locus-tag	class	description
AAVE_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AAVE_RS00030	COG4650	regulator
AAVE_RS00045	COG1764	response to oxidative stress
AAVE_RS00065	COG1199	ATP-dependent helicase activity
AAVE_RS00080	COG2176	DNA-directed DNA polymerase activity
AAVE_RS00095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AAVE_RS00100	COG0791	NLP P60 protein
AAVE_RS00105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AAVE_RS00125	COG2974	May be involved in recombination
AAVE_RS00130	COG2715	membrane protein required for spore maturation
AAVE_RS00155	COG0183	Belongs to the thiolase family
AAVE_RS00160	COG0789	Transcriptional regulator
AAVE_RS00170	COG2217	Heavy metal translocating P-type atpase
AAVE_RS00195	COG0745	RESPONSE REGULATOR receiver
AAVE_RS00200	COG0642	Histidine kinase
AAVE_RS00220	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AAVE_RS00225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AAVE_RS00245	COG0445	tRNA wobble uridine modification
AAVE_RS00250	COG0357	Ribosomal RNA small subunit methyltransferase G
AAVE_RS00255	COG1280	lysine exporter protein (LysE YggA)
AAVE_RS00260	COG1192	Involved in chromosome partitioning
AAVE_RS00285	COG0493	'glutamate synthase
AAVE_RS00305	COG0277	FAD linked oxidase domain protein
AAVE_RS00310	COG0546	phosphoglycolate phosphatase activity
AAVE_RS00310	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AAVE_RS00325	COG2272	Belongs to the type-B carboxylesterase lipase family
AAVE_RS00345	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AAVE_RS00380	COG3411	Ferredoxin
AAVE_RS00395	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AAVE_RS00470	COG0277	FAD linked oxidase domain protein
AAVE_RS00485	COG2096	Adenosyltransferase
AAVE_RS00490	COG2050	protein possibly involved in aromatic compounds catabolism
AAVE_RS00505	COG2233	PERMEase
AAVE_RS00525	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AAVE_RS00535	COG0583	DNA-binding transcription factor activity
AAVE_RS00550	COG1116	anion transmembrane transporter activity
AAVE_RS00555	COG0395	ABC-type sugar transport system, permease component
AAVE_RS00575	COG1414	Transcriptional regulator
AAVE_RS00580	COG0501	Belongs to the peptidase M48B family
AAVE_RS00590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AAVE_RS00600	COG2423	ornithine cyclodeaminase activity
AAVE_RS00610	COG1183	phosphatidylcholine synthase activity
AAVE_RS00615	COG0850	regulation of cytokinetic process
AAVE_RS00620	COG2894	cell division
AAVE_RS00625	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AAVE_RS00630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AAVE_RS00645	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AAVE_RS00650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AAVE_RS00660	COG1309	transcriptional regulator
AAVE_RS00685	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AAVE_RS00690	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AAVE_RS00695	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AAVE_RS00700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AAVE_RS00710	COG1960	acyl-CoA dehydrogenase activity
AAVE_RS00730	COG0625	glutathione transferase activity
AAVE_RS00735	COG2271	Major facilitator Superfamily
AAVE_RS00745	COG2423	ornithine cyclodeaminase activity
AAVE_RS00775	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AAVE_RS00830	COG0840	transmembrane signaling receptor activity
AAVE_RS00865	COG0583	DNA-binding transcription factor activity
AAVE_RS00880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AAVE_RS00890	COG3181	Tripartite tricarboxylate transporter family receptor
AAVE_RS00930	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AAVE_RS00940	COG2326	polyphosphate kinase activity
AAVE_RS00980	COG0583	DNA-binding transcription factor activity
AAVE_RS01010	COG0583	DNA-binding transcription factor activity
AAVE_RS01025	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AAVE_RS01030	COG1126	abc transporter atp-binding protein
AAVE_RS01035	COG0765	amino acid transport
AAVE_RS01040	COG0765	amino acid transport
AAVE_RS01060	COG1410	methionine synthase
AAVE_RS01060	COG0646	methionine synthase
AAVE_RS01100	COG0583	DNA-binding transcription factor activity
AAVE_RS01110	COG0840	transmembrane signaling receptor activity
AAVE_RS01115	COG3181	Tripartite tricarboxylate transporter family receptor
AAVE_RS01120	COG4191	Histidine kinase
AAVE_RS01130	COG0606	chelatase, subunit chli
AAVE_RS01140	COG0347	Belongs to the P(II) protein family
AAVE_RS01145	COG0004	ammonium transporteR
AAVE_RS01180	COG0277	FAD linked oxidase domain protein
AAVE_RS01190	COG0247	lactate metabolic process
AAVE_RS01220	COG0386	Belongs to the glutathione peroxidase family
AAVE_RS01230	COG0477	Major facilitator Superfamily
AAVE_RS01235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AAVE_RS01245	COG0747	negative chemotaxis
AAVE_RS01265	COG0625	glutathione transferase activity
AAVE_RS01270	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AAVE_RS01315	COG1215	transferase activity, transferring glycosyl groups
AAVE_RS01335	COG0477	Major facilitator Superfamily
AAVE_RS01345	COG0745	RESPONSE REGULATOR receiver
AAVE_RS01350	COG2211	Major facilitator Superfamily
AAVE_RS01370	COG0501	Belongs to the peptidase M48B family
AAVE_RS01375	COG0471	metal ion transport
AAVE_RS01380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AAVE_RS01400	COG0583	DNA-binding transcription factor activity
AAVE_RS01405	COG2814	Major facilitator Superfamily
AAVE_RS01415	COG0708	Exodeoxyribonuclease III
AAVE_RS01420	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AAVE_RS01430	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AAVE_RS01435	COG0154	amidase activity
AAVE_RS01440	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AAVE_RS01445	COG1077	Cell shape determining protein MreB Mrl
AAVE_RS01455	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AAVE_RS01460	COG0768	penicillin binding
AAVE_RS01475	COG0765	amino acid transport
AAVE_RS01480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AAVE_RS01485	COG1760	l-serine dehydratase
AAVE_RS01505	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AAVE_RS01510	COG1127	ABC transporter
AAVE_RS01535	COG3237	CsbD-like
AAVE_RS01555	COG4452	Inner membrane protein CreD
AAVE_RS01560	COG2205	protein histidine kinase activity
AAVE_RS01565	COG0745	RESPONSE REGULATOR receiver
AAVE_RS01570	COG2095	MarC family integral membrane protein
AAVE_RS01575	COG1028	Short-chain dehydrogenase reductase Sdr
AAVE_RS01580	COG0412	Dienelactone hydrolase
AAVE_RS01595	COG1846	Transcriptional regulator
AAVE_RS01600	COG0519	Catalyzes the synthesis of GMP from XMP
AAVE_RS01600	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AAVE_RS01605	COG0598	Magnesium transport protein CorA
AAVE_RS01615	COG1981	membrane
AAVE_RS01630	COG2945	thiolester hydrolase activity
AAVE_RS01635	COG1686	Belongs to the peptidase S11 family
AAVE_RS01640	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AAVE_RS01645	COG0049	tRNA binding
AAVE_RS01650	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AAVE_RS01655	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AAVE_RS01660	COG0051	transcription antitermination factor activity, RNA binding
AAVE_RS01665	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AAVE_RS01670	COG0088	Forms part of the polypeptide exit tunnel
AAVE_RS01675	COG0089	rRNA binding
AAVE_RS01680	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AAVE_RS01685	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AAVE_RS01690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AAVE_RS01695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AAVE_RS01700	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AAVE_RS01705	COG0255	Belongs to the universal ribosomal protein uL29 family
AAVE_RS01710	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AAVE_RS01715	COG0678	peroxiredoxin activity
AAVE_RS01725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AAVE_RS01740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AAVE_RS01745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AAVE_RS01755	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AAVE_RS01760	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AAVE_RS01765	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AAVE_RS01770	COG2205	protein histidine kinase activity
AAVE_RS01775	COG0745	RESPONSE REGULATOR receiver
AAVE_RS01790	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AAVE_RS01795	COG0321	lipoyl(octanoyl) transferase activity
AAVE_RS01800	COG2921	Belongs to the UPF0250 family
AAVE_RS01810	COG0356	it plays a direct role in the translocation of protons across the membrane
AAVE_RS01820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AAVE_RS01825	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AAVE_RS01830	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AAVE_RS01835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AAVE_RS01840	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AAVE_RS01845	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AAVE_RS01850	COG1793	dna ligase
AAVE_RS01850	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AAVE_RS01855	COG1793	dna ligase
AAVE_RS01860	COG1201	RNA secondary structure unwinding
AAVE_RS01920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AAVE_RS01925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AAVE_RS01985	COG0121	glutamine amidotransferase
AAVE_RS01990	COG2814	Major facilitator Superfamily
AAVE_RS01995	COG1942	4-Oxalocrotonate Tautomerase
AAVE_RS02005	COG0840	transmembrane signaling receptor activity
AAVE_RS02010	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AAVE_RS02040	COG0018	arginyl-trna synthetase
AAVE_RS02050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AAVE_RS02060	COG1137	ATPase activity
AAVE_RS02065	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AAVE_RS02070	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AAVE_RS02090	COG4178	(ABC) transporter
AAVE_RS02100	COG0653	protein targeting
AAVE_RS02105	COG0659	secondary active sulfate transmembrane transporter activity
AAVE_RS02120	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AAVE_RS02140	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AAVE_RS02155	COG2967	ApaG domain
AAVE_RS02160	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AAVE_RS02170	COG0546	phosphoglycolate phosphatase activity
AAVE_RS02190	COG2207	Transcriptional regulator
AAVE_RS02210	COG4794	Type iii secretion
AAVE_RS02215	COG4790	Type iii secretion
AAVE_RS02235	COG4789	Type iii secretion
AAVE_RS02240	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AAVE_RS02355	COG0500	methyltransferase
AAVE_RS02360	COG0741	lytic transglycosylase activity
AAVE_RS02360	COG0739	heme binding
AAVE_RS02360	COG1196	nuclear chromosome segregation
AAVE_RS02400	COG0582	viral genome integration into host DNA
AAVE_RS02440	COG2003	Belongs to the UPF0758 family
AAVE_RS02455	COG2084	Dehydrogenase
AAVE_RS02475	COG3209	COG3209 Rhs family protein
AAVE_RS02570	COG0587	DNA-directed DNA polymerase activity
AAVE_RS02585	COG0587	DNA-directed DNA polymerase activity
AAVE_RS02750	COG0270	DNA (cytosine-5-)-methyltransferase activity
AAVE_RS02755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AAVE_RS02800	COG2894	cell division
AAVE_RS02820	COG0697	spore germination
AAVE_RS02850	COG0251	oxidation-reduction process
AAVE_RS02870	COG2336	PFAM SpoVT AbrB
AAVE_RS02890	COG0512	Glutamine amidotransferase of anthranilate synthase
AAVE_RS02895	COG1280	lysine exporter protein (LysE YggA)
AAVE_RS02900	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AAVE_RS02905	COG0134	indole-3-glycerol-phosphate synthase activity
AAVE_RS02910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AAVE_RS02945	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AAVE_RS02955	COG0783	Belongs to the Dps family
AAVE_RS02960	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AAVE_RS02975	COG0463	Glycosyl transferase, family 2
AAVE_RS02990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AAVE_RS03000	COG3842	ATPase activity
AAVE_RS03005	COG3842	ATPase activity
AAVE_RS03015	COG0395	ABC-type sugar transport system, permease component
AAVE_RS03035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AAVE_RS03040	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AAVE_RS03045	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AAVE_RS03050	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AAVE_RS03055	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AAVE_RS03060	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AAVE_RS03065	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AAVE_RS03070	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AAVE_RS03075	COG1841	ribosomal large subunit assembly
AAVE_RS03080	COG0200	Binds to the 23S rRNA
AAVE_RS03085	COG0201	protein transport
AAVE_RS03090	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AAVE_RS03095	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AAVE_RS03100	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AAVE_RS03105	COG0202	RNA polymerase activity
AAVE_RS03110	COG0203	ribosomal protein L17
AAVE_RS03120	COG0443	Heat shock 70 kDa protein
AAVE_RS03125	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AAVE_RS03130	COG0792	nuclease activity
AAVE_RS03135	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AAVE_RS03140	COG2823	Periplasmic or secreted lipoprotein
AAVE_RS03145	COG2084	Dehydrogenase
AAVE_RS03160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AAVE_RS03185	COG2733	membrane
AAVE_RS03205	COG0277	FAD linked oxidase domain protein
AAVE_RS03215	COG0583	DNA-binding transcription factor activity
AAVE_RS03235	COG1285	pathogenesis
AAVE_RS03245	COG3850	Histidine kinase
AAVE_RS03250	COG2197	response regulator
AAVE_RS03265	COG4771	TonB-dependent receptor
AAVE_RS03280	COG2223	nitrite transmembrane transporter activity
AAVE_RS03285	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AAVE_RS03290	COG1140	nitrate reductase beta subunit
AAVE_RS03295	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AAVE_RS03300	COG2181	nitrate reductase activity
AAVE_RS03305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AAVE_RS03310	COG0288	reversible hydration of carbon dioxide
AAVE_RS03325	COG3945	hemerythrin HHE cation binding domain
AAVE_RS03335	COG4804	nuclease activity
AAVE_RS03350	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AAVE_RS03370	COG1475	DNA binding
AAVE_RS03375	COG5489	Protein of unknown function (DUF736)
AAVE_RS03420	COG4959	Type IV secretory pathway protease TraF
AAVE_RS03455	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AAVE_RS03475	COG0738	Major facilitator superfamily
AAVE_RS03500	COG4372	Transposase
AAVE_RS03515	COG2249	NAD(P)H dehydrogenase (quinone) activity
AAVE_RS03525	COG0656	L-ascorbic acid biosynthetic process
AAVE_RS03530	COG0583	DNA-binding transcription factor activity
AAVE_RS03580	COG4962	Type ii secretion system protein e
AAVE_RS03585	COG3838	Conjugal transfer protein Trbc
AAVE_RS03595	COG3451	type IV secretory pathway VirB4
AAVE_RS03610	COG3846	protein secretion by the type IV secretion system
AAVE_RS03640	COG0477	Major facilitator Superfamily
AAVE_RS03685	COG1272	protein, Hemolysin III
AAVE_RS03695	COG3706	GGDEF domain
AAVE_RS03705	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AAVE_RS03710	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AAVE_RS03720	COG0129	dihydroxy-acid dehydratase activity
AAVE_RS03725	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AAVE_RS03735	COG0583	DNA-binding transcription factor activity
AAVE_RS03740	COG1741	Belongs to the pirin family
AAVE_RS03745	COG1335	isochorismatase
AAVE_RS03785	COG0243	molybdopterin cofactor binding
AAVE_RS03800	COG1473	amidohydrolase
AAVE_RS03825	COG0519	Catalyzes the synthesis of GMP from XMP
AAVE_RS03830	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AAVE_RS03885	COG3267	Type II secretory pathway component ExeA
AAVE_RS03885	COG3409	Peptidoglycan-binding domain 1 protein
AAVE_RS03890	COG3266	domain, Protein
AAVE_RS03900	COG4269	membrane
AAVE_RS03935	COG0625	glutathione transferase activity
AAVE_RS03940	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AAVE_RS03950	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AAVE_RS03955	COG1649	PFAM Uncharacterised BCR, COG1649
AAVE_RS03975	COG3447	MASE1 domain protein
AAVE_RS03975	COG5001	Diguanylate cyclase
AAVE_RS03975	COG5002	protein histidine kinase activity
AAVE_RS03980	COG0523	cobalamin synthesis protein
AAVE_RS03995	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AAVE_RS04000	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AAVE_RS04005	COG2001	Belongs to the MraZ family
AAVE_RS04010	COG0275	rRNA processing
AAVE_RS04015	COG3116	cell division
AAVE_RS04025	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AAVE_RS04030	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AAVE_RS04035	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AAVE_RS04040	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AAVE_RS04045	COG0772	Belongs to the SEDS family
AAVE_RS04050	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AAVE_RS04055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AAVE_RS04060	COG1181	Belongs to the D-alanine--D-alanine ligase family
AAVE_RS04065	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AAVE_RS04075	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AAVE_RS04080	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AAVE_RS04085	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AAVE_RS04090	COG0840	transmembrane signaling receptor activity
AAVE_RS04105	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AAVE_RS04110	COG0575	Belongs to the CDS family
AAVE_RS04135	COG1414	Transcriptional regulator
AAVE_RS04140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AAVE_RS04145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AAVE_RS04155	COG0557	exoribonuclease II activity
AAVE_RS04165	COG3150	esterase
AAVE_RS04170	COG0772	Belongs to the SEDS family
AAVE_RS04180	COG0154	amidase activity
AAVE_RS04185	COG0312	modulator of DNA gyrase
AAVE_RS04195	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AAVE_RS04205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AAVE_RS04215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AAVE_RS04220	COG0511	ligase activity, forming carbon-carbon bonds
AAVE_RS04225	COG0439	Biotin carboxylase
AAVE_RS04230	COG2264	protein methyltransferase activity
AAVE_RS04240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AAVE_RS04250	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AAVE_RS04285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AAVE_RS04295	COG2204	response regulator
AAVE_RS04305	COG2205	protein histidine kinase activity
AAVE_RS04310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AAVE_RS04335	COG0431	NADPH-dependent FMN reductase
AAVE_RS04340	COG3829	transcription factor binding
AAVE_RS04345	COG1024	Enoyl-CoA hydratase
AAVE_RS04360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AAVE_RS04365	COG0633	Ferredoxin
AAVE_RS04365	COG3217	Mosc domain protein beta barrel domain protein
AAVE_RS04370	COG0012	GTP binding
AAVE_RS04375	COG1125	glycine betaine transport
AAVE_RS04375	COG0517	IMP dehydrogenase activity
AAVE_RS04385	COG1238	metal cluster binding
AAVE_RS04395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AAVE_RS04400	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AAVE_RS04405	COG0138	bifunctional purine biosynthesis protein purh
AAVE_RS04415	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AAVE_RS04420	COG0351	phosphomethylpyrimidine kinase
AAVE_RS04420	COG0352	thiamine-phosphate diphosphorylase activity
AAVE_RS04420	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AAVE_RS04435	COG0835	chemotaxis
AAVE_RS04440	COG0840	transmembrane signaling receptor activity
AAVE_RS04445	COG0643	Histidine kinase
AAVE_RS04445	COG2198	Histidine kinase
AAVE_RS04450	COG0415	Belongs to the DNA photolyase family
AAVE_RS04455	COG1678	Uncharacterized ACR, COG1678
AAVE_RS04460	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AAVE_RS04465	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AAVE_RS04470	COG0540	Belongs to the ATCase OTCase family
AAVE_RS04485	COG3842	ATPase activity
AAVE_RS04490	COG1178	ABC-type Fe3 transport system permease component
AAVE_RS04540	COG4970	Tfp pilus assembly protein FimT
AAVE_RS04560	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AAVE_RS04565	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AAVE_RS04570	COG1765	OsmC-like protein
AAVE_RS04575	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AAVE_RS04595	COG1473	amidohydrolase
AAVE_RS04600	COG0747	negative chemotaxis
AAVE_RS04605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AAVE_RS04610	COG0444	Belongs to the ABC transporter superfamily
AAVE_RS04615	COG4608	Belongs to the ABC transporter superfamily
AAVE_RS04620	COG0840	transmembrane signaling receptor activity
AAVE_RS04630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AAVE_RS04635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AAVE_RS04640	COG0166	Belongs to the GPI family
AAVE_RS04645	COG0459	protein refolding
AAVE_RS04650	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AAVE_RS04670	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AAVE_RS04710	COG0367	asparagine synthase
AAVE_RS04715	COG0367	asparagine synthase
AAVE_RS04735	COG1216	Glycosyl transferase, family 2
AAVE_RS04745	COG1309	transcriptional regulator
AAVE_RS04750	COG0493	'glutamate synthase
AAVE_RS04760	COG1953	Uracil, thiamine, allantoin
AAVE_RS04795	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AAVE_RS04795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AAVE_RS04800	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AAVE_RS04815	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AAVE_RS04825	COG1560	Kdo2-lipid A biosynthetic process
AAVE_RS04835	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AAVE_RS04845	COG1333	cytochrome c biogenesis protein
AAVE_RS04850	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AAVE_RS04855	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AAVE_RS04860	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AAVE_RS04890	COG1965	Belongs to the frataxin family
AAVE_RS04930	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AAVE_RS04935	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AAVE_RS04940	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AAVE_RS04960	COG0069	glutamate synthase activity
AAVE_RS04960	COG0070	glutamate synthase
AAVE_RS04960	COG0067	glutamate synthase
AAVE_RS04970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AAVE_RS04975	COG0765	amino acid transport
AAVE_RS04980	COG1126	abc transporter atp-binding protein
AAVE_RS04985	COG1127	ABC transporter
AAVE_RS04990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AAVE_RS04995	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AAVE_RS05000	COG2853	Lipoprotein
AAVE_RS05020	COG1131	(ABC) transporter
AAVE_RS05025	COG0842	Transport permease protein
AAVE_RS05030	COG5007	Belongs to the BolA IbaG family
AAVE_RS05035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AAVE_RS05040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AAVE_RS05045	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AAVE_RS05065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AAVE_RS05070	COG0131	Imidazoleglycerol-phosphate dehydratase
AAVE_RS05080	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AAVE_RS05100	COG0438	transferase activity, transferring glycosyl groups
AAVE_RS05130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AAVE_RS05135	COG1301	dicarboxylic acid transport
AAVE_RS05145	COG0107	imidazoleglycerol-phosphate synthase activity
AAVE_RS05150	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AAVE_RS05155	COG0140	phosphoribosyl-ATP diphosphatase activity
AAVE_RS05170	COG0537	adenosine 5'-monophosphoramidase activity
AAVE_RS05175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AAVE_RS05180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AAVE_RS05185	COG0805	protein transport
AAVE_RS05200	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AAVE_RS05220	COG0714	Associated with various cellular activities
AAVE_RS05225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AAVE_RS05230	COG0084	hydrolase, TatD family'
AAVE_RS05240	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AAVE_RS05245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AAVE_RS05295	COG1028	Short-chain dehydrogenase reductase Sdr
AAVE_RS05300	COG0840	transmembrane signaling receptor activity
AAVE_RS05305	COG0829	nickel cation binding
AAVE_RS05325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AAVE_RS05350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AAVE_RS05355	COG1116	anion transmembrane transporter activity
AAVE_RS05370	COG0280	phosphate acetyltransferase
AAVE_RS05370	COG0281	malic enzyme
AAVE_RS05375	COG2233	PERMEase
AAVE_RS05390	COG1953	Uracil, thiamine, allantoin
AAVE_RS05395	COG2186	Transcriptional regulator
AAVE_RS05400	COG0840	transmembrane signaling receptor activity
AAVE_RS05405	COG1301	dicarboxylic acid transport
AAVE_RS05425	COG2195	Cleaves the N-terminal amino acid of tripeptides
AAVE_RS05435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AAVE_RS05450	COG2186	Transcriptional regulator
AAVE_RS05460	COG0405	Gamma-glutamyltransferase
AAVE_RS05505	COG0251	oxidation-reduction process
AAVE_RS05525	COG5001	Diguanylate cyclase
AAVE_RS05525	COG3447	MASE1 domain protein
AAVE_RS05525	COG5002	protein histidine kinase activity
AAVE_RS05540	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AAVE_RS05555	COG3845	ABC transporter
AAVE_RS05560	COG4603	Belongs to the binding-protein-dependent transport system permease family
AAVE_RS05585	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AAVE_RS05595	COG2366	antibiotic biosynthetic process
AAVE_RS05600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AAVE_RS05615	COG0717	Belongs to the dCTP deaminase family
AAVE_RS05630	COG2321	neutral zinc metallopeptidase
AAVE_RS05635	COG0513	Belongs to the DEAD box helicase family
AAVE_RS05640	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AAVE_RS05645	COG2916	Histone family protein nucleoid-structuring protein H-NS
AAVE_RS05650	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AAVE_RS05670	COG3483	tryptophan 2,3-dioxygenase activity
AAVE_RS05680	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AAVE_RS05685	COG1522	sequence-specific DNA binding
AAVE_RS05690	COG0727	PFAM Uncharacterised protein family (UPF0153)
AAVE_RS05715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AAVE_RS05720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AAVE_RS05730	COG0579	oxidoreductase
AAVE_RS05735	COG0268	Binds directly to 16S ribosomal RNA
AAVE_RS05740	COG0728	peptidoglycan biosynthetic process
AAVE_RS05750	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AAVE_RS05750	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AAVE_RS05760	COG3022	response to hydroperoxide
AAVE_RS05765	COG1530	ribonuclease E activity
AAVE_RS05785	COG0616	signal peptide processing
AAVE_RS05785	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AAVE_RS05790	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AAVE_RS05795	COG0424	maF-like protein
AAVE_RS05800	COG1399	metal-binding, possibly nucleic acid-binding protein
AAVE_RS05805	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AAVE_RS05810	COG0416	fatty acid biosynthetic process
AAVE_RS05815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AAVE_RS05820	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AAVE_RS05825	COG1028	Short-chain dehydrogenase reductase Sdr
AAVE_RS05830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AAVE_RS05835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AAVE_RS05855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AAVE_RS05860	COG0481	GTPase activity
AAVE_RS05865	COG0681	Belongs to the peptidase S26 family
AAVE_RS05875	COG0571	ribonuclease III activity
AAVE_RS05880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AAVE_RS05885	COG1381	Involved in DNA repair and RecF pathway recombination
AAVE_RS05890	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AAVE_RS05895	COG1472	Belongs to the glycosyl hydrolase 3 family
AAVE_RS05900	COG3064	Membrane
AAVE_RS05915	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AAVE_RS05940	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AAVE_RS05955	COG0762	integral membrane protein
AAVE_RS05960	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AAVE_RS05965	COG0159	tryptophan synthase activity
AAVE_RS05970	COG0133	tryptophan synthase activity
AAVE_RS05975	COG0135	phosphoribosylanthranilate isomerase activity
AAVE_RS05980	COG0101	tRNA pseudouridine synthase activity
AAVE_RS05990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AAVE_RS06000	COG0473	3-isopropylmalate dehydrogenase activity
AAVE_RS06005	COG0066	3-isopropylmalate dehydratase activity
AAVE_RS06015	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AAVE_RS06025	COG0484	heat shock protein binding
AAVE_RS06030	COG0443	Heat shock 70 kDa protein
AAVE_RS06035	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AAVE_RS06040	COG0360	Binds together with S18 to 16S ribosomal RNA
AAVE_RS06050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AAVE_RS06055	COG0359	binds to the 23S rRNA
AAVE_RS06070	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AAVE_RS06075	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AAVE_RS06085	COG0436	Aminotransferase
AAVE_RS06100	COG1763	Mo-molybdopterin cofactor biosynthetic process
AAVE_RS06105	COG0303	'Molybdopterin
AAVE_RS06110	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AAVE_RS06115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AAVE_RS06140	COG0314	molybdopterin synthase activity
AAVE_RS06145	COG0542	response to heat
AAVE_RS06165	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AAVE_RS06175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AAVE_RS06180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AAVE_RS06190	COG0436	Aminotransferase
AAVE_RS06195	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AAVE_RS06200	COG1185	polyribonucleotide nucleotidyltransferase activity
AAVE_RS06205	COG0604	alcohol dehydrogenase
AAVE_RS06205	COG1028	Short-chain dehydrogenase reductase Sdr
AAVE_RS06205	COG3321	synthase
AAVE_RS06210	COG0149	triose-phosphate isomerase activity
AAVE_RS06225	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AAVE_RS06230	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AAVE_RS06235	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AAVE_RS06240	COG0649	NAD binding
AAVE_RS06245	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AAVE_RS06250	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AAVE_RS06255	COG1034	ATP synthesis coupled electron transport
AAVE_RS06260	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AAVE_RS06265	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AAVE_RS06275	COG0713	ATP synthesis coupled electron transport
AAVE_RS06290	COG1007	ATP synthesis coupled electron transport
AAVE_RS06310	COG1132	(ABC) transporter
AAVE_RS06355	COG0457	Tetratricopeptide repeat
AAVE_RS06355	COG0463	Glycosyl transferase, family 2
AAVE_RS06375	COG0071	Belongs to the small heat shock protein (HSP20) family
AAVE_RS06380	COG1136	(ABC) transporter
AAVE_RS06385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AAVE_RS06390	COG0702	epimerase
AAVE_RS06395	COG1733	regulation of RNA biosynthetic process
AAVE_RS06400	COG2267	carboxylic ester hydrolase activity
AAVE_RS06405	COG0584	glycerophosphoryl diester phosphodiesterase
AAVE_RS06415	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AAVE_RS06420	COG0586	Pfam SNARE associated Golgi protein
AAVE_RS06425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AAVE_RS06440	COG0860	N-Acetylmuramoyl-L-alanine amidase
AAVE_RS06445	COG0802	atpase or kinase
AAVE_RS06450	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AAVE_RS06480	COG4974	Belongs to the 'phage' integrase family
AAVE_RS06485	COG3181	Tripartite tricarboxylate transporter family receptor
AAVE_RS06490	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AAVE_RS06495	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AAVE_RS06500	COG2833	Protein of unknown function (DUF455)
AAVE_RS06510	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AAVE_RS06520	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AAVE_RS06525	COG0148	phosphopyruvate hydratase activity
AAVE_RS06545	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AAVE_RS06550	COG0504	CTP synthase activity
AAVE_RS06555	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AAVE_RS06560	COG0756	dUTP diphosphatase activity
AAVE_RS06570	COG1047	Peptidyl-prolyl cis-trans
AAVE_RS06575	COG2850	peptidyl-arginine hydroxylation
AAVE_RS06590	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AAVE_RS06595	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AAVE_RS06600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AAVE_RS06620	COG0741	lytic transglycosylase activity
AAVE_RS06630	COG0840	transmembrane signaling receptor activity
AAVE_RS06635	COG0840	transmembrane signaling receptor activity
AAVE_RS06640	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AAVE_RS06675	COG2308	Evidence 4 Homologs of previously reported genes of
AAVE_RS06695	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AAVE_RS06705	COG4628	conserved protein (DUF2132)
AAVE_RS06715	COG0657	acetylesterase activity
AAVE_RS06720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AAVE_RS06745	COG4774	siderophore transport
AAVE_RS06790	COG3634	alkyl hydroperoxide reductase activity
AAVE_RS06815	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AAVE_RS06830	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AAVE_RS06855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AAVE_RS06870	COG0583	DNA-binding transcription factor activity
AAVE_RS06875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AAVE_RS06890	COG1028	Short-chain dehydrogenase reductase Sdr
AAVE_RS06895	COG4948	Mandelate Racemase Muconate Lactonizing
AAVE_RS06935	COG0840	transmembrane signaling receptor activity
AAVE_RS06940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AAVE_RS06945	COG0358	DNA primase activity
AAVE_RS06950	COG5001	Diguanylate cyclase
AAVE_RS06950	COG3300	MHYT domain
AAVE_RS06955	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AAVE_RS06960	COG0405	Gamma-glutamyltransferase
AAVE_RS06965	COG3540	Alkaline phosphatase
AAVE_RS06975	COG0604	alcohol dehydrogenase
AAVE_RS06975	COG1028	Short-chain dehydrogenase reductase Sdr
AAVE_RS06975	COG3321	synthase
AAVE_RS06980	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AAVE_RS06985	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AAVE_RS06995	COG0564	pseudouridine synthase activity
AAVE_RS07000	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AAVE_RS07005	COG1187	pseudouridine synthase activity
AAVE_RS07010	COG0105	UTP biosynthetic process
AAVE_RS07015	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AAVE_RS07020	COG3063	Type IV pilus biogenesis stability protein PilW
AAVE_RS07030	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AAVE_RS07035	COG0124	histidyl-tRNA synthetase
AAVE_RS07050	COG1160	GTP binding
AAVE_RS07055	COG1923	regulation of RNA biosynthetic process
AAVE_RS07060	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AAVE_RS07065	COG0330	HflC and HflK could
AAVE_RS07070	COG0330	HflC and HflK could
AAVE_RS07075	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AAVE_RS07080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AAVE_RS07085	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AAVE_RS07115	COG1187	pseudouridine synthase activity
AAVE_RS07145	COG0174	glutamine synthetase
AAVE_RS07155	COG3852	Histidine kinase
AAVE_RS07160	COG2204	response regulator
AAVE_RS07170	COG0708	Exodeoxyribonuclease III
AAVE_RS07185	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AAVE_RS07195	COG0277	FAD linked oxidase domain protein
AAVE_RS07205	COG1295	ribonuclease BN
AAVE_RS07210	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AAVE_RS07235	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AAVE_RS07240	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AAVE_RS07245	COG0740	serine-type endopeptidase activity
AAVE_RS07250	COG0544	peptidyl-prolyl cis-trans isomerase activity
AAVE_RS07260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AAVE_RS07270	COG1562	ergosterol biosynthetic process
AAVE_RS07300	COG0631	protein serine/threonine phosphatase activity
AAVE_RS07315	COG2885	chlorophyll binding
AAVE_RS07380	COG1451	nucleotide metabolic process
AAVE_RS07385	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AAVE_RS07390	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AAVE_RS07395	COG2080	2 iron, 2 sulfur cluster binding
AAVE_RS07400	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AAVE_RS07415	COG0114	fumarate hydratase activity
AAVE_RS07425	COG0745	RESPONSE REGULATOR receiver
AAVE_RS07430	COG2205	protein histidine kinase activity
AAVE_RS07435	COG2113	Glycine betaine
AAVE_RS07440	COG4176	ABC-type proline glycine betaine transport system permease component
AAVE_RS07445	COG4175	Glycine betaine
AAVE_RS07455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AAVE_RS07465	COG4654	Cytochrome c, class I
AAVE_RS07475	COG0129	dihydroxy-acid dehydratase activity
AAVE_RS07490	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AAVE_RS07495	COG1802	Transcriptional regulator
AAVE_RS07520	COG0318	PFAM AMP-dependent synthetase and ligase
AAVE_RS07540	COG0589	response to stress
AAVE_RS07550	COG2217	Heavy metal translocating P-type atpase
AAVE_RS07560	COG3278	Belongs to the heme-copper respiratory oxidase family
AAVE_RS07595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AAVE_RS07600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AAVE_RS07610	COG3437	response regulator, receiver
AAVE_RS07630	COG4206	TonB-dependent receptor
AAVE_RS07635	COG1797	cobyrinic acid a,c-diamide synthase activity
AAVE_RS07650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AAVE_RS07655	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AAVE_RS07660	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AAVE_RS07665	COG0778	Nitroreductase
AAVE_RS07670	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AAVE_RS07700	COG1028	Short-chain dehydrogenase reductase Sdr
AAVE_RS07705	COG1492	cobalamin metabolic process
AAVE_RS07710	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AAVE_RS07730	COG3039	Transposase
AAVE_RS07735	COG0477	Major facilitator Superfamily
AAVE_RS07750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AAVE_RS07755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AAVE_RS07760	COG2900	Belongs to the SlyX family
AAVE_RS07765	COG0667	Aldo Keto reductase
AAVE_RS07775	COG0513	Belongs to the DEAD box helicase family
AAVE_RS07800	COG1959	2 iron, 2 sulfur cluster binding
AAVE_RS07805	COG0583	DNA-binding transcription factor activity
AAVE_RS07820	COG0560	Phosphoserine phosphatase
AAVE_RS07830	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AAVE_RS07840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AAVE_RS07845	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AAVE_RS07845	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AAVE_RS07850	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AAVE_RS07850	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AAVE_RS07870	COG1028	Short-chain dehydrogenase reductase Sdr
AAVE_RS07880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AAVE_RS07915	COG0693	protein deglycase activity
AAVE_RS07925	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AAVE_RS07940	COG1475	DNA binding
AAVE_RS08085	COG1196	nuclear chromosome segregation
AAVE_RS08175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AAVE_RS08190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AAVE_RS08205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AAVE_RS08210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AAVE_RS08230	COG1446	asparaginase
AAVE_RS08235	COG4172	Belongs to the ABC transporter superfamily
AAVE_RS08245	COG0601	transmembrane transport
AAVE_RS08250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AAVE_RS08270	COG0322	excinuclease ABC activity
AAVE_RS08305	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AAVE_RS08460	COG5484	DNA packaging
AAVE_RS08460	COG3728	DNA packaging
AAVE_RS08920	COG1196	nuclear chromosome segregation
AAVE_RS08995	COG4651	solute:proton antiporter activity
AAVE_RS08995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AAVE_RS09005	COG0513	Belongs to the DEAD box helicase family
AAVE_RS09015	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AAVE_RS09020	COG0488	(ABC) transporter
AAVE_RS09035	COG3191	aminopeptidase activity
AAVE_RS09060	COG2132	Multicopper oxidase
AAVE_RS09090	COG0789	Transcriptional regulator
AAVE_RS09115	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AAVE_RS09115	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AAVE_RS09120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AAVE_RS09125	COG0052	Belongs to the universal ribosomal protein uS2 family
AAVE_RS09130	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AAVE_RS09135	COG0528	UMP kinase activity
AAVE_RS09140	COG0233	cytoplasmic translational termination
AAVE_RS09150	COG0575	Belongs to the CDS family
AAVE_RS09155	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AAVE_RS09160	COG0750	zinc metalloprotease
AAVE_RS09175	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AAVE_RS09180	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AAVE_RS09185	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AAVE_RS09190	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AAVE_RS09195	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AAVE_RS09200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AAVE_RS09205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AAVE_RS09210	COG3181	Tripartite tricarboxylate transporter family receptor
AAVE_RS09215	COG1960	acyl-CoA dehydrogenase activity
AAVE_RS09220	COG0583	DNA-binding transcription factor activity
AAVE_RS09230	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AAVE_RS09235	COG0308	aminopeptidase N
AAVE_RS09245	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AAVE_RS09250	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AAVE_RS09255	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AAVE_RS09260	COG0667	Aldo Keto reductase
AAVE_RS09265	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AAVE_RS09270	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AAVE_RS09280	COG3577	Aspartyl protease
AAVE_RS09285	COG1666	GTP binding
AAVE_RS09295	COG0137	argininosuccinate synthase activity
AAVE_RS09300	COG3123	guanosine phosphorylase activity
AAVE_RS09310	COG1393	Belongs to the ArsC family
AAVE_RS09315	COG0285	dihydrofolate synthase activity
AAVE_RS09325	COG1286	toxin biosynthetic process
AAVE_RS09340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AAVE_RS09380	COG2814	Major facilitator Superfamily
AAVE_RS09385	COG2814	Major facilitator Superfamily
AAVE_RS09405	COG1573	uracil-dna glycosylase
AAVE_RS09410	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AAVE_RS09415	COG0840	transmembrane signaling receptor activity
AAVE_RS09420	COG0559	Belongs to the binding-protein-dependent transport system permease family
AAVE_RS09440	COG2885	chlorophyll binding
AAVE_RS09440	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AAVE_RS09445	COG1392	Phosphate transport regulator
AAVE_RS09450	COG0306	phosphate transporter
AAVE_RS09465	COG0228	four-way junction DNA binding
AAVE_RS09470	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AAVE_RS09475	COG0336	Belongs to the RNA methyltransferase TrmD family
AAVE_RS09480	COG0335	large ribosomal subunit rRNA binding
AAVE_RS09490	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AAVE_RS09495	COG1162	GTPase activity
AAVE_RS09500	COG2154	pterin-4-alpha-carbinolamine dehydratase
AAVE_RS09510	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AAVE_RS09515	COG0513	Belongs to the DEAD box helicase family
AAVE_RS09520	COG5001	Diguanylate cyclase
AAVE_RS09520	COG5002	protein histidine kinase activity
AAVE_RS09520	COG3447	MASE1 domain protein
AAVE_RS09525	COG2814	Major facilitator Superfamily
AAVE_RS09540	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AAVE_RS09545	COG5002	protein histidine kinase activity
AAVE_RS09550	COG2204	response regulator
AAVE_RS09595	COG0516	GMP reductase activity
AAVE_RS09680	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AAVE_RS09720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AAVE_RS09725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AAVE_RS09755	COG0412	Dienelactone hydrolase
AAVE_RS09765	COG0165	Argininosuccinate lyase
AAVE_RS09780	COG3275	phosphorelay sensor kinase activity
AAVE_RS09785	COG0165	Argininosuccinate lyase
AAVE_RS09825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AAVE_RS09835	COG1304	FMN binding
AAVE_RS09840	COG0840	transmembrane signaling receptor activity
AAVE_RS09860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AAVE_RS09885	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AAVE_RS09890	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AAVE_RS09900	COG0617	tRNA 3'-terminal CCA addition
AAVE_RS09940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AAVE_RS09945	COG1960	acyl-CoA dehydrogenase activity
AAVE_RS09950	COG0583	DNA-binding transcription factor activity
AAVE_RS09975	COG2816	NAD+ diphosphatase activity
AAVE_RS09980	COG0425	Belongs to the sulfur carrier protein TusA family
AAVE_RS09990	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AAVE_RS09995	COG0525	valine-tRNA ligase activity
AAVE_RS10000	COG0501	Belongs to the peptidase M48B family
AAVE_RS10010	COG0488	(ABC) transporter
AAVE_RS10030	COG0181	hydroxymethylbilane synthase activity
AAVE_RS10035	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AAVE_RS10040	COG1289	transmembrane transporter activity
AAVE_RS10045	COG0628	permease
AAVE_RS10100	COG1722	exodeoxyribonuclease VII activity
AAVE_RS10105	COG0142	geranyltranstransferase activity
AAVE_RS10110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AAVE_RS10115	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AAVE_RS10140	COG0668	transmembrane transport
AAVE_RS10145	COG0366	Alpha amylase catalytic
AAVE_RS10150	COG0366	Alpha amylase catalytic
AAVE_RS10155	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AAVE_RS10160	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AAVE_RS10165	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AAVE_RS10185	COG2005	Transcriptional regulator
AAVE_RS10185	COG3585	molybdate ion transport
AAVE_RS10195	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AAVE_RS10210	COG3279	Response regulator of the LytR AlgR family
AAVE_RS10215	COG3275	phosphorelay sensor kinase activity
AAVE_RS10245	COG1968	undecaprenyl-diphosphatase activity
AAVE_RS10250	COG3447	MASE1 domain protein
AAVE_RS10250	COG5001	Diguanylate cyclase
AAVE_RS10250	COG5002	protein histidine kinase activity
AAVE_RS10275	COG3209	COG3209 Rhs family protein
AAVE_RS10285	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AAVE_RS10290	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AAVE_RS10345	COG2205	protein histidine kinase activity
AAVE_RS10345	COG0784	Response regulator, receiver
AAVE_RS10345	COG5002	protein histidine kinase activity
AAVE_RS10350	COG3437	response regulator, receiver
AAVE_RS10360	COG1132	(ABC) transporter
AAVE_RS10380	COG0483	inositol monophosphate 1-phosphatase activity
AAVE_RS10395	COG4555	ABC transporter
AAVE_RS10400	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AAVE_RS10410	COG1045	serine acetyltransferase
AAVE_RS10415	COG0521	Mo-molybdopterin cofactor biosynthetic process
AAVE_RS10420	COG3028	Belongs to the UPF0307 family
AAVE_RS10425	COG0312	modulator of DNA gyrase
AAVE_RS10440	COG2721	sulfolactate sulfo-lyase activity
AAVE_RS10455	COG0477	Major facilitator Superfamily
AAVE_RS10460	COG1752	Esterase of the alpha-beta hydrolase superfamily
AAVE_RS10465	COG0473	3-isopropylmalate dehydrogenase activity
AAVE_RS10470	COG0583	DNA-binding transcription factor activity
AAVE_RS10480	COG0625	glutathione transferase activity
AAVE_RS10485	COG1610	YqeY-like protein
AAVE_RS10490	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AAVE_RS10505	COG0640	Transcriptional regulator
AAVE_RS10510	COG2081	HI0933 family
AAVE_RS10525	COG0288	reversible hydration of carbon dioxide
AAVE_RS10530	COG1607	acyl-coa hydrolase
AAVE_RS10535	COG5297	Belongs to the glycosyl hydrolase family 6
AAVE_RS10535	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AAVE_RS10545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AAVE_RS10550	COG0243	molybdopterin cofactor binding
AAVE_RS10560	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AAVE_RS10565	COG0840	transmembrane signaling receptor activity
AAVE_RS10580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AAVE_RS10590	COG0840	transmembrane signaling receptor activity
AAVE_RS10595	COG0516	GMP reductase activity
AAVE_RS10595	COG0517	IMP dehydrogenase activity
AAVE_RS10600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AAVE_RS10605	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AAVE_RS10620	COG0840	transmembrane signaling receptor activity
AAVE_RS10630	COG0745	RESPONSE REGULATOR receiver
AAVE_RS10645	COG2223	nitrite transmembrane transporter activity
AAVE_RS10690	COG0626	cystathionine gamma-synthase activity
AAVE_RS10700	COG0724	RNA recognition motif
AAVE_RS10710	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AAVE_RS10715	COG1116	anion transmembrane transporter activity
AAVE_RS10720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AAVE_RS10725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AAVE_RS10745	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AAVE_RS10760	COG0683	leucine binding
AAVE_RS10790	COG2951	lytic endotransglycosylase activity
AAVE_RS10805	COG0714	Associated with various cellular activities
AAVE_RS10810	COG0123	including yeast histone deacetylase and acetoin utilization protein
AAVE_RS10815	COG1024	Enoyl-CoA hydratase
AAVE_RS10820	COG1511	domain protein
AAVE_RS10820	COG3264	Mechanosensitive ion channel
AAVE_RS10835	COG1960	acyl-CoA dehydrogenase activity
AAVE_RS10880	COG1473	amidohydrolase
AAVE_RS10885	COG1522	sequence-specific DNA binding
AAVE_RS10895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AAVE_RS10915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AAVE_RS10930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AAVE_RS10940	COG0473	3-isopropylmalate dehydrogenase activity
AAVE_RS10950	COG2194	sulfuric ester hydrolase activity
AAVE_RS10955	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AAVE_RS10965	COG4977	sequence-specific DNA binding
AAVE_RS10970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AAVE_RS10980	COG0372	Belongs to the citrate synthase family
AAVE_RS10985	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AAVE_RS10990	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AAVE_RS10995	COG1053	succinate dehydrogenase
AAVE_RS11010	COG2188	Transcriptional regulator
AAVE_RS11015	COG0039	L-malate dehydrogenase activity
AAVE_RS11020	COG4106	trans-aconitate 2-methyltransferase activity
AAVE_RS11035	COG1049	propionate catabolic process, 2-methylcitrate cycle
AAVE_RS11040	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AAVE_RS11055	COG0826	peptidase U32
AAVE_RS11060	COG0583	DNA-binding transcription factor activity
AAVE_RS11085	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AAVE_RS11090	COG1845	cytochrome c oxidase, subunit III
AAVE_RS11095	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AAVE_RS11100	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AAVE_RS11105	COG0477	Major facilitator Superfamily
AAVE_RS11125	COG0824	Thioesterase
AAVE_RS11130	COG0436	Aminotransferase
AAVE_RS11135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AAVE_RS11140	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AAVE_RS11155	COG0633	Ferredoxin
AAVE_RS11165	COG2202	Pas domain
AAVE_RS11165	COG2205	protein histidine kinase activity
AAVE_RS11175	COG0745	RESPONSE REGULATOR receiver
AAVE_RS11180	COG2201	protein-glutamate methylesterase activity
AAVE_RS11200	COG1289	transmembrane transporter activity
AAVE_RS11205	COG4948	Mandelate Racemase Muconate Lactonizing
AAVE_RS11210	COG0800	Aldolase
AAVE_RS11215	COG3734	2-keto-3-deoxy-galactonokinase
AAVE_RS11230	COG1172	Belongs to the binding-protein-dependent transport system permease family
AAVE_RS11235	COG1172	Belongs to the binding-protein-dependent transport system permease family
AAVE_RS11245	COG4214	carbohydrate transport
AAVE_RS11255	COG4213	ABC transporter substrate-binding protein
AAVE_RS11260	COG1879	ABC-type sugar transport system periplasmic component
AAVE_RS11280	COG3386	PFAM SMP-30 Gluconolaconase
AAVE_RS11295	COG2918	glutathione biosynthetic process
AAVE_RS11310	COG5002	protein histidine kinase activity
AAVE_RS11325	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AAVE_RS11345	COG2814	Major facilitator Superfamily
AAVE_RS11360	COG1285	pathogenesis
AAVE_RS11365	COG0564	pseudouridine synthase activity
AAVE_RS11390	COG1653	transport
AAVE_RS11395	COG0840	transmembrane signaling receptor activity
AAVE_RS11425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AAVE_RS11450	COG1309	transcriptional regulator
AAVE_RS11465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AAVE_RS11475	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AAVE_RS11490	COG3384	dioxygenase
AAVE_RS11510	COG1522	sequence-specific DNA binding
AAVE_RS11565	COG0215	cysteine-tRNA ligase activity
AAVE_RS11580	COG0037	tRNA processing
AAVE_RS11585	COG0527	aspartate kinase activity
AAVE_RS11665	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AAVE_RS11950	COG4128	Pfam Zonular occludens toxin
AAVE_RS11960	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AAVE_RS11975	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AAVE_RS12060	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AAVE_RS12095	COG3048	D-serine ammonia-lyase activity
AAVE_RS12100	COG3181	Tripartite tricarboxylate transporter family receptor
AAVE_RS12105	COG0154	amidase activity
AAVE_RS12125	COG1739	Uncharacterized protein family UPF0029
AAVE_RS12140	COG0840	transmembrane signaling receptor activity
AAVE_RS12155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AAVE_RS12165	COG0556	nucleotide-excision repair
AAVE_RS12170	COG1959	2 iron, 2 sulfur cluster binding
AAVE_RS12175	COG1104	cysteine desulfurase activity
AAVE_RS12180	COG0822	iron-sulfur transferase activity
AAVE_RS12190	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AAVE_RS12195	COG0443	Heat shock 70 kDa protein
AAVE_RS12200	COG0633	Ferredoxin
AAVE_RS12225	COG0579	oxidoreductase
AAVE_RS12245	COG0167	dihydroorotate dehydrogenase activity
AAVE_RS12250	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AAVE_RS12265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AAVE_RS12270	COG4566	intracellular signal transduction
AAVE_RS12280	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AAVE_RS12285	COG0508	dehydrogenase complex catalyzes the overall conversion of
AAVE_RS12290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AAVE_RS12315	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AAVE_RS12320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AAVE_RS12330	COG0515	serine threonine protein kinase
AAVE_RS12360	COG3243	poly(R)-hydroxyalkanoic acid synthase
AAVE_RS12365	COG0183	Belongs to the thiolase family
AAVE_RS12370	COG1028	Short-chain dehydrogenase reductase Sdr
AAVE_RS12375	COG0488	(ABC) transporter
AAVE_RS12380	COG2890	protein-(glutamine-N5) methyltransferase activity
AAVE_RS12385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AAVE_RS12395	COG2171	N-acyltransferase activity
AAVE_RS12405	COG0840	transmembrane signaling receptor activity
AAVE_RS12410	COG2878	Part of a membrane complex involved in electron transport
AAVE_RS12430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AAVE_RS12445	COG3039	Transposase
AAVE_RS12460	COG0840	transmembrane signaling receptor activity
AAVE_RS12520	COG1802	Transcriptional regulator
AAVE_RS12525	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AAVE_RS12525	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AAVE_RS12535	COG1703	isobutyryl-CoA mutase activity
AAVE_RS12540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AAVE_RS12550	COG4770	biotin carboxylase activity
AAVE_RS12565	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AAVE_RS12605	COG5002	protein histidine kinase activity
AAVE_RS12620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AAVE_RS12635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AAVE_RS12640	COG0583	DNA-binding transcription factor activity
AAVE_RS12645	COG2814	Major facilitator Superfamily
AAVE_RS12655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AAVE_RS12660	COG2011	ABC-type metal ion transport system permease component
AAVE_RS12680	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AAVE_RS12700	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AAVE_RS12705	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AAVE_RS12710	COG4208	sulfate ABC transporter
AAVE_RS12715	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AAVE_RS12720	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AAVE_RS12725	COG1054	Belongs to the UPF0176 family
AAVE_RS12740	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AAVE_RS12740	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AAVE_RS12745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AAVE_RS12755	COG1643	Atp-dependent helicase
AAVE_RS12765	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AAVE_RS12770	COG0252	asparaginase activity
AAVE_RS12780	COG0563	adenylate kinase activity
AAVE_RS12785	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AAVE_RS12790	COG2835	tetraacyldisaccharide 4'-kinase activity
AAVE_RS12795	COG1663	tetraacyldisaccharide 4'-kinase activity
AAVE_RS12800	COG0848	biopolymer transport protein
AAVE_RS12805	COG0811	peptide transport
AAVE_RS12810	COG1570	exodeoxyribonuclease VII activity
AAVE_RS12815	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AAVE_RS12845	COG0625	glutathione transferase activity
AAVE_RS12850	COG1942	4-Oxalocrotonate Tautomerase
AAVE_RS12860	COG2814	Major facilitator Superfamily
AAVE_RS12865	COG0789	Transcriptional regulator
AAVE_RS12905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AAVE_RS12910	COG3181	Tripartite tricarboxylate transporter family receptor
AAVE_RS12920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AAVE_RS12930	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AAVE_RS12945	COG2721	sulfolactate sulfo-lyase activity
AAVE_RS12960	COG4772	TonB-dependent receptor
AAVE_RS12965	COG2032	superoxide dismutase activity
AAVE_RS12980	COG1960	acyl-CoA dehydrogenase activity
AAVE_RS13010	COG1113	amino acid transport
AAVE_RS13020	COG0505	Belongs to the CarA family
AAVE_RS13025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AAVE_RS13030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AAVE_RS13045	COG1534	Rna-binding protein
AAVE_RS13050	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AAVE_RS13055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AAVE_RS13065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AAVE_RS13095	COG0248	Ppx GppA phosphatase
AAVE_RS13100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AAVE_RS13105	COG0573	inorganic phosphate transmembrane transporter activity
AAVE_RS13110	COG0581	inorganic phosphate transmembrane transporter activity
AAVE_RS13115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AAVE_RS13120	COG0704	Plays a role in the regulation of phosphate uptake
AAVE_RS13135	COG0534	Mate efflux family protein
AAVE_RS13145	COG0254	rRNA binding
AAVE_RS13150	COG0420	3'-5' exonuclease activity
AAVE_RS13155	COG0419	ATPase involved in DNA repair
AAVE_RS13160	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AAVE_RS13175	COG1074	ATP-dependent DNA helicase activity
AAVE_RS13180	COG2081	HI0933 family
AAVE_RS13190	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AAVE_RS13195	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AAVE_RS13200	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AAVE_RS13215	COG1388	LysM domain
AAVE_RS13215	COG0741	lytic transglycosylase activity
AAVE_RS13220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AAVE_RS13225	COG2226	methyltransferase
AAVE_RS13230	COG0328	RNA-DNA hybrid ribonuclease activity
AAVE_RS13245	COG0303	'Molybdopterin
AAVE_RS13255	COG0746	molybdenum cofactor guanylyltransferase activity
AAVE_RS13260	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AAVE_RS13285	COG1012	belongs to the aldehyde dehydrogenase family
AAVE_RS13310	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AAVE_RS13325	COG0587	DNA-directed DNA polymerase activity
AAVE_RS13330	COG2982	Protein involved in outer membrane biogenesis
AAVE_RS13335	COG0564	pseudouridine synthase activity
AAVE_RS13345	COG2894	cell division
AAVE_RS13390	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AAVE_RS13565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AAVE_RS13580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AAVE_RS13600	COG1196	nuclear chromosome segregation
AAVE_RS13600	COG0741	lytic transglycosylase activity
AAVE_RS13600	COG0739	heme binding
AAVE_RS13620	COG0587	DNA-directed DNA polymerase activity
AAVE_RS13690	COG4453	Protein conserved in bacteria
AAVE_RS13845	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AAVE_RS13855	COG0431	NADPH-dependent FMN reductase
AAVE_RS13860	COG0583	DNA-binding transcription factor activity
AAVE_RS13900	COG1028	Short-chain dehydrogenase reductase Sdr
AAVE_RS13905	COG0346	lactoylglutathione lyase activity
AAVE_RS13915	COG0800	Aldolase
AAVE_RS13925	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AAVE_RS13930	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AAVE_RS13935	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AAVE_RS13940	COG3265	gluconokinase activity
AAVE_RS13945	COG1609	Transcriptional regulator
AAVE_RS13970	COG0259	pyridoxamine-phosphate oxidase activity
AAVE_RS13985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AAVE_RS13990	COG4771	TonB-dependent receptor
AAVE_RS14015	COG1136	(ABC) transporter
AAVE_RS14025	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AAVE_RS14030	COG1309	transcriptional regulator
AAVE_RS14050	COG0045	succinate-CoA ligase (ADP-forming) activity
AAVE_RS14050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AAVE_RS14050	COG1042	CoA-binding domain protein
AAVE_RS14100	COG2133	pyrroloquinoline quinone binding
AAVE_RS14105	COG0791	NLP P60 protein
AAVE_RS14120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AAVE_RS14145	COG3209	COG3209 Rhs family protein
AAVE_RS14160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AAVE_RS14170	COG1196	nuclear chromosome segregation
AAVE_RS14180	COG1742	UPF0060 membrane protein
AAVE_RS14190	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AAVE_RS14195	COG1132	(ABC) transporter
AAVE_RS14215	COG0789	Transcriptional regulator
AAVE_RS14220	COG0776	regulation of translation
AAVE_RS14225	COG0072	phenylalanine-tRNA ligase activity
AAVE_RS14225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AAVE_RS14230	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AAVE_RS14235	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AAVE_RS14240	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AAVE_RS14245	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AAVE_RS14250	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AAVE_RS14255	COG2224	Isocitrate lyase
AAVE_RS14270	COG1522	sequence-specific DNA binding
AAVE_RS14275	COG0697	spore germination
AAVE_RS14285	COG1840	ABC-type Fe3 transport system, periplasmic component
AAVE_RS14305	COG2153	protein acetylation
AAVE_RS14310	COG2130	NADP-dependent
AAVE_RS14335	COG1960	acyl-CoA dehydrogenase activity
AAVE_RS14340	COG2050	protein possibly involved in aromatic compounds catabolism
AAVE_RS14345	COG0183	Belongs to the thiolase family
AAVE_RS14350	COG1024	Enoyl-CoA hydratase
AAVE_RS14350	COG1250	3-hydroxyacyl-CoA dehydrogenase
AAVE_RS14615	COG3706	GGDEF domain
AAVE_RS14640	COG0411	ABC transporter
AAVE_RS14650	COG0559	Belongs to the binding-protein-dependent transport system permease family
AAVE_RS14710	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AAVE_RS14720	COG0318	PFAM AMP-dependent synthetase and ligase
AAVE_RS14725	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AAVE_RS14730	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AAVE_RS14735	COG2917	probably involved in intracellular septation
AAVE_RS14745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AAVE_RS14765	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AAVE_RS14770	COG0688	phosphatidylethanolamine metabolic process
AAVE_RS14785	COG5006	permease, DMT superfamily
AAVE_RS14800	COG1228	amidohydrolase
AAVE_RS14815	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AAVE_RS14820	COG2986	histidine ammonia-lyase
AAVE_RS14825	COG2188	Transcriptional regulator
AAVE_RS14835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AAVE_RS14845	COG1366	Belongs to the anti-sigma-factor antagonist family
AAVE_RS14850	COG1366	Belongs to the anti-sigma-factor antagonist family
AAVE_RS14855	COG2172	sigma factor antagonist activity
AAVE_RS14865	COG2205	protein histidine kinase activity
AAVE_RS14870	COG2205	protein histidine kinase activity
AAVE_RS14875	COG4191	Histidine kinase
AAVE_RS14875	COG0784	Response regulator, receiver
AAVE_RS14905	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AAVE_RS14925	COG0297	glycogen (starch) synthase activity
AAVE_RS14930	COG1028	Short-chain dehydrogenase reductase Sdr
AAVE_RS14935	COG0557	exoribonuclease II activity
AAVE_RS14960	COG0741	lytic transglycosylase activity
AAVE_RS14965	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AAVE_RS14970	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AAVE_RS14980	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AAVE_RS14985	COG1125	glycine betaine transport
AAVE_RS14985	COG0517	IMP dehydrogenase activity
AAVE_RS15000	COG1011	Hydrolase
AAVE_RS15005	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AAVE_RS15010	COG5002	protein histidine kinase activity
AAVE_RS15060	COG3181	Tripartite tricarboxylate transporter family receptor
AAVE_RS15070	COG0642	Histidine kinase
AAVE_RS15085	COG0667	Aldo Keto reductase
AAVE_RS15090	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AAVE_RS15095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AAVE_RS15100	COG4181	ATPase activity
AAVE_RS15140	COG1054	Belongs to the UPF0176 family
AAVE_RS15145	COG1741	Belongs to the pirin family
AAVE_RS15155	COG1741	Belongs to the pirin family
AAVE_RS15160	COG0583	DNA-binding transcription factor activity
AAVE_RS15170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AAVE_RS15175	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AAVE_RS15185	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AAVE_RS15205	COG0583	DNA-binding transcription factor activity
AAVE_RS15215	COG1116	anion transmembrane transporter activity
AAVE_RS15220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AAVE_RS15230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AAVE_RS15240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AAVE_RS15250	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AAVE_RS15255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AAVE_RS15255	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AAVE_RS15270	COG0730	response to heat
AAVE_RS15285	COG0175	sulfate reduction
AAVE_RS15290	COG2895	sulfate adenylyltransferase (ATP) activity
AAVE_RS15290	COG0529	Catalyzes the synthesis of activated sulfate
AAVE_RS15295	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AAVE_RS15300	COG0492	ferredoxin-NADP+ reductase activity
AAVE_RS15345	COG0351	phosphomethylpyrimidine kinase
AAVE_RS15360	COG2022	thiamine diphosphate biosynthetic process
AAVE_RS15375	COG1250	3-hydroxyacyl-CoA dehydrogenase
AAVE_RS15380	COG1024	Enoyl-CoA hydratase
AAVE_RS15395	COG1960	acyl-CoA dehydrogenase activity
AAVE_RS15410	COG1619	proteins homologs of microcin C7 resistance protein MccF
AAVE_RS15435	COG0826	peptidase U32
AAVE_RS15445	COG4946	Tricorn protease homolog
AAVE_RS15445	COG1506	peptidase
AAVE_RS15445	COG0823	Involved in the tonB-independent uptake of proteins
AAVE_RS15455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AAVE_RS15460	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AAVE_RS15475	COG3047	cAMP biosynthetic process
AAVE_RS15480	COG2354	Protein conserved in bacteria
AAVE_RS15485	COG3300	MHYT domain
AAVE_RS15485	COG5001	Diguanylate cyclase
AAVE_RS15495	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AAVE_RS15495	COG0047	phosphoribosylformylglycinamidine synthase activity
AAVE_RS15500	COG0024	Methionine aminopeptidase
AAVE_RS15505	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AAVE_RS15510	COG0242	peptide deformylase activity
AAVE_RS15515	COG2832	Protein of unknown function (DUF454)
AAVE_RS15530	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AAVE_RS15535	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AAVE_RS15540	COG1414	Transcriptional regulator
AAVE_RS15550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AAVE_RS15555	COG1183	phosphatidylcholine synthase activity
AAVE_RS15560	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AAVE_RS15565	COG0440	acetolactate synthase activity
AAVE_RS15570	COG0028	Belongs to the TPP enzyme family
AAVE_RS15575	COG1595	DNA-templated transcription, initiation
AAVE_RS15595	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AAVE_RS15605	COG0347	Belongs to the P(II) protein family
AAVE_RS15620	COG0583	DNA-binding transcription factor activity
AAVE_RS15630	COG3181	Tripartite tricarboxylate transporter family receptor
AAVE_RS15635	COG0835	chemotaxis
AAVE_RS15660	COG1252	NADH dehydrogenase
AAVE_RS15670	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AAVE_RS15700	COG1028	Short-chain dehydrogenase reductase Sdr
AAVE_RS15720	COG4120	Belongs to the binding-protein-dependent transport system permease family
AAVE_RS15735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AAVE_RS15740	COG0509	glycine decarboxylation via glycine cleavage system
AAVE_RS15745	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AAVE_RS15745	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AAVE_RS15750	COG0545	Peptidyl-prolyl cis-trans isomerase
AAVE_RS15760	COG0564	pseudouridine synthase activity
AAVE_RS15765	COG1028	Short-chain dehydrogenase reductase Sdr
AAVE_RS15780	COG0589	response to stress
AAVE_RS15795	COG0318	PFAM AMP-dependent synthetase and ligase
AAVE_RS15820	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AAVE_RS15840	COG0583	DNA-binding transcription factor activity
AAVE_RS15845	COG0436	Aminotransferase
AAVE_RS15880	COG0683	leucine binding
AAVE_RS15890	COG1960	acyl-CoA dehydrogenase activity
AAVE_RS15895	COG1024	Enoyl-CoA hydratase
AAVE_RS15905	COG1028	Short-chain dehydrogenase reductase Sdr
AAVE_RS15920	COG0596	Alpha beta hydrolase
AAVE_RS15925	COG2205	protein histidine kinase activity
AAVE_RS15935	COG3593	DNA synthesis involved in DNA repair
AAVE_RS15940	COG0210	DNA helicase
AAVE_RS15990	COG1530	ribonuclease E activity
AAVE_RS15995	COG0424	maF-like protein
AAVE_RS16005	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AAVE_RS16010	COG0799	negative regulation of ribosome biogenesis
AAVE_RS16015	COG0408	coproporphyrinogen oxidase activity
AAVE_RS16020	COG0151	Belongs to the GarS family
AAVE_RS16025	COG0217	transcriptional regulatory protein
AAVE_RS16030	COG0433	COG0433 Predicted ATPase
AAVE_RS16055	COG0277	FAD linked oxidase domain protein
AAVE_RS16060	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AAVE_RS16085	COG0625	glutathione transferase activity
AAVE_RS16100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AAVE_RS16115	COG0402	S-adenosylhomocysteine deaminase activity
AAVE_RS16150	COG0484	heat shock protein binding
AAVE_RS16160	COG1012	belongs to the aldehyde dehydrogenase family
AAVE_RS16180	COG3284	Transcriptional regulator
AAVE_RS16190	COG2925	Exonuclease
AAVE_RS16195	COG2951	lytic endotransglycosylase activity
AAVE_RS16200	COG0542	response to heat
AAVE_RS16205	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AAVE_RS16220	COG1199	ATP-dependent helicase activity
AAVE_RS16235	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AAVE_RS16240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AAVE_RS16245	COG0508	dehydrogenase complex catalyzes the overall conversion of
AAVE_RS16250	COG0567	Dehydrogenase, E1 component
AAVE_RS16255	COG0628	permease
AAVE_RS16260	COG3447	MASE1 domain protein
AAVE_RS16260	COG5001	Diguanylate cyclase
AAVE_RS16260	COG5002	protein histidine kinase activity
AAVE_RS16265	COG4172	Belongs to the ABC transporter superfamily
AAVE_RS16270	COG4239	(ABC) transporter, permease
AAVE_RS16275	COG4174	ABC transporter (Permease)
AAVE_RS16280	COG4166	transmembrane transport
AAVE_RS16290	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AAVE_RS16380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AAVE_RS16395	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AAVE_RS16400	COG0077	Prephenate dehydratase
AAVE_RS16400	COG1605	Chorismate mutase
AAVE_RS16405	COG0287	Prephenate dehydrogenase
AAVE_RS16410	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AAVE_RS16420	COG0776	regulation of translation
AAVE_RS16430	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AAVE_RS16435	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AAVE_RS16435	COG2111	Na H antiporter
AAVE_RS16440	COG1006	Multisubunit Na H antiporter MnhC subunit
AAVE_RS16445	COG0651	ATP synthesis coupled electron transport
AAVE_RS16455	COG2212	antiporter activity
AAVE_RS16490	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AAVE_RS16515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AAVE_RS16520	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AAVE_RS16525	COG0405	Gamma-glutamyltransferase
AAVE_RS16565	COG3193	protein, possibly involved in utilization of glycolate and propanediol
AAVE_RS16570	COG0670	Belongs to the BI1 family
AAVE_RS16580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AAVE_RS16595	COG0506	proline dehydrogenase activity
AAVE_RS16595	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AAVE_RS16595	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AAVE_RS16605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AAVE_RS16615	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AAVE_RS16620	COG4774	siderophore transport
AAVE_RS16640	COG3181	Tripartite tricarboxylate transporter family receptor
AAVE_RS16655	COG0494	nUDIX hydrolase
AAVE_RS16660	COG1278	Cold shock
AAVE_RS16675	COG0492	ferredoxin-NADP+ reductase activity
AAVE_RS16680	COG2226	methyltransferase
AAVE_RS16705	COG3209	COG3209 Rhs family protein
AAVE_RS16725	COG1028	Short-chain dehydrogenase reductase Sdr
AAVE_RS16735	COG0583	DNA-binding transcription factor activity
AAVE_RS16775	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AAVE_RS16805	COG0582	viral genome integration into host DNA
AAVE_RS16810	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AAVE_RS16810	COG0519	Catalyzes the synthesis of GMP from XMP
AAVE_RS16835	COG2914	Belongs to the UPF0125 (RnfH) family
AAVE_RS16845	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AAVE_RS16865	COG1024	Enoyl-CoA hydratase
AAVE_RS16870	COG1253	flavin adenine dinucleotide binding
AAVE_RS16880	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AAVE_RS16885	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AAVE_RS16890	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AAVE_RS16895	COG0195	Participates in both transcription termination and antitermination
AAVE_RS16900	COG0779	Required for maturation of 30S ribosomal subunits
AAVE_RS16910	COG2010	Cytochrome c
AAVE_RS16910	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AAVE_RS16975	COG2423	ornithine cyclodeaminase activity
AAVE_RS16990	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AAVE_RS17000	COG2885	chlorophyll binding
AAVE_RS17005	COG0823	Involved in the tonB-independent uptake of proteins
AAVE_RS17010	COG1132	(ABC) transporter
AAVE_RS17020	COG0084	hydrolase, TatD family'
AAVE_RS17035	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AAVE_RS17040	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AAVE_RS17055	COG0657	acetylesterase activity
AAVE_RS17065	COG1454	alcohol dehydrogenase
AAVE_RS17080	COG2183	response to ionizing radiation
AAVE_RS17100	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AAVE_RS17105	COG1674	ftsk spoiiie
AAVE_RS17110	COG0492	ferredoxin-NADP+ reductase activity
AAVE_RS17115	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AAVE_RS17120	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AAVE_RS17125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AAVE_RS17140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AAVE_RS17140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AAVE_RS17145	COG3866	Pectate lyase
AAVE_RS17160	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AAVE_RS17165	COG3132	Protein of unknown function, DUF480
AAVE_RS17170	COG1960	acyl-CoA dehydrogenase activity
AAVE_RS17190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AAVE_RS17195	COG0840	transmembrane signaling receptor activity
AAVE_RS17200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AAVE_RS17210	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AAVE_RS17220	COG0196	riboflavin kinase activity
AAVE_RS17230	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AAVE_RS17240	COG1609	Transcriptional regulator
AAVE_RS17250	COG4149	molybdate abc transporter
AAVE_RS17255	COG1177	transmembrane transport
AAVE_RS17260	COG3842	ATPase activity
AAVE_RS17265	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AAVE_RS17275	COG3039	Transposase
AAVE_RS17280	COG1283	sodium-dependent phosphate transmembrane transporter activity
AAVE_RS17295	COG0583	DNA-binding transcription factor activity
AAVE_RS17325	COG0697	spore germination
AAVE_RS17420	COG2814	Major facilitator Superfamily
AAVE_RS17465	COG1301	dicarboxylic acid transport
AAVE_RS17470	COG5599	Phosphatase
AAVE_RS17490	COG3038	cytochrome b561
AAVE_RS17500	COG4770	biotin carboxylase activity
AAVE_RS17505	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AAVE_RS17510	COG4336	lyase activity
AAVE_RS17515	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AAVE_RS17520	COG2814	Major facilitator Superfamily
AAVE_RS17540	COG2205	protein histidine kinase activity
AAVE_RS17545	COG1304	FMN binding
AAVE_RS17565	COG5001	Diguanylate cyclase
AAVE_RS17580	COG0831	urea catabolic process
AAVE_RS17590	COG0832	Belongs to the urease beta subunit family
AAVE_RS17595	COG0804	urea catabolic process
AAVE_RS17605	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AAVE_RS17610	COG0830	nickel cation binding
AAVE_RS17615	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AAVE_RS17635	COG2249	NAD(P)H dehydrogenase (quinone) activity
AAVE_RS17640	COG2205	protein histidine kinase activity
AAVE_RS17655	COG2202	Pas domain
AAVE_RS17655	COG2200	EAL domain
AAVE_RS17655	COG2199	diguanylate cyclase activity
AAVE_RS17670	COG4968	Prepilin-type N-terminal cleavage methylation domain
AAVE_RS17675	COG4968	Prepilin-type N-terminal cleavage methylation domain
AAVE_RS17700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AAVE_RS17700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AAVE_RS17745	COG0784	Response regulator, receiver
AAVE_RS17745	COG4191	Histidine kinase
AAVE_RS17750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AAVE_RS17775	COG1595	DNA-templated transcription, initiation
AAVE_RS17790	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AAVE_RS17795	COG4221	oxidoreductase activity
AAVE_RS17810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AAVE_RS17815	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AAVE_RS17835	COG1561	YicC-like family, N-terminal region
AAVE_RS17840	COG0194	GDP metabolic process
AAVE_RS17845	COG1758	RNA polymerase activity
AAVE_RS17850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AAVE_RS17875	COG3693	PFAM glycoside hydrolase, family 10
AAVE_RS17880	COG2197	response regulator
AAVE_RS17890	COG1420	regulation of RNA biosynthetic process
AAVE_RS17895	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AAVE_RS17940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AAVE_RS17945	COG0497	DNA recombination
AAVE_RS17950	COG1660	Displays ATPase and GTPase activities
AAVE_RS17955	COG1194	a g-specific adenine glycosylase
AAVE_RS17965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AAVE_RS17980	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AAVE_RS17990	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AAVE_RS17995	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AAVE_RS18000	COG0193	aminoacyl-tRNA hydrolase activity
AAVE_RS18005	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AAVE_RS18015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AAVE_RS18020	COG0444	Belongs to the ABC transporter superfamily
AAVE_RS18025	COG4608	Belongs to the ABC transporter superfamily
AAVE_RS18035	COG0747	negative chemotaxis
AAVE_RS18060	COG1609	Transcriptional regulator
AAVE_RS18090	COG0302	gtp cyclohydrolase
AAVE_RS18095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AAVE_RS18105	COG0745	RESPONSE REGULATOR receiver
AAVE_RS18110	COG0494	nUDIX hydrolase
AAVE_RS18120	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AAVE_RS18140	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AAVE_RS18155	COG2226	methyltransferase
AAVE_RS18180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AAVE_RS18185	COG1653	transport
AAVE_RS18190	COG1175	transmembrane transport
AAVE_RS18195	COG0395	ABC-type sugar transport system, permease component
AAVE_RS18200	COG3842	ATPase activity
AAVE_RS18210	COG0584	glycerophosphoryl diester phosphodiesterase
AAVE_RS18215	COG1511	domain protein
AAVE_RS18215	COG3264	Mechanosensitive ion channel
AAVE_RS18245	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AAVE_RS18250	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AAVE_RS18260	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AAVE_RS18265	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AAVE_RS18270	COG1253	flavin adenine dinucleotide binding
AAVE_RS18280	COG0442	prolyl-tRNA aminoacylation
AAVE_RS18285	COG0494	nUDIX hydrolase
AAVE_RS18290	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AAVE_RS18295	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AAVE_RS18300	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AAVE_RS18305	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AAVE_RS18310	COG0142	geranyltranstransferase activity
AAVE_RS18320	COG1473	amidohydrolase
AAVE_RS18350	COG0237	dephospho-CoA kinase activity
AAVE_RS18355	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AAVE_RS18360	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AAVE_RS18365	COG0494	nUDIX hydrolase
AAVE_RS18375	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AAVE_RS18380	COG0653	protein targeting
AAVE_RS18385	COG0739	heme binding
AAVE_RS18400	COG2969	positive regulation of protein catabolic process
AAVE_RS18405	COG0625	glutathione transferase activity
AAVE_RS18410	COG2857	Cytochrome c1
AAVE_RS18415	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AAVE_RS18420	COG0723	plastoquinol--plastocyanin reductase activity
AAVE_RS18425	COG1970	mechanosensitive ion channel activity
AAVE_RS18430	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AAVE_RS18435	COG1136	(ABC) transporter
AAVE_RS18440	COG4591	ABC-type transport system involved in lipoprotein release permease component
AAVE_RS18450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AAVE_RS18465	COG0738	Major facilitator superfamily
AAVE_RS18470	COG0613	PHP domain protein
AAVE_RS18475	COG0009	L-threonylcarbamoyladenylate synthase
AAVE_RS18485	COG1994	Peptidase M50
AAVE_RS18490	COG0180	Tryptophanyl-tRNA synthetase
AAVE_RS18495	COG3209	COG3209 Rhs family protein
AAVE_RS18520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AAVE_RS18565	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AAVE_RS18575	COG4774	siderophore transport
AAVE_RS18580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AAVE_RS18635	COG0443	Heat shock 70 kDa protein
AAVE_RS18665	COG0038	chloride channel
AAVE_RS18670	COG3209	COG3209 Rhs family protein
AAVE_RS18680	COG0612	Peptidase, M16
AAVE_RS18685	COG0765	amino acid transport
AAVE_RS18690	COG0765	amino acid transport
AAVE_RS18695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AAVE_RS18710	COG0129	dihydroxy-acid dehydratase activity
AAVE_RS18755	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AAVE_RS18760	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AAVE_RS18765	COG0617	tRNA 3'-terminal CCA addition
AAVE_RS18765	COG0517	IMP dehydrogenase activity
AAVE_RS18765	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AAVE_RS18770	COG1253	flavin adenine dinucleotide binding
AAVE_RS18775	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AAVE_RS18780	COG1047	Peptidyl-prolyl cis-trans
AAVE_RS18785	COG2003	Belongs to the UPF0758 family
AAVE_RS18805	COG1193	negative regulation of DNA recombination
AAVE_RS18830	COG0737	Belongs to the 5'-nucleotidase family
AAVE_RS18860	COG3209	COG3209 Rhs family protein
AAVE_RS18900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AAVE_RS18915	COG0534	Mate efflux family protein
AAVE_RS18920	COG0318	PFAM AMP-dependent synthetase and ligase
AAVE_RS18950	COG2771	luxR family
AAVE_RS18965	COG1802	Transcriptional regulator
AAVE_RS18975	COG0154	amidase activity
AAVE_RS19020	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AAVE_RS19030	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AAVE_RS19035	COG0243	molybdopterin cofactor binding
AAVE_RS19040	COG0840	transmembrane signaling receptor activity
AAVE_RS19045	COG2223	nitrite transmembrane transporter activity
AAVE_RS19050	COG0489	protein tyrosine kinase activity
AAVE_RS19065	COG0028	Belongs to the TPP enzyme family
AAVE_RS19070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AAVE_RS19070	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AAVE_RS19100	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AAVE_RS19110	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AAVE_RS19115	COG0156	8-amino-7-oxononanoate synthase activity
AAVE_RS19120	COG0602	queuosine metabolic process
AAVE_RS19125	COG0720	synthase
AAVE_RS19150	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AAVE_RS19160	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AAVE_RS19165	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AAVE_RS19170	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AAVE_RS19175	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AAVE_RS19185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AAVE_RS19190	COG0588	phosphoglycerate mutase activity
AAVE_RS19195	COG0793	Belongs to the peptidase S41A family
AAVE_RS19200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AAVE_RS19210	COG2197	response regulator
AAVE_RS19245	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AAVE_RS19250	COG0742	ribosomal rna small subunit methyltransferase
AAVE_RS19255	COG0612	Peptidase, M16
AAVE_RS19260	COG0612	Peptidase, M16
AAVE_RS19270	COG0179	Fumarylacetoacetate (FAA) hydrolase
AAVE_RS19290	COG0840	transmembrane signaling receptor activity
AAVE_RS19295	COG4977	sequence-specific DNA binding
AAVE_RS19310	COG0534	Mate efflux family protein
AAVE_RS19340	COG3842	ATPase activity
AAVE_RS19350	COG0583	DNA-binding transcription factor activity
AAVE_RS19355	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AAVE_RS19375	COG1999	signal sequence binding
AAVE_RS19380	COG0109	protoheme IX farnesyltransferase activity
AAVE_RS19385	COG1612	heme a metabolic process
AAVE_RS19430	COG2226	methyltransferase
AAVE_RS19435	COG1040	competence protein
AAVE_RS19440	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AAVE_RS19445	COG0583	DNA-binding transcription factor activity
AAVE_RS19460	COG1192	Involved in chromosome partitioning
AAVE_RS19465	COG1280	lysine exporter protein (LysE YggA)
AAVE_RS19475	COG4774	siderophore transport
AAVE_RS19495	COG3038	cytochrome b561
AAVE_RS19500	COG1846	Transcriptional regulator
AAVE_RS19505	COG0840	transmembrane signaling receptor activity
AAVE_RS19510	COG0477	Major facilitator Superfamily
AAVE_RS19515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AAVE_RS19515	COG2010	Cytochrome c
AAVE_RS19520	COG2080	2 iron, 2 sulfur cluster binding
AAVE_RS19530	COG3473	Maleate cis-trans isomerase
AAVE_RS19535	COG0596	Alpha beta hydrolase
AAVE_RS19540	COG2309	aminopeptidase activity
AAVE_RS19545	COG1335	isochorismatase
AAVE_RS19550	COG2010	Cytochrome c
AAVE_RS19550	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AAVE_RS19570	COG3387	PFAM Glycoside hydrolase 15-related
AAVE_RS19575	COG3181	Tripartite tricarboxylate transporter family receptor
AAVE_RS19585	COG2031	fatty acid transporter
AAVE_RS19605	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AAVE_RS19610	COG0183	Belongs to the thiolase family
AAVE_RS19615	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AAVE_RS19625	COG1414	Transcriptional regulator
AAVE_RS19650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AAVE_RS19715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AAVE_RS19730	COG0346	lactoylglutathione lyase activity
AAVE_RS19755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AAVE_RS19785	COG1132	(ABC) transporter
AAVE_RS19790	COG0189	ligase activity
AAVE_RS19790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AAVE_RS19795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AAVE_RS19795	COG1181	Belongs to the D-alanine--D-alanine ligase family
AAVE_RS19800	COG3045	CreA protein
AAVE_RS19810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AAVE_RS19830	COG3145	DNA-N1-methyladenine dioxygenase activity
AAVE_RS19845	COG0753	catalase activity
AAVE_RS19850	COG0745	RESPONSE REGULATOR receiver
AAVE_RS19865	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AAVE_RS19900	COG0601	transmembrane transport
AAVE_RS19905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AAVE_RS19915	COG0514	ATP-dependent DNA helicase (RecQ)
AAVE_RS19930	COG3209	COG3209 Rhs family protein
AAVE_RS19930	COG3209	COG3209 Rhs family protein
AAVE_RS19950	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AAVE_RS19955	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AAVE_RS19960	COG2080	2 iron, 2 sulfur cluster binding
AAVE_RS20000	COG0737	Belongs to the 5'-nucleotidase family
AAVE_RS20005	COG0583	DNA-binding transcription factor activity
AAVE_RS20010	COG2855	membrane
AAVE_RS20020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AAVE_RS20045	COG2267	carboxylic ester hydrolase activity
AAVE_RS20055	COG3002	Belongs to the UPF0753 family
AAVE_RS20060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AAVE_RS20080	COG2205	protein histidine kinase activity
AAVE_RS20085	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AAVE_RS20110	COG0583	DNA-binding transcription factor activity
AAVE_RS20115	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AAVE_RS20125	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AAVE_RS20130	COG2814	Major facilitator Superfamily
AAVE_RS20135	COG0316	Belongs to the HesB IscA family
AAVE_RS20150	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AAVE_RS20155	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AAVE_RS20160	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AAVE_RS20160	COG0515	serine threonine protein kinase
AAVE_RS20165	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AAVE_RS20170	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AAVE_RS20190	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AAVE_RS20200	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AAVE_RS20210	COG2076	Multidrug Resistance protein
AAVE_RS20240	COG1126	abc transporter atp-binding protein
AAVE_RS20245	COG0765	amino acid transport
AAVE_RS20250	COG0765	amino acid transport
AAVE_RS20255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AAVE_RS20265	COG0583	DNA-binding transcription factor activity
AAVE_RS20270	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AAVE_RS20275	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AAVE_RS20275	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AAVE_RS20280	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AAVE_RS20285	COG5265	(ABC) transporter
AAVE_RS20300	COG3181	Tripartite tricarboxylate transporter family receptor
AAVE_RS20305	COG1024	Enoyl-CoA hydratase
AAVE_RS20315	COG0183	Belongs to the thiolase family
AAVE_RS20325	COG1024	Enoyl-CoA hydratase
AAVE_RS20325	COG1250	3-hydroxyacyl-CoA dehydrogenase
AAVE_RS20335	COG1960	acyl-CoA dehydrogenase activity
AAVE_RS20595	COG1309	transcriptional regulator
AAVE_RS20605	COG0745	RESPONSE REGULATOR receiver
AAVE_RS20610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AAVE_RS20650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AAVE_RS20665	COG1450	Type ii and iii secretion system protein
AAVE_RS20695	COG2165	general secretion pathway protein
AAVE_RS20700	COG4970	Tfp pilus assembly protein FimT
AAVE_RS20705	COG2165	general secretion pathway protein
AAVE_RS20710	COG1459	type II secretion system
AAVE_RS20715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AAVE_RS20755	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AAVE_RS20760	COG1652	LysM domain
AAVE_RS20780	COG0204	Acyl-transferase
AAVE_RS20785	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AAVE_RS20795	COG0751	glycine-tRNA ligase activity
AAVE_RS20800	COG0752	glycyl-tRNA synthetase alpha subunit
AAVE_RS20805	COG3258	Cytochrome c
AAVE_RS20815	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AAVE_RS20830	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AAVE_RS20835	COG4535	Mg2 and Co2 transporter CorC
AAVE_RS20845	COG1522	sequence-specific DNA binding
AAVE_RS20850	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AAVE_RS20870	COG3186	Phenylalanine-4-hydroxylase
AAVE_RS20880	COG0318	PFAM AMP-dependent synthetase and ligase
AAVE_RS20890	COG1129	ABC transporter
AAVE_RS20895	COG1172	Belongs to the binding-protein-dependent transport system permease family
AAVE_RS20905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AAVE_RS20910	COG1869	D-ribose catabolic process
AAVE_RS20920	COG1196	nuclear chromosome segregation
AAVE_RS20920	COG0739	heme binding
AAVE_RS20920	COG0741	lytic transglycosylase activity
AAVE_RS20925	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AAVE_RS20945	COG0617	tRNA 3'-terminal CCA addition
AAVE_RS20960	COG3387	PFAM Glycoside hydrolase 15-related
AAVE_RS21000	COG0456	acetyltransferase
AAVE_RS21015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AAVE_RS21030	COG1028	Short-chain dehydrogenase reductase Sdr
AAVE_RS21040	COG2879	small protein
AAVE_RS21045	COG1966	Carbon starvation protein
AAVE_RS21050	COG2197	response regulator
AAVE_RS21060	COG0037	tRNA processing
AAVE_RS21090	COG2255	four-way junction helicase activity
AAVE_RS21105	COG0632	four-way junction helicase activity
AAVE_RS21110	COG1702	phosphate starvation-inducible protein PhoH
AAVE_RS21115	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AAVE_RS21120	COG1490	D-aminoacyl-tRNA deacylase activity
AAVE_RS21125	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AAVE_RS21130	COG0513	Belongs to the DEAD box helicase family
AAVE_RS21135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AAVE_RS21140	COG3706	GGDEF domain
AAVE_RS21155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AAVE_RS21155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AAVE_RS21165	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AAVE_RS21165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AAVE_RS21185	COG0443	Heat shock 70 kDa protein
AAVE_RS21195	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AAVE_RS21200	COG1131	(ABC) transporter
AAVE_RS21205	COG0842	Transport permease protein
AAVE_RS21210	COG1250	3-hydroxyacyl-CoA dehydrogenase
AAVE_RS21220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AAVE_RS21245	COG0179	Fumarylacetoacetate (FAA) hydrolase
AAVE_RS21250	COG3971	2-oxopent-4-enoate hydratase activity
AAVE_RS21260	COG1846	Transcriptional regulator
AAVE_RS21265	COG1764	response to oxidative stress
AAVE_RS21275	COG0515	serine threonine protein kinase
AAVE_RS21275	COG2815	serine threonine protein kinase
AAVE_RS21320	COG3209	COG3209 Rhs family protein
AAVE_RS21330	COG0326	Molecular chaperone. Has ATPase activity
AAVE_RS21355	COG0840	transmembrane signaling receptor activity
AAVE_RS21375	COG3568	Endonuclease Exonuclease Phosphatase
AAVE_RS21380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AAVE_RS21385	COG0392	lysyltransferase activity
AAVE_RS21390	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AAVE_RS21400	COG0840	transmembrane signaling receptor activity
AAVE_RS21435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AAVE_RS21440	COG1024	Enoyl-CoA hydratase
AAVE_RS21445	COG1960	acyl-CoA dehydrogenase activity
AAVE_RS21450	COG1960	acyl-CoA dehydrogenase activity
AAVE_RS21455	COG1250	3-hydroxyacyl-CoA dehydrogenase
AAVE_RS21455	COG1024	Enoyl-CoA hydratase
AAVE_RS21460	COG0583	DNA-binding transcription factor activity
AAVE_RS21465	COG0501	Belongs to the peptidase M48B family
AAVE_RS21480	COG0418	dihydroorotase activity
AAVE_RS21485	COG2205	protein histidine kinase activity
AAVE_RS21490	COG0745	RESPONSE REGULATOR receiver
AAVE_RS21505	COG1136	(ABC) transporter
AAVE_RS21505	COG0577	efflux transmembrane transporter activity
AAVE_RS21535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AAVE_RS21575	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AAVE_RS21590	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AAVE_RS21625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AAVE_RS21640	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AAVE_RS21645	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AAVE_RS21650	COG0318	PFAM AMP-dependent synthetase and ligase
AAVE_RS21675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AAVE_RS21680	COG2205	protein histidine kinase activity
AAVE_RS21680	COG0784	Response regulator, receiver
AAVE_RS21680	COG2198	Histidine kinase
AAVE_RS21685	COG3012	SEC-C Motif Domain Protein
AAVE_RS21700	COG1960	acyl-CoA dehydrogenase activity
AAVE_RS21715	COG0183	Belongs to the thiolase family
AAVE_RS21720	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AAVE_RS21725	COG0288	reversible hydration of carbon dioxide
AAVE_RS21730	COG1960	acyl-CoA dehydrogenase activity
AAVE_RS21735	COG0789	Transcriptional regulator
AAVE_RS21765	COG0488	(ABC) transporter
AAVE_RS21770	COG2201	protein-glutamate methylesterase activity
AAVE_RS21775	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AAVE_RS21780	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AAVE_RS21785	COG0835	chemotaxis
AAVE_RS21790	COG0643	Histidine kinase
AAVE_RS21790	COG2198	Histidine kinase
AAVE_RS21795	COG0745	RESPONSE REGULATOR receiver
AAVE_RS21805	COG3851	Histidine kinase
AAVE_RS21810	COG2197	response regulator
AAVE_RS21820	COG1987	bacterial-type flagellum assembly
AAVE_RS21835	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AAVE_RS21845	COG1580	Controls the rotational direction of flagella during chemotaxis
AAVE_RS21875	COG1766	The M ring may be actively involved in energy transduction
AAVE_RS21880	COG1677	Flagellar hook-basal body complex protein FliE
AAVE_RS21915	COG4106	trans-aconitate 2-methyltransferase activity
AAVE_RS21925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AAVE_RS21930	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AAVE_RS21935	COG0438	transferase activity, transferring glycosyl groups
AAVE_RS21935	COG1216	Glycosyl transferase, family 2
AAVE_RS21940	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AAVE_RS21945	COG1360	Flagellar Motor Protein
AAVE_RS21950	COG0745	RESPONSE REGULATOR receiver
AAVE_RS21955	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AAVE_RS21960	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AAVE_RS22000	COG1815	bacterial-type flagellum-dependent cell motility
AAVE_RS22005	COG1558	bacterial-type flagellum-dependent cell motility
AAVE_RS22010	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AAVE_RS22020	COG4787	bacterial-type flagellum-dependent cell motility
AAVE_RS22030	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AAVE_RS22040	COG1706	bacterial-type flagellum-dependent cell motility
AAVE_RS22045	COG3951	Flagellar rod assembly protein muramidase FlgJ
AAVE_RS22045	COG1705	Flagellar rod assembly protein muramidase FlgJ
AAVE_RS22055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AAVE_RS22070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AAVE_RS22080	COG0697	spore germination
AAVE_RS22085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AAVE_RS22090	COG0625	glutathione transferase activity
AAVE_RS22095	COG0384	phenazine biosynthesis protein PhzF
AAVE_RS22130	COG0840	transmembrane signaling receptor activity
AAVE_RS22175	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AAVE_RS22205	COG0861	Integral membrane protein TerC family
AAVE_RS22210	COG0583	DNA-binding transcription factor activity
AAVE_RS22225	COG3119	arylsulfatase activity
AAVE_RS22240	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AAVE_RS22245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AAVE_RS22265	COG0210	DNA helicase
AAVE_RS22285	COG0343	queuine tRNA-ribosyltransferase activity
AAVE_RS22305	COG1028	Short-chain dehydrogenase reductase Sdr
AAVE_RS22335	COG1522	sequence-specific DNA binding
AAVE_RS22340	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AAVE_RS22350	COG0840	transmembrane signaling receptor activity
AAVE_RS22390	COG3181	Tripartite tricarboxylate transporter family receptor
AAVE_RS22400	COG2072	flavoprotein involved in K transport
AAVE_RS22410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AAVE_RS22430	COG2365	Tyrosine phosphatase family
AAVE_RS22435	COG1028	Short-chain dehydrogenase reductase Sdr
AAVE_RS22445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AAVE_RS22450	COG1116	anion transmembrane transporter activity
AAVE_RS22465	COG3046	protein related to deoxyribodipyrimidine photolyase
AAVE_RS22470	COG3550	peptidyl-serine autophosphorylation
AAVE_RS22485	COG2032	superoxide dismutase activity
AAVE_RS22500	COG2204	response regulator
AAVE_RS22505	COG5000	phosphorelay sensor kinase activity
AAVE_RS22515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AAVE_RS22515	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AAVE_RS22525	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AAVE_RS22530	COG0085	RNA polymerase activity
AAVE_RS22535	COG0222	ribosome binding
AAVE_RS22540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AAVE_RS22545	COG0081	regulation of translation
AAVE_RS22550	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AAVE_RS22560	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AAVE_RS22570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AAVE_RS22615	COG0189	ligase activity
AAVE_RS22620	COG3135	benzoate transporter
AAVE_RS22625	COG3158	transport of potassium into the cell
AAVE_RS22635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AAVE_RS22640	COG0569	domain protein
AAVE_RS22645	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AAVE_RS22665	COG0495	leucyl-tRNA aminoacylation
AAVE_RS22675	COG5001	Diguanylate cyclase
AAVE_RS22675	COG3300	MHYT domain
AAVE_RS22690	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AAVE_RS22695	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AAVE_RS22700	COG0735	belongs to the Fur family
AAVE_RS22705	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AAVE_RS22715	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AAVE_RS22720	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AAVE_RS22730	COG3118	belongs to the thioredoxin family
AAVE_RS22735	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AAVE_RS22740	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AAVE_RS22745	COG0009	L-threonylcarbamoyladenylate synthase
AAVE_RS22770	COG1214	PFAM Peptidase M22, glycoprotease
AAVE_RS22785	COG0598	Magnesium transport protein CorA
AAVE_RS22795	COG0318	PFAM AMP-dependent synthetase and ligase
AAVE_RS22830	COG0469	pyruvate kinase activity
AAVE_RS22835	COG0006	proline dipeptidase activity
AAVE_RS22840	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AAVE_RS22845	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AAVE_RS22850	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AAVE_RS22870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AAVE_RS22880	COG0583	DNA-binding transcription factor activity
AAVE_RS22915	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AAVE_RS22975	COG0668	transmembrane transport
AAVE_RS22985	COG2194	sulfuric ester hydrolase activity
AAVE_RS22990	COG1028	Short-chain dehydrogenase reductase Sdr
AAVE_RS23005	COG2764	glyoxalase bleomycin resistance protein dioxygenase
AAVE_RS23055	COG1714	RDD family
AAVE_RS23080	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AAVE_RS23080	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AAVE_RS23110	COG0583	DNA-binding transcription factor activity
AAVE_RS23120	COG0642	Histidine kinase
AAVE_RS23135	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AAVE_RS23140	COG2137	regulation of response to DNA damage stimulus
AAVE_RS23150	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AAVE_RS23155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AAVE_RS23160	COG1862	Preprotein translocase
AAVE_RS23170	COG1522	sequence-specific DNA binding
AAVE_RS23180	COG2814	Major facilitator Superfamily
AAVE_RS23200	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AAVE_RS23230	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AAVE_RS23235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AAVE_RS23250	COG1309	transcriptional regulator
AAVE_RS23260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AAVE_RS23285	COG0625	glutathione transferase activity
AAVE_RS23310	COG0861	Integral membrane protein TerC family
AAVE_RS23320	COG1950	PFAM Membrane protein of
AAVE_RS23325	COG4783	chaperone-mediated protein folding
AAVE_RS23330	COG0315	cyclic pyranopterin monophosphate synthase activity
AAVE_RS23340	COG1716	ATPase activity
AAVE_RS23345	COG0631	protein serine/threonine phosphatase activity
AAVE_RS23350	COG0861	Integral membrane protein TerC family
AAVE_RS23355	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AAVE_RS23360	COG0045	succinate-CoA ligase (ADP-forming) activity
AAVE_RS23365	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AAVE_RS23370	COG0758	DNA mediated transformation
AAVE_RS23380	COG0242	peptide deformylase activity
AAVE_RS23390	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AAVE_RS23405	COG0126	phosphoglycerate kinase activity
AAVE_RS23415	COG0697	spore germination
AAVE_RS23420	COG0284	orotidine-5'-phosphate decarboxylase activity
AAVE_RS23425	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AAVE_RS23455	COG0840	transmembrane signaling receptor activity
AAVE_RS23485	COG2814	Major facilitator Superfamily
AAVE_RS23495	COG0629	single-stranded DNA binding
AAVE_RS23515	COG0640	Transcriptional regulator
AAVE_RS23530	COG1620	l-lactate permease
AAVE_RS23535	COG0482	sulfurtransferase activity
AAVE_RS23540	COG0494	nUDIX hydrolase
AAVE_RS23570	COG0307	riboflavin synthase, alpha
AAVE_RS23595	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AAVE_RS23600	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AAVE_RS23660	COG1802	Transcriptional regulator
AAVE_RS23710	COG0281	malic enzyme
AAVE_RS23710	COG0280	phosphate acetyltransferase
AAVE_RS23725	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AAVE_RS23730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AAVE_RS23735	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AAVE_RS23745	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AAVE_RS23760	COG1196	nuclear chromosome segregation
AAVE_RS23765	COG2814	Major facilitator Superfamily
AAVE_RS23775	COG2207	Transcriptional regulator
AAVE_RS23780	COG1113	amino acid transport
AAVE_RS23785	COG4303	Ethanolamine ammonia lyase large subunit
AAVE_RS23790	COG4302	ethanolamine ammonia-lyase activity
AAVE_RS23800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AAVE_RS23805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AAVE_RS23810	COG2119	membrane
AAVE_RS23815	COG0724	RNA recognition motif
AAVE_RS23820	COG0724	RNA recognition motif
AAVE_RS23825	COG0300	oxidoreductase activity
AAVE_RS23835	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AAVE_RS23850	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AAVE_RS23870	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AAVE_RS23880	COG0706	membrane insertase activity
AAVE_RS23885	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AAVE_RS23890	COG0594	ribonuclease P activity
AAVE_RS23895	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AAVE_RS24070	COG3916	Acyl-homoserine-lactone synthase
AAVE_RS24110	COG0076	glutamate decarboxylase activity