locus-tag	class	description
LKW27_RS00010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LKW27_RS00015	COG0791	NLP P60 protein
LKW27_RS00020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LKW27_RS00035	COG2176	DNA-directed DNA polymerase activity
LKW27_RS00050	COG1199	ATP-dependent helicase activity
LKW27_RS00070	COG1764	response to oxidative stress
LKW27_RS00120	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LKW27_RS00125	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LKW27_RS00130	COG0594	ribonuclease P activity
LKW27_RS00135	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LKW27_RS00140	COG0706	membrane insertase activity
LKW27_RS00150	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LKW27_RS00170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LKW27_RS00185	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LKW27_RS00195	COG0300	oxidoreductase activity
LKW27_RS00200	COG0724	RNA recognition motif
LKW27_RS00205	COG0724	RNA recognition motif
LKW27_RS00210	COG2119	membrane
LKW27_RS00215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LKW27_RS00220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LKW27_RS00230	COG4302	ethanolamine ammonia-lyase activity
LKW27_RS00235	COG4303	Ethanolamine ammonia lyase large subunit
LKW27_RS00240	COG1113	amino acid transport
LKW27_RS00245	COG2207	Transcriptional regulator
LKW27_RS00255	COG2814	Major facilitator Superfamily
LKW27_RS00260	COG1196	nuclear chromosome segregation
LKW27_RS00275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LKW27_RS00285	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LKW27_RS00290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LKW27_RS00295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LKW27_RS00310	COG0281	malic enzyme
LKW27_RS00310	COG0280	phosphate acetyltransferase
LKW27_RS00360	COG1802	Transcriptional regulator
LKW27_RS00420	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LKW27_RS00425	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LKW27_RS00450	COG0307	riboflavin synthase, alpha
LKW27_RS00480	COG0494	nUDIX hydrolase
LKW27_RS00485	COG0482	sulfurtransferase activity
LKW27_RS00490	COG1620	l-lactate permease
LKW27_RS00515	COG0640	Transcriptional regulator
LKW27_RS00540	COG0629	single-stranded DNA binding
LKW27_RS00550	COG2814	Major facilitator Superfamily
LKW27_RS00560	COG0529	Catalyzes the synthesis of activated sulfate
LKW27_RS00590	COG0840	transmembrane signaling receptor activity
LKW27_RS00620	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LKW27_RS00625	COG0284	orotidine-5'-phosphate decarboxylase activity
LKW27_RS00630	COG0697	spore germination
LKW27_RS00640	COG0126	phosphoglycerate kinase activity
LKW27_RS00655	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LKW27_RS00665	COG0242	peptide deformylase activity
LKW27_RS00675	COG0758	DNA mediated transformation
LKW27_RS00680	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LKW27_RS00685	COG0045	succinate-CoA ligase (ADP-forming) activity
LKW27_RS00690	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LKW27_RS00695	COG0861	Integral membrane protein TerC family
LKW27_RS00700	COG0631	protein serine/threonine phosphatase activity
LKW27_RS00705	COG1716	ATPase activity
LKW27_RS00715	COG3307	-O-antigen
LKW27_RS00725	COG0315	cyclic pyranopterin monophosphate synthase activity
LKW27_RS00730	COG4783	chaperone-mediated protein folding
LKW27_RS00735	COG1950	PFAM Membrane protein of
LKW27_RS00745	COG0861	Integral membrane protein TerC family
LKW27_RS00770	COG0625	glutathione transferase activity
LKW27_RS00795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LKW27_RS00805	COG1309	transcriptional regulator
LKW27_RS00820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LKW27_RS00825	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LKW27_RS00855	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LKW27_RS00875	COG2814	Major facilitator Superfamily
LKW27_RS00885	COG1522	sequence-specific DNA binding
LKW27_RS00895	COG1862	Preprotein translocase
LKW27_RS00900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LKW27_RS00905	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LKW27_RS00915	COG2137	regulation of response to DNA damage stimulus
LKW27_RS00920	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LKW27_RS00935	COG0642	Histidine kinase
LKW27_RS00945	COG0583	DNA-binding transcription factor activity
LKW27_RS00975	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LKW27_RS00975	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LKW27_RS01010	COG1714	RDD family
LKW27_RS01065	COG2764	glyoxalase bleomycin resistance protein dioxygenase
LKW27_RS01080	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_RS01085	COG2194	sulfuric ester hydrolase activity
LKW27_RS01095	COG0668	transmembrane transport
LKW27_RS01150	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LKW27_RS01185	COG0583	DNA-binding transcription factor activity
LKW27_RS01195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LKW27_RS01215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LKW27_RS01220	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LKW27_RS01225	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LKW27_RS01230	COG0006	proline dipeptidase activity
LKW27_RS01235	COG0469	pyruvate kinase activity
LKW27_RS01270	COG0318	PFAM AMP-dependent synthetase and ligase
LKW27_RS01280	COG0598	Magnesium transport protein CorA
LKW27_RS01295	COG1214	PFAM Peptidase M22, glycoprotease
LKW27_RS01320	COG0009	L-threonylcarbamoyladenylate synthase
LKW27_RS01325	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LKW27_RS01330	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LKW27_RS01335	COG3118	belongs to the thioredoxin family
LKW27_RS01345	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LKW27_RS01350	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LKW27_RS01360	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LKW27_RS01365	COG0735	belongs to the Fur family
LKW27_RS01370	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LKW27_RS01375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LKW27_RS01390	COG3300	MHYT domain
LKW27_RS01390	COG5001	Diguanylate cyclase
LKW27_RS01400	COG0495	leucyl-tRNA aminoacylation
LKW27_RS01420	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LKW27_RS01425	COG0569	domain protein
LKW27_RS01440	COG3158	transport of potassium into the cell
LKW27_RS01445	COG3135	benzoate transporter
LKW27_RS01450	COG0189	ligase activity
LKW27_RS01495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LKW27_RS01505	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LKW27_RS01515	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LKW27_RS01520	COG0081	regulation of translation
LKW27_RS01525	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LKW27_RS01530	COG0222	ribosome binding
LKW27_RS01535	COG0085	RNA polymerase activity
LKW27_RS01540	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LKW27_RS01550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LKW27_RS01550	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LKW27_RS01560	COG5000	phosphorelay sensor kinase activity
LKW27_RS01565	COG2204	response regulator
LKW27_RS01580	COG2032	superoxide dismutase activity
LKW27_RS01605	COG3046	protein related to deoxyribodipyrimidine photolyase
LKW27_RS01620	COG1116	anion transmembrane transporter activity
LKW27_RS01625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LKW27_RS01635	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_RS01640	COG2365	Tyrosine phosphatase family
LKW27_RS01660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LKW27_RS01675	COG2072	flavoprotein involved in K transport
LKW27_RS01680	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_RS01720	COG0840	transmembrane signaling receptor activity
LKW27_RS01730	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LKW27_RS01735	COG1522	sequence-specific DNA binding
LKW27_RS01760	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_RS01790	COG0343	queuine tRNA-ribosyltransferase activity
LKW27_RS01810	COG0210	DNA helicase
LKW27_RS01830	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LKW27_RS01840	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LKW27_RS01855	COG3119	arylsulfatase activity
LKW27_RS01880	COG0583	DNA-binding transcription factor activity
LKW27_RS01885	COG0861	Integral membrane protein TerC family
LKW27_RS01920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LKW27_RS01965	COG0840	transmembrane signaling receptor activity
LKW27_RS01995	COG0384	phenazine biosynthesis protein PhzF
LKW27_RS02000	COG0625	glutathione transferase activity
LKW27_RS02005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LKW27_RS02010	COG0697	spore germination
LKW27_RS02020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LKW27_RS02035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LKW27_RS02045	COG1705	Flagellar rod assembly protein muramidase FlgJ
LKW27_RS02045	COG3951	Flagellar rod assembly protein muramidase FlgJ
LKW27_RS02050	COG1706	bacterial-type flagellum-dependent cell motility
LKW27_RS02060	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LKW27_RS02070	COG4787	bacterial-type flagellum-dependent cell motility
LKW27_RS02080	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LKW27_RS02085	COG1558	bacterial-type flagellum-dependent cell motility
LKW27_RS02090	COG1815	bacterial-type flagellum-dependent cell motility
LKW27_RS02130	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LKW27_RS02135	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LKW27_RS02140	COG0745	RESPONSE REGULATOR receiver
LKW27_RS02145	COG1360	Flagellar Motor Protein
LKW27_RS02150	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LKW27_RS02155	COG0438	transferase activity, transferring glycosyl groups
LKW27_RS02155	COG1216	Glycosyl transferase, family 2
LKW27_RS02160	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LKW27_RS02165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LKW27_RS02175	COG4106	trans-aconitate 2-methyltransferase activity
LKW27_RS02210	COG1677	Flagellar hook-basal body complex protein FliE
LKW27_RS02215	COG1766	The M ring may be actively involved in energy transduction
LKW27_RS02245	COG1580	Controls the rotational direction of flagella during chemotaxis
LKW27_RS02255	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LKW27_RS02270	COG1987	bacterial-type flagellum assembly
LKW27_RS02280	COG2197	response regulator
LKW27_RS02285	COG3851	Histidine kinase
LKW27_RS02295	COG0745	RESPONSE REGULATOR receiver
LKW27_RS02300	COG0643	Histidine kinase
LKW27_RS02300	COG2198	Histidine kinase
LKW27_RS02305	COG0835	chemotaxis
LKW27_RS02310	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LKW27_RS02315	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LKW27_RS02320	COG2201	protein-glutamate methylesterase activity
LKW27_RS02325	COG0488	(ABC) transporter
LKW27_RS02355	COG0789	Transcriptional regulator
LKW27_RS02365	COG1960	acyl-CoA dehydrogenase activity
LKW27_RS02370	COG0288	reversible hydration of carbon dioxide
LKW27_RS02375	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LKW27_RS02380	COG0183	Belongs to the thiolase family
LKW27_RS02395	COG1960	acyl-CoA dehydrogenase activity
LKW27_RS02410	COG3012	SEC-C Motif Domain Protein
LKW27_RS02415	COG2205	protein histidine kinase activity
LKW27_RS02415	COG2198	Histidine kinase
LKW27_RS02415	COG0784	Response regulator, receiver
LKW27_RS02420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LKW27_RS02440	COG0318	PFAM AMP-dependent synthetase and ligase
LKW27_RS02445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LKW27_RS02450	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LKW27_RS02465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LKW27_RS02500	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LKW27_RS02515	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LKW27_RS02565	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LKW27_RS02595	COG0577	efflux transmembrane transporter activity
LKW27_RS02595	COG1136	(ABC) transporter
LKW27_RS02610	COG0745	RESPONSE REGULATOR receiver
LKW27_RS02615	COG2205	protein histidine kinase activity
LKW27_RS02620	COG0418	dihydroorotase activity
LKW27_RS02635	COG0501	Belongs to the peptidase M48B family
LKW27_RS02640	COG0583	DNA-binding transcription factor activity
LKW27_RS02645	COG1024	Enoyl-CoA hydratase
LKW27_RS02645	COG1250	3-hydroxyacyl-CoA dehydrogenase
LKW27_RS02650	COG1960	acyl-CoA dehydrogenase activity
LKW27_RS02655	COG1960	acyl-CoA dehydrogenase activity
LKW27_RS02660	COG1024	Enoyl-CoA hydratase
LKW27_RS02665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LKW27_RS02700	COG0840	transmembrane signaling receptor activity
LKW27_RS02710	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
LKW27_RS02715	COG0392	lysyltransferase activity
LKW27_RS02720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LKW27_RS02725	COG3568	Endonuclease Exonuclease Phosphatase
LKW27_RS02745	COG0840	transmembrane signaling receptor activity
LKW27_RS02775	COG0326	Molecular chaperone. Has ATPase activity
LKW27_RS02810	COG3209	COG3209 Rhs family protein
LKW27_RS02855	COG0515	serine threonine protein kinase
LKW27_RS02855	COG2815	serine threonine protein kinase
LKW27_RS02870	COG1764	response to oxidative stress
LKW27_RS02875	COG1846	Transcriptional regulator
LKW27_RS02885	COG3971	2-oxopent-4-enoate hydratase activity
LKW27_RS02890	COG0179	Fumarylacetoacetate (FAA) hydrolase
LKW27_RS02910	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LKW27_RS02920	COG1250	3-hydroxyacyl-CoA dehydrogenase
LKW27_RS02925	COG0842	Transport permease protein
LKW27_RS02930	COG1131	(ABC) transporter
LKW27_RS02935	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LKW27_RS02945	COG0443	Heat shock 70 kDa protein
LKW27_RS02965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LKW27_RS02965	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LKW27_RS02975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LKW27_RS02975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LKW27_RS02990	COG3706	GGDEF domain
LKW27_RS02995	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LKW27_RS03000	COG0513	Belongs to the DEAD box helicase family
LKW27_RS03005	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LKW27_RS03010	COG1490	D-aminoacyl-tRNA deacylase activity
LKW27_RS03015	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LKW27_RS03035	COG1702	phosphate starvation-inducible protein PhoH
LKW27_RS03040	COG0632	four-way junction helicase activity
LKW27_RS03055	COG2255	four-way junction helicase activity
LKW27_RS03085	COG0037	tRNA processing
LKW27_RS03095	COG2197	response regulator
LKW27_RS03100	COG1966	Carbon starvation protein
LKW27_RS03105	COG2879	small protein
LKW27_RS03115	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_RS03130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LKW27_RS03150	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LKW27_RS03155	COG3387	PFAM Glycoside hydrolase 15-related
LKW27_RS03170	COG0617	tRNA 3'-terminal CCA addition
LKW27_RS03195	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LKW27_RS03200	COG0739	heme binding
LKW27_RS03200	COG0741	lytic transglycosylase activity
LKW27_RS03200	COG1196	nuclear chromosome segregation
LKW27_RS03210	COG1869	D-ribose catabolic process
LKW27_RS03215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LKW27_RS03225	COG1172	Belongs to the binding-protein-dependent transport system permease family
LKW27_RS03230	COG1129	ABC transporter
LKW27_RS03240	COG0318	PFAM AMP-dependent synthetase and ligase
LKW27_RS03255	COG3186	Phenylalanine-4-hydroxylase
LKW27_RS03275	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LKW27_RS03280	COG1522	sequence-specific DNA binding
LKW27_RS03295	COG4535	Mg2 and Co2 transporter CorC
LKW27_RS03300	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LKW27_RS03315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LKW27_RS03325	COG3258	Cytochrome c
LKW27_RS03330	COG0752	glycyl-tRNA synthetase alpha subunit
LKW27_RS03335	COG0751	glycine-tRNA ligase activity
LKW27_RS03345	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LKW27_RS03350	COG0204	Acyl-transferase
LKW27_RS03370	COG1652	LysM domain
LKW27_RS03375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LKW27_RS03415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LKW27_RS03420	COG1459	type II secretion system
LKW27_RS03425	COG2165	general secretion pathway protein
LKW27_RS03430	COG4970	Tfp pilus assembly protein FimT
LKW27_RS03435	COG2165	general secretion pathway protein
LKW27_RS03465	COG1450	Type ii and iii secretion system protein
LKW27_RS03480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LKW27_RS03520	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LKW27_RS03525	COG0745	RESPONSE REGULATOR receiver
LKW27_RS03535	COG1309	transcriptional regulator
LKW27_RS03545	COG1960	acyl-CoA dehydrogenase activity
LKW27_RS03565	COG0183	Belongs to the thiolase family
LKW27_RS03575	COG1024	Enoyl-CoA hydratase
LKW27_RS03580	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_RS03595	COG5265	(ABC) transporter
LKW27_RS03600	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LKW27_RS03605	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LKW27_RS03605	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LKW27_RS03610	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LKW27_RS03615	COG0583	DNA-binding transcription factor activity
LKW27_RS03625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LKW27_RS03630	COG0765	amino acid transport
LKW27_RS03635	COG0765	amino acid transport
LKW27_RS03640	COG1126	abc transporter atp-binding protein
LKW27_RS03670	COG2076	Multidrug Resistance protein
LKW27_RS03680	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LKW27_RS03690	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LKW27_RS03710	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LKW27_RS03715	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LKW27_RS03725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LKW27_RS03730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LKW27_RS03745	COG0316	Belongs to the HesB IscA family
LKW27_RS03750	COG2814	Major facilitator Superfamily
LKW27_RS03755	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LKW27_RS03765	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LKW27_RS03770	COG0583	DNA-binding transcription factor activity
LKW27_RS03795	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LKW27_RS03840	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LKW27_RS03845	COG3002	Belongs to the UPF0753 family
LKW27_RS03855	COG2267	carboxylic ester hydrolase activity
LKW27_RS03880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LKW27_RS03890	COG2855	membrane
LKW27_RS03895	COG0583	DNA-binding transcription factor activity
LKW27_RS03900	COG0737	Belongs to the 5'-nucleotidase family
LKW27_RS03940	COG2080	2 iron, 2 sulfur cluster binding
LKW27_RS03945	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LKW27_RS03950	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LKW27_RS03970	COG3209	COG3209 Rhs family protein
LKW27_RS03970	COG3209	COG3209 Rhs family protein
LKW27_RS03990	COG0514	ATP-dependent DNA helicase (RecQ)
LKW27_RS04000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LKW27_RS04005	COG0601	transmembrane transport
LKW27_RS04040	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LKW27_RS04050	COG0784	Response regulator, receiver
LKW27_RS04050	COG5002	protein histidine kinase activity
LKW27_RS04055	COG0745	RESPONSE REGULATOR receiver
LKW27_RS04060	COG0753	catalase activity
LKW27_RS04075	COG3145	DNA-N1-methyladenine dioxygenase activity
LKW27_RS04090	COG3045	CreA protein
LKW27_RS04095	COG1181	Belongs to the D-alanine--D-alanine ligase family
LKW27_RS04095	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LKW27_RS04100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LKW27_RS04100	COG0189	ligase activity
LKW27_RS04105	COG1132	(ABC) transporter
LKW27_RS04135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LKW27_RS04165	COG0346	lactoylglutathione lyase activity
LKW27_RS04180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LKW27_RS04250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LKW27_RS04280	COG1414	Transcriptional regulator
LKW27_RS04290	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LKW27_RS04295	COG0183	Belongs to the thiolase family
LKW27_RS04300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LKW27_RS04320	COG2031	fatty acid transporter
LKW27_RS04330	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_RS04355	COG2010	Cytochrome c
LKW27_RS04355	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LKW27_RS04360	COG1335	isochorismatase
LKW27_RS04365	COG2309	aminopeptidase activity
LKW27_RS04370	COG0596	Alpha beta hydrolase
LKW27_RS04375	COG3473	Maleate cis-trans isomerase
LKW27_RS04385	COG2080	2 iron, 2 sulfur cluster binding
LKW27_RS04390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LKW27_RS04390	COG2010	Cytochrome c
LKW27_RS04395	COG0477	Major facilitator Superfamily
LKW27_RS04400	COG0840	transmembrane signaling receptor activity
LKW27_RS04405	COG1846	Transcriptional regulator
LKW27_RS04410	COG3038	cytochrome b561
LKW27_RS04430	COG4774	siderophore transport
LKW27_RS04440	COG1280	lysine exporter protein (LysE YggA)
LKW27_RS04445	COG1192	Involved in chromosome partitioning
LKW27_RS04460	COG0583	DNA-binding transcription factor activity
LKW27_RS04465	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LKW27_RS04470	COG1040	competence protein
LKW27_RS04475	COG2226	methyltransferase
LKW27_RS04525	COG1612	heme a metabolic process
LKW27_RS04530	COG0109	protoheme IX farnesyltransferase activity
LKW27_RS04535	COG1999	signal sequence binding
LKW27_RS04555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LKW27_RS04565	COG0583	DNA-binding transcription factor activity
LKW27_RS04575	COG3842	ATPase activity
LKW27_RS04610	COG0534	Mate efflux family protein
LKW27_RS04625	COG4977	sequence-specific DNA binding
LKW27_RS04630	COG0840	transmembrane signaling receptor activity
LKW27_RS04655	COG0179	Fumarylacetoacetate (FAA) hydrolase
LKW27_RS04665	COG0612	Peptidase, M16
LKW27_RS04670	COG0612	Peptidase, M16
LKW27_RS04675	COG0742	ribosomal rna small subunit methyltransferase
LKW27_RS04680	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LKW27_RS04705	COG5487	UPF0391 membrane protein
LKW27_RS04715	COG2197	response regulator
LKW27_RS04725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LKW27_RS04730	COG0793	Belongs to the peptidase S41A family
LKW27_RS04735	COG0588	phosphoglycerate mutase activity
LKW27_RS04740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LKW27_RS04750	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LKW27_RS04755	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LKW27_RS04760	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LKW27_RS04765	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LKW27_RS04775	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LKW27_RS04800	COG0720	synthase
LKW27_RS04805	COG0602	queuosine metabolic process
LKW27_RS04810	COG0156	8-amino-7-oxononanoate synthase activity
LKW27_RS04815	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LKW27_RS04825	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LKW27_RS04855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LKW27_RS04855	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LKW27_RS04860	COG0028	Belongs to the TPP enzyme family
LKW27_RS04875	COG0489	protein tyrosine kinase activity
LKW27_RS04880	COG2223	nitrite transmembrane transporter activity
LKW27_RS04885	COG0840	transmembrane signaling receptor activity
LKW27_RS04890	COG0243	molybdopterin cofactor binding
LKW27_RS04895	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LKW27_RS04905	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LKW27_RS04950	COG0154	amidase activity
LKW27_RS04960	COG1802	Transcriptional regulator
LKW27_RS04970	COG3916	Acyl-homoserine-lactone synthase
LKW27_RS04975	COG2771	luxR family
LKW27_RS05005	COG0318	PFAM AMP-dependent synthetase and ligase
LKW27_RS05010	COG0534	Mate efflux family protein
LKW27_RS05025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LKW27_RS05095	COG0737	Belongs to the 5'-nucleotidase family
LKW27_RS05120	COG1193	negative regulation of DNA recombination
LKW27_RS05140	COG2003	Belongs to the UPF0758 family
LKW27_RS05145	COG1047	Peptidyl-prolyl cis-trans
LKW27_RS05150	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LKW27_RS05155	COG1253	flavin adenine dinucleotide binding
LKW27_RS05160	COG0517	IMP dehydrogenase activity
LKW27_RS05160	COG0617	tRNA 3'-terminal CCA addition
LKW27_RS05160	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LKW27_RS05165	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LKW27_RS05170	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LKW27_RS05220	COG0129	dihydroxy-acid dehydratase activity
LKW27_RS05235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LKW27_RS05240	COG0765	amino acid transport
LKW27_RS05245	COG0765	amino acid transport
LKW27_RS05250	COG0612	Peptidase, M16
LKW27_RS05260	COG3209	COG3209 Rhs family protein
LKW27_RS05295	COG0038	chloride channel
LKW27_RS05340	COG0443	Heat shock 70 kDa protein
LKW27_RS05395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LKW27_RS05400	COG4774	siderophore transport
LKW27_RS05410	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LKW27_RS05485	COG3209	COG3209 Rhs family protein
LKW27_RS05490	COG0180	Tryptophanyl-tRNA synthetase
LKW27_RS05495	COG1994	Peptidase M50
LKW27_RS05505	COG0009	L-threonylcarbamoyladenylate synthase
LKW27_RS05510	COG0613	PHP domain protein
LKW27_RS05515	COG0738	Major facilitator superfamily
LKW27_RS05530	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LKW27_RS05540	COG4591	ABC-type transport system involved in lipoprotein release permease component
LKW27_RS05545	COG1136	(ABC) transporter
LKW27_RS05550	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LKW27_RS05555	COG1970	mechanosensitive ion channel activity
LKW27_RS05560	COG0723	plastoquinol--plastocyanin reductase activity
LKW27_RS05565	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LKW27_RS05570	COG2857	Cytochrome c1
LKW27_RS05575	COG0625	glutathione transferase activity
LKW27_RS05580	COG2969	positive regulation of protein catabolic process
LKW27_RS05595	COG0739	heme binding
LKW27_RS05600	COG0653	protein targeting
LKW27_RS05605	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LKW27_RS05615	COG0494	nUDIX hydrolase
LKW27_RS05620	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LKW27_RS05625	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LKW27_RS05630	COG0237	dephospho-CoA kinase activity
LKW27_RS05650	COG0583	DNA-binding transcription factor activity
LKW27_RS05660	COG1473	amidohydrolase
LKW27_RS05670	COG0142	geranyltranstransferase activity
LKW27_RS05675	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LKW27_RS05680	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LKW27_RS05685	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LKW27_RS05690	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LKW27_RS05695	COG0494	nUDIX hydrolase
LKW27_RS05700	COG0442	prolyl-tRNA aminoacylation
LKW27_RS05710	COG1253	flavin adenine dinucleotide binding
LKW27_RS05715	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LKW27_RS05720	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LKW27_RS05730	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LKW27_RS05735	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LKW27_RS05765	COG1511	domain protein
LKW27_RS05765	COG3264	Mechanosensitive ion channel
LKW27_RS05770	COG0584	glycerophosphoryl diester phosphodiesterase
LKW27_RS05780	COG3842	ATPase activity
LKW27_RS05785	COG0395	ABC-type sugar transport system, permease component
LKW27_RS05790	COG1175	transmembrane transport
LKW27_RS05795	COG1653	transport
LKW27_RS05800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LKW27_RS05825	COG2226	methyltransferase
LKW27_RS05840	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LKW27_RS05860	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LKW27_RS05870	COG0494	nUDIX hydrolase
LKW27_RS05875	COG0745	RESPONSE REGULATOR receiver
LKW27_RS05885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LKW27_RS05890	COG0302	gtp cyclohydrolase
LKW27_RS05920	COG1609	Transcriptional regulator
LKW27_RS05950	COG0747	negative chemotaxis
LKW27_RS05960	COG4608	Belongs to the ABC transporter superfamily
LKW27_RS05965	COG0444	Belongs to the ABC transporter superfamily
LKW27_RS05970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LKW27_RS05980	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LKW27_RS05985	COG0193	aminoacyl-tRNA hydrolase activity
LKW27_RS05990	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LKW27_RS05995	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LKW27_RS06005	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LKW27_RS06020	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LKW27_RS06030	COG1194	a g-specific adenine glycosylase
LKW27_RS06035	COG1660	Displays ATPase and GTPase activities
LKW27_RS06040	COG0497	DNA recombination
LKW27_RS06045	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LKW27_RS06110	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LKW27_RS06115	COG1420	regulation of RNA biosynthetic process
LKW27_RS06125	COG2197	response regulator
LKW27_RS06130	COG3693	PFAM glycoside hydrolase, family 10
LKW27_RS06160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LKW27_RS06165	COG1758	RNA polymerase activity
LKW27_RS06170	COG0194	GDP metabolic process
LKW27_RS06175	COG1561	YicC-like family, N-terminal region
LKW27_RS06195	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LKW27_RS06200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LKW27_RS06215	COG4221	oxidoreductase activity
LKW27_RS06220	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LKW27_RS06235	COG1595	DNA-templated transcription, initiation
LKW27_RS06260	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LKW27_RS06265	COG0784	Response regulator, receiver
LKW27_RS06265	COG4191	Histidine kinase
LKW27_RS06310	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LKW27_RS06310	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LKW27_RS06335	COG4968	Prepilin-type N-terminal cleavage methylation domain
LKW27_RS06340	COG4968	Prepilin-type N-terminal cleavage methylation domain
LKW27_RS06365	COG1063	alcohol dehydrogenase
LKW27_RS06375	COG2205	protein histidine kinase activity
LKW27_RS06380	COG2249	NAD(P)H dehydrogenase (quinone) activity
LKW27_RS06395	COG0464	growth
LKW27_RS06410	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LKW27_RS06415	COG0830	nickel cation binding
LKW27_RS06420	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LKW27_RS06430	COG0804	urea catabolic process
LKW27_RS06435	COG0832	Belongs to the urease beta subunit family
LKW27_RS06445	COG0831	urea catabolic process
LKW27_RS06460	COG5001	Diguanylate cyclase
LKW27_RS06480	COG1304	FMN binding
LKW27_RS06485	COG2205	protein histidine kinase activity
LKW27_RS06505	COG2814	Major facilitator Superfamily
LKW27_RS06510	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LKW27_RS06515	COG4336	lyase activity
LKW27_RS06520	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LKW27_RS06525	COG4770	biotin carboxylase activity
LKW27_RS06535	COG3038	cytochrome b561
LKW27_RS06555	COG5599	Phosphatase
LKW27_RS06560	COG1301	dicarboxylic acid transport
LKW27_RS06605	COG2814	Major facilitator Superfamily
LKW27_RS06705	COG0697	spore germination
LKW27_RS06740	COG0583	DNA-binding transcription factor activity
LKW27_RS06755	COG1283	sodium-dependent phosphate transmembrane transporter activity
LKW27_RS06765	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LKW27_RS06770	COG3842	ATPase activity
LKW27_RS06780	COG1177	transmembrane transport
LKW27_RS06785	COG4149	molybdate abc transporter
LKW27_RS06795	COG1609	Transcriptional regulator
LKW27_RS06810	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LKW27_RS06820	COG0196	riboflavin kinase activity
LKW27_RS06830	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LKW27_RS06840	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LKW27_RS06850	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LKW27_RS06870	COG1960	acyl-CoA dehydrogenase activity
LKW27_RS06875	COG3132	Protein of unknown function, DUF480
LKW27_RS06880	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LKW27_RS06895	COG3866	Pectate lyase
LKW27_RS06900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LKW27_RS06900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LKW27_RS06915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LKW27_RS06920	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LKW27_RS06925	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LKW27_RS06930	COG0492	ferredoxin-NADP+ reductase activity
LKW27_RS06935	COG1674	ftsk spoiiie
LKW27_RS06940	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LKW27_RS06950	COG1573	uracil-dna glycosylase
LKW27_RS06955	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LKW27_RS06960	COG0840	transmembrane signaling receptor activity
LKW27_RS06965	COG0559	Belongs to the binding-protein-dependent transport system permease family
LKW27_RS06985	COG2885	chlorophyll binding
LKW27_RS06985	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LKW27_RS06990	COG1392	Phosphate transport regulator
LKW27_RS06995	COG0306	phosphate transporter
LKW27_RS07010	COG0228	four-way junction DNA binding
LKW27_RS07015	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LKW27_RS07020	COG0336	Belongs to the RNA methyltransferase TrmD family
LKW27_RS07025	COG0335	large ribosomal subunit rRNA binding
LKW27_RS07035	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LKW27_RS07040	COG1162	GTPase activity
LKW27_RS07045	COG2154	pterin-4-alpha-carbinolamine dehydratase
LKW27_RS07055	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LKW27_RS07060	COG0513	Belongs to the DEAD box helicase family
LKW27_RS07065	COG3447	MASE1 domain protein
LKW27_RS07065	COG5001	Diguanylate cyclase
LKW27_RS07065	COG5002	protein histidine kinase activity
LKW27_RS07070	COG2814	Major facilitator Superfamily
LKW27_RS07085	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LKW27_RS07090	COG5002	protein histidine kinase activity
LKW27_RS07095	COG2204	response regulator
LKW27_RS07145	COG0516	GMP reductase activity
LKW27_RS07230	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LKW27_RS07270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LKW27_RS07275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LKW27_RS07305	COG0412	Dienelactone hydrolase
LKW27_RS07315	COG0165	Argininosuccinate lyase
LKW27_RS07325	COG3275	phosphorelay sensor kinase activity
LKW27_RS07330	COG0165	Argininosuccinate lyase
LKW27_RS07365	COG0840	transmembrane signaling receptor activity
LKW27_RS07370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LKW27_RS07380	COG1304	FMN binding
LKW27_RS07385	COG0840	transmembrane signaling receptor activity
LKW27_RS07405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LKW27_RS07430	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LKW27_RS07435	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LKW27_RS07445	COG0617	tRNA 3'-terminal CCA addition
LKW27_RS07485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LKW27_RS07490	COG1960	acyl-CoA dehydrogenase activity
LKW27_RS07495	COG0583	DNA-binding transcription factor activity
LKW27_RS07540	COG2816	NAD+ diphosphatase activity
LKW27_RS07545	COG0425	Belongs to the sulfur carrier protein TusA family
LKW27_RS07555	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LKW27_RS07560	COG0525	valine-tRNA ligase activity
LKW27_RS07565	COG0501	Belongs to the peptidase M48B family
LKW27_RS07575	COG0488	(ABC) transporter
LKW27_RS07595	COG0181	hydroxymethylbilane synthase activity
LKW27_RS07600	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LKW27_RS07605	COG1289	transmembrane transporter activity
LKW27_RS07610	COG0628	permease
LKW27_RS07665	COG1722	exodeoxyribonuclease VII activity
LKW27_RS07670	COG0142	geranyltranstransferase activity
LKW27_RS07675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LKW27_RS07680	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LKW27_RS07700	COG0668	transmembrane transport
LKW27_RS07705	COG0366	Alpha amylase catalytic
LKW27_RS07710	COG0366	Alpha amylase catalytic
LKW27_RS07715	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LKW27_RS07720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LKW27_RS07725	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LKW27_RS07745	COG3585	molybdate ion transport
LKW27_RS07745	COG2005	Transcriptional regulator
LKW27_RS07755	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LKW27_RS07765	COG1280	lysine exporter protein (LysE YggA)
LKW27_RS07770	COG3279	Response regulator of the LytR AlgR family
LKW27_RS07775	COG3275	phosphorelay sensor kinase activity
LKW27_RS07805	COG1968	undecaprenyl-diphosphatase activity
LKW27_RS07810	COG5001	Diguanylate cyclase
LKW27_RS07810	COG3447	MASE1 domain protein
LKW27_RS07810	COG5002	protein histidine kinase activity
LKW27_RS07835	COG3209	COG3209 Rhs family protein
LKW27_RS07850	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LKW27_RS07855	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LKW27_RS07910	COG0784	Response regulator, receiver
LKW27_RS07910	COG2205	protein histidine kinase activity
LKW27_RS07910	COG5002	protein histidine kinase activity
LKW27_RS07915	COG3437	response regulator, receiver
LKW27_RS07925	COG1132	(ABC) transporter
LKW27_RS07945	COG0483	inositol monophosphate 1-phosphatase activity
LKW27_RS07960	COG4555	ABC transporter
LKW27_RS07965	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LKW27_RS07975	COG1045	serine acetyltransferase
LKW27_RS07980	COG0521	Mo-molybdopterin cofactor biosynthetic process
LKW27_RS07985	COG3028	Belongs to the UPF0307 family
LKW27_RS07990	COG0312	modulator of DNA gyrase
LKW27_RS08005	COG2721	sulfolactate sulfo-lyase activity
LKW27_RS08020	COG0477	Major facilitator Superfamily
LKW27_RS08025	COG1752	Esterase of the alpha-beta hydrolase superfamily
LKW27_RS08030	COG0473	3-isopropylmalate dehydrogenase activity
LKW27_RS08035	COG0583	DNA-binding transcription factor activity
LKW27_RS08045	COG0625	glutathione transferase activity
LKW27_RS08050	COG1610	YqeY-like protein
LKW27_RS08055	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LKW27_RS08075	COG0640	Transcriptional regulator
LKW27_RS08080	COG2081	HI0933 family
LKW27_RS08095	COG0288	reversible hydration of carbon dioxide
LKW27_RS08100	COG1607	acyl-coa hydrolase
LKW27_RS08105	COG5297	Belongs to the glycosyl hydrolase family 6
LKW27_RS08105	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LKW27_RS08115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LKW27_RS08120	COG0243	molybdopterin cofactor binding
LKW27_RS08130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LKW27_RS08135	COG0840	transmembrane signaling receptor activity
LKW27_RS08150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LKW27_RS08160	COG0840	transmembrane signaling receptor activity
LKW27_RS08165	COG0517	IMP dehydrogenase activity
LKW27_RS08165	COG0516	GMP reductase activity
LKW27_RS08185	COG0643	Histidine kinase
LKW27_RS08185	COG2198	Histidine kinase
LKW27_RS08190	COG0840	transmembrane signaling receptor activity
LKW27_RS08200	COG0745	RESPONSE REGULATOR receiver
LKW27_RS08215	COG2223	nitrite transmembrane transporter activity
LKW27_RS08220	COG3959	Transketolase, thiamine diphosphate binding domain
LKW27_RS08225	COG3958	Transketolase
LKW27_RS08230	COG0194	GDP metabolic process
LKW27_RS08245	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LKW27_RS08260	COG0626	cystathionine gamma-synthase activity
LKW27_RS08270	COG0724	RNA recognition motif
LKW27_RS08285	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LKW27_RS08290	COG1116	anion transmembrane transporter activity
LKW27_RS08295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LKW27_RS08300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LKW27_RS08320	COG0683	leucine binding
LKW27_RS08325	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LKW27_RS08340	COG0683	leucine binding
LKW27_RS08370	COG2951	lytic endotransglycosylase activity
LKW27_RS08385	COG0714	Associated with various cellular activities
LKW27_RS08390	COG0123	including yeast histone deacetylase and acetoin utilization protein
LKW27_RS08395	COG1024	Enoyl-CoA hydratase
LKW27_RS08410	COG3264	Mechanosensitive ion channel
LKW27_RS08410	COG1511	domain protein
LKW27_RS08425	COG1960	acyl-CoA dehydrogenase activity
LKW27_RS08470	COG1473	amidohydrolase
LKW27_RS08475	COG1522	sequence-specific DNA binding
LKW27_RS08485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LKW27_RS08505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LKW27_RS08515	COG0601	transmembrane transport
LKW27_RS08520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LKW27_RS08530	COG0473	3-isopropylmalate dehydrogenase activity
LKW27_RS08540	COG2194	sulfuric ester hydrolase activity
LKW27_RS08545	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LKW27_RS08555	COG4977	sequence-specific DNA binding
LKW27_RS08560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LKW27_RS08575	COG0372	Belongs to the citrate synthase family
LKW27_RS08580	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LKW27_RS08585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LKW27_RS08590	COG1053	succinate dehydrogenase
LKW27_RS08605	COG2188	Transcriptional regulator
LKW27_RS08610	COG0039	L-malate dehydrogenase activity
LKW27_RS08615	COG4106	trans-aconitate 2-methyltransferase activity
LKW27_RS08630	COG1049	propionate catabolic process, 2-methylcitrate cycle
LKW27_RS08635	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
LKW27_RS08650	COG0826	peptidase U32
LKW27_RS08655	COG0583	DNA-binding transcription factor activity
LKW27_RS08680	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LKW27_RS08685	COG1845	cytochrome c oxidase, subunit III
LKW27_RS08690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LKW27_RS08695	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LKW27_RS08700	COG0477	Major facilitator Superfamily
LKW27_RS08720	COG0824	Thioesterase
LKW27_RS08725	COG0436	Aminotransferase
LKW27_RS08730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LKW27_RS08735	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LKW27_RS08760	COG2205	protein histidine kinase activity
LKW27_RS08760	COG2202	Pas domain
LKW27_RS08770	COG0745	RESPONSE REGULATOR receiver
LKW27_RS08775	COG2201	protein-glutamate methylesterase activity
LKW27_RS08795	COG1289	transmembrane transporter activity
LKW27_RS08800	COG4948	Mandelate Racemase Muconate Lactonizing
LKW27_RS08805	COG0800	Aldolase
LKW27_RS08810	COG3734	2-keto-3-deoxy-galactonokinase
LKW27_RS08825	COG1172	Belongs to the binding-protein-dependent transport system permease family
LKW27_RS08830	COG1172	Belongs to the binding-protein-dependent transport system permease family
LKW27_RS08840	COG4214	carbohydrate transport
LKW27_RS08850	COG4213	ABC transporter substrate-binding protein
LKW27_RS08855	COG1879	ABC-type sugar transport system periplasmic component
LKW27_RS08875	COG3386	PFAM SMP-30 Gluconolaconase
LKW27_RS08885	COG2918	glutathione biosynthetic process
LKW27_RS08910	COG5002	protein histidine kinase activity
LKW27_RS08925	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LKW27_RS08945	COG2814	Major facilitator Superfamily
LKW27_RS08960	COG1285	pathogenesis
LKW27_RS08965	COG0564	pseudouridine synthase activity
LKW27_RS08995	COG0840	transmembrane signaling receptor activity
LKW27_RS09025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LKW27_RS09065	COG1309	transcriptional regulator
LKW27_RS09080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LKW27_RS09090	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LKW27_RS09105	COG3384	dioxygenase
LKW27_RS09125	COG1522	sequence-specific DNA binding
LKW27_RS09180	COG0215	cysteine-tRNA ligase activity
LKW27_RS09195	COG0037	tRNA processing
LKW27_RS09200	COG0527	aspartate kinase activity
LKW27_RS09265	COG3209	COG3209 Rhs family protein
LKW27_RS09310	COG0791	NLP P60 protein
LKW27_RS09315	COG2133	pyrroloquinoline quinone binding
LKW27_RS09365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LKW27_RS09365	COG1042	CoA-binding domain protein
LKW27_RS09365	COG0045	succinate-CoA ligase (ADP-forming) activity
LKW27_RS09385	COG1309	transcriptional regulator
LKW27_RS09390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LKW27_RS09400	COG1136	(ABC) transporter
LKW27_RS09425	COG4771	TonB-dependent receptor
LKW27_RS09430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LKW27_RS09445	COG0259	pyridoxamine-phosphate oxidase activity
LKW27_RS09470	COG1609	Transcriptional regulator
LKW27_RS09475	COG3265	gluconokinase activity
LKW27_RS09480	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LKW27_RS09485	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LKW27_RS09490	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LKW27_RS09500	COG0800	Aldolase
LKW27_RS09510	COG0346	lactoylglutathione lyase activity
LKW27_RS09515	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_RS09560	COG0583	DNA-binding transcription factor activity
LKW27_RS09565	COG0431	NADPH-dependent FMN reductase
LKW27_RS09575	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LKW27_RS09605	COG0564	pseudouridine synthase activity
LKW27_RS09610	COG2982	Protein involved in outer membrane biogenesis
LKW27_RS09615	COG0587	DNA-directed DNA polymerase activity
LKW27_RS09630	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LKW27_RS09655	COG1012	belongs to the aldehyde dehydrogenase family
LKW27_RS09680	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LKW27_RS09685	COG0746	molybdenum cofactor guanylyltransferase activity
LKW27_RS09695	COG0303	'Molybdopterin
LKW27_RS09710	COG0328	RNA-DNA hybrid ribonuclease activity
LKW27_RS09715	COG2226	methyltransferase
LKW27_RS09720	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LKW27_RS09780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LKW27_RS09785	COG0741	lytic transglycosylase activity
LKW27_RS09785	COG1388	LysM domain
LKW27_RS09805	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LKW27_RS09810	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LKW27_RS09815	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LKW27_RS09830	COG2081	HI0933 family
LKW27_RS09835	COG1074	ATP-dependent DNA helicase activity
LKW27_RS09850	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LKW27_RS09855	COG0419	ATPase involved in DNA repair
LKW27_RS09860	COG0420	3'-5' exonuclease activity
LKW27_RS09865	COG0254	rRNA binding
LKW27_RS09875	COG0534	Mate efflux family protein
LKW27_RS09890	COG0704	Plays a role in the regulation of phosphate uptake
LKW27_RS09895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LKW27_RS09900	COG0581	inorganic phosphate transmembrane transporter activity
LKW27_RS09905	COG0573	inorganic phosphate transmembrane transporter activity
LKW27_RS09910	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LKW27_RS09915	COG0248	Ppx GppA phosphatase
LKW27_RS09945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LKW27_RS09955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LKW27_RS09960	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LKW27_RS09965	COG1534	Rna-binding protein
LKW27_RS09980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LKW27_RS09985	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LKW27_RS09990	COG0505	Belongs to the CarA family
LKW27_RS10000	COG1113	amino acid transport
LKW27_RS10025	COG1960	acyl-CoA dehydrogenase activity
LKW27_RS10040	COG2032	superoxide dismutase activity
LKW27_RS10045	COG4772	TonB-dependent receptor
LKW27_RS10060	COG2721	sulfolactate sulfo-lyase activity
LKW27_RS10075	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LKW27_RS10085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LKW27_RS10095	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_RS10100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LKW27_RS10140	COG0789	Transcriptional regulator
LKW27_RS10145	COG2814	Major facilitator Superfamily
LKW27_RS10160	COG1942	4-Oxalocrotonate Tautomerase
LKW27_RS10165	COG0625	glutathione transferase activity
LKW27_RS10195	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LKW27_RS10200	COG1570	exodeoxyribonuclease VII activity
LKW27_RS10205	COG0811	peptide transport
LKW27_RS10210	COG0848	biopolymer transport protein
LKW27_RS10215	COG1663	tetraacyldisaccharide 4'-kinase activity
LKW27_RS10220	COG2835	tetraacyldisaccharide 4'-kinase activity
LKW27_RS10225	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LKW27_RS10230	COG0563	adenylate kinase activity
LKW27_RS10240	COG0252	asparaginase activity
LKW27_RS10245	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LKW27_RS10255	COG1643	Atp-dependent helicase
LKW27_RS10265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LKW27_RS10270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LKW27_RS10270	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LKW27_RS10295	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LKW27_RS10300	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LKW27_RS10305	COG4208	sulfate ABC transporter
LKW27_RS10310	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LKW27_RS10315	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LKW27_RS10335	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LKW27_RS10355	COG2011	ABC-type metal ion transport system permease component
LKW27_RS10360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LKW27_RS10370	COG2814	Major facilitator Superfamily
LKW27_RS10375	COG0583	DNA-binding transcription factor activity
LKW27_RS10380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LKW27_RS10395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LKW27_RS10410	COG5002	protein histidine kinase activity
LKW27_RS10450	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LKW27_RS10470	COG4770	biotin carboxylase activity
LKW27_RS10480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LKW27_RS10485	COG1703	isobutyryl-CoA mutase activity
LKW27_RS10495	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LKW27_RS10495	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LKW27_RS10500	COG1802	Transcriptional regulator
LKW27_RS10565	COG0840	transmembrane signaling receptor activity
LKW27_RS10580	COG3039	Transposase
LKW27_RS10595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LKW27_RS10615	COG2878	Part of a membrane complex involved in electron transport
LKW27_RS10620	COG0840	transmembrane signaling receptor activity
LKW27_RS10630	COG2171	N-acyltransferase activity
LKW27_RS10640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LKW27_RS10645	COG2890	protein-(glutamine-N5) methyltransferase activity
LKW27_RS10650	COG0488	(ABC) transporter
LKW27_RS10655	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_RS10660	COG0183	Belongs to the thiolase family
LKW27_RS10665	COG3243	poly(R)-hydroxyalkanoic acid synthase
LKW27_RS10695	COG0515	serine threonine protein kinase
LKW27_RS10705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LKW27_RS10710	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LKW27_RS10735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LKW27_RS10740	COG0508	dehydrogenase complex catalyzes the overall conversion of
LKW27_RS10745	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LKW27_RS10755	COG4566	intracellular signal transduction
LKW27_RS10760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LKW27_RS10775	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LKW27_RS10780	COG0167	dihydroorotate dehydrogenase activity
LKW27_RS10800	COG0579	oxidoreductase
LKW27_RS10825	COG0633	Ferredoxin
LKW27_RS10830	COG0443	Heat shock 70 kDa protein
LKW27_RS10835	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LKW27_RS10845	COG0822	iron-sulfur transferase activity
LKW27_RS10850	COG1104	cysteine desulfurase activity
LKW27_RS10855	COG1959	2 iron, 2 sulfur cluster binding
LKW27_RS10860	COG0556	nucleotide-excision repair
LKW27_RS10870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LKW27_RS10885	COG0840	transmembrane signaling receptor activity
LKW27_RS10900	COG1739	Uncharacterized protein family UPF0029
LKW27_RS10920	COG0154	amidase activity
LKW27_RS10925	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_RS10930	COG3048	D-serine ammonia-lyase activity
LKW27_RS10955	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LKW27_RS11025	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LKW27_RS11035	COG1196	nuclear chromosome segregation
LKW27_RS11045	COG1742	UPF0060 membrane protein
LKW27_RS11055	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LKW27_RS11060	COG1132	(ABC) transporter
LKW27_RS11085	COG0789	Transcriptional regulator
LKW27_RS11090	COG0776	regulation of translation
LKW27_RS11095	COG0072	phenylalanine-tRNA ligase activity
LKW27_RS11095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LKW27_RS11100	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LKW27_RS11105	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LKW27_RS11110	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LKW27_RS11115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LKW27_RS11120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LKW27_RS11125	COG2224	Isocitrate lyase
LKW27_RS11140	COG1522	sequence-specific DNA binding
LKW27_RS11145	COG0697	spore germination
LKW27_RS11155	COG1840	ABC-type Fe3 transport system, periplasmic component
LKW27_RS11175	COG2153	protein acetylation
LKW27_RS11180	COG2130	NADP-dependent
LKW27_RS11200	COG1960	acyl-CoA dehydrogenase activity
LKW27_RS11205	COG2050	protein possibly involved in aromatic compounds catabolism
LKW27_RS11210	COG0183	Belongs to the thiolase family
LKW27_RS11215	COG1250	3-hydroxyacyl-CoA dehydrogenase
LKW27_RS11215	COG1024	Enoyl-CoA hydratase
LKW27_RS11230	COG3706	GGDEF domain
LKW27_RS11255	COG0411	ABC transporter
LKW27_RS11265	COG0559	Belongs to the binding-protein-dependent transport system permease family
LKW27_RS11275	COG0318	PFAM AMP-dependent synthetase and ligase
LKW27_RS11280	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LKW27_RS11285	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LKW27_RS11290	COG2917	probably involved in intracellular septation
LKW27_RS11300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LKW27_RS11320	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LKW27_RS11325	COG0688	phosphatidylethanolamine metabolic process
LKW27_RS11340	COG5006	permease, DMT superfamily
LKW27_RS11355	COG1228	amidohydrolase
LKW27_RS11370	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LKW27_RS11375	COG2986	histidine ammonia-lyase
LKW27_RS11380	COG2188	Transcriptional regulator
LKW27_RS11390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LKW27_RS11400	COG1366	Belongs to the anti-sigma-factor antagonist family
LKW27_RS11405	COG1366	Belongs to the anti-sigma-factor antagonist family
LKW27_RS11410	COG2172	sigma factor antagonist activity
LKW27_RS11420	COG2205	protein histidine kinase activity
LKW27_RS11425	COG2205	protein histidine kinase activity
LKW27_RS11430	COG0784	Response regulator, receiver
LKW27_RS11430	COG4191	Histidine kinase
LKW27_RS11450	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LKW27_RS11470	COG0297	glycogen (starch) synthase activity
LKW27_RS11475	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_RS11480	COG0557	exoribonuclease II activity
LKW27_RS11505	COG0741	lytic transglycosylase activity
LKW27_RS11510	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LKW27_RS11515	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LKW27_RS11525	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LKW27_RS11530	COG0517	IMP dehydrogenase activity
LKW27_RS11530	COG1125	glycine betaine transport
LKW27_RS11545	COG1011	Hydrolase
LKW27_RS11550	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LKW27_RS11555	COG5002	protein histidine kinase activity
LKW27_RS11605	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_RS11615	COG0642	Histidine kinase
LKW27_RS11630	COG0667	Aldo Keto reductase
LKW27_RS11635	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LKW27_RS11640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LKW27_RS11645	COG4181	ATPase activity
LKW27_RS11685	COG1054	Belongs to the UPF0176 family
LKW27_RS11690	COG1741	Belongs to the pirin family
LKW27_RS11700	COG1741	Belongs to the pirin family
LKW27_RS11705	COG0583	DNA-binding transcription factor activity
LKW27_RS11710	COG0493	'glutamate synthase
LKW27_RS11710	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
LKW27_RS11715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LKW27_RS11720	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LKW27_RS11730	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LKW27_RS11755	COG0583	DNA-binding transcription factor activity
LKW27_RS11765	COG1116	anion transmembrane transporter activity
LKW27_RS11770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LKW27_RS11780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LKW27_RS11790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LKW27_RS11800	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LKW27_RS11805	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LKW27_RS11805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LKW27_RS11820	COG0730	response to heat
LKW27_RS11835	COG0175	sulfate reduction
LKW27_RS11840	COG0529	Catalyzes the synthesis of activated sulfate
LKW27_RS11840	COG2895	sulfate adenylyltransferase (ATP) activity
LKW27_RS11845	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LKW27_RS11850	COG0492	ferredoxin-NADP+ reductase activity
LKW27_RS11900	COG0351	phosphomethylpyrimidine kinase
LKW27_RS11915	COG2022	thiamine diphosphate biosynthetic process
LKW27_RS11930	COG1250	3-hydroxyacyl-CoA dehydrogenase
LKW27_RS11935	COG1024	Enoyl-CoA hydratase
LKW27_RS11950	COG1960	acyl-CoA dehydrogenase activity
LKW27_RS11965	COG1619	proteins homologs of microcin C7 resistance protein MccF
LKW27_RS11990	COG0826	peptidase U32
LKW27_RS12005	COG0823	Involved in the tonB-independent uptake of proteins
LKW27_RS12005	COG1506	peptidase
LKW27_RS12005	COG4946	Tricorn protease homolog
LKW27_RS12015	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LKW27_RS12020	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LKW27_RS12035	COG3047	cAMP biosynthetic process
LKW27_RS12040	COG2354	Protein conserved in bacteria
LKW27_RS12045	COG3300	MHYT domain
LKW27_RS12045	COG5001	Diguanylate cyclase
LKW27_RS12060	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LKW27_RS12060	COG0047	phosphoribosylformylglycinamidine synthase activity
LKW27_RS12065	COG0024	Methionine aminopeptidase
LKW27_RS12070	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LKW27_RS12075	COG0242	peptide deformylase activity
LKW27_RS12080	COG2832	Protein of unknown function (DUF454)
LKW27_RS12095	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LKW27_RS12100	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LKW27_RS12105	COG1414	Transcriptional regulator
LKW27_RS12115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LKW27_RS12120	COG1183	phosphatidylcholine synthase activity
LKW27_RS12125	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LKW27_RS12130	COG0440	acetolactate synthase activity
LKW27_RS12135	COG0028	Belongs to the TPP enzyme family
LKW27_RS12145	COG1595	DNA-templated transcription, initiation
LKW27_RS12165	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LKW27_RS12175	COG0347	Belongs to the P(II) protein family
LKW27_RS12190	COG0583	DNA-binding transcription factor activity
LKW27_RS12200	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_RS12205	COG0835	chemotaxis
LKW27_RS12230	COG1252	NADH dehydrogenase
LKW27_RS12240	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LKW27_RS12275	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_RS12295	COG4120	Belongs to the binding-protein-dependent transport system permease family
LKW27_RS12310	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LKW27_RS12315	COG0509	glycine decarboxylation via glycine cleavage system
LKW27_RS12320	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LKW27_RS12320	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LKW27_RS12325	COG0545	Peptidyl-prolyl cis-trans isomerase
LKW27_RS12335	COG0564	pseudouridine synthase activity
LKW27_RS12340	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_RS12360	COG0589	response to stress
LKW27_RS12400	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LKW27_RS12420	COG0583	DNA-binding transcription factor activity
LKW27_RS12425	COG0436	Aminotransferase
LKW27_RS12460	COG0683	leucine binding
LKW27_RS12470	COG1960	acyl-CoA dehydrogenase activity
LKW27_RS12475	COG1024	Enoyl-CoA hydratase
LKW27_RS12485	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_RS12500	COG0596	Alpha beta hydrolase
LKW27_RS12505	COG2205	protein histidine kinase activity
LKW27_RS12515	COG3593	DNA synthesis involved in DNA repair
LKW27_RS12525	COG0210	DNA helicase
LKW27_RS12560	COG1530	ribonuclease E activity
LKW27_RS12565	COG0424	maF-like protein
LKW27_RS12575	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LKW27_RS12580	COG0799	negative regulation of ribosome biogenesis
LKW27_RS12585	COG0408	coproporphyrinogen oxidase activity
LKW27_RS12590	COG0151	Belongs to the GarS family
LKW27_RS12595	COG0217	transcriptional regulatory protein
LKW27_RS12600	COG0433	COG0433 Predicted ATPase
LKW27_RS12620	COG0277	FAD linked oxidase domain protein
LKW27_RS12625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LKW27_RS12650	COG0625	glutathione transferase activity
LKW27_RS12665	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LKW27_RS12680	COG0402	S-adenosylhomocysteine deaminase activity
LKW27_RS12715	COG0484	heat shock protein binding
LKW27_RS12720	COG1012	belongs to the aldehyde dehydrogenase family
LKW27_RS12740	COG3284	Transcriptional regulator
LKW27_RS12750	COG2925	Exonuclease
LKW27_RS12755	COG2951	lytic endotransglycosylase activity
LKW27_RS12760	COG0542	response to heat
LKW27_RS12765	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LKW27_RS12780	COG1199	ATP-dependent helicase activity
LKW27_RS12795	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LKW27_RS12800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LKW27_RS12805	COG0508	dehydrogenase complex catalyzes the overall conversion of
LKW27_RS12810	COG0567	Dehydrogenase, E1 component
LKW27_RS12815	COG0628	permease
LKW27_RS12820	COG5002	protein histidine kinase activity
LKW27_RS12820	COG5001	Diguanylate cyclase
LKW27_RS12820	COG3447	MASE1 domain protein
LKW27_RS12825	COG4172	Belongs to the ABC transporter superfamily
LKW27_RS12830	COG4239	(ABC) transporter, permease
LKW27_RS12835	COG4174	ABC transporter (Permease)
LKW27_RS12840	COG4166	transmembrane transport
LKW27_RS12850	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LKW27_RS12970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LKW27_RS12985	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LKW27_RS12990	COG1605	Chorismate mutase
LKW27_RS12990	COG0077	Prephenate dehydratase
LKW27_RS12995	COG0287	Prephenate dehydrogenase
LKW27_RS13000	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LKW27_RS13010	COG0776	regulation of translation
LKW27_RS13020	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LKW27_RS13025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LKW27_RS13025	COG2111	Na H antiporter
LKW27_RS13030	COG1006	Multisubunit Na H antiporter MnhC subunit
LKW27_RS13035	COG0651	ATP synthesis coupled electron transport
LKW27_RS13045	COG2212	antiporter activity
LKW27_RS13080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LKW27_RS13105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LKW27_RS13110	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LKW27_RS13115	COG0405	Gamma-glutamyltransferase
LKW27_RS13155	COG3193	protein, possibly involved in utilization of glycolate and propanediol
LKW27_RS13160	COG0670	Belongs to the BI1 family
LKW27_RS13170	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LKW27_RS13185	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LKW27_RS13185	COG0506	proline dehydrogenase activity
LKW27_RS13185	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LKW27_RS13195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LKW27_RS13205	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LKW27_RS13210	COG4774	siderophore transport
LKW27_RS13245	COG0494	nUDIX hydrolase
LKW27_RS13250	COG1278	Cold shock
LKW27_RS13265	COG0492	ferredoxin-NADP+ reductase activity
LKW27_RS13270	COG2226	methyltransferase
LKW27_RS13315	COG3209	COG3209 Rhs family protein
LKW27_RS13335	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_RS13380	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LKW27_RS13420	COG0582	viral genome integration into host DNA
LKW27_RS13505	COG0582	viral genome integration into host DNA
LKW27_RS13510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LKW27_RS13510	COG0519	Catalyzes the synthesis of GMP from XMP
LKW27_RS13535	COG2914	Belongs to the UPF0125 (RnfH) family
LKW27_RS13545	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LKW27_RS13565	COG1024	Enoyl-CoA hydratase
LKW27_RS13570	COG1253	flavin adenine dinucleotide binding
LKW27_RS13580	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LKW27_RS13585	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LKW27_RS13590	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LKW27_RS13595	COG0195	Participates in both transcription termination and antitermination
LKW27_RS13600	COG0779	Required for maturation of 30S ribosomal subunits
LKW27_RS13610	COG2010	Cytochrome c
LKW27_RS13610	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LKW27_RS13675	COG2423	ornithine cyclodeaminase activity
LKW27_RS13695	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LKW27_RS13705	COG2885	chlorophyll binding
LKW27_RS13710	COG0823	Involved in the tonB-independent uptake of proteins
LKW27_RS13715	COG1132	(ABC) transporter
LKW27_RS13725	COG0084	hydrolase, TatD family'
LKW27_RS13740	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LKW27_RS13745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LKW27_RS13760	COG0657	acetylesterase activity
LKW27_RS13770	COG1454	alcohol dehydrogenase
LKW27_RS13785	COG2183	response to ionizing radiation
LKW27_RS13810	COG2814	Major facilitator Superfamily
LKW27_RS13815	COG2814	Major facilitator Superfamily
LKW27_RS13855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LKW27_RS13870	COG1286	toxin biosynthetic process
LKW27_RS13880	COG0285	dihydrofolate synthase activity
LKW27_RS13885	COG1393	Belongs to the ArsC family
LKW27_RS13895	COG3123	guanosine phosphorylase activity
LKW27_RS13900	COG0137	argininosuccinate synthase activity
LKW27_RS13910	COG1666	GTP binding
LKW27_RS13915	COG3577	Aspartyl protease
LKW27_RS13925	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LKW27_RS13930	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LKW27_RS13935	COG0667	Aldo Keto reductase
LKW27_RS13940	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LKW27_RS13950	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LKW27_RS13960	COG0308	aminopeptidase N
LKW27_RS13965	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LKW27_RS13975	COG0583	DNA-binding transcription factor activity
LKW27_RS13980	COG1960	acyl-CoA dehydrogenase activity
LKW27_RS13985	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_RS13990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LKW27_RS13995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LKW27_RS14000	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LKW27_RS14005	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LKW27_RS14010	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LKW27_RS14015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LKW27_RS14020	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LKW27_RS14035	COG0750	zinc metalloprotease
LKW27_RS14040	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LKW27_RS14045	COG0575	Belongs to the CDS family
LKW27_RS14055	COG0233	cytoplasmic translational termination
LKW27_RS14060	COG0528	UMP kinase activity
LKW27_RS14065	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LKW27_RS14070	COG0052	Belongs to the universal ribosomal protein uS2 family
LKW27_RS14075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LKW27_RS14080	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LKW27_RS14080	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LKW27_RS14105	COG0789	Transcriptional regulator
LKW27_RS14135	COG2132	Multicopper oxidase
LKW27_RS14165	COG3191	aminopeptidase activity
LKW27_RS14180	COG0488	(ABC) transporter
LKW27_RS14185	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LKW27_RS14190	COG0513	Belongs to the DEAD box helicase family
LKW27_RS14200	COG4651	solute:proton antiporter activity
LKW27_RS14200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LKW27_RS14230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LKW27_RS14240	COG2207	Transcriptional regulator
LKW27_RS14245	COG1012	belongs to the aldehyde dehydrogenase family
LKW27_RS14285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LKW27_RS14295	COG2267	carboxylic ester hydrolase activity
LKW27_RS14315	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_RS14320	COG0028	Belongs to the TPP enzyme family
LKW27_RS14325	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_RS14335	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LKW27_RS14530	COG5484	DNA packaging
LKW27_RS14530	COG3728	DNA packaging
LKW27_RS14565	COG4626	Terminase
LKW27_RS14565	COG1802	Transcriptional regulator
LKW27_RS14690	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LKW27_RS14730	COG0322	excinuclease ABC activity
LKW27_RS14750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LKW27_RS14755	COG0601	transmembrane transport
LKW27_RS14765	COG4172	Belongs to the ABC transporter superfamily
LKW27_RS14770	COG1446	asparaginase
LKW27_RS14790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LKW27_RS14795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LKW27_RS14810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LKW27_RS14825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LKW27_RS14830	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
LKW27_RS14840	COG0693	protein deglycase activity
LKW27_RS14880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LKW27_RS14890	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_RS14910	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LKW27_RS14910	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LKW27_RS14915	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LKW27_RS14915	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LKW27_RS14920	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LKW27_RS14930	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LKW27_RS14940	COG0560	Phosphoserine phosphatase
LKW27_RS14955	COG0583	DNA-binding transcription factor activity
LKW27_RS14960	COG1959	2 iron, 2 sulfur cluster binding
LKW27_RS14985	COG0513	Belongs to the DEAD box helicase family
LKW27_RS15000	COG2900	Belongs to the SlyX family
LKW27_RS15005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LKW27_RS15010	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LKW27_RS15030	COG0477	Major facilitator Superfamily
LKW27_RS15055	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LKW27_RS15060	COG1492	cobalamin metabolic process
LKW27_RS15065	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_RS15100	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LKW27_RS15105	COG0778	Nitroreductase
LKW27_RS15110	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LKW27_RS15115	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LKW27_RS15120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LKW27_RS15135	COG1797	cobyrinic acid a,c-diamide synthase activity
LKW27_RS15140	COG4206	TonB-dependent receptor
LKW27_RS15160	COG3437	response regulator, receiver
LKW27_RS15170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LKW27_RS15175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LKW27_RS15210	COG3278	Belongs to the heme-copper respiratory oxidase family
LKW27_RS15220	COG2217	Heavy metal translocating P-type atpase
LKW27_RS15230	COG0589	response to stress
LKW27_RS15240	COG0318	PFAM AMP-dependent synthetase and ligase
LKW27_RS15260	COG1802	Transcriptional regulator
LKW27_RS15265	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LKW27_RS15280	COG0129	dihydroxy-acid dehydratase activity
LKW27_RS15290	COG4654	Cytochrome c, class I
LKW27_RS15310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LKW27_RS15320	COG4175	Glycine betaine
LKW27_RS15325	COG4176	ABC-type proline glycine betaine transport system permease component
LKW27_RS15330	COG2113	Glycine betaine
LKW27_RS15335	COG2205	protein histidine kinase activity
LKW27_RS15340	COG0745	RESPONSE REGULATOR receiver
LKW27_RS15350	COG0114	fumarate hydratase activity
LKW27_RS15365	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LKW27_RS15370	COG2080	2 iron, 2 sulfur cluster binding
LKW27_RS15375	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LKW27_RS15380	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LKW27_RS15385	COG1451	nucleotide metabolic process
LKW27_RS15450	COG2885	chlorophyll binding
LKW27_RS15465	COG0631	protein serine/threonine phosphatase activity
LKW27_RS15495	COG1562	ergosterol biosynthetic process
LKW27_RS15505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LKW27_RS15515	COG0544	peptidyl-prolyl cis-trans isomerase activity
LKW27_RS15520	COG0740	serine-type endopeptidase activity
LKW27_RS15525	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LKW27_RS15530	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LKW27_RS15555	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LKW27_RS15560	COG1295	ribonuclease BN
LKW27_RS15570	COG0277	FAD linked oxidase domain protein
LKW27_RS15580	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LKW27_RS15595	COG0708	Exodeoxyribonuclease III
LKW27_RS15610	COG3852	Histidine kinase
LKW27_RS15620	COG0174	glutamine synthetase
LKW27_RS15650	COG1187	pseudouridine synthase activity
LKW27_RS15680	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LKW27_RS15685	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LKW27_RS15690	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LKW27_RS15695	COG0330	HflC and HflK could
LKW27_RS15700	COG0330	HflC and HflK could
LKW27_RS15705	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LKW27_RS15710	COG1923	regulation of RNA biosynthetic process
LKW27_RS15715	COG1160	GTP binding
LKW27_RS15730	COG0124	histidyl-tRNA synthetase
LKW27_RS15735	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LKW27_RS15745	COG3063	Type IV pilus biogenesis stability protein PilW
LKW27_RS15750	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LKW27_RS15755	COG0105	UTP biosynthetic process
LKW27_RS15760	COG1187	pseudouridine synthase activity
LKW27_RS15765	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LKW27_RS15770	COG0564	pseudouridine synthase activity
LKW27_RS15780	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LKW27_RS15785	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LKW27_RS15790	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_RS15790	COG0604	alcohol dehydrogenase
LKW27_RS15790	COG3321	synthase
LKW27_RS15800	COG3540	Alkaline phosphatase
LKW27_RS15805	COG0405	Gamma-glutamyltransferase
LKW27_RS15810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LKW27_RS15815	COG3300	MHYT domain
LKW27_RS15815	COG5001	Diguanylate cyclase
LKW27_RS15820	COG0358	DNA primase activity
LKW27_RS15825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LKW27_RS15830	COG0840	transmembrane signaling receptor activity
LKW27_RS15875	COG4948	Mandelate Racemase Muconate Lactonizing
LKW27_RS15880	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_RS15890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LKW27_RS15895	COG0583	DNA-binding transcription factor activity
LKW27_RS15910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LKW27_RS15935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LKW27_RS15950	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LKW27_RS15975	COG3634	alkyl hydroperoxide reductase activity
LKW27_RS16020	COG4774	siderophore transport
LKW27_RS16045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LKW27_RS16050	COG0657	acetylesterase activity
LKW27_RS16060	COG4628	conserved protein (DUF2132)
LKW27_RS16070	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LKW27_RS16090	COG2308	Evidence 4 Homologs of previously reported genes of
LKW27_RS16125	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LKW27_RS16130	COG0840	transmembrane signaling receptor activity
LKW27_RS16135	COG0840	transmembrane signaling receptor activity
LKW27_RS16145	COG0741	lytic transglycosylase activity
LKW27_RS16170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LKW27_RS16175	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LKW27_RS16180	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LKW27_RS16195	COG2850	peptidyl-arginine hydroxylation
LKW27_RS16200	COG1047	Peptidyl-prolyl cis-trans
LKW27_RS16210	COG0756	dUTP diphosphatase activity
LKW27_RS16215	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LKW27_RS16220	COG0504	CTP synthase activity
LKW27_RS16225	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LKW27_RS16245	COG0148	phosphopyruvate hydratase activity
LKW27_RS16250	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LKW27_RS16260	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LKW27_RS16270	COG2833	Protein of unknown function (DUF455)
LKW27_RS16275	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LKW27_RS16280	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LKW27_RS16285	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_RS16290	COG4974	Belongs to the 'phage' integrase family
LKW27_RS16320	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LKW27_RS16325	COG0802	atpase or kinase
LKW27_RS16330	COG0860	N-Acetylmuramoyl-L-alanine amidase
LKW27_RS16345	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LKW27_RS16350	COG0586	Pfam SNARE associated Golgi protein
LKW27_RS16355	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LKW27_RS16365	COG0584	glycerophosphoryl diester phosphodiesterase
LKW27_RS16370	COG2267	carboxylic ester hydrolase activity
LKW27_RS16375	COG1733	regulation of RNA biosynthetic process
LKW27_RS16380	COG0702	epimerase
LKW27_RS16385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LKW27_RS16390	COG1136	(ABC) transporter
LKW27_RS16395	COG0071	Belongs to the small heat shock protein (HSP20) family
LKW27_RS16415	COG0457	Tetratricopeptide repeat
LKW27_RS16415	COG0463	Glycosyl transferase, family 2
LKW27_RS16460	COG1132	(ABC) transporter
LKW27_RS16475	COG1007	ATP synthesis coupled electron transport
LKW27_RS16490	COG0713	ATP synthesis coupled electron transport
LKW27_RS16500	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LKW27_RS16505	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LKW27_RS16510	COG1034	ATP synthesis coupled electron transport
LKW27_RS16515	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LKW27_RS16520	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LKW27_RS16525	COG0649	NAD binding
LKW27_RS16530	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LKW27_RS16535	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LKW27_RS16540	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LKW27_RS16555	COG0149	triose-phosphate isomerase activity
LKW27_RS16560	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_RS16560	COG3321	synthase
LKW27_RS16560	COG0604	alcohol dehydrogenase
LKW27_RS16565	COG1185	polyribonucleotide nucleotidyltransferase activity
LKW27_RS16570	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LKW27_RS16575	COG0436	Aminotransferase
LKW27_RS16585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LKW27_RS16590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LKW27_RS16600	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LKW27_RS16620	COG0542	response to heat
LKW27_RS16625	COG0314	molybdopterin synthase activity
LKW27_RS16650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LKW27_RS16655	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LKW27_RS16660	COG0303	'Molybdopterin
LKW27_RS16665	COG1763	Mo-molybdopterin cofactor biosynthetic process
LKW27_RS16680	COG0436	Aminotransferase
LKW27_RS16685	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LKW27_RS16750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LKW27_RS16755	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LKW27_RS16770	COG0359	binds to the 23S rRNA
LKW27_RS16775	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LKW27_RS16785	COG0360	Binds together with S18 to 16S ribosomal RNA
LKW27_RS16790	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LKW27_RS16795	COG0443	Heat shock 70 kDa protein
LKW27_RS16800	COG0484	heat shock protein binding
LKW27_RS16810	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LKW27_RS16820	COG0066	3-isopropylmalate dehydratase activity
LKW27_RS16825	COG0473	3-isopropylmalate dehydrogenase activity
LKW27_RS16835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LKW27_RS16845	COG0101	tRNA pseudouridine synthase activity
LKW27_RS16850	COG0135	phosphoribosylanthranilate isomerase activity
LKW27_RS16855	COG0133	tryptophan synthase activity
LKW27_RS16860	COG0159	tryptophan synthase activity
LKW27_RS16865	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LKW27_RS16870	COG0762	integral membrane protein
LKW27_RS16885	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LKW27_RS16910	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LKW27_RS16915	COG5001	Diguanylate cyclase
LKW27_RS16915	COG4251	negative regulation of phosphorylation
LKW27_RS16915	COG2203	Gaf domain
LKW27_RS16915	COG3706	GGDEF domain
LKW27_RS16925	COG3064	Membrane
LKW27_RS16930	COG1472	Belongs to the glycosyl hydrolase 3 family
LKW27_RS16940	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LKW27_RS16945	COG1381	Involved in DNA repair and RecF pathway recombination
LKW27_RS16950	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LKW27_RS16955	COG0571	ribonuclease III activity
LKW27_RS16965	COG0681	Belongs to the peptidase S26 family
LKW27_RS16970	COG0481	GTPase activity
LKW27_RS16975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LKW27_RS17000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LKW27_RS17005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LKW27_RS17010	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_RS17015	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LKW27_RS17020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LKW27_RS17025	COG0416	fatty acid biosynthetic process
LKW27_RS17030	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LKW27_RS17035	COG1399	metal-binding, possibly nucleic acid-binding protein
LKW27_RS17040	COG0424	maF-like protein
LKW27_RS17045	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LKW27_RS17050	COG0616	signal peptide processing
LKW27_RS17050	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LKW27_RS17075	COG1530	ribonuclease E activity
LKW27_RS17080	COG3022	response to hydroperoxide
LKW27_RS17090	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LKW27_RS17090	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LKW27_RS17100	COG0728	peptidoglycan biosynthetic process
LKW27_RS17105	COG0268	Binds directly to 16S ribosomal RNA
LKW27_RS17110	COG0579	oxidoreductase
LKW27_RS17120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LKW27_RS17125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LKW27_RS17150	COG0727	PFAM Uncharacterised protein family (UPF0153)
LKW27_RS17155	COG1522	sequence-specific DNA binding
LKW27_RS17160	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LKW27_RS17170	COG3483	tryptophan 2,3-dioxygenase activity
LKW27_RS17200	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LKW27_RS17205	COG2916	Histone family protein nucleoid-structuring protein H-NS
LKW27_RS17210	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LKW27_RS17215	COG0513	Belongs to the DEAD box helicase family
LKW27_RS17220	COG2321	neutral zinc metallopeptidase
LKW27_RS17235	COG0717	Belongs to the dCTP deaminase family
LKW27_RS17250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LKW27_RS17255	COG2366	antibiotic biosynthetic process
LKW27_RS17270	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LKW27_RS17295	COG4603	Belongs to the binding-protein-dependent transport system permease family
LKW27_RS17300	COG3845	ABC transporter
LKW27_RS17320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LKW27_RS17335	COG3447	MASE1 domain protein
LKW27_RS17335	COG5002	protein histidine kinase activity
LKW27_RS17335	COG5001	Diguanylate cyclase
LKW27_RS17355	COG0251	oxidation-reduction process
LKW27_RS17395	COG0405	Gamma-glutamyltransferase
LKW27_RS17405	COG2186	Transcriptional regulator
LKW27_RS17420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LKW27_RS17450	COG1301	dicarboxylic acid transport
LKW27_RS17455	COG0840	transmembrane signaling receptor activity
LKW27_RS17460	COG2186	Transcriptional regulator
LKW27_RS17465	COG1953	Uracil, thiamine, allantoin
LKW27_RS17485	COG0280	phosphate acetyltransferase
LKW27_RS17485	COG0281	malic enzyme
LKW27_RS17500	COG1116	anion transmembrane transporter activity
LKW27_RS17505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LKW27_RS17530	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LKW27_RS17550	COG0829	nickel cation binding
LKW27_RS17555	COG0840	transmembrane signaling receptor activity
LKW27_RS17560	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_RS17615	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LKW27_RS17620	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LKW27_RS17630	COG0084	hydrolase, TatD family'
LKW27_RS17635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LKW27_RS17640	COG0714	Associated with various cellular activities
LKW27_RS17660	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LKW27_RS17685	COG0805	protein transport
LKW27_RS17690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LKW27_RS17695	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LKW27_RS17700	COG0537	adenosine 5'-monophosphoramidase activity
LKW27_RS17715	COG0140	phosphoribosyl-ATP diphosphatase activity
LKW27_RS17720	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LKW27_RS17725	COG0107	imidazoleglycerol-phosphate synthase activity
LKW27_RS17735	COG1301	dicarboxylic acid transport
LKW27_RS17740	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LKW27_RS17770	COG0438	transferase activity, transferring glycosyl groups
LKW27_RS17790	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LKW27_RS17800	COG0131	Imidazoleglycerol-phosphate dehydratase
LKW27_RS17805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LKW27_RS17835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LKW27_RS17840	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LKW27_RS17845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LKW27_RS17850	COG5007	Belongs to the BolA IbaG family
LKW27_RS17855	COG0842	Transport permease protein
LKW27_RS17860	COG1131	(ABC) transporter
LKW27_RS17880	COG2853	Lipoprotein
LKW27_RS17885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LKW27_RS17890	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LKW27_RS17895	COG1127	ABC transporter
LKW27_RS17900	COG1126	abc transporter atp-binding protein
LKW27_RS17905	COG0765	amino acid transport
LKW27_RS17910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LKW27_RS17920	COG0067	glutamate synthase
LKW27_RS17920	COG0069	glutamate synthase activity
LKW27_RS17920	COG0070	glutamate synthase
LKW27_RS17940	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LKW27_RS17945	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LKW27_RS17950	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LKW27_RS17990	COG1965	Belongs to the frataxin family
LKW27_RS18020	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
LKW27_RS18025	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LKW27_RS18030	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LKW27_RS18035	COG1333	cytochrome c biogenesis protein
LKW27_RS18045	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LKW27_RS18055	COG1560	Kdo2-lipid A biosynthetic process
LKW27_RS18065	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LKW27_RS18080	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LKW27_RS18085	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LKW27_RS18085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LKW27_RS18120	COG1953	Uracil, thiamine, allantoin
LKW27_RS18130	COG0493	'glutamate synthase
LKW27_RS18135	COG1309	transcriptional regulator
LKW27_RS18145	COG1216	Glycosyl transferase, family 2
LKW27_RS18165	COG0367	asparagine synthase
LKW27_RS18170	COG0438	transferase activity, transferring glycosyl groups
LKW27_RS18175	COG0367	asparagine synthase
LKW27_RS18185	COG0438	transferase activity, transferring glycosyl groups
LKW27_RS18190	COG2226	methyltransferase
LKW27_RS18225	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LKW27_RS18240	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LKW27_RS18245	COG0459	protein refolding
LKW27_RS18250	COG0166	Belongs to the GPI family
LKW27_RS18255	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LKW27_RS18260	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LKW27_RS18270	COG0840	transmembrane signaling receptor activity
LKW27_RS18275	COG4608	Belongs to the ABC transporter superfamily
LKW27_RS18280	COG0444	Belongs to the ABC transporter superfamily
LKW27_RS18285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LKW27_RS18290	COG0747	negative chemotaxis
LKW27_RS18295	COG1473	amidohydrolase
LKW27_RS18315	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LKW27_RS18320	COG1765	OsmC-like protein
LKW27_RS18325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LKW27_RS18330	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LKW27_RS18350	COG4970	Tfp pilus assembly protein FimT
LKW27_RS18400	COG1178	ABC-type Fe3 transport system permease component
LKW27_RS18405	COG3842	ATPase activity
LKW27_RS18420	COG0540	Belongs to the ATCase OTCase family
LKW27_RS18425	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LKW27_RS18430	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LKW27_RS18435	COG1678	Uncharacterized ACR, COG1678
LKW27_RS18440	COG0415	Belongs to the DNA photolyase family
LKW27_RS18445	COG0643	Histidine kinase
LKW27_RS18445	COG2198	Histidine kinase
LKW27_RS18450	COG0840	transmembrane signaling receptor activity
LKW27_RS18455	COG0835	chemotaxis
LKW27_RS18470	COG1773	rubredoxin
LKW27_RS18475	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LKW27_RS18475	COG0352	thiamine-phosphate diphosphorylase activity
LKW27_RS18475	COG0351	phosphomethylpyrimidine kinase
LKW27_RS18480	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LKW27_RS18490	COG0138	bifunctional purine biosynthesis protein purh
LKW27_RS18495	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LKW27_RS18500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LKW27_RS18510	COG1238	metal cluster binding
LKW27_RS18520	COG0517	IMP dehydrogenase activity
LKW27_RS18520	COG1125	glycine betaine transport
LKW27_RS18530	COG0012	GTP binding
LKW27_RS18535	COG0633	Ferredoxin
LKW27_RS18535	COG3217	Mosc domain protein beta barrel domain protein
LKW27_RS18540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LKW27_RS18555	COG1024	Enoyl-CoA hydratase
LKW27_RS18560	COG3829	transcription factor binding
LKW27_RS18565	COG0431	NADPH-dependent FMN reductase
LKW27_RS18590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LKW27_RS18595	COG2205	protein histidine kinase activity
LKW27_RS18605	COG2204	response regulator
LKW27_RS18615	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LKW27_RS18650	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LKW27_RS18660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LKW27_RS18670	COG2264	protein methyltransferase activity
LKW27_RS18675	COG0439	Biotin carboxylase
LKW27_RS18680	COG0511	ligase activity, forming carbon-carbon bonds
LKW27_RS18685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LKW27_RS18695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LKW27_RS18705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LKW27_RS18715	COG0312	modulator of DNA gyrase
LKW27_RS18720	COG0154	amidase activity
LKW27_RS18725	COG0772	Belongs to the SEDS family
LKW27_RS18730	COG3150	esterase
LKW27_RS18740	COG0557	exoribonuclease II activity
LKW27_RS18750	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LKW27_RS18755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LKW27_RS18760	COG1414	Transcriptional regulator
LKW27_RS18785	COG0575	Belongs to the CDS family
LKW27_RS18790	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LKW27_RS18805	COG0840	transmembrane signaling receptor activity
LKW27_RS18810	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LKW27_RS18820	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LKW27_RS18825	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LKW27_RS18835	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LKW27_RS18840	COG1181	Belongs to the D-alanine--D-alanine ligase family
LKW27_RS18845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LKW27_RS18850	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LKW27_RS18855	COG0772	Belongs to the SEDS family
LKW27_RS18860	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LKW27_RS18865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LKW27_RS18870	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LKW27_RS18875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LKW27_RS18885	COG3116	cell division
LKW27_RS18890	COG0275	rRNA processing
LKW27_RS18895	COG2001	Belongs to the MraZ family
LKW27_RS18900	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LKW27_RS18905	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LKW27_RS18920	COG0523	cobalamin synthesis protein
LKW27_RS18925	COG5002	protein histidine kinase activity
LKW27_RS18925	COG5001	Diguanylate cyclase
LKW27_RS18925	COG3447	MASE1 domain protein
LKW27_RS18945	COG1649	PFAM Uncharacterised BCR, COG1649
LKW27_RS18950	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LKW27_RS18960	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LKW27_RS18965	COG0625	glutathione transferase activity
LKW27_RS19000	COG4269	membrane
LKW27_RS19015	COG3266	domain, Protein
LKW27_RS19020	COG3267	Type II secretory pathway component ExeA
LKW27_RS19020	COG3409	Peptidoglycan-binding domain 1 protein
LKW27_RS19075	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LKW27_RS19085	COG0519	Catalyzes the synthesis of GMP from XMP
LKW27_RS19100	COG0840	transmembrane signaling receptor activity
LKW27_RS19110	COG1473	amidohydrolase
LKW27_RS19125	COG0243	molybdopterin cofactor binding
LKW27_RS19165	COG1335	isochorismatase
LKW27_RS19170	COG1741	Belongs to the pirin family
LKW27_RS19175	COG0583	DNA-binding transcription factor activity
LKW27_RS19185	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LKW27_RS19190	COG0129	dihydroxy-acid dehydratase activity
LKW27_RS19200	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LKW27_RS19205	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LKW27_RS19265	COG1272	protein, Hemolysin III
LKW27_RS19310	COG0477	Major facilitator Superfamily
LKW27_RS19320	COG3945	hemerythrin HHE cation binding domain
LKW27_RS19335	COG0288	reversible hydration of carbon dioxide
LKW27_RS19340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LKW27_RS19345	COG2181	nitrate reductase activity
LKW27_RS19355	COG1140	nitrate reductase beta subunit
LKW27_RS19360	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
LKW27_RS19365	COG2223	nitrite transmembrane transporter activity
LKW27_RS19380	COG4771	TonB-dependent receptor
LKW27_RS19395	COG2197	response regulator
LKW27_RS19400	COG3850	Histidine kinase
LKW27_RS19410	COG1285	pathogenesis
LKW27_RS19430	COG0583	DNA-binding transcription factor activity
LKW27_RS19440	COG0277	FAD linked oxidase domain protein
LKW27_RS19465	COG2733	membrane
LKW27_RS19490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LKW27_RS19500	COG2084	Dehydrogenase
LKW27_RS19505	COG2823	Periplasmic or secreted lipoprotein
LKW27_RS19510	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LKW27_RS19515	COG0792	nuclease activity
LKW27_RS19520	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LKW27_RS19525	COG0443	Heat shock 70 kDa protein
LKW27_RS19535	COG0203	ribosomal protein L17
LKW27_RS19540	COG0202	RNA polymerase activity
LKW27_RS19545	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LKW27_RS19550	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LKW27_RS19555	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LKW27_RS19560	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LKW27_RS19565	COG0201	protein transport
LKW27_RS19570	COG0200	Binds to the 23S rRNA
LKW27_RS19575	COG1841	ribosomal large subunit assembly
LKW27_RS19580	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LKW27_RS19585	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LKW27_RS19590	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LKW27_RS19595	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LKW27_RS19600	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LKW27_RS19605	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LKW27_RS19610	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LKW27_RS19615	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LKW27_RS19635	COG0395	ABC-type sugar transport system, permease component
LKW27_RS19645	COG3842	ATPase activity
LKW27_RS19650	COG3842	ATPase activity
LKW27_RS19660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LKW27_RS19675	COG0463	Glycosyl transferase, family 2
LKW27_RS19690	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LKW27_RS19695	COG0783	Belongs to the Dps family
LKW27_RS19705	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LKW27_RS19745	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LKW27_RS19750	COG0134	indole-3-glycerol-phosphate synthase activity
LKW27_RS19760	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LKW27_RS19765	COG1280	lysine exporter protein (LysE YggA)
LKW27_RS19770	COG0512	Glutamine amidotransferase of anthranilate synthase
LKW27_RS19795	COG0741	lytic transglycosylase activity
LKW27_RS19795	COG1196	nuclear chromosome segregation
LKW27_RS19795	COG0739	heme binding
LKW27_RS19800	COG0500	methyltransferase
LKW27_RS19920	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LKW27_RS19925	COG4789	Type iii secretion
LKW27_RS19940	COG4790	Type iii secretion
LKW27_RS19945	COG4794	Type iii secretion
LKW27_RS19965	COG2207	Transcriptional regulator
LKW27_RS19985	COG0546	phosphoglycolate phosphatase activity
LKW27_RS19995	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LKW27_RS20000	COG2967	ApaG domain
LKW27_RS20015	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LKW27_RS20035	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LKW27_RS20050	COG0659	secondary active sulfate transmembrane transporter activity
LKW27_RS20055	COG0653	protein targeting
LKW27_RS20065	COG4178	(ABC) transporter
LKW27_RS20085	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
LKW27_RS20090	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LKW27_RS20095	COG1137	ATPase activity
LKW27_RS20105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LKW27_RS20115	COG0018	arginyl-trna synthetase
LKW27_RS20145	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LKW27_RS20160	COG1942	4-Oxalocrotonate Tautomerase
LKW27_RS20165	COG2814	Major facilitator Superfamily
LKW27_RS20170	COG0121	glutamine amidotransferase
LKW27_RS20250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LKW27_RS20255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LKW27_RS20270	COG3245	cytochrome
LKW27_RS20320	COG1201	RNA secondary structure unwinding
LKW27_RS20325	COG1793	dna ligase
LKW27_RS20330	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LKW27_RS20330	COG1793	dna ligase
LKW27_RS20335	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LKW27_RS20340	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LKW27_RS20345	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LKW27_RS20350	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LKW27_RS20355	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LKW27_RS20360	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LKW27_RS20370	COG0356	it plays a direct role in the translocation of protons across the membrane
LKW27_RS20380	COG2921	Belongs to the UPF0250 family
LKW27_RS20385	COG0321	lipoyl(octanoyl) transferase activity
LKW27_RS20390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LKW27_RS20410	COG0745	RESPONSE REGULATOR receiver
LKW27_RS20415	COG2205	protein histidine kinase activity
LKW27_RS20420	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LKW27_RS20425	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LKW27_RS20430	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LKW27_RS20445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LKW27_RS20450	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LKW27_RS20465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LKW27_RS20475	COG0678	peroxiredoxin activity
LKW27_RS20480	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LKW27_RS20485	COG0255	Belongs to the universal ribosomal protein uL29 family
LKW27_RS20490	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LKW27_RS20495	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LKW27_RS20500	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LKW27_RS20505	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LKW27_RS20510	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LKW27_RS20515	COG0089	rRNA binding
LKW27_RS20520	COG0088	Forms part of the polypeptide exit tunnel
LKW27_RS20525	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LKW27_RS20530	COG0051	transcription antitermination factor activity, RNA binding
LKW27_RS20535	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LKW27_RS20540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LKW27_RS20545	COG0049	tRNA binding
LKW27_RS20550	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LKW27_RS20555	COG1686	Belongs to the peptidase S11 family
LKW27_RS20560	COG2945	thiolester hydrolase activity
LKW27_RS20575	COG1981	membrane
LKW27_RS20585	COG0598	Magnesium transport protein CorA
LKW27_RS20590	COG0519	Catalyzes the synthesis of GMP from XMP
LKW27_RS20590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LKW27_RS20595	COG1846	Transcriptional regulator
LKW27_RS20605	COG1566	PFAM secretion protein HlyD family protein
LKW27_RS20615	COG0412	Dienelactone hydrolase
LKW27_RS20620	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_RS20625	COG2095	MarC family integral membrane protein
LKW27_RS20630	COG0745	RESPONSE REGULATOR receiver
LKW27_RS20635	COG2205	protein histidine kinase activity
LKW27_RS20640	COG4452	Inner membrane protein CreD
LKW27_RS20660	COG3237	CsbD-like
LKW27_RS20685	COG1127	ABC transporter
LKW27_RS20690	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LKW27_RS20710	COG1760	l-serine dehydratase
LKW27_RS20715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LKW27_RS20720	COG0765	amino acid transport
LKW27_RS20735	COG0768	penicillin binding
LKW27_RS20740	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LKW27_RS20750	COG1077	Cell shape determining protein MreB Mrl
LKW27_RS20755	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LKW27_RS20760	COG0154	amidase activity
LKW27_RS20765	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LKW27_RS20775	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LKW27_RS20780	COG0708	Exodeoxyribonuclease III
LKW27_RS20790	COG2814	Major facilitator Superfamily
LKW27_RS20795	COG0583	DNA-binding transcription factor activity
LKW27_RS20815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LKW27_RS20820	COG0471	metal ion transport
LKW27_RS20825	COG0501	Belongs to the peptidase M48B family
LKW27_RS20845	COG2211	Major facilitator Superfamily
LKW27_RS20850	COG0745	RESPONSE REGULATOR receiver
LKW27_RS20860	COG0477	Major facilitator Superfamily
LKW27_RS20880	COG1215	transferase activity, transferring glycosyl groups
LKW27_RS20925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LKW27_RS20930	COG0625	glutathione transferase activity
LKW27_RS20950	COG0747	negative chemotaxis
LKW27_RS20960	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LKW27_RS20965	COG0477	Major facilitator Superfamily
LKW27_RS20975	COG0386	Belongs to the glutathione peroxidase family
LKW27_RS21005	COG0247	lactate metabolic process
LKW27_RS21015	COG0277	FAD linked oxidase domain protein
LKW27_RS21060	COG0004	ammonium transporteR
LKW27_RS21065	COG0347	Belongs to the P(II) protein family
LKW27_RS21075	COG0606	chelatase, subunit chli
LKW27_RS21085	COG4191	Histidine kinase
LKW27_RS21090	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_RS21095	COG0840	transmembrane signaling receptor activity
LKW27_RS21105	COG0583	DNA-binding transcription factor activity
LKW27_RS21160	COG1410	methionine synthase
LKW27_RS21160	COG0646	methionine synthase
LKW27_RS21185	COG0765	amino acid transport
LKW27_RS21190	COG0765	amino acid transport
LKW27_RS21195	COG1126	abc transporter atp-binding protein
LKW27_RS21200	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
LKW27_RS21215	COG0583	DNA-binding transcription factor activity
LKW27_RS21245	COG0583	DNA-binding transcription factor activity
LKW27_RS21285	COG2326	polyphosphate kinase activity
LKW27_RS21295	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LKW27_RS21335	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_RS21340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LKW27_RS21355	COG0583	DNA-binding transcription factor activity
LKW27_RS21390	COG0840	transmembrane signaling receptor activity
LKW27_RS21445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LKW27_RS21475	COG2423	ornithine cyclodeaminase activity
LKW27_RS21485	COG2271	Major facilitator Superfamily
LKW27_RS21490	COG0625	glutathione transferase activity
LKW27_RS21510	COG1960	acyl-CoA dehydrogenase activity
LKW27_RS21520	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LKW27_RS21525	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LKW27_RS21535	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LKW27_RS21540	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LKW27_RS21565	COG1309	transcriptional regulator
LKW27_RS21575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LKW27_RS21580	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LKW27_RS21595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LKW27_RS21600	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LKW27_RS21605	COG2894	cell division
LKW27_RS21610	COG0850	regulation of cytokinetic process
LKW27_RS21620	COG1183	phosphatidylcholine synthase activity
LKW27_RS21630	COG2423	ornithine cyclodeaminase activity
LKW27_RS21640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LKW27_RS21650	COG0501	Belongs to the peptidase M48B family
LKW27_RS21655	COG1414	Transcriptional regulator
LKW27_RS21680	COG1116	anion transmembrane transporter activity
LKW27_RS21695	COG0583	DNA-binding transcription factor activity
LKW27_RS21710	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LKW27_RS21730	COG2233	PERMEase
LKW27_RS21745	COG2050	protein possibly involved in aromatic compounds catabolism
LKW27_RS21750	COG2096	Adenosyltransferase
LKW27_RS21765	COG0277	FAD linked oxidase domain protein
LKW27_RS21855	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LKW27_RS21870	COG3411	Ferredoxin
LKW27_RS21905	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
LKW27_RS21925	COG2272	Belongs to the type-B carboxylesterase lipase family
LKW27_RS21940	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LKW27_RS21940	COG0546	phosphoglycolate phosphatase activity
LKW27_RS21945	COG0277	FAD linked oxidase domain protein
LKW27_RS21965	COG0493	'glutamate synthase
LKW27_RS21990	COG1192	Involved in chromosome partitioning
LKW27_RS21995	COG1280	lysine exporter protein (LysE YggA)
LKW27_RS22000	COG0357	Ribosomal RNA small subunit methyltransferase G
LKW27_RS22005	COG0445	tRNA wobble uridine modification
LKW27_RS22025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LKW27_RS22030	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LKW27_RS22050	COG0642	Histidine kinase
LKW27_RS22055	COG0745	RESPONSE REGULATOR receiver
LKW27_RS22095	COG2217	Heavy metal translocating P-type atpase
LKW27_RS22105	COG0789	Transcriptional regulator
LKW27_RS22110	COG0183	Belongs to the thiolase family
LKW27_RS22135	COG2715	membrane protein required for spore maturation
LKW27_RS22140	COG2974	May be involved in recombination
LKW27_RS22245	COG3181	Tripartite tricarboxylate transporter family receptor