locus-tag	class	description
C380_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C380_RS00025	COG0318	PFAM AMP-dependent synthetase and ligase
C380_RS00065	COG1254	Belongs to the acylphosphatase family
C380_RS00105	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C380_RS00110	COG2199	diguanylate cyclase activity
C380_RS00110	COG2203	Gaf domain
C380_RS00145	COG2824	Alkylphosphonate utilization operon protein PhnA
C380_RS00165	COG2176	DNA-directed DNA polymerase activity
C380_RS00190	COG4941	Belongs to the sigma-70 factor family
C380_RS00210	COG3795	YCII-related domain
C380_RS00215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C380_RS00220	COG0791	NLP P60 protein
C380_RS00230	COG3384	dioxygenase
C380_RS00240	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C380_RS00255	COG0583	DNA-binding transcription factor activity
C380_RS00260	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C380_RS00285	COG2974	May be involved in recombination
C380_RS00290	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C380_RS00295	COG1741	Belongs to the pirin family
C380_RS00305	COG1024	Enoyl-CoA hydratase
C380_RS00310	COG1022	Amp-dependent synthetase and ligase
C380_RS00350	COG3550	peptidyl-serine autophosphorylation
C380_RS00380	COG0789	Transcriptional regulator
C380_RS00390	COG2217	Heavy metal translocating P-type atpase
C380_RS00395	COG0840	transmembrane signaling receptor activity
C380_RS00405	COG1902	pentaerythritol trinitrate reductase activity
C380_RS00415	COG0625	glutathione transferase activity
C380_RS00425	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C380_RS00430	COG1595	DNA-templated transcription, initiation
C380_RS00450	COG0357	Ribosomal RNA small subunit methyltransferase G
C380_RS00460	COG1192	Involved in chromosome partitioning
C380_RS00480	COG1475	DNA binding
C380_RS00565	COG1201	RNA secondary structure unwinding
C380_RS00570	COG1793	dna ligase
C380_RS00575	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C380_RS00575	COG1793	dna ligase
C380_RS00585	COG4166	transmembrane transport
C380_RS00590	COG1742	UPF0060 membrane protein
C380_RS00595	COG0640	Transcriptional regulator
C380_RS00620	COG0277	FAD linked oxidase domain protein
C380_RS00660	COG0765	amino acid transport
C380_RS00665	COG0765	amino acid transport
C380_RS00670	COG1126	abc transporter atp-binding protein
C380_RS00685	COG2096	Adenosyltransferase
C380_RS00690	COG2050	protein possibly involved in aromatic compounds catabolism
C380_RS00695	COG0683	leucine binding
C380_RS00710	COG2233	PERMEase
C380_RS00740	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C380_RS00745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C380_RS00755	COG0318	PFAM AMP-dependent synthetase and ligase
C380_RS00760	COG1183	phosphatidylcholine synthase activity
C380_RS00765	COG0384	phenazine biosynthesis protein PhzF
C380_RS00770	COG0583	DNA-binding transcription factor activity
C380_RS00785	COG0850	regulation of cytokinetic process
C380_RS00795	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C380_RS00800	COG1289	transmembrane transporter activity
C380_RS00810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C380_RS00815	COG0596	Alpha beta hydrolase
C380_RS00820	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C380_RS00830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C380_RS00845	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C380_RS00850	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C380_RS00875	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C380_RS00880	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C380_RS00885	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C380_RS00890	COG3604	Transcriptional regulator
C380_RS00895	COG3256	nitric oxide reductase
C380_RS00920	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C380_RS00925	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C380_RS00930	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C380_RS00935	COG0277	FAD linked oxidase domain protein
C380_RS00950	COG0583	DNA-binding transcription factor activity
C380_RS00960	COG0037	tRNA processing
C380_RS00965	COG0826	peptidase U32
C380_RS00985	COG2211	Major facilitator Superfamily
C380_RS00990	COG0318	PFAM AMP-dependent synthetase and ligase
C380_RS00995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C380_RS01010	COG2326	polyphosphate kinase activity
C380_RS01040	COG0646	methionine synthase
C380_RS01040	COG1410	methionine synthase
C380_RS01045	COG0251	oxidation-reduction process
C380_RS01060	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C380_RS01085	COG1295	ribonuclease BN
C380_RS01100	COG1309	transcriptional regulator
C380_RS01145	COG0411	ABC transporter
C380_RS01160	COG2080	2 iron, 2 sulfur cluster binding
C380_RS01165	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C380_RS01165	COG2010	Cytochrome c
C380_RS01190	COG1522	sequence-specific DNA binding
C380_RS01220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C380_RS01230	COG1960	acyl-CoA dehydrogenase activity
C380_RS01250	COG1024	Enoyl-CoA hydratase
C380_RS01285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C380_RS01315	COG1538	Outer membrane efflux protein
C380_RS01320	COG0606	chelatase, subunit chli
C380_RS01335	COG0004	ammonium transporteR
C380_RS01340	COG0277	FAD linked oxidase domain protein
C380_RS01350	COG0247	lactate metabolic process
C380_RS01355	COG1278	Cold shock
C380_RS01360	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C380_RS01380	COG3279	Response regulator of the LytR AlgR family
C380_RS01395	COG0386	Belongs to the glutathione peroxidase family
C380_RS01405	COG0477	Major facilitator Superfamily
C380_RS01410	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C380_RS01440	COG0747	negative chemotaxis
C380_RS01445	COG0625	glutathione transferase activity
C380_RS01450	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C380_RS01480	COG0463	Glycosyl transferase, family 2
C380_RS01485	COG3307	-O-antigen
C380_RS01505	COG0477	Major facilitator Superfamily
C380_RS01515	COG0745	RESPONSE REGULATOR receiver
C380_RS01520	COG2211	Major facilitator Superfamily
C380_RS01525	COG4783	chaperone-mediated protein folding
C380_RS01530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C380_RS01555	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C380_RS01560	COG0708	Exodeoxyribonuclease III
C380_RS01565	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C380_RS01575	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C380_RS01580	COG0154	amidase activity
C380_RS01585	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C380_RS01590	COG1077	Cell shape determining protein MreB Mrl
C380_RS01595	COG1792	Involved in formation and maintenance of cell shape
C380_RS01600	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C380_RS01605	COG0768	penicillin binding
C380_RS01620	COG0765	amino acid transport
C380_RS01625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C380_RS01635	COG0004	ammonium transporteR
C380_RS01655	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C380_RS01660	COG1127	ABC transporter
C380_RS01690	COG3237	CsbD-like
C380_RS01715	COG4452	Inner membrane protein CreD
C380_RS01725	COG2205	protein histidine kinase activity
C380_RS01730	COG0745	RESPONSE REGULATOR receiver
C380_RS01735	COG2095	MarC family integral membrane protein
C380_RS01740	COG1028	Short-chain dehydrogenase reductase Sdr
C380_RS01745	COG0412	Dienelactone hydrolase
C380_RS01755	COG0598	Magnesium transport protein CorA
C380_RS01765	COG1981	membrane
C380_RS01780	COG2945	thiolester hydrolase activity
C380_RS01785	COG1686	Belongs to the peptidase S11 family
C380_RS01790	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C380_RS01795	COG0049	tRNA binding
C380_RS01800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C380_RS01805	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C380_RS01810	COG0051	transcription antitermination factor activity, RNA binding
C380_RS01815	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C380_RS01820	COG0088	Forms part of the polypeptide exit tunnel
C380_RS01825	COG0089	rRNA binding
C380_RS01830	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C380_RS01835	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C380_RS01840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C380_RS01845	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C380_RS01850	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C380_RS01855	COG0255	Belongs to the universal ribosomal protein uL29 family
C380_RS01860	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C380_RS01865	COG0678	peroxiredoxin activity
C380_RS01885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C380_RS01905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C380_RS01910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C380_RS01925	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C380_RS01930	COG0321	lipoyl(octanoyl) transferase activity
C380_RS01935	COG2921	Belongs to the UPF0250 family
C380_RS01945	COG0356	it plays a direct role in the translocation of protons across the membrane
C380_RS01955	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C380_RS01960	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C380_RS01965	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C380_RS01970	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C380_RS01975	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C380_RS01980	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C380_RS02025	COG3245	cytochrome
C380_RS02035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C380_RS02040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C380_RS02070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C380_RS02080	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C380_RS02090	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C380_RS02095	COG0081	regulation of translation
C380_RS02100	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C380_RS02105	COG0222	ribosome binding
C380_RS02110	COG0085	RNA polymerase activity
C380_RS02115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C380_RS02125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C380_RS02125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C380_RS02135	COG5000	phosphorelay sensor kinase activity
C380_RS02140	COG2204	response regulator
C380_RS02160	COG0582	viral genome integration into host DNA
C380_RS02175	COG0443	Heat shock 70 kDa protein
C380_RS02185	COG0792	nuclease activity
C380_RS02190	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C380_RS02195	COG2823	Periplasmic or secreted lipoprotein
C380_RS02200	COG2084	Dehydrogenase
C380_RS02210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C380_RS02220	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C380_RS02240	COG0318	PFAM AMP-dependent synthetase and ligase
C380_RS02245	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C380_RS02250	COG1280	lysine exporter protein (LysE YggA)
C380_RS02265	COG2733	membrane
C380_RS02270	COG1346	cytolysis
C380_RS02275	COG1380	Effector of murein hydrolase LrgA
C380_RS02280	COG0277	FAD linked oxidase domain protein
C380_RS02285	COG0583	DNA-binding transcription factor activity
C380_RS02305	COG3850	Histidine kinase
C380_RS02310	COG2197	response regulator
C380_RS02320	COG2223	nitrite transmembrane transporter activity
C380_RS02325	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C380_RS02330	COG1140	nitrate reductase beta subunit
C380_RS02335	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C380_RS02340	COG2181	nitrate reductase activity
C380_RS02345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C380_RS02350	COG0288	reversible hydration of carbon dioxide
C380_RS02370	COG3945	hemerythrin HHE cation binding domain
C380_RS02415	COG0583	DNA-binding transcription factor activity
C380_RS02420	COG1979	alcohol dehydrogenase
C380_RS02435	COG0243	molybdopterin cofactor binding
C380_RS02450	COG1473	amidohydrolase
C380_RS02480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C380_RS02485	COG2423	ornithine cyclodeaminase activity
C380_RS02505	COG2818	Glycosylase
C380_RS02520	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C380_RS02525	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C380_RS02530	COG1609	Transcriptional regulator
C380_RS02535	COG3624	Phosphonate C-P lyase system protein PhnG
C380_RS02540	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
C380_RS02545	COG3626	phosphonate metabolism
C380_RS02550	COG3627	carbon phosphorus lyase activity
C380_RS02560	COG4107	phosphonate C-P lyase system protein PhnK
C380_RS02565	COG4778	phosphonate C-P lyase system protein PhnL
C380_RS02570	COG3454	Phosphonate metabolism
C380_RS02575	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C380_RS02580	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C380_RS02585	COG3639	organic phosphonate transmembrane transporter activity
C380_RS02610	COG0697	spore germination
C380_RS02615	COG0251	oxidation-reduction process
C380_RS02625	COG1960	acyl-CoA dehydrogenase activity
C380_RS02630	COG1024	Enoyl-CoA hydratase
C380_RS02645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C380_RS02695	COG3267	Type II secretory pathway component ExeA
C380_RS02695	COG3409	Peptidoglycan-binding domain 1 protein
C380_RS02710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C380_RS02715	COG0840	transmembrane signaling receptor activity
C380_RS02735	COG1187	pseudouridine synthase activity
C380_RS02750	COG0326	Molecular chaperone. Has ATPase activity
C380_RS02760	COG0745	RESPONSE REGULATOR receiver
C380_RS02765	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C380_RS02775	COG0515	serine threonine protein kinase
C380_RS02775	COG2815	serine threonine protein kinase
C380_RS02790	COG1764	response to oxidative stress
C380_RS02795	COG1846	Transcriptional regulator
C380_RS02800	COG1024	Enoyl-CoA hydratase
C380_RS02805	COG1250	3-hydroxyacyl-CoA dehydrogenase
C380_RS02830	COG0842	Transport permease protein
C380_RS02840	COG2197	response regulator
C380_RS02845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C380_RS02850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C380_RS02855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C380_RS02855	COG1116	anion transmembrane transporter activity
C380_RS02860	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C380_RS02880	COG0446	pyridine nucleotide-disulphide oxidoreductase
C380_RS02920	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C380_RS02930	COG1131	(ABC) transporter
C380_RS02935	COG3186	Phenylalanine-4-hydroxylase
C380_RS02950	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C380_RS02955	COG1522	sequence-specific DNA binding
C380_RS02970	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C380_RS02975	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C380_RS02995	COG0752	glycyl-tRNA synthetase alpha subunit
C380_RS03000	COG0751	glycine-tRNA ligase activity
C380_RS03005	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C380_RS03025	COG1652	LysM domain
C380_RS03030	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C380_RS03050	COG4221	oxidoreductase activity
C380_RS03095	COG0438	transferase activity, transferring glycosyl groups
C380_RS03105	COG0463	Glycosyl transferase, family 2
C380_RS03115	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C380_RS03130	COG0438	transferase activity, transferring glycosyl groups
C380_RS03140	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C380_RS03175	COG0438	transferase activity, transferring glycosyl groups
C380_RS03220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C380_RS03225	COG0745	RESPONSE REGULATOR receiver
C380_RS03235	COG1309	transcriptional regulator
C380_RS03245	COG1960	acyl-CoA dehydrogenase activity
C380_RS03255	COG1250	3-hydroxyacyl-CoA dehydrogenase
C380_RS03255	COG1024	Enoyl-CoA hydratase
C380_RS03265	COG0183	Belongs to the thiolase family
C380_RS03280	COG1024	Enoyl-CoA hydratase
C380_RS03290	COG1028	Short-chain dehydrogenase reductase Sdr
C380_RS03295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C380_RS03300	COG4335	DNA alkylation repair
C380_RS03305	COG1960	acyl-CoA dehydrogenase activity
C380_RS03310	COG1024	Enoyl-CoA hydratase
C380_RS03320	COG1960	acyl-CoA dehydrogenase activity
C380_RS03325	COG3246	L-lysine catabolic process to acetate
C380_RS03335	COG1024	Enoyl-CoA hydratase
C380_RS03335	COG1250	3-hydroxyacyl-CoA dehydrogenase
C380_RS03340	COG0183	Belongs to the thiolase family
C380_RS03350	COG1960	acyl-CoA dehydrogenase activity
C380_RS03360	COG1022	Amp-dependent synthetase and ligase
C380_RS03385	COG1024	Enoyl-CoA hydratase
C380_RS03405	COG5265	(ABC) transporter
C380_RS03410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C380_RS03420	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C380_RS03425	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C380_RS03425	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C380_RS03435	COG0583	DNA-binding transcription factor activity
C380_RS03445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C380_RS03450	COG0765	amino acid transport
C380_RS03455	COG0765	amino acid transport
C380_RS03460	COG1126	abc transporter atp-binding protein
C380_RS03475	COG3181	Tripartite tricarboxylate transporter family receptor
C380_RS03480	COG0418	dihydroorotase activity
C380_RS03490	COG0501	Belongs to the peptidase M48B family
C380_RS03495	COG0840	transmembrane signaling receptor activity
C380_RS03500	COG0471	metal ion transport
C380_RS03510	COG1473	amidohydrolase
C380_RS03520	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C380_RS03525	COG0392	lysyltransferase activity
C380_RS03530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C380_RS03535	COG3568	Endonuclease Exonuclease Phosphatase
C380_RS03550	COG3541	Predicted nucleotidyltransferase
C380_RS03555	COG1690	Belongs to the RtcB family
C380_RS03575	COG4650	regulator
C380_RS03595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C380_RS03600	COG2814	Major facilitator Superfamily
C380_RS03605	COG0583	DNA-binding transcription factor activity
C380_RS03615	COG0625	glutathione transferase activity
C380_RS03620	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C380_RS03630	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C380_RS03635	COG0681	Belongs to the peptidase S26 family
C380_RS03640	COG0840	transmembrane signaling receptor activity
C380_RS03645	COG0835	chemotaxis
C380_RS03655	COG0523	cobalamin synthesis protein
C380_RS03670	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C380_RS03675	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C380_RS03680	COG2001	Belongs to the MraZ family
C380_RS03685	COG0275	rRNA processing
C380_RS03700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C380_RS03705	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C380_RS03710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C380_RS03715	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C380_RS03720	COG0772	Belongs to the SEDS family
C380_RS03725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C380_RS03730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C380_RS03735	COG1181	Belongs to the D-alanine--D-alanine ligase family
C380_RS03740	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C380_RS03750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C380_RS03760	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C380_RS03765	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C380_RS03770	COG0840	transmembrane signaling receptor activity
C380_RS03815	COG2165	general secretion pathway protein
C380_RS03835	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C380_RS03840	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C380_RS03845	COG1765	OsmC-like protein
C380_RS03850	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C380_RS03860	COG0747	negative chemotaxis
C380_RS03870	COG1473	amidohydrolase
C380_RS03880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C380_RS03885	COG0444	Belongs to the ABC transporter superfamily
C380_RS03890	COG4608	Belongs to the ABC transporter superfamily
C380_RS03895	COG0583	DNA-binding transcription factor activity
C380_RS03900	COG1250	3-hydroxyacyl-CoA dehydrogenase
C380_RS03900	COG1024	Enoyl-CoA hydratase
C380_RS03905	COG0183	Belongs to the thiolase family
C380_RS03910	COG1960	acyl-CoA dehydrogenase activity
C380_RS03915	COG1960	acyl-CoA dehydrogenase activity
C380_RS03920	COG1024	Enoyl-CoA hydratase
C380_RS03925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C380_RS03940	COG0318	PFAM AMP-dependent synthetase and ligase
C380_RS03965	COG1840	ABC-type Fe3 transport system, periplasmic component
C380_RS03975	COG3842	ATPase activity
C380_RS03980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C380_RS03985	COG0642	Histidine kinase
C380_RS04005	COG1175	transmembrane transport
C380_RS04010	COG0395	ABC-type sugar transport system, permease component
C380_RS04015	COG3842	ATPase activity
C380_RS04020	COG0837	glucose binding
C380_RS04025	COG0346	lactoylglutathione lyase activity
C380_RS04030	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C380_RS04035	COG0166	Belongs to the GPI family
C380_RS04060	COG0800	Aldolase
C380_RS04070	COG0459	protein refolding
C380_RS04075	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C380_RS04080	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C380_RS04085	COG0583	DNA-binding transcription factor activity
C380_RS04090	COG0723	plastoquinol--plastocyanin reductase activity
C380_RS04100	COG3604	Transcriptional regulator
C380_RS04105	COG1309	transcriptional regulator
C380_RS04110	COG0493	'glutamate synthase
C380_RS04120	COG1953	Uracil, thiamine, allantoin
C380_RS04135	COG1051	belongs to the nudix hydrolase family
C380_RS04135	COG1056	cytidyltransferase-related domain
C380_RS04140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C380_RS04140	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C380_RS04145	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C380_RS04175	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C380_RS04185	COG1560	Kdo2-lipid A biosynthetic process
C380_RS04195	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C380_RS04205	COG1333	cytochrome c biogenesis protein
C380_RS04210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C380_RS04215	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C380_RS04220	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C380_RS04230	COG1965	Belongs to the frataxin family
C380_RS04260	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C380_RS04265	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C380_RS04285	COG0069	glutamate synthase activity
C380_RS04285	COG0070	glutamate synthase
C380_RS04285	COG0067	glutamate synthase
C380_RS04295	COG1127	ABC transporter
C380_RS04300	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C380_RS04305	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C380_RS04310	COG2853	Lipoprotein
C380_RS04325	COG1131	(ABC) transporter
C380_RS04330	COG0842	Transport permease protein
C380_RS04335	COG5007	Belongs to the BolA IbaG family
C380_RS04340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C380_RS04345	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C380_RS04370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C380_RS04375	COG0131	Imidazoleglycerol-phosphate dehydratase
C380_RS04385	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C380_RS04390	COG0107	imidazoleglycerol-phosphate synthase activity
C380_RS04395	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C380_RS04400	COG0140	phosphoribosyl-ATP diphosphatase activity
C380_RS04420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C380_RS04425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C380_RS04430	COG0805	protein transport
C380_RS04435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C380_RS04440	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C380_RS04445	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C380_RS04450	COG1970	mechanosensitive ion channel activity
C380_RS04455	COG0723	plastoquinol--plastocyanin reductase activity
C380_RS04460	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C380_RS04465	COG2857	Cytochrome c1
C380_RS04470	COG0625	glutathione transferase activity
C380_RS04475	COG2969	positive regulation of protein catabolic process
C380_RS04490	COG0739	heme binding
C380_RS04495	COG0653	protein targeting
C380_RS04500	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C380_RS04510	COG0494	nUDIX hydrolase
C380_RS04515	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C380_RS04520	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C380_RS04525	COG0237	dephospho-CoA kinase activity
C380_RS04550	COG0142	geranyltranstransferase activity
C380_RS04555	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C380_RS04560	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C380_RS04565	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C380_RS04570	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C380_RS04575	COG0494	nUDIX hydrolase
C380_RS04580	COG0442	prolyl-tRNA aminoacylation
C380_RS04585	COG0741	lytic transglycosylase activity
C380_RS04590	COG1253	flavin adenine dinucleotide binding
C380_RS04595	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C380_RS04600	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C380_RS04605	COG2890	protein-(glutamine-N5) methyltransferase activity
C380_RS04610	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C380_RS04615	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C380_RS04630	COG0584	glycerophosphoryl diester phosphodiesterase
C380_RS04640	COG3842	ATPase activity
C380_RS04645	COG0395	ABC-type sugar transport system, permease component
C380_RS04650	COG1175	transmembrane transport
C380_RS04655	COG1653	transport
C380_RS04660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C380_RS04680	COG2226	methyltransferase
C380_RS04695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C380_RS04715	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C380_RS04730	COG0745	RESPONSE REGULATOR receiver
C380_RS04740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C380_RS04745	COG0302	gtp cyclohydrolase
C380_RS04770	COG0588	phosphoglycerate mutase activity
C380_RS04790	COG0154	amidase activity
C380_RS04795	COG0747	negative chemotaxis
C380_RS04800	COG4608	Belongs to the ABC transporter superfamily
C380_RS04810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C380_RS04815	COG0601	transmembrane transport
C380_RS04820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C380_RS04825	COG0193	aminoacyl-tRNA hydrolase activity
C380_RS04830	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C380_RS04835	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C380_RS04845	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C380_RS04850	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C380_RS04860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C380_RS04875	COG1660	Displays ATPase and GTPase activities
C380_RS04880	COG0497	DNA recombination
C380_RS04885	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C380_RS04890	COG1420	regulation of RNA biosynthetic process
C380_RS04910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C380_RS04915	COG1758	RNA polymerase activity
C380_RS04920	COG0194	GDP metabolic process
C380_RS04925	COG1561	YicC-like family, N-terminal region
C380_RS04945	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C380_RS04950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C380_RS04960	COG5001	Diguanylate cyclase
C380_RS04960	COG3300	MHYT domain
C380_RS04995	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C380_RS05000	COG0830	nickel cation binding
C380_RS05005	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C380_RS05010	COG0454	-acetyltransferase
C380_RS05015	COG0804	urea catabolic process
C380_RS05020	COG0832	Belongs to the urease beta subunit family
C380_RS05030	COG0831	urea catabolic process
C380_RS05080	COG2814	Major facilitator Superfamily
C380_RS05115	COG1597	lipid kinase activity
C380_RS05135	COG0436	Aminotransferase
C380_RS05160	COG0829	nickel cation binding
C380_RS05170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C380_RS05195	COG0402	S-adenosylhomocysteine deaminase activity
C380_RS05245	COG3622	Belongs to the hyi family
C380_RS05255	COG0235	Class ii aldolase
C380_RS05260	COG3395	kinase activity
C380_RS05265	COG2084	Dehydrogenase
C380_RS05270	COG2610	gluconate transmembrane transporter activity
C380_RS05275	COG2186	Transcriptional regulator
C380_RS05280	COG1752	Esterase of the alpha-beta hydrolase superfamily
C380_RS05295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C380_RS05310	COG0280	phosphate acetyltransferase
C380_RS05310	COG0281	malic enzyme
C380_RS05315	COG2233	PERMEase
C380_RS05320	COG2186	Transcriptional regulator
C380_RS05325	COG1301	dicarboxylic acid transport
C380_RS05330	COG0405	Gamma-glutamyltransferase
C380_RS05350	COG2186	Transcriptional regulator
C380_RS05375	COG5001	Diguanylate cyclase
C380_RS05375	COG3300	MHYT domain
C380_RS05395	COG3706	GGDEF domain
C380_RS05400	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C380_RS05415	COG3845	ABC transporter
C380_RS05420	COG4603	Belongs to the binding-protein-dependent transport system permease family
C380_RS05440	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C380_RS05445	COG0537	adenosine 5'-monophosphoramidase activity
C380_RS05455	COG0402	S-adenosylhomocysteine deaminase activity
C380_RS05465	COG0717	Belongs to the dCTP deaminase family
C380_RS05485	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C380_RS05490	COG2321	neutral zinc metallopeptidase
C380_RS05495	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C380_RS05495	COG2066	Belongs to the glutaminase family
C380_RS05500	COG2346	COG2346, Truncated hemoglobins
C380_RS05505	COG1704	LemA family
C380_RS05510	COG0501	Belongs to the peptidase M48B family
C380_RS05530	COG0737	Belongs to the 5'-nucleotidase family
C380_RS05540	COG2003	Belongs to the UPF0758 family
C380_RS05545	COG1047	Peptidyl-prolyl cis-trans
C380_RS05550	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C380_RS05555	COG0517	IMP dehydrogenase activity
C380_RS05555	COG0617	tRNA 3'-terminal CCA addition
C380_RS05555	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C380_RS05560	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C380_RS05565	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C380_RS05615	COG5002	protein histidine kinase activity
C380_RS05625	COG1677	Flagellar hook-basal body complex protein FliE
C380_RS05640	COG0789	Transcriptional regulator
C380_RS05710	COG0789	Transcriptional regulator
C380_RS05720	COG0671	phosphoesterase, PA-phosphatase related
C380_RS05725	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C380_RS05730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C380_RS05750	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C380_RS05755	COG3339	Conserved Protein
C380_RS05805	COG2814	Major facilitator Superfamily
C380_RS05810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C380_RS05810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C380_RS05825	COG0582	viral genome integration into host DNA
C380_RS05830	COG0582	viral genome integration into host DNA
C380_RS05835	COG4974	Belongs to the 'phage' integrase family
C380_RS05840	COG2010	Cytochrome c
C380_RS05895	COG0583	DNA-binding transcription factor activity
C380_RS05900	COG4974	Belongs to the 'phage' integrase family
C380_RS05905	COG0582	viral genome integration into host DNA
C380_RS05910	COG0582	viral genome integration into host DNA
C380_RS05915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C380_RS05920	COG0582	viral genome integration into host DNA
C380_RS05925	COG0582	viral genome integration into host DNA
C380_RS05930	COG4974	Belongs to the 'phage' integrase family
C380_RS05965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C380_RS05985	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C380_RS05990	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C380_RS06000	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C380_RS06015	COG2217	Heavy metal translocating P-type atpase
C380_RS06020	COG2326	polyphosphate kinase activity
C380_RS06070	COG1677	Flagellar hook-basal body complex protein FliE
C380_RS06115	COG2132	Multicopper oxidase
C380_RS06130	COG2801	Transposase and inactivated derivatives
C380_RS06270	COG0582	viral genome integration into host DNA
C380_RS06320	COG0740	serine-type endopeptidase activity
C380_RS06325	COG0709	Synthesizes selenophosphate from selenide and ATP
C380_RS06330	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C380_RS06345	COG0745	RESPONSE REGULATOR receiver
C380_RS06360	COG0180	Tryptophanyl-tRNA synthetase
C380_RS06365	COG1994	Peptidase M50
C380_RS06375	COG0009	L-threonylcarbamoyladenylate synthase
C380_RS06380	COG0613	PHP domain protein
C380_RS06385	COG0840	transmembrane signaling receptor activity
C380_RS06410	COG4591	ABC-type transport system involved in lipoprotein release permease component
C380_RS06415	COG1136	(ABC) transporter
C380_RS06430	COG0714	Associated with various cellular activities
C380_RS06435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C380_RS06440	COG0084	hydrolase, TatD family'
C380_RS06455	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C380_RS06490	COG1028	Short-chain dehydrogenase reductase Sdr
C380_RS06495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C380_RS06505	COG0697	spore germination
C380_RS06520	COG1091	dTDP-4-dehydrorhamnose reductase activity
C380_RS06525	COG0583	DNA-binding transcription factor activity
C380_RS06530	COG0583	DNA-binding transcription factor activity
C380_RS06540	COG1283	sodium-dependent phosphate transmembrane transporter activity
C380_RS06545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C380_RS06550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C380_RS06555	COG0196	riboflavin kinase activity
C380_RS06570	COG1960	acyl-CoA dehydrogenase activity
C380_RS06575	COG1960	acyl-CoA dehydrogenase activity
C380_RS06580	COG3132	Protein of unknown function, DUF480
C380_RS06585	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C380_RS06600	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C380_RS06600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C380_RS06610	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C380_RS06615	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C380_RS06620	COG0492	ferredoxin-NADP+ reductase activity
C380_RS06630	COG1674	ftsk spoiiie
C380_RS06635	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C380_RS06640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C380_RS06650	COG4585	Histidine kinase
C380_RS06685	COG1392	Phosphate transport regulator
C380_RS06690	COG0306	phosphate transporter
C380_RS06705	COG0228	four-way junction DNA binding
C380_RS06710	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C380_RS06715	COG0336	Belongs to the RNA methyltransferase TrmD family
C380_RS06720	COG0335	large ribosomal subunit rRNA binding
C380_RS06730	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C380_RS06735	COG1162	GTPase activity
C380_RS06740	COG2154	pterin-4-alpha-carbinolamine dehydratase
C380_RS06745	COG0501	Belongs to the peptidase M48B family
C380_RS06750	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C380_RS06755	COG0513	Belongs to the DEAD box helicase family
C380_RS06765	COG2814	Major facilitator Superfamily
C380_RS06775	COG2084	Dehydrogenase
C380_RS06785	COG0516	GMP reductase activity
C380_RS06815	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C380_RS06835	COG0625	glutathione transferase activity
C380_RS06855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C380_RS06875	COG5001	Diguanylate cyclase
C380_RS06875	COG4251	negative regulation of phosphorylation
C380_RS06875	COG3706	GGDEF domain
C380_RS06875	COG2203	Gaf domain
C380_RS06880	COG0412	Dienelactone hydrolase
C380_RS06900	COG3275	phosphorelay sensor kinase activity
C380_RS06905	COG0165	Argininosuccinate lyase
C380_RS06925	COG0753	catalase activity
C380_RS06945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C380_RS06950	COG3447	MASE1 domain protein
C380_RS06950	COG5001	Diguanylate cyclase
C380_RS06950	COG5002	protein histidine kinase activity
C380_RS06955	COG1304	FMN binding
C380_RS06965	COG1595	DNA-templated transcription, initiation
C380_RS07005	COG0583	DNA-binding transcription factor activity
C380_RS07010	COG1012	belongs to the aldehyde dehydrogenase family
C380_RS07025	COG0436	Aminotransferase
C380_RS07030	COG0028	Belongs to the TPP enzyme family
C380_RS07035	COG0583	DNA-binding transcription factor activity
C380_RS07040	COG0697	spore germination
C380_RS07045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C380_RS07050	COG0840	transmembrane signaling receptor activity
C380_RS07060	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C380_RS07060	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C380_RS07070	COG3022	response to hydroperoxide
C380_RS07075	COG1530	ribonuclease E activity
C380_RS07095	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C380_RS07095	COG0616	signal peptide processing
C380_RS07100	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C380_RS07105	COG0424	maF-like protein
C380_RS07110	COG1399	metal-binding, possibly nucleic acid-binding protein
C380_RS07115	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C380_RS07120	COG0416	fatty acid biosynthetic process
C380_RS07125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C380_RS07130	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C380_RS07140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C380_RS07145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C380_RS07170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C380_RS07175	COG0481	GTPase activity
C380_RS07180	COG0681	Belongs to the peptidase S26 family
C380_RS07190	COG0571	ribonuclease III activity
C380_RS07195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C380_RS07200	COG1381	Involved in DNA repair and RecF pathway recombination
C380_RS07205	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C380_RS07210	COG0736	holo-[acyl-carrier-protein] synthase activity
C380_RS07215	COG1472	Belongs to the glycosyl hydrolase 3 family
C380_RS07225	COG3706	GGDEF domain
C380_RS07230	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C380_RS07235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C380_RS07240	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C380_RS07270	COG0367	asparagine synthase
C380_RS07275	COG0438	transferase activity, transferring glycosyl groups
C380_RS07295	COG2963	transposase activity
C380_RS07315	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C380_RS07335	COG0762	integral membrane protein
C380_RS07340	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C380_RS07345	COG0159	tryptophan synthase activity
C380_RS07350	COG0133	tryptophan synthase activity
C380_RS07355	COG0135	phosphoribosylanthranilate isomerase activity
C380_RS07360	COG0101	tRNA pseudouridine synthase activity
C380_RS07370	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C380_RS07375	COG0473	3-isopropylmalate dehydrogenase activity
C380_RS07380	COG0066	3-isopropylmalate dehydratase activity
C380_RS07390	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C380_RS07400	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C380_RS07405	COG0484	heat shock protein binding
C380_RS07410	COG0443	Heat shock 70 kDa protein
C380_RS07415	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C380_RS07420	COG0360	Binds together with S18 to 16S ribosomal RNA
C380_RS07430	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C380_RS07435	COG0359	binds to the 23S rRNA
C380_RS07450	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C380_RS07455	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C380_RS07465	COG0436	Aminotransferase
C380_RS07490	COG1763	Mo-molybdopterin cofactor biosynthetic process
C380_RS07505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C380_RS07525	COG0314	molybdopterin synthase activity
C380_RS07535	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C380_RS07540	COG1185	polyribonucleotide nucleotidyltransferase activity
C380_RS07545	COG0604	alcohol dehydrogenase
C380_RS07545	COG3321	synthase
C380_RS07545	COG1028	Short-chain dehydrogenase reductase Sdr
C380_RS07550	COG0149	triose-phosphate isomerase activity
C380_RS07565	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C380_RS07570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C380_RS07575	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C380_RS07580	COG0649	NAD binding
C380_RS07585	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C380_RS07590	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C380_RS07595	COG1034	ATP synthesis coupled electron transport
C380_RS07600	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C380_RS07605	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C380_RS07615	COG0713	ATP synthesis coupled electron transport
C380_RS07630	COG1007	ATP synthesis coupled electron transport
C380_RS07645	COG1132	(ABC) transporter
C380_RS07680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C380_RS07685	COG0583	DNA-binding transcription factor activity
C380_RS07700	COG0071	Belongs to the small heat shock protein (HSP20) family
C380_RS07705	COG4181	ATPase activity
C380_RS07710	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C380_RS07715	COG2814	Major facilitator Superfamily
C380_RS07725	COG0596	Alpha beta hydrolase
C380_RS07730	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C380_RS07740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C380_RS07745	COG0584	glycerophosphoryl diester phosphodiesterase
C380_RS07755	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C380_RS07760	COG0586	Pfam SNARE associated Golgi protein
C380_RS07770	COG0840	transmembrane signaling receptor activity
C380_RS07780	COG0860	N-Acetylmuramoyl-L-alanine amidase
C380_RS07785	COG0802	atpase or kinase
C380_RS07790	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C380_RS07810	COG4974	Belongs to the 'phage' integrase family
C380_RS07820	COG3181	Tripartite tricarboxylate transporter family receptor
C380_RS07825	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C380_RS07830	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C380_RS07835	COG2833	Protein of unknown function (DUF455)
C380_RS07845	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C380_RS07860	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C380_RS07865	COG0148	phosphopyruvate hydratase activity
C380_RS07875	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C380_RS07880	COG0504	CTP synthase activity
C380_RS07885	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C380_RS07895	COG0756	dUTP diphosphatase activity
C380_RS07905	COG1047	Peptidyl-prolyl cis-trans
C380_RS07910	COG2850	peptidyl-arginine hydroxylation
C380_RS07925	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C380_RS07930	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C380_RS07935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C380_RS07955	COG0741	lytic transglycosylase activity
C380_RS07965	COG0840	transmembrane signaling receptor activity
C380_RS07990	COG2308	Evidence 4 Homologs of previously reported genes of
C380_RS08000	COG4628	conserved protein (DUF2132)
C380_RS08010	COG0657	acetylesterase activity
C380_RS08030	COG0436	Aminotransferase
C380_RS08050	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C380_RS08060	COG4774	siderophore transport
C380_RS08115	COG3634	alkyl hydroperoxide reductase activity
C380_RS08120	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C380_RS08135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C380_RS08155	COG0583	DNA-binding transcription factor activity
C380_RS08160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C380_RS08165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C380_RS08170	COG3181	Tripartite tricarboxylate transporter family receptor
C380_RS08175	COG0840	transmembrane signaling receptor activity
C380_RS08185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C380_RS08195	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C380_RS08205	COG0318	PFAM AMP-dependent synthetase and ligase
C380_RS08230	COG1309	transcriptional regulator
C380_RS08235	COG0604	alcohol dehydrogenase
C380_RS08245	COG0405	Gamma-glutamyltransferase
C380_RS08250	COG3540	Alkaline phosphatase
C380_RS08265	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C380_RS08270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C380_RS08280	COG0564	pseudouridine synthase activity
C380_RS08285	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C380_RS08290	COG1187	pseudouridine synthase activity
C380_RS08295	COG0105	UTP biosynthetic process
C380_RS08300	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C380_RS08315	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C380_RS08320	COG0124	histidyl-tRNA synthetase
C380_RS08330	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C380_RS08335	COG1160	GTP binding
C380_RS08340	COG1923	regulation of RNA biosynthetic process
C380_RS08345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C380_RS08350	COG0330	HflC and HflK could
C380_RS08355	COG0330	HflC and HflK could
C380_RS08370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C380_RS08405	COG1187	pseudouridine synthase activity
C380_RS08435	COG0174	glutamine synthetase
C380_RS08445	COG3852	Histidine kinase
C380_RS08450	COG2204	response regulator
C380_RS08460	COG0708	Exodeoxyribonuclease III
C380_RS08485	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C380_RS08715	COG3728	DNA packaging
C380_RS08715	COG5484	DNA packaging
C380_RS08850	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C380_RS08860	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C380_RS08880	COG1175	transmembrane transport
C380_RS08885	COG0395	ABC-type sugar transport system, permease component
C380_RS08900	COG0246	Mannitol dehydrogenase
C380_RS08905	COG2207	Transcriptional regulator
C380_RS08910	COG1070	Carbohydrate kinase
C380_RS08925	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C380_RS08925	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C380_RS08940	COG0277	FAD linked oxidase domain protein
C380_RS08950	COG1295	ribonuclease BN
C380_RS08960	COG2267	carboxylic ester hydrolase activity
C380_RS08980	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C380_RS08995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C380_RS09000	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C380_RS09005	COG0741	lytic transglycosylase activity
C380_RS09035	COG0557	exoribonuclease II activity
C380_RS09050	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C380_RS09050	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C380_RS09055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C380_RS09065	COG0052	Belongs to the universal ribosomal protein uS2 family
C380_RS09070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C380_RS09075	COG0528	UMP kinase activity
C380_RS09080	COG0233	cytoplasmic translational termination
C380_RS09095	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C380_RS09100	COG0750	zinc metalloprotease
C380_RS09115	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C380_RS09120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C380_RS09125	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C380_RS09130	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C380_RS09135	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C380_RS09140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C380_RS09145	COG0505	Belongs to the CarA family
C380_RS09150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C380_RS09155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C380_RS09170	COG1534	Rna-binding protein
C380_RS09175	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C380_RS09180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C380_RS09185	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C380_RS09190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C380_RS09235	COG0248	Ppx GppA phosphatase
C380_RS09240	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C380_RS09245	COG0573	inorganic phosphate transmembrane transporter activity
C380_RS09250	COG0581	inorganic phosphate transmembrane transporter activity
C380_RS09255	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C380_RS09265	COG0745	RESPONSE REGULATOR receiver
C380_RS09275	COG0534	Mate efflux family protein
C380_RS09285	COG0254	rRNA binding
C380_RS09290	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C380_RS09305	COG1074	ATP-dependent DNA helicase activity
C380_RS09310	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
C380_RS09315	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C380_RS09320	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C380_RS09325	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C380_RS09340	COG1388	LysM domain
C380_RS09340	COG0741	lytic transglycosylase activity
C380_RS09345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C380_RS09355	COG0328	RNA-DNA hybrid ribonuclease activity
C380_RS09360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C380_RS09365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C380_RS09375	COG0303	'Molybdopterin
C380_RS09385	COG0746	molybdenum cofactor guanylyltransferase activity
C380_RS09390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C380_RS09480	COG1773	rubredoxin
C380_RS09535	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C380_RS09550	COG0835	chemotaxis
C380_RS09555	COG0840	transmembrane signaling receptor activity
C380_RS09565	COG0840	transmembrane signaling receptor activity
C380_RS09580	COG0347	Belongs to the P(II) protein family
C380_RS09590	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C380_RS09615	COG0028	Belongs to the TPP enzyme family
C380_RS09620	COG0440	acetolactate synthase activity
C380_RS09625	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C380_RS09630	COG1183	phosphatidylcholine synthase activity
C380_RS09635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C380_RS09645	COG1414	Transcriptional regulator
C380_RS09650	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C380_RS09655	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C380_RS09905	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C380_RS09930	COG0242	peptide deformylase activity
C380_RS09935	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C380_RS09940	COG0024	Methionine aminopeptidase
C380_RS09945	COG0047	phosphoribosylformylglycinamidine synthase activity
C380_RS09945	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C380_RS09975	COG2354	Protein conserved in bacteria
C380_RS09980	COG3047	cAMP biosynthetic process
C380_RS09985	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C380_RS09990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C380_RS10000	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C380_RS10005	COG0826	peptidase U32
C380_RS10025	COG1619	proteins homologs of microcin C7 resistance protein MccF
C380_RS10080	COG1024	Enoyl-CoA hydratase
C380_RS10085	COG1250	3-hydroxyacyl-CoA dehydrogenase
C380_RS10100	COG2022	thiamine diphosphate biosynthetic process
C380_RS10115	COG0351	phosphomethylpyrimidine kinase
C380_RS10125	COG0492	ferredoxin-NADP+ reductase activity
C380_RS10130	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C380_RS10135	COG2895	sulfate adenylyltransferase (ATP) activity
C380_RS10135	COG0529	Catalyzes the synthesis of activated sulfate
C380_RS10140	COG0175	sulfate reduction
C380_RS10160	COG0730	response to heat
C380_RS10165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C380_RS10165	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C380_RS10170	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C380_RS10175	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C380_RS10180	COG0431	NADPH-dependent FMN reductase
C380_RS10185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C380_RS10190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C380_RS10200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C380_RS10205	COG1116	anion transmembrane transporter activity
C380_RS10215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C380_RS10230	COG2175	clavaminate synthase activity
C380_RS10240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C380_RS10245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C380_RS10255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C380_RS10260	COG3119	arylsulfatase activity
C380_RS10265	COG0583	DNA-binding transcription factor activity
C380_RS10275	COG0583	DNA-binding transcription factor activity
C380_RS10285	COG0165	Argininosuccinate lyase
C380_RS10300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C380_RS10300	COG4221	oxidoreductase activity
C380_RS10300	COG3321	synthase
C380_RS10300	COG0604	alcohol dehydrogenase
C380_RS10325	COG0642	Histidine kinase
C380_RS10355	COG4974	Belongs to the 'phage' integrase family
C380_RS10360	COG0582	viral genome integration into host DNA
C380_RS10365	COG0582	viral genome integration into host DNA
C380_RS10390	COG4948	Mandelate Racemase Muconate Lactonizing
C380_RS10395	COG0800	Aldolase
C380_RS10400	COG3734	2-keto-3-deoxy-galactonokinase
C380_RS10415	COG1172	Belongs to the binding-protein-dependent transport system permease family
C380_RS10420	COG1172	Belongs to the binding-protein-dependent transport system permease family
C380_RS10430	COG4214	carbohydrate transport
C380_RS10440	COG4213	ABC transporter substrate-binding protein
C380_RS10445	COG1879	ABC-type sugar transport system periplasmic component
C380_RS10450	COG1012	belongs to the aldehyde dehydrogenase family
C380_RS10465	COG3386	PFAM SMP-30 Gluconolaconase
C380_RS10500	COG0583	DNA-binding transcription factor activity
C380_RS10505	COG3550	peptidyl-serine autophosphorylation
C380_RS10520	COG2814	Major facilitator Superfamily
C380_RS10530	COG2814	Major facilitator Superfamily
C380_RS10535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C380_RS10540	COG2011	ABC-type metal ion transport system permease component
C380_RS10545	COG0456	acetyltransferase
C380_RS10545	COG0454	-acetyltransferase
C380_RS10565	COG0583	DNA-binding transcription factor activity
C380_RS10575	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C380_RS10580	COG0789	Transcriptional regulator
C380_RS10595	COG2183	response to ionizing radiation
C380_RS10640	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C380_RS10645	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C380_RS10650	COG0470	DNA polymerase III
C380_RS10660	COG0084	hydrolase, TatD family'
C380_RS10670	COG1132	(ABC) transporter
C380_RS10675	COG0823	Involved in the tonB-independent uptake of proteins
C380_RS10680	COG2885	chlorophyll binding
C380_RS10690	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C380_RS10755	COG2974	May be involved in recombination
C380_RS10845	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C380_RS10850	COG3657	addiction module killer protein
C380_RS10870	COG0628	permease
C380_RS10875	COG0567	Dehydrogenase, E1 component
C380_RS10880	COG0508	dehydrogenase complex catalyzes the overall conversion of
C380_RS10885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C380_RS10890	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C380_RS10900	COG0631	protein serine/threonine phosphatase activity
C380_RS10910	COG1199	ATP-dependent helicase activity
C380_RS10925	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C380_RS10930	COG0542	response to heat
C380_RS10935	COG2982	Protein involved in outer membrane biogenesis
C380_RS10940	COG0564	pseudouridine synthase activity
C380_RS10955	COG1177	transmembrane transport
C380_RS10960	COG1176	ABC-type spermidine putrescine transport system, permease component I
C380_RS10970	COG3842	ATPase activity
C380_RS10975	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C380_RS10980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C380_RS10985	COG1802	Transcriptional regulator
C380_RS10990	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C380_RS10995	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C380_RS11025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C380_RS11030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C380_RS11035	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C380_RS11040	COG3706	GGDEF domain
C380_RS11045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C380_RS11050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C380_RS11060	COG0583	DNA-binding transcription factor activity
C380_RS11065	COG1741	Belongs to the pirin family
C380_RS11070	COG2259	Doxx family
C380_RS11085	COG1741	Belongs to the pirin family
C380_RS11090	COG1054	Belongs to the UPF0176 family
C380_RS11130	COG4181	ATPase activity
C380_RS11135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C380_RS11140	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C380_RS11165	COG0179	Fumarylacetoacetate (FAA) hydrolase
C380_RS11180	COG3550	peptidyl-serine autophosphorylation
C380_RS11195	COG3048	D-serine ammonia-lyase activity
C380_RS11205	COG0154	amidase activity
C380_RS11220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C380_RS11225	COG1739	Uncharacterized protein family UPF0029
C380_RS11240	COG0456	acetyltransferase
C380_RS11240	COG1846	Transcriptional regulator
C380_RS11260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C380_RS11265	COG3384	dioxygenase
C380_RS11280	COG0556	nucleotide-excision repair
C380_RS11285	COG1959	2 iron, 2 sulfur cluster binding
C380_RS11290	COG1104	cysteine desulfurase activity
C380_RS11295	COG0822	iron-sulfur transferase activity
C380_RS11310	COG0443	Heat shock 70 kDa protein
C380_RS11340	COG0579	oxidoreductase
C380_RS11360	COG0167	dihydroorotate dehydrogenase activity
C380_RS11365	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C380_RS11380	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C380_RS11385	COG4566	intracellular signal transduction
C380_RS11395	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C380_RS11400	COG0508	dehydrogenase complex catalyzes the overall conversion of
C380_RS11405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C380_RS11415	COG0527	aspartate kinase activity
C380_RS11425	COG1850	ribulose-bisphosphate carboxylase activity
C380_RS11435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C380_RS11440	COG1126	abc transporter atp-binding protein
C380_RS11445	COG0765	amino acid transport
C380_RS11450	COG0765	amino acid transport
C380_RS11460	COG0697	spore germination
C380_RS11465	COG0583	DNA-binding transcription factor activity
C380_RS11470	COG1349	DNA-binding transcription factor activity
C380_RS11475	COG0494	nUDIX hydrolase
C380_RS11480	COG2366	antibiotic biosynthetic process
C380_RS11485	COG4977	sequence-specific DNA binding
C380_RS11490	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C380_RS11525	COG2169	Transcriptional regulator
C380_RS11525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C380_RS11575	COG0791	NLP P60 protein
C380_RS11580	COG2133	pyrroloquinoline quinone binding
C380_RS11585	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C380_RS11590	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C380_RS11605	COG1473	amidohydrolase
C380_RS11610	COG2066	Belongs to the glutaminase family
C380_RS11670	COG1538	Outer membrane efflux protein
C380_RS11680	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C380_RS11690	COG3293	Transposase
C380_RS11710	COG1309	transcriptional regulator
C380_RS11715	COG2188	Transcriptional regulator
C380_RS11750	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C380_RS11755	COG0066	3-isopropylmalate dehydratase activity
C380_RS11785	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C380_RS11795	COG1136	(ABC) transporter
C380_RS11830	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C380_RS11860	COG0642	Histidine kinase
C380_RS11865	COG3842	ATPase activity
C380_RS11885	COG0259	pyridoxamine-phosphate oxidase activity
C380_RS11890	COG1309	transcriptional regulator
C380_RS11925	COG2032	superoxide dismutase activity
C380_RS11940	COG0346	lactoylglutathione lyase activity
C380_RS11970	COG1028	Short-chain dehydrogenase reductase Sdr
C380_RS11980	COG3453	Protein conserved in bacteria
C380_RS11980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C380_RS11995	COG0640	Transcriptional regulator
C380_RS12025	COG0784	Response regulator, receiver
C380_RS12025	COG5002	protein histidine kinase activity
C380_RS12025	COG2205	protein histidine kinase activity
C380_RS12030	COG3437	response regulator, receiver
C380_RS12035	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C380_RS12055	COG4770	biotin carboxylase activity
C380_RS12060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C380_RS12065	COG1703	isobutyryl-CoA mutase activity
C380_RS12070	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C380_RS12070	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C380_RS12075	COG1802	Transcriptional regulator
C380_RS12080	COG1022	Amp-dependent synthetase and ligase
C380_RS12120	COG4626	Terminase
C380_RS12120	COG1802	Transcriptional regulator
C380_RS12175	COG0582	viral genome integration into host DNA
C380_RS12180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C380_RS12205	COG2878	Part of a membrane complex involved in electron transport
C380_RS12210	COG0840	transmembrane signaling receptor activity
C380_RS12215	COG0436	Aminotransferase
C380_RS12220	COG2171	N-acyltransferase activity
C380_RS12230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C380_RS12235	COG2890	protein-(glutamine-N5) methyltransferase activity
C380_RS12240	COG0488	(ABC) transporter
C380_RS12245	COG1028	Short-chain dehydrogenase reductase Sdr
C380_RS12250	COG5001	Diguanylate cyclase
C380_RS12265	COG0183	Belongs to the thiolase family
C380_RS12270	COG3243	poly(R)-hydroxyalkanoic acid synthase
C380_RS12315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C380_RS12325	COG1196	nuclear chromosome segregation
C380_RS12330	COG3706	GGDEF domain
C380_RS12340	COG3800	Transcriptional regulator
C380_RS12340	COG1396	sequence-specific DNA binding
C380_RS12385	COG1132	(ABC) transporter
C380_RS12410	COG2706	6-phosphogluconolactonase activity
C380_RS12415	COG3181	Tripartite tricarboxylate transporter family receptor
C380_RS12420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C380_RS12430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C380_RS12450	COG0583	DNA-binding transcription factor activity
C380_RS12455	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C380_RS12460	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C380_RS12470	COG1538	Outer membrane efflux protein
C380_RS12475	COG1566	PFAM secretion protein HlyD family protein
C380_RS12480	COG2814	Major facilitator Superfamily
C380_RS12500	COG1051	belongs to the nudix hydrolase family
C380_RS12515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C380_RS12550	COG1960	acyl-CoA dehydrogenase activity
C380_RS12580	COG2205	protein histidine kinase activity
C380_RS12580	COG3850	Histidine kinase
C380_RS12580	COG3437	response regulator, receiver
C380_RS12580	COG4999	Histidine kinase
C380_RS12600	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C380_RS12605	COG1570	exodeoxyribonuclease VII activity
C380_RS12610	COG0811	peptide transport
C380_RS12615	COG0848	biopolymer transport protein
C380_RS12620	COG2835	tetraacyldisaccharide 4'-kinase activity
C380_RS12620	COG1663	tetraacyldisaccharide 4'-kinase activity
C380_RS12625	COG2835	tetraacyldisaccharide 4'-kinase activity
C380_RS12630	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C380_RS12635	COG0563	adenylate kinase activity
C380_RS12650	COG0252	asparaginase activity
C380_RS12655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C380_RS12660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C380_RS12690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C380_RS12710	COG0583	DNA-binding transcription factor activity
C380_RS12715	COG0436	Aminotransferase
C380_RS12730	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C380_RS12735	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C380_RS12740	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C380_RS12745	COG2205	protein histidine kinase activity
C380_RS12750	COG0745	RESPONSE REGULATOR receiver
C380_RS12760	COG0625	glutathione transferase activity
C380_RS12765	COG1530	ribonuclease E activity
C380_RS12770	COG0424	maF-like protein
C380_RS12775	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C380_RS12780	COG0799	negative regulation of ribosome biogenesis
C380_RS12785	COG0408	coproporphyrinogen oxidase activity
C380_RS12790	COG0151	Belongs to the GarS family
C380_RS12795	COG0217	transcriptional regulatory protein
C380_RS12800	COG0433	COG0433 Predicted ATPase
C380_RS12815	COG1473	amidohydrolase
C380_RS12820	COG3181	Tripartite tricarboxylate transporter family receptor
C380_RS12835	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C380_RS12840	COG1744	ABC transporter substrate-binding protein PnrA-like
C380_RS12850	COG3845	ABC transporter
C380_RS12860	COG4603	Belongs to the binding-protein-dependent transport system permease family
C380_RS12865	COG1079	Belongs to the binding-protein-dependent transport system permease family
C380_RS12875	COG0402	S-adenosylhomocysteine deaminase activity
C380_RS12885	COG0842	Transport permease protein
C380_RS12890	COG0842	Transport permease protein
C380_RS12890	COG1129	ABC transporter
C380_RS12895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C380_RS12905	COG3706	GGDEF domain
C380_RS12925	COG0484	heat shock protein binding
C380_RS12930	COG0217	transcriptional regulatory protein
C380_RS12935	COG0700	Nucleoside recognition
C380_RS12940	COG2815	serine threonine protein kinase
C380_RS12940	COG0515	serine threonine protein kinase
C380_RS12950	COG2925	Exonuclease
C380_RS12955	COG2951	lytic endotransglycosylase activity
C380_RS12965	COG0587	DNA-directed DNA polymerase activity
C380_RS12980	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C380_RS12995	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C380_RS13010	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C380_RS13015	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C380_RS13020	COG3386	PFAM SMP-30 Gluconolaconase
C380_RS13045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C380_RS13050	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C380_RS13065	COG3181	Tripartite tricarboxylate transporter family receptor
C380_RS13100	COG1028	Short-chain dehydrogenase reductase Sdr
C380_RS13130	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C380_RS13130	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C380_RS13140	COG1643	Atp-dependent helicase
C380_RS13145	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C380_RS13155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C380_RS13160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C380_RS13160	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C380_RS13175	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C380_RS13180	COG1054	Belongs to the UPF0176 family
C380_RS13195	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C380_RS13200	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C380_RS13205	COG4208	sulfate ABC transporter
C380_RS13215	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C380_RS13230	COG1595	DNA-templated transcription, initiation
C380_RS13245	COG0583	DNA-binding transcription factor activity
C380_RS13250	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C380_RS13290	COG2203	Gaf domain
C380_RS13290	COG3706	GGDEF domain
C380_RS13290	COG4251	negative regulation of phosphorylation
C380_RS13290	COG5001	Diguanylate cyclase
C380_RS13310	COG1960	acyl-CoA dehydrogenase activity
C380_RS13315	COG2153	protein acetylation
C380_RS13320	COG2130	NADP-dependent
C380_RS13330	COG1028	Short-chain dehydrogenase reductase Sdr
C380_RS13340	COG1960	acyl-CoA dehydrogenase activity
C380_RS13350	COG0183	Belongs to the thiolase family
C380_RS13355	COG1250	3-hydroxyacyl-CoA dehydrogenase
C380_RS13355	COG1024	Enoyl-CoA hydratase
C380_RS13365	COG0411	ABC transporter
C380_RS13375	COG0559	Belongs to the binding-protein-dependent transport system permease family
C380_RS13385	COG0318	PFAM AMP-dependent synthetase and ligase
C380_RS13390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C380_RS13395	COG2272	Belongs to the type-B carboxylesterase lipase family
C380_RS13400	COG2207	Transcriptional regulator
C380_RS13405	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C380_RS13410	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C380_RS13415	COG2917	probably involved in intracellular septation
C380_RS13425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C380_RS13440	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C380_RS13445	COG0517	IMP dehydrogenase activity
C380_RS13465	COG0411	ABC transporter
C380_RS13475	COG0688	phosphatidylethanolamine metabolic process
C380_RS13495	COG1228	amidohydrolase
C380_RS13510	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C380_RS13515	COG2986	histidine ammonia-lyase
C380_RS13530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C380_RS13535	COG2358	TRAP transporter, solute receptor (TAXI family
C380_RS13540	COG3850	Histidine kinase
C380_RS13540	COG5002	protein histidine kinase activity
C380_RS13545	COG0745	RESPONSE REGULATOR receiver
C380_RS13565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C380_RS13580	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C380_RS13585	COG1605	Chorismate mutase
C380_RS13585	COG0077	Prephenate dehydratase
C380_RS13590	COG0287	Prephenate dehydrogenase
C380_RS13595	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C380_RS13605	COG0776	regulation of translation
C380_RS13615	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C380_RS13625	COG2111	Na H antiporter
C380_RS13625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C380_RS13630	COG1006	Multisubunit Na H antiporter MnhC subunit
C380_RS13635	COG0651	ATP synthesis coupled electron transport
C380_RS13640	COG1863	multisubunit Na H antiporter MnhE subunit
C380_RS13645	COG2212	antiporter activity
C380_RS13650	COG1320	monovalent cation:proton antiporter activity
C380_RS13680	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C380_RS13710	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C380_RS13720	COG0123	including yeast histone deacetylase and acetoin utilization protein
C380_RS13730	COG1840	ABC-type Fe3 transport system, periplasmic component
C380_RS13760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C380_RS13780	COG0285	dihydrofolate synthase activity
C380_RS13785	COG1393	Belongs to the ArsC family
C380_RS13795	COG3123	guanosine phosphorylase activity
C380_RS13800	COG0137	argininosuccinate synthase activity
C380_RS13805	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C380_RS13810	COG1666	GTP binding
C380_RS13815	COG3577	Aspartyl protease
C380_RS13825	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C380_RS13830	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C380_RS13835	COG0583	DNA-binding transcription factor activity
C380_RS13840	COG3181	Tripartite tricarboxylate transporter family receptor
C380_RS13850	COG0667	Aldo Keto reductase
C380_RS13855	COG2267	carboxylic ester hydrolase activity
C380_RS13860	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C380_RS13865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C380_RS13870	COG0308	aminopeptidase N
C380_RS13875	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C380_RS13900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C380_RS13915	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C380_RS13925	COG1205	dead DEAH box helicase
C380_RS13925	COG1111	helicase
C380_RS13995	COG0582	viral genome integration into host DNA
C380_RS14000	COG0582	viral genome integration into host DNA
C380_RS14010	COG3039	Transposase
C380_RS14035	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C380_RS14160	COG0582	viral genome integration into host DNA
C380_RS14185	COG0789	Transcriptional regulator
C380_RS14190	COG0776	regulation of translation
C380_RS14195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C380_RS14195	COG0072	phenylalanine-tRNA ligase activity
C380_RS14200	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C380_RS14205	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C380_RS14210	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C380_RS14215	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C380_RS14220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C380_RS14240	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C380_RS14250	COG4774	siderophore transport
C380_RS14255	COG3128	pkhd-type hydroxylase
C380_RS14290	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C380_RS14295	COG0670	Belongs to the BI1 family
C380_RS14305	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C380_RS14320	COG0506	proline dehydrogenase activity
C380_RS14320	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C380_RS14320	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C380_RS14375	COG3504	Conjugal transfer protein
C380_RS14395	COG3451	type IV secretory pathway VirB4
C380_RS14405	COG3838	Conjugal transfer protein Trbc
C380_RS14410	COG4962	Type ii secretion system protein e
C380_RS14430	COG0583	DNA-binding transcription factor activity
C380_RS14445	COG1960	acyl-CoA dehydrogenase activity
C380_RS14450	COG2814	Major facilitator Superfamily
C380_RS14475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C380_RS14480	COG0318	PFAM AMP-dependent synthetase and ligase
C380_RS14485	COG0183	Belongs to the thiolase family
C380_RS14490	COG1024	Enoyl-CoA hydratase
C380_RS14510	COG4959	Type IV secretory pathway protease TraF
C380_RS14525	COG1192	Involved in chromosome partitioning
C380_RS14555	COG5489	Protein of unknown function (DUF736)
C380_RS14615	COG0537	adenosine 5'-monophosphoramidase activity
C380_RS14625	COG0514	ATP-dependent DNA helicase (RecQ)
C380_RS14650	COG0582	viral genome integration into host DNA
C380_RS14655	COG0519	Catalyzes the synthesis of GMP from XMP
C380_RS14655	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C380_RS14680	COG2914	Belongs to the UPF0125 (RnfH) family
C380_RS14685	COG2867	negative regulation of translational initiation
C380_RS14690	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C380_RS14710	COG1024	Enoyl-CoA hydratase
C380_RS14720	COG1217	gtp-binding protein TYPA
C380_RS14725	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C380_RS14730	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C380_RS14735	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C380_RS14740	COG0195	Participates in both transcription termination and antitermination
C380_RS14745	COG0779	Required for maturation of 30S ribosomal subunits
C380_RS14750	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C380_RS14770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C380_RS14825	COG0066	3-isopropylmalate dehydratase activity
C380_RS14840	COG3181	Tripartite tricarboxylate transporter family receptor
C380_RS14845	COG0583	DNA-binding transcription factor activity
C380_RS14855	COG3040	lipid binding
C380_RS14860	COG4172	Belongs to the ABC transporter superfamily
C380_RS14865	COG4239	(ABC) transporter, permease
C380_RS14870	COG4174	ABC transporter (Permease)
C380_RS14875	COG4166	transmembrane transport
C380_RS14885	COG1793	dna ligase
C380_RS14890	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C380_RS14920	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C380_RS14995	COG2132	Multicopper oxidase
C380_RS15000	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
C380_RS15015	COG3191	aminopeptidase activity
C380_RS15050	COG0488	(ABC) transporter
C380_RS15055	COG0513	Belongs to the DEAD box helicase family
C380_RS15060	COG0702	epimerase
C380_RS15075	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C380_RS15075	COG4651	solute:proton antiporter activity
C380_RS15095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C380_RS15105	COG0776	regulation of translation
C380_RS15110	COG0473	3-isopropylmalate dehydrogenase activity
C380_RS15115	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C380_RS15120	COG0322	excinuclease ABC activity
C380_RS15130	COG3293	Transposase
C380_RS15145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C380_RS15150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C380_RS15155	COG0583	DNA-binding transcription factor activity
C380_RS15165	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C380_RS15170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C380_RS15185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C380_RS15195	COG1028	Short-chain dehydrogenase reductase Sdr
C380_RS15220	COG3181	Tripartite tricarboxylate transporter family receptor
C380_RS15225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C380_RS15230	COG1609	Transcriptional regulator
C380_RS15235	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C380_RS15240	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C380_RS15240	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C380_RS15245	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C380_RS15260	COG0024	Methionine aminopeptidase
C380_RS15270	COG0560	Phosphoserine phosphatase
C380_RS15275	COG1959	2 iron, 2 sulfur cluster binding
C380_RS15300	COG0023	Translation Initiation Factor
C380_RS15310	COG0513	Belongs to the DEAD box helicase family
C380_RS15335	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C380_RS15350	COG0446	pyridine nucleotide-disulphide oxidoreductase
C380_RS15350	COG1902	pentaerythritol trinitrate reductase activity
C380_RS15360	COG2900	Belongs to the SlyX family
C380_RS15365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C380_RS15380	COG3181	Tripartite tricarboxylate transporter family receptor
C380_RS15385	COG0154	amidase activity
C380_RS15390	COG0583	DNA-binding transcription factor activity
C380_RS15395	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C380_RS15400	COG3654	unkown
C380_RS15415	COG1802	Transcriptional regulator
C380_RS15420	COG3833	ABC-type maltose transport systems, permease component
C380_RS15425	COG1176	ABC-type spermidine putrescine transport system, permease component I
C380_RS15445	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C380_RS15455	COG1492	cobalamin metabolic process
C380_RS15470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C380_RS15475	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C380_RS15480	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C380_RS15485	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C380_RS15490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C380_RS15495	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C380_RS15510	COG4206	TonB-dependent receptor
C380_RS15525	COG0730	response to heat
C380_RS15535	COG2199	diguanylate cyclase activity
C380_RS15535	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C380_RS15550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C380_RS15585	COG3278	Belongs to the heme-copper respiratory oxidase family
C380_RS15595	COG2217	Heavy metal translocating P-type atpase
C380_RS15605	COG0318	PFAM AMP-dependent synthetase and ligase
C380_RS15625	COG1802	Transcriptional regulator
C380_RS15640	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C380_RS15650	COG0129	dihydroxy-acid dehydratase activity
C380_RS15660	COG4654	Cytochrome c, class I
C380_RS15670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C380_RS15690	COG2205	protein histidine kinase activity
C380_RS15695	COG0745	RESPONSE REGULATOR receiver
C380_RS15705	COG0114	fumarate hydratase activity
C380_RS15720	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C380_RS15725	COG1451	nucleotide metabolic process
C380_RS15775	COG2003	Belongs to the UPF0758 family
C380_RS15795	COG1475	DNA binding
C380_RS15810	COG1695	Transcriptional regulator
C380_RS15815	COG1393	Belongs to the ArsC family
C380_RS15820	COG0798	PFAM Bile acid sodium symporter
C380_RS15835	COG0640	Transcriptional regulator
C380_RS15840	COG5489	Protein of unknown function (DUF736)
C380_RS15870	COG1192	Involved in chromosome partitioning
C380_RS15900	COG3039	Transposase
C380_RS15905	COG3971	2-oxopent-4-enoate hydratase activity
C380_RS15910	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C380_RS15965	COG0583	DNA-binding transcription factor activity
C380_RS15985	COG4962	Type ii secretion system protein e
C380_RS15990	COG3838	Conjugal transfer protein Trbc
C380_RS16000	COG3451	type IV secretory pathway VirB4
C380_RS16030	COG2948	multi-organism process
C380_RS16050	COG0210	DNA helicase
C380_RS16075	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C380_RS16080	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C380_RS16085	COG0740	serine-type endopeptidase activity
C380_RS16090	COG0544	peptidyl-prolyl cis-trans isomerase activity
C380_RS16105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C380_RS16110	COG1562	ergosterol biosynthetic process
C380_RS16115	COG1760	l-serine dehydratase
C380_RS16130	COG1562	ergosterol biosynthetic process
C380_RS16150	COG0642	Histidine kinase
C380_RS16175	COG1011	Hydrolase
C380_RS16180	COG1609	Transcriptional regulator
C380_RS16190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C380_RS16200	COG1126	abc transporter atp-binding protein
C380_RS16205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C380_RS16210	COG0765	amino acid transport
C380_RS16215	COG0765	amino acid transport
C380_RS16220	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C380_RS16225	COG1067	ATP-dependent peptidase activity
C380_RS16255	COG1024	Enoyl-CoA hydratase
C380_RS16295	COG1902	pentaerythritol trinitrate reductase activity
C380_RS16300	COG2267	carboxylic ester hydrolase activity
C380_RS16330	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C380_RS16340	COG3046	protein related to deoxyribodipyrimidine photolyase
C380_RS16345	COG0415	Belongs to the DNA photolyase family
C380_RS16350	COG0415	Belongs to the DNA photolyase family
C380_RS16355	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C380_RS16365	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C380_RS16405	COG0411	ABC transporter
C380_RS16420	COG2204	response regulator
C380_RS16455	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C380_RS16465	COG0037	tRNA processing
C380_RS16470	COG0840	transmembrane signaling receptor activity
C380_RS16475	COG0825	malonyl-CoA metabolic process
C380_RS16485	COG0215	cysteine-tRNA ligase activity
C380_RS16510	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C380_RS16515	COG3228	Belongs to the MtfA family
C380_RS16530	COG1522	sequence-specific DNA binding
C380_RS16540	COG1522	sequence-specific DNA binding
C380_RS16550	COG3384	dioxygenase
C380_RS16560	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C380_RS16565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C380_RS16635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C380_RS16710	COG0564	pseudouridine synthase activity
C380_RS16755	COG2814	Major facilitator Superfamily
C380_RS16780	COG2918	glutathione biosynthetic process
C380_RS16785	COG1028	Short-chain dehydrogenase reductase Sdr
C380_RS16810	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C380_RS16815	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C380_RS16820	COG0436	Aminotransferase
C380_RS16825	COG0824	Thioesterase
C380_RS16845	COG0477	Major facilitator Superfamily
C380_RS16855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C380_RS16860	COG1845	cytochrome c oxidase, subunit III
C380_RS16865	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C380_RS16875	COG2205	protein histidine kinase activity
C380_RS16880	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C380_RS16885	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C380_RS16895	COG1049	propionate catabolic process, 2-methylcitrate cycle
C380_RS16910	COG0039	L-malate dehydrogenase activity
C380_RS16915	COG2188	Transcriptional regulator
C380_RS16925	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C380_RS16930	COG1053	succinate dehydrogenase
C380_RS16935	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C380_RS16940	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C380_RS16945	COG0372	Belongs to the citrate synthase family
C380_RS16965	COG0300	oxidoreductase activity
C380_RS16975	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C380_RS16985	COG2194	sulfuric ester hydrolase activity
C380_RS17000	COG2388	GCN5-related N-acetyl-transferase
C380_RS17025	COG1802	Transcriptional regulator
C380_RS17055	COG0574	Belongs to the PEP-utilizing enzyme family
C380_RS17055	COG3848	Pyruvate phosphate dikinase
C380_RS17060	COG0574	Belongs to the PEP-utilizing enzyme family
C380_RS17060	COG3848	Pyruvate phosphate dikinase
C380_RS17080	COG0411	ABC transporter
C380_RS17090	COG3473	Maleate cis-trans isomerase
C380_RS17095	COG0596	Alpha beta hydrolase
C380_RS17100	COG2309	aminopeptidase activity
C380_RS17105	COG1335	isochorismatase
C380_RS17115	COG3181	Tripartite tricarboxylate transporter family receptor
C380_RS17120	COG0165	Argininosuccinate lyase
C380_RS17125	COG0583	DNA-binding transcription factor activity
C380_RS17140	COG0004	ammonium transporteR
C380_RS17145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C380_RS17150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C380_RS17160	COG2813	Specifically methylates the guanine in position
C380_RS17175	COG2197	response regulator
C380_RS17180	COG0784	Response regulator, receiver
C380_RS17180	COG2198	Histidine kinase
C380_RS17180	COG2205	protein histidine kinase activity
C380_RS17195	COG0542	response to heat
C380_RS17245	COG1960	acyl-CoA dehydrogenase activity
C380_RS17260	COG1196	nuclear chromosome segregation
C380_RS17260	COG3264	Mechanosensitive ion channel
C380_RS17265	COG1024	Enoyl-CoA hydratase
C380_RS17275	COG0714	Associated with various cellular activities
C380_RS17290	COG2951	lytic endotransglycosylase activity
C380_RS17295	COG1131	(ABC) transporter
C380_RS17300	COG0842	Transport permease protein
C380_RS17305	COG0683	leucine binding
C380_RS17315	COG0577	efflux transmembrane transporter activity
C380_RS17315	COG1136	(ABC) transporter
C380_RS17320	COG0577	efflux transmembrane transporter activity
C380_RS17320	COG1136	(ABC) transporter
C380_RS17325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C380_RS17365	COG1012	belongs to the aldehyde dehydrogenase family
C380_RS17370	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C380_RS17385	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C380_RS17390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C380_RS17395	COG1116	anion transmembrane transporter activity
C380_RS17400	COG0517	IMP dehydrogenase activity
C380_RS17415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C380_RS17420	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C380_RS17425	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C380_RS17430	COG3265	gluconokinase activity
C380_RS17435	COG1609	Transcriptional regulator
C380_RS17440	COG0840	transmembrane signaling receptor activity
C380_RS17445	COG2223	nitrite transmembrane transporter activity
C380_RS17450	COG2815	serine threonine protein kinase
C380_RS17450	COG0515	serine threonine protein kinase
C380_RS17455	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C380_RS17470	COG0243	molybdopterin cofactor binding
C380_RS17475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C380_RS17490	COG1607	acyl-coa hydrolase
C380_RS17505	COG0683	leucine binding
C380_RS17515	COG2081	HI0933 family
C380_RS17525	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C380_RS17535	COG0583	DNA-binding transcription factor activity
C380_RS17540	COG0473	3-isopropylmalate dehydrogenase activity
C380_RS17570	COG0702	epimerase
C380_RS17575	COG0312	modulator of DNA gyrase
C380_RS17580	COG3028	Belongs to the UPF0307 family
C380_RS17585	COG0521	Mo-molybdopterin cofactor biosynthetic process
C380_RS17595	COG1045	serine acetyltransferase
C380_RS17605	COG0483	inositol monophosphate 1-phosphatase activity
C380_RS17625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C380_RS17680	COG1968	undecaprenyl-diphosphatase activity
C380_RS17710	COG3275	phosphorelay sensor kinase activity
C380_RS17725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C380_RS17740	COG1280	lysine exporter protein (LysE YggA)
C380_RS17745	COG4133	protoheme IX ABC transporter activity
C380_RS17755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C380_RS17760	COG0385	Bile acid
C380_RS17765	COG2072	flavoprotein involved in K transport
C380_RS17770	COG0300	oxidoreductase activity
C380_RS17775	COG1414	Transcriptional regulator
C380_RS17785	COG1234	tRNA 3'-trailer cleavage
C380_RS17795	COG2205	protein histidine kinase activity
C380_RS17795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C380_RS17810	COG0745	RESPONSE REGULATOR receiver
C380_RS17815	COG0745	RESPONSE REGULATOR receiver
C380_RS17835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C380_RS17840	COG3608	succinylglutamate desuccinylase aspartoacylase
C380_RS17840	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C380_RS17890	COG0655	NAD(P)H dehydrogenase (quinone) activity
C380_RS17900	COG0798	PFAM Bile acid sodium symporter
C380_RS17915	COG0640	Transcriptional regulator
C380_RS17920	COG2200	EAL domain
C380_RS17920	COG2199	diguanylate cyclase activity
C380_RS17920	COG2202	Pas domain
C380_RS17960	COG1126	abc transporter atp-binding protein
C380_RS17980	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C380_RS17985	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C380_RS17990	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C380_RS17995	COG0142	geranyltranstransferase activity
C380_RS18000	COG1722	exodeoxyribonuclease VII activity
C380_RS18055	COG2369	cell adhesion
C380_RS18060	COG4383	Mu-like prophage protein gp29
C380_RS18065	COG4373	Mu-like prophage FluMu protein gp28
C380_RS18095	COG3772	lysozyme
C380_RS18150	COG3409	Peptidoglycan-binding domain 1 protein
C380_RS18150	COG3267	Type II secretory pathway component ExeA
C380_RS18190	COG2974	May be involved in recombination
C380_RS18215	COG4388	Caudovirus prohead serine protease
C380_RS18225	COG4397	Mu-like prophage major head subunit gpT
C380_RS18290	COG0628	permease
C380_RS18300	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C380_RS18305	COG0181	hydroxymethylbilane synthase activity
C380_RS18325	COG3038	cytochrome b561
C380_RS18330	COG2353	YceI-like domain
C380_RS18345	COG0501	Belongs to the peptidase M48B family
C380_RS18350	COG0525	valine-tRNA ligase activity
C380_RS18355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C380_RS18360	COG0425	Belongs to the sulfur carrier protein TusA family
C380_RS18390	COG0583	DNA-binding transcription factor activity
C380_RS18395	COG1960	acyl-CoA dehydrogenase activity
C380_RS18400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C380_RS18425	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C380_RS18430	COG0129	dihydroxy-acid dehydratase activity
C380_RS18440	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C380_RS18445	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C380_RS18450	COG2910	NAD(P)H-binding
C380_RS18455	COG0583	DNA-binding transcription factor activity
C380_RS18465	COG0835	chemotaxis
C380_RS18465	COG0784	Response regulator, receiver
C380_RS18495	COG4566	intracellular signal transduction
C380_RS18510	COG0617	tRNA 3'-terminal CCA addition
C380_RS18520	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C380_RS18530	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C380_RS18555	COG4977	sequence-specific DNA binding
C380_RS18555	COG1917	Cupin 2, conserved barrel domain protein
C380_RS18590	COG0728	peptidoglycan biosynthetic process
C380_RS18595	COG0268	Binds directly to 16S ribosomal RNA
C380_RS18610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C380_RS18615	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C380_RS18675	COG0727	PFAM Uncharacterised protein family (UPF0153)
C380_RS18680	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C380_RS18690	COG3483	tryptophan 2,3-dioxygenase activity
C380_RS18715	COG2719	SpoVR family
C380_RS18720	COG2718	Belongs to the UPF0229 family
C380_RS18725	COG2766	serine protein kinase
C380_RS18730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C380_RS18745	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C380_RS18760	COG2916	Histone family protein nucleoid-structuring protein H-NS
C380_RS18765	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C380_RS18770	COG0513	Belongs to the DEAD box helicase family
C380_RS18775	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C380_RS18790	COG0724	RNA recognition motif
C380_RS18795	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C380_RS18815	COG0437	4 iron, 4 sulfur cluster binding
C380_RS18820	COG3383	formate dehydrogenase (NAD+) activity
C380_RS18820	COG0243	molybdopterin cofactor binding
C380_RS18850	COG3383	formate dehydrogenase (NAD+) activity
C380_RS18865	COG0489	protein tyrosine kinase activity
C380_RS18885	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C380_RS18885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C380_RS18915	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C380_RS18920	COG0602	queuosine metabolic process
C380_RS18925	COG0720	synthase
C380_RS18930	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C380_RS18940	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C380_RS18945	COG0156	8-amino-7-oxononanoate synthase activity
C380_RS18955	COG1028	Short-chain dehydrogenase reductase Sdr
C380_RS18975	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C380_RS18985	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C380_RS18990	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C380_RS19005	COG2307	Protein conserved in bacteria
C380_RS19005	COG2308	Evidence 4 Homologs of previously reported genes of
C380_RS19010	COG1305	Transglutaminase-like
C380_RS19020	COG2308	Evidence 4 Homologs of previously reported genes of
C380_RS19050	COG2197	response regulator
C380_RS19060	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C380_RS19065	COG0793	Belongs to the peptidase S41A family
C380_RS19070	COG0588	phosphoglycerate mutase activity
C380_RS19075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C380_RS19085	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C380_RS19090	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C380_RS19100	COG0583	DNA-binding transcription factor activity
C380_RS19105	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C380_RS19110	COG0742	ribosomal rna small subunit methyltransferase
C380_RS19115	COG0612	Peptidase, M16
C380_RS19120	COG0612	Peptidase, M16
C380_RS19140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C380_RS19145	COG3181	Tripartite tricarboxylate transporter family receptor
C380_RS19150	COG1999	signal sequence binding
C380_RS19155	COG0109	protoheme IX farnesyltransferase activity
C380_RS19180	COG1845	cytochrome c oxidase, subunit III
C380_RS19190	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C380_RS19195	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C380_RS19210	COG2226	methyltransferase
C380_RS19215	COG1040	competence protein
C380_RS19220	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C380_RS19225	COG0583	DNA-binding transcription factor activity
C380_RS19240	COG1280	lysine exporter protein (LysE YggA)
C380_RS19245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C380_RS19245	COG0475	glutathione-regulated potassium exporter activity
C380_RS19250	COG2860	membrane
C380_RS19265	COG0583	DNA-binding transcription factor activity
C380_RS19280	COG1028	Short-chain dehydrogenase reductase Sdr
C380_RS19285	COG0183	Belongs to the thiolase family
C380_RS19290	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C380_RS19300	COG1414	Transcriptional regulator
C380_RS19330	COG0411	ABC transporter
C380_RS19345	COG0066	3-isopropylmalate dehydratase activity
C380_RS19350	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C380_RS19415	COG5006	permease, DMT superfamily
C380_RS19420	COG1522	sequence-specific DNA binding
C380_RS19425	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C380_RS19440	COG1840	ABC-type Fe3 transport system, periplasmic component
C380_RS19445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C380_RS19465	COG2721	sulfolactate sulfo-lyase activity
C380_RS19470	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C380_RS19470	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C380_RS19480	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C380_RS19490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C380_RS19495	COG2188	Transcriptional regulator
C380_RS19500	COG1012	belongs to the aldehyde dehydrogenase family
C380_RS19510	COG4773	Receptor
C380_RS19520	COG0784	Response regulator, receiver
C380_RS19520	COG5002	protein histidine kinase activity
C380_RS19520	COG2205	protein histidine kinase activity
C380_RS19525	COG1178	ABC-type Fe3 transport system permease component
C380_RS19530	COG3842	ATPase activity
C380_RS19570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C380_RS19575	COG0540	Belongs to the ATCase OTCase family
C380_RS19580	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C380_RS19585	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C380_RS19590	COG1678	Uncharacterized ACR, COG1678
C380_RS19595	COG0415	Belongs to the DNA photolyase family
C380_RS19605	COG0784	Response regulator, receiver
C380_RS19605	COG2198	Histidine kinase
C380_RS19605	COG0643	Histidine kinase
C380_RS19610	COG0840	transmembrane signaling receptor activity
C380_RS19615	COG0835	chemotaxis
C380_RS19635	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C380_RS19640	COG1414	Transcriptional regulator
C380_RS19645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C380_RS19650	COG4654	Cytochrome c, class I
C380_RS19655	COG0138	bifunctional purine biosynthesis protein purh
C380_RS19660	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C380_RS19665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C380_RS19675	COG1238	metal cluster binding
C380_RS19690	COG0012	GTP binding
C380_RS19695	COG0633	Ferredoxin
C380_RS19695	COG3217	Mosc domain protein beta barrel domain protein
C380_RS19700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C380_RS19715	COG1024	Enoyl-CoA hydratase
C380_RS19730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C380_RS19735	COG2205	protein histidine kinase activity
C380_RS19745	COG2204	response regulator
C380_RS19750	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C380_RS19755	COG2943	transferase activity, transferring hexosyl groups
C380_RS19760	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C380_RS19765	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C380_RS19795	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C380_RS19805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C380_RS19815	COG2264	protein methyltransferase activity
C380_RS19820	COG0439	Biotin carboxylase
C380_RS19825	COG0511	ligase activity, forming carbon-carbon bonds
C380_RS19830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C380_RS19840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C380_RS19850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C380_RS19860	COG0312	modulator of DNA gyrase
C380_RS19870	COG0772	Belongs to the SEDS family
C380_RS19875	COG0515	serine threonine protein kinase
C380_RS19875	COG2815	serine threonine protein kinase
C380_RS19880	COG3150	esterase
C380_RS19890	COG0557	exoribonuclease II activity
C380_RS19900	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C380_RS19905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C380_RS19925	COG0575	Belongs to the CDS family
C380_RS19930	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C380_RS19945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C380_RS19980	COG1132	(ABC) transporter
C380_RS19985	COG0189	ligase activity
C380_RS19985	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C380_RS19990	COG0189	ligase activity
C380_RS19990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C380_RS19995	COG3045	CreA protein
C380_RS20000	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C380_RS20005	COG1028	Short-chain dehydrogenase reductase Sdr
C380_RS20020	COG3829	transcription factor binding
C380_RS20020	COG3290	protein histidine kinase activity
C380_RS20025	COG0318	PFAM AMP-dependent synthetase and ligase
C380_RS20030	COG0183	Belongs to the thiolase family
C380_RS20060	COG1272	protein, Hemolysin III
C380_RS20070	COG0318	PFAM AMP-dependent synthetase and ligase
C380_RS20075	COG1250	3-hydroxyacyl-CoA dehydrogenase
C380_RS20085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C380_RS20155	COG0583	DNA-binding transcription factor activity
C380_RS20160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C380_RS20165	COG3002	Belongs to the UPF0753 family
C380_RS20180	COG0596	Alpha beta hydrolase
C380_RS20190	COG1522	sequence-specific DNA binding
C380_RS20195	COG3706	GGDEF domain
C380_RS20200	COG2205	protein histidine kinase activity
C380_RS20205	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C380_RS20220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C380_RS20240	COG0583	DNA-binding transcription factor activity
C380_RS20245	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C380_RS20250	COG0739	heme binding
C380_RS20255	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C380_RS20260	COG2814	Major facilitator Superfamily
C380_RS20265	COG0316	Belongs to the HesB IscA family
C380_RS20280	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C380_RS20285	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C380_RS20295	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C380_RS20300	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C380_RS20315	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C380_RS20320	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C380_RS20340	COG4154	Belongs to the RbsD FucU family
C380_RS20375	COG1522	sequence-specific DNA binding
C380_RS20390	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C380_RS20395	COG0683	leucine binding
C380_RS20400	COG0683	leucine binding
C380_RS20450	COG0583	DNA-binding transcription factor activity
C380_RS20455	COG1250	3-hydroxyacyl-CoA dehydrogenase
C380_RS20460	COG3246	L-lysine catabolic process to acetate
C380_RS20465	COG3181	Tripartite tricarboxylate transporter family receptor
C380_RS20470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C380_RS20485	COG1024	Enoyl-CoA hydratase
C380_RS20490	COG2318	DinB family
C380_RS20495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C380_RS20500	COG0318	PFAM AMP-dependent synthetase and ligase
C380_RS20525	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C380_RS20540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C380_RS20545	COG3012	SEC-C Motif Domain Protein
C380_RS20590	COG1960	acyl-CoA dehydrogenase activity
C380_RS20605	COG0183	Belongs to the thiolase family
C380_RS20610	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C380_RS20615	COG0288	reversible hydration of carbon dioxide
C380_RS20620	COG1960	acyl-CoA dehydrogenase activity
C380_RS20665	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C380_RS20665	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C380_RS20670	COG0488	(ABC) transporter
C380_RS20675	COG2201	protein-glutamate methylesterase activity
C380_RS20680	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C380_RS20685	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C380_RS20690	COG0835	chemotaxis
C380_RS20695	COG2198	Histidine kinase
C380_RS20695	COG0643	Histidine kinase
C380_RS20700	COG0835	chemotaxis
C380_RS20700	COG0784	Response regulator, receiver
C380_RS20715	COG2197	response regulator
C380_RS20725	COG1987	bacterial-type flagellum assembly
C380_RS20740	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C380_RS20750	COG1580	Controls the rotational direction of flagella during chemotaxis
C380_RS20785	COG1677	Flagellar hook-basal body complex protein FliE
C380_RS20805	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C380_RS20825	COG1360	Flagellar Motor Protein
C380_RS20830	COG0745	RESPONSE REGULATOR receiver
C380_RS20835	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C380_RS20840	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C380_RS20845	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C380_RS20860	COG1191	sigma factor activity
C380_RS20885	COG1558	bacterial-type flagellum-dependent cell motility
C380_RS20890	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C380_RS20900	COG4787	bacterial-type flagellum-dependent cell motility
C380_RS20910	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C380_RS20915	COG1706	bacterial-type flagellum-dependent cell motility
C380_RS20930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C380_RS20940	COG0436	Aminotransferase
C380_RS20950	COG0697	spore germination
C380_RS20960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C380_RS20965	COG0625	glutathione transferase activity
C380_RS20975	COG0384	phenazine biosynthesis protein PhzF
C380_RS20985	COG1280	lysine exporter protein (LysE YggA)
C380_RS21010	COG0318	PFAM AMP-dependent synthetase and ligase
C380_RS21020	COG1129	ABC transporter
C380_RS21025	COG1172	Belongs to the binding-protein-dependent transport system permease family
C380_RS21035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C380_RS21040	COG1869	D-ribose catabolic process
C380_RS21060	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C380_RS21065	COG0625	glutathione transferase activity
C380_RS21080	COG0617	tRNA 3'-terminal CCA addition
C380_RS21090	COG4944	Protein of unknown function (DUF1109)
C380_RS21095	COG1595	DNA-templated transcription, initiation
C380_RS21105	COG3220	belongs to the UPF0276 family
C380_RS21125	COG1877	trehalose-phosphatase activity
C380_RS21130	COG3387	PFAM Glycoside hydrolase 15-related
C380_RS21160	COG1012	belongs to the aldehyde dehydrogenase family
C380_RS21165	COG1028	Short-chain dehydrogenase reductase Sdr
C380_RS21170	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C380_RS21180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C380_RS21205	COG1024	Enoyl-CoA hydratase
C380_RS21205	COG1250	3-hydroxyacyl-CoA dehydrogenase
C380_RS21210	COG0163	prenyltransferase activity
C380_RS21245	COG0583	DNA-binding transcription factor activity
C380_RS21255	COG0037	tRNA processing
C380_RS21280	COG2255	four-way junction helicase activity
C380_RS21295	COG0632	four-way junction helicase activity
C380_RS21300	COG1702	phosphate starvation-inducible protein PhoH
C380_RS21305	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C380_RS21310	COG0730	response to heat
C380_RS21320	COG0589	response to stress
C380_RS21325	COG1490	D-aminoacyl-tRNA deacylase activity
C380_RS21330	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C380_RS21335	COG4191	Histidine kinase
C380_RS21350	COG0666	response to abiotic stimulus
C380_RS21370	COG3181	Tripartite tricarboxylate transporter family receptor
C380_RS21375	COG2267	carboxylic ester hydrolase activity
C380_RS21385	COG0183	Belongs to the thiolase family
C380_RS21395	COG0513	Belongs to the DEAD box helicase family
C380_RS21410	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C380_RS21440	COG4232	protein-disulfide reductase activity
C380_RS21445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C380_RS21450	COG1832	CoA-binding protein
C380_RS21460	COG1414	Transcriptional regulator
C380_RS21470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C380_RS21490	COG0861	Integral membrane protein TerC family
C380_RS21495	COG0583	DNA-binding transcription factor activity
C380_RS21500	COG3119	arylsulfatase activity
C380_RS21515	COG2814	Major facilitator Superfamily
C380_RS21520	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C380_RS21530	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C380_RS21535	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C380_RS21540	COG0405	Gamma-glutamyltransferase
C380_RS21550	COG0679	Auxin Efflux Carrier
C380_RS21560	COG0210	DNA helicase
C380_RS21585	COG0343	queuine tRNA-ribosyltransferase activity
C380_RS21640	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C380_RS21645	COG3181	Tripartite tricarboxylate transporter family receptor
C380_RS21650	COG0318	PFAM AMP-dependent synthetase and ligase
C380_RS21650	COG0204	Acyl-transferase
C380_RS21665	COG1309	transcriptional regulator
C380_RS21675	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C380_RS21700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C380_RS21720	COG1253	flavin adenine dinucleotide binding
C380_RS21735	COG2847	Copper chaperone PCu(A)C
C380_RS21755	COG0625	glutathione transferase activity
C380_RS21775	COG2095	MarC family integral membrane protein
C380_RS21785	COG0583	DNA-binding transcription factor activity
C380_RS21795	COG0203	ribosomal protein L17
C380_RS21800	COG0202	RNA polymerase activity
C380_RS21805	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C380_RS21810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C380_RS21815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C380_RS21820	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C380_RS21825	COG0201	protein transport
C380_RS21830	COG0200	Binds to the 23S rRNA
C380_RS21835	COG1841	ribosomal large subunit assembly
C380_RS21840	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C380_RS21845	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C380_RS21850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C380_RS21855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C380_RS21860	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C380_RS21865	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C380_RS21870	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C380_RS21875	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C380_RS21880	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C380_RS21895	COG0395	ABC-type sugar transport system, permease component
C380_RS21910	COG3842	ATPase activity
C380_RS21920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C380_RS21930	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C380_RS21940	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C380_RS21950	COG5002	protein histidine kinase activity
C380_RS21955	COG0745	RESPONSE REGULATOR receiver
C380_RS21960	COG0783	Belongs to the Dps family
C380_RS21975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C380_RS21990	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C380_RS22010	COG0583	DNA-binding transcription factor activity
C380_RS22020	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C380_RS22025	COG0134	indole-3-glycerol-phosphate synthase activity
C380_RS22030	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C380_RS22035	COG1280	lysine exporter protein (LysE YggA)
C380_RS22040	COG0512	Glutamine amidotransferase of anthranilate synthase
C380_RS22065	COG0546	phosphoglycolate phosphatase activity
C380_RS22095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C380_RS22100	COG2967	ApaG domain
C380_RS22115	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C380_RS22130	COG1595	DNA-templated transcription, initiation
C380_RS22160	COG0589	response to stress
C380_RS22165	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C380_RS22170	COG1546	Belongs to the CinA family
C380_RS22175	COG0596	Alpha beta hydrolase
C380_RS22190	COG0653	protein targeting
C380_RS22195	COG0069	glutamate synthase activity
C380_RS22230	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C380_RS22235	COG1137	ATPase activity
C380_RS22245	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C380_RS22255	COG0018	arginyl-trna synthetase
C380_RS22275	COG1301	dicarboxylic acid transport
C380_RS22280	COG4191	Histidine kinase
C380_RS22305	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C380_RS22310	COG1942	4-Oxalocrotonate Tautomerase
C380_RS22315	COG2814	Major facilitator Superfamily
C380_RS22320	COG0121	glutamine amidotransferase
C380_RS22350	COG0189	ligase activity
C380_RS22355	COG3135	benzoate transporter
C380_RS22360	COG3158	transport of potassium into the cell
C380_RS22370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C380_RS22375	COG0569	domain protein
C380_RS22380	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C380_RS22400	COG0010	Belongs to the arginase family
C380_RS22410	COG0495	leucyl-tRNA aminoacylation
C380_RS22425	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C380_RS22430	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C380_RS22435	COG0735	belongs to the Fur family
C380_RS22440	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C380_RS22450	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C380_RS22460	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C380_RS22465	COG3118	belongs to the thioredoxin family
C380_RS22470	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C380_RS22475	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C380_RS22480	COG0009	L-threonylcarbamoyladenylate synthase
C380_RS22515	COG4095	Psort location CytoplasmicMembrane, score
C380_RS22530	COG1214	PFAM Peptidase M22, glycoprotease
C380_RS22550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C380_RS22555	COG0318	PFAM AMP-dependent synthetase and ligase
C380_RS22560	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C380_RS22565	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C380_RS22580	COG0642	Histidine kinase
C380_RS22595	COG0671	phosphoesterase, PA-phosphatase related
C380_RS22600	COG0469	pyruvate kinase activity
C380_RS22610	COG0006	proline dipeptidase activity
C380_RS22620	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C380_RS22625	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C380_RS22630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C380_RS22635	COG0668	transmembrane transport
C380_RS22650	COG0667	Aldo Keto reductase
C380_RS22665	COG0740	serine-type endopeptidase activity
C380_RS22700	COG2159	amidohydrolase
C380_RS22710	COG0583	DNA-binding transcription factor activity
C380_RS22770	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C380_RS22805	COG0625	glutathione transferase activity
C380_RS22845	COG2764	glyoxalase bleomycin resistance protein dioxygenase
C380_RS22855	COG2378	regulation of single-species biofilm formation
C380_RS22870	COG1028	Short-chain dehydrogenase reductase Sdr
C380_RS22875	COG0583	DNA-binding transcription factor activity
C380_RS22880	COG1028	Short-chain dehydrogenase reductase Sdr
C380_RS22915	COG3284	Transcriptional regulator
C380_RS22920	COG1012	belongs to the aldehyde dehydrogenase family
C380_RS22930	COG0840	transmembrane signaling receptor activity
C380_RS22955	COG0583	DNA-binding transcription factor activity
C380_RS22960	COG0284	orotidine-5'-phosphate decarboxylase activity
C380_RS22965	COG0126	phosphoglycerate kinase activity
C380_RS22980	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C380_RS22990	COG0242	peptide deformylase activity
C380_RS23000	COG0758	DNA mediated transformation
C380_RS23010	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C380_RS23015	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C380_RS23020	COG1862	Preprotein translocase
C380_RS23030	COG1522	sequence-specific DNA binding
C380_RS23065	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C380_RS23080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C380_RS23110	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C380_RS23140	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C380_RS23140	COG1082	Xylose isomerase domain protein TIM barrel
C380_RS23150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C380_RS23155	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C380_RS23160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C380_RS23165	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C380_RS23170	COG1309	transcriptional regulator
C380_RS23175	COG0625	glutathione transferase activity
C380_RS23200	COG0861	Integral membrane protein TerC family
C380_RS23210	COG1950	PFAM Membrane protein of
C380_RS23215	COG4783	chaperone-mediated protein folding
C380_RS23220	COG0315	cyclic pyranopterin monophosphate synthase activity
C380_RS23245	COG1716	ATPase activity
C380_RS23255	COG0515	serine threonine protein kinase
C380_RS23255	COG2815	serine threonine protein kinase
C380_RS23260	COG0861	Integral membrane protein TerC family
C380_RS23265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C380_RS23270	COG0045	succinate-CoA ligase (ADP-forming) activity
C380_RS23275	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C380_RS23280	COG2137	regulation of response to DNA damage stimulus
C380_RS23285	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C380_RS23315	COG0642	Histidine kinase
C380_RS23345	COG0551	DNA topoisomerase type I activity
C380_RS23345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C380_RS23370	COG2365	Tyrosine phosphatase family
C380_RS23375	COG2814	Major facilitator Superfamily
C380_RS23380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C380_RS23400	COG3148	PFAM DTW domain containing protein
C380_RS23425	COG2814	Major facilitator Superfamily
C380_RS23430	COG0629	single-stranded DNA binding
C380_RS23445	COG0482	sulfurtransferase activity
C380_RS23450	COG0583	DNA-binding transcription factor activity
C380_RS23455	COG2828	Protein conserved in bacteria
C380_RS23465	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C380_RS23470	COG1620	l-lactate permease
C380_RS23500	COG0583	DNA-binding transcription factor activity
C380_RS23510	COG1012	belongs to the aldehyde dehydrogenase family
C380_RS23515	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C380_RS23560	COG2198	Histidine kinase
C380_RS23560	COG2205	protein histidine kinase activity
C380_RS23560	COG0784	Response regulator, receiver
C380_RS23565	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C380_RS23590	COG4786	Flagellar basal body rod
C380_RS23635	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C380_RS23640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C380_RS23645	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C380_RS23655	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C380_RS23690	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C380_RS23705	COG3154	lipid carrier protein
C380_RS23710	COG1272	protein, Hemolysin III
C380_RS23715	COG0826	peptidase U32
C380_RS23720	COG0826	peptidase U32
C380_RS23745	COG2267	carboxylic ester hydrolase activity
C380_RS23760	COG0840	transmembrane signaling receptor activity
C380_RS23765	COG3622	Belongs to the hyi family
C380_RS23775	COG2813	Specifically methylates the guanine in position
C380_RS23775	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C380_RS23780	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C380_RS23785	COG2119	membrane
C380_RS23790	COG0724	RNA recognition motif
C380_RS23795	COG0724	RNA recognition motif
C380_RS23800	COG4221	oxidoreductase activity
C380_RS23810	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C380_RS23815	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C380_RS23815	COG0517	IMP dehydrogenase activity
C380_RS23830	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C380_RS23845	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C380_RS23860	COG0706	membrane insertase activity
C380_RS23865	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C380_RS23870	COG0594	ribonuclease P activity
C380_RS23875	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C380_RS23890	COG1199	ATP-dependent helicase activity
C380_RS23930	COG5002	protein histidine kinase activity
C380_RS24090	COG1396	sequence-specific DNA binding
C380_RS24135	COG0642	Histidine kinase