like protein
ACAV_RS15200	COG0625	glutathione transferase activity
ACAV_RS15210	COG0583	DNA-binding transcription factor activity
ACAV_RS15215	COG0473	3-isopropylmalate dehydrogenase activity
ACAV_RS15220	COG1752	Esterase of the alpha-beta hydrolase superfamily
ACAV_RS15225	COG0477	Major facilitator Superfamily
ACAV_RS15265	COG2721	sulfolactate sulfo-lyase activity
ACAV_RS15290	COG0312	modulator of DNA gyrase
ACAV_RS15295	COG3028	Belongs to the UPF0307 family
ACAV_RS15300	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACAV_RS15310	COG1045	serine acetyltransferase
ACAV_RS15320	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ACAV_RS15325	COG4555	ABC transporter
ACAV_RS15340	COG0483	inositol monophosphate 1-phosphatase activity
ACAV_RS15345	COG3437	response regulator, receiver
ACAV_RS15350	COG0784	Response regulator, receiver
ACAV_RS15350	COG5002	protein histidine kinase activity
ACAV_RS15350	COG2205	protein histidine kinase activity
ACAV_RS15360	COG2079	MmgE PrpD family protein
ACAV_RS15370	COG1024	Enoyl-CoA hydratase
ACAV_RS15390	COG5001	Diguanylate cyclase
ACAV_RS15395	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ACAV_RS15400	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ACAV_RS15415	COG3209	COG3209 Rhs family protein
ACAV_RS15445	COG1968	undecaprenyl-diphosphatase activity
ACAV_RS15475	COG3275	phosphorelay sensor kinase activity
ACAV_RS15485	COG1280	lysine exporter protein (LysE YggA)
ACAV_RS15495	COG4133	protoheme IX ABC transporter activity
ACAV_RS15505	COG2005	Transcriptional regulator
ACAV_RS15505	COG3585	molybdate ion transport
ACAV_RS15510	COG3209	COG3209 Rhs family protein
ACAV_RS15525	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ACAV_RS15535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ACAV_RS15540	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ACAV_RS15545	COG0366	Alpha amylase catalytic
ACAV_RS15550	COG0366	Alpha amylase catalytic
ACAV_RS15555	COG0668	transmembrane transport
ACAV_RS15575	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ACAV_RS15580	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACAV_RS15590	COG1722	exodeoxyribonuclease VII activity
ACAV_RS15610	COG1464	Belongs to the NlpA lipoprotein family
ACAV_RS15615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACAV_RS15620	COG2011	ABC-type metal ion transport system permease component
ACAV_RS15660	COG0628	permease
ACAV_RS15665	COG1289	transmembrane transporter activity
ACAV_RS15670	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ACAV_RS15675	COG0181	hydroxymethylbilane synthase activity
ACAV_RS15695	COG0488	(ABC) transporter
ACAV_RS15710	COG0525	valine-tRNA ligase activity
ACAV_RS15715	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ACAV_RS15720	COG0425	Belongs to the sulfur carrier protein TusA family
ACAV_RS15755	COG0583	DNA-binding transcription factor activity
ACAV_RS15760	COG1960	acyl-CoA dehydrogenase activity
ACAV_RS15765	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACAV_RS15800	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ACAV_RS15805	COG0617	tRNA 3'-terminal CCA addition
ACAV_RS15815	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACAV_RS15820	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACAV_RS15845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACAV_RS15870	COG1304	FMN binding
ACAV_RS15885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACAV_RS15920	COG2814	Major facilitator Superfamily
ACAV_RS15935	COG0165	Argininosuccinate lyase
ACAV_RS15940	COG3275	phosphorelay sensor kinase activity
ACAV_RS15955	COG0165	Argininosuccinate lyase
ACAV_RS15965	COG0412	Dienelactone hydrolase
ACAV_RS15995	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ACAV_RS16000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACAV_RS16005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACAV_RS16045	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ACAV_RS16105	COG0210	DNA helicase
ACAV_RS16130	COG0516	GMP reductase activity
ACAV_RS16145	COG1309	transcriptional regulator
ACAV_RS16155	COG2204	response regulator
ACAV_RS16160	COG5002	protein histidine kinase activity
ACAV_RS16165	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ACAV_RS16180	COG2814	Major facilitator Superfamily
ACAV_RS16185	COG3447	MASE1 domain protein
ACAV_RS16185	COG5001	Diguanylate cyclase
ACAV_RS16185	COG5002	protein histidine kinase activity
ACAV_RS16190	COG0513	Belongs to the DEAD box helicase family
ACAV_RS16195	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ACAV_RS16200	COG0501	Belongs to the peptidase M48B family
ACAV_RS16205	COG2154	pterin-4-alpha-carbinolamine dehydratase
ACAV_RS16210	COG1162	GTPase activity
ACAV_RS16215	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ACAV_RS16225	COG0335	large ribosomal subunit rRNA binding
ACAV_RS16230	COG0336	Belongs to the RNA methyltransferase TrmD family
ACAV_RS16235	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ACAV_RS16240	COG0228	four-way junction DNA binding
ACAV_RS16255	COG0306	phosphate transporter
ACAV_RS16260	COG1392	Phosphate transport regulator
ACAV_RS16285	COG0559	Belongs to the binding-protein-dependent transport system permease family
ACAV_RS16290	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ACAV_RS16295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ACAV_RS16300	COG1573	uracil-dna glycosylase
ACAV_RS16310	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ACAV_RS16315	COG1674	ftsk spoiiie
ACAV_RS16320	COG0492	ferredoxin-NADP+ reductase activity
ACAV_RS16325	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ACAV_RS16330	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACAV_RS16335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACAV_RS16350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ACAV_RS16350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACAV_RS16355	COG3866	Pectate lyase
ACAV_RS16385	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ACAV_RS16390	COG3132	Protein of unknown function, DUF480
ACAV_RS16395	COG1960	acyl-CoA dehydrogenase activity
ACAV_RS16415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACAV_RS16420	COG0840	transmembrane signaling receptor activity
ACAV_RS16425	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ACAV_RS16435	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACAV_RS16455	COG0196	riboflavin kinase activity
ACAV_RS16465	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACAV_RS16485	COG4149	molybdate abc transporter
ACAV_RS16490	COG1177	transmembrane transport
ACAV_RS16500	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ACAV_RS16510	COG1283	sodium-dependent phosphate transmembrane transporter activity
ACAV_RS16525	COG0583	DNA-binding transcription factor activity
ACAV_RS16535	COG1064	alcohol dehydrogenase
ACAV_RS16560	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACAV_RS16585	COG2814	Major facilitator Superfamily
ACAV_RS16610	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ACAV_RS16640	COG0697	spore germination
ACAV_RS16725	COG2814	Major facilitator Superfamily
ACAV_RS16770	COG1301	dicarboxylic acid transport
ACAV_RS16775	COG5599	Phosphatase
ACAV_RS16785	COG1522	sequence-specific DNA binding
ACAV_RS16810	COG3181	Tripartite tricarboxylate transporter family receptor
ACAV_RS16840	COG4770	biotin carboxylase activity
ACAV_RS16845	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ACAV_RS16850	COG4336	lyase activity
ACAV_RS16855	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ACAV_RS16860	COG2814	Major facilitator Superfamily
ACAV_RS16890	COG1304	FMN binding
ACAV_RS16895	COG2186	Transcriptional regulator
ACAV_RS16900	COG1620	l-lactate permease
ACAV_RS16920	COG5001	Diguanylate cyclase
ACAV_RS16945	COG0831	urea catabolic process
ACAV_RS16955	COG0832	Belongs to the urease beta subunit family
ACAV_RS16960	COG0804	urea catabolic process
ACAV_RS16965	COG0456	acetyltransferase
ACAV_RS16970	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
ACAV_RS16975	COG0830	nickel cation binding
ACAV_RS16980	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ACAV_RS17005	COG4172	Belongs to the ABC transporter superfamily
ACAV_RS17020	COG0747	negative chemotaxis
ACAV_RS17035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACAV_RS17050	COG2249	NAD(P)H dehydrogenase (quinone) activity
ACAV_RS17060	COG1063	alcohol dehydrogenase
ACAV_RS17070	COG3284	Transcriptional regulator
ACAV_RS17080	COG0840	transmembrane signaling receptor activity
ACAV_RS17110	COG0835	chemotaxis
ACAV_RS17115	COG2199	diguanylate cyclase activity
ACAV_RS17115	COG2200	EAL domain
ACAV_RS17115	COG2202	Pas domain
ACAV_RS17120	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACAV_RS17125	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ACAV_RS17140	COG4968	Prepilin-type N-terminal cleavage methylation domain
ACAV_RS17165	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACAV_RS17165	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACAV_RS17200	COG0784	Response regulator, receiver
ACAV_RS17200	COG4191	Histidine kinase
ACAV_RS17205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACAV_RS17230	COG1595	DNA-templated transcription, initiation
ACAV_RS17245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACAV_RS17250	COG4221	oxidoreductase activity
ACAV_RS17265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACAV_RS17270	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACAV_RS17290	COG1561	YicC-like family, N-terminal region
ACAV_RS17295	COG0194	GDP metabolic process
ACAV_RS17300	COG1758	RNA polymerase activity
ACAV_RS17305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACAV_RS17390	COG2197	response regulator
ACAV_RS17400	COG1420	regulation of RNA biosynthetic process
ACAV_RS17405	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACAV_RS17410	COG0497	DNA recombination
ACAV_RS17415	COG1660	Displays ATPase and GTPase activities
ACAV_RS17430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACAV_RS17445	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACAV_RS17455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACAV_RS17460	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ACAV_RS17465	COG0193	aminoacyl-tRNA hydrolase activity
ACAV_RS17470	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACAV_RS17475	COG0601	transmembrane transport
ACAV_RS17480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACAV_RS17485	COG0444	Belongs to the ABC transporter superfamily
ACAV_RS17490	COG4608	Belongs to the ABC transporter superfamily
ACAV_RS17505	COG0747	negative chemotaxis
ACAV_RS17515	COG3550	peptidyl-serine autophosphorylation
ACAV_RS17540	COG1609	Transcriptional regulator
ACAV_RS17570	COG0302	gtp cyclohydrolase
ACAV_RS17575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACAV_RS17580	COG3568	Endonuclease Exonuclease Phosphatase
ACAV_RS17585	COG0745	RESPONSE REGULATOR receiver
ACAV_RS17605	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACAV_RS17625	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACAV_RS17640	COG2226	methyltransferase
ACAV_RS17665	COG0840	transmembrane signaling receptor activity
ACAV_RS17670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACAV_RS17675	COG1653	transport
ACAV_RS17685	COG0395	ABC-type sugar transport system, permease component
ACAV_RS17690	COG3842	ATPase activity
ACAV_RS17700	COG0584	glycerophosphoryl diester phosphodiesterase
ACAV_RS17705	COG0840	transmembrane signaling receptor activity
ACAV_RS17710	COG3264	Mechanosensitive ion channel
ACAV_RS17710	COG1511	domain protein
ACAV_RS17720	COG0583	DNA-binding transcription factor activity
ACAV_RS17735	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ACAV_RS17740	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACAV_RS17750	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ACAV_RS17755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACAV_RS17760	COG1253	flavin adenine dinucleotide binding
ACAV_RS17770	COG0442	prolyl-tRNA aminoacylation
ACAV_RS17775	COG0494	nUDIX hydrolase
ACAV_RS17780	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ACAV_RS17785	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACAV_RS17790	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ACAV_RS17795	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ACAV_RS17800	COG0142	geranyltranstransferase activity
ACAV_RS17825	COG0237	dephospho-CoA kinase activity
ACAV_RS17830	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
ACAV_RS17835	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ACAV_RS17840	COG0494	nUDIX hydrolase
ACAV_RS17850	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ACAV_RS17855	COG0653	protein targeting
ACAV_RS17860	COG0739	heme binding
ACAV_RS17875	COG2969	positive regulation of protein catabolic process
ACAV_RS17880	COG0625	glutathione transferase activity
ACAV_RS17885	COG2857	Cytochrome c1
ACAV_RS17890	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ACAV_RS17895	COG0723	plastoquinol--plastocyanin reductase activity
ACAV_RS17900	COG1970	mechanosensitive ion channel activity
ACAV_RS17905	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ACAV_RS17910	COG1136	(ABC) transporter
ACAV_RS17915	COG4591	ABC-type transport system involved in lipoprotein release permease component
ACAV_RS17925	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ACAV_RS17930	COG0840	transmembrane signaling receptor activity
ACAV_RS17935	COG0613	PHP domain protein
ACAV_RS17940	COG0009	L-threonylcarbamoyladenylate synthase
ACAV_RS17945	COG0840	transmembrane signaling receptor activity
ACAV_RS17950	COG1994	Peptidase M50
ACAV_RS17955	COG0180	Tryptophanyl-tRNA synthetase
ACAV_RS17960	COG0431	NADPH-dependent FMN reductase
ACAV_RS17965	COG1393	Belongs to the ArsC family
ACAV_RS17970	COG0640	Transcriptional regulator
ACAV_RS17975	COG3209	COG3209 Rhs family protein
ACAV_RS18010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACAV_RS18065	COG4774	siderophore transport
ACAV_RS18100	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
ACAV_RS18115	COG1595	DNA-templated transcription, initiation
ACAV_RS18125	COG4689	acetoacetate decarboxylase
ACAV_RS18130	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS18145	COG0523	cobalamin synthesis protein
ACAV_RS18165	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACAV_RS18170	COG0583	DNA-binding transcription factor activity
ACAV_RS18190	COG0443	Heat shock 70 kDa protein
ACAV_RS18215	COG0038	chloride channel
ACAV_RS18220	COG3209	COG3209 Rhs family protein
ACAV_RS18230	COG0612	Peptidase, M16
ACAV_RS18240	COG0765	amino acid transport
ACAV_RS18245	COG0765	amino acid transport
ACAV_RS18250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACAV_RS18265	COG1137	ATPase activity
ACAV_RS18360	COG0604	alcohol dehydrogenase
ACAV_RS18365	COG1309	transcriptional regulator
ACAV_RS18370	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACAV_RS18375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACAV_RS18380	COG0617	tRNA 3'-terminal CCA addition
ACAV_RS18380	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ACAV_RS18380	COG0517	IMP dehydrogenase activity
ACAV_RS18385	COG1253	flavin adenine dinucleotide binding
ACAV_RS18390	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACAV_RS18395	COG1047	Peptidyl-prolyl cis-trans
ACAV_RS18400	COG2003	Belongs to the UPF0758 family
ACAV_RS18420	COG1193	negative regulation of DNA recombination
ACAV_RS18445	COG0737	Belongs to the 5'-nucleotidase family
ACAV_RS18490	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ACAV_RS18500	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ACAV_RS18505	COG0243	molybdopterin cofactor binding
ACAV_RS18510	COG0840	transmembrane signaling receptor activity
ACAV_RS18515	COG2223	nitrite transmembrane transporter activity
ACAV_RS18520	COG0489	protein tyrosine kinase activity
ACAV_RS18535	COG0028	Belongs to the TPP enzyme family
ACAV_RS18540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACAV_RS18540	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACAV_RS18570	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ACAV_RS18580	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ACAV_RS18585	COG0156	8-amino-7-oxononanoate synthase activity
ACAV_RS18590	COG0602	queuosine metabolic process
ACAV_RS18595	COG0720	synthase
ACAV_RS18620	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ACAV_RS18630	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACAV_RS18635	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ACAV_RS18640	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACAV_RS18645	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ACAV_RS18655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACAV_RS18660	COG0588	phosphoglycerate mutase activity
ACAV_RS18665	COG0793	Belongs to the peptidase S41A family
ACAV_RS18670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ACAV_RS18680	COG2197	response regulator
ACAV_RS18715	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACAV_RS18720	COG0742	ribosomal rna small subunit methyltransferase
ACAV_RS18725	COG0612	Peptidase, M16
ACAV_RS18730	COG0612	Peptidase, M16
ACAV_RS18740	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS18755	COG0840	transmembrane signaling receptor activity
ACAV_RS18760	COG0534	Mate efflux family protein
ACAV_RS18765	COG2095	MarC family integral membrane protein
ACAV_RS18770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACAV_RS18790	COG1999	signal sequence binding
ACAV_RS18795	COG0109	protoheme IX farnesyltransferase activity
ACAV_RS18800	COG1612	heme a metabolic process
ACAV_RS18830	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
ACAV_RS18845	COG2226	methyltransferase
ACAV_RS18850	COG1040	competence protein
ACAV_RS18855	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ACAV_RS18860	COG0583	DNA-binding transcription factor activity
ACAV_RS18875	COG1192	Involved in chromosome partitioning
ACAV_RS18880	COG1280	lysine exporter protein (LysE YggA)
ACAV_RS18890	COG3831	ATPase activity
ACAV_RS18895	COG0714	Associated with various cellular activities
ACAV_RS18900	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ACAV_RS18905	COG3552	Protein containing von Willebrand factor type A (VWA) domain
ACAV_RS18910	COG4715	Zinc finger, swim domain protein
ACAV_RS18915	COG0456	acetyltransferase
ACAV_RS18915	COG0454	-acetyltransferase
ACAV_RS18930	COG1846	Transcriptional regulator
ACAV_RS18935	COG0477	Major facilitator Superfamily
ACAV_RS18940	COG2010	Cytochrome c
ACAV_RS18940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACAV_RS18945	COG2080	2 iron, 2 sulfur cluster binding
ACAV_RS18955	COG3473	Maleate cis-trans isomerase
ACAV_RS18960	COG0596	Alpha beta hydrolase
ACAV_RS18965	COG2309	aminopeptidase activity
ACAV_RS18970	COG1335	isochorismatase
ACAV_RS18975	COG2010	Cytochrome c
ACAV_RS18975	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACAV_RS18995	COG3387	PFAM Glycoside hydrolase 15-related
ACAV_RS19010	COG2031	fatty acid transporter
ACAV_RS19030	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACAV_RS19035	COG0183	Belongs to the thiolase family
ACAV_RS19040	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ACAV_RS19050	COG1414	Transcriptional regulator
ACAV_RS19080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACAV_RS19140	COG0540	Belongs to the ATCase OTCase family
ACAV_RS19160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACAV_RS19175	COG3209	COG3209 Rhs family protein
ACAV_RS19175	COG3209	COG3209 Rhs family protein
ACAV_RS19205	COG1518	maintenance of DNA repeat elements
ACAV_RS19210	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ACAV_RS19230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACAV_RS19260	COG1132	(ABC) transporter
ACAV_RS19265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACAV_RS19265	COG0189	ligase activity
ACAV_RS19270	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACAV_RS19270	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACAV_RS19275	COG3045	CreA protein
ACAV_RS19290	COG3145	DNA-N1-methyladenine dioxygenase activity
ACAV_RS19305	COG0753	catalase activity
ACAV_RS19315	COG2205	protein histidine kinase activity
ACAV_RS19325	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACAV_RS19365	COG0601	transmembrane transport
ACAV_RS19370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACAV_RS19380	COG0514	ATP-dependent DNA helicase (RecQ)
ACAV_RS19395	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACAV_RS19400	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ACAV_RS19405	COG2080	2 iron, 2 sulfur cluster binding
ACAV_RS19440	COG0737	Belongs to the 5'-nucleotidase family
ACAV_RS19445	COG0583	DNA-binding transcription factor activity
ACAV_RS19450	COG2855	membrane
ACAV_RS19455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACAV_RS19465	COG1764	response to oxidative stress
ACAV_RS19470	COG1917	Cupin 2, conserved barrel domain protein
ACAV_RS19470	COG4977	sequence-specific DNA binding
ACAV_RS19480	COG0583	DNA-binding transcription factor activity
ACAV_RS19485	COG0601	transmembrane transport
ACAV_RS19490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACAV_RS19495	COG0444	Belongs to the ABC transporter superfamily
ACAV_RS19500	COG4608	Belongs to the ABC transporter superfamily
ACAV_RS19525	COG0840	transmembrane signaling receptor activity
ACAV_RS19530	COG2267	carboxylic ester hydrolase activity
ACAV_RS19540	COG3002	Belongs to the UPF0753 family
ACAV_RS19545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACAV_RS19550	COG0583	DNA-binding transcription factor activity
ACAV_RS19565	COG1522	sequence-specific DNA binding
ACAV_RS19575	COG2205	protein histidine kinase activity
ACAV_RS19580	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACAV_RS19605	COG0583	DNA-binding transcription factor activity
ACAV_RS19625	COG3845	ABC transporter
ACAV_RS19635	COG1079	Belongs to the binding-protein-dependent transport system permease family
ACAV_RS19645	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACAV_RS19655	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ACAV_RS19660	COG0477	Major facilitator Superfamily
ACAV_RS19665	COG0316	Belongs to the HesB IscA family
ACAV_RS19680	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACAV_RS19685	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACAV_RS19695	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ACAV_RS19700	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACAV_RS19720	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ACAV_RS19730	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ACAV_RS19740	COG2076	Multidrug Resistance protein
ACAV_RS19765	COG1126	abc transporter atp-binding protein
ACAV_RS19770	COG0765	amino acid transport
ACAV_RS19775	COG0765	amino acid transport
ACAV_RS19780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACAV_RS19790	COG0583	DNA-binding transcription factor activity
ACAV_RS19795	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ACAV_RS19800	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ACAV_RS19800	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ACAV_RS19805	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACAV_RS19810	COG5265	(ABC) transporter
ACAV_RS19825	COG3181	Tripartite tricarboxylate transporter family receptor
ACAV_RS19830	COG1024	Enoyl-CoA hydratase
ACAV_RS19840	COG0183	Belongs to the thiolase family
ACAV_RS19850	COG1024	Enoyl-CoA hydratase
ACAV_RS19850	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACAV_RS19860	COG1960	acyl-CoA dehydrogenase activity
ACAV_RS19870	COG1309	transcriptional regulator
ACAV_RS19880	COG0745	RESPONSE REGULATOR receiver
ACAV_RS19885	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACAV_RS19925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACAV_RS19940	COG1450	Type ii and iii secretion system protein
ACAV_RS19970	COG2165	general secretion pathway protein
ACAV_RS19980	COG2165	general secretion pathway protein
ACAV_RS19985	COG1459	type II secretion system
ACAV_RS19990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACAV_RS20030	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ACAV_RS20035	COG1652	LysM domain
ACAV_RS20060	COG0204	Acyl-transferase
ACAV_RS20065	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ACAV_RS20075	COG0751	glycine-tRNA ligase activity
ACAV_RS20080	COG0752	glycyl-tRNA synthetase alpha subunit
ACAV_RS20085	COG3258	Cytochrome c
ACAV_RS20095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACAV_RS20110	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ACAV_RS20115	COG4535	Mg2 and Co2 transporter CorC
ACAV_RS20120	COG3209	COG3209 Rhs family protein
ACAV_RS20130	COG1522	sequence-specific DNA binding
ACAV_RS20135	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ACAV_RS20155	COG3186	Phenylalanine-4-hydroxylase
ACAV_RS20170	COG0318	PFAM AMP-dependent synthetase and ligase
ACAV_RS20180	COG1129	ABC transporter
ACAV_RS20185	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACAV_RS20195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACAV_RS20200	COG1869	D-ribose catabolic process
ACAV_RS20215	COG0739	heme binding
ACAV_RS20215	COG0741	lytic transglycosylase activity
ACAV_RS20215	COG1196	nuclear chromosome segregation
ACAV_RS20220	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ACAV_RS20230	COG0625	glutathione transferase activity
ACAV_RS20240	COG0617	tRNA 3'-terminal CCA addition
ACAV_RS20255	COG3387	PFAM Glycoside hydrolase 15-related
ACAV_RS20260	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ACAV_RS20295	COG0456	acetyltransferase
ACAV_RS20310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACAV_RS20320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACAV_RS20325	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ACAV_RS20335	COG2175	clavaminate synthase activity
ACAV_RS20360	COG3842	ATPase activity
ACAV_RS20370	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS20380	COG2879	small protein
ACAV_RS20385	COG1966	Carbon starvation protein
ACAV_RS20400	COG0037	tRNA processing
ACAV_RS20410	COG0406	alpha-ribazole phosphatase activity
ACAV_RS20415	COG3616	Alanine racemase, N-terminal domain
ACAV_RS20435	COG2255	four-way junction helicase activity
ACAV_RS20450	COG0632	four-way junction helicase activity
ACAV_RS20455	COG1702	phosphate starvation-inducible protein PhoH
ACAV_RS20475	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACAV_RS20480	COG1490	D-aminoacyl-tRNA deacylase activity
ACAV_RS20485	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ACAV_RS20500	COG2188	Transcriptional regulator
ACAV_RS20505	COG0513	Belongs to the DEAD box helicase family
ACAV_RS20510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ACAV_RS20515	COG3706	GGDEF domain
ACAV_RS20525	COG2814	Major facilitator Superfamily
ACAV_RS20535	COG3485	protocatechuate 3,4-dioxygenase
ACAV_RS20580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACAV_RS20585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ACAV_RS20585	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ACAV_RS20595	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACAV_RS20595	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACAV_RS20615	COG0443	Heat shock 70 kDa protein
ACAV_RS20625	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ACAV_RS20640	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ACAV_RS20645	COG0583	DNA-binding transcription factor activity
ACAV_RS20650	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACAV_RS20660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACAV_RS20680	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACAV_RS20685	COG3971	2-oxopent-4-enoate hydratase activity
ACAV_RS20695	COG1846	Transcriptional regulator
ACAV_RS20700	COG1764	response to oxidative stress
ACAV_RS20710	COG0515	serine threonine protein kinase
ACAV_RS20710	COG2815	serine threonine protein kinase
ACAV_RS20715	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ACAV_RS20720	COG0745	RESPONSE REGULATOR receiver
ACAV_RS20750	COG3209	COG3209 Rhs family protein
ACAV_RS20765	COG0326	Molecular chaperone. Has ATPase activity
ACAV_RS20775	COG1187	pseudouridine synthase activity
ACAV_RS20790	COG0840	transmembrane signaling receptor activity
ACAV_RS20800	COG3250	beta-galactosidase activity
ACAV_RS20810	COG3568	Endonuclease Exonuclease Phosphatase
ACAV_RS20815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACAV_RS20820	COG0392	lysyltransferase activity
ACAV_RS20825	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
ACAV_RS20860	COG3181	Tripartite tricarboxylate transporter family receptor
ACAV_RS20870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACAV_RS20875	COG1024	Enoyl-CoA hydratase
ACAV_RS20880	COG1960	acyl-CoA dehydrogenase activity
ACAV_RS20885	COG1960	acyl-CoA dehydrogenase activity
ACAV_RS20890	COG1024	Enoyl-CoA hydratase
ACAV_RS20890	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACAV_RS20895	COG0583	DNA-binding transcription factor activity
ACAV_RS20900	COG1280	lysine exporter protein (LysE YggA)
ACAV_RS20905	COG1522	sequence-specific DNA binding
ACAV_RS20910	COG0501	Belongs to the peptidase M48B family
ACAV_RS20925	COG0418	dihydroorotase activity
ACAV_RS20930	COG2205	protein histidine kinase activity
ACAV_RS20935	COG0745	RESPONSE REGULATOR receiver
ACAV_RS20950	COG0577	efflux transmembrane transporter activity
ACAV_RS20950	COG1136	(ABC) transporter
ACAV_RS20980	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACAV_RS21015	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACAV_RS21030	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ACAV_RS21060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACAV_RS21075	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ACAV_RS21080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACAV_RS21085	COG0318	PFAM AMP-dependent synthetase and ligase
ACAV_RS21100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACAV_RS21110	COG3012	SEC-C Motif Domain Protein
ACAV_RS21120	COG1960	acyl-CoA dehydrogenase activity
ACAV_RS21135	COG0183	Belongs to the thiolase family
ACAV_RS21140	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
ACAV_RS21145	COG0288	reversible hydration of carbon dioxide
ACAV_RS21150	COG1960	acyl-CoA dehydrogenase activity
ACAV_RS21155	COG0789	Transcriptional regulator
ACAV_RS21185	COG0488	(ABC) transporter
ACAV_RS21190	COG2201	protein-glutamate methylesterase activity
ACAV_RS21195	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ACAV_RS21200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACAV_RS21205	COG0835	chemotaxis
ACAV_RS21210	COG0643	Histidine kinase
ACAV_RS21210	COG2198	Histidine kinase
ACAV_RS21215	COG0745	RESPONSE REGULATOR receiver
ACAV_RS21230	COG2197	response regulator
ACAV_RS21255	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACAV_RS21265	COG1580	Controls the rotational direction of flagella during chemotaxis
ACAV_RS21295	COG1766	The M ring may be actively involved in energy transduction
ACAV_RS21300	COG1677	Flagellar hook-basal body complex protein FliE
ACAV_RS21340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACAV_RS21345	COG1216	Glycosyl transferase, family 2
ACAV_RS21345	COG0438	transferase activity, transferring glycosyl groups
ACAV_RS21350	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ACAV_RS21355	COG1360	Flagellar Motor Protein
ACAV_RS21360	COG0745	RESPONSE REGULATOR receiver
ACAV_RS21365	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ACAV_RS21410	COG1815	bacterial-type flagellum-dependent cell motility
ACAV_RS21415	COG1558	bacterial-type flagellum-dependent cell motility
ACAV_RS21420	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ACAV_RS21430	COG4787	bacterial-type flagellum-dependent cell motility
ACAV_RS21440	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ACAV_RS21445	COG1706	bacterial-type flagellum-dependent cell motility
ACAV_RS21450	COG1705	Flagellar rod assembly protein muramidase FlgJ
ACAV_RS21450	COG3951	Flagellar rod assembly protein muramidase FlgJ
ACAV_RS21460	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ACAV_RS21470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACAV_RS21480	COG0697	spore germination
ACAV_RS21485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACAV_RS21490	COG0625	glutathione transferase activity
ACAV_RS21495	COG0384	phenazine biosynthesis protein PhzF
ACAV_RS21525	COG0840	transmembrane signaling receptor activity
ACAV_RS21605	COG0861	Integral membrane protein TerC family
ACAV_RS21610	COG0583	DNA-binding transcription factor activity
ACAV_RS21645	COG3119	arylsulfatase activity
ACAV_RS21660	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACAV_RS21665	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ACAV_RS21685	COG0210	DNA helicase
ACAV_RS21705	COG0343	queuine tRNA-ribosyltransferase activity
ACAV_RS21715	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS21760	COG1522	sequence-specific DNA binding
ACAV_RS21765	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ACAV_RS21770	COG3181	Tripartite tricarboxylate transporter family receptor
ACAV_RS21775	COG0840	transmembrane signaling receptor activity
ACAV_RS21865	COG3181	Tripartite tricarboxylate transporter family receptor
ACAV_RS21870	COG2072	flavoprotein involved in K transport
ACAV_RS21880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACAV_RS21900	COG2365	Tyrosine phosphatase family
ACAV_RS21910	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS21920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACAV_RS21925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ACAV_RS21925	COG1116	anion transmembrane transporter activity
ACAV_RS21940	COG3046	protein related to deoxyribodipyrimidine photolyase
ACAV_RS21950	COG3550	peptidyl-serine autophosphorylation
ACAV_RS21960	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ACAV_RS21985	COG0270	DNA (cytosine-5-)-methyltransferase activity
ACAV_RS22005	COG2032	superoxide dismutase activity
ACAV_RS22010	COG0243	molybdopterin cofactor binding
ACAV_RS22025	COG3550	peptidyl-serine autophosphorylation
ACAV_RS22040	COG2204	response regulator
ACAV_RS22045	COG5000	phosphorelay sensor kinase activity
ACAV_RS22055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACAV_RS22055	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ACAV_RS22065	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACAV_RS22070	COG0085	RNA polymerase activity
ACAV_RS22075	COG0222	ribosome binding
ACAV_RS22080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACAV_RS22085	COG0081	regulation of translation
ACAV_RS22090	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACAV_RS22100	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACAV_RS22110	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACAV_RS22155	COG0189	ligase activity
ACAV_RS22160	COG3135	benzoate transporter
ACAV_RS22165	COG3158	transport of potassium into the cell
ACAV_RS22175	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ACAV_RS22180	COG0569	domain protein
ACAV_RS22185	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ACAV_RS22215	COG0495	leucyl-tRNA aminoacylation
ACAV_RS22225	COG5001	Diguanylate cyclase
ACAV_RS22225	COG3300	MHYT domain
ACAV_RS22240	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ACAV_RS22245	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACAV_RS22250	COG0735	belongs to the Fur family
ACAV_RS22255	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ACAV_RS22265	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ACAV_RS22270	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ACAV_RS22280	COG3118	belongs to the thioredoxin family
ACAV_RS22285	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACAV_RS22290	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ACAV_RS22295	COG0009	L-threonylcarbamoyladenylate synthase
ACAV_RS22320	COG1214	PFAM Peptidase M22, glycoprotease
ACAV_RS22335	COG0598	Magnesium transport protein CorA
ACAV_RS22345	COG0318	PFAM AMP-dependent synthetase and ligase
ACAV_RS22380	COG0469	pyruvate kinase activity
ACAV_RS22400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACAV_RS22410	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
ACAV_RS22415	COG0006	proline dipeptidase activity
ACAV_RS22435	COG2268	Band 7 protein
ACAV_RS22440	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACAV_RS22445	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ACAV_RS22450	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ACAV_RS22465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACAV_RS22475	COG0583	DNA-binding transcription factor activity
ACAV_RS22510	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ACAV_RS22565	COG0668	transmembrane transport
ACAV_RS22575	COG2194	sulfuric ester hydrolase activity
ACAV_RS22580	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS22625	COG1714	RDD family
ACAV_RS22650	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ACAV_RS22650	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ACAV_RS22680	COG0583	DNA-binding transcription factor activity
ACAV_RS22690	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ACAV_RS22705	COG0642	Histidine kinase
ACAV_RS22720	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACAV_RS22725	COG2137	regulation of response to DNA damage stimulus
ACAV_RS22735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACAV_RS22740	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACAV_RS22745	COG1862	Preprotein translocase
ACAV_RS22760	COG1522	sequence-specific DNA binding
ACAV_RS22770	COG2814	Major facilitator Superfamily
ACAV_RS22785	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ACAV_RS22815	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ACAV_RS22820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACAV_RS22835	COG1309	transcriptional regulator
ACAV_RS22845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACAV_RS22870	COG0625	glutathione transferase activity
ACAV_RS22895	COG0861	Integral membrane protein TerC family
ACAV_RS22905	COG1950	PFAM Membrane protein of
ACAV_RS22910	COG4783	chaperone-mediated protein folding
ACAV_RS22915	COG0315	cyclic pyranopterin monophosphate synthase activity
ACAV_RS22940	COG1716	ATPase activity
ACAV_RS22945	COG0631	protein serine/threonine phosphatase activity
ACAV_RS22950	COG0861	Integral membrane protein TerC family
ACAV_RS22955	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ACAV_RS22960	COG0045	succinate-CoA ligase (ADP-forming) activity
ACAV_RS22965	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACAV_RS22970	COG0758	DNA mediated transformation
ACAV_RS22980	COG0242	peptide deformylase activity
ACAV_RS22990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACAV_RS23005	COG0126	phosphoglycerate kinase activity
ACAV_RS23010	COG0284	orotidine-5'-phosphate decarboxylase activity
ACAV_RS23040	COG0840	transmembrane signaling receptor activity
ACAV_RS23070	COG4948	Mandelate Racemase Muconate Lactonizing
ACAV_RS23080	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACAV_RS23085	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ACAV_RS23090	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ACAV_RS23100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACAV_RS23115	COG1609	Transcriptional regulator
ACAV_RS23125	COG3842	ATPase activity
ACAV_RS23135	COG1175	transmembrane transport
ACAV_RS23140	COG0395	ABC-type sugar transport system, permease component
ACAV_RS23145	COG3386	PFAM SMP-30 Gluconolaconase
ACAV_RS23165	COG0529	Catalyzes the synthesis of activated sulfate
ACAV_RS23175	COG2814	Major facilitator Superfamily
ACAV_RS23185	COG0629	single-stranded DNA binding
ACAV_RS23190	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ACAV_RS23215	COG0732	type I restriction modification DNA specificity domain
ACAV_RS23220	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ACAV_RS23245	COG2200	EAL domain
ACAV_RS23285	COG0640	Transcriptional regulator
ACAV_RS23305	COG1028	Short-chain dehydrogenase reductase Sdr
ACAV_RS23315	COG0318	PFAM AMP-dependent synthetase and ligase
ACAV_RS23330	COG1620	l-lactate permease
ACAV_RS23350	COG0482	sulfurtransferase activity
ACAV_RS23365	COG0583	DNA-binding transcription factor activity
ACAV_RS23385	COG0307	riboflavin synthase, alpha
ACAV_RS23405	COG2375	cellular response to nickel ion
ACAV_RS23410	COG1695	Transcriptional regulator
ACAV_RS23420	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ACAV_RS23510	COG1802	Transcriptional regulator
ACAV_RS23560	COG0281	malic enzyme
ACAV_RS23560	COG0280	phosphate acetyltransferase
ACAV_RS23570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACAV_RS23575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACAV_RS23580	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ACAV_RS23590	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ACAV_RS23605	COG1196	nuclear chromosome segregation
ACAV_RS23615	COG3706	GGDEF domain
ACAV_RS23620	COG2814	Major facilitator Superfamily
ACAV_RS23635	COG2207	Transcriptional regulator
ACAV_RS23640	COG0531	amino acid
ACAV_RS23645	COG4303	Ethanolamine ammonia lyase large subunit
ACAV_RS23650	COG4302	ethanolamine ammonia-lyase activity
ACAV_RS23665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACAV_RS23670	COG2119	membrane
ACAV_RS23675	COG0724	RNA recognition motif
ACAV_RS23680	COG0724	RNA recognition motif
ACAV_RS23685	COG0300	oxidoreductase activity
ACAV_RS23695	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ACAV_RS23710	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACAV_RS23730	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ACAV_RS23740	COG0706	membrane insertase activity
ACAV_RS23745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ACAV_RS23750	COG0594	ribonuclease P activity
ACAV_RS23755	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ACAV_RS23785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACAV_RS23835	COG0477	Major facilitator Superfamily
ACAV_RS23880	COG0076	glutamate decarboxylase activity
ACAV_RS23890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released