locus-tag	class	description
H2785_RS00010	COG0592	DNA-directed DNA polymerase activity
H2785_RS00020	COG0187	DNA topoisomerase II activity
H2785_RS00030	COG0586	Pfam SNARE associated Golgi protein
H2785_RS00035	COG0488	(ABC) transporter
H2785_RS00060	COG0596	Alpha beta hydrolase
H2785_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H2785_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H2785_RS00110	COG0733	neurotransmitter:sodium symporter activity
H2785_RS00120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H2785_RS00145	COG0583	DNA-binding transcription factor activity
H2785_RS00150	COG2233	PERMEase
H2785_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2785_RS00200	COG2814	Major facilitator Superfamily
H2785_RS00205	COG0656	L-ascorbic acid biosynthetic process
H2785_RS00210	COG0583	DNA-binding transcription factor activity
H2785_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2785_RS00230	COG1064	alcohol dehydrogenase
H2785_RS00235	COG2818	Glycosylase
H2785_RS00250	COG1194	a g-specific adenine glycosylase
H2785_RS00270	COG2983	Belongs to the UPF0260 family
H2785_RS00275	COG2133	pyrroloquinoline quinone binding
H2785_RS00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H2785_RS00285	COG2116	formate transmembrane transporter activity
H2785_RS00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2785_RS00310	COG1335	isochorismatase
H2785_RS00315	COG0385	Bile acid
H2785_RS00320	COG0534	Mate efflux family protein
H2785_RS00325	COG1683	Conserved Protein
H2785_RS00345	COG0625	glutathione transferase activity
H2785_RS00355	COG1113	amino acid transport
H2785_RS00365	COG0523	cobalamin synthesis protein
H2785_RS00375	COG2188	Transcriptional regulator
H2785_RS00405	COG0010	Belongs to the arginase family
H2785_RS00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H2785_RS00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H2785_RS00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H2785_RS00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H2785_RS00525	COG0534	Mate efflux family protein
H2785_RS00530	COG0436	Aminotransferase
H2785_RS00535	COG2733	membrane
H2785_RS00550	COG2918	glutathione biosynthetic process
H2785_RS00565	COG3179	chitinase
H2785_RS00580	COG3150	esterase
H2785_RS00590	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H2785_RS00600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2785_RS00610	COG2233	PERMEase
H2785_RS00615	COG2351	hydroxyisourate hydrolase activity
H2785_RS00650	COG3706	GGDEF domain
H2785_RS00665	COG1393	Belongs to the ArsC family
H2785_RS00670	COG0708	Exodeoxyribonuclease III
H2785_RS00690	COG0189	ligase activity
H2785_RS00710	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H2785_RS00720	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H2785_RS00735	COG4942	peptidase
H2785_RS00745	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2785_RS00755	COG2119	membrane
H2785_RS00760	COG4774	siderophore transport
H2785_RS00765	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2785_RS00765	COG0426	domain, Protein
H2785_RS00790	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H2785_RS00815	COG1902	pentaerythritol trinitrate reductase activity
H2785_RS00820	COG1519	Transferase
H2785_RS00825	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H2785_RS00830	COG0668	transmembrane transport
H2785_RS00840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H2785_RS00845	COG1335	isochorismatase
H2785_RS00850	COG1522	sequence-specific DNA binding
H2785_RS00875	COG2205	protein histidine kinase activity
H2785_RS00875	COG2198	Histidine kinase
H2785_RS00875	COG0784	Response regulator, receiver
H2785_RS00880	COG3162	membrane
H2785_RS00885	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H2785_RS00895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H2785_RS00910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H2785_RS00915	COG1309	transcriptional regulator
H2785_RS00935	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H2785_RS00935	COG0352	thiamine-phosphate diphosphorylase activity
H2785_RS00935	COG0351	phosphomethylpyrimidine kinase
H2785_RS00945	COG2814	Major facilitator Superfamily
H2785_RS00985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H2785_RS00995	COG1113	amino acid transport
H2785_RS01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H2785_RS01010	COG1012	belongs to the aldehyde dehydrogenase family
H2785_RS01020	COG1335	isochorismatase
H2785_RS01050	COG2814	Major facilitator Superfamily
H2785_RS01055	COG0583	DNA-binding transcription factor activity
H2785_RS01075	COG0667	Aldo Keto reductase
H2785_RS01090	COG3081	Nucleoid-associated protein
H2785_RS01105	COG1733	regulation of RNA biosynthetic process
H2785_RS01110	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2785_RS01180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H2785_RS01205	COG1132	(ABC) transporter
H2785_RS01225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H2785_RS01255	COG0427	acetyl-CoA hydrolase
H2785_RS01280	COG0659	secondary active sulfate transmembrane transporter activity
H2785_RS01285	COG4221	oxidoreductase activity
H2785_RS01295	COG0488	(ABC) transporter
H2785_RS01360	COG0833	amino acid
H2785_RS01405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H2785_RS01410	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H2785_RS01425	COG2226	methyltransferase
H2785_RS01475	COG0067	glutamate synthase
H2785_RS01475	COG0069	glutamate synthase activity
H2785_RS01475	COG0070	glutamate synthase
H2785_RS01480	COG0493	'glutamate synthase
H2785_RS01490	COG1704	LemA family
H2785_RS01495	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H2785_RS01515	COG3307	-O-antigen
H2785_RS01535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H2785_RS01550	COG0194	GDP metabolic process
H2785_RS01600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H2785_RS01620	COG5380	lipid catabolic process
H2785_RS01625	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H2785_RS01650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H2785_RS01655	COG0277	FAD linked oxidase domain protein
H2785_RS01665	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H2785_RS01670	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2785_RS01685	COG1289	transmembrane transporter activity
H2785_RS01695	COG0628	permease
H2785_RS01700	COG1192	Involved in chromosome partitioning
H2785_RS01730	COG0833	amino acid
H2785_RS01735	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H2785_RS01740	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H2785_RS01750	COG1012	belongs to the aldehyde dehydrogenase family
H2785_RS01790	COG0583	DNA-binding transcription factor activity
H2785_RS01840	COG0517	IMP dehydrogenase activity
H2785_RS01845	COG1983	PspC domain protein
H2785_RS01855	COG1960	acyl-CoA dehydrogenase activity
H2785_RS01870	COG0408	coproporphyrinogen oxidase activity
H2785_RS01890	COG0513	Belongs to the DEAD box helicase family
H2785_RS01900	COG1127	ABC transporter
H2785_RS01905	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H2785_RS01915	COG2854	intermembrane phospholipid transfer
H2785_RS01925	COG0598	Magnesium transport protein CorA
H2785_RS01935	COG0494	nUDIX hydrolase
H2785_RS01940	COG1040	competence protein
H2785_RS01945	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H2785_RS01960	COG2937	Belongs to the GPAT DAPAT family
H2785_RS01965	COG1946	Acyl-CoA thioesterase
H2785_RS01970	COG1301	dicarboxylic acid transport
H2785_RS01985	COG1959	2 iron, 2 sulfur cluster binding
H2785_RS01990	COG1017	nitric oxide dioxygenase activity
H2785_RS01990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2785_RS02000	COG0433	COG0433 Predicted ATPase
H2785_RS02005	COG0626	cystathionine gamma-synthase activity
H2785_RS02160	COG1960	acyl-CoA dehydrogenase activity
H2785_RS02165	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H2785_RS02195	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H2785_RS02200	COG0339	signal peptide processing
H2785_RS02205	COG0557	exoribonuclease II activity
H2785_RS02250	COG0179	Fumarylacetoacetate (FAA) hydrolase
H2785_RS02255	COG2169	Transcriptional regulator
H2785_RS02260	COG0697	spore germination
H2785_RS02265	COG1295	ribonuclease BN
H2785_RS02300	COG1702	phosphate starvation-inducible protein PhoH
H2785_RS02310	COG0739	heme binding
H2785_RS02310	COG0741	lytic transglycosylase activity
H2785_RS02310	COG1196	nuclear chromosome segregation
H2785_RS02340	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H2785_RS02345	COG1183	phosphatidylcholine synthase activity
H2785_RS02390	COG1960	acyl-CoA dehydrogenase activity
H2785_RS02395	COG1309	transcriptional regulator
H2785_RS02410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H2785_RS02415	COG1960	acyl-CoA dehydrogenase activity
H2785_RS02435	COG2969	positive regulation of protein catabolic process
H2785_RS02445	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H2785_RS02455	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H2785_RS02460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H2785_RS02465	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H2785_RS02485	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H2785_RS02495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H2785_RS02500	COG1408	metallophosphoesterase
H2785_RS02510	COG2199	diguanylate cyclase activity
H2785_RS02570	COG1607	acyl-coa hydrolase
H2785_RS02600	COG2350	Protein conserved in bacteria
H2785_RS02610	COG0613	PHP domain protein
H2785_RS02615	COG3781	membrane
H2785_RS02625	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H2785_RS02630	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H2785_RS02640	COG1862	Preprotein translocase
H2785_RS02670	COG2205	protein histidine kinase activity
H2785_RS02675	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H2785_RS02695	COG0726	polysaccharide deacetylase
H2785_RS02700	COG0463	Glycosyl transferase, family 2
H2785_RS02705	COG0438	transferase activity, transferring glycosyl groups
H2785_RS02770	COG1960	acyl-CoA dehydrogenase activity
H2785_RS02775	COG1960	acyl-CoA dehydrogenase activity
H2785_RS02785	COG2205	protein histidine kinase activity
H2785_RS02790	COG0745	RESPONSE REGULATOR receiver
H2785_RS02795	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H2785_RS02815	COG2096	Adenosyltransferase
H2785_RS02865	COG0285	dihydrofolate synthase activity
H2785_RS02885	COG0450	alkyl hydroperoxide reductase
H2785_RS02900	COG0477	Major facilitator Superfamily
H2785_RS02905	COG1272	protein, Hemolysin III
H2785_RS02915	COG2153	protein acetylation
H2785_RS02935	COG0183	Belongs to the thiolase family
H2785_RS02940	COG2207	Transcriptional regulator
H2785_RS02960	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2785_RS02980	COG0183	Belongs to the thiolase family
H2785_RS02990	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H2785_RS02990	COG2885	chlorophyll binding
H2785_RS03000	COG1690	Belongs to the RtcB family
H2785_RS03005	COG0833	amino acid
H2785_RS03015	COG2233	PERMEase
H2785_RS03020	COG1217	gtp-binding protein TYPA
H2785_RS03045	COG2094	Belongs to the DNA glycosylase MPG family
H2785_RS03050	COG4772	TonB-dependent receptor
H2785_RS03055	COG1902	pentaerythritol trinitrate reductase activity
H2785_RS03070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H2785_RS03075	COG0354	folic acid binding
H2785_RS03085	COG3189	MarR family transcriptional regulator
H2785_RS03090	COG2824	Alkylphosphonate utilization operon protein PhnA
H2785_RS03095	COG3422	double-strand break repair
H2785_RS03135	COG0840	transmembrane signaling receptor activity
H2785_RS03155	COG5510	response to toxic substance
H2785_RS03165	COG2832	Protein of unknown function (DUF454)
H2785_RS03170	COG1376	ErfK ybiS ycfS ynhG family protein
H2785_RS03210	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H2785_RS03220	COG1289	transmembrane transporter activity
H2785_RS03225	COG2814	Major facilitator Superfamily
H2785_RS03245	COG1115	amino acid carrier protein
H2785_RS03250	COG1752	Esterase of the alpha-beta hydrolase superfamily
H2785_RS03255	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H2785_RS03260	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H2785_RS03285	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H2785_RS03295	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H2785_RS03300	COG1077	Cell shape determining protein MreB Mrl
H2785_RS03305	COG1792	Involved in formation and maintenance of cell shape
H2785_RS03310	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H2785_RS03315	COG0424	maF-like protein
H2785_RS03320	COG1530	ribonuclease E activity
H2785_RS03330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2785_RS03340	COG0560	Phosphoserine phosphatase
H2785_RS03350	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2785_RS03375	COG2207	Transcriptional regulator
H2785_RS03420	COG1113	amino acid transport
H2785_RS03425	COG2828	Protein conserved in bacteria
H2785_RS03430	COG0142	geranyltranstransferase activity
H2785_RS03435	COG2315	Protein conserved in bacteria
H2785_RS03450	COG1752	Esterase of the alpha-beta hydrolase superfamily
H2785_RS03470	COG2194	sulfuric ester hydrolase activity
H2785_RS03475	COG0745	RESPONSE REGULATOR receiver
H2785_RS03480	COG0642	Histidine kinase
H2785_RS03490	COG0004	ammonium transporteR
H2785_RS03495	COG0583	DNA-binding transcription factor activity
H2785_RS03515	COG0525	valine-tRNA ligase activity
H2785_RS03525	COG1028	Short-chain dehydrogenase reductase Sdr
H2785_RS03535	COG0393	Putative heavy-metal-binding
H2785_RS03540	COG0393	Putative heavy-metal-binding
H2785_RS03545	COG1538	Outer membrane efflux protein
H2785_RS03555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2785_RS03560	COG0671	phosphoesterase, PA-phosphatase related
H2785_RS03590	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H2785_RS03605	COG1648	precorrin-2 dehydrogenase activity
H2785_RS03605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H2785_RS03610	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H2785_RS03625	COG0531	amino acid
H2785_RS03640	COG0321	lipoyl(octanoyl) transferase activity
H2785_RS03645	COG2921	Belongs to the UPF0250 family
H2785_RS03685	COG2009	succinate dehydrogenase
H2785_RS03690	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H2785_RS03695	COG1053	succinate dehydrogenase
H2785_RS03700	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H2785_RS03725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2785_RS03745	COG2354	Protein conserved in bacteria
H2785_RS03750	COG2321	neutral zinc metallopeptidase
H2785_RS03770	COG2843	Capsule synthesis protein
H2785_RS03785	COG0589	response to stress
H2785_RS03805	COG0505	Belongs to the CarA family
H2785_RS03830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H2785_RS03835	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H2785_RS03885	COG0477	Major facilitator Superfamily
H2785_RS03890	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H2785_RS03905	COG1597	lipid kinase activity
H2785_RS03910	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H2785_RS03935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2785_RS03940	COG0584	glycerophosphoryl diester phosphodiesterase
H2785_RS03960	COG0741	lytic transglycosylase activity
H2785_RS03980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H2785_RS03995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2785_RS04005	COG3811	Belongs to the UPF0386 family
H2785_RS04045	COG0778	Nitroreductase
H2785_RS04060	COG1929	Belongs to the glycerate kinase type-1 family
H2785_RS04065	COG0243	molybdopterin cofactor binding
H2785_RS04070	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H2785_RS04075	COG3339	Conserved Protein
H2785_RS04085	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H2785_RS04100	COG1113	amino acid transport
H2785_RS04110	COG0019	diaminopimelate decarboxylase activity
H2785_RS04120	COG1280	lysine exporter protein (LysE YggA)
H2785_RS04125	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H2785_RS04155	COG0463	Glycosyl transferase, family 2
H2785_RS04175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2785_RS04210	COG4591	ABC-type transport system involved in lipoprotein release permease component
H2785_RS04215	COG1136	(ABC) transporter
H2785_RS04220	COG0658	competence protein
H2785_RS04220	COG2333	competence protein COMEC
H2785_RS04230	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H2785_RS04230	COG0616	signal peptide processing
H2785_RS04235	COG0596	Alpha beta hydrolase
H2785_RS04240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H2785_RS04250	COG0628	permease
H2785_RS04285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H2785_RS04305	COG0823	Involved in the tonB-independent uptake of proteins
H2785_RS04325	COG0824	Thioesterase
H2785_RS04330	COG1473	amidohydrolase
H2785_RS04350	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H2785_RS04350	COG0047	phosphoribosylformylglycinamidine synthase activity
H2785_RS04355	COG2814	Major facilitator Superfamily
H2785_RS04365	COG1024	Enoyl-CoA hydratase
H2785_RS04370	COG1051	belongs to the nudix hydrolase family
H2785_RS04370	COG1056	cytidyltransferase-related domain
H2785_RS04380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H2785_RS04395	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H2785_RS04410	COG4625	pathogenesis
H2785_RS04415	COG0583	DNA-binding transcription factor activity
H2785_RS04420	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H2785_RS04425	COG4208	sulfate ABC transporter
H2785_RS04430	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H2785_RS04440	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H2785_RS04445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H2785_RS04450	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H2785_RS04470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2785_RS04485	COG0681	Belongs to the peptidase S26 family
H2785_RS04500	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H2785_RS04510	COG1381	Involved in DNA repair and RecF pathway recombination
H2785_RS04515	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H2785_RS04525	COG4221	oxidoreductase activity
H2785_RS04555	COG0443	Heat shock 70 kDa protein
H2785_RS04565	COG0436	Aminotransferase
H2785_RS04585	COG0556	nucleotide-excision repair
H2785_RS04640	COG2070	2-Nitropropane dioxygenase
H2785_RS04670	COG1215	transferase activity, transferring glycosyl groups
H2785_RS04685	COG0415	Belongs to the DNA photolyase family
H2785_RS04695	COG1252	NADH dehydrogenase
H2785_RS04700	COG1686	Belongs to the peptidase S11 family
H2785_RS04715	COG1187	pseudouridine synthase activity
H2785_RS04740	COG0477	Major facilitator Superfamily
H2785_RS04745	COG0583	DNA-binding transcription factor activity
H2785_RS04750	COG1823	symporter activity
H2785_RS04760	COG0612	Peptidase, M16
H2785_RS04785	COG0352	thiamine-phosphate diphosphorylase activity
H2785_RS04820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2785_RS04835	COG1309	transcriptional regulator
H2785_RS04845	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H2785_RS04850	COG0076	glutamate decarboxylase activity
H2785_RS04860	COG1522	sequence-specific DNA binding
H2785_RS04865	COG3961	Belongs to the TPP enzyme family
H2785_RS04870	COG1113	amino acid transport
H2785_RS04875	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H2785_RS04880	COG0573	inorganic phosphate transmembrane transporter activity
H2785_RS04890	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H2785_RS04895	COG0616	signal peptide processing
H2785_RS04930	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H2785_RS04935	COG1686	Belongs to the peptidase S11 family
H2785_RS04960	COG0583	DNA-binding transcription factor activity
H2785_RS04965	COG1067	ATP-dependent peptidase activity
H2785_RS04990	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H2785_RS05010	COG1966	Carbon starvation protein
H2785_RS05015	COG2879	small protein
H2785_RS05055	COG1335	isochorismatase
H2785_RS05060	COG0583	DNA-binding transcription factor activity
H2785_RS05075	COG0596	Alpha beta hydrolase
H2785_RS05085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2785_RS05100	COG3659	wide pore channel activity
H2785_RS05125	COG0583	DNA-binding transcription factor activity
H2785_RS05130	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H2785_RS05135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H2785_RS05140	COG2828	Protein conserved in bacteria
H2785_RS05165	COG1741	Belongs to the pirin family
H2785_RS05175	COG2964	Protein conserved in bacteria
H2785_RS05190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2785_RS05195	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2785_RS05200	COG4605	iron ion homeostasis
H2785_RS05205	COG4604	ABC transporter, ATP-binding protein
H2785_RS05210	COG4607	ABC-type enterochelin transport system periplasmic component
H2785_RS05215	COG4774	siderophore transport
H2785_RS05225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2785_RS05230	COG1021	2,3-dihydroxybenzoate-AMP ligase
H2785_RS05235	COG1535	isochorismatase
H2785_RS05235	COG3433	isochorismatase activity
H2785_RS05245	COG1132	(ABC) transporter
H2785_RS05250	COG1132	(ABC) transporter
H2785_RS05255	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H2785_RS05280	COG3739	integral membrane protein
H2785_RS05300	COG0302	gtp cyclohydrolase
H2785_RS05310	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H2785_RS05340	COG0308	aminopeptidase N
H2785_RS05345	COG0512	Glutamine amidotransferase of anthranilate synthase
H2785_RS05360	COG0174	glutamine synthetase
H2785_RS05370	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H2785_RS05405	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H2785_RS05410	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H2785_RS05415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2785_RS05435	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H2785_RS05440	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H2785_RS05445	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H2785_RS05460	COG1960	acyl-CoA dehydrogenase activity
H2785_RS05465	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H2785_RS05470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2785_RS05480	COG2223	nitrite transmembrane transporter activity
H2785_RS05490	COG0024	Methionine aminopeptidase
H2785_RS05495	COG0052	Belongs to the universal ribosomal protein uS2 family
H2785_RS05510	COG2207	Transcriptional regulator
H2785_RS05535	COG2951	lytic endotransglycosylase activity
H2785_RS05540	COG0772	Belongs to the SEDS family
H2785_RS05555	COG0842	Transport permease protein
H2785_RS05560	COG1131	(ABC) transporter
H2785_RS05605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2785_RS05620	COG4215	(ABC) transporter
H2785_RS05625	COG4160	amino acid transport
H2785_RS05630	COG4598	ABC transporter
H2785_RS05640	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H2785_RS05645	COG0826	peptidase U32
H2785_RS05650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2785_RS05665	COG1720	tRNA m6t6A37 methyltransferase activity
H2785_RS05675	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H2785_RS05690	COG0642	Histidine kinase
H2785_RS05700	COG0494	nUDIX hydrolase
H2785_RS05710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H2785_RS05715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H2785_RS05720	COG3139	Protein of unknown function (DUF1315)
H2785_RS05730	COG1301	dicarboxylic acid transport
H2785_RS05735	COG1960	acyl-CoA dehydrogenase activity
H2785_RS05740	COG2819	hydrolase of the alpha beta superfamily
H2785_RS05750	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H2785_RS05760	COG2195	Cleaves the N-terminal amino acid of tripeptides
H2785_RS05765	COG1234	tRNA 3'-trailer cleavage
H2785_RS05795	COG2363	Small membrane protein
H2785_RS05815	COG0513	Belongs to the DEAD box helicase family
H2785_RS05825	COG0778	Nitroreductase
H2785_RS05855	COG1286	toxin biosynthetic process
H2785_RS05880	COG4783	chaperone-mediated protein folding
H2785_RS05885	COG1610	YqeY-like protein
H2785_RS05915	COG0515	serine threonine protein kinase
H2785_RS05915	COG2815	serine threonine protein kinase
H2785_RS05940	COG2831	hemolysin activation secretion protein
H2785_RS05945	COG3210	domain, Protein
H2785_RS05945	COG3210	domain, Protein
H2785_RS06025	COG3111	PFAM Bacterial OB fold (BOF) protein
H2785_RS06050	COG3243	poly(R)-hydroxyalkanoic acid synthase
H2785_RS06055	COG0786	glutamate:sodium symporter activity
H2785_RS06065	COG2186	Transcriptional regulator
H2785_RS06115	COG0477	Major facilitator Superfamily
H2785_RS06140	COG2995	paraquat-inducible protein a
H2785_RS06145	COG3008	intermembrane lipid transfer
H2785_RS06145	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H2785_RS06155	COG1794	racemase activity, acting on amino acids and derivatives
H2785_RS06185	COG1301	dicarboxylic acid transport
H2785_RS06195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2785_RS06200	COG2011	ABC-type metal ion transport system permease component
H2785_RS06205	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H2785_RS06210	COG1464	Belongs to the NlpA lipoprotein family
H2785_RS06215	COG0151	Belongs to the GarS family
H2785_RS06220	COG0138	bifunctional purine biosynthesis protein purh
H2785_RS06225	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H2785_RS06255	COG2308	Evidence 4 Homologs of previously reported genes of
H2785_RS06265	COG1305	Transglutaminase-like
H2785_RS06275	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H2785_RS06280	COG0305	Participates in initiation and elongation during chromosome replication
H2785_RS06305	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H2785_RS06315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H2785_RS06320	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H2785_RS06345	COG0726	polysaccharide deacetylase
H2785_RS06345	COG1649	PFAM Uncharacterised BCR, COG1649
H2785_RS06350	COG1215	transferase activity, transferring glycosyl groups
H2785_RS06355	COG3658	cytochrome
H2785_RS06365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2785_RS06380	COG0583	DNA-binding transcription factor activity
H2785_RS06410	COG1960	acyl-CoA dehydrogenase activity
H2785_RS06415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H2785_RS06420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2785_RS06445	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H2785_RS06450	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H2785_RS06460	COG2205	protein histidine kinase activity
H2785_RS06465	COG0745	RESPONSE REGULATOR receiver
H2785_RS06470	COG0174	glutamine synthetase
H2785_RS06490	COG0729	surface antigen
H2785_RS06515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H2785_RS06520	COG2814	Major facilitator Superfamily
H2785_RS06535	COG0583	DNA-binding transcription factor activity
H2785_RS06550	COG1187	pseudouridine synthase activity
H2785_RS06570	COG0802	atpase or kinase
H2785_RS06575	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H2785_RS06585	COG1923	regulation of RNA biosynthetic process
H2785_RS06590	COG0697	spore germination
H2785_RS06605	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H2785_RS06615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H2785_RS06620	COG0519	Catalyzes the synthesis of GMP from XMP
H2785_RS06620	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H2785_RS06625	COG4302	ethanolamine ammonia-lyase activity
H2785_RS06630	COG4303	Ethanolamine ammonia lyase large subunit
H2785_RS06635	COG0531	amino acid
H2785_RS06655	COG1454	alcohol dehydrogenase
H2785_RS06660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2785_RS06670	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H2785_RS06690	COG0308	aminopeptidase N
H2785_RS06730	COG1605	Chorismate mutase
H2785_RS06745	COG1309	transcriptional regulator
H2785_RS06755	COG0668	transmembrane transport
H2785_RS06785	COG4773	Receptor
H2785_RS06805	COG0488	(ABC) transporter
H2785_RS06810	COG0589	response to stress
H2785_RS06835	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H2785_RS06845	COG3135	benzoate transporter
H2785_RS06850	COG1522	sequence-specific DNA binding
H2785_RS06860	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H2785_RS06865	COG0583	DNA-binding transcription factor activity
H2785_RS06875	COG0183	Belongs to the thiolase family
H2785_RS06885	COG2030	dehydratase
H2785_RS06890	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H2785_RS06905	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H2785_RS06920	COG0824	Thioesterase
H2785_RS06925	COG1454	alcohol dehydrogenase
H2785_RS06935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H2785_RS06955	COG0069	glutamate synthase activity
H2785_RS06975	COG2814	Major facilitator Superfamily
H2785_RS06990	COG0511	ligase activity, forming carbon-carbon bonds
H2785_RS07010	COG1116	anion transmembrane transporter activity
H2785_RS07010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2785_RS07015	COG0745	RESPONSE REGULATOR receiver
H2785_RS07025	COG2146	nitrite reductase [NAD(P)H] activity
H2785_RS07025	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2785_RS07030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2785_RS07035	COG0243	molybdopterin cofactor binding
H2785_RS07045	COG0243	molybdopterin cofactor binding
H2785_RS07050	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H2785_RS07065	COG0315	cyclic pyranopterin monophosphate synthase activity
H2785_RS07065	COG0521	Mo-molybdopterin cofactor biosynthetic process
H2785_RS07070	COG0303	'Molybdopterin
H2785_RS07080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2785_RS07085	COG0697	spore germination
H2785_RS07105	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H2785_RS07110	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H2785_RS07165	COG2204	response regulator
H2785_RS07170	COG3852	Histidine kinase
H2785_RS07190	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H2785_RS07195	COG0575	Belongs to the CDS family
H2785_RS07230	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H2785_RS07245	COG2137	regulation of response to DNA damage stimulus
H2785_RS07255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H2785_RS07260	COG1011	Hydrolase
H2785_RS07285	COG1522	sequence-specific DNA binding
H2785_RS07295	COG1113	amino acid transport
H2785_RS07310	COG0659	secondary active sulfate transmembrane transporter activity
H2785_RS07315	COG2135	peptidase activity
H2785_RS07330	COG5001	Diguanylate cyclase
H2785_RS07330	COG3300	MHYT domain
H2785_RS07345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2785_RS07345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2785_RS07345	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H2785_RS07350	COG1105	Belongs to the carbohydrate kinase PfkB family
H2785_RS07355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H2785_RS07355	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2785_RS07385	COG0024	Methionine aminopeptidase
H2785_RS07390	COG0583	DNA-binding transcription factor activity
H2785_RS07400	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H2785_RS07405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H2785_RS07410	COG0517	IMP dehydrogenase activity
H2785_RS07410	COG0516	GMP reductase activity
H2785_RS07435	COG0552	protein localization to endoplasmic reticulum
H2785_RS07445	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H2785_RS07455	COG4890	Cyd operon protein YbgT
H2785_RS07460	COG1294	oxidase, subunit
H2785_RS07475	COG1585	Membrane protein implicated in regulation of membrane protease activity
H2785_RS07485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2785_RS07490	COG4774	siderophore transport
H2785_RS07505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H2785_RS07510	COG0569	domain protein
H2785_RS07515	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H2785_RS07545	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H2785_RS07550	COG0542	response to heat
H2785_RS07575	COG0446	pyridine nucleotide-disulphide oxidoreductase
H2785_RS07575	COG1902	pentaerythritol trinitrate reductase activity
H2785_RS07620	COG2323	membrane
H2785_RS07625	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H2785_RS07635	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H2785_RS07640	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H2785_RS07645	COG0183	Belongs to the thiolase family
H2785_RS07650	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H2785_RS07655	COG0596	Alpha beta hydrolase
H2785_RS07660	COG2271	Major facilitator Superfamily
H2785_RS07665	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H2785_RS07670	COG3485	protocatechuate 3,4-dioxygenase
H2785_RS07675	COG3485	protocatechuate 3,4-dioxygenase
H2785_RS07680	COG0710	3-dehydroquinate dehydratase activity
H2785_RS07685	COG3420	alginic acid biosynthetic process
H2785_RS07690	COG3659	wide pore channel activity
H2785_RS07695	COG4993	Dehydrogenase
H2785_RS07705	COG2391	methyltransferase activity
H2785_RS07720	COG1414	Transcriptional regulator
H2785_RS07725	COG0583	DNA-binding transcription factor activity
H2785_RS07730	COG1960	acyl-CoA dehydrogenase activity
H2785_RS07755	COG2814	Major facilitator Superfamily
H2785_RS07765	COG0154	amidase activity
H2785_RS07785	COG4638	Rieske (2fe-2S)
H2785_RS07795	COG1028	Short-chain dehydrogenase reductase Sdr
H2785_RS07805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2785_RS07815	COG3733	amine oxidase
H2785_RS07825	COG1012	belongs to the aldehyde dehydrogenase family
H2785_RS07835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2785_RS07840	COG0183	Belongs to the thiolase family
H2785_RS07845	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H2785_RS07850	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H2785_RS07860	COG4829	muconolactone delta-isomerase
H2785_RS07865	COG4948	Mandelate Racemase Muconate Lactonizing
H2785_RS07870	COG0583	DNA-binding transcription factor activity
H2785_RS07880	COG2186	Transcriptional regulator
H2785_RS07900	COG1012	belongs to the aldehyde dehydrogenase family
H2785_RS07915	COG0446	pyridine nucleotide-disulphide oxidoreductase
H2785_RS07915	COG1902	pentaerythritol trinitrate reductase activity
H2785_RS07955	COG1309	transcriptional regulator
H2785_RS07965	COG1335	isochorismatase
H2785_RS07970	COG0583	DNA-binding transcription factor activity
H2785_RS07980	COG0475	glutathione-regulated potassium exporter activity
H2785_RS07980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H2785_RS08030	COG2188	Transcriptional regulator
H2785_RS08045	COG0583	DNA-binding transcription factor activity
H2785_RS08070	COG1566	PFAM secretion protein HlyD family protein
H2785_RS08085	COG1012	belongs to the aldehyde dehydrogenase family
H2785_RS08090	COG0129	dihydroxy-acid dehydratase activity
H2785_RS08100	COG0583	DNA-binding transcription factor activity
H2785_RS08105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2785_RS08115	COG2084	Dehydrogenase
H2785_RS08120	COG2207	Transcriptional regulator
H2785_RS08135	COG1064	alcohol dehydrogenase
H2785_RS08145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2785_RS08150	COG1120	ATPase activity
H2785_RS08170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H2785_RS08220	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H2785_RS08290	COG1073	alpha beta
H2785_RS08300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H2785_RS08330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2785_RS08335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2785_RS08340	COG0745	RESPONSE REGULATOR receiver
H2785_RS08345	COG2205	protein histidine kinase activity
H2785_RS08375	COG2072	flavoprotein involved in K transport
H2785_RS08380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H2785_RS08410	COG1946	Acyl-CoA thioesterase
H2785_RS08415	COG0318	PFAM AMP-dependent synthetase and ligase
H2785_RS08420	COG0583	DNA-binding transcription factor activity
H2785_RS08440	COG1028	Short-chain dehydrogenase reductase Sdr
H2785_RS08445	COG1028	Short-chain dehydrogenase reductase Sdr
H2785_RS08455	COG1960	acyl-CoA dehydrogenase activity
H2785_RS08460	COG0183	Belongs to the thiolase family
H2785_RS08470	COG2271	Major facilitator Superfamily
H2785_RS08475	COG0251	oxidation-reduction process
H2785_RS08485	COG1960	acyl-CoA dehydrogenase activity
H2785_RS08490	COG3231	kanamycin kinase activity
H2785_RS08505	COG1960	acyl-CoA dehydrogenase activity
H2785_RS08510	COG1028	Short-chain dehydrogenase reductase Sdr
H2785_RS08515	COG3829	transcription factor binding
H2785_RS08665	COG3539	Fimbrial protein
H2785_RS08690	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H2785_RS08700	COG0753	catalase activity
H2785_RS08715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H2785_RS08775	COG1535	isochorismatase
H2785_RS08775	COG3433	isochorismatase activity
H2785_RS08780	COG1028	Short-chain dehydrogenase reductase Sdr
H2785_RS08785	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H2785_RS08790	COG4149	molybdate abc transporter
H2785_RS08795	COG0725	ABC transporter, periplasmic molybdate-binding protein
H2785_RS08805	COG4638	Rieske (2fe-2S)
H2785_RS08810	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H2785_RS08815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2785_RS08815	COG0543	2 iron, 2 sulfur cluster binding
H2785_RS08830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2785_RS08840	COG1028	Short-chain dehydrogenase reductase Sdr
H2785_RS08855	COG2207	Transcriptional regulator
H2785_RS08860	COG1028	Short-chain dehydrogenase reductase Sdr
H2785_RS08865	COG2610	gluconate transmembrane transporter activity
H2785_RS08875	COG1309	transcriptional regulator
H2785_RS08895	COG0583	DNA-binding transcription factor activity
H2785_RS08910	COG2031	fatty acid transporter
H2785_RS08915	COG0183	Belongs to the thiolase family
H2785_RS08920	COG0583	DNA-binding transcription factor activity
H2785_RS08925	COG0583	DNA-binding transcription factor activity
H2785_RS08940	COG1027	Aspartate ammonia-lyase
H2785_RS08950	COG0477	Major facilitator Superfamily
H2785_RS08975	COG4521	taurine ABC transporter
H2785_RS08990	COG2188	Transcriptional regulator
H2785_RS09000	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H2785_RS09005	COG1733	regulation of RNA biosynthetic process
H2785_RS09010	COG2207	Transcriptional regulator
H2785_RS09010	COG3708	Transcriptional regulator
H2785_RS09025	COG0730	response to heat
H2785_RS09035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2785_RS09035	COG3453	Protein conserved in bacteria
H2785_RS09045	COG3781	membrane
H2785_RS09050	COG1063	alcohol dehydrogenase
H2785_RS09060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2785_RS09065	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2785_RS09070	COG0022	dehydrogenase e1 component
H2785_RS09075	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H2785_RS09080	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H2785_RS09095	COG3706	GGDEF domain
H2785_RS09110	COG0133	tryptophan synthase activity
H2785_RS09120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H2785_RS09155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H2785_RS09180	COG2226	methyltransferase
H2785_RS09235	COG0842	Transport permease protein
H2785_RS09240	COG0842	Transport permease protein
H2785_RS09245	COG1131	(ABC) transporter
H2785_RS09260	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H2785_RS09265	COG4773	Receptor
H2785_RS09285	COG0730	response to heat
H2785_RS09290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H2785_RS09310	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H2785_RS09325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H2785_RS09355	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H2785_RS09365	COG4264	IucA IucC family
H2785_RS09370	COG4264	IucA IucC family
H2785_RS09375	COG2814	Major facilitator Superfamily
H2785_RS09390	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H2785_RS09405	COG1960	acyl-CoA dehydrogenase activity
H2785_RS09410	COG1960	acyl-CoA dehydrogenase activity
H2785_RS09415	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2785_RS09420	COG2207	Transcriptional regulator
H2785_RS09425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H2785_RS09430	COG0776	regulation of translation
H2785_RS09455	COG0822	iron-sulfur transferase activity
H2785_RS09460	COG0316	Belongs to the HesB IscA family
H2785_RS09490	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H2785_RS09510	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H2785_RS09515	COG0702	epimerase
H2785_RS09550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2785_RS09560	COG0339	signal peptide processing
H2785_RS09605	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H2785_RS09610	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H2785_RS09640	COG0776	regulation of translation
H2785_RS09705	COG0084	hydrolase, TatD family'
H2785_RS09725	COG1663	tetraacyldisaccharide 4'-kinase activity
H2785_RS09730	COG1132	(ABC) transporter
H2785_RS09740	COG0811	peptide transport
H2785_RS09745	COG1475	DNA binding
H2785_RS09750	COG1192	Involved in chromosome partitioning
H2785_RS09760	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H2785_RS09775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H2785_RS09780	COG0191	fructose-bisphosphate aldolase activity
H2785_RS09800	COG0424	maF-like protein
H2785_RS09805	COG2850	peptidyl-arginine hydroxylation
H2785_RS09815	COG0640	Transcriptional regulator
H2785_RS09825	COG3619	membrane
H2785_RS09830	COG3122	Protein conserved in bacteria
H2785_RS09835	COG1132	(ABC) transporter
H2785_RS09855	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H2785_RS09860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H2785_RS09870	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H2785_RS09870	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H2785_RS09870	COG0506	proline dehydrogenase activity
H2785_RS09875	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H2785_RS09890	COG3698	Phosphodiester glycosidase
H2785_RS09900	COG2353	YceI-like domain
H2785_RS09910	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H2785_RS09955	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H2785_RS09955	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H2785_RS09980	COG3539	Fimbrial protein
H2785_RS09985	COG3121	Chaperone
H2785_RS10015	COG0697	spore germination
H2785_RS10025	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H2785_RS10035	COG0583	DNA-binding transcription factor activity
H2785_RS10055	COG1309	transcriptional regulator
H2785_RS10070	COG1522	sequence-specific DNA binding
H2785_RS10080	COG1126	abc transporter atp-binding protein
H2785_RS10085	COG0765	amino acid transport
H2785_RS10090	COG0765	amino acid transport
H2785_RS10120	COG1464	Belongs to the NlpA lipoprotein family
H2785_RS10130	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H2785_RS10135	COG2011	ABC-type metal ion transport system permease component
H2785_RS10140	COG0012	GTP binding
H2785_RS10165	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H2785_RS10205	COG0386	Belongs to the glutathione peroxidase family
H2785_RS10215	COG0436	Aminotransferase
H2785_RS10255	COG3634	alkyl hydroperoxide reductase activity
H2785_RS10270	COG0583	DNA-binding transcription factor activity
H2785_RS10275	COG0798	PFAM Bile acid sodium symporter
H2785_RS10280	COG0640	Transcriptional regulator
H2785_RS10295	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H2785_RS10305	COG0583	DNA-binding transcription factor activity
H2785_RS10315	COG1953	Uracil, thiamine, allantoin
H2785_RS10325	COG2175	clavaminate synthase activity
H2785_RS10330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2785_RS10335	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H2785_RS10340	COG4521	taurine ABC transporter
H2785_RS10350	COG0477	Major facilitator Superfamily
H2785_RS10370	COG1271	oxidase subunit
H2785_RS10375	COG1294	oxidase, subunit
H2785_RS10385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2785_RS10405	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H2785_RS10425	COG3052	prosthetic group binding
H2785_RS10430	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H2785_RS10440	COG0583	DNA-binding transcription factor activity
H2785_RS10450	COG2814	Major facilitator Superfamily
H2785_RS10470	COG1346	cytolysis
H2785_RS10480	COG0583	DNA-binding transcription factor activity
H2785_RS10485	COG0625	glutathione transferase activity
H2785_RS10490	COG0625	glutathione transferase activity
H2785_RS10495	COG0583	DNA-binding transcription factor activity
H2785_RS10510	COG1045	serine acetyltransferase
H2785_RS10515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H2785_RS10520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H2785_RS10525	COG1280	lysine exporter protein (LysE YggA)
H2785_RS10540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2785_RS10545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2785_RS10550	COG1126	abc transporter atp-binding protein
H2785_RS10555	COG0765	amino acid transport
H2785_RS10560	COG0765	amino acid transport
H2785_RS10580	COG0784	Response regulator, receiver
H2785_RS10580	COG2205	protein histidine kinase activity
H2785_RS10600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H2785_RS10620	COG1028	Short-chain dehydrogenase reductase Sdr
H2785_RS10670	COG0583	DNA-binding transcription factor activity
H2785_RS10690	COG0318	PFAM AMP-dependent synthetase and ligase
H2785_RS10695	COG1309	transcriptional regulator
H2785_RS10700	COG1960	acyl-CoA dehydrogenase activity
H2785_RS10705	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H2785_RS10710	COG1024	Enoyl-CoA hydratase
H2785_RS10715	COG4770	biotin carboxylase activity
H2785_RS10725	COG0583	DNA-binding transcription factor activity
H2785_RS10740	COG1960	acyl-CoA dehydrogenase activity
H2785_RS10750	COG2814	Major facilitator Superfamily
H2785_RS10760	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H2785_RS10765	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H2785_RS10770	COG2814	Major facilitator Superfamily
H2785_RS10775	COG1960	acyl-CoA dehydrogenase activity
H2785_RS10780	COG1024	Enoyl-CoA hydratase
H2785_RS10785	COG1028	Short-chain dehydrogenase reductase Sdr
H2785_RS10790	COG1250	3-hydroxyacyl-CoA dehydrogenase
H2785_RS10795	COG0183	Belongs to the thiolase family
H2785_RS10805	COG2814	Major facilitator Superfamily
H2785_RS10815	COG1024	Enoyl-CoA hydratase
H2785_RS10825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H2785_RS10830	COG1960	acyl-CoA dehydrogenase activity
H2785_RS10835	COG2814	Major facilitator Superfamily
H2785_RS10840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H2785_RS10845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H2785_RS10845	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H2785_RS10860	COG3842	ATPase activity
H2785_RS10865	COG1840	ABC-type Fe3 transport system, periplasmic component
H2785_RS10875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2785_RS10880	COG1414	Transcriptional regulator
H2785_RS10890	COG0583	DNA-binding transcription factor activity
H2785_RS10895	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H2785_RS10900	COG1012	belongs to the aldehyde dehydrogenase family
H2785_RS10910	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H2785_RS10920	COG1012	belongs to the aldehyde dehydrogenase family
H2785_RS10925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2785_RS10930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2785_RS10935	COG2267	carboxylic ester hydrolase activity
H2785_RS10955	COG3038	cytochrome b561
H2785_RS10960	COG0753	catalase activity
H2785_RS10965	COG2271	Major facilitator Superfamily
H2785_RS10970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H2785_RS10975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H2785_RS10990	COG2207	Transcriptional regulator
H2785_RS11015	COG2050	protein possibly involved in aromatic compounds catabolism
H2785_RS11025	COG3327	negative regulation of DNA-templated transcription, initiation
H2785_RS11030	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H2785_RS11035	COG0183	Belongs to the thiolase family
H2785_RS11040	COG1250	3-hydroxyacyl-CoA dehydrogenase
H2785_RS11045	COG1024	Enoyl-CoA hydratase
H2785_RS11050	COG1024	Enoyl-CoA hydratase
H2785_RS11055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2785_RS11060	COG2151	metal-sulfur cluster biosynthetic enzyme
H2785_RS11065	COG3396	Phenylacetate-CoA oxygenase
H2785_RS11070	COG3460	Phenylacetate-CoA oxygenase
H2785_RS11075	COG3396	Phenylacetate-CoA oxygenase
H2785_RS11080	COG1012	belongs to the aldehyde dehydrogenase family
H2785_RS11080	COG2030	dehydratase
H2785_RS11085	COG1760	l-serine dehydratase
H2785_RS11090	COG0531	amino acid
H2785_RS11095	COG1012	belongs to the aldehyde dehydrogenase family
H2785_RS11120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H2785_RS11140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2785_RS11150	COG0789	Transcriptional regulator
H2785_RS11160	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H2785_RS11175	COG2807	transmembrane transport
H2785_RS11180	COG0590	tRNA wobble adenosine to inosine editing
H2785_RS11295	COG1116	anion transmembrane transporter activity
H2785_RS11300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2785_RS11310	COG0864	Transcriptional regulator
H2785_RS11320	COG1733	regulation of RNA biosynthetic process
H2785_RS11325	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2785_RS11330	COG0439	Biotin carboxylase
H2785_RS11345	COG1063	alcohol dehydrogenase
H2785_RS11370	COG3210	domain, Protein
H2785_RS11375	COG2831	hemolysin activation secretion protein
H2785_RS11380	COG0038	chloride channel
H2785_RS11385	COG4770	biotin carboxylase activity
H2785_RS11405	COG1914	H( )-stimulated, divalent metal cation uptake system
H2785_RS11410	COG0583	DNA-binding transcription factor activity
H2785_RS11445	COG1250	3-hydroxyacyl-CoA dehydrogenase
H2785_RS11465	COG2814	Major facilitator Superfamily
H2785_RS11475	COG1560	Kdo2-lipid A biosynthetic process
H2785_RS11490	COG1522	sequence-specific DNA binding
H2785_RS11505	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H2785_RS11515	COG4122	O-methyltransferase activity
H2785_RS11545	COG1538	Outer membrane efflux protein
H2785_RS11550	COG1137	ATPase activity
H2785_RS11555	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H2785_RS11565	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H2785_RS11570	COG0517	IMP dehydrogenase activity
H2785_RS11570	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H2785_RS11615	COG2814	Major facilitator Superfamily
H2785_RS11650	COG1278	Cold shock
H2785_RS11655	COG1280	lysine exporter protein (LysE YggA)
H2785_RS11685	COG1570	exodeoxyribonuclease VII activity
H2785_RS11735	COG0583	DNA-binding transcription factor activity
H2785_RS11740	COG4638	Rieske (2fe-2S)
H2785_RS11750	COG0633	Ferredoxin
H2785_RS11750	COG0543	2 iron, 2 sulfur cluster binding
H2785_RS11755	COG1028	Short-chain dehydrogenase reductase Sdr
H2785_RS11760	COG3135	benzoate transporter
H2785_RS11765	COG2814	Major facilitator Superfamily
H2785_RS11780	COG1643	Atp-dependent helicase
H2785_RS11785	COG0450	alkyl hydroperoxide reductase
H2785_RS11795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H2785_RS11805	COG3634	alkyl hydroperoxide reductase activity
H2785_RS11825	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H2785_RS11830	COG0625	glutathione transferase activity
H2785_RS11840	COG2885	chlorophyll binding
H2785_RS11870	COG1546	Belongs to the CinA family
H2785_RS11870	COG1058	Belongs to the CinA family
H2785_RS11875	COG0542	response to heat
H2785_RS11890	COG1765	OsmC-like protein
H2785_RS11905	COG0667	Aldo Keto reductase
H2785_RS11920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H2785_RS11935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H2785_RS11945	COG0527	aspartate kinase activity
H2785_RS11955	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H2785_RS11965	COG3038	cytochrome b561
H2785_RS11970	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H2785_RS11975	COG2252	PERMEase
H2785_RS11985	COG2072	flavoprotein involved in K transport
H2785_RS12000	COG1741	Belongs to the pirin family
H2785_RS12005	COG1309	transcriptional regulator
H2785_RS12015	COG0300	oxidoreductase activity
H2785_RS12020	COG2072	flavoprotein involved in K transport
H2785_RS12025	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H2785_RS12070	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H2785_RS12085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2785_RS12100	COG2814	Major facilitator Superfamily
H2785_RS12105	COG1024	Enoyl-CoA hydratase
H2785_RS12110	COG1012	belongs to the aldehyde dehydrogenase family
H2785_RS12120	COG1960	acyl-CoA dehydrogenase activity
H2785_RS12145	COG2186	Transcriptional regulator
H2785_RS12150	COG1012	belongs to the aldehyde dehydrogenase family
H2785_RS12160	COG4948	Mandelate Racemase Muconate Lactonizing
H2785_RS12165	COG2271	Major facilitator Superfamily
H2785_RS12170	COG2721	sulfolactate sulfo-lyase activity
H2785_RS12175	COG0697	spore germination
H2785_RS12210	COG1113	amino acid transport
H2785_RS12230	COG1012	belongs to the aldehyde dehydrogenase family
H2785_RS12250	COG0531	amino acid
H2785_RS12260	COG1113	amino acid transport
H2785_RS12330	COG4269	membrane
H2785_RS12345	COG0446	pyridine nucleotide-disulphide oxidoreductase
H2785_RS12345	COG1902	pentaerythritol trinitrate reductase activity
H2785_RS12355	COG2203	Gaf domain
H2785_RS12355	COG3706	GGDEF domain
H2785_RS12355	COG4251	negative regulation of phosphorylation
H2785_RS12355	COG5001	Diguanylate cyclase
H2785_RS12365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H2785_RS12385	COG4172	Belongs to the ABC transporter superfamily
H2785_RS12390	COG4239	(ABC) transporter, permease
H2785_RS12395	COG4174	ABC transporter (Permease)
H2785_RS12405	COG1388	LysM domain
H2785_RS12405	COG0741	lytic transglycosylase activity
H2785_RS12405	COG1388	LysM domain
H2785_RS12405	COG0741	lytic transglycosylase activity
H2785_RS12410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H2785_RS12450	COG0583	DNA-binding transcription factor activity
H2785_RS12455	COG1279	arginine transmembrane transporter activity
H2785_RS12475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2785_RS12480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2785_RS12485	COG0006	proline dipeptidase activity
H2785_RS12570	COG0739	heme binding
H2785_RS12815	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H2785_RS12840	COG3384	dioxygenase
H2785_RS12850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H2785_RS12855	COG2878	Part of a membrane complex involved in electron transport
H2785_RS12860	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H2785_RS12885	COG0768	penicillin binding
H2785_RS12890	COG0742	ribosomal rna small subunit methyltransferase
H2785_RS12905	COG0830	nickel cation binding
H2785_RS12915	COG0804	urea catabolic process
H2785_RS12950	COG1253	flavin adenine dinucleotide binding
H2785_RS12955	COG2851	Citrate transporter
H2785_RS13015	COG1773	rubredoxin
H2785_RS13020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2785_RS13030	COG0583	DNA-binding transcription factor activity
H2785_RS13060	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H2785_RS13065	COG4181	ATPase activity
H2785_RS13110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H2785_RS13130	COG0306	phosphate transporter
H2785_RS13140	COG3958	Transketolase
H2785_RS13145	COG3959	Transketolase, thiamine diphosphate binding domain
H2785_RS13150	COG2271	Major facilitator Superfamily
H2785_RS13155	COG1028	Short-chain dehydrogenase reductase Sdr
H2785_RS13160	COG0583	DNA-binding transcription factor activity
H2785_RS13175	COG2223	nitrite transmembrane transporter activity
H2785_RS13180	COG2207	Transcriptional regulator
H2785_RS13185	COG2066	Belongs to the glutaminase family
H2785_RS13190	COG0242	peptide deformylase activity
H2785_RS13195	COG0477	Major facilitator Superfamily
H2785_RS13205	COG0028	Belongs to the TPP enzyme family
H2785_RS13220	COG1028	Short-chain dehydrogenase reductase Sdr
H2785_RS13225	COG2267	carboxylic ester hydrolase activity
H2785_RS13235	COG2271	Major facilitator Superfamily
H2785_RS13250	COG1028	Short-chain dehydrogenase reductase Sdr
H2785_RS13270	COG1414	Transcriptional regulator
H2785_RS13285	COG1024	Enoyl-CoA hydratase
H2785_RS13295	COG1215	transferase activity, transferring glycosyl groups
H2785_RS13300	COG0726	polysaccharide deacetylase
H2785_RS13300	COG1649	PFAM Uncharacterised BCR, COG1649
H2785_RS13310	COG4681	YaeQ
H2785_RS13320	COG0523	cobalamin synthesis protein
H2785_RS13330	COG1607	acyl-coa hydrolase
H2785_RS13340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H2785_RS13345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H2785_RS13350	COG1309	transcriptional regulator
H2785_RS13375	COG2040	homocysteine
H2785_RS13380	COG0531	amino acid
H2785_RS13425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2785_RS13430	COG0477	Major facilitator Superfamily
H2785_RS13540	COG1476	TRANSCRIPTIONal
H2785_RS13570	COG0582	viral genome integration into host DNA
H2785_RS13580	COG0405	Gamma-glutamyltransferase
H2785_RS13585	COG2814	Major facilitator Superfamily
H2785_RS13595	COG2050	protein possibly involved in aromatic compounds catabolism
H2785_RS13610	COG1090	epimerase
H2785_RS13630	COG0420	3'-5' exonuclease activity
H2785_RS13655	COG0735	belongs to the Fur family
H2785_RS13660	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H2785_RS13680	COG0121	glutamine amidotransferase
H2785_RS13695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H2785_RS13705	COG0210	DNA helicase
H2785_RS13710	COG2885	chlorophyll binding
H2785_RS13715	COG0204	Acyl-transferase
H2785_RS13730	COG2894	cell division
H2785_RS13750	COG1280	lysine exporter protein (LysE YggA)
H2785_RS13755	COG1674	ftsk spoiiie
H2785_RS13760	COG0492	ferredoxin-NADP+ reductase activity
H2785_RS13765	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H2785_RS13775	COG0456	acetyltransferase
H2785_RS13820	COG1981	membrane
H2785_RS13835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H2785_RS13835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H2785_RS13855	COG1012	belongs to the aldehyde dehydrogenase family
H2785_RS13865	COG0657	acetylesterase activity
H2785_RS13875	COG0473	3-isopropylmalate dehydrogenase activity
H2785_RS13880	COG0583	DNA-binding transcription factor activity
H2785_RS13900	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H2785_RS13925	COG0564	pseudouridine synthase activity
H2785_RS13935	COG0358	DNA primase activity
H2785_RS13950	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H2785_RS13980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H2785_RS14010	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H2785_RS14020	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H2785_RS14020	COG0352	thiamine-phosphate diphosphorylase activity
H2785_RS14020	COG0351	phosphomethylpyrimidine kinase
H2785_RS14025	COG1652	LysM domain
H2785_RS14050	COG1399	metal-binding, possibly nucleic acid-binding protein
H2785_RS14055	COG3101	peptidyl-lysine hydroxylation
H2785_RS14060	COG0009	L-threonylcarbamoyladenylate synthase
H2785_RS14065	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H2785_RS14070	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H2785_RS14085	COG4106	trans-aconitate 2-methyltransferase activity
H2785_RS14100	COG0596	Alpha beta hydrolase
H2785_RS14100	COG2226	methyltransferase
H2785_RS14100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2785_RS14105	COG1877	trehalose-phosphatase activity
H2785_RS14110	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H2785_RS14115	COG2223	nitrite transmembrane transporter activity
H2785_RS14135	COG1196	nuclear chromosome segregation
H2785_RS14145	COG0730	response to heat
H2785_RS14160	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H2785_RS14170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H2785_RS14220	COG0489	protein tyrosine kinase activity
H2785_RS14230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2785_RS14230	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2785_RS14260	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H2785_RS14265	COG2081	HI0933 family
H2785_RS14275	COG0668	transmembrane transport
H2785_RS14295	COG0583	DNA-binding transcription factor activity
H2785_RS14315	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2785_RS14320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H2785_RS14350	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H2785_RS14390	COG0745	RESPONSE REGULATOR receiver
H2785_RS14410	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H2785_RS14460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2785_RS14475	COG0583	DNA-binding transcription factor activity
H2785_RS14485	COG0583	DNA-binding transcription factor activity
H2785_RS14500	COG0583	DNA-binding transcription factor activity
H2785_RS14505	COG1053	succinate dehydrogenase
H2785_RS14515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H2785_RS14520	COG2814	Major facilitator Superfamily
H2785_RS14525	COG1960	acyl-CoA dehydrogenase activity
H2785_RS14530	COG0583	DNA-binding transcription factor activity
H2785_RS14535	COG1063	alcohol dehydrogenase
H2785_RS14565	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H2785_RS14570	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H2785_RS14575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H2785_RS14595	COG2132	Multicopper oxidase
H2785_RS14605	COG0561	phosphatase activity
H2785_RS14610	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H2785_RS14635	COG1214	PFAM Peptidase M22, glycoprotease
H2785_RS14685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H2785_RS14695	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H2785_RS14700	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H2785_RS14705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H2785_RS14765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H2785_RS14775	COG1846	Transcriptional regulator
H2785_RS14780	COG1764	response to oxidative stress
H2785_RS14820	COG0037	tRNA processing
H2785_RS14830	COG0248	Ppx GppA phosphatase
H2785_RS14860	COG0072	phenylalanine-tRNA ligase activity
H2785_RS14900	COG1238	metal cluster binding
H2785_RS14905	COG0625	glutathione transferase activity
H2785_RS14920	COG0318	PFAM AMP-dependent synthetase and ligase
H2785_RS14925	COG3028	Belongs to the UPF0307 family
H2785_RS14930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2785_RS14950	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H2785_RS14955	COG0617	tRNA 3'-terminal CCA addition
H2785_RS14960	COG1555	photosystem II stabilization
H2785_RS14965	COG3956	TIGRFAM MazG family protein
H2785_RS14975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H2785_RS14995	COG0784	Response regulator, receiver
H2785_RS14995	COG5002	protein histidine kinase activity
H2785_RS14995	COG2205	protein histidine kinase activity
H2785_RS15000	COG1024	Enoyl-CoA hydratase
H2785_RS15005	COG2084	Dehydrogenase
H2785_RS15010	COG3622	Belongs to the hyi family
H2785_RS15050	COG2814	Major facilitator Superfamily
H2785_RS15055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H2785_RS15065	COG0583	DNA-binding transcription factor activity
H2785_RS15075	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H2785_RS15085	COG0084	hydrolase, TatD family'
H2785_RS15100	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H2785_RS15130	COG0440	acetolactate synthase activity
H2785_RS15135	COG0028	Belongs to the TPP enzyme family
H2785_RS15160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2785_RS15165	COG0577	efflux transmembrane transporter activity
H2785_RS15165	COG1136	(ABC) transporter
H2785_RS15170	COG1538	Outer membrane efflux protein
H2785_RS15185	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H2785_RS15190	COG1162	GTPase activity
H2785_RS15200	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H2785_RS15240	COG1426	Protein conserved in bacteria
H2785_RS15275	COG0793	Belongs to the peptidase S41A family
H2785_RS15290	COG2267	carboxylic ester hydrolase activity
H2785_RS15305	COG3265	gluconokinase activity
H2785_RS15315	COG0800	Aldolase
H2785_RS15325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H2785_RS15330	COG0280	phosphate acetyltransferase
H2785_RS15330	COG0857	belongs to the CobB CobQ family
H2785_RS15335	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H2785_RS15335	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H2785_RS15355	COG0740	serine-type endopeptidase activity
H2785_RS15365	COG4774	siderophore transport
H2785_RS15375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H2785_RS15385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2785_RS15385	COG2813	Specifically methylates the guanine in position
H2785_RS15485	COG0788	formyltetrahydrofolate deformylase activity
H2785_RS15510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H2785_RS15510	COG4651	solute:proton antiporter activity
H2785_RS15530	COG0724	RNA recognition motif
H2785_RS15535	COG0210	DNA helicase
H2785_RS15560	COG1733	regulation of RNA biosynthetic process
H2785_RS15570	COG2900	Belongs to the SlyX family
H2785_RS15575	COG0488	(ABC) transporter
H2785_RS15580	COG1280	lysine exporter protein (LysE YggA)
H2785_RS15585	COG1560	Kdo2-lipid A biosynthetic process
H2785_RS15595	COG1301	dicarboxylic acid transport
H2785_RS15650	COG0473	3-isopropylmalate dehydrogenase activity
H2785_RS15715	COG0583	DNA-binding transcription factor activity
H2785_RS15725	COG0625	glutathione transferase activity
H2785_RS15730	COG2378	regulation of single-species biofilm formation
H2785_RS15735	COG0546	phosphoglycolate phosphatase activity
H2785_RS15745	COG1530	ribonuclease E activity
H2785_RS15750	COG0318	PFAM AMP-dependent synthetase and ligase
H2785_RS15765	COG0583	DNA-binding transcription factor activity
H2785_RS15770	COG1028	Short-chain dehydrogenase reductase Sdr
H2785_RS15775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H2785_RS15785	COG0534	Mate efflux family protein
H2785_RS15800	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H2785_RS15830	COG0493	'glutamate synthase
H2785_RS15830	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H2785_RS15840	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H2785_RS15845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2785_RS15860	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H2785_RS15870	COG0644	oxidoreductase
H2785_RS15870	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H2785_RS15875	COG0425	Belongs to the sulfur carrier protein TusA family
H2785_RS15880	COG4535	Mg2 and Co2 transporter CorC
H2785_RS15890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2785_RS15910	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H2785_RS15915	COG0475	glutathione-regulated potassium exporter activity
H2785_RS15915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H2785_RS15930	COG0484	heat shock protein binding
H2785_RS15935	COG0789	Transcriptional regulator
H2785_RS15940	COG0598	Magnesium transport protein CorA
H2785_RS15955	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H2785_RS15960	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2785_RS15965	COG1074	ATP-dependent DNA helicase activity
H2785_RS15970	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H2785_RS15990	COG2226	methyltransferase
H2785_RS16005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2785_RS16010	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H2785_RS16025	COG2111	Na H antiporter
H2785_RS16025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H2785_RS16030	COG1006	Multisubunit Na H antiporter MnhC subunit
H2785_RS16035	COG0651	ATP synthesis coupled electron transport
H2785_RS16040	COG1863	multisubunit Na H antiporter MnhE subunit
H2785_RS16045	COG2212	antiporter activity
H2785_RS16050	COG1320	monovalent cation:proton antiporter activity
H2785_RS16065	COG0195	Participates in both transcription termination and antitermination
H2785_RS16115	COG0237	dephospho-CoA kinase activity
H2785_RS16125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H2785_RS16140	COG0497	DNA recombination
H2785_RS16150	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H2785_RS16180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H2785_RS16180	COG2169	Transcriptional regulator
H2785_RS16185	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H2785_RS16235	COG0789	Transcriptional regulator
H2785_RS16245	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H2785_RS16260	COG0326	Molecular chaperone. Has ATPase activity
H2785_RS16275	COG2056	Na+-H+ antiporter family
H2785_RS16375	COG0546	phosphoglycolate phosphatase activity
H2785_RS16380	COG1716	ATPase activity
H2785_RS16425	COG0181	hydroxymethylbilane synthase activity
H2785_RS16435	COG3275	phosphorelay sensor kinase activity
H2785_RS16460	COG0697	spore germination
H2785_RS16485	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H2785_RS16490	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H2785_RS16495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H2785_RS16500	COG0772	Belongs to the SEDS family
H2785_RS16525	COG4974	Belongs to the 'phage' integrase family
H2785_RS16530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H2785_RS16540	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H2785_RS16550	COG2197	response regulator
H2785_RS16565	COG0793	Belongs to the peptidase S41A family
H2785_RS16570	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H2785_RS16575	COG0795	lipopolysaccharide-transporting ATPase activity
H2785_RS16615	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2785_RS16615	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2785_RS16625	COG0004	ammonium transporteR
H2785_RS16630	COG0347	Belongs to the P(II) protein family
H2785_RS16640	COG0606	chelatase, subunit chli
H2785_RS16650	COG0235	Class ii aldolase
H2785_RS16655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2785_RS16670	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H2785_RS16685	COG0318	PFAM AMP-dependent synthetase and ligase
H2785_RS16695	COG0477	Major facilitator Superfamily
H2785_RS16700	COG2860	membrane
H2785_RS16705	COG3012	SEC-C Motif Domain Protein
H2785_RS16710	COG1253	flavin adenine dinucleotide binding
H2785_RS16720	COG0477	Major facilitator Superfamily
H2785_RS16730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2785_RS16765	COG0655	NAD(P)H dehydrogenase (quinone) activity
H2785_RS16775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H2785_RS16845	COG0758	DNA mediated transformation
H2785_RS16855	COG0697	spore germination
H2785_RS16860	COG1309	transcriptional regulator
H2785_RS16875	COG0386	Belongs to the glutathione peroxidase family
H2785_RS16940	COG1121	(ABC) transporter
H2785_RS16945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H2785_RS16950	COG1280	lysine exporter protein (LysE YggA)
H2785_RS16955	COG2837	iron assimilation
H2785_RS16960	COG0281	malic enzyme
H2785_RS17005	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H2785_RS17005	COG0519	Catalyzes the synthesis of GMP from XMP
H2785_RS17010	COG4399	Belongs to the UPF0754 family
H2785_RS17015	COG2259	Doxx family
H2785_RS17020	COG0586	Pfam SNARE associated Golgi protein
H2785_RS17035	COG1192	Involved in chromosome partitioning
H2785_RS17045	COG0271	Belongs to the BolA IbaG family
H2785_RS17085	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H2785_RS17085	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H2785_RS17085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2785_RS17085	COG3321	synthase
H2785_RS17090	COG1960	acyl-CoA dehydrogenase activity
H2785_RS17100	COG2197	response regulator
H2785_RS17110	COG3916	Acyl-homoserine-lactone synthase
H2785_RS17115	COG0477	Major facilitator Superfamily
H2785_RS17120	COG1024	Enoyl-CoA hydratase
H2785_RS17125	COG1024	Enoyl-CoA hydratase
H2785_RS17130	COG1960	acyl-CoA dehydrogenase activity
H2785_RS17135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H2785_RS17155	COG1113	amino acid transport
H2785_RS17160	COG1113	amino acid transport
H2785_RS17165	COG0251	oxidation-reduction process
H2785_RS17205	COG0564	pseudouridine synthase activity
H2785_RS17275	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H2785_RS17290	COG1802	Transcriptional regulator
H2785_RS17300	COG1448	Aminotransferase
H2785_RS17305	COG0277	FAD linked oxidase domain protein
H2785_RS17315	COG2186	Transcriptional regulator
H2785_RS17325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H2785_RS17330	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H2785_RS17345	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H2785_RS17350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H2785_RS17355	COG1216	Glycosyl transferase, family 2
H2785_RS17385	COG2244	polysaccharide biosynthetic process
H2785_RS17390	COG1216	Glycosyl transferase, family 2
H2785_RS17395	COG2089	acid synthase
H2785_RS17410	COG1083	cytidylyl-transferase
H2785_RS17415	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H2785_RS17420	COG1086	Polysaccharide biosynthesis protein
H2785_RS17425	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H2785_RS17455	COG0728	peptidoglycan biosynthetic process
H2785_RS17460	COG3023	N-Acetylmuramoyl-L-alanine amidase
H2785_RS17520	COG0546	phosphoglycolate phosphatase activity
H2785_RS17525	COG1028	Short-chain dehydrogenase reductase Sdr
H2785_RS17545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2785_RS17550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2785_RS17555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2785_RS17560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2785_RS17565	COG1116	anion transmembrane transporter activity
H2785_RS17570	COG1309	transcriptional regulator
H2785_RS17575	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H2785_RS17585	COG0196	riboflavin kinase activity
H2785_RS17590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H2785_RS17600	COG1047	Peptidyl-prolyl cis-trans
H2785_RS17640	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H2785_RS17645	COG0657	acetylesterase activity
H2785_RS17665	COG0583	DNA-binding transcription factor activity
H2785_RS17695	COG2951	lytic endotransglycosylase activity
H2785_RS17700	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H2785_RS17715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H2785_RS17725	COG0671	phosphoesterase, PA-phosphatase related
H2785_RS17730	COG0861	Integral membrane protein TerC family
H2785_RS17740	COG0754	glutathionylspermidine amidase activity
H2785_RS17750	COG0402	S-adenosylhomocysteine deaminase activity
H2785_RS17765	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H2785_RS17770	COG1230	cation diffusion facilitator family transporter
H2785_RS17785	COG0706	membrane insertase activity