locus-tag	class	description
APS58_RS00010	COG0252	asparaginase activity
APS58_RS00015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APS58_RS00025	COG1643	Atp-dependent helicase
APS58_RS00035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APS58_RS00040	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APS58_RS00040	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
APS58_RS00055	COG1054	Belongs to the UPF0176 family
APS58_RS00060	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
APS58_RS00065	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APS58_RS00070	COG4208	sulfate ABC transporter
APS58_RS00075	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
APS58_RS00080	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
APS58_RS00100	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
APS58_RS00120	COG2011	ABC-type metal ion transport system permease component
APS58_RS00125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APS58_RS00135	COG2814	Major facilitator Superfamily
APS58_RS00140	COG0583	DNA-binding transcription factor activity
APS58_RS00145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APS58_RS00160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APS58_RS00175	COG5002	protein histidine kinase activity
APS58_RS00260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APS58_RS00280	COG4770	biotin carboxylase activity
APS58_RS00290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
APS58_RS00295	COG1703	isobutyryl-CoA mutase activity
APS58_RS00305	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
APS58_RS00305	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
APS58_RS00310	COG1802	Transcriptional regulator
APS58_RS00375	COG0840	transmembrane signaling receptor activity
APS58_RS00390	COG3039	Transposase
APS58_RS00405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APS58_RS00425	COG2878	Part of a membrane complex involved in electron transport
APS58_RS00430	COG0840	transmembrane signaling receptor activity
APS58_RS00440	COG2171	N-acyltransferase activity
APS58_RS00450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APS58_RS00455	COG2890	protein-(glutamine-N5) methyltransferase activity
APS58_RS00460	COG0488	(ABC) transporter
APS58_RS00465	COG1028	Short-chain dehydrogenase reductase Sdr
APS58_RS00470	COG0183	Belongs to the thiolase family
APS58_RS00475	COG3243	poly(R)-hydroxyalkanoic acid synthase
APS58_RS00505	COG0515	serine threonine protein kinase
APS58_RS00515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APS58_RS00520	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
APS58_RS00545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APS58_RS00550	COG0508	dehydrogenase complex catalyzes the overall conversion of
APS58_RS00555	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
APS58_RS00565	COG4566	intracellular signal transduction
APS58_RS00570	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APS58_RS00585	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
APS58_RS00590	COG0167	dihydroorotate dehydrogenase activity
APS58_RS00610	COG0579	oxidoreductase
APS58_RS00635	COG0633	Ferredoxin
APS58_RS00640	COG0443	Heat shock 70 kDa protein
APS58_RS00645	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APS58_RS00655	COG0822	iron-sulfur transferase activity
APS58_RS00660	COG1104	cysteine desulfurase activity
APS58_RS00665	COG1959	2 iron, 2 sulfur cluster binding
APS58_RS00670	COG0556	nucleotide-excision repair
APS58_RS00680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APS58_RS00695	COG0840	transmembrane signaling receptor activity
APS58_RS00710	COG1739	Uncharacterized protein family UPF0029
APS58_RS00730	COG0154	amidase activity
APS58_RS00735	COG3181	Tripartite tricarboxylate transporter family receptor
APS58_RS00740	COG3048	D-serine ammonia-lyase activity
APS58_RS00775	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
APS58_RS00845	COG1024	Enoyl-CoA hydratase
APS58_RS00850	COG0123	including yeast histone deacetylase and acetoin utilization protein
APS58_RS00855	COG0714	Associated with various cellular activities
APS58_RS00870	COG2951	lytic endotransglycosylase activity
APS58_RS00900	COG0683	leucine binding
APS58_RS00915	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APS58_RS00920	COG0683	leucine binding
APS58_RS00935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APS58_RS00940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APS58_RS00945	COG1116	anion transmembrane transporter activity
APS58_RS00950	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APS58_RS00965	COG0724	RNA recognition motif
APS58_RS00975	COG0626	cystathionine gamma-synthase activity
APS58_RS00990	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
APS58_RS01005	COG0194	GDP metabolic process
APS58_RS01010	COG3958	Transketolase
APS58_RS01015	COG3959	Transketolase, thiamine diphosphate binding domain
APS58_RS01020	COG2223	nitrite transmembrane transporter activity
APS58_RS01035	COG0745	RESPONSE REGULATOR receiver
APS58_RS01045	COG0840	transmembrane signaling receptor activity
APS58_RS01050	COG2198	Histidine kinase
APS58_RS01050	COG0643	Histidine kinase
APS58_RS01070	COG0516	GMP reductase activity
APS58_RS01070	COG0517	IMP dehydrogenase activity
APS58_RS01075	COG0840	transmembrane signaling receptor activity
APS58_RS01085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APS58_RS01100	COG0840	transmembrane signaling receptor activity
APS58_RS01105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APS58_RS01115	COG0243	molybdopterin cofactor binding
APS58_RS01120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APS58_RS01130	COG5297	Belongs to the glycosyl hydrolase family 6
APS58_RS01130	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
APS58_RS01135	COG1607	acyl-coa hydrolase
APS58_RS01140	COG0288	reversible hydration of carbon dioxide
APS58_RS01155	COG2081	HI0933 family
APS58_RS01160	COG0640	Transcriptional regulator
APS58_RS01180	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APS58_RS01185	COG1610	YqeY-like protein
APS58_RS01190	COG0625	glutathione transferase activity
APS58_RS01200	COG0583	DNA-binding transcription factor activity
APS58_RS01205	COG0473	3-isopropylmalate dehydrogenase activity
APS58_RS01210	COG1752	Esterase of the alpha-beta hydrolase superfamily
APS58_RS01215	COG0477	Major facilitator Superfamily
APS58_RS01230	COG2721	sulfolactate sulfo-lyase activity
APS58_RS01245	COG0312	modulator of DNA gyrase
APS58_RS01250	COG3028	Belongs to the UPF0307 family
APS58_RS01255	COG0521	Mo-molybdopterin cofactor biosynthetic process
APS58_RS01260	COG1045	serine acetyltransferase
APS58_RS01275	COG4555	ABC transporter
APS58_RS01290	COG0483	inositol monophosphate 1-phosphatase activity
APS58_RS01305	COG1132	(ABC) transporter
APS58_RS01315	COG3437	response regulator, receiver
APS58_RS01320	COG0784	Response regulator, receiver
APS58_RS01320	COG2205	protein histidine kinase activity
APS58_RS01320	COG5002	protein histidine kinase activity
APS58_RS01375	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APS58_RS01380	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APS58_RS01395	COG3209	COG3209 Rhs family protein
APS58_RS01420	COG5002	protein histidine kinase activity
APS58_RS01420	COG5001	Diguanylate cyclase
APS58_RS01420	COG3447	MASE1 domain protein
APS58_RS01425	COG1968	undecaprenyl-diphosphatase activity
APS58_RS01460	COG3275	phosphorelay sensor kinase activity
APS58_RS01465	COG3279	Response regulator of the LytR AlgR family
APS58_RS01470	COG1280	lysine exporter protein (LysE YggA)
APS58_RS01490	COG3585	molybdate ion transport
APS58_RS01490	COG2005	Transcriptional regulator
APS58_RS01510	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
APS58_RS01515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APS58_RS01520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APS58_RS01525	COG0366	Alpha amylase catalytic
APS58_RS01530	COG0366	Alpha amylase catalytic
APS58_RS01535	COG0668	transmembrane transport
APS58_RS01555	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
APS58_RS01560	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APS58_RS01565	COG0142	geranyltranstransferase activity
APS58_RS01570	COG1722	exodeoxyribonuclease VII activity
APS58_RS01625	COG0628	permease
APS58_RS01635	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
APS58_RS01640	COG0181	hydroxymethylbilane synthase activity
APS58_RS01660	COG0488	(ABC) transporter
APS58_RS01670	COG0501	Belongs to the peptidase M48B family
APS58_RS01675	COG0525	valine-tRNA ligase activity
APS58_RS01680	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APS58_RS01690	COG0425	Belongs to the sulfur carrier protein TusA family
APS58_RS01695	COG2816	NAD+ diphosphatase activity
APS58_RS01735	COG0583	DNA-binding transcription factor activity
APS58_RS01740	COG1960	acyl-CoA dehydrogenase activity
APS58_RS01745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APS58_RS01785	COG0617	tRNA 3'-terminal CCA addition
APS58_RS01795	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APS58_RS01800	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APS58_RS01830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APS58_RS01850	COG0840	transmembrane signaling receptor activity
APS58_RS01855	COG1304	FMN binding
APS58_RS01865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APS58_RS01870	COG0840	transmembrane signaling receptor activity
APS58_RS01905	COG0165	Argininosuccinate lyase
APS58_RS01910	COG3275	phosphorelay sensor kinase activity
APS58_RS01920	COG0165	Argininosuccinate lyase
APS58_RS01930	COG0412	Dienelactone hydrolase
APS58_RS01960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APS58_RS01965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APS58_RS02005	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
APS58_RS02090	COG0516	GMP reductase activity
APS58_RS02140	COG2204	response regulator
APS58_RS02145	COG5002	protein histidine kinase activity
APS58_RS02150	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
APS58_RS02165	COG2814	Major facilitator Superfamily
APS58_RS02170	COG3447	MASE1 domain protein
APS58_RS02170	COG5001	Diguanylate cyclase
APS58_RS02170	COG5002	protein histidine kinase activity
APS58_RS02175	COG0513	Belongs to the DEAD box helicase family
APS58_RS02180	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
APS58_RS02190	COG2154	pterin-4-alpha-carbinolamine dehydratase
APS58_RS02195	COG1162	GTPase activity
APS58_RS02200	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
APS58_RS02210	COG0335	large ribosomal subunit rRNA binding
APS58_RS02215	COG0336	Belongs to the RNA methyltransferase TrmD family
APS58_RS02220	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APS58_RS02225	COG0228	four-way junction DNA binding
APS58_RS02240	COG0306	phosphate transporter
APS58_RS02245	COG1392	Phosphate transport regulator
APS58_RS02250	COG2885	chlorophyll binding
APS58_RS02250	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
APS58_RS02270	COG0559	Belongs to the binding-protein-dependent transport system permease family
APS58_RS02275	COG0840	transmembrane signaling receptor activity
APS58_RS02280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APS58_RS02285	COG1573	uracil-dna glycosylase
APS58_RS02300	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
APS58_RS02305	COG1674	ftsk spoiiie
APS58_RS02310	COG0492	ferredoxin-NADP+ reductase activity
APS58_RS02315	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APS58_RS02320	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APS58_RS02325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APS58_RS02340	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APS58_RS02340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APS58_RS02345	COG3866	Pectate lyase
APS58_RS02360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APS58_RS02365	COG3132	Protein of unknown function, DUF480
APS58_RS02370	COG1960	acyl-CoA dehydrogenase activity
APS58_RS02390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APS58_RS02395	COG0840	transmembrane signaling receptor activity
APS58_RS02400	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APS58_RS02410	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APS58_RS02420	COG0196	riboflavin kinase activity
APS58_RS02430	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APS58_RS02440	COG1609	Transcriptional regulator
APS58_RS02450	COG4149	molybdate abc transporter
APS58_RS02455	COG1177	transmembrane transport
APS58_RS02460	COG3842	ATPase activity
APS58_RS02465	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APS58_RS02475	COG1283	sodium-dependent phosphate transmembrane transporter activity
APS58_RS02490	COG0583	DNA-binding transcription factor activity
APS58_RS02525	COG0697	spore germination
APS58_RS02625	COG2814	Major facilitator Superfamily
APS58_RS02675	COG1301	dicarboxylic acid transport
APS58_RS02680	COG5599	Phosphatase
APS58_RS02700	COG3038	cytochrome b561
APS58_RS02715	COG4770	biotin carboxylase activity
APS58_RS02720	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
APS58_RS02725	COG4336	lyase activity
APS58_RS02730	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
APS58_RS02735	COG2814	Major facilitator Superfamily
APS58_RS02755	COG2205	protein histidine kinase activity
APS58_RS02760	COG1304	FMN binding
APS58_RS02785	COG5001	Diguanylate cyclase
APS58_RS02800	COG0831	urea catabolic process
APS58_RS02810	COG0832	Belongs to the urease beta subunit family
APS58_RS02815	COG0804	urea catabolic process
APS58_RS02825	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
APS58_RS02830	COG0830	nickel cation binding
APS58_RS02835	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APS58_RS02850	COG0464	growth
APS58_RS02875	COG2249	NAD(P)H dehydrogenase (quinone) activity
APS58_RS02880	COG2205	protein histidine kinase activity
APS58_RS02920	COG4968	Prepilin-type N-terminal cleavage methylation domain
APS58_RS02925	COG4968	Prepilin-type N-terminal cleavage methylation domain
APS58_RS02950	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APS58_RS02950	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APS58_RS02995	COG0784	Response regulator, receiver
APS58_RS02995	COG4191	Histidine kinase
APS58_RS03000	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APS58_RS03025	COG1595	DNA-templated transcription, initiation
APS58_RS03040	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APS58_RS03045	COG4221	oxidoreductase activity
APS58_RS03060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APS58_RS03065	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APS58_RS03085	COG1561	YicC-like family, N-terminal region
APS58_RS03090	COG0194	GDP metabolic process
APS58_RS03095	COG1758	RNA polymerase activity
APS58_RS03100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APS58_RS03130	COG3693	PFAM glycoside hydrolase, family 10
APS58_RS03135	COG2197	response regulator
APS58_RS03145	COG1420	regulation of RNA biosynthetic process
APS58_RS03150	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APS58_RS03155	COG0497	DNA recombination
APS58_RS03160	COG1660	Displays ATPase and GTPase activities
APS58_RS03165	COG1194	a g-specific adenine glycosylase
APS58_RS03175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
APS58_RS03190	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APS58_RS03200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APS58_RS03205	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
APS58_RS03210	COG0193	aminoacyl-tRNA hydrolase activity
APS58_RS03215	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APS58_RS03225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS58_RS03230	COG0444	Belongs to the ABC transporter superfamily
APS58_RS03235	COG4608	Belongs to the ABC transporter superfamily
APS58_RS03245	COG0747	negative chemotaxis
APS58_RS03275	COG1609	Transcriptional regulator
APS58_RS03305	COG0302	gtp cyclohydrolase
APS58_RS03310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APS58_RS03320	COG0745	RESPONSE REGULATOR receiver
APS58_RS03325	COG0494	nUDIX hydrolase
APS58_RS03335	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APS58_RS03355	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APS58_RS03370	COG2226	methyltransferase
APS58_RS03395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APS58_RS03400	COG1653	transport
APS58_RS03405	COG1175	transmembrane transport
APS58_RS03410	COG0395	ABC-type sugar transport system, permease component
APS58_RS03415	COG3842	ATPase activity
APS58_RS03425	COG0584	glycerophosphoryl diester phosphodiesterase
APS58_RS03430	COG1511	domain protein
APS58_RS03430	COG3264	Mechanosensitive ion channel
APS58_RS03470	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
APS58_RS03475	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APS58_RS03485	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APS58_RS03490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APS58_RS03495	COG1253	flavin adenine dinucleotide binding
APS58_RS03505	COG0442	prolyl-tRNA aminoacylation
APS58_RS03510	COG0494	nUDIX hydrolase
APS58_RS03520	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APS58_RS03525	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APS58_RS03530	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APS58_RS03535	COG0142	geranyltranstransferase activity
APS58_RS03545	COG1473	amidohydrolase
APS58_RS03555	COG0583	DNA-binding transcription factor activity
APS58_RS03575	COG0237	dephospho-CoA kinase activity
APS58_RS03580	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
APS58_RS03585	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
APS58_RS03590	COG0494	nUDIX hydrolase
APS58_RS03600	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
APS58_RS03605	COG0653	protein targeting
APS58_RS03610	COG0739	heme binding
APS58_RS03625	COG2969	positive regulation of protein catabolic process
APS58_RS03630	COG0625	glutathione transferase activity
APS58_RS03635	COG2857	Cytochrome c1
APS58_RS03640	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APS58_RS03645	COG0723	plastoquinol--plastocyanin reductase activity
APS58_RS03650	COG1970	mechanosensitive ion channel activity
APS58_RS03655	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APS58_RS03660	COG1136	(ABC) transporter
APS58_RS03670	COG4591	ABC-type transport system involved in lipoprotein release permease component
APS58_RS03680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APS58_RS03695	COG0738	Major facilitator superfamily
APS58_RS03700	COG0613	PHP domain protein
APS58_RS03705	COG0009	L-threonylcarbamoyladenylate synthase
APS58_RS03715	COG1994	Peptidase M50
APS58_RS03720	COG0180	Tryptophanyl-tRNA synthetase
APS58_RS03800	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APS58_RS03810	COG4774	siderophore transport
APS58_RS03815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APS58_RS03875	COG0443	Heat shock 70 kDa protein
APS58_RS03920	COG0038	chloride channel
APS58_RS03955	COG3209	COG3209 Rhs family protein
APS58_RS03965	COG0612	Peptidase, M16
APS58_RS03970	COG0765	amino acid transport
APS58_RS03975	COG0765	amino acid transport
APS58_RS03980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APS58_RS03995	COG0129	dihydroxy-acid dehydratase activity
APS58_RS04040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APS58_RS04045	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APS58_RS04050	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
APS58_RS04050	COG0517	IMP dehydrogenase activity
APS58_RS04050	COG0617	tRNA 3'-terminal CCA addition
APS58_RS04055	COG1253	flavin adenine dinucleotide binding
APS58_RS04060	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
APS58_RS04065	COG1047	Peptidyl-prolyl cis-trans
APS58_RS04070	COG2003	Belongs to the UPF0758 family
APS58_RS04090	COG1193	negative regulation of DNA recombination
APS58_RS04115	COG0737	Belongs to the 5'-nucleotidase family
APS58_RS04190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APS58_RS04205	COG0534	Mate efflux family protein
APS58_RS04210	COG0318	PFAM AMP-dependent synthetase and ligase
APS58_RS04235	COG2771	luxR family
APS58_RS04240	COG3916	Acyl-homoserine-lactone synthase
APS58_RS04250	COG1802	Transcriptional regulator
APS58_RS04260	COG0154	amidase activity
APS58_RS04305	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
APS58_RS04315	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
APS58_RS04320	COG0243	molybdopterin cofactor binding
APS58_RS04325	COG0840	transmembrane signaling receptor activity
APS58_RS04330	COG2223	nitrite transmembrane transporter activity
APS58_RS04335	COG0489	protein tyrosine kinase activity
APS58_RS04350	COG0028	Belongs to the TPP enzyme family
APS58_RS04355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APS58_RS04355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APS58_RS04385	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
APS58_RS04395	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APS58_RS04400	COG0156	8-amino-7-oxononanoate synthase activity
APS58_RS04405	COG0602	queuosine metabolic process
APS58_RS04410	COG0720	synthase
APS58_RS04435	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
APS58_RS04445	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
APS58_RS04450	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
APS58_RS04455	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APS58_RS04460	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
APS58_RS04470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APS58_RS04475	COG0588	phosphoglycerate mutase activity
APS58_RS04480	COG0793	Belongs to the peptidase S41A family
APS58_RS04485	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APS58_RS04495	COG2197	response regulator
APS58_RS04505	COG5487	UPF0391 membrane protein
APS58_RS04530	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APS58_RS04535	COG0742	ribosomal rna small subunit methyltransferase
APS58_RS04540	COG0612	Peptidase, M16
APS58_RS04545	COG0612	Peptidase, M16
APS58_RS04555	COG0179	Fumarylacetoacetate (FAA) hydrolase
APS58_RS04580	COG0840	transmembrane signaling receptor activity
APS58_RS04585	COG4977	sequence-specific DNA binding
APS58_RS04600	COG0534	Mate efflux family protein
APS58_RS04635	COG3842	ATPase activity
APS58_RS04645	COG0583	DNA-binding transcription factor activity
APS58_RS04655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APS58_RS04675	COG1999	signal sequence binding
APS58_RS04680	COG0109	protoheme IX farnesyltransferase activity
APS58_RS04685	COG1612	heme a metabolic process
APS58_RS04730	COG2226	methyltransferase
APS58_RS04735	COG1040	competence protein
APS58_RS04740	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
APS58_RS04745	COG0583	DNA-binding transcription factor activity
APS58_RS04760	COG1192	Involved in chromosome partitioning
APS58_RS04765	COG1280	lysine exporter protein (LysE YggA)
APS58_RS04775	COG4774	siderophore transport
APS58_RS04795	COG3038	cytochrome b561
APS58_RS04800	COG1846	Transcriptional regulator
APS58_RS04805	COG0840	transmembrane signaling receptor activity
APS58_RS04810	COG0477	Major facilitator Superfamily
APS58_RS04815	COG2010	Cytochrome c
APS58_RS04815	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APS58_RS04820	COG2080	2 iron, 2 sulfur cluster binding
APS58_RS04830	COG3473	Maleate cis-trans isomerase
APS58_RS04835	COG0596	Alpha beta hydrolase
APS58_RS04840	COG2309	aminopeptidase activity
APS58_RS04845	COG1335	isochorismatase
APS58_RS04850	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APS58_RS04850	COG2010	Cytochrome c
APS58_RS04870	COG3387	PFAM Glycoside hydrolase 15-related
APS58_RS04875	COG3181	Tripartite tricarboxylate transporter family receptor
APS58_RS04885	COG2031	fatty acid transporter
APS58_RS04905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APS58_RS04910	COG0183	Belongs to the thiolase family
APS58_RS04915	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
APS58_RS04925	COG1414	Transcriptional regulator
APS58_RS04955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APS58_RS05025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APS58_RS05040	COG0346	lactoylglutathione lyase activity
APS58_RS05070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APS58_RS05100	COG1132	(ABC) transporter
APS58_RS05105	COG0189	ligase activity
APS58_RS05105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APS58_RS05110	COG1181	Belongs to the D-alanine--D-alanine ligase family
APS58_RS05110	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APS58_RS05115	COG3045	CreA protein
APS58_RS05130	COG3145	DNA-N1-methyladenine dioxygenase activity
APS58_RS05145	COG0753	catalase activity
APS58_RS05150	COG0745	RESPONSE REGULATOR receiver
APS58_RS05155	COG0784	Response regulator, receiver
APS58_RS05155	COG5002	protein histidine kinase activity
APS58_RS05165	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
APS58_RS05200	COG0601	transmembrane transport
APS58_RS05205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS58_RS05215	COG0514	ATP-dependent DNA helicase (RecQ)
APS58_RS05235	COG3209	COG3209 Rhs family protein
APS58_RS05235	COG3209	COG3209 Rhs family protein
APS58_RS05255	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APS58_RS05260	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
APS58_RS05265	COG2080	2 iron, 2 sulfur cluster binding
APS58_RS05305	COG0737	Belongs to the 5'-nucleotidase family
APS58_RS05310	COG0583	DNA-binding transcription factor activity
APS58_RS05315	COG2855	membrane
APS58_RS05325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APS58_RS05350	COG2267	carboxylic ester hydrolase activity
APS58_RS05360	COG3002	Belongs to the UPF0753 family
APS58_RS05365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APS58_RS05410	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APS58_RS05435	COG0583	DNA-binding transcription factor activity
APS58_RS05440	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APS58_RS05450	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
APS58_RS05455	COG2814	Major facilitator Superfamily
APS58_RS05460	COG0316	Belongs to the HesB IscA family
APS58_RS05475	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
APS58_RS05480	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APS58_RS05485	COG0515	serine threonine protein kinase
APS58_RS05485	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APS58_RS05490	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
APS58_RS05495	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APS58_RS05520	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
APS58_RS05530	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
APS58_RS05540	COG2076	Multidrug Resistance protein
APS58_RS05570	COG1126	abc transporter atp-binding protein
APS58_RS05575	COG0765	amino acid transport
APS58_RS05580	COG0765	amino acid transport
APS58_RS05585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APS58_RS05595	COG0583	DNA-binding transcription factor activity
APS58_RS05600	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
APS58_RS05605	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
APS58_RS05605	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APS58_RS05610	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APS58_RS05615	COG5265	(ABC) transporter
APS58_RS05630	COG3181	Tripartite tricarboxylate transporter family receptor
APS58_RS05635	COG1024	Enoyl-CoA hydratase
APS58_RS05645	COG0183	Belongs to the thiolase family
APS58_RS05665	COG1960	acyl-CoA dehydrogenase activity
APS58_RS05675	COG1309	transcriptional regulator
APS58_RS05685	COG0745	RESPONSE REGULATOR receiver
APS58_RS05690	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APS58_RS05730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APS58_RS05745	COG1450	Type ii and iii secretion system protein
APS58_RS05775	COG2165	general secretion pathway protein
APS58_RS05780	COG4970	Tfp pilus assembly protein FimT
APS58_RS05785	COG2165	general secretion pathway protein
APS58_RS05790	COG1459	type II secretion system
APS58_RS05795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APS58_RS05835	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
APS58_RS05840	COG1652	LysM domain
APS58_RS05860	COG0204	Acyl-transferase
APS58_RS05865	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APS58_RS05875	COG0751	glycine-tRNA ligase activity
APS58_RS05880	COG0752	glycyl-tRNA synthetase alpha subunit
APS58_RS05885	COG3258	Cytochrome c
APS58_RS05895	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APS58_RS05910	COG0815	Transfers the fatty acyl group on membrane lipoproteins
APS58_RS05915	COG4535	Mg2 and Co2 transporter CorC
APS58_RS05930	COG1522	sequence-specific DNA binding
APS58_RS05935	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
APS58_RS05955	COG3186	Phenylalanine-4-hydroxylase
APS58_RS05980	COG1129	ABC transporter
APS58_RS05985	COG1172	Belongs to the binding-protein-dependent transport system permease family
APS58_RS05995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APS58_RS06000	COG1869	D-ribose catabolic process
APS58_RS06015	COG1196	nuclear chromosome segregation
APS58_RS06015	COG0739	heme binding
APS58_RS06015	COG0741	lytic transglycosylase activity
APS58_RS06020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APS58_RS06045	COG0617	tRNA 3'-terminal CCA addition
APS58_RS06060	COG3387	PFAM Glycoside hydrolase 15-related
APS58_RS06065	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
APS58_RS06085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APS58_RS06100	COG1028	Short-chain dehydrogenase reductase Sdr
APS58_RS06110	COG2879	small protein
APS58_RS06115	COG1966	Carbon starvation protein
APS58_RS06120	COG2197	response regulator
APS58_RS06130	COG0037	tRNA processing
APS58_RS06165	COG2255	four-way junction helicase activity
APS58_RS06180	COG0632	four-way junction helicase activity
APS58_RS06185	COG1702	phosphate starvation-inducible protein PhoH
APS58_RS06205	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APS58_RS06210	COG1490	D-aminoacyl-tRNA deacylase activity
APS58_RS06215	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
APS58_RS06220	COG0513	Belongs to the DEAD box helicase family
APS58_RS06225	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APS58_RS06230	COG3706	GGDEF domain
APS58_RS06245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APS58_RS06245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APS58_RS06255	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APS58_RS06255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APS58_RS06275	COG0443	Heat shock 70 kDa protein
APS58_RS06285	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
APS58_RS06290	COG1131	(ABC) transporter
APS58_RS06295	COG0842	Transport permease protein
APS58_RS06300	COG1250	3-hydroxyacyl-CoA dehydrogenase
APS58_RS06310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APS58_RS06330	COG0179	Fumarylacetoacetate (FAA) hydrolase
APS58_RS06335	COG3971	2-oxopent-4-enoate hydratase activity
APS58_RS06345	COG1846	Transcriptional regulator
APS58_RS06350	COG1764	response to oxidative stress
APS58_RS06360	COG0515	serine threonine protein kinase
APS58_RS06360	COG2815	serine threonine protein kinase
APS58_RS06405	COG3209	COG3209 Rhs family protein
APS58_RS06445	COG0326	Molecular chaperone. Has ATPase activity
APS58_RS06475	COG0840	transmembrane signaling receptor activity
APS58_RS06495	COG3568	Endonuclease Exonuclease Phosphatase
APS58_RS06500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APS58_RS06505	COG0392	lysyltransferase activity
APS58_RS06510	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
APS58_RS06520	COG0840	transmembrane signaling receptor activity
APS58_RS06555	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APS58_RS06560	COG1024	Enoyl-CoA hydratase
APS58_RS06565	COG1960	acyl-CoA dehydrogenase activity
APS58_RS06570	COG1960	acyl-CoA dehydrogenase activity
APS58_RS06575	COG1250	3-hydroxyacyl-CoA dehydrogenase
APS58_RS06575	COG1024	Enoyl-CoA hydratase
APS58_RS06580	COG0583	DNA-binding transcription factor activity
APS58_RS06585	COG0501	Belongs to the peptidase M48B family
APS58_RS06600	COG0418	dihydroorotase activity
APS58_RS06605	COG2205	protein histidine kinase activity
APS58_RS06610	COG0745	RESPONSE REGULATOR receiver
APS58_RS06625	COG0577	efflux transmembrane transporter activity
APS58_RS06625	COG1136	(ABC) transporter
APS58_RS06655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APS58_RS06705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APS58_RS06720	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APS58_RS06755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APS58_RS06770	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
APS58_RS06775	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
APS58_RS06780	COG0318	PFAM AMP-dependent synthetase and ligase
APS58_RS06800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APS58_RS06805	COG2205	protein histidine kinase activity
APS58_RS06805	COG2198	Histidine kinase
APS58_RS06805	COG0784	Response regulator, receiver
APS58_RS06810	COG3012	SEC-C Motif Domain Protein
APS58_RS06825	COG1960	acyl-CoA dehydrogenase activity
APS58_RS06840	COG0183	Belongs to the thiolase family
APS58_RS06845	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
APS58_RS06850	COG0288	reversible hydration of carbon dioxide
APS58_RS06855	COG1960	acyl-CoA dehydrogenase activity
APS58_RS06865	COG0789	Transcriptional regulator
APS58_RS06895	COG0488	(ABC) transporter
APS58_RS06900	COG2201	protein-glutamate methylesterase activity
APS58_RS06905	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
APS58_RS06910	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
APS58_RS06915	COG0835	chemotaxis
APS58_RS06920	COG0643	Histidine kinase
APS58_RS06920	COG2198	Histidine kinase
APS58_RS06925	COG0745	RESPONSE REGULATOR receiver
APS58_RS06935	COG3851	Histidine kinase
APS58_RS06940	COG2197	response regulator
APS58_RS06950	COG1987	bacterial-type flagellum assembly
APS58_RS06965	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APS58_RS06975	COG1580	Controls the rotational direction of flagella during chemotaxis
APS58_RS07005	COG1766	The M ring may be actively involved in energy transduction
APS58_RS07010	COG1677	Flagellar hook-basal body complex protein FliE
APS58_RS07045	COG4106	trans-aconitate 2-methyltransferase activity
APS58_RS07055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APS58_RS07060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APS58_RS07065	COG0438	transferase activity, transferring glycosyl groups
APS58_RS07065	COG1216	Glycosyl transferase, family 2
APS58_RS07070	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
APS58_RS07075	COG1360	Flagellar Motor Protein
APS58_RS07080	COG0745	RESPONSE REGULATOR receiver
APS58_RS07085	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
APS58_RS07090	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APS58_RS07130	COG1815	bacterial-type flagellum-dependent cell motility
APS58_RS07135	COG1558	bacterial-type flagellum-dependent cell motility
APS58_RS07140	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
APS58_RS07150	COG4787	bacterial-type flagellum-dependent cell motility
APS58_RS07160	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
APS58_RS07170	COG1706	bacterial-type flagellum-dependent cell motility
APS58_RS07175	COG3951	Flagellar rod assembly protein muramidase FlgJ
APS58_RS07175	COG1705	Flagellar rod assembly protein muramidase FlgJ
APS58_RS07185	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APS58_RS07205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APS58_RS07215	COG0697	spore germination
APS58_RS07220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APS58_RS07225	COG0625	glutathione transferase activity
APS58_RS07230	COG0384	phenazine biosynthesis protein PhzF
APS58_RS07325	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APS58_RS07355	COG0861	Integral membrane protein TerC family
APS58_RS07360	COG0583	DNA-binding transcription factor activity
APS58_RS07380	COG3119	arylsulfatase activity
APS58_RS07395	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APS58_RS07405	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APS58_RS07425	COG0210	DNA helicase
APS58_RS07450	COG0343	queuine tRNA-ribosyltransferase activity
APS58_RS07485	COG1028	Short-chain dehydrogenase reductase Sdr
APS58_RS07515	COG1522	sequence-specific DNA binding
APS58_RS07520	COG2515	1-aminocyclopropane-1-carboxylate deaminase
APS58_RS07530	COG0840	transmembrane signaling receptor activity
APS58_RS07570	COG3181	Tripartite tricarboxylate transporter family receptor
APS58_RS07575	COG2072	flavoprotein involved in K transport
APS58_RS07585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APS58_RS07605	COG2365	Tyrosine phosphatase family
APS58_RS07610	COG1028	Short-chain dehydrogenase reductase Sdr
APS58_RS07620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APS58_RS07625	COG1116	anion transmembrane transporter activity
APS58_RS07640	COG3046	protein related to deoxyribodipyrimidine photolyase
APS58_RS07665	COG2032	superoxide dismutase activity
APS58_RS07680	COG2204	response regulator
APS58_RS07685	COG5000	phosphorelay sensor kinase activity
APS58_RS07695	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APS58_RS07695	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APS58_RS07705	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APS58_RS07710	COG0085	RNA polymerase activity
APS58_RS07715	COG0222	ribosome binding
APS58_RS07720	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APS58_RS07725	COG0081	regulation of translation
APS58_RS07730	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APS58_RS07740	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APS58_RS07750	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APS58_RS07795	COG0189	ligase activity
APS58_RS07800	COG3135	benzoate transporter
APS58_RS07805	COG3158	transport of potassium into the cell
APS58_RS07820	COG0569	domain protein
APS58_RS07825	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APS58_RS07845	COG0495	leucyl-tRNA aminoacylation
APS58_RS07855	COG5001	Diguanylate cyclase
APS58_RS07855	COG3300	MHYT domain
APS58_RS07870	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APS58_RS07875	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APS58_RS07880	COG0735	belongs to the Fur family
APS58_RS07885	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
APS58_RS07895	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APS58_RS07900	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
APS58_RS07910	COG3118	belongs to the thioredoxin family
APS58_RS07915	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APS58_RS07920	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APS58_RS07925	COG0009	L-threonylcarbamoyladenylate synthase
APS58_RS07950	COG1214	PFAM Peptidase M22, glycoprotease
APS58_RS07965	COG0598	Magnesium transport protein CorA
APS58_RS07975	COG0318	PFAM AMP-dependent synthetase and ligase
APS58_RS08010	COG0469	pyruvate kinase activity
APS58_RS08015	COG0006	proline dipeptidase activity
APS58_RS08020	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
APS58_RS08030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APS58_RS08050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APS58_RS08060	COG0583	DNA-binding transcription factor activity
APS58_RS08095	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
APS58_RS08150	COG0668	transmembrane transport
APS58_RS08165	COG1028	Short-chain dehydrogenase reductase Sdr
APS58_RS08180	COG2764	glyoxalase bleomycin resistance protein dioxygenase
APS58_RS08235	COG1714	RDD family
APS58_RS08275	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
APS58_RS08275	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
APS58_RS08305	COG0583	DNA-binding transcription factor activity
APS58_RS08315	COG0642	Histidine kinase
APS58_RS08330	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APS58_RS08335	COG2137	regulation of response to DNA damage stimulus
APS58_RS08345	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APS58_RS08350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APS58_RS08355	COG1862	Preprotein translocase
APS58_RS08365	COG1522	sequence-specific DNA binding
APS58_RS08375	COG2814	Major facilitator Superfamily
APS58_RS08395	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
APS58_RS08425	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
APS58_RS08430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APS58_RS08445	COG1309	transcriptional regulator
APS58_RS08455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APS58_RS08480	COG0625	glutathione transferase activity
APS58_RS08505	COG0861	Integral membrane protein TerC family
APS58_RS08515	COG1950	PFAM Membrane protein of
APS58_RS08520	COG4783	chaperone-mediated protein folding
APS58_RS08525	COG0315	cyclic pyranopterin monophosphate synthase activity
APS58_RS08535	COG3307	-O-antigen
APS58_RS08545	COG1716	ATPase activity
APS58_RS08550	COG0631	protein serine/threonine phosphatase activity
APS58_RS08555	COG0861	Integral membrane protein TerC family
APS58_RS08560	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APS58_RS08565	COG0045	succinate-CoA ligase (ADP-forming) activity
APS58_RS08570	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APS58_RS08575	COG0758	DNA mediated transformation
APS58_RS08585	COG0242	peptide deformylase activity
APS58_RS08595	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APS58_RS08610	COG0126	phosphoglycerate kinase activity
APS58_RS08620	COG0697	spore germination
APS58_RS08625	COG0284	orotidine-5'-phosphate decarboxylase activity
APS58_RS08630	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
APS58_RS08660	COG0840	transmembrane signaling receptor activity
APS58_RS08700	COG2814	Major facilitator Superfamily
APS58_RS08710	COG0629	single-stranded DNA binding
APS58_RS08735	COG0640	Transcriptional regulator
APS58_RS08765	COG1620	l-lactate permease
APS58_RS08770	COG0482	sulfurtransferase activity
APS58_RS08775	COG0494	nUDIX hydrolase
APS58_RS08805	COG0307	riboflavin synthase, alpha
APS58_RS08830	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
APS58_RS08835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
APS58_RS08895	COG1802	Transcriptional regulator
APS58_RS08945	COG0280	phosphate acetyltransferase
APS58_RS08945	COG0281	malic enzyme
APS58_RS08960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APS58_RS08965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APS58_RS08970	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
APS58_RS08980	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APS58_RS08995	COG1196	nuclear chromosome segregation
APS58_RS09000	COG2814	Major facilitator Superfamily
APS58_RS09010	COG2207	Transcriptional regulator
APS58_RS09015	COG1113	amino acid transport
APS58_RS09020	COG4303	Ethanolamine ammonia lyase large subunit
APS58_RS09025	COG4302	ethanolamine ammonia-lyase activity
APS58_RS09035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APS58_RS09040	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APS58_RS09045	COG2119	membrane
APS58_RS09050	COG0724	RNA recognition motif
APS58_RS09055	COG0724	RNA recognition motif
APS58_RS09060	COG0300	oxidoreductase activity
APS58_RS09070	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
APS58_RS09085	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APS58_RS09105	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APS58_RS09115	COG0706	membrane insertase activity
APS58_RS09120	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
APS58_RS09125	COG0594	ribonuclease P activity
APS58_RS09130	COG0230	Belongs to the bacterial ribosomal protein bL34 family
APS58_RS09135	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APS58_RS09185	COG1764	response to oxidative stress
APS58_RS09205	COG1199	ATP-dependent helicase activity
APS58_RS09220	COG2176	DNA-directed DNA polymerase activity
APS58_RS09235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APS58_RS09240	COG0791	NLP P60 protein
APS58_RS09245	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APS58_RS09265	COG2974	May be involved in recombination
APS58_RS09270	COG2715	membrane protein required for spore maturation
APS58_RS09295	COG0183	Belongs to the thiolase family
APS58_RS09300	COG0789	Transcriptional regulator
APS58_RS09310	COG2217	Heavy metal translocating P-type atpase
APS58_RS09345	COG0745	RESPONSE REGULATOR receiver
APS58_RS09350	COG0642	Histidine kinase
APS58_RS09370	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
APS58_RS09375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APS58_RS09395	COG0445	tRNA wobble uridine modification
APS58_RS09400	COG0357	Ribosomal RNA small subunit methyltransferase G
APS58_RS09405	COG1280	lysine exporter protein (LysE YggA)
APS58_RS09410	COG1192	Involved in chromosome partitioning
APS58_RS09435	COG0493	'glutamate synthase
APS58_RS09455	COG0277	FAD linked oxidase domain protein
APS58_RS09460	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
APS58_RS09460	COG0546	phosphoglycolate phosphatase activity
APS58_RS09475	COG2272	Belongs to the type-B carboxylesterase lipase family
APS58_RS09495	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
APS58_RS09530	COG3411	Ferredoxin
APS58_RS09545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APS58_RS09635	COG0277	FAD linked oxidase domain protein
APS58_RS09650	COG2096	Adenosyltransferase
APS58_RS09655	COG2050	protein possibly involved in aromatic compounds catabolism
APS58_RS09670	COG2233	PERMEase
APS58_RS09690	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APS58_RS09720	COG1116	anion transmembrane transporter activity
APS58_RS09725	COG0395	ABC-type sugar transport system, permease component
APS58_RS09745	COG1414	Transcriptional regulator
APS58_RS09750	COG0501	Belongs to the peptidase M48B family
APS58_RS09760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APS58_RS09775	COG2423	ornithine cyclodeaminase activity
APS58_RS09785	COG1183	phosphatidylcholine synthase activity
APS58_RS09795	COG0850	regulation of cytokinetic process
APS58_RS09800	COG2894	cell division
APS58_RS09805	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
APS58_RS09810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APS58_RS09825	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
APS58_RS09830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APS58_RS09865	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
APS58_RS09870	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
APS58_RS09875	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
APS58_RS09880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APS58_RS09890	COG1960	acyl-CoA dehydrogenase activity
APS58_RS09910	COG0625	glutathione transferase activity
APS58_RS09915	COG2271	Major facilitator Superfamily
APS58_RS09925	COG2423	ornithine cyclodeaminase activity
APS58_RS09955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APS58_RS10010	COG0840	transmembrane signaling receptor activity
APS58_RS10045	COG0583	DNA-binding transcription factor activity
APS58_RS10060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APS58_RS10065	COG3181	Tripartite tricarboxylate transporter family receptor
APS58_RS10105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APS58_RS10115	COG2326	polyphosphate kinase activity
APS58_RS10155	COG0583	DNA-binding transcription factor activity
APS58_RS10200	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
APS58_RS10205	COG1126	abc transporter atp-binding protein
APS58_RS10210	COG0765	amino acid transport
APS58_RS10215	COG0765	amino acid transport
APS58_RS10240	COG0646	methionine synthase
APS58_RS10240	COG1410	methionine synthase
APS58_RS10300	COG0583	DNA-binding transcription factor activity
APS58_RS10310	COG0840	transmembrane signaling receptor activity
APS58_RS10315	COG3181	Tripartite tricarboxylate transporter family receptor
APS58_RS10320	COG4191	Histidine kinase
APS58_RS10330	COG0606	chelatase, subunit chli
APS58_RS10340	COG0347	Belongs to the P(II) protein family
APS58_RS10345	COG0004	ammonium transporteR
APS58_RS10390	COG0277	FAD linked oxidase domain protein
APS58_RS10400	COG0247	lactate metabolic process
APS58_RS10430	COG0386	Belongs to the glutathione peroxidase family
APS58_RS10440	COG0477	Major facilitator Superfamily
APS58_RS10445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APS58_RS10455	COG0747	negative chemotaxis
APS58_RS10475	COG0625	glutathione transferase activity
APS58_RS10480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
APS58_RS10525	COG1215	transferase activity, transferring glycosyl groups
APS58_RS10545	COG0477	Major facilitator Superfamily
APS58_RS10560	COG0745	RESPONSE REGULATOR receiver
APS58_RS10565	COG2211	Major facilitator Superfamily
APS58_RS10585	COG0501	Belongs to the peptidase M48B family
APS58_RS10590	COG0471	metal ion transport
APS58_RS10595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APS58_RS10615	COG0583	DNA-binding transcription factor activity
APS58_RS10620	COG2814	Major facilitator Superfamily
APS58_RS10630	COG0708	Exodeoxyribonuclease III
APS58_RS10635	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APS58_RS10645	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APS58_RS10650	COG0154	amidase activity
APS58_RS10655	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APS58_RS10660	COG1077	Cell shape determining protein MreB Mrl
APS58_RS10670	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
APS58_RS10675	COG0768	penicillin binding
APS58_RS10690	COG0765	amino acid transport
APS58_RS10695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APS58_RS10700	COG1760	l-serine dehydratase
APS58_RS10720	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APS58_RS10725	COG1127	ABC transporter
APS58_RS10750	COG3237	CsbD-like
APS58_RS10770	COG4452	Inner membrane protein CreD
APS58_RS10775	COG2205	protein histidine kinase activity
APS58_RS10780	COG0745	RESPONSE REGULATOR receiver
APS58_RS10785	COG2095	MarC family integral membrane protein
APS58_RS10790	COG1028	Short-chain dehydrogenase reductase Sdr
APS58_RS10795	COG0412	Dienelactone hydrolase
APS58_RS10805	COG1566	PFAM secretion protein HlyD family protein
APS58_RS10815	COG1846	Transcriptional regulator
APS58_RS10820	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APS58_RS10820	COG0519	Catalyzes the synthesis of GMP from XMP
APS58_RS10825	COG0598	Magnesium transport protein CorA
APS58_RS10835	COG1981	membrane
APS58_RS10850	COG2945	thiolester hydrolase activity
APS58_RS10855	COG1686	Belongs to the peptidase S11 family
APS58_RS10860	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APS58_RS10865	COG0049	tRNA binding
APS58_RS10870	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APS58_RS10875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APS58_RS10880	COG0051	transcription antitermination factor activity, RNA binding
APS58_RS10885	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APS58_RS10890	COG0088	Forms part of the polypeptide exit tunnel
APS58_RS10895	COG0089	rRNA binding
APS58_RS10900	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APS58_RS10905	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APS58_RS10910	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APS58_RS10915	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APS58_RS10920	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APS58_RS10925	COG0255	Belongs to the universal ribosomal protein uL29 family
APS58_RS10930	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APS58_RS10935	COG0678	peroxiredoxin activity
APS58_RS10945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APS58_RS10960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APS58_RS10965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APS58_RS10980	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
APS58_RS10985	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
APS58_RS10990	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
APS58_RS10995	COG2205	protein histidine kinase activity
APS58_RS11000	COG0745	RESPONSE REGULATOR receiver
APS58_RS11015	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APS58_RS11020	COG0321	lipoyl(octanoyl) transferase activity
APS58_RS11025	COG2921	Belongs to the UPF0250 family
APS58_RS11035	COG0356	it plays a direct role in the translocation of protons across the membrane
APS58_RS11045	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APS58_RS11050	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APS58_RS11055	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APS58_RS11060	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APS58_RS11065	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APS58_RS11070	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APS58_RS11080	COG1793	dna ligase
APS58_RS11085	COG1201	RNA secondary structure unwinding
APS58_RS11135	COG3245	cytochrome
APS58_RS11150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APS58_RS11155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APS58_RS11235	COG0121	glutamine amidotransferase
APS58_RS11240	COG2814	Major facilitator Superfamily
APS58_RS11245	COG1942	4-Oxalocrotonate Tautomerase
APS58_RS11260	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
APS58_RS11290	COG0018	arginyl-trna synthetase
APS58_RS11300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APS58_RS11310	COG1137	ATPase activity
APS58_RS11315	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
APS58_RS11320	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
APS58_RS11340	COG4178	(ABC) transporter
APS58_RS11350	COG0653	protein targeting
APS58_RS11355	COG0659	secondary active sulfate transmembrane transporter activity
APS58_RS11370	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
APS58_RS11390	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
APS58_RS11405	COG2967	ApaG domain
APS58_RS11410	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APS58_RS11420	COG0546	phosphoglycolate phosphatase activity
APS58_RS11440	COG2207	Transcriptional regulator
APS58_RS11460	COG4794	Type iii secretion
APS58_RS11465	COG4790	Type iii secretion
APS58_RS11480	COG4789	Type iii secretion
APS58_RS11485	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APS58_RS11605	COG0500	methyltransferase
APS58_RS11610	COG1196	nuclear chromosome segregation
APS58_RS11610	COG0741	lytic transglycosylase activity
APS58_RS11610	COG0739	heme binding
APS58_RS11635	COG0512	Glutamine amidotransferase of anthranilate synthase
APS58_RS11640	COG1280	lysine exporter protein (LysE YggA)
APS58_RS11645	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APS58_RS11650	COG0134	indole-3-glycerol-phosphate synthase activity
APS58_RS11655	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APS58_RS11695	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APS58_RS11705	COG0783	Belongs to the Dps family
APS58_RS11710	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
APS58_RS11725	COG0463	Glycosyl transferase, family 2
APS58_RS11740	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APS58_RS11750	COG3842	ATPase activity
APS58_RS11755	COG3842	ATPase activity
APS58_RS11765	COG0395	ABC-type sugar transport system, permease component
APS58_RS11785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APS58_RS11790	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APS58_RS11795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APS58_RS11800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APS58_RS11805	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APS58_RS11810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APS58_RS11815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APS58_RS11820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APS58_RS11825	COG1841	ribosomal large subunit assembly
APS58_RS11830	COG0200	Binds to the 23S rRNA
APS58_RS11835	COG0201	protein transport
APS58_RS11840	COG0257	Belongs to the bacterial ribosomal protein bL36 family
APS58_RS11845	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APS58_RS11850	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APS58_RS11855	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APS58_RS11860	COG0202	RNA polymerase activity
APS58_RS11865	COG0203	ribosomal protein L17
APS58_RS11875	COG0443	Heat shock 70 kDa protein
APS58_RS11880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APS58_RS11885	COG0792	nuclease activity
APS58_RS11890	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
APS58_RS11895	COG2823	Periplasmic or secreted lipoprotein
APS58_RS11900	COG2084	Dehydrogenase
APS58_RS11910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APS58_RS11935	COG2733	membrane
APS58_RS11955	COG0277	FAD linked oxidase domain protein
APS58_RS11965	COG0583	DNA-binding transcription factor activity
APS58_RS11985	COG1285	pathogenesis
APS58_RS11995	COG3850	Histidine kinase
APS58_RS12000	COG2197	response regulator
APS58_RS12015	COG4771	TonB-dependent receptor
APS58_RS12030	COG2223	nitrite transmembrane transporter activity
APS58_RS12035	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
APS58_RS12040	COG1140	nitrate reductase beta subunit
APS58_RS12045	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
APS58_RS12050	COG2181	nitrate reductase activity
APS58_RS12055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APS58_RS12060	COG0288	reversible hydration of carbon dioxide
APS58_RS12075	COG3945	hemerythrin HHE cation binding domain
APS58_RS12090	COG0477	Major facilitator Superfamily
APS58_RS12135	COG1272	protein, Hemolysin III
APS58_RS12195	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APS58_RS12200	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
APS58_RS12210	COG0129	dihydroxy-acid dehydratase activity
APS58_RS12215	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APS58_RS12225	COG0583	DNA-binding transcription factor activity
APS58_RS12230	COG1741	Belongs to the pirin family
APS58_RS12235	COG1335	isochorismatase
APS58_RS12275	COG0243	molybdopterin cofactor binding
APS58_RS12290	COG1473	amidohydrolase
APS58_RS12300	COG0840	transmembrane signaling receptor activity
APS58_RS12315	COG0519	Catalyzes the synthesis of GMP from XMP
APS58_RS12320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APS58_RS12380	COG3266	domain, Protein
APS58_RS12395	COG4269	membrane
APS58_RS12430	COG0625	glutathione transferase activity
APS58_RS12435	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
APS58_RS12445	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
APS58_RS12450	COG1649	PFAM Uncharacterised BCR, COG1649
APS58_RS12470	COG3447	MASE1 domain protein
APS58_RS12470	COG5002	protein histidine kinase activity
APS58_RS12470	COG5001	Diguanylate cyclase
APS58_RS12475	COG0523	cobalamin synthesis protein
APS58_RS12490	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
APS58_RS12495	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
APS58_RS12500	COG2001	Belongs to the MraZ family
APS58_RS12505	COG0275	rRNA processing
APS58_RS12510	COG3116	cell division
APS58_RS12520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APS58_RS12525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APS58_RS12530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APS58_RS12535	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APS58_RS12540	COG0772	Belongs to the SEDS family
APS58_RS12545	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APS58_RS12550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APS58_RS12555	COG1181	Belongs to the D-alanine--D-alanine ligase family
APS58_RS12560	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
APS58_RS12570	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APS58_RS12575	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
APS58_RS12580	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
APS58_RS12585	COG0840	transmembrane signaling receptor activity
APS58_RS12600	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
APS58_RS12605	COG0575	Belongs to the CDS family
APS58_RS12630	COG1414	Transcriptional regulator
APS58_RS12635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APS58_RS12640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APS58_RS12650	COG0557	exoribonuclease II activity
APS58_RS12660	COG3150	esterase
APS58_RS12665	COG0772	Belongs to the SEDS family
APS58_RS12670	COG0154	amidase activity
APS58_RS12675	COG0312	modulator of DNA gyrase
APS58_RS12685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APS58_RS12695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APS58_RS12705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APS58_RS12710	COG0511	ligase activity, forming carbon-carbon bonds
APS58_RS12715	COG0439	Biotin carboxylase
APS58_RS12720	COG2264	protein methyltransferase activity
APS58_RS12730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APS58_RS12740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APS58_RS12775	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APS58_RS12785	COG2204	response regulator
APS58_RS12795	COG2205	protein histidine kinase activity
APS58_RS12800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APS58_RS12825	COG0431	NADPH-dependent FMN reductase
APS58_RS12830	COG3829	transcription factor binding
APS58_RS12835	COG1024	Enoyl-CoA hydratase
APS58_RS12850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APS58_RS12855	COG3217	Mosc domain protein beta barrel domain protein
APS58_RS12855	COG0633	Ferredoxin
APS58_RS12860	COG0012	GTP binding
APS58_RS12875	COG0517	IMP dehydrogenase activity
APS58_RS12875	COG1125	glycine betaine transport
APS58_RS12885	COG1238	metal cluster binding
APS58_RS12895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APS58_RS12900	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
APS58_RS12905	COG0138	bifunctional purine biosynthesis protein purh
APS58_RS12915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APS58_RS12920	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
APS58_RS12920	COG0352	thiamine-phosphate diphosphorylase activity
APS58_RS12920	COG0351	phosphomethylpyrimidine kinase
APS58_RS12925	COG1773	rubredoxin
APS58_RS12940	COG0835	chemotaxis
APS58_RS12945	COG0840	transmembrane signaling receptor activity
APS58_RS12950	COG2198	Histidine kinase
APS58_RS12950	COG0643	Histidine kinase
APS58_RS12955	COG0415	Belongs to the DNA photolyase family
APS58_RS12960	COG1678	Uncharacterized ACR, COG1678
APS58_RS12965	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APS58_RS12970	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
APS58_RS12975	COG0540	Belongs to the ATCase OTCase family
APS58_RS12995	COG3842	ATPase activity
APS58_RS13000	COG1178	ABC-type Fe3 transport system permease component
APS58_RS13050	COG4970	Tfp pilus assembly protein FimT
APS58_RS13070	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
APS58_RS13075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APS58_RS13080	COG1765	OsmC-like protein
APS58_RS13085	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
APS58_RS13105	COG1473	amidohydrolase
APS58_RS13110	COG0747	negative chemotaxis
APS58_RS13115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS58_RS13120	COG0444	Belongs to the ABC transporter superfamily
APS58_RS13125	COG4608	Belongs to the ABC transporter superfamily
APS58_RS13130	COG0840	transmembrane signaling receptor activity
APS58_RS13145	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APS58_RS13155	COG0166	Belongs to the GPI family
APS58_RS13160	COG0459	protein refolding
APS58_RS13165	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APS58_RS13180	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
APS58_RS13215	COG2226	methyltransferase
APS58_RS13220	COG0438	transferase activity, transferring glycosyl groups
APS58_RS13230	COG0367	asparagine synthase
APS58_RS13235	COG0438	transferase activity, transferring glycosyl groups
APS58_RS13240	COG0367	asparagine synthase
APS58_RS13260	COG1216	Glycosyl transferase, family 2
APS58_RS13270	COG1309	transcriptional regulator
APS58_RS13275	COG0493	'glutamate synthase
APS58_RS13285	COG1953	Uracil, thiamine, allantoin
APS58_RS13320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APS58_RS13320	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
APS58_RS13325	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
APS58_RS13340	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APS58_RS13350	COG1560	Kdo2-lipid A biosynthetic process
APS58_RS13360	COG0218	Necessary for normal cell division and for the maintenance of normal septation
APS58_RS13370	COG1333	cytochrome c biogenesis protein
APS58_RS13375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APS58_RS13380	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APS58_RS13385	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
APS58_RS13415	COG1965	Belongs to the frataxin family
APS58_RS13455	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APS58_RS13460	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APS58_RS13465	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APS58_RS13485	COG0069	glutamate synthase activity
APS58_RS13485	COG0070	glutamate synthase
APS58_RS13485	COG0067	glutamate synthase
APS58_RS13495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APS58_RS13500	COG0765	amino acid transport
APS58_RS13505	COG1126	abc transporter atp-binding protein
APS58_RS13510	COG1127	ABC transporter
APS58_RS13515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APS58_RS13520	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APS58_RS13525	COG2853	Lipoprotein
APS58_RS13545	COG1131	(ABC) transporter
APS58_RS13550	COG0842	Transport permease protein
APS58_RS13555	COG5007	Belongs to the BolA IbaG family
APS58_RS13560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APS58_RS13565	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APS58_RS13570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APS58_RS13600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APS58_RS13605	COG0131	Imidazoleglycerol-phosphate dehydratase
APS58_RS13615	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APS58_RS13635	COG0438	transferase activity, transferring glycosyl groups
APS58_RS13665	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APS58_RS13670	COG1301	dicarboxylic acid transport
APS58_RS13680	COG0107	imidazoleglycerol-phosphate synthase activity
APS58_RS13685	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APS58_RS13690	COG0140	phosphoribosyl-ATP diphosphatase activity
APS58_RS13705	COG0537	adenosine 5'-monophosphoramidase activity
APS58_RS13710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APS58_RS13715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APS58_RS13720	COG0805	protein transport
APS58_RS13755	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
APS58_RS13775	COG0714	Associated with various cellular activities
APS58_RS13780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APS58_RS13785	COG0084	hydrolase, TatD family'
APS58_RS13795	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
APS58_RS13800	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APS58_RS13850	COG1028	Short-chain dehydrogenase reductase Sdr
APS58_RS13855	COG0840	transmembrane signaling receptor activity
APS58_RS13860	COG0829	nickel cation binding
APS58_RS13880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APS58_RS13905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APS58_RS13910	COG1116	anion transmembrane transporter activity
APS58_RS13925	COG0281	malic enzyme
APS58_RS13925	COG0280	phosphate acetyltransferase
APS58_RS13945	COG1953	Uracil, thiamine, allantoin
APS58_RS13950	COG2186	Transcriptional regulator
APS58_RS13955	COG0840	transmembrane signaling receptor activity
APS58_RS13960	COG1301	dicarboxylic acid transport
APS58_RS13990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APS58_RS14005	COG2186	Transcriptional regulator
APS58_RS14015	COG0405	Gamma-glutamyltransferase
APS58_RS14055	COG0251	oxidation-reduction process
APS58_RS14075	COG5002	protein histidine kinase activity
APS58_RS14075	COG3447	MASE1 domain protein
APS58_RS14075	COG5001	Diguanylate cyclase
APS58_RS14090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APS58_RS14110	COG3845	ABC transporter
APS58_RS14115	COG4603	Belongs to the binding-protein-dependent transport system permease family
APS58_RS14140	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
APS58_RS14150	COG2366	antibiotic biosynthetic process
APS58_RS14155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APS58_RS14170	COG0717	Belongs to the dCTP deaminase family
APS58_RS14185	COG2321	neutral zinc metallopeptidase
APS58_RS14190	COG0513	Belongs to the DEAD box helicase family
APS58_RS14195	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APS58_RS14200	COG2916	Histone family protein nucleoid-structuring protein H-NS
APS58_RS14205	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APS58_RS14235	COG3483	tryptophan 2,3-dioxygenase activity
APS58_RS14245	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
APS58_RS14250	COG1522	sequence-specific DNA binding
APS58_RS14255	COG0727	PFAM Uncharacterised protein family (UPF0153)
APS58_RS14280	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APS58_RS14285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APS58_RS14295	COG0579	oxidoreductase
APS58_RS14300	COG0268	Binds directly to 16S ribosomal RNA
APS58_RS14305	COG0728	peptidoglycan biosynthetic process
APS58_RS14315	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
APS58_RS14315	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
APS58_RS14325	COG3022	response to hydroperoxide
APS58_RS14330	COG1530	ribonuclease E activity
APS58_RS14355	COG0616	signal peptide processing
APS58_RS14355	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APS58_RS14360	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APS58_RS14365	COG0424	maF-like protein
APS58_RS14370	COG1399	metal-binding, possibly nucleic acid-binding protein
APS58_RS14375	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APS58_RS14380	COG0416	fatty acid biosynthetic process
APS58_RS14385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APS58_RS14390	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APS58_RS14395	COG1028	Short-chain dehydrogenase reductase Sdr
APS58_RS14400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APS58_RS14405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APS58_RS14430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APS58_RS14435	COG0481	GTPase activity
APS58_RS14440	COG0681	Belongs to the peptidase S26 family
APS58_RS14450	COG0571	ribonuclease III activity
APS58_RS14455	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APS58_RS14460	COG1381	Involved in DNA repair and RecF pathway recombination
APS58_RS14465	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
APS58_RS14470	COG1472	Belongs to the glycosyl hydrolase 3 family
APS58_RS14475	COG3064	Membrane
APS58_RS14485	COG3706	GGDEF domain
APS58_RS14485	COG4251	negative regulation of phosphorylation
APS58_RS14485	COG5001	Diguanylate cyclase
APS58_RS14485	COG2203	Gaf domain
APS58_RS14490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APS58_RS14515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APS58_RS14530	COG0762	integral membrane protein
APS58_RS14535	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APS58_RS14540	COG0159	tryptophan synthase activity
APS58_RS14545	COG0133	tryptophan synthase activity
APS58_RS14550	COG0135	phosphoribosylanthranilate isomerase activity
APS58_RS14555	COG0101	tRNA pseudouridine synthase activity
APS58_RS14565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APS58_RS14575	COG0473	3-isopropylmalate dehydrogenase activity
APS58_RS14580	COG0066	3-isopropylmalate dehydratase activity
APS58_RS14590	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APS58_RS14600	COG0484	heat shock protein binding
APS58_RS14605	COG0443	Heat shock 70 kDa protein
APS58_RS14610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APS58_RS14615	COG0360	Binds together with S18 to 16S ribosomal RNA
APS58_RS14625	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APS58_RS14630	COG0359	binds to the 23S rRNA
APS58_RS14645	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
APS58_RS14650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APS58_RS14660	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APS58_RS14705	COG0436	Aminotransferase
APS58_RS14720	COG1763	Mo-molybdopterin cofactor biosynthetic process
APS58_RS14725	COG0303	'Molybdopterin
APS58_RS14730	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
APS58_RS14735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APS58_RS14760	COG0314	molybdopterin synthase activity
APS58_RS14765	COG0542	response to heat
APS58_RS14785	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
APS58_RS14795	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APS58_RS14800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APS58_RS14810	COG0436	Aminotransferase
APS58_RS14815	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APS58_RS14820	COG1185	polyribonucleotide nucleotidyltransferase activity
APS58_RS14825	COG0604	alcohol dehydrogenase
APS58_RS14825	COG3321	synthase
APS58_RS14825	COG1028	Short-chain dehydrogenase reductase Sdr
APS58_RS14830	COG0149	triose-phosphate isomerase activity
APS58_RS14845	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APS58_RS14850	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APS58_RS14855	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APS58_RS14860	COG0649	NAD binding
APS58_RS14865	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
APS58_RS14870	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
APS58_RS14875	COG1034	ATP synthesis coupled electron transport
APS58_RS14880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
APS58_RS14885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APS58_RS14895	COG0713	ATP synthesis coupled electron transport
APS58_RS14910	COG1007	ATP synthesis coupled electron transport
APS58_RS14925	COG1132	(ABC) transporter
APS58_RS14970	COG0463	Glycosyl transferase, family 2
APS58_RS14970	COG0457	Tetratricopeptide repeat
APS58_RS14990	COG0071	Belongs to the small heat shock protein (HSP20) family
APS58_RS14995	COG1136	(ABC) transporter
APS58_RS15000	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APS58_RS15005	COG0702	epimerase
APS58_RS15010	COG1733	regulation of RNA biosynthetic process
APS58_RS15015	COG2267	carboxylic ester hydrolase activity
APS58_RS15020	COG0584	glycerophosphoryl diester phosphodiesterase
APS58_RS15030	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APS58_RS15035	COG0586	Pfam SNARE associated Golgi protein
APS58_RS15040	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APS58_RS15055	COG0860	N-Acetylmuramoyl-L-alanine amidase
APS58_RS15060	COG0802	atpase or kinase
APS58_RS15065	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APS58_RS15095	COG4974	Belongs to the 'phage' integrase family
APS58_RS15100	COG3181	Tripartite tricarboxylate transporter family receptor
APS58_RS15105	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
APS58_RS15110	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
APS58_RS15115	COG2833	Protein of unknown function (DUF455)
APS58_RS15125	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
APS58_RS15135	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
APS58_RS15140	COG0148	phosphopyruvate hydratase activity
APS58_RS15160	COG2877	3-deoxy-8-phosphooctulonate synthase activity
APS58_RS15165	COG0504	CTP synthase activity
APS58_RS15170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APS58_RS15175	COG0756	dUTP diphosphatase activity
APS58_RS15185	COG1047	Peptidyl-prolyl cis-trans
APS58_RS15190	COG2850	peptidyl-arginine hydroxylation
APS58_RS15205	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
APS58_RS15210	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
APS58_RS15215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APS58_RS15235	COG0741	lytic transglycosylase activity
APS58_RS15245	COG0840	transmembrane signaling receptor activity
APS58_RS15250	COG0840	transmembrane signaling receptor activity
APS58_RS15255	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
APS58_RS15295	COG2308	Evidence 4 Homologs of previously reported genes of
APS58_RS15315	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
APS58_RS15325	COG4628	conserved protein (DUF2132)
APS58_RS15335	COG0657	acetylesterase activity
APS58_RS15340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APS58_RS15365	COG4774	siderophore transport
APS58_RS15410	COG3634	alkyl hydroperoxide reductase activity
APS58_RS15435	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
APS58_RS15450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APS58_RS15475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APS58_RS15490	COG0583	DNA-binding transcription factor activity
APS58_RS15495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APS58_RS15505	COG1028	Short-chain dehydrogenase reductase Sdr
APS58_RS15510	COG4948	Mandelate Racemase Muconate Lactonizing
APS58_RS15555	COG0840	transmembrane signaling receptor activity
APS58_RS15560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APS58_RS15565	COG0358	DNA primase activity
APS58_RS15570	COG5001	Diguanylate cyclase
APS58_RS15570	COG3300	MHYT domain
APS58_RS15575	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APS58_RS15580	COG0405	Gamma-glutamyltransferase
APS58_RS15585	COG3540	Alkaline phosphatase
APS58_RS15595	COG3321	synthase
APS58_RS15595	COG0604	alcohol dehydrogenase
APS58_RS15595	COG1028	Short-chain dehydrogenase reductase Sdr
APS58_RS15600	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
APS58_RS15605	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
APS58_RS15615	COG0564	pseudouridine synthase activity
APS58_RS15620	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
APS58_RS15625	COG1187	pseudouridine synthase activity
APS58_RS15630	COG0105	UTP biosynthetic process
APS58_RS15635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APS58_RS15640	COG3063	Type IV pilus biogenesis stability protein PilW
APS58_RS15650	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
APS58_RS15655	COG0124	histidyl-tRNA synthetase
APS58_RS15670	COG1160	GTP binding
APS58_RS15675	COG1923	regulation of RNA biosynthetic process
APS58_RS15680	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APS58_RS15685	COG0330	HflC and HflK could
APS58_RS15690	COG0330	HflC and HflK could
APS58_RS15695	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
APS58_RS15700	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APS58_RS15705	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
APS58_RS15735	COG1187	pseudouridine synthase activity
APS58_RS15765	COG0174	glutamine synthetase
APS58_RS15775	COG3852	Histidine kinase
APS58_RS15790	COG0708	Exodeoxyribonuclease III
APS58_RS15805	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
APS58_RS15815	COG0277	FAD linked oxidase domain protein
APS58_RS15825	COG1295	ribonuclease BN
APS58_RS15830	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
APS58_RS15855	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APS58_RS15860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APS58_RS15865	COG0740	serine-type endopeptidase activity
APS58_RS15870	COG0544	peptidyl-prolyl cis-trans isomerase activity
APS58_RS15880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APS58_RS15890	COG1562	ergosterol biosynthetic process
APS58_RS15920	COG0631	protein serine/threonine phosphatase activity
APS58_RS15935	COG2885	chlorophyll binding
APS58_RS16000	COG1451	nucleotide metabolic process
APS58_RS16005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APS58_RS16010	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
APS58_RS16015	COG2080	2 iron, 2 sulfur cluster binding
APS58_RS16020	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
APS58_RS16035	COG0114	fumarate hydratase activity
APS58_RS16045	COG0745	RESPONSE REGULATOR receiver
APS58_RS16050	COG2205	protein histidine kinase activity
APS58_RS16055	COG2113	Glycine betaine
APS58_RS16060	COG4176	ABC-type proline glycine betaine transport system permease component
APS58_RS16065	COG4175	Glycine betaine
APS58_RS16075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APS58_RS16095	COG4654	Cytochrome c, class I
APS58_RS16105	COG0129	dihydroxy-acid dehydratase activity
APS58_RS16120	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APS58_RS16125	COG1802	Transcriptional regulator
APS58_RS16150	COG0318	PFAM AMP-dependent synthetase and ligase
APS58_RS16160	COG0589	response to stress
APS58_RS16170	COG2217	Heavy metal translocating P-type atpase
APS58_RS16180	COG3278	Belongs to the heme-copper respiratory oxidase family
APS58_RS16215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APS58_RS16220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APS58_RS16230	COG3437	response regulator, receiver
APS58_RS16250	COG4206	TonB-dependent receptor
APS58_RS16255	COG1797	cobyrinic acid a,c-diamide synthase activity
APS58_RS16270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APS58_RS16275	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
APS58_RS16280	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
APS58_RS16285	COG0778	Nitroreductase
APS58_RS16290	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
APS58_RS16320	COG1028	Short-chain dehydrogenase reductase Sdr
APS58_RS16325	COG1492	cobalamin metabolic process
APS58_RS16330	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
APS58_RS16355	COG0477	Major facilitator Superfamily
APS58_RS16375	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APS58_RS16380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APS58_RS16385	COG2900	Belongs to the SlyX family
APS58_RS16400	COG0513	Belongs to the DEAD box helicase family
APS58_RS16425	COG1959	2 iron, 2 sulfur cluster binding
APS58_RS16430	COG0583	DNA-binding transcription factor activity
APS58_RS16445	COG0560	Phosphoserine phosphatase
APS58_RS16455	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
APS58_RS16465	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APS58_RS16470	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APS58_RS16470	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
APS58_RS16475	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
APS58_RS16475	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APS58_RS16495	COG1028	Short-chain dehydrogenase reductase Sdr
APS58_RS16505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APS58_RS16540	COG0693	protein deglycase activity
APS58_RS16550	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
APS58_RS16555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APS58_RS16575	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APS58_RS16590	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APS58_RS16595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APS58_RS16615	COG1446	asparaginase
APS58_RS16620	COG4172	Belongs to the ABC transporter superfamily
APS58_RS16630	COG0601	transmembrane transport
APS58_RS16635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS58_RS16655	COG0322	excinuclease ABC activity
APS58_RS16870	COG3728	DNA packaging
APS58_RS16870	COG5484	DNA packaging
APS58_RS17080	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
APS58_RS17090	COG3181	Tripartite tricarboxylate transporter family receptor
APS58_RS17095	COG0028	Belongs to the TPP enzyme family
APS58_RS17100	COG1028	Short-chain dehydrogenase reductase Sdr
APS58_RS17120	COG2267	carboxylic ester hydrolase activity
APS58_RS17170	COG1012	belongs to the aldehyde dehydrogenase family
APS58_RS17175	COG2207	Transcriptional regulator
APS58_RS17185	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APS58_RS17215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APS58_RS17215	COG4651	solute:proton antiporter activity
APS58_RS17225	COG0513	Belongs to the DEAD box helicase family
APS58_RS17230	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APS58_RS17235	COG0488	(ABC) transporter
APS58_RS17250	COG3191	aminopeptidase activity
APS58_RS17280	COG2132	Multicopper oxidase
APS58_RS17310	COG0789	Transcriptional regulator
APS58_RS17335	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APS58_RS17335	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APS58_RS17340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APS58_RS17345	COG0052	Belongs to the universal ribosomal protein uS2 family
APS58_RS17350	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APS58_RS17355	COG0528	UMP kinase activity
APS58_RS17360	COG0233	cytoplasmic translational termination
APS58_RS17370	COG0575	Belongs to the CDS family
APS58_RS17375	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
APS58_RS17380	COG0750	zinc metalloprotease
APS58_RS17395	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APS58_RS17400	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APS58_RS17405	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APS58_RS17410	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APS58_RS17415	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APS58_RS17420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APS58_RS17425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APS58_RS17430	COG3181	Tripartite tricarboxylate transporter family receptor
APS58_RS17435	COG1960	acyl-CoA dehydrogenase activity
APS58_RS17440	COG0583	DNA-binding transcription factor activity
APS58_RS17450	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
APS58_RS17455	COG0308	aminopeptidase N
APS58_RS17465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APS58_RS17480	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
APS58_RS17485	COG0667	Aldo Keto reductase
APS58_RS17490	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APS58_RS17495	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
APS58_RS17505	COG3577	Aspartyl protease
APS58_RS17510	COG1666	GTP binding
APS58_RS17520	COG0137	argininosuccinate synthase activity
APS58_RS17525	COG3123	guanosine phosphorylase activity
APS58_RS17535	COG1393	Belongs to the ArsC family
APS58_RS17540	COG0285	dihydrofolate synthase activity
APS58_RS17550	COG1286	toxin biosynthetic process
APS58_RS17565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APS58_RS17605	COG2814	Major facilitator Superfamily
APS58_RS17610	COG2814	Major facilitator Superfamily
APS58_RS17635	COG2183	response to ionizing radiation
APS58_RS17650	COG1454	alcohol dehydrogenase
APS58_RS17660	COG0657	acetylesterase activity
APS58_RS17675	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APS58_RS17680	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APS58_RS17695	COG0084	hydrolase, TatD family'
APS58_RS17705	COG1132	(ABC) transporter
APS58_RS17710	COG0823	Involved in the tonB-independent uptake of proteins
APS58_RS17715	COG2885	chlorophyll binding
APS58_RS17725	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
APS58_RS17745	COG2423	ornithine cyclodeaminase activity
APS58_RS17815	COG2010	Cytochrome c
APS58_RS17815	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APS58_RS17825	COG0779	Required for maturation of 30S ribosomal subunits
APS58_RS17830	COG0195	Participates in both transcription termination and antitermination
APS58_RS17835	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APS58_RS17840	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APS58_RS17845	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APS58_RS17855	COG1253	flavin adenine dinucleotide binding
APS58_RS17860	COG1024	Enoyl-CoA hydratase
APS58_RS17880	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APS58_RS17890	COG2914	Belongs to the UPF0125 (RnfH) family
APS58_RS17915	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APS58_RS17915	COG0519	Catalyzes the synthesis of GMP from XMP
APS58_RS17920	COG0582	viral genome integration into host DNA
APS58_RS17960	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
APS58_RS17990	COG0583	DNA-binding transcription factor activity
APS58_RS18000	COG1028	Short-chain dehydrogenase reductase Sdr
APS58_RS18065	COG2226	methyltransferase
APS58_RS18070	COG0492	ferredoxin-NADP+ reductase activity
APS58_RS18085	COG1278	Cold shock
APS58_RS18090	COG0494	nUDIX hydrolase
APS58_RS18125	COG4774	siderophore transport
APS58_RS18130	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
APS58_RS18140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APS58_RS18150	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APS58_RS18150	COG0506	proline dehydrogenase activity
APS58_RS18150	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APS58_RS18165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APS58_RS18175	COG0670	Belongs to the BI1 family
APS58_RS18180	COG3193	protein, possibly involved in utilization of glycolate and propanediol
APS58_RS18220	COG0405	Gamma-glutamyltransferase
APS58_RS18225	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
APS58_RS18230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APS58_RS18255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APS58_RS18290	COG2212	antiporter activity
APS58_RS18300	COG0651	ATP synthesis coupled electron transport
APS58_RS18305	COG1006	Multisubunit Na H antiporter MnhC subunit
APS58_RS18310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APS58_RS18310	COG2111	Na H antiporter
APS58_RS18315	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
APS58_RS18325	COG0776	regulation of translation
APS58_RS18335	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
APS58_RS18340	COG0287	Prephenate dehydrogenase
APS58_RS18345	COG0077	Prephenate dehydratase
APS58_RS18345	COG1605	Chorismate mutase
APS58_RS18350	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APS58_RS18365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APS58_RS18480	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
APS58_RS18490	COG4166	transmembrane transport
APS58_RS18495	COG4174	ABC transporter (Permease)
APS58_RS18500	COG4239	(ABC) transporter, permease
APS58_RS18505	COG4172	Belongs to the ABC transporter superfamily
APS58_RS18510	COG3447	MASE1 domain protein
APS58_RS18510	COG5001	Diguanylate cyclase
APS58_RS18510	COG5002	protein histidine kinase activity
APS58_RS18515	COG0628	permease
APS58_RS18520	COG0567	Dehydrogenase, E1 component
APS58_RS18525	COG0508	dehydrogenase complex catalyzes the overall conversion of
APS58_RS18530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APS58_RS18535	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
APS58_RS18550	COG1199	ATP-dependent helicase activity
APS58_RS18565	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
APS58_RS18570	COG0542	response to heat
APS58_RS18575	COG2951	lytic endotransglycosylase activity
APS58_RS18580	COG2925	Exonuclease
APS58_RS18590	COG3284	Transcriptional regulator
APS58_RS18610	COG1012	belongs to the aldehyde dehydrogenase family
APS58_RS18615	COG0484	heat shock protein binding
APS58_RS18650	COG0402	S-adenosylhomocysteine deaminase activity
APS58_RS18670	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APS58_RS18685	COG0625	glutathione transferase activity
APS58_RS18710	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APS58_RS18715	COG0277	FAD linked oxidase domain protein
APS58_RS18735	COG0433	COG0433 Predicted ATPase
APS58_RS18740	COG0217	transcriptional regulatory protein
APS58_RS18745	COG0151	Belongs to the GarS family
APS58_RS18750	COG0408	coproporphyrinogen oxidase activity
APS58_RS18755	COG0799	negative regulation of ribosome biogenesis
APS58_RS18760	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APS58_RS18770	COG0424	maF-like protein
APS58_RS18775	COG1530	ribonuclease E activity
APS58_RS18815	COG3593	DNA synthesis involved in DNA repair
APS58_RS18830	COG0596	Alpha beta hydrolase
APS58_RS18845	COG1028	Short-chain dehydrogenase reductase Sdr
APS58_RS18855	COG1024	Enoyl-CoA hydratase
APS58_RS18860	COG1960	acyl-CoA dehydrogenase activity
APS58_RS18870	COG0683	leucine binding
APS58_RS18905	COG0436	Aminotransferase
APS58_RS18910	COG0583	DNA-binding transcription factor activity
APS58_RS18930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APS58_RS18950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APS58_RS18970	COG0589	response to stress
APS58_RS18990	COG1028	Short-chain dehydrogenase reductase Sdr
APS58_RS18995	COG0564	pseudouridine synthase activity
APS58_RS19005	COG0545	Peptidyl-prolyl cis-trans isomerase
APS58_RS19010	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APS58_RS19010	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APS58_RS19015	COG0509	glycine decarboxylation via glycine cleavage system
APS58_RS19020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
APS58_RS19035	COG4120	Belongs to the binding-protein-dependent transport system permease family
APS58_RS19055	COG1028	Short-chain dehydrogenase reductase Sdr
APS58_RS19090	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
APS58_RS19100	COG1252	NADH dehydrogenase
APS58_RS19125	COG0835	chemotaxis
APS58_RS19130	COG3181	Tripartite tricarboxylate transporter family receptor
APS58_RS19140	COG0583	DNA-binding transcription factor activity
APS58_RS19155	COG0347	Belongs to the P(II) protein family
APS58_RS19165	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APS58_RS19185	COG1595	DNA-templated transcription, initiation
APS58_RS19190	COG0028	Belongs to the TPP enzyme family
APS58_RS19195	COG0440	acetolactate synthase activity
APS58_RS19200	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APS58_RS19205	COG1183	phosphatidylcholine synthase activity
APS58_RS19210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APS58_RS19220	COG1414	Transcriptional regulator
APS58_RS19225	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
APS58_RS19230	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
APS58_RS19245	COG2832	Protein of unknown function (DUF454)
APS58_RS19250	COG0242	peptide deformylase activity
APS58_RS19255	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
APS58_RS19260	COG0024	Methionine aminopeptidase
APS58_RS19265	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APS58_RS19265	COG0047	phosphoribosylformylglycinamidine synthase activity
APS58_RS19280	COG3300	MHYT domain
APS58_RS19280	COG5001	Diguanylate cyclase
APS58_RS19285	COG2354	Protein conserved in bacteria
APS58_RS19290	COG3047	cAMP biosynthetic process
APS58_RS19305	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
APS58_RS19310	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APS58_RS19320	COG0823	Involved in the tonB-independent uptake of proteins
APS58_RS19320	COG4946	Tricorn protease homolog
APS58_RS19320	COG1506	peptidase
APS58_RS19330	COG0826	peptidase U32
APS58_RS19355	COG1619	proteins homologs of microcin C7 resistance protein MccF
APS58_RS19370	COG1960	acyl-CoA dehydrogenase activity
APS58_RS19385	COG1024	Enoyl-CoA hydratase
APS58_RS19390	COG1250	3-hydroxyacyl-CoA dehydrogenase
APS58_RS19405	COG2022	thiamine diphosphate biosynthetic process
APS58_RS19420	COG0351	phosphomethylpyrimidine kinase
APS58_RS19465	COG0492	ferredoxin-NADP+ reductase activity
APS58_RS19470	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
APS58_RS19475	COG2895	sulfate adenylyltransferase (ATP) activity
APS58_RS19475	COG0529	Catalyzes the synthesis of activated sulfate
APS58_RS19480	COG0175	sulfate reduction
APS58_RS19495	COG0730	response to heat
APS58_RS19515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APS58_RS19515	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
APS58_RS19520	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
APS58_RS19530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APS58_RS19540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APS58_RS19550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APS58_RS19555	COG1116	anion transmembrane transporter activity
APS58_RS19565	COG0583	DNA-binding transcription factor activity
APS58_RS19590	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APS58_RS19600	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APS58_RS19605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APS58_RS19615	COG0583	DNA-binding transcription factor activity
APS58_RS19620	COG1741	Belongs to the pirin family
APS58_RS19630	COG1741	Belongs to the pirin family
APS58_RS19635	COG1054	Belongs to the UPF0176 family
APS58_RS19675	COG4181	ATPase activity
APS58_RS19680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APS58_RS19685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APS58_RS19690	COG0667	Aldo Keto reductase
APS58_RS19705	COG0642	Histidine kinase
APS58_RS19715	COG3181	Tripartite tricarboxylate transporter family receptor
APS58_RS19765	COG5002	protein histidine kinase activity
APS58_RS19770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APS58_RS19775	COG1011	Hydrolase
APS58_RS19790	COG0517	IMP dehydrogenase activity
APS58_RS19790	COG1125	glycine betaine transport
APS58_RS19795	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APS58_RS19805	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APS58_RS19810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APS58_RS19815	COG0741	lytic transglycosylase activity
APS58_RS19840	COG0557	exoribonuclease II activity
APS58_RS19845	COG1028	Short-chain dehydrogenase reductase Sdr
APS58_RS19855	COG0297	glycogen (starch) synthase activity
APS58_RS19875	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APS58_RS19895	COG0784	Response regulator, receiver
APS58_RS19895	COG4191	Histidine kinase
APS58_RS19900	COG2205	protein histidine kinase activity
APS58_RS19905	COG2205	protein histidine kinase activity
APS58_RS19915	COG2172	sigma factor antagonist activity
APS58_RS19920	COG1366	Belongs to the anti-sigma-factor antagonist family
APS58_RS19925	COG1366	Belongs to the anti-sigma-factor antagonist family
APS58_RS19935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APS58_RS19945	COG2188	Transcriptional regulator
APS58_RS19950	COG2986	histidine ammonia-lyase
APS58_RS19955	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
APS58_RS19970	COG1228	amidohydrolase
APS58_RS19985	COG5006	permease, DMT superfamily
APS58_RS20000	COG0688	phosphatidylethanolamine metabolic process
APS58_RS20005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APS58_RS20025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APS58_RS20035	COG2917	probably involved in intracellular septation
APS58_RS20040	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APS58_RS20045	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
APS58_RS20050	COG0318	PFAM AMP-dependent synthetase and ligase
APS58_RS20060	COG0559	Belongs to the binding-protein-dependent transport system permease family
APS58_RS20070	COG0411	ABC transporter
APS58_RS20095	COG3706	GGDEF domain
APS58_RS20110	COG1024	Enoyl-CoA hydratase
APS58_RS20110	COG1250	3-hydroxyacyl-CoA dehydrogenase
APS58_RS20115	COG0183	Belongs to the thiolase family
APS58_RS20120	COG2050	protein possibly involved in aromatic compounds catabolism
APS58_RS20125	COG1960	acyl-CoA dehydrogenase activity
APS58_RS20145	COG2130	NADP-dependent
APS58_RS20150	COG2153	protein acetylation
APS58_RS20170	COG1840	ABC-type Fe3 transport system, periplasmic component
APS58_RS20180	COG0697	spore germination
APS58_RS20185	COG1522	sequence-specific DNA binding
APS58_RS20200	COG2224	Isocitrate lyase
APS58_RS20205	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APS58_RS20210	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APS58_RS20215	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APS58_RS20220	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APS58_RS20225	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APS58_RS20230	COG0072	phenylalanine-tRNA ligase activity
APS58_RS20230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APS58_RS20235	COG0776	regulation of translation
APS58_RS20240	COG0789	Transcriptional regulator
APS58_RS20265	COG1132	(ABC) transporter
APS58_RS20270	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
APS58_RS20280	COG1742	UPF0060 membrane protein
APS58_RS20290	COG1196	nuclear chromosome segregation
APS58_RS20300	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APS58_RS20315	COG3264	Mechanosensitive ion channel
APS58_RS20315	COG1511	domain protein
APS58_RS20330	COG1960	acyl-CoA dehydrogenase activity
APS58_RS20375	COG1473	amidohydrolase
APS58_RS20380	COG1522	sequence-specific DNA binding
APS58_RS20390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APS58_RS20410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APS58_RS20420	COG0601	transmembrane transport
APS58_RS20425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS58_RS20435	COG0473	3-isopropylmalate dehydrogenase activity
APS58_RS20445	COG2194	sulfuric ester hydrolase activity
APS58_RS20450	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
APS58_RS20460	COG4977	sequence-specific DNA binding
APS58_RS20465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APS58_RS20475	COG0372	Belongs to the citrate synthase family
APS58_RS20480	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
APS58_RS20485	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APS58_RS20490	COG1053	succinate dehydrogenase
APS58_RS20505	COG2188	Transcriptional regulator
APS58_RS20510	COG0039	L-malate dehydrogenase activity
APS58_RS20515	COG4106	trans-aconitate 2-methyltransferase activity
APS58_RS20530	COG1049	propionate catabolic process, 2-methylcitrate cycle
APS58_RS20535	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
APS58_RS20550	COG0826	peptidase U32
APS58_RS20555	COG0583	DNA-binding transcription factor activity
APS58_RS20580	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
APS58_RS20585	COG1845	cytochrome c oxidase, subunit III
APS58_RS20590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APS58_RS20595	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
APS58_RS20600	COG0477	Major facilitator Superfamily
APS58_RS20620	COG0824	Thioesterase
APS58_RS20625	COG0436	Aminotransferase
APS58_RS20630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APS58_RS20635	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
APS58_RS20660	COG2202	Pas domain
APS58_RS20660	COG2205	protein histidine kinase activity
APS58_RS20670	COG0745	RESPONSE REGULATOR receiver
APS58_RS20675	COG2201	protein-glutamate methylesterase activity
APS58_RS20695	COG1289	transmembrane transporter activity
APS58_RS20700	COG4948	Mandelate Racemase Muconate Lactonizing
APS58_RS20705	COG0800	Aldolase
APS58_RS20710	COG3734	2-keto-3-deoxy-galactonokinase
APS58_RS20730	COG1172	Belongs to the binding-protein-dependent transport system permease family
APS58_RS20735	COG1172	Belongs to the binding-protein-dependent transport system permease family
APS58_RS20745	COG4214	carbohydrate transport
APS58_RS20755	COG4213	ABC transporter substrate-binding protein
APS58_RS20760	COG1879	ABC-type sugar transport system periplasmic component
APS58_RS20780	COG3386	PFAM SMP-30 Gluconolaconase
APS58_RS20790	COG2918	glutathione biosynthetic process
APS58_RS20800	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APS58_RS20815	COG5002	protein histidine kinase activity
APS58_RS20830	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
APS58_RS20850	COG2814	Major facilitator Superfamily
APS58_RS20865	COG1285	pathogenesis
APS58_RS20870	COG0564	pseudouridine synthase activity
APS58_RS20900	COG0840	transmembrane signaling receptor activity
APS58_RS20930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APS58_RS20970	COG1309	transcriptional regulator
APS58_RS20985	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APS58_RS20995	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APS58_RS21010	COG3384	dioxygenase
APS58_RS21030	COG1522	sequence-specific DNA binding
APS58_RS21085	COG0215	cysteine-tRNA ligase activity
APS58_RS21100	COG0037	tRNA processing
APS58_RS21105	COG0527	aspartate kinase activity
APS58_RS21165	COG3209	COG3209 Rhs family protein
APS58_RS21210	COG0791	NLP P60 protein
APS58_RS21215	COG2133	pyrroloquinoline quinone binding
APS58_RS21265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APS58_RS21265	COG0045	succinate-CoA ligase (ADP-forming) activity
APS58_RS21265	COG1042	CoA-binding domain protein
APS58_RS21285	COG1309	transcriptional regulator
APS58_RS21290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APS58_RS21300	COG1136	(ABC) transporter
APS58_RS21325	COG4771	TonB-dependent receptor
APS58_RS21330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APS58_RS21345	COG0259	pyridoxamine-phosphate oxidase activity
APS58_RS21370	COG1609	Transcriptional regulator
APS58_RS21375	COG3265	gluconokinase activity
APS58_RS21380	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
APS58_RS21385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APS58_RS21390	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APS58_RS21400	COG0800	Aldolase
APS58_RS21410	COG0346	lactoylglutathione lyase activity
APS58_RS21415	COG1028	Short-chain dehydrogenase reductase Sdr
APS58_RS21455	COG0583	DNA-binding transcription factor activity
APS58_RS21460	COG0431	NADPH-dependent FMN reductase
APS58_RS21475	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APS58_RS21505	COG0564	pseudouridine synthase activity
APS58_RS21510	COG2982	Protein involved in outer membrane biogenesis
APS58_RS21515	COG0587	DNA-directed DNA polymerase activity
APS58_RS21530	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APS58_RS21555	COG1012	belongs to the aldehyde dehydrogenase family
APS58_RS21580	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APS58_RS21585	COG0746	molybdenum cofactor guanylyltransferase activity
APS58_RS21595	COG0303	'Molybdopterin
APS58_RS21610	COG0328	RNA-DNA hybrid ribonuclease activity
APS58_RS21615	COG2226	methyltransferase
APS58_RS21620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APS58_RS21625	COG1388	LysM domain
APS58_RS21625	COG0741	lytic transglycosylase activity
APS58_RS21645	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APS58_RS21650	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APS58_RS21655	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APS58_RS21670	COG2081	HI0933 family
APS58_RS21675	COG1074	ATP-dependent DNA helicase activity
APS58_RS21690	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APS58_RS21695	COG0419	ATPase involved in DNA repair
APS58_RS21700	COG0420	3'-5' exonuclease activity
APS58_RS21705	COG0254	rRNA binding
APS58_RS21715	COG0534	Mate efflux family protein
APS58_RS21730	COG0704	Plays a role in the regulation of phosphate uptake
APS58_RS21735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APS58_RS21740	COG0581	inorganic phosphate transmembrane transporter activity
APS58_RS21745	COG0573	inorganic phosphate transmembrane transporter activity
APS58_RS21750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APS58_RS21755	COG0248	Ppx GppA phosphatase
APS58_RS21785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APS58_RS21795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APS58_RS21800	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
APS58_RS21805	COG1534	Rna-binding protein
APS58_RS21820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APS58_RS21825	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APS58_RS21830	COG0505	Belongs to the CarA family
APS58_RS21840	COG1113	amino acid transport
APS58_RS21865	COG1960	acyl-CoA dehydrogenase activity
APS58_RS21880	COG2032	superoxide dismutase activity
APS58_RS21885	COG4772	TonB-dependent receptor
APS58_RS21900	COG2721	sulfolactate sulfo-lyase activity
APS58_RS21915	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APS58_RS21925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APS58_RS21935	COG3181	Tripartite tricarboxylate transporter family receptor
APS58_RS21940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APS58_RS21980	COG0789	Transcriptional regulator
APS58_RS21985	COG2814	Major facilitator Superfamily
APS58_RS22000	COG1942	4-Oxalocrotonate Tautomerase
APS58_RS22005	COG0625	glutathione transferase activity
APS58_RS22035	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APS58_RS22040	COG1570	exodeoxyribonuclease VII activity
APS58_RS22045	COG0811	peptide transport
APS58_RS22050	COG0848	biopolymer transport protein
APS58_RS22055	COG1663	tetraacyldisaccharide 4'-kinase activity
APS58_RS22060	COG2835	tetraacyldisaccharide 4'-kinase activity
APS58_RS22065	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
APS58_RS22070	COG0563	adenylate kinase activity
APS58_RS22095	COG3736	Type IV secretory pathway, component VirB8
APS58_RS22100	COG3504	Conjugal transfer protein
APS58_RS22115	COG3505	Type IV secretory pathway VirD4
APS58_RS22120	COG2885	chlorophyll binding
APS58_RS22290	COG1475	DNA binding
APS58_RS22320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair