locus-tag	class	description
G7045_RS00005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G7045_RS00010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G7045_RS00010	COG2813	Specifically methylates the guanine in position
G7045_RS00025	COG3180	Ammonia monooxygenase
G7045_RS00030	COG2189	Belongs to the N(4) N(6)-methyltransferase family
G7045_RS00045	COG2267	carboxylic ester hydrolase activity
G7045_RS00050	COG0826	peptidase U32
G7045_RS00055	COG0826	peptidase U32
G7045_RS00060	COG3154	lipid carrier protein
G7045_RS00070	COG0163	prenyltransferase activity
G7045_RS00075	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
G7045_RS00080	COG1254	Belongs to the acylphosphatase family
G7045_RS00090	COG1199	ATP-dependent helicase activity
G7045_RS00095	COG2824	Alkylphosphonate utilization operon protein PhnA
G7045_RS00100	COG1199	ATP-dependent helicase activity
G7045_RS00100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G7045_RS00105	COG2258	MOSC domain
G7045_RS00120	COG0625	glutathione transferase activity
G7045_RS00165	COG1862	Preprotein translocase
G7045_RS00170	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G7045_RS00175	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G7045_RS00185	COG0758	DNA mediated transformation
G7045_RS00195	COG0242	peptide deformylase activity
G7045_RS00200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G7045_RS00205	COG0126	phosphoglycerate kinase activity
G7045_RS00210	COG0284	orotidine-5'-phosphate decarboxylase activity
G7045_RS00215	COG0840	transmembrane signaling receptor activity
G7045_RS00225	COG2814	Major facilitator Superfamily
G7045_RS00230	COG0629	single-stranded DNA binding
G7045_RS00235	COG2137	regulation of response to DNA damage stimulus
G7045_RS00240	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G7045_RS00255	COG0642	Histidine kinase
G7045_RS00265	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
G7045_RS00265	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
G7045_RS00290	COG0625	glutathione transferase activity
G7045_RS00295	COG1301	dicarboxylic acid transport
G7045_RS00305	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G7045_RS00310	COG0045	succinate-CoA ligase (ADP-forming) activity
G7045_RS00315	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G7045_RS00325	COG1716	ATPase activity
G7045_RS00335	COG0006	proline dipeptidase activity
G7045_RS00340	COG0469	pyruvate kinase activity
G7045_RS00365	COG0318	PFAM AMP-dependent synthetase and ligase
G7045_RS00370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G7045_RS00420	COG0367	asparagine synthase
G7045_RS00470	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
G7045_RS00480	COG0598	Magnesium transport protein CorA
G7045_RS00490	COG0456	acetyltransferase
G7045_RS00490	COG1214	PFAM Peptidase M22, glycoprotease
G7045_RS00495	COG1214	PFAM Peptidase M22, glycoprotease
G7045_RS00500	COG2027	D-alanyl-D-alanine carboxypeptidase
G7045_RS00520	COG0009	L-threonylcarbamoyladenylate synthase
G7045_RS00525	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G7045_RS00530	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G7045_RS00535	COG3118	belongs to the thioredoxin family
G7045_RS00540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G7045_RS00545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G7045_RS00555	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
G7045_RS00560	COG0735	belongs to the Fur family
G7045_RS00565	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G7045_RS00570	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G7045_RS00585	COG0495	leucyl-tRNA aminoacylation
G7045_RS00600	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G7045_RS00605	COG0569	domain protein
G7045_RS00610	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G7045_RS00620	COG3158	transport of potassium into the cell
G7045_RS00625	COG3135	benzoate transporter
G7045_RS00630	COG0189	ligase activity
G7045_RS00660	COG0789	Transcriptional regulator
G7045_RS00665	COG1960	acyl-CoA dehydrogenase activity
G7045_RS00670	COG0288	reversible hydration of carbon dioxide
G7045_RS00675	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
G7045_RS00680	COG0183	Belongs to the thiolase family
G7045_RS00715	COG3012	SEC-C Motif Domain Protein
G7045_RS00720	COG0747	negative chemotaxis
G7045_RS00725	COG5001	Diguanylate cyclase
G7045_RS00725	COG4251	negative regulation of phosphorylation
G7045_RS00725	COG2203	Gaf domain
G7045_RS00725	COG3706	GGDEF domain
G7045_RS00730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G7045_RS00745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G7045_RS00750	COG1024	Enoyl-CoA hydratase
G7045_RS00795	COG0840	transmembrane signaling receptor activity
G7045_RS00845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G7045_RS00860	COG0792	nuclease activity
G7045_RS00865	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
G7045_RS00870	COG2823	Periplasmic or secreted lipoprotein
G7045_RS00875	COG2084	Dehydrogenase
G7045_RS00885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G7045_RS00925	COG0277	FAD linked oxidase domain protein
G7045_RS00945	COG3850	Histidine kinase
G7045_RS00950	COG2197	response regulator
G7045_RS00970	COG2223	nitrite transmembrane transporter activity
G7045_RS00975	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
G7045_RS00980	COG1140	nitrate reductase beta subunit
G7045_RS00985	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
G7045_RS00990	COG2181	nitrate reductase activity
G7045_RS00995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G7045_RS01020	COG3945	hemerythrin HHE cation binding domain
G7045_RS01040	COG1979	alcohol dehydrogenase
G7045_RS01065	COG0243	molybdopterin cofactor binding
G7045_RS01075	COG1473	amidohydrolase
G7045_RS01110	COG0318	PFAM AMP-dependent synthetase and ligase
G7045_RS01125	COG3186	Phenylalanine-4-hydroxylase
G7045_RS01135	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
G7045_RS01145	COG4535	Mg2 and Co2 transporter CorC
G7045_RS01150	COG0815	Transfers the fatty acyl group on membrane lipoproteins
G7045_RS01155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G7045_RS01170	COG0022	dehydrogenase e1 component
G7045_RS01185	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
G7045_RS01200	COG0752	glycyl-tRNA synthetase alpha subunit
G7045_RS01205	COG0751	glycine-tRNA ligase activity
G7045_RS01215	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
G7045_RS01240	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G7045_RS01260	COG4221	oxidoreductase activity
G7045_RS01290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G7045_RS01295	COG1459	type II secretion system
G7045_RS01300	COG2165	general secretion pathway protein
G7045_RS01310	COG2165	general secretion pathway protein
G7045_RS01340	COG1450	Type ii and iii secretion system protein
G7045_RS01375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G7045_RS01390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G7045_RS01405	COG0343	queuine tRNA-ribosyltransferase activity
G7045_RS01410	COG0589	response to stress
G7045_RS01415	COG2423	ornithine cyclodeaminase activity
G7045_RS01420	COG2010	Cytochrome c
G7045_RS01440	COG2076	Multidrug Resistance protein
G7045_RS01450	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G7045_RS01455	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G7045_RS01460	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
G7045_RS01465	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G7045_RS01470	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G7045_RS01475	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G7045_RS01485	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G7045_RS01490	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G7045_RS01495	COG0316	Belongs to the HesB IscA family
G7045_RS01500	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
G7045_RS01505	COG0739	heme binding
G7045_RS01510	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G7045_RS01515	COG2703	oxygen carrier activity
G7045_RS01520	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G7045_RS01530	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G7045_RS01535	COG0625	glutathione transferase activity
G7045_RS01540	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G7045_RS01545	COG0741	lytic transglycosylase activity
G7045_RS01555	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G7045_RS01565	COG0166	Belongs to the GPI family
G7045_RS01570	COG0459	protein refolding
G7045_RS01575	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G7045_RS01580	COG1051	belongs to the nudix hydrolase family
G7045_RS01580	COG1056	cytidyltransferase-related domain
G7045_RS01585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G7045_RS01595	COG1560	Kdo2-lipid A biosynthetic process
G7045_RS01600	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G7045_RS01610	COG1333	cytochrome c biogenesis protein
G7045_RS01615	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G7045_RS01630	COG1965	Belongs to the frataxin family
G7045_RS01670	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G7045_RS01675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G7045_RS01680	COG0232	Belongs to the dGTPase family. Type 2 subfamily
G7045_RS01690	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
G7045_RS01695	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G7045_RS01700	COG1765	OsmC-like protein
G7045_RS01715	COG1473	amidohydrolase
G7045_RS01740	COG0037	tRNA processing
G7045_RS01760	COG1522	sequence-specific DNA binding
G7045_RS01775	COG0653	protein targeting
G7045_RS01780	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G7045_RS01790	COG0494	nUDIX hydrolase
G7045_RS01795	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
G7045_RS01800	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
G7045_RS01805	COG0237	dephospho-CoA kinase activity
G7045_RS01810	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
G7045_RS01825	COG1396	sequence-specific DNA binding
G7045_RS01845	COG0142	geranyltranstransferase activity
G7045_RS01850	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G7045_RS01855	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G7045_RS01860	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G7045_RS01865	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G7045_RS01870	COG0494	nUDIX hydrolase
G7045_RS01875	COG0442	prolyl-tRNA aminoacylation
G7045_RS01885	COG1253	flavin adenine dinucleotide binding
G7045_RS01890	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G7045_RS01900	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G7045_RS01905	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G7045_RS01915	COG0584	glycerophosphoryl diester phosphodiesterase
G7045_RS01920	COG3842	ATPase activity
G7045_RS01925	COG0395	ABC-type sugar transport system, permease component
G7045_RS01930	COG1175	transmembrane transport
G7045_RS01935	COG1653	transport
G7045_RS01940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G7045_RS01975	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G7045_RS01995	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G7045_RS02005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G7045_RS02010	COG0302	gtp cyclohydrolase
G7045_RS02025	COG1280	lysine exporter protein (LysE YggA)
G7045_RS02030	COG0747	negative chemotaxis
G7045_RS02045	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G7045_RS02050	COG0193	aminoacyl-tRNA hydrolase activity
G7045_RS02055	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G7045_RS02060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G7045_RS02070	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G7045_RS02075	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
G7045_RS02085	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G7045_RS02095	COG1194	a g-specific adenine glycosylase
G7045_RS02100	COG1660	Displays ATPase and GTPase activities
G7045_RS02105	COG0497	DNA recombination
G7045_RS02110	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G7045_RS02115	COG1420	regulation of RNA biosynthetic process
G7045_RS02235	COG1396	sequence-specific DNA binding
G7045_RS02240	COG3550	peptidyl-serine autophosphorylation
G7045_RS02255	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G7045_RS02260	COG1758	RNA polymerase activity
G7045_RS02265	COG0194	GDP metabolic process
G7045_RS02270	COG1561	YicC-like family, N-terminal region
G7045_RS02290	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G7045_RS02295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G7045_RS02320	COG3622	Belongs to the hyi family
G7045_RS02325	COG0840	transmembrane signaling receptor activity
G7045_RS02330	COG5001	Diguanylate cyclase
G7045_RS02330	COG3300	MHYT domain
G7045_RS02335	COG0745	RESPONSE REGULATOR receiver
G7045_RS02345	COG0653	protein targeting
G7045_RS02360	COG0840	transmembrane signaling receptor activity
G7045_RS02370	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
G7045_RS02375	COG1137	ATPase activity
G7045_RS02385	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G7045_RS02395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G7045_RS02405	COG0018	arginyl-trna synthetase
G7045_RS02415	COG0840	transmembrane signaling receptor activity
G7045_RS02440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G7045_RS02445	COG0134	indole-3-glycerol-phosphate synthase activity
G7045_RS02450	COG5001	Diguanylate cyclase
G7045_RS02450	COG3300	MHYT domain
G7045_RS02455	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G7045_RS02460	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G7045_RS02465	COG3162	membrane
G7045_RS02470	COG0477	Major facilitator Superfamily
G7045_RS02475	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G7045_RS02480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G7045_RS02485	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
G7045_RS02495	COG0732	type I restriction modification DNA specificity domain
G7045_RS02500	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
G7045_RS02505	COG0156	8-amino-7-oxononanoate synthase activity
G7045_RS02510	COG2267	carboxylic ester hydrolase activity
G7045_RS02515	COG2226	methyltransferase
G7045_RS02535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G7045_RS02560	COG0612	Peptidase, M16
G7045_RS02565	COG0612	Peptidase, M16
G7045_RS02570	COG0742	ribosomal rna small subunit methyltransferase
G7045_RS02575	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G7045_RS02585	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G7045_RS02590	COG0793	Belongs to the peptidase S41A family
G7045_RS02595	COG0588	phosphoglycerate mutase activity
G7045_RS02600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G7045_RS02610	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
G7045_RS02615	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G7045_RS02655	COG0281	malic enzyme
G7045_RS02655	COG0280	phosphate acetyltransferase
G7045_RS02660	COG2116	formate transmembrane transporter activity
G7045_RS02675	COG5001	Diguanylate cyclase
G7045_RS02675	COG3300	MHYT domain
G7045_RS02685	COG2223	nitrite transmembrane transporter activity
G7045_RS02690	COG0243	molybdopterin cofactor binding
G7045_RS02700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G7045_RS02705	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G7045_RS02710	COG0159	tryptophan synthase activity
G7045_RS02715	COG0133	tryptophan synthase activity
G7045_RS02720	COG0135	phosphoribosylanthranilate isomerase activity
G7045_RS02725	COG0101	tRNA pseudouridine synthase activity
G7045_RS02740	COG0473	3-isopropylmalate dehydrogenase activity
G7045_RS02745	COG0066	3-isopropylmalate dehydratase activity
G7045_RS02755	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G7045_RS02760	COG0583	DNA-binding transcription factor activity
G7045_RS02765	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G7045_RS02770	COG0484	heat shock protein binding
G7045_RS02775	COG0443	Heat shock 70 kDa protein
G7045_RS02780	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G7045_RS02785	COG0360	Binds together with S18 to 16S ribosomal RNA
G7045_RS02790	COG2965	DNA replication, synthesis of RNA primer
G7045_RS02795	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G7045_RS02800	COG0359	binds to the 23S rRNA
G7045_RS02805	COG0305	Participates in initiation and elongation during chromosome replication
G7045_RS02810	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
G7045_RS02815	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G7045_RS02825	COG0436	Aminotransferase
G7045_RS02835	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G7045_RS02840	COG1763	Mo-molybdopterin cofactor biosynthetic process
G7045_RS02845	COG0303	'Molybdopterin
G7045_RS02865	COG0314	molybdopterin synthase activity
G7045_RS02875	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
G7045_RS02885	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
G7045_RS02900	COG2205	protein histidine kinase activity
G7045_RS02905	COG0745	RESPONSE REGULATOR receiver
G7045_RS02910	COG0542	response to heat
G7045_RS02920	COG1012	belongs to the aldehyde dehydrogenase family
G7045_RS02930	COG2813	Specifically methylates the guanine in position
G7045_RS02940	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
G7045_RS02950	COG0822	iron-sulfur transferase activity
G7045_RS02955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G7045_RS02965	COG0396	ATPase activity
G7045_RS02970	COG0719	Fe-S assembly protein
G7045_RS02975	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G7045_RS02980	COG1185	polyribonucleotide nucleotidyltransferase activity
G7045_RS02985	COG3321	synthase
G7045_RS02985	COG1028	Short-chain dehydrogenase reductase Sdr
G7045_RS02985	COG0604	alcohol dehydrogenase
G7045_RS02990	COG0149	triose-phosphate isomerase activity
G7045_RS03005	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G7045_RS03010	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G7045_RS03015	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G7045_RS03020	COG0649	NAD binding
G7045_RS03035	COG1034	ATP synthesis coupled electron transport
G7045_RS03040	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G7045_RS03045	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G7045_RS03055	COG0713	ATP synthesis coupled electron transport
G7045_RS03070	COG1007	ATP synthesis coupled electron transport
G7045_RS03115	COG4774	siderophore transport
G7045_RS03155	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G7045_RS03160	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G7045_RS03165	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G7045_RS03170	COG0586	Pfam SNARE associated Golgi protein
G7045_RS03175	COG0860	N-Acetylmuramoyl-L-alanine amidase
G7045_RS03180	COG0802	atpase or kinase
G7045_RS03185	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G7045_RS03190	COG3447	MASE1 domain protein
G7045_RS03190	COG5001	Diguanylate cyclase
G7045_RS03190	COG5002	protein histidine kinase activity
G7045_RS03200	COG4974	Belongs to the 'phage' integrase family
G7045_RS03205	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
G7045_RS03210	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
G7045_RS03215	COG2833	Protein of unknown function (DUF455)
G7045_RS03225	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G7045_RS03250	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
G7045_RS03255	COG0148	phosphopyruvate hydratase activity
G7045_RS03260	COG2877	3-deoxy-8-phosphooctulonate synthase activity
G7045_RS03265	COG0504	CTP synthase activity
G7045_RS03270	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G7045_RS03275	COG0756	dUTP diphosphatase activity
G7045_RS03330	COG1573	uracil-dna glycosylase
G7045_RS03335	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G7045_RS03365	COG1392	Phosphate transport regulator
G7045_RS03370	COG0306	phosphate transporter
G7045_RS03375	COG0084	hydrolase, TatD family'
G7045_RS03380	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
G7045_RS03385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G7045_RS03415	COG0697	spore germination
G7045_RS03425	COG1283	sodium-dependent phosphate transmembrane transporter activity
G7045_RS03430	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G7045_RS03435	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G7045_RS03440	COG0196	riboflavin kinase activity
G7045_RS03445	COG3781	membrane
G7045_RS03450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G7045_RS03455	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G7045_RS03460	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G7045_RS03460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G7045_RS03465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G7045_RS03470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G7045_RS03475	COG0492	ferredoxin-NADP+ reductase activity
G7045_RS03480	COG1674	ftsk spoiiie
G7045_RS03485	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
G7045_RS03490	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G7045_RS03490	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G7045_RS03515	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G7045_RS03530	COG3437	response regulator, receiver
G7045_RS03545	COG1045	serine acetyltransferase
G7045_RS03550	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
G7045_RS03555	COG1959	2 iron, 2 sulfur cluster binding
G7045_RS03560	COG0583	DNA-binding transcription factor activity
G7045_RS03570	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
G7045_RS03585	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G7045_RS03600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7045_RS03615	COG0789	Transcriptional regulator
G7045_RS03630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G7045_RS03640	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G7045_RS03650	COG0318	PFAM AMP-dependent synthetase and ligase
G7045_RS03655	COG0733	neurotransmitter:sodium symporter activity
G7045_RS03660	COG3540	Alkaline phosphatase
G7045_RS03670	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
G7045_RS03675	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G7045_RS03685	COG0564	pseudouridine synthase activity
G7045_RS03690	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G7045_RS03695	COG1187	pseudouridine synthase activity
G7045_RS03700	COG0105	UTP biosynthetic process
G7045_RS03705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G7045_RS03720	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
G7045_RS03725	COG0124	histidyl-tRNA synthetase
G7045_RS03740	COG1160	GTP binding
G7045_RS03745	COG1923	regulation of RNA biosynthetic process
G7045_RS03750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G7045_RS03755	COG0330	HflC and HflK could
G7045_RS03760	COG0330	HflC and HflK could
G7045_RS03770	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
G7045_RS03775	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G7045_RS03780	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
G7045_RS03840	COG0174	glutamine synthetase
G7045_RS03855	COG2204	response regulator
G7045_RS03860	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G7045_RS03865	COG0708	Exodeoxyribonuclease III
G7045_RS03880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G7045_RS03890	COG1309	transcriptional regulator
G7045_RS03895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7045_RS03900	COG1131	(ABC) transporter
G7045_RS03905	COG0842	Transport permease protein
G7045_RS03910	COG0842	Transport permease protein
G7045_RS03925	COG0842	Transport permease protein
G7045_RS03925	COG1129	ABC transporter
G7045_RS03955	COG1074	ATP-dependent DNA helicase activity
G7045_RS03970	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
G7045_RS04000	COG0840	transmembrane signaling receptor activity
G7045_RS04020	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G7045_RS04025	COG0277	FAD linked oxidase domain protein
G7045_RS04035	COG1295	ribonuclease BN
G7045_RS04050	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G7045_RS04060	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G7045_RS04065	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G7045_RS04070	COG0741	lytic transglycosylase activity
G7045_RS04095	COG3344	reverse transcriptase
G7045_RS04100	COG0557	exoribonuclease II activity
G7045_RS04105	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G7045_RS04105	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G7045_RS04110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7045_RS04120	COG0052	Belongs to the universal ribosomal protein uS2 family
G7045_RS04125	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G7045_RS04130	COG0528	UMP kinase activity
G7045_RS04135	COG0233	cytoplasmic translational termination
G7045_RS04140	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G7045_RS04145	COG0575	Belongs to the CDS family
G7045_RS04150	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G7045_RS04155	COG0750	zinc metalloprotease
G7045_RS04170	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G7045_RS04175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G7045_RS04180	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G7045_RS04185	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G7045_RS04190	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G7045_RS04195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G7045_RS04200	COG0505	Belongs to the CarA family
G7045_RS04205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G7045_RS04210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G7045_RS04220	COG1534	Rna-binding protein
G7045_RS04225	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
G7045_RS04230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G7045_RS04240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G7045_RS04285	COG2183	response to ionizing radiation
G7045_RS04300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G7045_RS04310	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G7045_RS04335	COG3634	alkyl hydroperoxide reductase activity
G7045_RS04375	COG0672	)-iron permease
G7045_RS04400	COG0560	Phosphoserine phosphatase
G7045_RS04415	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G7045_RS04420	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G7045_RS04420	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G7045_RS04425	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G7045_RS04435	COG2205	protein histidine kinase activity
G7045_RS04455	COG1960	acyl-CoA dehydrogenase activity
G7045_RS04460	COG2070	2-Nitropropane dioxygenase
G7045_RS04470	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G7045_RS04495	COG0215	cysteine-tRNA ligase activity
G7045_RS04505	COG0825	malonyl-CoA metabolic process
G7045_RS04510	COG0840	transmembrane signaling receptor activity
G7045_RS04515	COG0037	tRNA processing
G7045_RS04535	COG1518	maintenance of DNA repeat elements
G7045_RS04575	COG1203	CRISPR-associated helicase, Cas3
G7045_RS04585	COG1067	ATP-dependent peptidase activity
G7045_RS04590	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G7045_RS04600	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
G7045_RS04610	COG1760	l-serine dehydratase
G7045_RS04625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G7045_RS04635	COG0544	peptidyl-prolyl cis-trans isomerase activity
G7045_RS04640	COG0740	serine-type endopeptidase activity
G7045_RS04645	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G7045_RS04680	COG1451	nucleotide metabolic process
G7045_RS04685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G7045_RS04690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G7045_RS04705	COG1785	Belongs to the alkaline phosphatase family
G7045_RS04720	COG0129	dihydroxy-acid dehydratase activity
G7045_RS04735	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G7045_RS04745	COG0589	response to stress
G7045_RS04750	COG2217	Heavy metal translocating P-type atpase
G7045_RS04760	COG3278	Belongs to the heme-copper respiratory oxidase family
G7045_RS04780	COG0348	domain, Protein
G7045_RS04790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G7045_RS04795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G7045_RS04805	COG3437	response regulator, receiver
G7045_RS04815	COG0730	response to heat
G7045_RS04830	COG4206	TonB-dependent receptor
G7045_RS04835	COG1797	cobyrinic acid a,c-diamide synthase activity
G7045_RS04845	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
G7045_RS04850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G7045_RS04855	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
G7045_RS04870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G7045_RS04910	COG0778	Nitroreductase
G7045_RS04915	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
G7045_RS04955	COG0354	folic acid binding
G7045_RS04960	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G7045_RS04965	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G7045_RS04980	COG0084	hydrolase, TatD family'
G7045_RS04990	COG1132	(ABC) transporter
G7045_RS04995	COG0823	Involved in the tonB-independent uptake of proteins
G7045_RS05010	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G7045_RS05025	COG0567	Dehydrogenase, E1 component
G7045_RS05030	COG0508	dehydrogenase complex catalyzes the overall conversion of
G7045_RS05035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G7045_RS05040	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G7045_RS05050	COG0631	protein serine/threonine phosphatase activity
G7045_RS05055	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G7045_RS05070	COG0433	COG0433 Predicted ATPase
G7045_RS05075	COG0217	transcriptional regulatory protein
G7045_RS05080	COG0151	Belongs to the GarS family
G7045_RS05085	COG0408	coproporphyrinogen oxidase activity
G7045_RS05090	COG0799	negative regulation of ribosome biogenesis
G7045_RS05095	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G7045_RS05100	COG0424	maF-like protein
G7045_RS05115	COG0714	Associated with various cellular activities
G7045_RS05125	COG2010	Cytochrome c
G7045_RS05135	COG1845	cytochrome c oxidase, subunit III
G7045_RS05165	COG3391	amine dehydrogenase activity
G7045_RS05170	COG2010	Cytochrome c
G7045_RS05180	COG1648	precorrin-2 dehydrogenase activity
G7045_RS05180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G7045_RS05185	COG1530	ribonuclease E activity
G7045_RS05200	COG1393	Belongs to the ArsC family
G7045_RS05205	COG0285	dihydrofolate synthase activity
G7045_RS05230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G7045_RS05270	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G7045_RS05295	COG4206	TonB-dependent receptor
G7045_RS05310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G7045_RS05315	COG1120	ATPase activity
G7045_RS05320	COG0500	methyltransferase
G7045_RS05335	COG4149	molybdate abc transporter
G7045_RS05365	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G7045_RS05370	COG0835	chemotaxis
G7045_RS05375	COG0840	transmembrane signaling receptor activity
G7045_RS05390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G7045_RS05395	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G7045_RS05400	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G7045_RS05405	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G7045_RS05410	COG1388	LysM domain
G7045_RS05410	COG0741	lytic transglycosylase activity
G7045_RS05415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G7045_RS05420	COG2226	methyltransferase
G7045_RS05425	COG0328	RNA-DNA hybrid ribonuclease activity
G7045_RS05440	COG0746	molybdenum cofactor guanylyltransferase activity
G7045_RS05445	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G7045_RS05475	COG1982	Orn Lys Arg decarboxylase major
G7045_RS05480	COG1793	dna ligase
G7045_RS05485	COG2841	Protein conserved in bacteria
G7045_RS05495	COG1840	ABC-type Fe3 transport system, periplasmic component
G7045_RS05510	COG2832	Protein of unknown function (DUF454)
G7045_RS05525	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
G7045_RS05535	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G7045_RS05535	COG0047	phosphoribosylformylglycinamidine synthase activity
G7045_RS05540	COG2354	Protein conserved in bacteria
G7045_RS05545	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G7045_RS05560	COG0798	PFAM Bile acid sodium symporter
G7045_RS05565	COG1902	pentaerythritol trinitrate reductase activity
G7045_RS05570	COG3047	cAMP biosynthetic process
G7045_RS05575	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G7045_RS05580	COG0583	DNA-binding transcription factor activity
G7045_RS05590	COG0826	peptidase U32
G7045_RS05605	COG1619	proteins homologs of microcin C7 resistance protein MccF
G7045_RS05610	COG3621	Patatin-like phospholipase
G7045_RS05615	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G7045_RS05615	COG0506	proline dehydrogenase activity
G7045_RS05615	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G7045_RS05625	COG1960	acyl-CoA dehydrogenase activity
G7045_RS05635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G7045_RS05650	COG2022	thiamine diphosphate biosynthetic process
G7045_RS05665	COG0351	phosphomethylpyrimidine kinase
G7045_RS05670	COG0492	ferredoxin-NADP+ reductase activity
G7045_RS05675	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G7045_RS05690	COG0175	sulfate reduction
G7045_RS05705	COG0730	response to heat
G7045_RS05710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7045_RS05710	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
G7045_RS05715	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
G7045_RS05725	COG0688	phosphatidylethanolamine metabolic process
G7045_RS05730	COG0517	IMP dehydrogenase activity
G7045_RS05735	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G7045_RS05750	COG0589	response to stress
G7045_RS05775	COG0167	dihydroorotate dehydrogenase activity
G7045_RS05780	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
G7045_RS05795	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G7045_RS05800	COG4566	intracellular signal transduction
G7045_RS05810	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
G7045_RS05815	COG0508	dehydrogenase complex catalyzes the overall conversion of
G7045_RS05820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G7045_RS05870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G7045_RS05875	COG0697	spore germination
G7045_RS05880	COG3189	MarR family transcriptional regulator
G7045_RS05895	COG0791	NLP P60 protein
G7045_RS05905	COG0205	6-phosphofructokinase activity
G7045_RS05910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G7045_RS05925	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G7045_RS05930	COG2755	lipolytic protein G-D-S-L family
G7045_RS05930	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G7045_RS05985	COG1960	acyl-CoA dehydrogenase activity
G7045_RS05995	COG0583	DNA-binding transcription factor activity
G7045_RS06000	COG1113	amino acid transport
G7045_RS06015	COG2852	Protein conserved in bacteria
G7045_RS06030	COG1396	sequence-specific DNA binding
G7045_RS06030	COG3800	Transcriptional regulator
G7045_RS06040	COG1196	nuclear chromosome segregation
G7045_RS06050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G7045_RS06090	COG3243	poly(R)-hydroxyalkanoic acid synthase
G7045_RS06095	COG0183	Belongs to the thiolase family
G7045_RS06100	COG1028	Short-chain dehydrogenase reductase Sdr
G7045_RS06105	COG0488	(ABC) transporter
G7045_RS06110	COG2890	protein-(glutamine-N5) methyltransferase activity
G7045_RS06115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G7045_RS06125	COG2171	N-acyltransferase activity
G7045_RS06130	COG0436	Aminotransferase
G7045_RS06135	COG0840	transmembrane signaling receptor activity
G7045_RS06140	COG2878	Part of a membrane complex involved in electron transport
G7045_RS06175	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G7045_RS06180	COG1061	Type III restriction enzyme res subunit
G7045_RS06185	COG1002	Type II restriction enzyme, methylase subunits
G7045_RS06195	COG4691	Plasmid stability protein
G7045_RS06210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G7045_RS06295	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G7045_RS06300	COG2011	ABC-type metal ion transport system permease component
G7045_RS06305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G7045_RS06310	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G7045_RS06315	COG0583	DNA-binding transcription factor activity
G7045_RS06320	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
G7045_RS06325	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
G7045_RS06330	COG4208	sulfate ABC transporter
G7045_RS06340	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G7045_RS06360	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
G7045_RS06365	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
G7045_RS06365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G7045_RS06370	COG2755	lipolytic protein G-D-S-L family
G7045_RS06370	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G7045_RS06375	COG1643	Atp-dependent helicase
G7045_RS06395	COG1022	Amp-dependent synthetase and ligase
G7045_RS06400	COG1802	Transcriptional regulator
G7045_RS06405	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G7045_RS06405	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G7045_RS06420	COG1703	isobutyryl-CoA mutase activity
G7045_RS06425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G7045_RS06430	COG4770	biotin carboxylase activity
G7045_RS06445	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G7045_RS06485	COG0640	Transcriptional regulator
G7045_RS06490	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
G7045_RS06495	COG1943	Transposase
G7045_RS06500	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
G7045_RS06505	COG0732	type I restriction modification DNA specificity domain
G7045_RS06510	COG4628	conserved protein (DUF2132)
G7045_RS06515	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
G7045_RS06520	COG0346	lactoylglutathione lyase activity
G7045_RS06530	COG0583	DNA-binding transcription factor activity
G7045_RS06535	COG3038	cytochrome b561
G7045_RS06540	COG2353	YceI-like domain
G7045_RS06545	COG2353	YceI-like domain
G7045_RS06550	COG0259	pyridoxamine-phosphate oxidase activity
G7045_RS06565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G7045_RS06585	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G7045_RS06620	COG0133	tryptophan synthase activity
G7045_RS06645	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G7045_RS06650	COG1570	exodeoxyribonuclease VII activity
G7045_RS06655	COG0811	peptide transport
G7045_RS06660	COG0848	biopolymer transport protein
G7045_RS06665	COG1663	tetraacyldisaccharide 4'-kinase activity
G7045_RS06670	COG2835	tetraacyldisaccharide 4'-kinase activity
G7045_RS06675	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
G7045_RS06680	COG0563	adenylate kinase activity
G7045_RS06690	COG1794	racemase activity, acting on amino acids and derivatives
G7045_RS06695	COG0252	asparaginase activity
G7045_RS06700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G7045_RS06705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G7045_RS06720	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G7045_RS06740	COG0583	DNA-binding transcription factor activity
G7045_RS06745	COG0436	Aminotransferase
G7045_RS06755	COG0564	pseudouridine synthase activity
G7045_RS06760	COG1028	Short-chain dehydrogenase reductase Sdr
G7045_RS06765	COG0183	Belongs to the thiolase family
G7045_RS06780	COG0789	Transcriptional regulator
G7045_RS06785	COG0776	regulation of translation
G7045_RS06790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G7045_RS06790	COG0072	phenylalanine-tRNA ligase activity
G7045_RS06795	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G7045_RS06800	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G7045_RS06805	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G7045_RS06810	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G7045_RS06815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G7045_RS06830	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G7045_RS06840	COG4774	siderophore transport
G7045_RS06845	COG3128	pkhd-type hydroxylase
G7045_RS06880	COG1253	flavin adenine dinucleotide binding
G7045_RS06910	COG0443	Heat shock 70 kDa protein
G7045_RS06925	COG0822	iron-sulfur transferase activity
G7045_RS06930	COG1104	cysteine desulfurase activity
G7045_RS06940	COG0556	nucleotide-excision repair
G7045_RS06950	COG0542	response to heat
G7045_RS06955	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G7045_RS06980	COG1028	Short-chain dehydrogenase reductase Sdr
G7045_RS07005	COG1136	(ABC) transporter
G7045_RS07015	COG3033	Beta-eliminating lyase
G7045_RS07025	COG4120	Belongs to the binding-protein-dependent transport system permease family
G7045_RS07030	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
G7045_RS07035	COG0833	amino acid
G7045_RS07045	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G7045_RS07050	COG0509	glycine decarboxylation via glycine cleavage system
G7045_RS07055	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G7045_RS07055	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G7045_RS07220	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G7045_RS07225	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G7045_RS07230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G7045_RS07235	COG0195	Participates in both transcription termination and antitermination
G7045_RS07240	COG0779	Required for maturation of 30S ribosomal subunits
G7045_RS07250	COG4172	Belongs to the ABC transporter superfamily
G7045_RS07255	COG4239	(ABC) transporter, permease
G7045_RS07270	COG4174	ABC transporter (Permease)
G7045_RS07280	COG4166	transmembrane transport
G7045_RS07295	COG2719	SpoVR family
G7045_RS07300	COG2718	Belongs to the UPF0229 family
G7045_RS07305	COG2766	serine protein kinase
G7045_RS07340	COG1739	Uncharacterized protein family UPF0029
G7045_RS07350	COG0501	Belongs to the peptidase M48B family
G7045_RS07370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G7045_RS07375	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
G7045_RS07380	COG4181	ATPase activity
G7045_RS07390	COG0626	cystathionine gamma-synthase activity
G7045_RS07420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G7045_RS07425	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G7045_RS07430	COG3706	GGDEF domain
G7045_RS07435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G7045_RS07445	COG5002	protein histidine kinase activity
G7045_RS07445	COG5001	Diguanylate cyclase
G7045_RS07460	COG0564	pseudouridine synthase activity
G7045_RS07465	COG2925	Exonuclease
G7045_RS07470	COG2951	lytic endotransglycosylase activity
G7045_RS07480	COG0446	pyridine nucleotide-disulphide oxidoreductase
G7045_RS07480	COG1902	pentaerythritol trinitrate reductase activity
G7045_RS07495	COG0254	rRNA binding
G7045_RS07505	COG0534	Mate efflux family protein
G7045_RS07520	COG0704	Plays a role in the regulation of phosphate uptake
G7045_RS07525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G7045_RS07530	COG0581	inorganic phosphate transmembrane transporter activity
G7045_RS07535	COG0573	inorganic phosphate transmembrane transporter activity
G7045_RS07540	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G7045_RS07590	COG0183	Belongs to the thiolase family
G7045_RS07595	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7045_RS07595	COG1024	Enoyl-CoA hydratase
G7045_RS07600	COG1129	ABC transporter
G7045_RS07605	COG0411	ABC transporter
G7045_RS07615	COG0559	Belongs to the binding-protein-dependent transport system permease family
G7045_RS07620	COG0318	PFAM AMP-dependent synthetase and ligase
G7045_RS07630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G7045_RS07635	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G7045_RS07640	COG2917	probably involved in intracellular septation
G7045_RS07650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G7045_RS07655	COG1611	Belongs to the LOG family
G7045_RS07660	COG1322	Protein conserved in bacteria
G7045_RS07675	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
G7045_RS07680	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
G7045_RS07685	COG1414	Transcriptional regulator
G7045_RS07690	COG0789	Transcriptional regulator
G7045_RS07710	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
G7045_RS07720	COG3191	aminopeptidase activity
G7045_RS07730	COG0488	(ABC) transporter
G7045_RS07735	COG0513	Belongs to the DEAD box helicase family
G7045_RS07745	COG0322	excinuclease ABC activity
G7045_RS07755	COG0776	regulation of translation
G7045_RS07765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G7045_RS07775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G7045_RS07795	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G7045_RS07800	COG0670	Belongs to the BI1 family
G7045_RS07810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G7045_RS07815	COG4716	Myosin-crossreactive antigen
G7045_RS07820	COG3123	guanosine phosphorylase activity
G7045_RS07825	COG0137	argininosuccinate synthase activity
G7045_RS07830	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G7045_RS07835	COG0583	DNA-binding transcription factor activity
G7045_RS07850	COG1666	GTP binding
G7045_RS07860	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G7045_RS07875	COG0308	aminopeptidase N
G7045_RS07880	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
G7045_RS07910	COG3719	Belongs to the RNase T2 family
G7045_RS07920	COG2948	multi-organism process
G7045_RS07935	COG3846	protein secretion by the type IV secretion system
G7045_RS07955	COG4959	Type IV secretory pathway protease TraF
G7045_RS07970	COG1192	Involved in chromosome partitioning
G7045_RS08005	COG5489	Protein of unknown function (DUF736)
G7045_RS08095	COG0582	viral genome integration into host DNA
G7045_RS08100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G7045_RS08100	COG0519	Catalyzes the synthesis of GMP from XMP
G7045_RS08115	COG2914	Belongs to the UPF0125 (RnfH) family
G7045_RS08120	COG2867	negative regulation of translational initiation
G7045_RS08125	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G7045_RS08130	COG1024	Enoyl-CoA hydratase
G7045_RS08145	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G7045_RS08150	COG0077	Prephenate dehydratase
G7045_RS08150	COG1605	Chorismate mutase
G7045_RS08155	COG0287	Prephenate dehydrogenase
G7045_RS08160	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G7045_RS08170	COG0776	regulation of translation
G7045_RS08180	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
G7045_RS08190	COG2111	Na H antiporter
G7045_RS08190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G7045_RS08195	COG1006	Multisubunit Na H antiporter MnhC subunit
G7045_RS08200	COG0651	ATP synthesis coupled electron transport
G7045_RS08210	COG2212	antiporter activity
G7045_RS08225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G7045_RS08235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G7045_RS08240	COG1183	phosphatidylcholine synthase activity
G7045_RS08245	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G7045_RS08255	COG0028	Belongs to the TPP enzyme family
G7045_RS08260	COG1595	DNA-templated transcription, initiation
G7045_RS08280	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
G7045_RS08290	COG0347	Belongs to the P(II) protein family
G7045_RS08360	COG0318	PFAM AMP-dependent synthetase and ligase
G7045_RS08400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G7045_RS08405	COG4771	TonB-dependent receptor
G7045_RS08420	COG0776	regulation of translation
G7045_RS08440	COG2948	multi-organism process
G7045_RS08455	COG3846	protein secretion by the type IV secretion system
G7045_RS08470	COG3451	type IV secretory pathway VirB4
G7045_RS08485	COG4962	Type ii secretion system protein e
G7045_RS08510	COG0583	DNA-binding transcription factor activity
G7045_RS08560	COG1396	sequence-specific DNA binding
G7045_RS08570	COG5489	Protein of unknown function (DUF736)
G7045_RS08605	COG4974	Belongs to the 'phage' integrase family
G7045_RS08610	COG0517	IMP dehydrogenase activity
G7045_RS08615	COG0251	oxidation-reduction process
G7045_RS08675	COG1475	DNA binding
G7045_RS08795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G7045_RS08805	COG1028	Short-chain dehydrogenase reductase Sdr
G7045_RS08815	COG0745	RESPONSE REGULATOR receiver
G7045_RS08820	COG0668	transmembrane transport
G7045_RS08835	COG0714	Associated with various cellular activities
G7045_RS08850	COG2951	lytic endotransglycosylase activity
G7045_RS08855	COG0683	leucine binding
G7045_RS08860	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G7045_RS08865	COG0517	IMP dehydrogenase activity
G7045_RS08865	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
G7045_RS08870	COG0840	transmembrane signaling receptor activity
G7045_RS08875	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G7045_RS08880	COG2081	HI0933 family
G7045_RS08885	COG0828	Belongs to the bacterial ribosomal protein bS21 family
G7045_RS08900	COG0312	modulator of DNA gyrase
G7045_RS08905	COG3028	Belongs to the UPF0307 family
G7045_RS08910	COG0521	Mo-molybdopterin cofactor biosynthetic process
G7045_RS08920	COG3530	Putative quorum-sensing-regulated virulence factor
G7045_RS08925	COG2900	Belongs to the SlyX family
G7045_RS08930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G7045_RS08935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G7045_RS08945	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
G7045_RS08950	COG1492	cobalamin metabolic process
G7045_RS08960	COG0564	pseudouridine synthase activity
G7045_RS08965	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
G7045_RS08975	COG1289	transmembrane transporter activity
G7045_RS08980	COG2918	glutathione biosynthetic process
G7045_RS08985	COG1028	Short-chain dehydrogenase reductase Sdr
G7045_RS09000	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G7045_RS09005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G7045_RS09010	COG0436	Aminotransferase
G7045_RS09015	COG0824	Thioesterase
G7045_RS09050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G7045_RS09070	COG0039	L-malate dehydrogenase activity
G7045_RS09075	COG2188	Transcriptional regulator
G7045_RS09080	COG2009	succinate dehydrogenase
G7045_RS09090	COG1053	succinate dehydrogenase
G7045_RS09095	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G7045_RS09100	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
G7045_RS09105	COG0372	Belongs to the citrate synthase family
G7045_RS09110	COG2194	sulfuric ester hydrolase activity
G7045_RS09115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G7045_RS09135	COG0840	transmembrane signaling receptor activity
G7045_RS09155	COG0187	DNA topoisomerase II activity
G7045_RS09170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G7045_RS09175	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
G7045_RS09190	COG2850	peptidyl-arginine hydroxylation
G7045_RS09210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G7045_RS09260	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G7045_RS09265	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G7045_RS09275	COG1722	exodeoxyribonuclease VII activity
G7045_RS09340	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
G7045_RS09345	COG0181	hydroxymethylbilane synthase activity
G7045_RS09355	COG2959	enzyme of heme biosynthesis
G7045_RS09365	COG0114	fumarate hydratase activity
G7045_RS09385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7045_RS09405	COG2010	Cytochrome c
G7045_RS09425	COG0525	valine-tRNA ligase activity
G7045_RS09430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G7045_RS09440	COG2255	four-way junction helicase activity
G7045_RS09460	COG0631	protein serine/threonine phosphatase activity
G7045_RS09465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G7045_RS09490	COG3268	Saccharopine dehydrogenase
G7045_RS09495	COG1960	acyl-CoA dehydrogenase activity
G7045_RS09505	COG0425	Belongs to the sulfur carrier protein TusA family
G7045_RS09525	COG1960	acyl-CoA dehydrogenase activity
G7045_RS09550	COG3181	Tripartite tricarboxylate transporter family receptor
G7045_RS09565	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G7045_RS09570	COG0463	Glycosyl transferase, family 2
G7045_RS09575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G7045_RS09580	COG0617	tRNA 3'-terminal CCA addition
G7045_RS09590	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G7045_RS09595	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G7045_RS09605	COG0589	response to stress
G7045_RS09615	COG0728	peptidoglycan biosynthetic process
G7045_RS09620	COG0268	Binds directly to 16S ribosomal RNA
G7045_RS09630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G7045_RS09635	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G7045_RS09640	COG0727	PFAM Uncharacterised protein family (UPF0153)
G7045_RS09645	COG1946	Acyl-CoA thioesterase
G7045_RS09650	COG0727	PFAM Uncharacterised protein family (UPF0153)
G7045_RS09655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G7045_RS09660	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G7045_RS09670	COG1253	flavin adenine dinucleotide binding
G7045_RS09675	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G7045_RS09680	COG1477	protein flavinylation
G7045_RS09685	COG3245	cytochrome
G7045_RS09695	COG4263	nitrous-oxide reductase activity
G7045_RS09700	COG3901	Regulator of nitric oxide reductase transcription
G7045_RS09700	COG0348	domain, Protein
G7045_RS09730	COG0513	Belongs to the DEAD box helicase family
G7045_RS09735	COG0717	Belongs to the dCTP deaminase family
G7045_RS09740	COG2366	antibiotic biosynthetic process
G7045_RS09770	COG5002	protein histidine kinase activity
G7045_RS09770	COG3447	MASE1 domain protein
G7045_RS09770	COG5001	Diguanylate cyclase
G7045_RS09785	COG0762	integral membrane protein
G7045_RS09795	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G7045_RS09810	COG1472	Belongs to the glycosyl hydrolase 3 family
G7045_RS09815	COG0736	holo-[acyl-carrier-protein] synthase activity
G7045_RS09820	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
G7045_RS09825	COG1381	Involved in DNA repair and RecF pathway recombination
G7045_RS09830	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G7045_RS09835	COG0571	ribonuclease III activity
G7045_RS09845	COG0681	Belongs to the peptidase S26 family
G7045_RS09850	COG0481	GTPase activity
G7045_RS09855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G7045_RS09875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G7045_RS09880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G7045_RS09885	COG1028	Short-chain dehydrogenase reductase Sdr
G7045_RS09890	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G7045_RS09895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G7045_RS09900	COG0416	fatty acid biosynthetic process
G7045_RS09905	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G7045_RS09910	COG1399	metal-binding, possibly nucleic acid-binding protein
G7045_RS09915	COG0424	maF-like protein
G7045_RS09920	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
G7045_RS09935	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G7045_RS09935	COG0616	signal peptide processing
G7045_RS09955	COG1530	ribonuclease E activity
G7045_RS09960	COG3022	response to hydroperoxide
G7045_RS09970	COG1297	OPT oligopeptide transporter protein
G7045_RS09975	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G7045_RS09975	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G7045_RS09980	COG0840	transmembrane signaling receptor activity
G7045_RS09985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G7045_RS09990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G7045_RS10005	COG0625	glutathione transferase activity
G7045_RS10020	COG0165	Argininosuccinate lyase
G7045_RS10025	COG0745	RESPONSE REGULATOR receiver
G7045_RS10025	COG2972	Histidine kinase
G7045_RS10065	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G7045_RS10080	COG0210	DNA helicase
G7045_RS10085	COG0516	GMP reductase activity
G7045_RS10095	COG2084	Dehydrogenase
G7045_RS10105	COG2814	Major facilitator Superfamily
G7045_RS10110	COG3300	MHYT domain
G7045_RS10110	COG5001	Diguanylate cyclase
G7045_RS10115	COG0513	Belongs to the DEAD box helicase family
G7045_RS10125	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
G7045_RS10130	COG0501	Belongs to the peptidase M48B family
G7045_RS10135	COG2154	pterin-4-alpha-carbinolamine dehydratase
G7045_RS10140	COG1162	GTPase activity
G7045_RS10145	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
G7045_RS10150	COG0494	nUDIX hydrolase
G7045_RS10155	COG0335	large ribosomal subunit rRNA binding
G7045_RS10160	COG0336	Belongs to the RNA methyltransferase TrmD family
G7045_RS10165	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G7045_RS10170	COG0228	four-way junction DNA binding
G7045_RS10175	COG1136	(ABC) transporter
G7045_RS10180	COG4591	ABC-type transport system involved in lipoprotein release permease component
G7045_RS10190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G7045_RS10195	COG2755	lipolytic protein G-D-S-L family
G7045_RS10195	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G7045_RS10200	COG0840	transmembrane signaling receptor activity
G7045_RS10210	COG0840	transmembrane signaling receptor activity
G7045_RS10215	COG0613	PHP domain protein
G7045_RS10220	COG0009	L-threonylcarbamoyladenylate synthase
G7045_RS10225	COG1994	Peptidase M50
G7045_RS10230	COG0180	Tryptophanyl-tRNA synthetase
G7045_RS10245	COG0582	viral genome integration into host DNA
G7045_RS10255	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
G7045_RS10515	COG4695	Portal protein
G7045_RS10550	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G7045_RS10560	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G7045_RS10565	COG1047	Peptidyl-prolyl cis-trans
G7045_RS10570	COG2003	Belongs to the UPF0758 family
G7045_RS10580	COG1193	negative regulation of DNA recombination
G7045_RS10610	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G7045_RS10620	COG0437	4 iron, 4 sulfur cluster binding
G7045_RS10625	COG2864	formate dehydrogenase
G7045_RS10635	COG1921	L-seryl-tRNASec selenium transferase activity
G7045_RS10645	COG3276	selenocysteine insertion sequence binding
G7045_RS10660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G7045_RS10680	COG0302	gtp cyclohydrolase
G7045_RS10685	COG0709	Synthesizes selenophosphate from selenide and ATP
G7045_RS10690	COG0489	protein tyrosine kinase activity
G7045_RS10705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G7045_RS10705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G7045_RS10715	COG0446	pyridine nucleotide-disulphide oxidoreductase
G7045_RS10770	COG4566	intracellular signal transduction
G7045_RS10805	COG4221	oxidoreductase activity
G7045_RS10820	COG0028	Belongs to the TPP enzyme family
G7045_RS10840	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
G7045_RS10850	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
G7045_RS10860	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
G7045_RS10890	COG1999	signal sequence binding
G7045_RS10895	COG2226	methyltransferase
G7045_RS10905	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G7045_RS10920	COG1280	lysine exporter protein (LysE YggA)
G7045_RS10925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G7045_RS10925	COG0475	glutathione-regulated potassium exporter activity
G7045_RS10930	COG2860	membrane
G7045_RS10940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G7045_RS10970	COG1393	Belongs to the ArsC family
G7045_RS10975	COG1178	ABC-type Fe3 transport system permease component
G7045_RS10980	COG3842	ATPase activity
G7045_RS10995	COG0540	Belongs to the ATCase OTCase family
G7045_RS11000	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
G7045_RS11005	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G7045_RS11010	COG1678	Uncharacterized ACR, COG1678
G7045_RS11015	COG0643	Histidine kinase
G7045_RS11015	COG0784	Response regulator, receiver
G7045_RS11015	COG2198	Histidine kinase
G7045_RS11020	COG0840	transmembrane signaling receptor activity
G7045_RS11025	COG0835	chemotaxis
G7045_RS11045	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G7045_RS11050	COG0138	bifunctional purine biosynthesis protein purh
G7045_RS11055	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
G7045_RS11065	COG1238	metal cluster binding
G7045_RS11075	COG0012	GTP binding
G7045_RS11080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G7045_RS11095	COG1024	Enoyl-CoA hydratase
G7045_RS11105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G7045_RS11130	COG4969	Belongs to the N-Me-Phe pilin family
G7045_RS11155	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G7045_RS11160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G7045_RS11185	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G7045_RS11185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G7045_RS11190	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G7045_RS11200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G7045_RS11210	COG2264	protein methyltransferase activity
G7045_RS11215	COG0439	Biotin carboxylase
G7045_RS11220	COG0511	ligase activity, forming carbon-carbon bonds
G7045_RS11225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G7045_RS11235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G7045_RS11245	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G7045_RS11255	COG0312	modulator of DNA gyrase
G7045_RS11260	COG0772	Belongs to the SEDS family
G7045_RS11270	COG0557	exoribonuclease II activity
G7045_RS11280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G7045_RS11285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G7045_RS11290	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
G7045_RS11295	COG0840	transmembrane signaling receptor activity
G7045_RS11305	COG0840	transmembrane signaling receptor activity
G7045_RS11310	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G7045_RS11320	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G7045_RS11325	COG0724	RNA recognition motif
G7045_RS11330	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
G7045_RS11335	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G7045_RS11345	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G7045_RS11350	COG1181	Belongs to the D-alanine--D-alanine ligase family
G7045_RS11355	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G7045_RS11360	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G7045_RS11365	COG0772	Belongs to the SEDS family
G7045_RS11370	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G7045_RS11375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G7045_RS11380	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G7045_RS11385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G7045_RS11400	COG0275	rRNA processing
G7045_RS11405	COG2001	Belongs to the MraZ family
G7045_RS11410	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
G7045_RS11415	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
G7045_RS11430	COG0523	cobalamin synthesis protein
G7045_RS11440	COG2205	protein histidine kinase activity
G7045_RS11445	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
G7045_RS11455	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G7045_RS11495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G7045_RS11505	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
G7045_RS11510	COG0501	Belongs to the peptidase M48B family
G7045_RS11525	COG0418	dihydroorotase activity
G7045_RS11530	COG1126	abc transporter atp-binding protein
G7045_RS11535	COG0765	amino acid transport
G7045_RS11540	COG0765	amino acid transport
G7045_RS11545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G7045_RS11555	COG0583	DNA-binding transcription factor activity
G7045_RS11560	COG2203	Gaf domain
G7045_RS11560	COG3706	GGDEF domain
G7045_RS11560	COG4251	negative regulation of phosphorylation
G7045_RS11560	COG5001	Diguanylate cyclase
G7045_RS11565	COG5265	(ABC) transporter
G7045_RS11570	COG2050	protein possibly involved in aromatic compounds catabolism
G7045_RS11575	COG1024	Enoyl-CoA hydratase
G7045_RS11585	COG0183	Belongs to the thiolase family
G7045_RS11590	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7045_RS11590	COG1024	Enoyl-CoA hydratase
G7045_RS11600	COG1960	acyl-CoA dehydrogenase activity
G7045_RS11610	COG1309	transcriptional regulator
G7045_RS11620	COG0318	PFAM AMP-dependent synthetase and ligase
G7045_RS11620	COG0204	Acyl-transferase
G7045_RS11640	COG0617	tRNA 3'-terminal CCA addition
G7045_RS11645	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
G7045_RS11650	COG2847	Copper chaperone PCu(A)C
G7045_RS11665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G7045_RS11670	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G7045_RS11680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G7045_RS11690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G7045_RS11710	COG4774	siderophore transport
G7045_RS11715	COG2382	esterase
G7045_RS11725	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7045_RS11730	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G7045_RS11745	COG2969	positive regulation of protein catabolic process
G7045_RS11750	COG0625	glutathione transferase activity
G7045_RS11755	COG2857	Cytochrome c1
G7045_RS11760	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G7045_RS11765	COG0723	plastoquinol--plastocyanin reductase activity
G7045_RS11770	COG1970	mechanosensitive ion channel activity
G7045_RS11775	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G7045_RS11780	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G7045_RS11790	COG0805	protein transport
G7045_RS11795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G7045_RS11800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G7045_RS11815	COG0140	phosphoribosyl-ATP diphosphatase activity
G7045_RS11820	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G7045_RS11825	COG0107	imidazoleglycerol-phosphate synthase activity
G7045_RS11830	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G7045_RS11860	COG0438	transferase activity, transferring glycosyl groups
G7045_RS11880	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G7045_RS11890	COG0131	Imidazoleglycerol-phosphate dehydratase
G7045_RS11895	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G7045_RS11905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G7045_RS11915	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G7045_RS11920	COG4804	nuclease activity
G7045_RS11925	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G7045_RS11930	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G7045_RS11935	COG5007	Belongs to the BolA IbaG family
G7045_RS11940	COG0842	Transport permease protein
G7045_RS11945	COG1131	(ABC) transporter
G7045_RS11950	COG3447	MASE1 domain protein
G7045_RS11950	COG5001	Diguanylate cyclase
G7045_RS11950	COG5002	protein histidine kinase activity
G7045_RS11970	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G7045_RS11975	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G7045_RS11980	COG1127	ABC transporter
G7045_RS11990	COG0765	amino acid transport
G7045_RS12005	COG0070	glutamate synthase
G7045_RS12005	COG0067	glutamate synthase
G7045_RS12005	COG0069	glutamate synthase activity
G7045_RS12025	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G7045_RS12030	COG0280	phosphate acetyltransferase
G7045_RS12035	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G7045_RS12045	COG3243	poly(R)-hydroxyalkanoic acid synthase
G7045_RS12050	COG0840	transmembrane signaling receptor activity
G7045_RS12055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G7045_RS12055	COG0045	succinate-CoA ligase (ADP-forming) activity
G7045_RS12055	COG1042	CoA-binding domain protein
G7045_RS12070	COG0443	Heat shock 70 kDa protein
G7045_RS12075	COG1126	abc transporter atp-binding protein
G7045_RS12080	COG0765	amino acid transport
G7045_RS12085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G7045_RS12100	COG0671	phosphoesterase, PA-phosphatase related
G7045_RS12105	COG0443	Heat shock 70 kDa protein
G7045_RS12110	COG2255	four-way junction helicase activity
G7045_RS12125	COG0632	four-way junction helicase activity
G7045_RS12130	COG1702	phosphate starvation-inducible protein PhoH
G7045_RS12135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G7045_RS12140	COG0730	response to heat
G7045_RS12150	COG0203	ribosomal protein L17
G7045_RS12155	COG0202	RNA polymerase activity
G7045_RS12160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G7045_RS12165	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G7045_RS12170	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G7045_RS12175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G7045_RS12180	COG0201	protein transport
G7045_RS12185	COG0200	Binds to the 23S rRNA
G7045_RS12190	COG1841	ribosomal large subunit assembly
G7045_RS12195	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G7045_RS12200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G7045_RS12205	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G7045_RS12210	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G7045_RS12215	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G7045_RS12220	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G7045_RS12225	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G7045_RS12230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G7045_RS12235	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G7045_RS12250	COG0395	ABC-type sugar transport system, permease component
G7045_RS12265	COG3842	ATPase activity
G7045_RS12275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G7045_RS12285	COG4969	Belongs to the N-Me-Phe pilin family
G7045_RS12325	COG3846	protein secretion by the type IV secretion system
G7045_RS12340	COG3451	type IV secretory pathway VirB4
G7045_RS12350	COG3838	Conjugal transfer protein Trbc
G7045_RS12355	COG4962	Type ii secretion system protein e
G7045_RS12375	COG0583	DNA-binding transcription factor activity
G7045_RS12415	COG0501	Belongs to the peptidase M48B family
G7045_RS12445	COG1192	Involved in chromosome partitioning
G7045_RS12485	COG5489	Protein of unknown function (DUF736)
G7045_RS12490	COG1695	Transcriptional regulator
G7045_RS12535	COG2814	Major facilitator Superfamily
G7045_RS12540	COG1937	Protein conserved in bacteria
G7045_RS12550	COG4804	nuclease activity
G7045_RS12565	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G7045_RS12570	COG0783	Belongs to the Dps family
G7045_RS12590	COG1490	D-aminoacyl-tRNA deacylase activity
G7045_RS12595	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
G7045_RS12605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G7045_RS12690	COG1132	(ABC) transporter
G7045_RS12695	COG0189	ligase activity
G7045_RS12695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G7045_RS12700	COG1181	Belongs to the D-alanine--D-alanine ligase family
G7045_RS12700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G7045_RS12705	COG3045	CreA protein
G7045_RS12750	COG2201	protein-glutamate methylesterase activity
G7045_RS12755	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
G7045_RS12760	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G7045_RS12765	COG0835	chemotaxis
G7045_RS12770	COG0643	Histidine kinase
G7045_RS12770	COG2198	Histidine kinase
G7045_RS12775	COG2201	protein-glutamate methylesterase activity
G7045_RS12790	COG2197	response regulator
G7045_RS12800	COG1987	bacterial-type flagellum assembly
G7045_RS12815	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G7045_RS12825	COG1580	Controls the rotational direction of flagella during chemotaxis
G7045_RS12855	COG1766	The M ring may be actively involved in energy transduction
G7045_RS12860	COG1677	Flagellar hook-basal body complex protein FliE
G7045_RS12925	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G7045_RS12935	COG1360	Flagellar Motor Protein
G7045_RS12940	COG0745	RESPONSE REGULATOR receiver
G7045_RS12945	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
G7045_RS12955	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G7045_RS12990	COG1815	bacterial-type flagellum-dependent cell motility
G7045_RS12995	COG1558	bacterial-type flagellum-dependent cell motility
G7045_RS13000	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
G7045_RS13020	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
G7045_RS13025	COG1706	bacterial-type flagellum-dependent cell motility
G7045_RS13030	COG3951	Flagellar rod assembly protein muramidase FlgJ
G7045_RS13030	COG1705	Flagellar rod assembly protein muramidase FlgJ
G7045_RS13035	COG1256	bacterial-type flagellum assembly
G7045_RS13035	COG4786	Flagellar basal body rod
G7045_RS13085	COG0210	DNA helicase
G7045_RS13100	COG0577	efflux transmembrane transporter activity
G7045_RS13100	COG1136	(ABC) transporter
G7045_RS13125	COG0546	phosphoglycolate phosphatase activity
G7045_RS13130	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G7045_RS13135	COG2967	ApaG domain
G7045_RS13150	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
G7045_RS13175	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G7045_RS13180	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G7045_RS13190	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
G7045_RS13200	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G7045_RS13205	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G7045_RS13220	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G7045_RS13240	COG1942	4-Oxalocrotonate Tautomerase
G7045_RS13245	COG0121	glutamine amidotransferase
G7045_RS13250	COG1304	FMN binding
G7045_RS13255	COG0326	Molecular chaperone. Has ATPase activity
G7045_RS13265	COG2119	membrane
G7045_RS13285	COG2204	response regulator
G7045_RS13290	COG5000	phosphorelay sensor kinase activity
G7045_RS13300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G7045_RS13300	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G7045_RS13310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G7045_RS13315	COG0085	RNA polymerase activity
G7045_RS13320	COG0222	ribosome binding
G7045_RS13325	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G7045_RS13330	COG0081	regulation of translation
G7045_RS13335	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G7045_RS13355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G7045_RS13385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7045_RS13400	COG3245	cytochrome
G7045_RS13410	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G7045_RS13415	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G7045_RS13420	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G7045_RS13425	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G7045_RS13430	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G7045_RS13435	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G7045_RS13445	COG0356	it plays a direct role in the translocation of protons across the membrane
G7045_RS13455	COG2921	Belongs to the UPF0250 family
G7045_RS13460	COG0321	lipoyl(octanoyl) transferase activity
G7045_RS13465	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G7045_RS13480	COG1127	ABC transporter
G7045_RS13485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G7045_RS13490	COG0730	response to heat
G7045_RS13495	COG0010	Belongs to the arginase family
G7045_RS13500	COG0768	penicillin binding
G7045_RS13510	COG1792	Involved in formation and maintenance of cell shape
G7045_RS13515	COG1077	Cell shape determining protein MreB Mrl
G7045_RS13520	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G7045_RS13525	COG0154	amidase activity
G7045_RS13530	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G7045_RS13540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G7045_RS13545	COG0708	Exodeoxyribonuclease III
G7045_RS13555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G7045_RS13565	COG0386	Belongs to the glutathione peroxidase family
G7045_RS13575	COG0840	transmembrane signaling receptor activity
G7045_RS13590	COG0247	lactate metabolic process
G7045_RS13600	COG0277	FAD linked oxidase domain protein
G7045_RS13605	COG2203	Gaf domain
G7045_RS13605	COG3706	GGDEF domain
G7045_RS13605	COG4251	negative regulation of phosphorylation
G7045_RS13605	COG5001	Diguanylate cyclase
G7045_RS13610	COG0004	ammonium transporteR
G7045_RS13625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G7045_RS13630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G7045_RS13640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G7045_RS13645	COG0456	acetyltransferase
G7045_RS13650	COG0678	peroxiredoxin activity
G7045_RS13655	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G7045_RS13660	COG0255	Belongs to the universal ribosomal protein uL29 family
G7045_RS13665	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G7045_RS13670	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G7045_RS13675	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G7045_RS13680	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G7045_RS13685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G7045_RS13690	COG0089	rRNA binding
G7045_RS13695	COG0088	Forms part of the polypeptide exit tunnel
G7045_RS13700	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G7045_RS13705	COG0051	transcription antitermination factor activity, RNA binding
G7045_RS13710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G7045_RS13715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G7045_RS13720	COG0049	tRNA binding
G7045_RS13725	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G7045_RS13730	COG1686	Belongs to the peptidase S11 family
G7045_RS13735	COG2945	thiolester hydrolase activity
G7045_RS13765	COG0598	Magnesium transport protein CorA
G7045_RS13780	COG0277	FAD linked oxidase domain protein
G7045_RS13785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G7045_RS13790	COG1070	Carbohydrate kinase
G7045_RS13795	COG0477	Major facilitator Superfamily
G7045_RS13800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G7045_RS13830	COG0463	Glycosyl transferase, family 2
G7045_RS13840	COG0477	Major facilitator Superfamily
G7045_RS13845	COG2205	protein histidine kinase activity
G7045_RS13850	COG0745	RESPONSE REGULATOR receiver
G7045_RS13855	COG2211	Major facilitator Superfamily
G7045_RS13870	COG1410	methionine synthase
G7045_RS13870	COG0646	methionine synthase
G7045_RS13880	COG0753	catalase activity
G7045_RS13885	COG2204	response regulator
G7045_RS13900	COG4771	TonB-dependent receptor
G7045_RS13925	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G7045_RS13955	COG3550	peptidyl-serine autophosphorylation
G7045_RS13985	COG3604	Transcriptional regulator
G7045_RS13990	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G7045_RS13995	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
G7045_RS14005	COG2096	Adenosyltransferase
G7045_RS14010	COG2050	protein possibly involved in aromatic compounds catabolism
G7045_RS14025	COG2233	PERMEase
G7045_RS14035	COG1183	phosphatidylcholine synthase activity
G7045_RS14040	COG0850	regulation of cytokinetic process
G7045_RS14050	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
G7045_RS14055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G7045_RS14070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7045_RS14125	COG1475	DNA binding
G7045_RS14150	COG1192	Involved in chromosome partitioning
G7045_RS14155	COG0357	Ribosomal RNA small subunit methyltransferase G
G7045_RS14160	COG0445	tRNA wobble uridine modification
G7045_RS14180	COG0625	glutathione transferase activity
G7045_RS14185	COG0840	transmembrane signaling receptor activity
G7045_RS14200	COG0789	Transcriptional regulator
G7045_RS14220	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
G7045_RS14230	COG0700	Nucleoside recognition
G7045_RS14235	COG2974	May be involved in recombination
G7045_RS14245	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G7045_RS14250	COG0791	NLP P60 protein
G7045_RS14255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G7045_RS14265	COG0861	Integral membrane protein TerC family
G7045_RS14270	COG1950	PFAM Membrane protein of
G7045_RS14275	COG4783	chaperone-mediated protein folding
G7045_RS14280	COG0315	cyclic pyranopterin monophosphate synthase activity
G7045_RS14290	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G7045_RS14295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G7045_RS14300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G7045_RS14310	COG1047	Peptidyl-prolyl cis-trans
G7045_RS14330	COG0482	sulfurtransferase activity
G7045_RS14365	COG2205	protein histidine kinase activity
G7045_RS14370	COG0745	RESPONSE REGULATOR receiver
G7045_RS14400	COG0840	transmembrane signaling receptor activity
G7045_RS14405	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
G7045_RS14435	COG0281	malic enzyme
G7045_RS14435	COG0280	phosphate acetyltransferase
G7045_RS14450	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G7045_RS14455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G7045_RS14460	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G7045_RS14470	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G7045_RS14515	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G7045_RS14520	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G7045_RS14530	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G7045_RS14535	COG0706	membrane insertase activity
G7045_RS14540	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G7045_RS14560	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G7045_RS14580	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
G7045_RS14590	COG0300	oxidoreductase activity
G7045_RS14595	COG0724	RNA recognition motif
G7045_RS14600	COG0724	RNA recognition motif