locus-tag	class	description
DTPSY_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DTPSY_RS00025	COG0456	acetyltransferase
DTPSY_RS00035	COG1764	response to oxidative stress
DTPSY_RS00045	COG1254	Belongs to the acylphosphatase family
DTPSY_RS00070	COG1199	ATP-dependent helicase activity
DTPSY_RS00095	COG0791	NLP P60 protein
DTPSY_RS00100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DTPSY_RS00130	COG2974	May be involved in recombination
DTPSY_RS00135	COG1301	dicarboxylic acid transport
DTPSY_RS00140	COG2205	protein histidine kinase activity
DTPSY_RS00140	COG0784	Response regulator, receiver
DTPSY_RS00140	COG2198	Histidine kinase
DTPSY_RS00150	COG0700	Nucleoside recognition
DTPSY_RS00160	COG0183	Belongs to the thiolase family
DTPSY_RS00175	COG0789	Transcriptional regulator
DTPSY_RS00190	COG0840	transmembrane signaling receptor activity
DTPSY_RS00210	COG0625	glutathione transferase activity
DTPSY_RS00225	COG0445	tRNA wobble uridine modification
DTPSY_RS00230	COG0357	Ribosomal RNA small subunit methyltransferase G
DTPSY_RS00240	COG1192	Involved in chromosome partitioning
DTPSY_RS00250	COG1475	DNA binding
DTPSY_RS00280	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
DTPSY_RS00285	COG0655	NAD(P)H dehydrogenase (quinone) activity
DTPSY_RS00290	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DTPSY_RS00305	COG0277	FAD linked oxidase domain protein
DTPSY_RS00315	COG2096	Adenosyltransferase
DTPSY_RS00320	COG2050	protein possibly involved in aromatic compounds catabolism
DTPSY_RS00340	COG2233	PERMEase
DTPSY_RS00355	COG2199	diguanylate cyclase activity
DTPSY_RS00355	COG2203	Gaf domain
DTPSY_RS00370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DTPSY_RS00375	COG0583	DNA-binding transcription factor activity
DTPSY_RS00390	COG1960	acyl-CoA dehydrogenase activity
DTPSY_RS00410	COG1183	phosphatidylcholine synthase activity
DTPSY_RS00415	COG0850	regulation of cytokinetic process
DTPSY_RS00425	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DTPSY_RS00430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DTPSY_RS00445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DTPSY_RS00450	COG0583	DNA-binding transcription factor activity
DTPSY_RS00480	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DTPSY_RS00485	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DTPSY_RS00490	COG1960	acyl-CoA dehydrogenase activity
DTPSY_RS00505	COG0514	ATP-dependent DNA helicase (RecQ)
DTPSY_RS00535	COG3256	nitric oxide reductase
DTPSY_RS00540	COG3604	Transcriptional regulator
DTPSY_RS00550	COG1760	l-serine dehydratase
DTPSY_RS00560	COG3181	Tripartite tricarboxylate transporter family receptor
DTPSY_RS00565	COG0318	PFAM AMP-dependent synthetase and ligase
DTPSY_RS00600	COG0183	Belongs to the thiolase family
DTPSY_RS00610	COG1024	Enoyl-CoA hydratase
DTPSY_RS00620	COG1028	Short-chain dehydrogenase reductase Sdr
DTPSY_RS00625	COG1024	Enoyl-CoA hydratase
DTPSY_RS00635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DTPSY_RS00670	COG1960	acyl-CoA dehydrogenase activity
DTPSY_RS00675	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
DTPSY_RS00680	COG1028	Short-chain dehydrogenase reductase Sdr
DTPSY_RS00685	COG2030	dehydratase
DTPSY_RS00690	COG1024	Enoyl-CoA hydratase
DTPSY_RS00695	COG0427	acetyl-CoA hydrolase
DTPSY_RS00700	COG0183	Belongs to the thiolase family
DTPSY_RS00710	COG0318	PFAM AMP-dependent synthetase and ligase
DTPSY_RS00730	COG1960	acyl-CoA dehydrogenase activity
DTPSY_RS00740	COG0583	DNA-binding transcription factor activity
DTPSY_RS00745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DTPSY_RS00755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DTPSY_RS00760	COG2326	polyphosphate kinase activity
DTPSY_RS00765	COG0583	DNA-binding transcription factor activity
DTPSY_RS00775	COG0583	DNA-binding transcription factor activity
DTPSY_RS00785	COG4829	muconolactone delta-isomerase
DTPSY_RS00805	COG0723	plastoquinol--plastocyanin reductase activity
DTPSY_RS00810	COG2204	response regulator
DTPSY_RS00820	COG2989	Protein conserved in bacteria
DTPSY_RS00825	COG3108	Peptidase M15
DTPSY_RS00830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DTPSY_RS00850	COG0683	leucine binding
DTPSY_RS00860	COG0411	ABC transporter
DTPSY_RS00870	COG0583	DNA-binding transcription factor activity
DTPSY_RS00875	COG1028	Short-chain dehydrogenase reductase Sdr
DTPSY_RS00880	COG0840	transmembrane signaling receptor activity
DTPSY_RS00895	COG0347	Belongs to the P(II) protein family
DTPSY_RS00900	COG0004	ammonium transporteR
DTPSY_RS00910	COG0277	FAD linked oxidase domain protein
DTPSY_RS00920	COG0247	lactate metabolic process
DTPSY_RS00945	COG0386	Belongs to the glutathione peroxidase family
DTPSY_RS00955	COG0477	Major facilitator Superfamily
DTPSY_RS00960	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DTPSY_RS00970	COG1858	cytochrome C peroxidase
DTPSY_RS00975	COG0625	glutathione transferase activity
DTPSY_RS01010	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DTPSY_RS01020	COG3307	-O-antigen
DTPSY_RS01035	COG0477	Major facilitator Superfamily
DTPSY_RS01040	COG2258	MOSC domain
DTPSY_RS01050	COG2205	protein histidine kinase activity
DTPSY_RS01055	COG0745	RESPONSE REGULATOR receiver
DTPSY_RS01080	COG0501	Belongs to the peptidase M48B family
DTPSY_RS01090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DTPSY_RS01105	COG1960	acyl-CoA dehydrogenase activity
DTPSY_RS01120	COG0708	Exodeoxyribonuclease III
DTPSY_RS01125	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DTPSY_RS01135	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DTPSY_RS01140	COG0154	amidase activity
DTPSY_RS01145	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DTPSY_RS01150	COG1077	Cell shape determining protein MreB Mrl
DTPSY_RS01160	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DTPSY_RS01165	COG0768	penicillin binding
DTPSY_RS01175	COG1126	abc transporter atp-binding protein
DTPSY_RS01180	COG0765	amino acid transport
DTPSY_RS01185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DTPSY_RS01205	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DTPSY_RS01210	COG1127	ABC transporter
DTPSY_RS01225	COG3237	CsbD-like
DTPSY_RS01240	COG4251	negative regulation of phosphorylation
DTPSY_RS01240	COG3706	GGDEF domain
DTPSY_RS01240	COG2203	Gaf domain
DTPSY_RS01240	COG5001	Diguanylate cyclase
DTPSY_RS01245	COG2095	MarC family integral membrane protein
DTPSY_RS01250	COG1028	Short-chain dehydrogenase reductase Sdr
DTPSY_RS01255	COG0412	Dienelactone hydrolase
DTPSY_RS01265	COG1566	PFAM secretion protein HlyD family protein
DTPSY_RS01270	COG1538	Outer membrane efflux protein
DTPSY_RS01275	COG1846	Transcriptional regulator
DTPSY_RS01280	COG0598	Magnesium transport protein CorA
DTPSY_RS01295	COG1981	membrane
DTPSY_RS01310	COG2945	thiolester hydrolase activity
DTPSY_RS01315	COG1686	Belongs to the peptidase S11 family
DTPSY_RS01320	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DTPSY_RS01325	COG0049	tRNA binding
DTPSY_RS01330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DTPSY_RS01335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DTPSY_RS01340	COG0051	transcription antitermination factor activity, RNA binding
DTPSY_RS01345	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DTPSY_RS01350	COG0088	Forms part of the polypeptide exit tunnel
DTPSY_RS01355	COG0089	rRNA binding
DTPSY_RS01360	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DTPSY_RS01365	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DTPSY_RS01370	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DTPSY_RS01375	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DTPSY_RS01380	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DTPSY_RS01385	COG0255	Belongs to the universal ribosomal protein uL29 family
DTPSY_RS01390	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DTPSY_RS01395	COG0678	peroxiredoxin activity
DTPSY_RS01400	COG0456	acetyltransferase
DTPSY_RS01415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DTPSY_RS01435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DTPSY_RS01440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DTPSY_RS01445	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DTPSY_RS01450	COG0321	lipoyl(octanoyl) transferase activity
DTPSY_RS01455	COG2921	Belongs to the UPF0250 family
DTPSY_RS01465	COG0356	it plays a direct role in the translocation of protons across the membrane
DTPSY_RS01475	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DTPSY_RS01480	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DTPSY_RS01485	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DTPSY_RS01490	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DTPSY_RS01495	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DTPSY_RS01500	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DTPSY_RS01505	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DTPSY_RS01505	COG1793	dna ligase
DTPSY_RS01510	COG1793	dna ligase
DTPSY_RS01515	COG1201	RNA secondary structure unwinding
DTPSY_RS01555	COG3245	cytochrome
DTPSY_RS01565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DTPSY_RS01570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DTPSY_RS01595	COG1063	alcohol dehydrogenase
DTPSY_RS01605	COG0121	glutamine amidotransferase
DTPSY_RS01610	COG1942	4-Oxalocrotonate Tautomerase
DTPSY_RS01620	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DTPSY_RS01645	COG0018	arginyl-trna synthetase
DTPSY_RS01665	COG1137	ATPase activity
DTPSY_RS01670	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DTPSY_RS01690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DTPSY_RS01695	COG3012	SEC-C Motif Domain Protein
DTPSY_RS01695	COG3318	Belongs to the UPF0149 family
DTPSY_RS01700	COG1058	Belongs to the CinA family
DTPSY_RS01700	COG1546	Belongs to the CinA family
DTPSY_RS01705	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DTPSY_RS01715	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DTPSY_RS01730	COG2967	ApaG domain
DTPSY_RS01735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DTPSY_RS01745	COG0546	phosphoglycolate phosphatase activity
DTPSY_RS01755	COG0840	transmembrane signaling receptor activity
DTPSY_RS01780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DTPSY_RS01785	COG0134	indole-3-glycerol-phosphate synthase activity
DTPSY_RS01790	COG3706	GGDEF domain
DTPSY_RS01795	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DTPSY_RS01805	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DTPSY_RS01815	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DTPSY_RS01825	COG0783	Belongs to the Dps family
DTPSY_RS01835	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DTPSY_RS01845	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DTPSY_RS01855	COG3842	ATPase activity
DTPSY_RS01860	COG3842	ATPase activity
DTPSY_RS01870	COG0395	ABC-type sugar transport system, permease component
DTPSY_RS01885	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DTPSY_RS01890	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DTPSY_RS01895	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DTPSY_RS01900	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DTPSY_RS01905	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DTPSY_RS01910	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DTPSY_RS01915	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DTPSY_RS01920	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DTPSY_RS01925	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DTPSY_RS01930	COG1841	ribosomal large subunit assembly
DTPSY_RS01935	COG0200	Binds to the 23S rRNA
DTPSY_RS01940	COG0201	protein transport
DTPSY_RS01945	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DTPSY_RS01950	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DTPSY_RS01955	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DTPSY_RS01960	COG0202	RNA polymerase activity
DTPSY_RS01965	COG0203	ribosomal protein L17
DTPSY_RS01985	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DTPSY_RS01990	COG0463	Glycosyl transferase, family 2
DTPSY_RS02005	COG0792	nuclease activity
DTPSY_RS02010	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DTPSY_RS02015	COG2823	Periplasmic or secreted lipoprotein
DTPSY_RS02020	COG2084	Dehydrogenase
DTPSY_RS02030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DTPSY_RS02040	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DTPSY_RS02050	COG2733	membrane
DTPSY_RS02060	COG0277	FAD linked oxidase domain protein
DTPSY_RS02065	COG0583	DNA-binding transcription factor activity
DTPSY_RS02090	COG3850	Histidine kinase
DTPSY_RS02095	COG2197	response regulator
DTPSY_RS02105	COG2223	nitrite transmembrane transporter activity
DTPSY_RS02110	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DTPSY_RS02115	COG1140	nitrate reductase beta subunit
DTPSY_RS02120	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DTPSY_RS02125	COG2181	nitrate reductase activity
DTPSY_RS02155	COG3945	hemerythrin HHE cation binding domain
DTPSY_RS02185	COG0243	molybdopterin cofactor binding
DTPSY_RS02195	COG1473	amidohydrolase
DTPSY_RS02215	COG2818	Glycosylase
DTPSY_RS02225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DTPSY_RS02275	COG1022	Amp-dependent synthetase and ligase
DTPSY_RS02280	COG3267	Type II secretory pathway component ExeA
DTPSY_RS02280	COG3409	Peptidoglycan-binding domain 1 protein
DTPSY_RS02290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DTPSY_RS02295	COG1187	pseudouridine synthase activity
DTPSY_RS02300	COG0326	Molecular chaperone. Has ATPase activity
DTPSY_RS02305	COG3181	Tripartite tricarboxylate transporter family receptor
DTPSY_RS02335	COG1764	response to oxidative stress
DTPSY_RS02340	COG1846	Transcriptional regulator
DTPSY_RS02350	COG1250	3-hydroxyacyl-CoA dehydrogenase
DTPSY_RS02380	COG0842	Transport permease protein
DTPSY_RS02395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DTPSY_RS02405	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DTPSY_RS02410	COG1490	D-aminoacyl-tRNA deacylase activity
DTPSY_RS02415	COG0513	Belongs to the DEAD box helicase family
DTPSY_RS02420	COG0730	response to heat
DTPSY_RS02425	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DTPSY_RS02430	COG1702	phosphate starvation-inducible protein PhoH
DTPSY_RS02435	COG0632	four-way junction helicase activity
DTPSY_RS02445	COG0443	Heat shock 70 kDa protein
DTPSY_RS02450	COG2249	NAD(P)H dehydrogenase (quinone) activity
DTPSY_RS02455	COG0443	Heat shock 70 kDa protein
DTPSY_RS02465	COG2255	four-way junction helicase activity
DTPSY_RS02495	COG0037	tRNA processing
DTPSY_RS02525	COG2175	clavaminate synthase activity
DTPSY_RS02535	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DTPSY_RS02540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DTPSY_RS02555	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DTPSY_RS02560	COG3387	PFAM Glycoside hydrolase 15-related
DTPSY_RS02565	COG1877	trehalose-phosphatase activity
DTPSY_RS02575	COG0617	tRNA 3'-terminal CCA addition
DTPSY_RS02585	COG0625	glutathione transferase activity
DTPSY_RS02590	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DTPSY_RS02610	COG3128	pkhd-type hydroxylase
DTPSY_RS02620	COG4774	siderophore transport
DTPSY_RS02625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DTPSY_RS02630	COG0318	PFAM AMP-dependent synthetase and ligase
DTPSY_RS02640	COG3186	Phenylalanine-4-hydroxylase
DTPSY_RS02655	COG1522	sequence-specific DNA binding
DTPSY_RS02665	COG4535	Mg2 and Co2 transporter CorC
DTPSY_RS02670	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DTPSY_RS02675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DTPSY_RS02685	COG0752	glycyl-tRNA synthetase alpha subunit
DTPSY_RS02690	COG0751	glycine-tRNA ligase activity
DTPSY_RS02695	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DTPSY_RS02700	COG0204	Acyl-transferase
DTPSY_RS02715	COG1652	LysM domain
DTPSY_RS02720	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DTPSY_RS02740	COG1091	dTDP-4-dehydrorhamnose reductase activity
DTPSY_RS02755	COG0438	transferase activity, transferring glycosyl groups
DTPSY_RS02770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DTPSY_RS02775	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DTPSY_RS02780	COG1216	Glycosyl transferase, family 2
DTPSY_RS02780	COG0438	transferase activity, transferring glycosyl groups
DTPSY_RS02785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DTPSY_RS02800	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DTPSY_RS02800	COG0662	Cupin 2, conserved barrel domain protein
DTPSY_RS02810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DTPSY_RS02815	COG1309	transcriptional regulator
DTPSY_RS02825	COG1960	acyl-CoA dehydrogenase activity
DTPSY_RS02835	COG1024	Enoyl-CoA hydratase
DTPSY_RS02835	COG1250	3-hydroxyacyl-CoA dehydrogenase
DTPSY_RS02840	COG0183	Belongs to the thiolase family
DTPSY_RS02855	COG1024	Enoyl-CoA hydratase
DTPSY_RS02870	COG1607	acyl-coa hydrolase
DTPSY_RS02875	COG5265	(ABC) transporter
DTPSY_RS02885	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DTPSY_RS02890	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DTPSY_RS02890	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DTPSY_RS02895	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DTPSY_RS02900	COG0583	DNA-binding transcription factor activity
DTPSY_RS02910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DTPSY_RS02915	COG0765	amino acid transport
DTPSY_RS02920	COG0765	amino acid transport
DTPSY_RS02925	COG1126	abc transporter atp-binding protein
DTPSY_RS02930	COG2423	ornithine cyclodeaminase activity
DTPSY_RS02935	COG1522	sequence-specific DNA binding
DTPSY_RS02940	COG2010	Cytochrome c
DTPSY_RS02950	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DTPSY_RS02955	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DTPSY_RS02965	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DTPSY_RS02975	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DTPSY_RS02980	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DTPSY_RS02990	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DTPSY_RS02995	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DTPSY_RS03010	COG0316	Belongs to the HesB IscA family
DTPSY_RS03015	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DTPSY_RS03025	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DTPSY_RS03035	COG0583	DNA-binding transcription factor activity
DTPSY_RS03045	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DTPSY_RS03050	COG4191	Histidine kinase
DTPSY_RS03065	COG1522	sequence-specific DNA binding
DTPSY_RS03090	COG1064	alcohol dehydrogenase
DTPSY_RS03095	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DTPSY_RS03105	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DTPSY_RS03115	COG2205	protein histidine kinase activity
DTPSY_RS03130	COG0318	PFAM AMP-dependent synthetase and ligase
DTPSY_RS03135	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DTPSY_RS03140	COG3045	CreA protein
DTPSY_RS03145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DTPSY_RS03145	COG0189	ligase activity
DTPSY_RS03150	COG0189	ligase activity
DTPSY_RS03150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DTPSY_RS03155	COG1132	(ABC) transporter
DTPSY_RS03185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DTPSY_RS03255	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DTPSY_RS03260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DTPSY_RS03265	COG1765	OsmC-like protein
DTPSY_RS03270	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
DTPSY_RS03285	COG4166	transmembrane transport
DTPSY_RS03295	COG1473	amidohydrolase
DTPSY_RS03305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DTPSY_RS03310	COG0444	Belongs to the ABC transporter superfamily
DTPSY_RS03315	COG4608	Belongs to the ABC transporter superfamily
DTPSY_RS03320	COG0737	Belongs to the 5'-nucleotidase family
DTPSY_RS03325	COG1881	PFAM PEBP family protein
DTPSY_RS03335	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DTPSY_RS03340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DTPSY_RS03345	COG0166	Belongs to the GPI family
DTPSY_RS03355	COG0459	protein refolding
DTPSY_RS03360	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DTPSY_RS03365	COG1056	cytidyltransferase-related domain
DTPSY_RS03365	COG1051	belongs to the nudix hydrolase family
DTPSY_RS03380	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DTPSY_RS03390	COG1560	Kdo2-lipid A biosynthetic process
DTPSY_RS03405	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DTPSY_RS03415	COG1333	cytochrome c biogenesis protein
DTPSY_RS03420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DTPSY_RS03425	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DTPSY_RS03430	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DTPSY_RS03445	COG1965	Belongs to the frataxin family
DTPSY_RS03480	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DTPSY_RS03500	COG0070	glutamate synthase
DTPSY_RS03500	COG0069	glutamate synthase activity
DTPSY_RS03500	COG0067	glutamate synthase
DTPSY_RS03515	COG0765	amino acid transport
DTPSY_RS03525	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DTPSY_RS03530	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DTPSY_RS03535	COG1127	ABC transporter
DTPSY_RS03540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DTPSY_RS03545	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DTPSY_RS03565	COG1131	(ABC) transporter
DTPSY_RS03570	COG0842	Transport permease protein
DTPSY_RS03575	COG5007	Belongs to the BolA IbaG family
DTPSY_RS03580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DTPSY_RS03585	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DTPSY_RS03590	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DTPSY_RS03600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DTPSY_RS03605	COG0131	Imidazoleglycerol-phosphate dehydratase
DTPSY_RS03615	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DTPSY_RS03640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DTPSY_RS03645	COG0107	imidazoleglycerol-phosphate synthase activity
DTPSY_RS03650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DTPSY_RS03655	COG0140	phosphoribosyl-ATP diphosphatase activity
DTPSY_RS03670	COG0537	adenosine 5'-monophosphoramidase activity
DTPSY_RS03675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DTPSY_RS03680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DTPSY_RS03685	COG0805	protein transport
DTPSY_RS03690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DTPSY_RS03700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DTPSY_RS03705	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DTPSY_RS03710	COG1970	mechanosensitive ion channel activity
DTPSY_RS03715	COG0723	plastoquinol--plastocyanin reductase activity
DTPSY_RS03720	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DTPSY_RS03725	COG2857	Cytochrome c1
DTPSY_RS03730	COG0625	glutathione transferase activity
DTPSY_RS03735	COG2969	positive regulation of protein catabolic process
DTPSY_RS03745	COG0739	heme binding
DTPSY_RS03750	COG0653	protein targeting
DTPSY_RS03755	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DTPSY_RS03765	COG0494	nUDIX hydrolase
DTPSY_RS03770	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DTPSY_RS03775	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
DTPSY_RS03780	COG0237	dephospho-CoA kinase activity
DTPSY_RS03805	COG0142	geranyltranstransferase activity
DTPSY_RS03810	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DTPSY_RS03815	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DTPSY_RS03820	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DTPSY_RS03825	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DTPSY_RS03830	COG0494	nUDIX hydrolase
DTPSY_RS03835	COG0442	prolyl-tRNA aminoacylation
DTPSY_RS03840	COG0741	lytic transglycosylase activity
DTPSY_RS03845	COG1253	flavin adenine dinucleotide binding
DTPSY_RS03850	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DTPSY_RS03860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DTPSY_RS03865	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DTPSY_RS03875	COG0583	DNA-binding transcription factor activity
DTPSY_RS03890	COG3264	Mechanosensitive ion channel
DTPSY_RS03890	COG1511	domain protein
DTPSY_RS03895	COG0584	glycerophosphoryl diester phosphodiesterase
DTPSY_RS03900	COG3842	ATPase activity
DTPSY_RS03905	COG0395	ABC-type sugar transport system, permease component
DTPSY_RS03910	COG1175	transmembrane transport
DTPSY_RS03915	COG1653	transport
DTPSY_RS03920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DTPSY_RS03940	COG2226	methyltransferase
DTPSY_RS03955	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DTPSY_RS03975	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DTPSY_RS03995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DTPSY_RS04000	COG0302	gtp cyclohydrolase
DTPSY_RS04040	COG0154	amidase activity
DTPSY_RS04050	COG4608	Belongs to the ABC transporter superfamily
DTPSY_RS04055	COG0444	Belongs to the ABC transporter superfamily
DTPSY_RS04060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DTPSY_RS04070	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DTPSY_RS04075	COG0193	aminoacyl-tRNA hydrolase activity
DTPSY_RS04080	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DTPSY_RS04085	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DTPSY_RS04105	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DTPSY_RS04120	COG1660	Displays ATPase and GTPase activities
DTPSY_RS04125	COG0497	DNA recombination
DTPSY_RS04130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DTPSY_RS04195	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DTPSY_RS04200	COG1420	regulation of RNA biosynthetic process
DTPSY_RS04210	COG0251	oxidation-reduction process
DTPSY_RS04245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DTPSY_RS04250	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DTPSY_RS04270	COG1561	YicC-like family, N-terminal region
DTPSY_RS04275	COG0194	GDP metabolic process
DTPSY_RS04280	COG1758	RNA polymerase activity
DTPSY_RS04285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DTPSY_RS04305	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DTPSY_RS04310	COG1185	polyribonucleotide nucleotidyltransferase activity
DTPSY_RS04315	COG0604	alcohol dehydrogenase
DTPSY_RS04315	COG3321	synthase
DTPSY_RS04315	COG1028	Short-chain dehydrogenase reductase Sdr
DTPSY_RS04320	COG0149	triose-phosphate isomerase activity
DTPSY_RS04335	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DTPSY_RS04340	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DTPSY_RS04345	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DTPSY_RS04350	COG0649	NAD binding
DTPSY_RS04365	COG1034	ATP synthesis coupled electron transport
DTPSY_RS04370	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DTPSY_RS04375	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DTPSY_RS04385	COG0713	ATP synthesis coupled electron transport
DTPSY_RS04400	COG1007	ATP synthesis coupled electron transport
DTPSY_RS04415	COG1132	(ABC) transporter
DTPSY_RS04425	COG4133	protoheme IX ABC transporter activity
DTPSY_RS04430	COG1280	lysine exporter protein (LysE YggA)
DTPSY_RS04435	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DTPSY_RS04440	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DTPSY_RS04450	COG0586	Pfam SNARE associated Golgi protein
DTPSY_RS04465	COG0860	N-Acetylmuramoyl-L-alanine amidase
DTPSY_RS04470	COG0802	atpase or kinase
DTPSY_RS04475	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DTPSY_RS04485	COG3181	Tripartite tricarboxylate transporter family receptor
DTPSY_RS04490	COG4974	Belongs to the 'phage' integrase family
DTPSY_RS04500	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DTPSY_RS04505	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DTPSY_RS04510	COG2833	Protein of unknown function (DUF455)
DTPSY_RS04520	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DTPSY_RS04530	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DTPSY_RS04535	COG0148	phosphopyruvate hydratase activity
DTPSY_RS04545	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DTPSY_RS04550	COG0504	CTP synthase activity
DTPSY_RS04555	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DTPSY_RS04560	COG0756	dUTP diphosphatase activity
DTPSY_RS04570	COG1047	Peptidyl-prolyl cis-trans
DTPSY_RS04575	COG2850	peptidyl-arginine hydroxylation
DTPSY_RS04590	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DTPSY_RS04595	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
DTPSY_RS04600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DTPSY_RS04610	COG2814	Major facilitator Superfamily
DTPSY_RS04620	COG0741	lytic transglycosylase activity
DTPSY_RS04630	COG0840	transmembrane signaling receptor activity
DTPSY_RS04645	COG2308	Evidence 4 Homologs of previously reported genes of
DTPSY_RS04660	COG4628	conserved protein (DUF2132)
DTPSY_RS04670	COG0657	acetylesterase activity
DTPSY_RS04695	COG4774	siderophore transport
DTPSY_RS04740	COG1722	exodeoxyribonuclease VII activity
DTPSY_RS04745	COG0142	geranyltranstransferase activity
DTPSY_RS04750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DTPSY_RS04755	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DTPSY_RS04760	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DTPSY_RS04770	COG0405	Gamma-glutamyltransferase
DTPSY_RS04775	COG3850	Histidine kinase
DTPSY_RS04775	COG2205	protein histidine kinase activity
DTPSY_RS04775	COG4999	Histidine kinase
DTPSY_RS04775	COG3437	response regulator, receiver
DTPSY_RS04785	COG0483	inositol monophosphate 1-phosphatase activity
DTPSY_RS04795	COG1045	serine acetyltransferase
DTPSY_RS04805	COG1063	alcohol dehydrogenase
DTPSY_RS04815	COG0521	Mo-molybdopterin cofactor biosynthetic process
DTPSY_RS04820	COG3028	Belongs to the UPF0307 family
DTPSY_RS04825	COG0312	modulator of DNA gyrase
DTPSY_RS04845	COG0114	fumarate hydratase activity
DTPSY_RS04855	COG0745	RESPONSE REGULATOR receiver
DTPSY_RS04860	COG2205	protein histidine kinase activity
DTPSY_RS04865	COG2113	Glycine betaine
DTPSY_RS04870	COG4176	ABC-type proline glycine betaine transport system permease component
DTPSY_RS04875	COG4175	Glycine betaine
DTPSY_RS04885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DTPSY_RS04895	COG4654	Cytochrome c, class I
DTPSY_RS04905	COG0129	dihydroxy-acid dehydratase activity
DTPSY_RS04910	COG0129	dihydroxy-acid dehydratase activity
DTPSY_RS04925	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DTPSY_RS04930	COG1802	Transcriptional regulator
DTPSY_RS04950	COG0318	PFAM AMP-dependent synthetase and ligase
DTPSY_RS04970	COG3278	Belongs to the heme-copper respiratory oxidase family
DTPSY_RS05005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DTPSY_RS05010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DTPSY_RS05030	COG4206	TonB-dependent receptor
DTPSY_RS05035	COG1797	cobyrinic acid a,c-diamide synthase activity
DTPSY_RS05050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DTPSY_RS05055	COG1120	ATPase activity
DTPSY_RS05065	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DTPSY_RS05085	COG4372	Transposase
DTPSY_RS05110	COG3038	cytochrome b561
DTPSY_RS05130	COG2814	Major facilitator Superfamily
DTPSY_RS05145	COG0280	phosphate acetyltransferase
DTPSY_RS05145	COG0281	malic enzyme
DTPSY_RS05150	COG2233	PERMEase
DTPSY_RS05170	COG2186	Transcriptional regulator
DTPSY_RS05175	COG0583	DNA-binding transcription factor activity
DTPSY_RS05210	COG1012	belongs to the aldehyde dehydrogenase family
DTPSY_RS05225	COG0402	S-adenosylhomocysteine deaminase activity
DTPSY_RS05230	COG0717	Belongs to the dCTP deaminase family
DTPSY_RS05235	COG2321	neutral zinc metallopeptidase
DTPSY_RS05240	COG0513	Belongs to the DEAD box helicase family
DTPSY_RS05255	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DTPSY_RS05270	COG3901	Regulator of nitric oxide reductase transcription
DTPSY_RS05270	COG0348	domain, Protein
DTPSY_RS05275	COG4263	nitrous-oxide reductase activity
DTPSY_RS05285	COG3245	cytochrome
DTPSY_RS05295	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DTPSY_RS05300	COG2916	Histone family protein nucleoid-structuring protein H-NS
DTPSY_RS05305	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DTPSY_RS05325	COG3275	phosphorelay sensor kinase activity
DTPSY_RS05335	COG1968	undecaprenyl-diphosphatase activity
DTPSY_RS05345	COG2267	carboxylic ester hydrolase activity
DTPSY_RS05355	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DTPSY_RS05360	COG3540	Alkaline phosphatase
DTPSY_RS05375	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DTPSY_RS05380	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DTPSY_RS05390	COG0564	pseudouridine synthase activity
DTPSY_RS05395	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DTPSY_RS05400	COG1187	pseudouridine synthase activity
DTPSY_RS05405	COG0105	UTP biosynthetic process
DTPSY_RS05410	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DTPSY_RS05430	COG0124	histidyl-tRNA synthetase
DTPSY_RS05445	COG1160	GTP binding
DTPSY_RS05450	COG1923	regulation of RNA biosynthetic process
DTPSY_RS05455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DTPSY_RS05460	COG0330	HflC and HflK could
DTPSY_RS05465	COG0330	HflC and HflK could
DTPSY_RS05475	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DTPSY_RS05480	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DTPSY_RS05525	COG0726	polysaccharide deacetylase
DTPSY_RS05545	COG0174	glutamine synthetase
DTPSY_RS05560	COG2204	response regulator
DTPSY_RS05570	COG0708	Exodeoxyribonuclease III
DTPSY_RS05580	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DTPSY_RS05585	COG0277	FAD linked oxidase domain protein
DTPSY_RS05595	COG1295	ribonuclease BN
DTPSY_RS05600	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DTPSY_RS05605	COG1562	ergosterol biosynthetic process
DTPSY_RS05630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DTPSY_RS05640	COG0544	peptidyl-prolyl cis-trans isomerase activity
DTPSY_RS05645	COG0740	serine-type endopeptidase activity
DTPSY_RS05650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DTPSY_RS05655	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DTPSY_RS05675	COG0582	viral genome integration into host DNA
DTPSY_RS05695	COG0633	Ferredoxin
DTPSY_RS05700	COG0789	Transcriptional regulator
DTPSY_RS05710	COG0640	Transcriptional regulator
DTPSY_RS05715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DTPSY_RS05745	COG1937	Protein conserved in bacteria
DTPSY_RS05750	COG2814	Major facilitator Superfamily
DTPSY_RS05755	COG1230	cation diffusion facilitator family transporter
DTPSY_RS05760	COG0640	Transcriptional regulator
DTPSY_RS05800	COG2814	Major facilitator Superfamily
DTPSY_RS05815	COG2814	Major facilitator Superfamily
DTPSY_RS05830	COG2186	Transcriptional regulator
DTPSY_RS05940	COG0322	excinuclease ABC activity
DTPSY_RS05960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DTPSY_RS05970	COG4372	Transposase
DTPSY_RS06015	COG0513	Belongs to the DEAD box helicase family
DTPSY_RS06020	COG0488	(ABC) transporter
DTPSY_RS06035	COG3191	aminopeptidase activity
DTPSY_RS06060	COG2132	Multicopper oxidase
DTPSY_RS06095	COG0789	Transcriptional regulator
DTPSY_RS06115	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DTPSY_RS06120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DTPSY_RS06130	COG0052	Belongs to the universal ribosomal protein uS2 family
DTPSY_RS06135	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DTPSY_RS06140	COG0528	UMP kinase activity
DTPSY_RS06145	COG0233	cytoplasmic translational termination
DTPSY_RS06150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DTPSY_RS06155	COG0575	Belongs to the CDS family
DTPSY_RS06160	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DTPSY_RS06165	COG0750	zinc metalloprotease
DTPSY_RS06180	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DTPSY_RS06185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DTPSY_RS06190	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DTPSY_RS06195	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DTPSY_RS06200	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DTPSY_RS06205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DTPSY_RS06225	COG0557	exoribonuclease II activity
DTPSY_RS06250	COG0779	Required for maturation of 30S ribosomal subunits
DTPSY_RS06255	COG0195	Participates in both transcription termination and antitermination
DTPSY_RS06260	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DTPSY_RS06265	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DTPSY_RS06270	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DTPSY_RS06285	COG1024	Enoyl-CoA hydratase
DTPSY_RS06305	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DTPSY_RS06310	COG2867	negative regulation of translational initiation
DTPSY_RS06330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DTPSY_RS06330	COG0519	Catalyzes the synthesis of GMP from XMP
DTPSY_RS06335	COG0582	viral genome integration into host DNA
DTPSY_RS06375	COG2003	Belongs to the UPF0758 family
DTPSY_RS06395	COG1475	DNA binding
DTPSY_RS06455	COG1192	Involved in chromosome partitioning
DTPSY_RS06480	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DTPSY_RS06500	COG1611	Belongs to the LOG family
DTPSY_RS06505	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DTPSY_RS06520	COG0842	Transport permease protein
DTPSY_RS06525	COG0842	Transport permease protein
DTPSY_RS06530	COG1131	(ABC) transporter
DTPSY_RS06535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DTPSY_RS06545	COG1309	transcriptional regulator
DTPSY_RS06560	COG1028	Short-chain dehydrogenase reductase Sdr
DTPSY_RS06565	COG0589	response to stress
DTPSY_RS06580	COG0583	DNA-binding transcription factor activity
DTPSY_RS06595	COG4962	Type ii secretion system protein e
DTPSY_RS06600	COG3838	Conjugal transfer protein Trbc
DTPSY_RS06610	COG3451	type IV secretory pathway VirB4
DTPSY_RS06625	COG3846	protein secretion by the type IV secretion system
DTPSY_RS06640	COG2948	multi-organism process
DTPSY_RS06715	COG1028	Short-chain dehydrogenase reductase Sdr
DTPSY_RS06720	COG2918	glutathione biosynthetic process
DTPSY_RS06730	COG0583	DNA-binding transcription factor activity
DTPSY_RS06740	COG0798	PFAM Bile acid sodium symporter
DTPSY_RS06775	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DTPSY_RS06795	COG1285	pathogenesis
DTPSY_RS06800	COG0564	pseudouridine synthase activity
DTPSY_RS06865	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DTPSY_RS06875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DTPSY_RS06890	COG1611	Belongs to the LOG family
DTPSY_RS06895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DTPSY_RS06935	COG2212	antiporter activity
DTPSY_RS06945	COG0651	ATP synthesis coupled electron transport
DTPSY_RS06950	COG1006	Multisubunit Na H antiporter MnhC subunit
DTPSY_RS06955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DTPSY_RS06955	COG2111	Na H antiporter
DTPSY_RS06965	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DTPSY_RS06975	COG0776	regulation of translation
DTPSY_RS06985	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DTPSY_RS06990	COG0287	Prephenate dehydrogenase
DTPSY_RS06995	COG0077	Prephenate dehydratase
DTPSY_RS06995	COG1605	Chorismate mutase
DTPSY_RS07000	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DTPSY_RS07015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DTPSY_RS07025	COG4372	Transposase
DTPSY_RS07040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DTPSY_RS07075	COG0640	Transcriptional regulator
DTPSY_RS07085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DTPSY_RS07090	COG0642	Histidine kinase
DTPSY_RS07120	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
DTPSY_RS07125	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DTPSY_RS07130	COG0583	DNA-binding transcription factor activity
DTPSY_RS07190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DTPSY_RS07200	COG0670	Belongs to the BI1 family
DTPSY_RS07205	COG3193	protein, possibly involved in utilization of glycolate and propanediol
DTPSY_RS07240	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DTPSY_RS07255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DTPSY_RS07260	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DTPSY_RS07265	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DTPSY_RS07270	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DTPSY_RS07275	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DTPSY_RS07280	COG0072	phenylalanine-tRNA ligase activity
DTPSY_RS07280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DTPSY_RS07285	COG0776	regulation of translation
DTPSY_RS07290	COG0789	Transcriptional regulator
DTPSY_RS07300	COG0505	Belongs to the CarA family
DTPSY_RS07310	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DTPSY_RS07345	COG0745	RESPONSE REGULATOR receiver
DTPSY_RS07350	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DTPSY_RS07355	COG0586	Pfam SNARE associated Golgi protein
DTPSY_RS07365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DTPSY_RS07385	COG1534	Rna-binding protein
DTPSY_RS07390	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DTPSY_RS07395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DTPSY_RS07405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DTPSY_RS07420	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DTPSY_RS07445	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DTPSY_RS07450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DTPSY_RS07455	COG0573	inorganic phosphate transmembrane transporter activity
DTPSY_RS07460	COG0581	inorganic phosphate transmembrane transporter activity
DTPSY_RS07465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DTPSY_RS07470	COG0704	Plays a role in the regulation of phosphate uptake
DTPSY_RS07475	COG0745	RESPONSE REGULATOR receiver
DTPSY_RS07485	COG0534	Mate efflux family protein
DTPSY_RS07495	COG0254	rRNA binding
DTPSY_RS07500	COG0842	Transport permease protein
DTPSY_RS07505	COG0842	Transport permease protein
DTPSY_RS07505	COG1129	ABC transporter
DTPSY_RS07510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DTPSY_RS07520	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DTPSY_RS07535	COG1074	ATP-dependent DNA helicase activity
DTPSY_RS07540	COG2226	methyltransferase
DTPSY_RS07545	COG0492	ferredoxin-NADP+ reductase activity
DTPSY_RS07555	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DTPSY_RS07560	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DTPSY_RS07565	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DTPSY_RS07580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DTPSY_RS07585	COG2011	ABC-type metal ion transport system permease component
DTPSY_RS07595	COG1464	Belongs to the NlpA lipoprotein family
DTPSY_RS07605	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DTPSY_RS07615	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DTPSY_RS07620	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DTPSY_RS07625	COG4208	sulfate ABC transporter
DTPSY_RS07630	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DTPSY_RS07635	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DTPSY_RS07650	COG4773	Receptor
DTPSY_RS07670	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DTPSY_RS07670	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DTPSY_RS07675	COG2755	lipolytic protein G-D-S-L family
DTPSY_RS07675	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DTPSY_RS07680	COG2963	transposase activity
DTPSY_RS07685	COG2801	Transposase and inactivated derivatives
DTPSY_RS07690	COG3181	Tripartite tricarboxylate transporter family receptor
DTPSY_RS07705	COG2814	Major facilitator Superfamily
DTPSY_RS07710	COG1122	ATPase activity
DTPSY_RS07720	COG1268	BioY protein
DTPSY_RS07725	COG0318	PFAM AMP-dependent synthetase and ligase
DTPSY_RS07730	COG0183	Belongs to the thiolase family
DTPSY_RS07740	COG1408	metallophosphoesterase
DTPSY_RS07750	COG1643	Atp-dependent helicase
DTPSY_RS07765	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DTPSY_RS07770	COG0252	asparaginase activity
DTPSY_RS07775	COG0563	adenylate kinase activity
DTPSY_RS07780	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DTPSY_RS07785	COG2835	tetraacyldisaccharide 4'-kinase activity
DTPSY_RS07790	COG1663	tetraacyldisaccharide 4'-kinase activity
DTPSY_RS07795	COG0848	biopolymer transport protein
DTPSY_RS07800	COG0811	peptide transport
DTPSY_RS07805	COG1570	exodeoxyribonuclease VII activity
DTPSY_RS07810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DTPSY_RS07890	COG0589	response to stress
DTPSY_RS07905	COG0582	viral genome integration into host DNA
DTPSY_RS07920	COG2832	Protein of unknown function (DUF454)
DTPSY_RS07925	COG0242	peptide deformylase activity
DTPSY_RS07940	COG0047	phosphoribosylformylglycinamidine synthase activity
DTPSY_RS07940	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DTPSY_RS07950	COG2354	Protein conserved in bacteria
DTPSY_RS07955	COG3047	cAMP biosynthetic process
DTPSY_RS07960	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DTPSY_RS07965	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DTPSY_RS07975	COG0826	peptidase U32
DTPSY_RS07980	COG0786	glutamate:sodium symporter activity
DTPSY_RS07995	COG1619	proteins homologs of microcin C7 resistance protein MccF
DTPSY_RS08010	COG1741	Belongs to the pirin family
DTPSY_RS08035	COG0626	cystathionine gamma-synthase activity
DTPSY_RS08050	COG4181	ATPase activity
DTPSY_RS08055	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DTPSY_RS08060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DTPSY_RS08080	COG5507	3-demethylubiquinone-9 3-methyltransferase
DTPSY_RS08090	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DTPSY_RS08095	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DTPSY_RS08110	COG0179	Fumarylacetoacetate (FAA) hydrolase
DTPSY_RS08130	COG0583	DNA-binding transcription factor activity
DTPSY_RS08135	COG3550	peptidyl-serine autophosphorylation
DTPSY_RS08145	COG0583	DNA-binding transcription factor activity
DTPSY_RS08150	COG3048	D-serine ammonia-lyase activity
DTPSY_RS08160	COG0154	amidase activity
DTPSY_RS08180	COG1739	Uncharacterized protein family UPF0029
DTPSY_RS08200	COG3384	dioxygenase
DTPSY_RS08210	COG0556	nucleotide-excision repair
DTPSY_RS08215	COG1959	2 iron, 2 sulfur cluster binding
DTPSY_RS08220	COG1104	cysteine desulfurase activity
DTPSY_RS08225	COG0822	iron-sulfur transferase activity
DTPSY_RS08240	COG0443	Heat shock 70 kDa protein
DTPSY_RS08245	COG0633	Ferredoxin
DTPSY_RS08250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DTPSY_RS08270	COG0579	oxidoreductase
DTPSY_RS08290	COG0167	dihydroorotate dehydrogenase activity
DTPSY_RS08295	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DTPSY_RS08310	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DTPSY_RS08315	COG4566	intracellular signal transduction
DTPSY_RS08330	COG0508	dehydrogenase complex catalyzes the overall conversion of
DTPSY_RS08335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DTPSY_RS08345	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DTPSY_RS08360	COG0791	NLP P60 protein
DTPSY_RS08365	COG2814	Major facilitator Superfamily
DTPSY_RS08370	COG1132	(ABC) transporter
DTPSY_RS08380	COG1742	UPF0060 membrane protein
DTPSY_RS08385	COG1196	nuclear chromosome segregation
DTPSY_RS08400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DTPSY_RS08405	COG1752	Esterase of the alpha-beta hydrolase superfamily
DTPSY_RS08410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DTPSY_RS08445	COG3243	poly(R)-hydroxyalkanoic acid synthase
DTPSY_RS08450	COG0183	Belongs to the thiolase family
DTPSY_RS08460	COG1309	transcriptional regulator
DTPSY_RS08475	COG1136	(ABC) transporter
DTPSY_RS08480	COG2951	lytic endotransglycosylase activity
DTPSY_RS08485	COG2925	Exonuclease
DTPSY_RS08495	COG3284	Transcriptional regulator
DTPSY_RS08510	COG1012	belongs to the aldehyde dehydrogenase family
DTPSY_RS08515	COG1283	sodium-dependent phosphate transmembrane transporter activity
DTPSY_RS08520	COG0628	permease
DTPSY_RS08525	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DTPSY_RS08540	COG0217	transcriptional regulatory protein
DTPSY_RS08545	COG0625	glutathione transferase activity
DTPSY_RS08550	COG0433	COG0433 Predicted ATPase
DTPSY_RS08555	COG0217	transcriptional regulatory protein
DTPSY_RS08560	COG0151	Belongs to the GarS family
DTPSY_RS08565	COG0408	coproporphyrinogen oxidase activity
DTPSY_RS08570	COG0799	negative regulation of ribosome biogenesis
DTPSY_RS08575	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DTPSY_RS08580	COG0424	maF-like protein
DTPSY_RS08595	COG0535	radical SAM domain protein
DTPSY_RS08610	COG1522	sequence-specific DNA binding
DTPSY_RS08615	COG3391	amine dehydrogenase activity
DTPSY_RS08620	COG2010	Cytochrome c
DTPSY_RS08630	COG1648	precorrin-2 dehydrogenase activity
DTPSY_RS08630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DTPSY_RS08640	COG0436	Aminotransferase
DTPSY_RS08645	COG0583	DNA-binding transcription factor activity
DTPSY_RS08665	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DTPSY_RS08685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DTPSY_RS08700	COG0589	response to stress
DTPSY_RS08705	COG3181	Tripartite tricarboxylate transporter family receptor
DTPSY_RS08710	COG0183	Belongs to the thiolase family
DTPSY_RS08715	COG1028	Short-chain dehydrogenase reductase Sdr
DTPSY_RS08730	COG0545	Peptidyl-prolyl cis-trans isomerase
DTPSY_RS08735	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DTPSY_RS08735	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DTPSY_RS08740	COG0509	glycine decarboxylation via glycine cleavage system
DTPSY_RS08745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DTPSY_RS08760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DTPSY_RS08785	COG4120	Belongs to the binding-protein-dependent transport system permease family
DTPSY_RS08805	COG0642	Histidine kinase
DTPSY_RS08810	COG0745	RESPONSE REGULATOR receiver
DTPSY_RS08835	COG0753	catalase activity
DTPSY_RS08840	COG1252	NADH dehydrogenase
DTPSY_RS08860	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DTPSY_RS08875	COG0587	DNA-directed DNA polymerase activity
DTPSY_RS08900	COG2197	response regulator
DTPSY_RS08910	COG2982	Protein involved in outer membrane biogenesis
DTPSY_RS08925	COG0564	pseudouridine synthase activity
DTPSY_RS08935	COG1012	belongs to the aldehyde dehydrogenase family
DTPSY_RS08940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DTPSY_RS08950	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DTPSY_RS08955	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DTPSY_RS08960	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DTPSY_RS08960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DTPSY_RS08965	COG0583	DNA-binding transcription factor activity
DTPSY_RS08970	COG1741	Belongs to the pirin family
DTPSY_RS08975	COG2259	Doxx family
DTPSY_RS08980	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DTPSY_RS08985	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DTPSY_RS08995	COG4948	Mandelate Racemase Muconate Lactonizing
DTPSY_RS09000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DTPSY_RS09010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DTPSY_RS09020	COG2186	Transcriptional regulator
DTPSY_RS09025	COG4948	Mandelate Racemase Muconate Lactonizing
DTPSY_RS09040	COG3171	Protein conserved in bacteria
DTPSY_RS09045	COG0133	tryptophan synthase activity
DTPSY_RS09105	COG1960	acyl-CoA dehydrogenase activity
DTPSY_RS09120	COG0583	DNA-binding transcription factor activity
DTPSY_RS09130	COG1028	Short-chain dehydrogenase reductase Sdr
DTPSY_RS09155	COG2133	pyrroloquinoline quinone binding
DTPSY_RS09200	COG1042	CoA-binding domain protein
DTPSY_RS09200	COG0045	succinate-CoA ligase (ADP-forming) activity
DTPSY_RS09200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DTPSY_RS09210	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DTPSY_RS09220	COG1054	Belongs to the UPF0176 family
DTPSY_RS09225	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DTPSY_RS09230	COG1309	transcriptional regulator
DTPSY_RS09235	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DTPSY_RS09275	COG1022	Amp-dependent synthetase and ligase
DTPSY_RS09280	COG1802	Transcriptional regulator
DTPSY_RS09285	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DTPSY_RS09285	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DTPSY_RS09290	COG1703	isobutyryl-CoA mutase activity
DTPSY_RS09295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DTPSY_RS09305	COG4770	biotin carboxylase activity
DTPSY_RS09315	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DTPSY_RS09360	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DTPSY_RS09390	COG1028	Short-chain dehydrogenase reductase Sdr
DTPSY_RS09395	COG0346	lactoylglutathione lyase activity
DTPSY_RS09400	COG0800	Aldolase
DTPSY_RS09410	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DTPSY_RS09415	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DTPSY_RS09420	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DTPSY_RS09425	COG3265	gluconokinase activity
DTPSY_RS09430	COG1609	Transcriptional regulator
DTPSY_RS09445	COG2032	superoxide dismutase activity
DTPSY_RS09450	COG0259	pyridoxamine-phosphate oxidase activity
DTPSY_RS09480	COG2878	Part of a membrane complex involved in electron transport
DTPSY_RS09495	COG2171	N-acyltransferase activity
DTPSY_RS09505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DTPSY_RS09510	COG2890	protein-(glutamine-N5) methyltransferase activity
DTPSY_RS09515	COG0488	(ABC) transporter
DTPSY_RS09520	COG1028	Short-chain dehydrogenase reductase Sdr
DTPSY_RS09525	COG0542	response to heat
DTPSY_RS09530	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DTPSY_RS09545	COG1199	ATP-dependent helicase activity
DTPSY_RS09550	COG0631	protein serine/threonine phosphatase activity
DTPSY_RS09560	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DTPSY_RS09565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DTPSY_RS09570	COG0508	dehydrogenase complex catalyzes the overall conversion of
DTPSY_RS09575	COG0567	Dehydrogenase, E1 component
DTPSY_RS09580	COG0628	permease
DTPSY_RS09605	COG0589	response to stress
DTPSY_RS09610	COG3622	Belongs to the hyi family
DTPSY_RS09620	COG4172	Belongs to the ABC transporter superfamily
DTPSY_RS09625	COG4239	(ABC) transporter, permease
DTPSY_RS09630	COG4174	ABC transporter (Permease)
DTPSY_RS09635	COG4166	transmembrane transport
DTPSY_RS09650	COG0415	Belongs to the DNA photolyase family
DTPSY_RS09655	COG0625	glutathione transferase activity
DTPSY_RS09660	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DTPSY_RS09665	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
DTPSY_RS09670	COG2860	membrane
DTPSY_RS09675	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DTPSY_RS09675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DTPSY_RS09690	COG0175	sulfate reduction
DTPSY_RS09695	COG0175	sulfate reduction
DTPSY_RS09700	COG2895	sulfate adenylyltransferase (ATP) activity
DTPSY_RS09705	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DTPSY_RS09710	COG0492	ferredoxin-NADP+ reductase activity
DTPSY_RS09720	COG0351	phosphomethylpyrimidine kinase
DTPSY_RS09735	COG2022	thiamine diphosphate biosynthetic process
DTPSY_RS09750	COG1250	3-hydroxyacyl-CoA dehydrogenase
DTPSY_RS09755	COG1024	Enoyl-CoA hydratase
DTPSY_RS09775	COG1414	Transcriptional regulator
DTPSY_RS09785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DTPSY_RS09795	COG1183	phosphatidylcholine synthase activity
DTPSY_RS09800	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DTPSY_RS09805	COG0440	acetolactate synthase activity
DTPSY_RS09810	COG0028	Belongs to the TPP enzyme family
DTPSY_RS09815	COG1595	DNA-templated transcription, initiation
DTPSY_RS09845	COG0347	Belongs to the P(II) protein family
DTPSY_RS09850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DTPSY_RS09850	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DTPSY_RS09860	COG0835	chemotaxis
DTPSY_RS09865	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DTPSY_RS09890	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DTPSY_RS09895	COG0746	molybdenum cofactor guanylyltransferase activity
DTPSY_RS09910	COG0328	RNA-DNA hybrid ribonuclease activity
DTPSY_RS09915	COG2226	methyltransferase
DTPSY_RS09920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DTPSY_RS09925	COG1388	LysM domain
DTPSY_RS09925	COG0741	lytic transglycosylase activity
DTPSY_RS09935	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
DTPSY_RS09945	COG0823	Involved in the tonB-independent uptake of proteins
DTPSY_RS09950	COG1132	(ABC) transporter
DTPSY_RS09960	COG0084	hydrolase, TatD family'
DTPSY_RS09970	COG0470	DNA polymerase III
DTPSY_RS09975	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DTPSY_RS09980	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DTPSY_RS09985	COG0354	folic acid binding
DTPSY_RS10025	COG2183	response to ionizing radiation
DTPSY_RS10040	COG2814	Major facilitator Superfamily
DTPSY_RS10045	COG2814	Major facilitator Superfamily
DTPSY_RS10065	COG2153	protein acetylation
DTPSY_RS10070	COG2130	NADP-dependent
DTPSY_RS10105	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
DTPSY_RS10110	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DTPSY_RS10115	COG3639	organic phosphonate transmembrane transporter activity
DTPSY_RS10130	COG1960	acyl-CoA dehydrogenase activity
DTPSY_RS10140	COG0183	Belongs to the thiolase family
DTPSY_RS10145	COG1024	Enoyl-CoA hydratase
DTPSY_RS10145	COG1250	3-hydroxyacyl-CoA dehydrogenase
DTPSY_RS10155	COG0411	ABC transporter
DTPSY_RS10165	COG0559	Belongs to the binding-protein-dependent transport system permease family
DTPSY_RS10175	COG0318	PFAM AMP-dependent synthetase and ligase
DTPSY_RS10180	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DTPSY_RS10185	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DTPSY_RS10190	COG2917	probably involved in intracellular septation
DTPSY_RS10200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DTPSY_RS10220	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DTPSY_RS10230	COG0688	phosphatidylethanolamine metabolic process
DTPSY_RS10255	COG0741	lytic transglycosylase activity
DTPSY_RS10260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DTPSY_RS10265	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DTPSY_RS10270	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DTPSY_RS10285	COG2267	carboxylic ester hydrolase activity
DTPSY_RS10300	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DTPSY_RS10305	COG1067	ATP-dependent peptidase activity
DTPSY_RS10395	COG3181	Tripartite tricarboxylate transporter family receptor
DTPSY_RS10410	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DTPSY_RS10420	COG1396	sequence-specific DNA binding
DTPSY_RS10420	COG3800	Transcriptional regulator
DTPSY_RS10450	COG0583	DNA-binding transcription factor activity
DTPSY_RS10455	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DTPSY_RS10470	COG0527	aspartate kinase activity
DTPSY_RS10475	COG0037	tRNA processing
DTPSY_RS10495	COG0215	cysteine-tRNA ligase activity
DTPSY_RS10515	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DTPSY_RS10520	COG3228	Belongs to the MtfA family
DTPSY_RS10530	COG1522	sequence-specific DNA binding
DTPSY_RS10545	COG3384	dioxygenase
DTPSY_RS10560	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DTPSY_RS10570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DTPSY_RS10575	COG1840	ABC-type Fe3 transport system, periplasmic component
DTPSY_RS10640	COG3328	transposase activity
DTPSY_RS10710	COG3300	MHYT domain
DTPSY_RS10710	COG5001	Diguanylate cyclase
DTPSY_RS10715	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DTPSY_RS10720	COG0517	IMP dehydrogenase activity
DTPSY_RS10720	COG0516	GMP reductase activity
DTPSY_RS10735	COG0640	Transcriptional regulator
DTPSY_RS10755	COG1929	Belongs to the glycerate kinase type-1 family
DTPSY_RS10760	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DTPSY_RS10775	COG0789	Transcriptional regulator
DTPSY_RS10815	COG3041	Addiction module toxin RelE StbE family
DTPSY_RS10820	COG3077	Addiction module antitoxin, RelB DinJ family
DTPSY_RS10865	COG2801	Transposase and inactivated derivatives
DTPSY_RS10930	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DTPSY_RS10950	COG3174	membrane
DTPSY_RS11020	COG5002	protein histidine kinase activity
DTPSY_RS11030	COG0640	Transcriptional regulator
DTPSY_RS11035	COG2226	methyltransferase
DTPSY_RS11070	COG2194	sulfuric ester hydrolase activity
DTPSY_RS11100	COG2963	transposase activity
DTPSY_RS11105	COG2801	Transposase and inactivated derivatives
DTPSY_RS11150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DTPSY_RS11165	COG1286	toxin biosynthetic process
DTPSY_RS11175	COG0285	dihydrofolate synthase activity
DTPSY_RS11180	COG1393	Belongs to the ArsC family
DTPSY_RS11190	COG3123	guanosine phosphorylase activity
DTPSY_RS11195	COG0137	argininosuccinate synthase activity
DTPSY_RS11200	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DTPSY_RS11205	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DTPSY_RS11210	COG1595	DNA-templated transcription, initiation
DTPSY_RS11215	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DTPSY_RS11220	COG0471	metal ion transport
DTPSY_RS11230	COG1666	GTP binding
DTPSY_RS11235	COG3577	Aspartyl protease
DTPSY_RS11245	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DTPSY_RS11255	COG0667	Aldo Keto reductase
DTPSY_RS11270	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DTPSY_RS11275	COG0308	aminopeptidase N
DTPSY_RS11280	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DTPSY_RS11290	COG1793	dna ligase
DTPSY_RS11320	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DTPSY_RS11325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DTPSY_RS11330	COG0436	Aminotransferase
DTPSY_RS11335	COG0824	Thioesterase
DTPSY_RS11355	COG0477	Major facilitator Superfamily
DTPSY_RS11365	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DTPSY_RS11370	COG1845	cytochrome c oxidase, subunit III
DTPSY_RS11375	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DTPSY_RS11390	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DTPSY_RS11400	COG0826	peptidase U32
DTPSY_RS11435	COG4106	trans-aconitate 2-methyltransferase activity
DTPSY_RS11440	COG0039	L-malate dehydrogenase activity
DTPSY_RS11445	COG2188	Transcriptional regulator
DTPSY_RS11460	COG1053	succinate dehydrogenase
DTPSY_RS11465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DTPSY_RS11470	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DTPSY_RS11475	COG0372	Belongs to the citrate synthase family
DTPSY_RS11485	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DTPSY_RS11490	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DTPSY_RS11505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DTPSY_RS11520	COG1960	acyl-CoA dehydrogenase activity
DTPSY_RS11535	COG1511	domain protein
DTPSY_RS11535	COG3264	Mechanosensitive ion channel
DTPSY_RS11540	COG1024	Enoyl-CoA hydratase
DTPSY_RS11545	COG0123	including yeast histone deacetylase and acetoin utilization protein
DTPSY_RS11550	COG0714	Associated with various cellular activities
DTPSY_RS11565	COG2951	lytic endotransglycosylase activity
DTPSY_RS11570	COG0583	DNA-binding transcription factor activity
DTPSY_RS11580	COG0683	leucine binding
DTPSY_RS11595	COG1136	(ABC) transporter
DTPSY_RS11595	COG0577	efflux transmembrane transporter activity
DTPSY_RS11600	COG0577	efflux transmembrane transporter activity
DTPSY_RS11600	COG1136	(ABC) transporter
DTPSY_RS11605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DTPSY_RS11610	COG1538	Outer membrane efflux protein
DTPSY_RS11620	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DTPSY_RS11635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DTPSY_RS11640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DTPSY_RS11645	COG1116	anion transmembrane transporter activity
DTPSY_RS11650	COG0517	IMP dehydrogenase activity
DTPSY_RS11650	COG0516	GMP reductase activity
DTPSY_RS11665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DTPSY_RS11675	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DTPSY_RS11680	COG2146	nitrite reductase [NAD(P)H] activity
DTPSY_RS11685	COG0243	molybdopterin cofactor binding
DTPSY_RS11690	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DTPSY_RS11700	COG1607	acyl-coa hydrolase
DTPSY_RS11710	COG2081	HI0933 family
DTPSY_RS11730	COG0822	iron-sulfur transferase activity
DTPSY_RS11735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DTPSY_RS11745	COG0396	ATPase activity
DTPSY_RS11750	COG0719	Fe-S assembly protein
DTPSY_RS11755	COG0640	Transcriptional regulator
DTPSY_RS11770	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DTPSY_RS11775	COG1610	YqeY-like protein
DTPSY_RS11780	COG0473	3-isopropylmalate dehydrogenase activity
DTPSY_RS11790	COG1230	cation diffusion facilitator family transporter
DTPSY_RS11805	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DTPSY_RS11810	COG1451	nucleotide metabolic process
DTPSY_RS11825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DTPSY_RS11830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DTPSY_RS11835	COG0583	DNA-binding transcription factor activity
DTPSY_RS11845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DTPSY_RS11855	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DTPSY_RS11870	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DTPSY_RS11910	COG1289	transmembrane transporter activity
DTPSY_RS11915	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DTPSY_RS11920	COG0181	hydroxymethylbilane synthase activity
DTPSY_RS11945	COG0525	valine-tRNA ligase activity
DTPSY_RS11955	COG0425	Belongs to the sulfur carrier protein TusA family
DTPSY_RS11960	COG2816	NAD+ diphosphatase activity
DTPSY_RS11980	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DTPSY_RS11985	COG0724	RNA recognition motif
DTPSY_RS11995	COG0300	oxidoreductase activity
DTPSY_RS12015	COG0840	transmembrane signaling receptor activity
DTPSY_RS12020	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DTPSY_RS12030	COG1231	oxidoreductase activity
DTPSY_RS12040	COG3040	lipid binding
DTPSY_RS12055	COG1346	cytolysis
DTPSY_RS12060	COG0583	DNA-binding transcription factor activity
DTPSY_RS12065	COG1960	acyl-CoA dehydrogenase activity
DTPSY_RS12070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DTPSY_RS12120	COG0617	tRNA 3'-terminal CCA addition
DTPSY_RS12130	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DTPSY_RS12135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DTPSY_RS12145	COG0589	response to stress
DTPSY_RS12160	COG0728	peptidoglycan biosynthetic process
DTPSY_RS12165	COG0268	Binds directly to 16S ribosomal RNA
DTPSY_RS12175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DTPSY_RS12180	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DTPSY_RS12205	COG0727	PFAM Uncharacterised protein family (UPF0153)
DTPSY_RS12210	COG1522	sequence-specific DNA binding
DTPSY_RS12215	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DTPSY_RS12225	COG3483	tryptophan 2,3-dioxygenase activity
DTPSY_RS12230	COG2366	antibiotic biosynthetic process
DTPSY_RS12235	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DTPSY_RS12255	COG4603	Belongs to the binding-protein-dependent transport system permease family
DTPSY_RS12260	COG3845	ABC transporter
DTPSY_RS12270	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DTPSY_RS12275	COG5001	Diguanylate cyclase
DTPSY_RS12275	COG3447	MASE1 domain protein
DTPSY_RS12275	COG5002	protein histidine kinase activity
DTPSY_RS12285	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DTPSY_RS12290	COG5001	Diguanylate cyclase
DTPSY_RS12290	COG3300	MHYT domain
DTPSY_RS12295	COG0537	adenosine 5'-monophosphoramidase activity
DTPSY_RS12300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DTPSY_RS12305	COG2814	Major facilitator Superfamily
DTPSY_RS12310	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DTPSY_RS12315	COG1136	(ABC) transporter
DTPSY_RS12320	COG0071	Belongs to the small heat shock protein (HSP20) family
DTPSY_RS12385	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DTPSY_RS12400	COG1122	ATPase activity
DTPSY_RS12425	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DTPSY_RS12435	COG2814	Major facilitator Superfamily
DTPSY_RS12440	COG0318	PFAM AMP-dependent synthetase and ligase
DTPSY_RS12450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DTPSY_RS12455	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DTPSY_RS12475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DTPSY_RS12480	COG0583	DNA-binding transcription factor activity
DTPSY_RS12495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DTPSY_RS12500	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
DTPSY_RS12510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DTPSY_RS12520	COG1028	Short-chain dehydrogenase reductase Sdr
DTPSY_RS12540	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DTPSY_RS12540	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DTPSY_RS12545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DTPSY_RS12545	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DTPSY_RS12550	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DTPSY_RS12560	COG0560	Phosphoserine phosphatase
DTPSY_RS12575	COG0583	DNA-binding transcription factor activity
DTPSY_RS12580	COG1959	2 iron, 2 sulfur cluster binding
DTPSY_RS12600	COG0667	Aldo Keto reductase
DTPSY_RS12605	COG2900	Belongs to the SlyX family
DTPSY_RS12610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DTPSY_RS12615	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DTPSY_RS12645	COG4372	Transposase
DTPSY_RS12655	COG1215	transferase activity, transferring glycosyl groups
DTPSY_RS12665	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DTPSY_RS12670	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DTPSY_RS12675	COG0778	Nitroreductase
DTPSY_RS12680	COG1492	cobalamin metabolic process
DTPSY_RS12700	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DTPSY_RS12740	COG4636	protein conserved in cyanobacteria
DTPSY_RS12745	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DTPSY_RS12745	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DTPSY_RS12750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DTPSY_RS12785	COG0542	response to heat
DTPSY_RS12790	COG0314	molybdopterin synthase activity
DTPSY_RS12810	COG0303	'Molybdopterin
DTPSY_RS12815	COG1763	Mo-molybdopterin cofactor biosynthetic process
DTPSY_RS12830	COG0436	Aminotransferase
DTPSY_RS12840	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DTPSY_RS12845	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DTPSY_RS12860	COG0359	binds to the 23S rRNA
DTPSY_RS12865	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DTPSY_RS12870	COG2965	DNA replication, synthesis of RNA primer
DTPSY_RS12875	COG0360	Binds together with S18 to 16S ribosomal RNA
DTPSY_RS12880	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DTPSY_RS12885	COG0443	Heat shock 70 kDa protein
DTPSY_RS12890	COG0484	heat shock protein binding
DTPSY_RS12895	COG0826	peptidase U32
DTPSY_RS12900	COG0826	peptidase U32
DTPSY_RS12905	COG3154	lipid carrier protein
DTPSY_RS12920	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DTPSY_RS12930	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DTPSY_RS12940	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DTPSY_RS12955	COG0066	3-isopropylmalate dehydratase activity
DTPSY_RS12960	COG0473	3-isopropylmalate dehydrogenase activity
DTPSY_RS12970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DTPSY_RS12980	COG0101	tRNA pseudouridine synthase activity
DTPSY_RS12985	COG0135	phosphoribosylanthranilate isomerase activity
DTPSY_RS12990	COG0133	tryptophan synthase activity
DTPSY_RS12995	COG0159	tryptophan synthase activity
DTPSY_RS13000	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DTPSY_RS13005	COG0762	integral membrane protein
DTPSY_RS13015	COG0438	transferase activity, transferring glycosyl groups
DTPSY_RS13020	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DTPSY_RS13045	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DTPSY_RS13050	COG0745	RESPONSE REGULATOR receiver
DTPSY_RS13090	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DTPSY_RS13100	COG1472	Belongs to the glycosyl hydrolase 3 family
DTPSY_RS13105	COG0736	holo-[acyl-carrier-protein] synthase activity
DTPSY_RS13110	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DTPSY_RS13115	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
DTPSY_RS13120	COG1381	Involved in DNA repair and RecF pathway recombination
DTPSY_RS13125	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DTPSY_RS13130	COG0571	ribonuclease III activity
DTPSY_RS13140	COG0681	Belongs to the peptidase S26 family
DTPSY_RS13145	COG0481	GTPase activity
DTPSY_RS13150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DTPSY_RS13175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DTPSY_RS13180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DTPSY_RS13185	COG1028	Short-chain dehydrogenase reductase Sdr
DTPSY_RS13190	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DTPSY_RS13195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DTPSY_RS13200	COG0416	fatty acid biosynthetic process
DTPSY_RS13205	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DTPSY_RS13210	COG1399	metal-binding, possibly nucleic acid-binding protein
DTPSY_RS13215	COG0424	maF-like protein
DTPSY_RS13225	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DTPSY_RS13225	COG0616	signal peptide processing
DTPSY_RS13240	COG0564	pseudouridine synthase activity
DTPSY_RS13245	COG1530	ribonuclease E activity
DTPSY_RS13250	COG3022	response to hydroperoxide
DTPSY_RS13265	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DTPSY_RS13265	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DTPSY_RS13270	COG0840	transmembrane signaling receptor activity
DTPSY_RS13275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DTPSY_RS13285	COG1304	FMN binding
DTPSY_RS13315	COG0395	ABC-type sugar transport system, permease component
DTPSY_RS13320	COG1175	transmembrane transport
DTPSY_RS13330	COG3842	ATPase activity
DTPSY_RS13340	COG0753	catalase activity
DTPSY_RS13350	COG0165	Argininosuccinate lyase
DTPSY_RS13355	COG3275	phosphorelay sensor kinase activity
DTPSY_RS13370	COG0412	Dienelactone hydrolase
DTPSY_RS13390	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DTPSY_RS13405	COG2885	chlorophyll binding
DTPSY_RS13415	COG0210	DNA helicase
DTPSY_RS13425	COG0516	GMP reductase activity
DTPSY_RS13440	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DTPSY_RS13460	COG1429	ligase activity, forming nitrogen-metal bonds
DTPSY_RS13465	COG4771	TonB-dependent receptor
DTPSY_RS13495	COG2814	Major facilitator Superfamily
DTPSY_RS13500	COG0513	Belongs to the DEAD box helicase family
DTPSY_RS13505	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DTPSY_RS13510	COG0501	Belongs to the peptidase M48B family
DTPSY_RS13515	COG2154	pterin-4-alpha-carbinolamine dehydratase
DTPSY_RS13520	COG1162	GTPase activity
DTPSY_RS13525	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DTPSY_RS13530	COG0494	nUDIX hydrolase
DTPSY_RS13535	COG0335	large ribosomal subunit rRNA binding
DTPSY_RS13540	COG0336	Belongs to the RNA methyltransferase TrmD family
DTPSY_RS13545	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DTPSY_RS13550	COG0228	four-way junction DNA binding
DTPSY_RS13565	COG0306	phosphate transporter
DTPSY_RS13570	COG1392	Phosphate transport regulator
DTPSY_RS13585	COG0411	ABC transporter
DTPSY_RS13595	COG0559	Belongs to the binding-protein-dependent transport system permease family
DTPSY_RS13600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DTPSY_RS13615	COG1573	uracil-dna glycosylase
DTPSY_RS13620	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DTPSY_RS13625	COG1674	ftsk spoiiie
DTPSY_RS13630	COG0492	ferredoxin-NADP+ reductase activity
DTPSY_RS13635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DTPSY_RS13640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DTPSY_RS13650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DTPSY_RS13650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DTPSY_RS13670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DTPSY_RS13675	COG3132	Protein of unknown function, DUF480
DTPSY_RS13680	COG1960	acyl-CoA dehydrogenase activity
DTPSY_RS13685	COG1960	acyl-CoA dehydrogenase activity
DTPSY_RS13695	COG0196	riboflavin kinase activity
DTPSY_RS13705	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DTPSY_RS13710	COG1283	sodium-dependent phosphate transmembrane transporter activity
DTPSY_RS13730	COG0697	spore germination
DTPSY_RS13745	COG1028	Short-chain dehydrogenase reductase Sdr
DTPSY_RS13760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DTPSY_RS13765	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DTPSY_RS13775	COG0084	hydrolase, TatD family'
DTPSY_RS13785	COG0640	Transcriptional regulator
DTPSY_RS13795	COG1136	(ABC) transporter
DTPSY_RS13800	COG4591	ABC-type transport system involved in lipoprotein release permease component
DTPSY_RS13805	COG0584	glycerophosphoryl diester phosphodiesterase
DTPSY_RS13815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DTPSY_RS13835	COG0840	transmembrane signaling receptor activity
DTPSY_RS13840	COG0613	PHP domain protein
DTPSY_RS13845	COG0009	L-threonylcarbamoyladenylate synthase
DTPSY_RS13855	COG0714	Associated with various cellular activities
DTPSY_RS13860	COG3256	nitric oxide reductase
DTPSY_RS13865	COG2010	Cytochrome c
DTPSY_RS13870	COG1994	Peptidase M50
DTPSY_RS13875	COG0180	Tryptophanyl-tRNA synthetase
DTPSY_RS13885	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DTPSY_RS13890	COG0617	tRNA 3'-terminal CCA addition
DTPSY_RS13890	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DTPSY_RS13890	COG0517	IMP dehydrogenase activity
DTPSY_RS13895	COG1253	flavin adenine dinucleotide binding
DTPSY_RS13900	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DTPSY_RS13905	COG1047	Peptidyl-prolyl cis-trans
DTPSY_RS13910	COG2003	Belongs to the UPF0758 family
DTPSY_RS13920	COG1193	negative regulation of DNA recombination
DTPSY_RS13950	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DTPSY_RS13955	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DTPSY_RS13975	COG0437	4 iron, 4 sulfur cluster binding
DTPSY_RS13980	COG0243	molybdopterin cofactor binding
DTPSY_RS13980	COG3383	formate dehydrogenase (NAD+) activity
DTPSY_RS14010	COG3383	formate dehydrogenase (NAD+) activity
DTPSY_RS14025	COG0489	protein tyrosine kinase activity
DTPSY_RS14040	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
DTPSY_RS14055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DTPSY_RS14055	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DTPSY_RS14080	COG0028	Belongs to the TPP enzyme family
DTPSY_RS14105	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DTPSY_RS14110	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DTPSY_RS14125	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DTPSY_RS14135	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DTPSY_RS14140	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DTPSY_RS14145	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DTPSY_RS14150	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DTPSY_RS14160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DTPSY_RS14165	COG0588	phosphoglycerate mutase activity
DTPSY_RS14170	COG0793	Belongs to the peptidase S41A family
DTPSY_RS14175	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DTPSY_RS14185	COG2197	response regulator
DTPSY_RS14195	COG5487	UPF0391 membrane protein
DTPSY_RS14220	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DTPSY_RS14225	COG0742	ribosomal rna small subunit methyltransferase
DTPSY_RS14230	COG0612	Peptidase, M16
DTPSY_RS14235	COG0612	Peptidase, M16
DTPSY_RS14250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DTPSY_RS14255	COG3181	Tripartite tricarboxylate transporter family receptor
DTPSY_RS14270	COG1999	signal sequence binding
DTPSY_RS14275	COG0109	protoheme IX farnesyltransferase activity
DTPSY_RS14310	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DTPSY_RS14315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DTPSY_RS14325	COG2226	methyltransferase
DTPSY_RS14330	COG1040	competence protein
DTPSY_RS14335	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DTPSY_RS14345	COG1192	Involved in chromosome partitioning
DTPSY_RS14350	COG1280	lysine exporter protein (LysE YggA)
DTPSY_RS14355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DTPSY_RS14355	COG0475	glutathione-regulated potassium exporter activity
DTPSY_RS14365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DTPSY_RS14370	COG0183	Belongs to the thiolase family
DTPSY_RS14375	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DTPSY_RS14385	COG1414	Transcriptional regulator
DTPSY_RS14460	COG1178	ABC-type Fe3 transport system permease component
DTPSY_RS14465	COG3842	ATPase activity
DTPSY_RS14485	COG0540	Belongs to the ATCase OTCase family
DTPSY_RS14490	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DTPSY_RS14495	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DTPSY_RS14500	COG1678	Uncharacterized ACR, COG1678
DTPSY_RS14505	COG2198	Histidine kinase
DTPSY_RS14505	COG0643	Histidine kinase
DTPSY_RS14510	COG0840	transmembrane signaling receptor activity
DTPSY_RS14535	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DTPSY_RS14545	COG4654	Cytochrome c, class I
DTPSY_RS14550	COG0138	bifunctional purine biosynthesis protein purh
DTPSY_RS14555	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DTPSY_RS14560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DTPSY_RS14565	COG1238	metal cluster binding
DTPSY_RS14575	COG3181	Tripartite tricarboxylate transporter family receptor
DTPSY_RS14580	COG1473	amidohydrolase
DTPSY_RS14585	COG3639	organic phosphonate transmembrane transporter activity
DTPSY_RS14590	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
DTPSY_RS14595	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DTPSY_RS14600	COG3454	Phosphonate metabolism
DTPSY_RS14605	COG4778	phosphonate C-P lyase system protein PhnL
DTPSY_RS14610	COG4107	phosphonate C-P lyase system protein PhnK
DTPSY_RS14620	COG3627	carbon phosphorus lyase activity
DTPSY_RS14625	COG3626	phosphonate metabolism
DTPSY_RS14640	COG2188	Transcriptional regulator
DTPSY_RS14645	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
DTPSY_RS14655	COG0012	GTP binding
DTPSY_RS14660	COG0633	Ferredoxin
DTPSY_RS14660	COG3217	Mosc domain protein beta barrel domain protein
DTPSY_RS14665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DTPSY_RS14680	COG1024	Enoyl-CoA hydratase
DTPSY_RS14695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DTPSY_RS14700	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DTPSY_RS14705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DTPSY_RS14730	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DTPSY_RS14730	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DTPSY_RS14735	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DTPSY_RS14745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DTPSY_RS14755	COG2264	protein methyltransferase activity
DTPSY_RS14760	COG0439	Biotin carboxylase
DTPSY_RS14765	COG0511	ligase activity, forming carbon-carbon bonds
DTPSY_RS14770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DTPSY_RS14780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DTPSY_RS14790	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DTPSY_RS14800	COG0312	modulator of DNA gyrase
DTPSY_RS14805	COG0772	Belongs to the SEDS family
DTPSY_RS14815	COG3150	esterase
DTPSY_RS14825	COG3474	cytochrome
DTPSY_RS14840	COG0557	exoribonuclease II activity
DTPSY_RS14850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DTPSY_RS14855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DTPSY_RS14860	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DTPSY_RS14865	COG0840	transmembrane signaling receptor activity
DTPSY_RS14870	COG0840	transmembrane signaling receptor activity
DTPSY_RS14875	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DTPSY_RS14880	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DTPSY_RS14885	COG0840	transmembrane signaling receptor activity
DTPSY_RS14900	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DTPSY_RS14905	COG1181	Belongs to the D-alanine--D-alanine ligase family
DTPSY_RS14910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DTPSY_RS14915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DTPSY_RS14920	COG0772	Belongs to the SEDS family
DTPSY_RS14925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DTPSY_RS14930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DTPSY_RS14935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DTPSY_RS14940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DTPSY_RS14950	COG3116	cell division
DTPSY_RS14955	COG0275	rRNA processing
DTPSY_RS14960	COG2001	Belongs to the MraZ family
DTPSY_RS14965	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DTPSY_RS14970	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DTPSY_RS14985	COG0523	cobalamin synthesis protein
DTPSY_RS14995	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DTPSY_RS15005	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DTPSY_RS15020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DTPSY_RS15035	COG0501	Belongs to the peptidase M48B family
DTPSY_RS15045	COG3568	Endonuclease Exonuclease Phosphatase
DTPSY_RS15050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DTPSY_RS15060	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DTPSY_RS15085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DTPSY_RS15090	COG1024	Enoyl-CoA hydratase
DTPSY_RS15095	COG1960	acyl-CoA dehydrogenase activity
DTPSY_RS15100	COG1960	acyl-CoA dehydrogenase activity
DTPSY_RS15105	COG0183	Belongs to the thiolase family
DTPSY_RS15110	COG1024	Enoyl-CoA hydratase
DTPSY_RS15110	COG1250	3-hydroxyacyl-CoA dehydrogenase
DTPSY_RS15115	COG0583	DNA-binding transcription factor activity
DTPSY_RS15125	COG0501	Belongs to the peptidase M48B family
DTPSY_RS15140	COG0418	dihydroorotase activity
DTPSY_RS15150	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DTPSY_RS15155	COG0683	leucine binding
DTPSY_RS15160	COG0683	leucine binding
DTPSY_RS15175	COG0477	Major facilitator Superfamily
DTPSY_RS15205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DTPSY_RS15210	COG4770	biotin carboxylase activity
DTPSY_RS15220	COG1024	Enoyl-CoA hydratase
DTPSY_RS15225	COG2318	DinB family
DTPSY_RS15230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DTPSY_RS15235	COG0318	PFAM AMP-dependent synthetase and ligase
DTPSY_RS15245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DTPSY_RS15250	COG2203	Gaf domain
DTPSY_RS15250	COG3706	GGDEF domain
DTPSY_RS15250	COG5001	Diguanylate cyclase
DTPSY_RS15250	COG4251	negative regulation of phosphorylation
DTPSY_RS15255	COG0747	negative chemotaxis
DTPSY_RS15260	COG3012	SEC-C Motif Domain Protein
DTPSY_RS15270	COG1960	acyl-CoA dehydrogenase activity
DTPSY_RS15275	COG0300	oxidoreductase activity
DTPSY_RS15280	COG0183	Belongs to the thiolase family
DTPSY_RS15285	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
DTPSY_RS15290	COG0288	reversible hydration of carbon dioxide
DTPSY_RS15295	COG1960	acyl-CoA dehydrogenase activity
DTPSY_RS15300	COG0789	Transcriptional regulator
DTPSY_RS15330	COG0488	(ABC) transporter
DTPSY_RS15335	COG2201	protein-glutamate methylesterase activity
DTPSY_RS15340	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DTPSY_RS15350	COG0835	chemotaxis
DTPSY_RS15355	COG0643	Histidine kinase
DTPSY_RS15355	COG2198	Histidine kinase
DTPSY_RS15360	COG2201	protein-glutamate methylesterase activity
DTPSY_RS15375	COG2197	response regulator
DTPSY_RS15385	COG1987	bacterial-type flagellum assembly
DTPSY_RS15400	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DTPSY_RS15440	COG1766	The M ring may be actively involved in energy transduction
DTPSY_RS15445	COG1677	Flagellar hook-basal body complex protein FliE
DTPSY_RS15485	COG0745	RESPONSE REGULATOR receiver
DTPSY_RS15490	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
DTPSY_RS15500	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DTPSY_RS15515	COG1191	sigma factor activity
DTPSY_RS15535	COG1815	bacterial-type flagellum-dependent cell motility
DTPSY_RS15540	COG1558	bacterial-type flagellum-dependent cell motility
DTPSY_RS15545	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DTPSY_RS15565	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DTPSY_RS15575	COG1706	bacterial-type flagellum-dependent cell motility
DTPSY_RS15580	COG3951	Flagellar rod assembly protein muramidase FlgJ
DTPSY_RS15580	COG1705	Flagellar rod assembly protein muramidase FlgJ
DTPSY_RS15590	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DTPSY_RS15600	COG0733	neurotransmitter:sodium symporter activity
DTPSY_RS15605	COG2070	2-Nitropropane dioxygenase
DTPSY_RS15610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DTPSY_RS15620	COG0697	spore germination
DTPSY_RS15625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DTPSY_RS15630	COG0384	phenazine biosynthesis protein PhzF
DTPSY_RS15635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DTPSY_RS15665	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DTPSY_RS15670	COG4232	protein-disulfide reductase activity
DTPSY_RS15680	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DTPSY_RS15685	COG1832	CoA-binding protein
DTPSY_RS15695	COG0861	Integral membrane protein TerC family
DTPSY_RS15700	COG0583	DNA-binding transcription factor activity
DTPSY_RS15705	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DTPSY_RS15710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DTPSY_RS15720	COG0679	Auxin Efflux Carrier
DTPSY_RS15725	COG0210	DNA helicase
DTPSY_RS15745	COG0589	response to stress
DTPSY_RS15750	COG0343	queuine tRNA-ribosyltransferase activity
DTPSY_RS15780	COG1522	sequence-specific DNA binding
DTPSY_RS15785	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DTPSY_RS15790	COG0204	Acyl-transferase
DTPSY_RS15790	COG0318	PFAM AMP-dependent synthetase and ligase
DTPSY_RS15810	COG3181	Tripartite tricarboxylate transporter family receptor
DTPSY_RS15815	COG2072	flavoprotein involved in K transport
DTPSY_RS15825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DTPSY_RS15845	COG2365	Tyrosine phosphatase family
DTPSY_RS15855	COG3328	transposase activity
DTPSY_RS15905	COG2801	Transposase and inactivated derivatives
DTPSY_RS15910	COG2963	transposase activity
DTPSY_RS15930	COG2255	four-way junction helicase activity
DTPSY_RS16050	COG0616	signal peptide processing
DTPSY_RS16095	COG1475	DNA binding
DTPSY_RS16175	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DTPSY_RS16200	COG1396	sequence-specific DNA binding
DTPSY_RS16225	COG2204	response regulator
DTPSY_RS16230	COG5000	phosphorelay sensor kinase activity
DTPSY_RS16240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DTPSY_RS16240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DTPSY_RS16250	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DTPSY_RS16255	COG0085	RNA polymerase activity
DTPSY_RS16260	COG0222	ribosome binding
DTPSY_RS16265	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DTPSY_RS16270	COG0081	regulation of translation
DTPSY_RS16275	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DTPSY_RS16285	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DTPSY_RS16295	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DTPSY_RS16350	COG0189	ligase activity
DTPSY_RS16355	COG3135	benzoate transporter
DTPSY_RS16360	COG3158	transport of potassium into the cell
DTPSY_RS16370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DTPSY_RS16375	COG0569	domain protein
DTPSY_RS16380	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DTPSY_RS16400	COG0495	leucyl-tRNA aminoacylation
DTPSY_RS16405	COG0668	transmembrane transport
DTPSY_RS16420	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DTPSY_RS16425	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DTPSY_RS16430	COG0735	belongs to the Fur family
DTPSY_RS16435	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DTPSY_RS16445	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DTPSY_RS16450	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DTPSY_RS16465	COG3118	belongs to the thioredoxin family
DTPSY_RS16470	COG0693	protein deglycase activity
DTPSY_RS16485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DTPSY_RS16490	COG0009	L-threonylcarbamoyladenylate synthase
DTPSY_RS16510	COG2027	D-alanyl-D-alanine carboxypeptidase
DTPSY_RS16530	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DTPSY_RS16535	COG2414	aldehyde ferredoxin oxidoreductase
DTPSY_RS16560	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DTPSY_RS16565	COG0318	PFAM AMP-dependent synthetase and ligase
DTPSY_RS16595	COG0469	pyruvate kinase activity
DTPSY_RS16600	COG0006	proline dipeptidase activity
DTPSY_RS16615	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DTPSY_RS16620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DTPSY_RS16635	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DTPSY_RS16640	COG1047	Peptidyl-prolyl cis-trans
DTPSY_RS16660	COG1028	Short-chain dehydrogenase reductase Sdr
DTPSY_RS16670	COG3148	PFAM DTW domain containing protein
DTPSY_RS16700	COG0625	glutathione transferase activity
DTPSY_RS16705	COG2801	Transposase and inactivated derivatives
DTPSY_RS16725	COG3328	transposase activity
DTPSY_RS16775	COG3181	Tripartite tricarboxylate transporter family receptor
DTPSY_RS16780	COG0583	DNA-binding transcription factor activity
DTPSY_RS16785	COG0642	Histidine kinase
DTPSY_RS16800	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DTPSY_RS16805	COG2137	regulation of response to DNA damage stimulus
DTPSY_RS16815	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DTPSY_RS16820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DTPSY_RS16825	COG1862	Preprotein translocase
DTPSY_RS16830	COG0668	transmembrane transport
DTPSY_RS16840	COG1522	sequence-specific DNA binding
DTPSY_RS16855	COG2814	Major facilitator Superfamily
DTPSY_RS16860	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DTPSY_RS16870	COG4566	intracellular signal transduction
DTPSY_RS16890	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DTPSY_RS16905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DTPSY_RS16920	COG0625	glutathione transferase activity
DTPSY_RS16945	COG0861	Integral membrane protein TerC family
DTPSY_RS16955	COG1950	PFAM Membrane protein of
DTPSY_RS16960	COG4783	chaperone-mediated protein folding
DTPSY_RS16965	COG0315	cyclic pyranopterin monophosphate synthase activity
DTPSY_RS16975	COG4969	Belongs to the N-Me-Phe pilin family
DTPSY_RS16980	COG1716	ATPase activity
DTPSY_RS16990	COG0861	Integral membrane protein TerC family
DTPSY_RS16995	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DTPSY_RS17000	COG0045	succinate-CoA ligase (ADP-forming) activity
DTPSY_RS17005	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DTPSY_RS17010	COG0758	DNA mediated transformation
DTPSY_RS17020	COG0242	peptide deformylase activity
DTPSY_RS17030	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DTPSY_RS17045	COG0126	phosphoglycerate kinase activity
DTPSY_RS17055	COG0284	orotidine-5'-phosphate decarboxylase activity
DTPSY_RS17075	COG0840	transmembrane signaling receptor activity
DTPSY_RS17080	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DTPSY_RS17090	COG2814	Major facilitator Superfamily
DTPSY_RS17095	COG0629	single-stranded DNA binding
DTPSY_RS17100	COG1620	l-lactate permease
DTPSY_RS17105	COG0482	sulfurtransferase activity
DTPSY_RS17115	COG1053	succinate dehydrogenase
DTPSY_RS17130	COG2204	response regulator
DTPSY_RS17135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DTPSY_RS17150	COG0439	Biotin carboxylase
DTPSY_RS17155	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DTPSY_RS17205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DTPSY_RS17225	COG1477	protein flavinylation
DTPSY_RS17260	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DTPSY_RS17270	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DTPSY_RS17305	COG1256	bacterial-type flagellum assembly
DTPSY_RS17305	COG4786	Flagellar basal body rod
DTPSY_RS17325	COG1802	Transcriptional regulator
DTPSY_RS17335	COG0559	Belongs to the binding-protein-dependent transport system permease family
DTPSY_RS17340	COG4177	L-phenylalanine transmembrane transporter activity
DTPSY_RS17380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DTPSY_RS17385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DTPSY_RS17390	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DTPSY_RS17400	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DTPSY_RS17415	COG1196	nuclear chromosome segregation
DTPSY_RS17425	COG2267	carboxylic ester hydrolase activity
DTPSY_RS17440	COG0840	transmembrane signaling receptor activity
DTPSY_RS17445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DTPSY_RS17450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DTPSY_RS17455	COG2119	membrane
DTPSY_RS17460	COG0724	RNA recognition motif
DTPSY_RS17465	COG0724	RNA recognition motif
DTPSY_RS17470	COG0300	oxidoreductase activity
DTPSY_RS17480	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DTPSY_RS17495	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DTPSY_RS17510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DTPSY_RS17520	COG2948	multi-organism process
DTPSY_RS17525	COG3504	Conjugal transfer protein
DTPSY_RS17550	COG3451	type IV secretory pathway VirB4
DTPSY_RS17560	COG3838	Conjugal transfer protein Trbc
DTPSY_RS17565	COG4962	Type ii secretion system protein e
DTPSY_RS17585	COG0583	DNA-binding transcription factor activity
DTPSY_RS17590	COG4566	intracellular signal transduction
DTPSY_RS17635	COG4959	Type IV secretory pathway protease TraF
DTPSY_RS17650	COG1192	Involved in chromosome partitioning
DTPSY_RS17675	COG1396	sequence-specific DNA binding
DTPSY_RS17680	COG5489	Protein of unknown function (DUF736)
DTPSY_RS17710	COG2003	Belongs to the UPF0758 family
DTPSY_RS17715	COG4804	nuclease activity
DTPSY_RS17725	COG0747	negative chemotaxis
DTPSY_RS17730	COG0706	membrane insertase activity
DTPSY_RS17735	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DTPSY_RS17740	COG0594	ribonuclease P activity
DTPSY_RS17745	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DTPSY_RS17785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD