locus-tag	class	description
OIO75_RS00010	COG0592	DNA-directed DNA polymerase activity
OIO75_RS00020	COG0187	DNA topoisomerase II activity
OIO75_RS00030	COG0586	Pfam SNARE associated Golgi protein
OIO75_RS00035	COG0488	(ABC) transporter
OIO75_RS00060	COG0596	Alpha beta hydrolase
OIO75_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
OIO75_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OIO75_RS00110	COG1047	Peptidyl-prolyl cis-trans
OIO75_RS00120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OIO75_RS00125	COG0196	riboflavin kinase activity
OIO75_RS00135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
OIO75_RS00140	COG1309	transcriptional regulator
OIO75_RS00145	COG1116	anion transmembrane transporter activity
OIO75_RS00150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO75_RS00155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OIO75_RS00160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO75_RS00165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO75_RS00185	COG1028	Short-chain dehydrogenase reductase Sdr
OIO75_RS00190	COG0546	phosphoglycolate phosphatase activity
OIO75_RS00215	COG1017	nitric oxide dioxygenase activity
OIO75_RS00215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO75_RS00250	COG3023	N-Acetylmuramoyl-L-alanine amidase
OIO75_RS00255	COG0728	peptidoglycan biosynthetic process
OIO75_RS00285	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
OIO75_RS00305	COG0438	transferase activity, transferring glycosyl groups
OIO75_RS00315	COG0438	transferase activity, transferring glycosyl groups
OIO75_RS00320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
OIO75_RS00330	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
OIO75_RS00340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OIO75_RS00355	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OIO75_RS00360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OIO75_RS00370	COG2186	Transcriptional regulator
OIO75_RS00380	COG0277	FAD linked oxidase domain protein
OIO75_RS00385	COG1448	Aminotransferase
OIO75_RS00395	COG1802	Transcriptional regulator
OIO75_RS00410	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
OIO75_RS00435	COG1051	belongs to the nudix hydrolase family
OIO75_RS00465	COG0564	pseudouridine synthase activity
OIO75_RS00505	COG0251	oxidation-reduction process
OIO75_RS00510	COG1113	amino acid transport
OIO75_RS00515	COG1113	amino acid transport
OIO75_RS00535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OIO75_RS00540	COG1960	acyl-CoA dehydrogenase activity
OIO75_RS00545	COG1024	Enoyl-CoA hydratase
OIO75_RS00550	COG1024	Enoyl-CoA hydratase
OIO75_RS00555	COG0477	Major facilitator Superfamily
OIO75_RS00560	COG3916	Acyl-homoserine-lactone synthase
OIO75_RS00570	COG2197	response regulator
OIO75_RS00580	COG1960	acyl-CoA dehydrogenase activity
OIO75_RS00585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OIO75_RS00585	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
OIO75_RS00585	COG3321	synthase
OIO75_RS00585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OIO75_RS00605	COG2267	carboxylic ester hydrolase activity
OIO75_RS00625	COG0271	Belongs to the BolA IbaG family
OIO75_RS00635	COG1192	Involved in chromosome partitioning
OIO75_RS00650	COG0586	Pfam SNARE associated Golgi protein
OIO75_RS00655	COG2259	Doxx family
OIO75_RS00660	COG4399	Belongs to the UPF0754 family
OIO75_RS00665	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OIO75_RS00665	COG0519	Catalyzes the synthesis of GMP from XMP
OIO75_RS00710	COG0281	malic enzyme
OIO75_RS00720	COG2837	iron assimilation
OIO75_RS00725	COG1280	lysine exporter protein (LysE YggA)
OIO75_RS00730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OIO75_RS00735	COG1121	(ABC) transporter
OIO75_RS00800	COG0386	Belongs to the glutathione peroxidase family
OIO75_RS00815	COG1309	transcriptional regulator
OIO75_RS00820	COG0697	spore germination
OIO75_RS00830	COG0758	DNA mediated transformation
OIO75_RS00900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OIO75_RS00910	COG0655	NAD(P)H dehydrogenase (quinone) activity
OIO75_RS00950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OIO75_RS00955	COG3757	hydrolase, family 25
OIO75_RS00960	COG0477	Major facilitator Superfamily
OIO75_RS00970	COG1253	flavin adenine dinucleotide binding
OIO75_RS00980	COG2860	membrane
OIO75_RS00985	COG0477	Major facilitator Superfamily
OIO75_RS00995	COG0318	PFAM AMP-dependent synthetase and ligase
OIO75_RS01010	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
OIO75_RS01035	COG1061	Type III restriction enzyme res subunit
OIO75_RS01040	COG1002	Type II restriction enzyme, methylase subunits
OIO75_RS01050	COG0659	secondary active sulfate transmembrane transporter activity
OIO75_RS01055	COG0589	response to stress
OIO75_RS01100	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
OIO75_RS01105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
OIO75_RS01110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OIO75_RS01115	COG0772	Belongs to the SEDS family
OIO75_RS01140	COG4974	Belongs to the 'phage' integrase family
OIO75_RS01145	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OIO75_RS01155	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
OIO75_RS01165	COG2197	response regulator
OIO75_RS01180	COG0793	Belongs to the peptidase S41A family
OIO75_RS01185	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
OIO75_RS01190	COG0795	lipopolysaccharide-transporting ATPase activity
OIO75_RS01230	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OIO75_RS01230	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OIO75_RS01240	COG0004	ammonium transporteR
OIO75_RS01245	COG0347	Belongs to the P(II) protein family
OIO75_RS01270	COG1002	Type II restriction enzyme, methylase subunits
OIO75_RS01275	COG1061	Type III restriction enzyme res subunit
OIO75_RS01320	COG0697	spore germination
OIO75_RS01325	COG1538	Outer membrane efflux protein
OIO75_RS01345	COG3275	phosphorelay sensor kinase activity
OIO75_RS01355	COG0181	hydroxymethylbilane synthase activity
OIO75_RS01400	COG1716	ATPase activity
OIO75_RS01405	COG0546	phosphoglycolate phosphatase activity
OIO75_RS01505	COG2056	Na+-H+ antiporter family
OIO75_RS01520	COG0326	Molecular chaperone. Has ATPase activity
OIO75_RS01535	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OIO75_RS01595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OIO75_RS01600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OIO75_RS01600	COG2169	Transcriptional regulator
OIO75_RS01630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
OIO75_RS01640	COG0497	DNA recombination
OIO75_RS01655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OIO75_RS01665	COG0237	dephospho-CoA kinase activity
OIO75_RS01715	COG0195	Participates in both transcription termination and antitermination
OIO75_RS01730	COG1320	monovalent cation:proton antiporter activity
OIO75_RS01735	COG2212	antiporter activity
OIO75_RS01740	COG1863	multisubunit Na H antiporter MnhE subunit
OIO75_RS01745	COG0651	ATP synthesis coupled electron transport
OIO75_RS01750	COG1006	Multisubunit Na H antiporter MnhC subunit
OIO75_RS01755	COG2111	Na H antiporter
OIO75_RS01755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OIO75_RS01770	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OIO75_RS01790	COG2226	methyltransferase
OIO75_RS01810	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
OIO75_RS01815	COG1074	ATP-dependent DNA helicase activity
OIO75_RS01820	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OIO75_RS01825	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OIO75_RS01840	COG0598	Magnesium transport protein CorA
OIO75_RS01845	COG0789	Transcriptional regulator
OIO75_RS01850	COG0484	heat shock protein binding
OIO75_RS01865	COG0475	glutathione-regulated potassium exporter activity
OIO75_RS01865	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OIO75_RS01870	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OIO75_RS01890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OIO75_RS01900	COG4535	Mg2 and Co2 transporter CorC
OIO75_RS01905	COG0425	Belongs to the sulfur carrier protein TusA family
OIO75_RS01915	COG0644	oxidoreductase
OIO75_RS01915	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
OIO75_RS01925	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
OIO75_RS01940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OIO75_RS01945	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
OIO75_RS01955	COG0493	'glutamate synthase
OIO75_RS01955	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
OIO75_RS01980	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OIO75_RS01995	COG0534	Mate efflux family protein
OIO75_RS02005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OIO75_RS02010	COG1028	Short-chain dehydrogenase reductase Sdr
OIO75_RS02015	COG0583	DNA-binding transcription factor activity
OIO75_RS02030	COG0318	PFAM AMP-dependent synthetase and ligase
OIO75_RS02035	COG1530	ribonuclease E activity
OIO75_RS02045	COG0546	phosphoglycolate phosphatase activity
OIO75_RS02050	COG2378	regulation of single-species biofilm formation
OIO75_RS02055	COG0625	glutathione transferase activity
OIO75_RS02065	COG0583	DNA-binding transcription factor activity
OIO75_RS02120	COG0473	3-isopropylmalate dehydrogenase activity
OIO75_RS02175	COG1301	dicarboxylic acid transport
OIO75_RS02185	COG1560	Kdo2-lipid A biosynthetic process
OIO75_RS02190	COG1280	lysine exporter protein (LysE YggA)
OIO75_RS02195	COG0488	(ABC) transporter
OIO75_RS02200	COG2900	Belongs to the SlyX family
OIO75_RS02210	COG1733	regulation of RNA biosynthetic process
OIO75_RS02235	COG0210	DNA helicase
OIO75_RS02240	COG0724	RNA recognition motif
OIO75_RS02260	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OIO75_RS02260	COG4651	solute:proton antiporter activity
OIO75_RS02285	COG0788	formyltetrahydrofolate deformylase activity
OIO75_RS02385	COG2813	Specifically methylates the guanine in position
OIO75_RS02385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OIO75_RS02395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OIO75_RS02405	COG4774	siderophore transport
OIO75_RS02415	COG0740	serine-type endopeptidase activity
OIO75_RS02435	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
OIO75_RS02435	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
OIO75_RS02440	COG0280	phosphate acetyltransferase
OIO75_RS02440	COG0857	belongs to the CobB CobQ family
OIO75_RS02445	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OIO75_RS02455	COG0800	Aldolase
OIO75_RS02465	COG3265	gluconokinase activity
OIO75_RS02470	COG1012	belongs to the aldehyde dehydrogenase family
OIO75_RS02480	COG2267	carboxylic ester hydrolase activity
OIO75_RS02495	COG0793	Belongs to the peptidase S41A family
OIO75_RS02530	COG1426	Protein conserved in bacteria
OIO75_RS02570	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OIO75_RS02580	COG1162	GTPase activity
OIO75_RS02585	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
OIO75_RS02600	COG1538	Outer membrane efflux protein
OIO75_RS02605	COG0577	efflux transmembrane transporter activity
OIO75_RS02605	COG1136	(ABC) transporter
OIO75_RS02610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO75_RS02635	COG0028	Belongs to the TPP enzyme family
OIO75_RS02640	COG0440	acetolactate synthase activity
OIO75_RS02670	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OIO75_RS02685	COG0084	hydrolase, TatD family'
OIO75_RS02695	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
OIO75_RS02705	COG0583	DNA-binding transcription factor activity
OIO75_RS02715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OIO75_RS02785	COG1294	oxidase, subunit
OIO75_RS02790	COG1271	oxidase subunit
OIO75_RS02805	COG4774	siderophore transport
OIO75_RS02875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OIO75_RS02885	COG2814	Major facilitator Superfamily
OIO75_RS02895	COG0697	spore germination
OIO75_RS02930	COG3622	Belongs to the hyi family
OIO75_RS02935	COG2084	Dehydrogenase
OIO75_RS02940	COG1024	Enoyl-CoA hydratase
OIO75_RS02945	COG5002	protein histidine kinase activity
OIO75_RS02945	COG0784	Response regulator, receiver
OIO75_RS02945	COG2205	protein histidine kinase activity
OIO75_RS02965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OIO75_RS02975	COG3956	TIGRFAM MazG family protein
OIO75_RS02980	COG1555	photosystem II stabilization
OIO75_RS02985	COG0617	tRNA 3'-terminal CCA addition
OIO75_RS02990	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OIO75_RS03010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OIO75_RS03015	COG3028	Belongs to the UPF0307 family
OIO75_RS03020	COG0318	PFAM AMP-dependent synthetase and ligase
OIO75_RS03035	COG0625	glutathione transferase activity
OIO75_RS03040	COG1238	metal cluster binding
OIO75_RS03085	COG0072	phenylalanine-tRNA ligase activity
OIO75_RS03115	COG0248	Ppx GppA phosphatase
OIO75_RS03125	COG0037	tRNA processing
OIO75_RS03165	COG1764	response to oxidative stress
OIO75_RS03170	COG1846	Transcriptional regulator
OIO75_RS03180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OIO75_RS03240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OIO75_RS03245	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OIO75_RS03250	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OIO75_RS03320	COG1214	PFAM Peptidase M22, glycoprotease
OIO75_RS03335	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
OIO75_RS03345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OIO75_RS03350	COG0561	phosphatase activity
OIO75_RS03360	COG2132	Multicopper oxidase
OIO75_RS03380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OIO75_RS03385	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
OIO75_RS03390	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
OIO75_RS03420	COG1063	alcohol dehydrogenase
OIO75_RS03425	COG0583	DNA-binding transcription factor activity
OIO75_RS03430	COG1960	acyl-CoA dehydrogenase activity
OIO75_RS03435	COG2814	Major facilitator Superfamily
OIO75_RS03440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OIO75_RS03450	COG1053	succinate dehydrogenase
OIO75_RS03455	COG0583	DNA-binding transcription factor activity
OIO75_RS03470	COG0583	DNA-binding transcription factor activity
OIO75_RS03480	COG0583	DNA-binding transcription factor activity
OIO75_RS03495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO75_RS03540	COG0384	phenazine biosynthesis protein PhzF
OIO75_RS03560	COG1028	Short-chain dehydrogenase reductase Sdr
OIO75_RS03570	COG0477	Major facilitator Superfamily
OIO75_RS03605	COG0697	spore germination
OIO75_RS03610	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OIO75_RS03630	COG0745	RESPONSE REGULATOR receiver
OIO75_RS03670	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
OIO75_RS03700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OIO75_RS03705	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OIO75_RS03730	COG0583	DNA-binding transcription factor activity
OIO75_RS03750	COG0668	transmembrane transport
OIO75_RS03760	COG2081	HI0933 family
OIO75_RS03765	COG2515	1-aminocyclopropane-1-carboxylate deaminase
OIO75_RS03795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OIO75_RS03795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OIO75_RS03805	COG0489	protein tyrosine kinase activity
OIO75_RS03855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OIO75_RS03865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OIO75_RS03880	COG0730	response to heat
OIO75_RS03890	COG1196	nuclear chromosome segregation
OIO75_RS03910	COG2223	nitrite transmembrane transporter activity
OIO75_RS03915	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
OIO75_RS03920	COG1877	trehalose-phosphatase activity
OIO75_RS03925	COG0596	Alpha beta hydrolase
OIO75_RS03925	COG2226	methyltransferase
OIO75_RS03925	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OIO75_RS03940	COG4106	trans-aconitate 2-methyltransferase activity
OIO75_RS03955	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
OIO75_RS03960	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
OIO75_RS03965	COG0009	L-threonylcarbamoyladenylate synthase
OIO75_RS03970	COG3101	peptidyl-lysine hydroxylation
OIO75_RS03975	COG1399	metal-binding, possibly nucleic acid-binding protein
OIO75_RS04000	COG1652	LysM domain
OIO75_RS04005	COG0351	phosphomethylpyrimidine kinase
OIO75_RS04005	COG0352	thiamine-phosphate diphosphorylase activity
OIO75_RS04005	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OIO75_RS04015	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OIO75_RS04045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OIO75_RS04065	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
OIO75_RS04080	COG0358	DNA primase activity
OIO75_RS04090	COG0564	pseudouridine synthase activity
OIO75_RS04115	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OIO75_RS04145	COG0583	DNA-binding transcription factor activity
OIO75_RS04150	COG0473	3-isopropylmalate dehydrogenase activity
OIO75_RS04160	COG0657	acetylesterase activity
OIO75_RS04170	COG1012	belongs to the aldehyde dehydrogenase family
OIO75_RS04190	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
OIO75_RS04190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OIO75_RS04205	COG1981	membrane
OIO75_RS04250	COG0456	acetyltransferase
OIO75_RS04260	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
OIO75_RS04265	COG0492	ferredoxin-NADP+ reductase activity
OIO75_RS04270	COG1674	ftsk spoiiie
OIO75_RS04270	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OIO75_RS04275	COG1280	lysine exporter protein (LysE YggA)
OIO75_RS04290	COG2894	cell division
OIO75_RS04305	COG0204	Acyl-transferase
OIO75_RS04310	COG2885	chlorophyll binding
OIO75_RS04315	COG0210	DNA helicase
OIO75_RS04325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OIO75_RS04340	COG0121	glutamine amidotransferase
OIO75_RS04360	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OIO75_RS04365	COG0735	belongs to the Fur family
OIO75_RS04390	COG0420	3'-5' exonuclease activity
OIO75_RS04410	COG1090	epimerase
OIO75_RS04425	COG2050	protein possibly involved in aromatic compounds catabolism
OIO75_RS04435	COG2814	Major facilitator Superfamily
OIO75_RS04440	COG0405	Gamma-glutamyltransferase
OIO75_RS04520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OIO75_RS04605	COG1484	DNA-dependent DNA replication
OIO75_RS04825	COG2026	Addiction module toxin, RelE StbE family
OIO75_RS04865	COG0592	DNA-directed DNA polymerase activity
OIO75_RS04950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OIO75_RS05010	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
OIO75_RS05020	COG0477	Major facilitator Superfamily
OIO75_RS05025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OIO75_RS05035	COG1595	DNA-templated transcription, initiation
OIO75_RS05090	COG0531	amino acid
OIO75_RS05095	COG2040	homocysteine
OIO75_RS05120	COG1309	transcriptional regulator
OIO75_RS05125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OIO75_RS05130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OIO75_RS05140	COG1607	acyl-coa hydrolase
OIO75_RS05150	COG0523	cobalamin synthesis protein
OIO75_RS05160	COG4681	YaeQ
OIO75_RS05170	COG0726	polysaccharide deacetylase
OIO75_RS05170	COG1649	PFAM Uncharacterised BCR, COG1649
OIO75_RS05175	COG1215	transferase activity, transferring glycosyl groups
OIO75_RS05185	COG1024	Enoyl-CoA hydratase
OIO75_RS05200	COG1414	Transcriptional regulator
OIO75_RS05220	COG1028	Short-chain dehydrogenase reductase Sdr
OIO75_RS05230	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO75_RS05235	COG2271	Major facilitator Superfamily
OIO75_RS05245	COG2267	carboxylic ester hydrolase activity
OIO75_RS05250	COG1028	Short-chain dehydrogenase reductase Sdr
OIO75_RS05265	COG0028	Belongs to the TPP enzyme family
OIO75_RS05275	COG0477	Major facilitator Superfamily
OIO75_RS05280	COG0242	peptide deformylase activity
OIO75_RS05285	COG2066	Belongs to the glutaminase family
OIO75_RS05290	COG2207	Transcriptional regulator
OIO75_RS05310	COG0583	DNA-binding transcription factor activity
OIO75_RS05315	COG1028	Short-chain dehydrogenase reductase Sdr
OIO75_RS05320	COG2271	Major facilitator Superfamily
OIO75_RS05325	COG3959	Transketolase, thiamine diphosphate binding domain
OIO75_RS05330	COG3958	Transketolase
OIO75_RS05340	COG0306	phosphate transporter
OIO75_RS05365	COG1262	PFAM Formylglycine-generating sulfatase enzyme
OIO75_RS05410	COG4181	ATPase activity
OIO75_RS05415	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
OIO75_RS05445	COG0583	DNA-binding transcription factor activity
OIO75_RS05455	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO75_RS05460	COG1773	rubredoxin
OIO75_RS05510	COG2851	Citrate transporter
OIO75_RS05515	COG1253	flavin adenine dinucleotide binding
OIO75_RS05555	COG0804	urea catabolic process
OIO75_RS05565	COG0830	nickel cation binding
OIO75_RS05580	COG0742	ribosomal rna small subunit methyltransferase
OIO75_RS05585	COG0768	penicillin binding
OIO75_RS05610	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OIO75_RS05615	COG2878	Part of a membrane complex involved in electron transport
OIO75_RS05620	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
OIO75_RS05630	COG3384	dioxygenase
OIO75_RS05650	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OIO75_RS05830	COG5410	chromosome segregation
OIO75_RS05995	COG2194	sulfuric ester hydrolase activity
OIO75_RS06030	COG0006	proline dipeptidase activity
OIO75_RS06035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO75_RS06040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO75_RS06060	COG1279	arginine transmembrane transporter activity
OIO75_RS06065	COG0583	DNA-binding transcription factor activity
OIO75_RS06105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OIO75_RS06110	COG0741	lytic transglycosylase activity
OIO75_RS06110	COG0741	lytic transglycosylase activity
OIO75_RS06110	COG1388	LysM domain
OIO75_RS06110	COG1388	LysM domain
OIO75_RS06120	COG4174	ABC transporter (Permease)
OIO75_RS06125	COG4239	(ABC) transporter, permease
OIO75_RS06130	COG4172	Belongs to the ABC transporter superfamily
OIO75_RS06155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OIO75_RS06165	COG2203	Gaf domain
OIO75_RS06165	COG3706	GGDEF domain
OIO75_RS06165	COG4251	negative regulation of phosphorylation
OIO75_RS06165	COG5001	Diguanylate cyclase
OIO75_RS06175	COG1902	pentaerythritol trinitrate reductase activity
OIO75_RS06175	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO75_RS06190	COG4269	membrane
OIO75_RS06210	COG3209	COG3209 Rhs family protein
OIO75_RS06250	COG1113	amino acid transport
OIO75_RS06260	COG0531	amino acid
OIO75_RS06280	COG1012	belongs to the aldehyde dehydrogenase family
OIO75_RS06300	COG1113	amino acid transport
OIO75_RS06345	COG0697	spore germination
OIO75_RS06350	COG2721	sulfolactate sulfo-lyase activity
OIO75_RS06355	COG2271	Major facilitator Superfamily
OIO75_RS06360	COG4948	Mandelate Racemase Muconate Lactonizing
OIO75_RS06370	COG1012	belongs to the aldehyde dehydrogenase family
OIO75_RS06375	COG2186	Transcriptional regulator
OIO75_RS06400	COG1960	acyl-CoA dehydrogenase activity
OIO75_RS06410	COG1012	belongs to the aldehyde dehydrogenase family
OIO75_RS06415	COG1024	Enoyl-CoA hydratase
OIO75_RS06420	COG2814	Major facilitator Superfamily
OIO75_RS06440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO75_RS06485	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
OIO75_RS06490	COG2072	flavoprotein involved in K transport
OIO75_RS06495	COG0300	oxidoreductase activity
OIO75_RS06505	COG1309	transcriptional regulator
OIO75_RS06510	COG1741	Belongs to the pirin family
OIO75_RS06525	COG2072	flavoprotein involved in K transport
OIO75_RS06535	COG2252	PERMEase
OIO75_RS06540	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
OIO75_RS06545	COG3038	cytochrome b561
OIO75_RS06555	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
OIO75_RS06570	COG0527	aspartate kinase activity
OIO75_RS06580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OIO75_RS06595	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OIO75_RS06610	COG0667	Aldo Keto reductase
OIO75_RS06625	COG1765	OsmC-like protein
OIO75_RS06640	COG0542	response to heat
OIO75_RS06675	COG2885	chlorophyll binding
OIO75_RS06685	COG0625	glutathione transferase activity
OIO75_RS06845	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OIO75_RS06865	COG3634	alkyl hydroperoxide reductase activity
OIO75_RS06875	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
OIO75_RS06885	COG0450	alkyl hydroperoxide reductase
OIO75_RS06890	COG1643	Atp-dependent helicase
OIO75_RS06905	COG2814	Major facilitator Superfamily
OIO75_RS06910	COG3135	benzoate transporter
OIO75_RS06915	COG1028	Short-chain dehydrogenase reductase Sdr
OIO75_RS06920	COG0543	2 iron, 2 sulfur cluster binding
OIO75_RS06920	COG0633	Ferredoxin
OIO75_RS06930	COG4638	Rieske (2fe-2S)
OIO75_RS06940	COG0583	DNA-binding transcription factor activity
OIO75_RS06990	COG1570	exodeoxyribonuclease VII activity
OIO75_RS07020	COG1280	lysine exporter protein (LysE YggA)
OIO75_RS07025	COG1278	Cold shock
OIO75_RS07060	COG2814	Major facilitator Superfamily
OIO75_RS07100	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
OIO75_RS07100	COG0517	IMP dehydrogenase activity
OIO75_RS07105	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
OIO75_RS07115	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
OIO75_RS07120	COG1137	ATPase activity
OIO75_RS07155	COG4122	O-methyltransferase activity
OIO75_RS07165	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
OIO75_RS07180	COG1522	sequence-specific DNA binding
OIO75_RS07185	COG5006	permease, DMT superfamily
OIO75_RS07195	COG1560	Kdo2-lipid A biosynthetic process
OIO75_RS07205	COG0598	Magnesium transport protein CorA
OIO75_RS07235	COG2515	1-aminocyclopropane-1-carboxylate deaminase
OIO75_RS07240	COG1116	anion transmembrane transporter activity
OIO75_RS07245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO75_RS07270	COG1250	3-hydroxyacyl-CoA dehydrogenase
OIO75_RS07330	COG1914	H( )-stimulated, divalent metal cation uptake system
OIO75_RS07350	COG4770	biotin carboxylase activity
OIO75_RS07355	COG0038	chloride channel
OIO75_RS07395	COG1309	transcriptional regulator
OIO75_RS07405	COG1063	alcohol dehydrogenase
OIO75_RS07420	COG0439	Biotin carboxylase
OIO75_RS07425	COG2249	NAD(P)H dehydrogenase (quinone) activity
OIO75_RS07430	COG1733	regulation of RNA biosynthetic process
OIO75_RS07440	COG0864	Transcriptional regulator
OIO75_RS07450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OIO75_RS07455	COG1116	anion transmembrane transporter activity
OIO75_RS07580	COG0590	tRNA wobble adenosine to inosine editing
OIO75_RS07585	COG2807	transmembrane transport
OIO75_RS07600	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
OIO75_RS07610	COG0789	Transcriptional regulator
OIO75_RS07620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OIO75_RS07640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OIO75_RS07665	COG1012	belongs to the aldehyde dehydrogenase family
OIO75_RS07670	COG0531	amino acid
OIO75_RS07675	COG1760	l-serine dehydratase
OIO75_RS07680	COG1012	belongs to the aldehyde dehydrogenase family
OIO75_RS07680	COG2030	dehydratase
OIO75_RS07685	COG3396	Phenylacetate-CoA oxygenase
OIO75_RS07690	COG3460	Phenylacetate-CoA oxygenase
OIO75_RS07695	COG3396	Phenylacetate-CoA oxygenase
OIO75_RS07700	COG2151	metal-sulfur cluster biosynthetic enzyme
OIO75_RS07705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO75_RS07710	COG1024	Enoyl-CoA hydratase
OIO75_RS07715	COG1024	Enoyl-CoA hydratase
OIO75_RS07720	COG1250	3-hydroxyacyl-CoA dehydrogenase
OIO75_RS07725	COG0183	Belongs to the thiolase family
OIO75_RS07730	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
OIO75_RS07735	COG3327	negative regulation of DNA-templated transcription, initiation
OIO75_RS07745	COG2050	protein possibly involved in aromatic compounds catabolism
OIO75_RS07755	COG0556	nucleotide-excision repair
OIO75_RS07790	COG1278	Cold shock
OIO75_RS07800	COG2207	Transcriptional regulator
OIO75_RS07885	COG0753	catalase activity
OIO75_RS07890	COG3038	cytochrome b561
OIO75_RS07910	COG2267	carboxylic ester hydrolase activity
OIO75_RS07915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO75_RS07920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OIO75_RS07925	COG1012	belongs to the aldehyde dehydrogenase family
OIO75_RS07935	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
OIO75_RS07945	COG1012	belongs to the aldehyde dehydrogenase family
OIO75_RS07950	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OIO75_RS07955	COG0583	DNA-binding transcription factor activity
OIO75_RS07965	COG1414	Transcriptional regulator
OIO75_RS07970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO75_RS07985	COG1840	ABC-type Fe3 transport system, periplasmic component
OIO75_RS07990	COG3842	ATPase activity
OIO75_RS08010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OIO75_RS08030	COG0583	DNA-binding transcription factor activity
OIO75_RS08040	COG4770	biotin carboxylase activity
OIO75_RS08045	COG1024	Enoyl-CoA hydratase
OIO75_RS08050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OIO75_RS08055	COG1960	acyl-CoA dehydrogenase activity
OIO75_RS08060	COG1309	transcriptional regulator
OIO75_RS08065	COG0318	PFAM AMP-dependent synthetase and ligase
OIO75_RS08085	COG0583	DNA-binding transcription factor activity
OIO75_RS08135	COG1028	Short-chain dehydrogenase reductase Sdr
OIO75_RS08155	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OIO75_RS08175	COG0784	Response regulator, receiver
OIO75_RS08175	COG2205	protein histidine kinase activity
OIO75_RS08195	COG0765	amino acid transport
OIO75_RS08200	COG0765	amino acid transport
OIO75_RS08205	COG1126	abc transporter atp-binding protein
OIO75_RS08210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OIO75_RS08215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OIO75_RS08230	COG1280	lysine exporter protein (LysE YggA)
OIO75_RS08240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OIO75_RS08245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OIO75_RS08250	COG1045	serine acetyltransferase
OIO75_RS08260	COG1028	Short-chain dehydrogenase reductase Sdr
OIO75_RS08265	COG0583	DNA-binding transcription factor activity
OIO75_RS08270	COG0625	glutathione transferase activity
OIO75_RS08275	COG0625	glutathione transferase activity
OIO75_RS08280	COG0583	DNA-binding transcription factor activity
OIO75_RS08290	COG1346	cytolysis
OIO75_RS08310	COG2814	Major facilitator Superfamily
OIO75_RS08320	COG0583	DNA-binding transcription factor activity
OIO75_RS08330	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
OIO75_RS08335	COG3052	prosthetic group binding
OIO75_RS08355	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
OIO75_RS08375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO75_RS08385	COG1294	oxidase, subunit
OIO75_RS08390	COG1271	oxidase subunit
OIO75_RS08410	COG0477	Major facilitator Superfamily
OIO75_RS08420	COG4521	taurine ABC transporter
OIO75_RS08440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO75_RS08445	COG2175	clavaminate synthase activity
OIO75_RS08455	COG1953	Uracil, thiamine, allantoin
OIO75_RS08465	COG0583	DNA-binding transcription factor activity
OIO75_RS08475	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
OIO75_RS08490	COG0640	Transcriptional regulator
OIO75_RS08495	COG0798	PFAM Bile acid sodium symporter
OIO75_RS08500	COG0583	DNA-binding transcription factor activity
OIO75_RS08515	COG3634	alkyl hydroperoxide reductase activity
OIO75_RS08550	COG1301	dicarboxylic acid transport
OIO75_RS08555	COG0436	Aminotransferase
OIO75_RS08565	COG0386	Belongs to the glutathione peroxidase family
OIO75_RS08605	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
OIO75_RS08630	COG0012	GTP binding
OIO75_RS08635	COG2011	ABC-type metal ion transport system permease component
OIO75_RS08640	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OIO75_RS08650	COG1464	Belongs to the NlpA lipoprotein family
OIO75_RS08680	COG0765	amino acid transport
OIO75_RS08685	COG0765	amino acid transport
OIO75_RS08690	COG1126	abc transporter atp-binding protein
OIO75_RS08700	COG1522	sequence-specific DNA binding
OIO75_RS08715	COG1309	transcriptional regulator
OIO75_RS08735	COG0583	DNA-binding transcription factor activity
OIO75_RS08745	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
OIO75_RS08755	COG0697	spore germination
OIO75_RS08780	COG3121	Chaperone
OIO75_RS08785	COG3539	Fimbrial protein
OIO75_RS08810	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
OIO75_RS08810	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OIO75_RS08855	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
OIO75_RS08865	COG2353	YceI-like domain
OIO75_RS08875	COG3698	Phosphodiester glycosidase
OIO75_RS08890	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
OIO75_RS08895	COG0506	proline dehydrogenase activity
OIO75_RS08895	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
OIO75_RS08895	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
OIO75_RS08905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OIO75_RS08910	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
OIO75_RS08930	COG1132	(ABC) transporter
OIO75_RS08935	COG3122	Protein conserved in bacteria
OIO75_RS08940	COG3619	membrane
OIO75_RS08950	COG0640	Transcriptional regulator
OIO75_RS08960	COG2850	peptidyl-arginine hydroxylation
OIO75_RS08965	COG0424	maF-like protein
OIO75_RS08985	COG0191	fructose-bisphosphate aldolase activity
OIO75_RS08990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OIO75_RS09005	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
OIO75_RS09015	COG1192	Involved in chromosome partitioning
OIO75_RS09020	COG1475	DNA binding
OIO75_RS09025	COG0811	peptide transport
OIO75_RS09035	COG1132	(ABC) transporter
OIO75_RS09040	COG1663	tetraacyldisaccharide 4'-kinase activity
OIO75_RS09060	COG0084	hydrolase, TatD family'
OIO75_RS09125	COG0776	regulation of translation
OIO75_RS09155	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
OIO75_RS09160	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OIO75_RS09195	COG4166	transmembrane transport
OIO75_RS09205	COG0339	signal peptide processing
OIO75_RS09215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OIO75_RS09250	COG0702	epimerase
OIO75_RS09255	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OIO75_RS09275	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OIO75_RS09305	COG0316	Belongs to the HesB IscA family
OIO75_RS09310	COG0822	iron-sulfur transferase activity
OIO75_RS09335	COG0776	regulation of translation
OIO75_RS09340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OIO75_RS09345	COG2207	Transcriptional regulator
OIO75_RS09350	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OIO75_RS09355	COG1960	acyl-CoA dehydrogenase activity
OIO75_RS09360	COG1960	acyl-CoA dehydrogenase activity
OIO75_RS09375	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OIO75_RS09390	COG2814	Major facilitator Superfamily
OIO75_RS09395	COG4264	IucA IucC family
OIO75_RS09400	COG4264	IucA IucC family
OIO75_RS09410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OIO75_RS09440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OIO75_RS09455	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
OIO75_RS09460	COG0406	alpha-ribazole phosphatase activity
OIO75_RS09475	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OIO75_RS09480	COG0730	response to heat
OIO75_RS09505	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OIO75_RS09520	COG1131	(ABC) transporter
OIO75_RS09525	COG0842	Transport permease protein
OIO75_RS09530	COG0842	Transport permease protein
OIO75_RS09585	COG2226	methyltransferase
OIO75_RS09610	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OIO75_RS09645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OIO75_RS09655	COG0133	tryptophan synthase activity
OIO75_RS09670	COG3706	GGDEF domain
OIO75_RS09685	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OIO75_RS09690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
OIO75_RS09695	COG0022	dehydrogenase e1 component
OIO75_RS09700	COG0508	dehydrogenase complex catalyzes the overall conversion of
OIO75_RS09705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OIO75_RS09715	COG1063	alcohol dehydrogenase
OIO75_RS09720	COG3781	membrane
OIO75_RS09730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OIO75_RS09730	COG3453	Protein conserved in bacteria
OIO75_RS09745	COG0730	response to heat
OIO75_RS09760	COG2207	Transcriptional regulator
OIO75_RS09760	COG3708	Transcriptional regulator
OIO75_RS09765	COG1733	regulation of RNA biosynthetic process
OIO75_RS09770	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
OIO75_RS09780	COG2188	Transcriptional regulator
OIO75_RS09795	COG4521	taurine ABC transporter
OIO75_RS09800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO75_RS09820	COG0477	Major facilitator Superfamily
OIO75_RS09830	COG1027	Aspartate ammonia-lyase
OIO75_RS09850	COG0583	DNA-binding transcription factor activity
OIO75_RS09855	COG0583	DNA-binding transcription factor activity
OIO75_RS09860	COG0183	Belongs to the thiolase family
OIO75_RS09865	COG2031	fatty acid transporter
OIO75_RS09880	COG0583	DNA-binding transcription factor activity
OIO75_RS09890	COG2610	gluconate transmembrane transporter activity
OIO75_RS09895	COG1028	Short-chain dehydrogenase reductase Sdr
OIO75_RS09900	COG2207	Transcriptional regulator
OIO75_RS09915	COG1028	Short-chain dehydrogenase reductase Sdr
OIO75_RS09925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO75_RS09940	COG0543	2 iron, 2 sulfur cluster binding
OIO75_RS09940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO75_RS09945	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
OIO75_RS09950	COG4638	Rieske (2fe-2S)
OIO75_RS09960	COG0725	ABC transporter, periplasmic molybdate-binding protein
OIO75_RS09965	COG4149	molybdate abc transporter
OIO75_RS09970	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
OIO75_RS09975	COG1028	Short-chain dehydrogenase reductase Sdr
OIO75_RS09980	COG3433	isochorismatase activity
OIO75_RS09980	COG1535	isochorismatase
OIO75_RS10040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OIO75_RS10070	COG0753	catalase activity
OIO75_RS10080	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
OIO75_RS10105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OIO75_RS10110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO75_RS10115	COG0745	RESPONSE REGULATOR receiver
OIO75_RS10120	COG2205	protein histidine kinase activity
OIO75_RS10130	COG2207	Transcriptional regulator
OIO75_RS10140	COG1028	Short-chain dehydrogenase reductase Sdr
OIO75_RS10170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OIO75_RS10170	COG3320	Male sterility
OIO75_RS10175	COG2814	Major facilitator Superfamily
OIO75_RS10200	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
OIO75_RS10250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OIO75_RS10270	COG1120	ATPase activity
OIO75_RS10275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OIO75_RS10285	COG1064	alcohol dehydrogenase
OIO75_RS10300	COG2207	Transcriptional regulator
OIO75_RS10305	COG2084	Dehydrogenase
OIO75_RS10315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OIO75_RS10320	COG0583	DNA-binding transcription factor activity
OIO75_RS10330	COG0129	dihydroxy-acid dehydratase activity
OIO75_RS10335	COG1012	belongs to the aldehyde dehydrogenase family
OIO75_RS10340	COG1846	Transcriptional regulator
OIO75_RS10345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO75_RS10350	COG1960	acyl-CoA dehydrogenase activity
OIO75_RS10355	COG0477	Major facilitator Superfamily
OIO75_RS10370	COG3971	2-oxopent-4-enoate hydratase activity
OIO75_RS10380	COG3384	dioxygenase
OIO75_RS10385	COG1012	belongs to the aldehyde dehydrogenase family
OIO75_RS10395	COG0179	Fumarylacetoacetate (FAA) hydrolase
OIO75_RS10405	COG2814	Major facilitator Superfamily
OIO75_RS10410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OIO75_RS10425	COG1012	belongs to the aldehyde dehydrogenase family
OIO75_RS10445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OIO75_RS10465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OIO75_RS10500	COG0583	DNA-binding transcription factor activity
OIO75_RS10515	COG2188	Transcriptional regulator
OIO75_RS10570	COG1473	amidohydrolase
OIO75_RS10580	COG0475	glutathione-regulated potassium exporter activity
OIO75_RS10580	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OIO75_RS10590	COG0583	DNA-binding transcription factor activity
OIO75_RS10595	COG1335	isochorismatase
OIO75_RS10605	COG1309	transcriptional regulator
OIO75_RS10640	COG1902	pentaerythritol trinitrate reductase activity
OIO75_RS10640	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO75_RS10645	COG1846	Transcriptional regulator
OIO75_RS10670	COG0753	catalase activity
OIO75_RS10685	COG1012	belongs to the aldehyde dehydrogenase family
OIO75_RS10700	COG3162	membrane
OIO75_RS10710	COG3829	transcription factor binding
OIO75_RS10715	COG1028	Short-chain dehydrogenase reductase Sdr
OIO75_RS10720	COG1960	acyl-CoA dehydrogenase activity
OIO75_RS10735	COG3231	kanamycin kinase activity
OIO75_RS10740	COG1012	belongs to the aldehyde dehydrogenase family
OIO75_RS10760	COG2186	Transcriptional regulator
OIO75_RS10770	COG0583	DNA-binding transcription factor activity
OIO75_RS10775	COG4948	Mandelate Racemase Muconate Lactonizing
OIO75_RS10780	COG4829	muconolactone delta-isomerase
OIO75_RS10790	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
OIO75_RS10795	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OIO75_RS10800	COG0183	Belongs to the thiolase family
OIO75_RS10805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OIO75_RS10815	COG1012	belongs to the aldehyde dehydrogenase family
OIO75_RS10825	COG3733	amine oxidase
OIO75_RS10835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO75_RS10845	COG1028	Short-chain dehydrogenase reductase Sdr
OIO75_RS10855	COG4638	Rieske (2fe-2S)
OIO75_RS10875	COG0154	amidase activity
OIO75_RS10885	COG2814	Major facilitator Superfamily
OIO75_RS10910	COG1960	acyl-CoA dehydrogenase activity
OIO75_RS10915	COG0583	DNA-binding transcription factor activity
OIO75_RS10920	COG1414	Transcriptional regulator
OIO75_RS10935	COG2391	methyltransferase activity
OIO75_RS10945	COG4993	Dehydrogenase
OIO75_RS10950	COG3659	wide pore channel activity
OIO75_RS10955	COG3420	alginic acid biosynthetic process
OIO75_RS10960	COG0710	3-dehydroquinate dehydratase activity
OIO75_RS10965	COG3485	protocatechuate 3,4-dioxygenase
OIO75_RS10970	COG3485	protocatechuate 3,4-dioxygenase
OIO75_RS10975	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OIO75_RS10980	COG2271	Major facilitator Superfamily
OIO75_RS10985	COG0596	Alpha beta hydrolase
OIO75_RS10990	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OIO75_RS10995	COG0183	Belongs to the thiolase family
OIO75_RS11000	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OIO75_RS11005	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
OIO75_RS11015	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
OIO75_RS11020	COG2323	membrane
OIO75_RS11065	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO75_RS11065	COG1902	pentaerythritol trinitrate reductase activity
OIO75_RS11080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OIO75_RS11090	COG0542	response to heat
OIO75_RS11095	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
OIO75_RS11125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OIO75_RS11130	COG0569	domain protein
OIO75_RS11135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OIO75_RS11150	COG4774	siderophore transport
OIO75_RS11155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OIO75_RS11165	COG1585	Membrane protein implicated in regulation of membrane protease activity
OIO75_RS11180	COG1294	oxidase, subunit
OIO75_RS11185	COG4890	Cyd operon protein YbgT
OIO75_RS11195	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
OIO75_RS11205	COG0552	protein localization to endoplasmic reticulum
OIO75_RS11230	COG0517	IMP dehydrogenase activity
OIO75_RS11230	COG0516	GMP reductase activity
OIO75_RS11235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OIO75_RS11240	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
OIO75_RS11250	COG0583	DNA-binding transcription factor activity
OIO75_RS11255	COG0024	Methionine aminopeptidase
OIO75_RS11285	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OIO75_RS11285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OIO75_RS11290	COG1105	Belongs to the carbohydrate kinase PfkB family
OIO75_RS11295	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OIO75_RS11295	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OIO75_RS11295	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
OIO75_RS11315	COG3300	MHYT domain
OIO75_RS11315	COG5001	Diguanylate cyclase
OIO75_RS11330	COG2135	peptidase activity
OIO75_RS11335	COG0659	secondary active sulfate transmembrane transporter activity
OIO75_RS11355	COG1113	amino acid transport
OIO75_RS11365	COG1522	sequence-specific DNA binding
OIO75_RS11390	COG1011	Hydrolase
OIO75_RS11395	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
OIO75_RS11405	COG2137	regulation of response to DNA damage stimulus
OIO75_RS11420	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OIO75_RS11440	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OIO75_RS11455	COG0575	Belongs to the CDS family
OIO75_RS11460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OIO75_RS11480	COG3852	Histidine kinase
OIO75_RS11485	COG2204	response regulator
OIO75_RS11540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OIO75_RS11545	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
OIO75_RS11565	COG0697	spore germination
OIO75_RS11570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO75_RS11585	COG0521	Mo-molybdopterin cofactor biosynthetic process
OIO75_RS11585	COG0315	cyclic pyranopterin monophosphate synthase activity
OIO75_RS11605	COG0243	molybdopterin cofactor binding
OIO75_RS11615	COG0243	molybdopterin cofactor binding
OIO75_RS11620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO75_RS11625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO75_RS11625	COG2146	nitrite reductase [NAD(P)H] activity
OIO75_RS11635	COG0745	RESPONSE REGULATOR receiver
OIO75_RS11640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO75_RS11640	COG1116	anion transmembrane transporter activity
OIO75_RS11660	COG0511	ligase activity, forming carbon-carbon bonds
OIO75_RS11675	COG2814	Major facilitator Superfamily
OIO75_RS11695	COG0069	glutamate synthase activity
OIO75_RS11715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OIO75_RS11725	COG1454	alcohol dehydrogenase
OIO75_RS11730	COG0824	Thioesterase
OIO75_RS11745	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OIO75_RS11760	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OIO75_RS11765	COG2030	dehydratase
OIO75_RS11775	COG0183	Belongs to the thiolase family
OIO75_RS11785	COG0583	DNA-binding transcription factor activity
OIO75_RS11790	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OIO75_RS11800	COG1522	sequence-specific DNA binding
OIO75_RS11805	COG3135	benzoate transporter
OIO75_RS11815	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
OIO75_RS11840	COG0589	response to stress
OIO75_RS11845	COG0488	(ABC) transporter
OIO75_RS11865	COG4773	Receptor
OIO75_RS11895	COG0668	transmembrane transport
OIO75_RS11905	COG1309	transcriptional regulator
OIO75_RS11925	COG1605	Chorismate mutase
OIO75_RS11945	COG0308	aminopeptidase N
OIO75_RS11965	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
OIO75_RS11975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OIO75_RS11980	COG1454	alcohol dehydrogenase
OIO75_RS12000	COG0531	amino acid
OIO75_RS12005	COG4303	Ethanolamine ammonia lyase large subunit
OIO75_RS12010	COG4302	ethanolamine ammonia-lyase activity
OIO75_RS12015	COG0519	Catalyzes the synthesis of GMP from XMP
OIO75_RS12015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OIO75_RS12020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OIO75_RS12045	COG0697	spore germination
OIO75_RS12050	COG1923	regulation of RNA biosynthetic process
OIO75_RS12060	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OIO75_RS12065	COG0802	atpase or kinase
OIO75_RS12085	COG1187	pseudouridine synthase activity
OIO75_RS12100	COG0583	DNA-binding transcription factor activity
OIO75_RS12115	COG2814	Major facilitator Superfamily
OIO75_RS12120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OIO75_RS12145	COG0729	surface antigen
OIO75_RS12165	COG0174	glutamine synthetase
OIO75_RS12170	COG0745	RESPONSE REGULATOR receiver
OIO75_RS12185	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
OIO75_RS12190	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
OIO75_RS12200	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
OIO75_RS12215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO75_RS12220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OIO75_RS12225	COG1960	acyl-CoA dehydrogenase activity
OIO75_RS12240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO75_RS12245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO75_RS12265	COG0583	DNA-binding transcription factor activity
OIO75_RS12280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OIO75_RS12290	COG3658	cytochrome
OIO75_RS12295	COG1215	transferase activity, transferring glycosyl groups
OIO75_RS12300	COG1649	PFAM Uncharacterised BCR, COG1649
OIO75_RS12300	COG0726	polysaccharide deacetylase
OIO75_RS12325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OIO75_RS12330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OIO75_RS12340	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
OIO75_RS12365	COG0305	Participates in initiation and elongation during chromosome replication
OIO75_RS12370	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OIO75_RS12380	COG1305	Transglutaminase-like
OIO75_RS12390	COG2308	Evidence 4 Homologs of previously reported genes of
OIO75_RS12420	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
OIO75_RS12425	COG0138	bifunctional purine biosynthesis protein purh
OIO75_RS12430	COG0151	Belongs to the GarS family
OIO75_RS12435	COG1464	Belongs to the NlpA lipoprotein family
OIO75_RS12440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OIO75_RS12445	COG2011	ABC-type metal ion transport system permease component
OIO75_RS12450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OIO75_RS12460	COG1301	dicarboxylic acid transport
OIO75_RS12490	COG1794	racemase activity, acting on amino acids and derivatives
OIO75_RS12500	COG3008	intermembrane lipid transfer
OIO75_RS12500	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OIO75_RS12505	COG2995	paraquat-inducible protein a
OIO75_RS12535	COG0477	Major facilitator Superfamily
OIO75_RS12545	COG2186	Transcriptional regulator
OIO75_RS12555	COG0786	glutamate:sodium symporter activity
OIO75_RS12560	COG3243	poly(R)-hydroxyalkanoic acid synthase
OIO75_RS12585	COG3111	PFAM Bacterial OB fold (BOF) protein
OIO75_RS12655	COG2815	serine threonine protein kinase
OIO75_RS12655	COG0515	serine threonine protein kinase
OIO75_RS12685	COG1610	YqeY-like protein
OIO75_RS12690	COG4783	chaperone-mediated protein folding
OIO75_RS12715	COG1286	toxin biosynthetic process
OIO75_RS12745	COG0778	Nitroreductase
OIO75_RS12755	COG0513	Belongs to the DEAD box helicase family
OIO75_RS12780	COG2363	Small membrane protein
OIO75_RS12810	COG4650	regulator
OIO75_RS12815	COG1234	tRNA 3'-trailer cleavage
OIO75_RS12820	COG1690	Belongs to the RtcB family
OIO75_RS12840	COG2195	Cleaves the N-terminal amino acid of tripeptides
OIO75_RS12850	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
OIO75_RS12860	COG2819	hydrolase of the alpha beta superfamily
OIO75_RS12865	COG1960	acyl-CoA dehydrogenase activity
OIO75_RS12870	COG1301	dicarboxylic acid transport
OIO75_RS12880	COG3139	Protein of unknown function (DUF1315)
OIO75_RS12885	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OIO75_RS12890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OIO75_RS12900	COG0494	nUDIX hydrolase
OIO75_RS12910	COG0642	Histidine kinase
OIO75_RS12925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OIO75_RS12935	COG1720	tRNA m6t6A37 methyltransferase activity
OIO75_RS12950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO75_RS12955	COG0826	peptidase U32
OIO75_RS12960	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OIO75_RS12970	COG4598	ABC transporter
OIO75_RS12975	COG4160	amino acid transport
OIO75_RS12980	COG4215	(ABC) transporter
OIO75_RS12995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO75_RS13040	COG1131	(ABC) transporter
OIO75_RS13045	COG0842	Transport permease protein
OIO75_RS13060	COG0772	Belongs to the SEDS family
OIO75_RS13065	COG2951	lytic endotransglycosylase activity
OIO75_RS13090	COG2207	Transcriptional regulator
OIO75_RS13105	COG0052	Belongs to the universal ribosomal protein uS2 family
OIO75_RS13110	COG0024	Methionine aminopeptidase
OIO75_RS13130	COG2223	nitrite transmembrane transporter activity
OIO75_RS13140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OIO75_RS13145	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OIO75_RS13150	COG1960	acyl-CoA dehydrogenase activity
OIO75_RS13165	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
OIO75_RS13170	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
OIO75_RS13175	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OIO75_RS13195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OIO75_RS13200	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
OIO75_RS13205	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OIO75_RS13240	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
OIO75_RS13250	COG0174	glutamine synthetase
OIO75_RS13265	COG0512	Glutamine amidotransferase of anthranilate synthase
OIO75_RS13270	COG0308	aminopeptidase N
OIO75_RS13300	COG1529	Aldehyde oxidase and xanthine dehydrogenase
OIO75_RS13310	COG0302	gtp cyclohydrolase
OIO75_RS13330	COG3739	integral membrane protein
OIO75_RS13350	COG2977	Belongs to the P-Pant transferase superfamily
OIO75_RS13355	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
OIO75_RS13360	COG1132	(ABC) transporter
OIO75_RS13365	COG1132	(ABC) transporter
OIO75_RS13380	COG1535	isochorismatase
OIO75_RS13380	COG3433	isochorismatase activity
OIO75_RS13385	COG1021	2,3-dihydroxybenzoate-AMP ligase
OIO75_RS13390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO75_RS13400	COG4774	siderophore transport
OIO75_RS13405	COG4607	ABC-type enterochelin transport system periplasmic component
OIO75_RS13410	COG4604	ABC transporter, ATP-binding protein
OIO75_RS13415	COG4605	iron ion homeostasis
OIO75_RS13420	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OIO75_RS13430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO75_RS13445	COG2964	Protein conserved in bacteria
OIO75_RS13455	COG1741	Belongs to the pirin family
OIO75_RS13485	COG2130	NADP-dependent
OIO75_RS13495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OIO75_RS13505	COG0596	Alpha beta hydrolase
OIO75_RS13520	COG0583	DNA-binding transcription factor activity
OIO75_RS13525	COG1335	isochorismatase
OIO75_RS13565	COG2879	small protein
OIO75_RS13570	COG1966	Carbon starvation protein
OIO75_RS13590	COG4943	cyclic-guanylate-specific phosphodiesterase activity
OIO75_RS13615	COG1067	ATP-dependent peptidase activity
OIO75_RS13620	COG0583	DNA-binding transcription factor activity
OIO75_RS13645	COG1686	Belongs to the peptidase S11 family
OIO75_RS13650	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
OIO75_RS13685	COG0616	signal peptide processing
OIO75_RS13690	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OIO75_RS13700	COG0573	inorganic phosphate transmembrane transporter activity
OIO75_RS13705	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OIO75_RS13710	COG1113	amino acid transport
OIO75_RS13715	COG3961	Belongs to the TPP enzyme family
OIO75_RS13720	COG1522	sequence-specific DNA binding
OIO75_RS13730	COG0076	glutamate decarboxylase activity
OIO75_RS13735	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OIO75_RS13745	COG1309	transcriptional regulator
OIO75_RS13760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO75_RS13795	COG0352	thiamine-phosphate diphosphorylase activity
OIO75_RS13820	COG0612	Peptidase, M16
OIO75_RS13830	COG1823	symporter activity
OIO75_RS13835	COG0583	DNA-binding transcription factor activity
OIO75_RS13840	COG0477	Major facilitator Superfamily
OIO75_RS13865	COG0582	viral genome integration into host DNA
OIO75_RS14000	COG4695	Portal protein
OIO75_RS14195	COG1187	pseudouridine synthase activity
OIO75_RS14210	COG1686	Belongs to the peptidase S11 family
OIO75_RS14215	COG1252	NADH dehydrogenase
OIO75_RS14230	COG2070	2-Nitropropane dioxygenase
OIO75_RS14285	COG0556	nucleotide-excision repair
OIO75_RS14305	COG0436	Aminotransferase
OIO75_RS14315	COG0443	Heat shock 70 kDa protein
OIO75_RS14345	COG4221	oxidoreductase activity
OIO75_RS14355	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
OIO75_RS14360	COG1381	Involved in DNA repair and RecF pathway recombination
OIO75_RS14370	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
OIO75_RS14385	COG0681	Belongs to the peptidase S26 family
OIO75_RS14395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OIO75_RS14405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OIO75_RS14425	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OIO75_RS14430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OIO75_RS14435	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
OIO75_RS14445	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
OIO75_RS14450	COG4208	sulfate ABC transporter
OIO75_RS14455	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
OIO75_RS14460	COG0583	DNA-binding transcription factor activity
OIO75_RS14465	COG4625	pathogenesis
OIO75_RS14480	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
OIO75_RS14495	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
OIO75_RS14505	COG1051	belongs to the nudix hydrolase family
OIO75_RS14505	COG1056	cytidyltransferase-related domain
OIO75_RS14510	COG1024	Enoyl-CoA hydratase
OIO75_RS14525	COG2814	Major facilitator Superfamily
OIO75_RS14530	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OIO75_RS14530	COG0047	phosphoribosylformylglycinamidine synthase activity
OIO75_RS14550	COG1473	amidohydrolase
OIO75_RS14555	COG0824	Thioesterase
OIO75_RS14575	COG0823	Involved in the tonB-independent uptake of proteins
OIO75_RS14595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OIO75_RS14630	COG0628	permease
OIO75_RS14640	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OIO75_RS14645	COG0596	Alpha beta hydrolase
OIO75_RS14650	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OIO75_RS14650	COG0616	signal peptide processing
OIO75_RS14660	COG2333	competence protein COMEC
OIO75_RS14660	COG0658	competence protein
OIO75_RS14665	COG1136	(ABC) transporter
OIO75_RS14670	COG4591	ABC-type transport system involved in lipoprotein release permease component
OIO75_RS14705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO75_RS14725	COG0463	Glycosyl transferase, family 2
OIO75_RS14755	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OIO75_RS14760	COG1280	lysine exporter protein (LysE YggA)
OIO75_RS14765	COG2267	carboxylic ester hydrolase activity
OIO75_RS14775	COG0019	diaminopimelate decarboxylase activity
OIO75_RS14785	COG1113	amino acid transport
OIO75_RS14800	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
OIO75_RS14810	COG3339	Conserved Protein
OIO75_RS14815	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OIO75_RS14820	COG0243	molybdopterin cofactor binding
OIO75_RS14825	COG1929	Belongs to the glycerate kinase type-1 family
OIO75_RS14840	COG0778	Nitroreductase
OIO75_RS14865	COG3811	Belongs to the UPF0386 family
OIO75_RS14890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO75_RS14905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OIO75_RS14925	COG0741	lytic transglycosylase activity
OIO75_RS14945	COG0584	glycerophosphoryl diester phosphodiesterase
OIO75_RS14950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OIO75_RS14975	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
OIO75_RS14980	COG1597	lipid kinase activity
OIO75_RS14995	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OIO75_RS15000	COG0477	Major facilitator Superfamily
OIO75_RS15050	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OIO75_RS15055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OIO75_RS15080	COG0505	Belongs to the CarA family
OIO75_RS15100	COG0589	response to stress
OIO75_RS15115	COG2843	Capsule synthesis protein
OIO75_RS15135	COG2321	neutral zinc metallopeptidase
OIO75_RS15140	COG2354	Protein conserved in bacteria
OIO75_RS15160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OIO75_RS15185	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OIO75_RS15190	COG1053	succinate dehydrogenase
OIO75_RS15195	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
OIO75_RS15200	COG2009	succinate dehydrogenase
OIO75_RS15235	COG2921	Belongs to the UPF0250 family
OIO75_RS15240	COG0321	lipoyl(octanoyl) transferase activity
OIO75_RS15255	COG0531	amino acid
OIO75_RS15265	COG1733	regulation of RNA biosynthetic process
OIO75_RS15270	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OIO75_RS15275	COG1648	precorrin-2 dehydrogenase activity
OIO75_RS15275	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OIO75_RS15290	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
OIO75_RS15325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO75_RS15335	COG1538	Outer membrane efflux protein
OIO75_RS15340	COG0393	Putative heavy-metal-binding
OIO75_RS15345	COG0393	Putative heavy-metal-binding
OIO75_RS15355	COG1028	Short-chain dehydrogenase reductase Sdr
OIO75_RS15365	COG0525	valine-tRNA ligase activity
OIO75_RS15385	COG0583	DNA-binding transcription factor activity
OIO75_RS15390	COG0004	ammonium transporteR
OIO75_RS15405	COG0642	Histidine kinase
OIO75_RS15410	COG0745	RESPONSE REGULATOR receiver
OIO75_RS15415	COG2194	sulfuric ester hydrolase activity
OIO75_RS15435	COG1752	Esterase of the alpha-beta hydrolase superfamily
OIO75_RS15450	COG2315	Protein conserved in bacteria
OIO75_RS15455	COG0142	geranyltranstransferase activity
OIO75_RS15460	COG2828	Protein conserved in bacteria
OIO75_RS15465	COG1113	amino acid transport
OIO75_RS15510	COG2207	Transcriptional regulator
OIO75_RS15535	COG2249	NAD(P)H dehydrogenase (quinone) activity
OIO75_RS15545	COG0560	Phosphoserine phosphatase
OIO75_RS15555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO75_RS15565	COG1530	ribonuclease E activity
OIO75_RS15570	COG0424	maF-like protein
OIO75_RS15575	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
OIO75_RS15580	COG1792	Involved in formation and maintenance of cell shape
OIO75_RS15585	COG1077	Cell shape determining protein MreB Mrl
OIO75_RS15590	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OIO75_RS15600	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OIO75_RS15625	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
OIO75_RS15630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OIO75_RS15635	COG1752	Esterase of the alpha-beta hydrolase superfamily
OIO75_RS15640	COG1115	amino acid carrier protein
OIO75_RS15660	COG2814	Major facilitator Superfamily
OIO75_RS15665	COG1289	transmembrane transporter activity
OIO75_RS15675	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OIO75_RS15725	COG1376	ErfK ybiS ycfS ynhG family protein
OIO75_RS15730	COG2832	Protein of unknown function (DUF454)
OIO75_RS15740	COG5510	response to toxic substance
OIO75_RS15765	COG0840	transmembrane signaling receptor activity
OIO75_RS15805	COG3422	double-strand break repair
OIO75_RS15810	COG2824	Alkylphosphonate utilization operon protein PhnA
OIO75_RS15815	COG3189	MarR family transcriptional regulator
OIO75_RS15825	COG0354	folic acid binding
OIO75_RS15830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OIO75_RS15840	COG0679	Auxin Efflux Carrier
OIO75_RS15845	COG1902	pentaerythritol trinitrate reductase activity
OIO75_RS15850	COG4772	TonB-dependent receptor
OIO75_RS15855	COG2094	Belongs to the DNA glycosylase MPG family
OIO75_RS15880	COG1217	gtp-binding protein TYPA
OIO75_RS15885	COG2233	PERMEase
OIO75_RS15895	COG0833	amino acid
OIO75_RS15900	COG1690	Belongs to the RtcB family
OIO75_RS15910	COG2885	chlorophyll binding
OIO75_RS15910	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
OIO75_RS15920	COG0183	Belongs to the thiolase family
OIO75_RS15940	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO75_RS15960	COG2207	Transcriptional regulator
OIO75_RS15965	COG0183	Belongs to the thiolase family
OIO75_RS15995	COG1272	protein, Hemolysin III
OIO75_RS16000	COG0477	Major facilitator Superfamily
OIO75_RS16015	COG0450	alkyl hydroperoxide reductase
OIO75_RS16035	COG0285	dihydrofolate synthase activity
OIO75_RS16085	COG2096	Adenosyltransferase
OIO75_RS16090	COG0584	glycerophosphoryl diester phosphodiesterase
OIO75_RS16105	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
OIO75_RS16110	COG0745	RESPONSE REGULATOR receiver
OIO75_RS16115	COG2205	protein histidine kinase activity
OIO75_RS16125	COG1960	acyl-CoA dehydrogenase activity
OIO75_RS16130	COG1960	acyl-CoA dehydrogenase activity
OIO75_RS16195	COG0438	transferase activity, transferring glycosyl groups
OIO75_RS16200	COG0463	Glycosyl transferase, family 2
OIO75_RS16205	COG0726	polysaccharide deacetylase
OIO75_RS16225	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
OIO75_RS16230	COG2205	protein histidine kinase activity
OIO75_RS16260	COG1862	Preprotein translocase
OIO75_RS16270	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OIO75_RS16275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OIO75_RS16285	COG3781	membrane
OIO75_RS16290	COG0613	PHP domain protein
OIO75_RS16300	COG2350	Protein conserved in bacteria
OIO75_RS16330	COG1607	acyl-coa hydrolase
OIO75_RS16390	COG2199	diguanylate cyclase activity
OIO75_RS16400	COG1408	metallophosphoesterase
OIO75_RS16405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OIO75_RS16415	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OIO75_RS16435	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OIO75_RS16440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OIO75_RS16445	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
OIO75_RS16455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OIO75_RS16465	COG2969	positive regulation of protein catabolic process
OIO75_RS16485	COG1960	acyl-CoA dehydrogenase activity
OIO75_RS16490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OIO75_RS16505	COG1309	transcriptional regulator
OIO75_RS16510	COG1960	acyl-CoA dehydrogenase activity
OIO75_RS16555	COG1183	phosphatidylcholine synthase activity
OIO75_RS16560	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
OIO75_RS16590	COG0741	lytic transglycosylase activity
OIO75_RS16590	COG1196	nuclear chromosome segregation
OIO75_RS16590	COG0739	heme binding
OIO75_RS16600	COG1702	phosphate starvation-inducible protein PhoH
OIO75_RS16635	COG1295	ribonuclease BN
OIO75_RS16640	COG0697	spore germination
OIO75_RS16645	COG2169	Transcriptional regulator
OIO75_RS16650	COG0179	Fumarylacetoacetate (FAA) hydrolase
OIO75_RS16690	COG0557	exoribonuclease II activity
OIO75_RS16695	COG0339	signal peptide processing
OIO75_RS16700	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
OIO75_RS16730	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
OIO75_RS16735	COG1960	acyl-CoA dehydrogenase activity
OIO75_RS16900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO75_RS16900	COG1017	nitric oxide dioxygenase activity
OIO75_RS16905	COG1959	2 iron, 2 sulfur cluster binding
OIO75_RS16920	COG1301	dicarboxylic acid transport
OIO75_RS16925	COG1946	Acyl-CoA thioesterase
OIO75_RS16945	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OIO75_RS16950	COG1040	competence protein
OIO75_RS16955	COG0494	nUDIX hydrolase
OIO75_RS16965	COG0598	Magnesium transport protein CorA
OIO75_RS16975	COG2854	intermembrane phospholipid transfer
OIO75_RS16985	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OIO75_RS16990	COG1127	ABC transporter
OIO75_RS17000	COG0513	Belongs to the DEAD box helicase family
OIO75_RS17020	COG0408	coproporphyrinogen oxidase activity
OIO75_RS17035	COG1960	acyl-CoA dehydrogenase activity
OIO75_RS17045	COG1983	PspC domain protein
OIO75_RS17050	COG0517	IMP dehydrogenase activity
OIO75_RS17075	COG0752	glycyl-tRNA synthetase alpha subunit
OIO75_RS17100	COG0583	DNA-binding transcription factor activity
OIO75_RS17140	COG1012	belongs to the aldehyde dehydrogenase family
OIO75_RS17150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OIO75_RS17155	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
OIO75_RS17160	COG0833	amino acid
OIO75_RS17190	COG1192	Involved in chromosome partitioning
OIO75_RS17195	COG0628	permease
OIO75_RS17205	COG1289	transmembrane transporter activity
OIO75_RS17220	COG2249	NAD(P)H dehydrogenase (quinone) activity
OIO75_RS17225	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
OIO75_RS17235	COG0277	FAD linked oxidase domain protein
OIO75_RS17240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OIO75_RS17265	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
OIO75_RS17270	COG5380	lipid catabolic process
OIO75_RS17290	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OIO75_RS17345	COG0194	GDP metabolic process
OIO75_RS17360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OIO75_RS17380	COG3307	-O-antigen
OIO75_RS17395	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
OIO75_RS17400	COG1704	LemA family
OIO75_RS17410	COG0493	'glutamate synthase
OIO75_RS17415	COG0070	glutamate synthase
OIO75_RS17415	COG0069	glutamate synthase activity
OIO75_RS17415	COG0067	glutamate synthase
OIO75_RS17465	COG2226	methyltransferase
OIO75_RS17480	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OIO75_RS17485	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OIO75_RS17530	COG0833	amino acid
OIO75_RS17595	COG0488	(ABC) transporter
OIO75_RS17600	COG2873	o-acetylhomoserine
OIO75_RS17605	COG4221	oxidoreductase activity
OIO75_RS17610	COG0659	secondary active sulfate transmembrane transporter activity
OIO75_RS17635	COG0427	acetyl-CoA hydrolase
OIO75_RS17665	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
OIO75_RS17685	COG1132	(ABC) transporter
OIO75_RS17700	COG2329	Antibiotic biosynthesis monooxygenase
OIO75_RS17715	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
OIO75_RS17780	COG2249	NAD(P)H dehydrogenase (quinone) activity
OIO75_RS17785	COG1733	regulation of RNA biosynthetic process
OIO75_RS17820	COG0667	Aldo Keto reductase
OIO75_RS17840	COG1309	transcriptional regulator
OIO75_RS17855	COG0583	DNA-binding transcription factor activity
OIO75_RS17860	COG2814	Major facilitator Superfamily
OIO75_RS17895	COG1335	isochorismatase
OIO75_RS17905	COG1012	belongs to the aldehyde dehydrogenase family
OIO75_RS17910	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OIO75_RS17920	COG1113	amino acid transport
OIO75_RS17930	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
OIO75_RS17975	COG2814	Major facilitator Superfamily
OIO75_RS17985	COG0352	thiamine-phosphate diphosphorylase activity
OIO75_RS17985	COG0351	phosphomethylpyrimidine kinase
OIO75_RS17985	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OIO75_RS18005	COG1309	transcriptional regulator
OIO75_RS18010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OIO75_RS18030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OIO75_RS18040	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OIO75_RS18045	COG3162	membrane
OIO75_RS18050	COG0784	Response regulator, receiver
OIO75_RS18050	COG2205	protein histidine kinase activity
OIO75_RS18050	COG2198	Histidine kinase
OIO75_RS18075	COG1522	sequence-specific DNA binding
OIO75_RS18080	COG1335	isochorismatase
OIO75_RS18085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OIO75_RS18095	COG0668	transmembrane transport
OIO75_RS18100	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OIO75_RS18105	COG1519	Transferase
OIO75_RS18110	COG1902	pentaerythritol trinitrate reductase activity
OIO75_RS18135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OIO75_RS18160	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO75_RS18160	COG0426	domain, Protein
OIO75_RS18165	COG4774	siderophore transport
OIO75_RS18170	COG2119	membrane
OIO75_RS18180	COG0508	dehydrogenase complex catalyzes the overall conversion of
OIO75_RS18190	COG4942	peptidase
OIO75_RS18205	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OIO75_RS18215	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
OIO75_RS18235	COG0189	ligase activity
OIO75_RS18255	COG0708	Exodeoxyribonuclease III
OIO75_RS18260	COG1393	Belongs to the ArsC family
OIO75_RS18275	COG3706	GGDEF domain
OIO75_RS18310	COG2351	hydroxyisourate hydrolase activity
OIO75_RS18315	COG2233	PERMEase
OIO75_RS18325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO75_RS18335	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
OIO75_RS18345	COG3150	esterase
OIO75_RS18370	COG2918	glutathione biosynthetic process
OIO75_RS18385	COG2733	membrane
OIO75_RS18390	COG0436	Aminotransferase
OIO75_RS18395	COG0534	Mate efflux family protein
OIO75_RS18480	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
OIO75_RS18485	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
OIO75_RS18495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OIO75_RS18520	COG1280	lysine exporter protein (LysE YggA)
OIO75_RS18540	COG0010	Belongs to the arginase family
OIO75_RS18570	COG2188	Transcriptional regulator
OIO75_RS18580	COG0523	cobalamin synthesis protein
OIO75_RS18590	COG1113	amino acid transport
OIO75_RS18600	COG0625	glutathione transferase activity
OIO75_RS18620	COG1683	Conserved Protein
OIO75_RS18625	COG0534	Mate efflux family protein
OIO75_RS18630	COG0385	Bile acid
OIO75_RS18635	COG1335	isochorismatase
OIO75_RS18640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OIO75_RS18660	COG2116	formate transmembrane transporter activity
OIO75_RS18665	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OIO75_RS18680	COG3188	usher protein
OIO75_RS18685	COG3121	Chaperone
OIO75_RS18695	COG2983	Belongs to the UPF0260 family
OIO75_RS18715	COG1194	a g-specific adenine glycosylase
OIO75_RS18730	COG2818	Glycosylase
OIO75_RS18735	COG1064	alcohol dehydrogenase
OIO75_RS18740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO75_RS18755	COG0583	DNA-binding transcription factor activity
OIO75_RS18760	COG0656	L-ascorbic acid biosynthetic process
OIO75_RS18765	COG2814	Major facilitator Superfamily
OIO75_RS18800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO75_RS18815	COG2233	PERMEase
OIO75_RS18855	COG0733	neurotransmitter:sodium symporter activity
OIO75_RS18895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OIO75_RS18900	COG0657	acetylesterase activity
OIO75_RS18920	COG0583	DNA-binding transcription factor activity
OIO75_RS18950	COG2951	lytic endotransglycosylase activity
OIO75_RS18955	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
OIO75_RS18970	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OIO75_RS18980	COG0671	phosphoesterase, PA-phosphatase related
OIO75_RS18985	COG0861	Integral membrane protein TerC family
OIO75_RS18995	COG0754	glutathionylspermidine amidase activity
OIO75_RS19005	COG0402	S-adenosylhomocysteine deaminase activity
OIO75_RS19020	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OIO75_RS19025	COG1230	cation diffusion facilitator family transporter
OIO75_RS19040	COG0706	membrane insertase activity
OIO75_RS19060	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
OIO75_RS19175	COG4683	PFAM Phage derived protein Gp49-like (DUF891)