locus-tag	class	description
OIO85_RS00010	COG0592	DNA-directed DNA polymerase activity
OIO85_RS00020	COG0187	DNA topoisomerase II activity
OIO85_RS00030	COG0586	Pfam SNARE associated Golgi protein
OIO85_RS00035	COG0488	(ABC) transporter
OIO85_RS00060	COG0596	Alpha beta hydrolase
OIO85_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
OIO85_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OIO85_RS00110	COG0733	neurotransmitter:sodium symporter activity
OIO85_RS00150	COG2233	PERMEase
OIO85_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO85_RS00200	COG2814	Major facilitator Superfamily
OIO85_RS00205	COG0656	L-ascorbic acid biosynthetic process
OIO85_RS00210	COG0583	DNA-binding transcription factor activity
OIO85_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO85_RS00230	COG1064	alcohol dehydrogenase
OIO85_RS00235	COG2818	Glycosylase
OIO85_RS00250	COG1194	a g-specific adenine glycosylase
OIO85_RS00270	COG2983	Belongs to the UPF0260 family
OIO85_RS00290	COG3188	usher protein
OIO85_RS00305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OIO85_RS00310	COG2116	formate transmembrane transporter activity
OIO85_RS00330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OIO85_RS00335	COG1335	isochorismatase
OIO85_RS00340	COG0385	Bile acid
OIO85_RS00345	COG0534	Mate efflux family protein
OIO85_RS00350	COG1683	Conserved Protein
OIO85_RS00370	COG0625	glutathione transferase activity
OIO85_RS00380	COG1113	amino acid transport
OIO85_RS00390	COG0523	cobalamin synthesis protein
OIO85_RS00400	COG2188	Transcriptional regulator
OIO85_RS00430	COG0010	Belongs to the arginase family
OIO85_RS00450	COG1280	lysine exporter protein (LysE YggA)
OIO85_RS00475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OIO85_RS00485	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
OIO85_RS00490	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
OIO85_RS00575	COG0534	Mate efflux family protein
OIO85_RS00580	COG0436	Aminotransferase
OIO85_RS00585	COG2733	membrane
OIO85_RS00600	COG2918	glutathione biosynthetic process
OIO85_RS00625	COG3150	esterase
OIO85_RS00635	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
OIO85_RS00645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO85_RS00655	COG2233	PERMEase
OIO85_RS00660	COG2351	hydroxyisourate hydrolase activity
OIO85_RS00695	COG3706	GGDEF domain
OIO85_RS00710	COG1393	Belongs to the ArsC family
OIO85_RS00715	COG0708	Exodeoxyribonuclease III
OIO85_RS00735	COG0189	ligase activity
OIO85_RS00755	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
OIO85_RS00765	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OIO85_RS00780	COG4942	peptidase
OIO85_RS00790	COG0508	dehydrogenase complex catalyzes the overall conversion of
OIO85_RS00800	COG2119	membrane
OIO85_RS00805	COG4774	siderophore transport
OIO85_RS00810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO85_RS00810	COG0426	domain, Protein
OIO85_RS00835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OIO85_RS00860	COG1902	pentaerythritol trinitrate reductase activity
OIO85_RS00865	COG1519	Transferase
OIO85_RS00870	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OIO85_RS00875	COG0668	transmembrane transport
OIO85_RS00885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OIO85_RS00890	COG1335	isochorismatase
OIO85_RS00895	COG1522	sequence-specific DNA binding
OIO85_RS00920	COG0784	Response regulator, receiver
OIO85_RS00920	COG2205	protein histidine kinase activity
OIO85_RS00920	COG2198	Histidine kinase
OIO85_RS00925	COG3162	membrane
OIO85_RS00930	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OIO85_RS00940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OIO85_RS00960	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OIO85_RS00965	COG1309	transcriptional regulator
OIO85_RS00985	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OIO85_RS00985	COG0352	thiamine-phosphate diphosphorylase activity
OIO85_RS00985	COG0351	phosphomethylpyrimidine kinase
OIO85_RS00995	COG2814	Major facilitator Superfamily
OIO85_RS01035	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
OIO85_RS01045	COG1113	amino acid transport
OIO85_RS01055	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OIO85_RS01060	COG1012	belongs to the aldehyde dehydrogenase family
OIO85_RS01070	COG1335	isochorismatase
OIO85_RS01105	COG2814	Major facilitator Superfamily
OIO85_RS01110	COG0583	DNA-binding transcription factor activity
OIO85_RS01125	COG1309	transcriptional regulator
OIO85_RS01145	COG0667	Aldo Keto reductase
OIO85_RS01180	COG1733	regulation of RNA biosynthetic process
OIO85_RS01185	COG2249	NAD(P)H dehydrogenase (quinone) activity
OIO85_RS01250	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
OIO85_RS01265	COG2329	Antibiotic biosynthesis monooxygenase
OIO85_RS01280	COG1132	(ABC) transporter
OIO85_RS01300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
OIO85_RS01330	COG0427	acetyl-CoA hydrolase
OIO85_RS01355	COG0659	secondary active sulfate transmembrane transporter activity
OIO85_RS01360	COG4221	oxidoreductase activity
OIO85_RS01365	COG2873	o-acetylhomoserine
OIO85_RS01370	COG0488	(ABC) transporter
OIO85_RS01435	COG0833	amino acid
OIO85_RS01480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OIO85_RS01485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OIO85_RS01500	COG2226	methyltransferase
OIO85_RS01550	COG0070	glutamate synthase
OIO85_RS01550	COG0069	glutamate synthase activity
OIO85_RS01550	COG0067	glutamate synthase
OIO85_RS01555	COG0493	'glutamate synthase
OIO85_RS01565	COG1704	LemA family
OIO85_RS01570	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
OIO85_RS01585	COG3307	-O-antigen
OIO85_RS01605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OIO85_RS01620	COG0194	GDP metabolic process
OIO85_RS01675	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OIO85_RS01695	COG5380	lipid catabolic process
OIO85_RS01700	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
OIO85_RS01725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OIO85_RS01730	COG0277	FAD linked oxidase domain protein
OIO85_RS01740	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
OIO85_RS01745	COG2249	NAD(P)H dehydrogenase (quinone) activity
OIO85_RS01760	COG1289	transmembrane transporter activity
OIO85_RS01770	COG0628	permease
OIO85_RS01775	COG1192	Involved in chromosome partitioning
OIO85_RS01805	COG0833	amino acid
OIO85_RS01815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OIO85_RS01825	COG1012	belongs to the aldehyde dehydrogenase family
OIO85_RS01865	COG0583	DNA-binding transcription factor activity
OIO85_RS01890	COG0752	glycyl-tRNA synthetase alpha subunit
OIO85_RS01915	COG0517	IMP dehydrogenase activity
OIO85_RS01920	COG1983	PspC domain protein
OIO85_RS01930	COG1960	acyl-CoA dehydrogenase activity
OIO85_RS01945	COG0408	coproporphyrinogen oxidase activity
OIO85_RS01965	COG0513	Belongs to the DEAD box helicase family
OIO85_RS01975	COG1127	ABC transporter
OIO85_RS01980	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OIO85_RS01990	COG2854	intermembrane phospholipid transfer
OIO85_RS02000	COG0598	Magnesium transport protein CorA
OIO85_RS02010	COG0494	nUDIX hydrolase
OIO85_RS02015	COG1040	competence protein
OIO85_RS02020	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OIO85_RS02040	COG1946	Acyl-CoA thioesterase
OIO85_RS02045	COG1301	dicarboxylic acid transport
OIO85_RS02060	COG1959	2 iron, 2 sulfur cluster binding
OIO85_RS02065	COG1017	nitric oxide dioxygenase activity
OIO85_RS02065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO85_RS02230	COG1960	acyl-CoA dehydrogenase activity
OIO85_RS02235	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
OIO85_RS02265	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
OIO85_RS02270	COG0339	signal peptide processing
OIO85_RS02275	COG0557	exoribonuclease II activity
OIO85_RS02320	COG0179	Fumarylacetoacetate (FAA) hydrolase
OIO85_RS02325	COG2169	Transcriptional regulator
OIO85_RS02330	COG0697	spore germination
OIO85_RS02335	COG1295	ribonuclease BN
OIO85_RS02370	COG1702	phosphate starvation-inducible protein PhoH
OIO85_RS02380	COG0739	heme binding
OIO85_RS02380	COG0741	lytic transglycosylase activity
OIO85_RS02380	COG1196	nuclear chromosome segregation
OIO85_RS02410	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
OIO85_RS02415	COG1183	phosphatidylcholine synthase activity
OIO85_RS02460	COG1960	acyl-CoA dehydrogenase activity
OIO85_RS02465	COG1309	transcriptional regulator
OIO85_RS02480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OIO85_RS02485	COG1960	acyl-CoA dehydrogenase activity
OIO85_RS02505	COG2969	positive regulation of protein catabolic process
OIO85_RS02515	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OIO85_RS02525	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
OIO85_RS02530	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OIO85_RS02535	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OIO85_RS02555	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OIO85_RS02565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OIO85_RS02570	COG1408	metallophosphoesterase
OIO85_RS02580	COG2199	diguanylate cyclase activity
OIO85_RS02640	COG1607	acyl-coa hydrolase
OIO85_RS02670	COG2350	Protein conserved in bacteria
OIO85_RS02680	COG0613	PHP domain protein
OIO85_RS02685	COG3781	membrane
OIO85_RS02695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OIO85_RS02700	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OIO85_RS02710	COG1862	Preprotein translocase
OIO85_RS02740	COG2205	protein histidine kinase activity
OIO85_RS02745	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
OIO85_RS02765	COG0726	polysaccharide deacetylase
OIO85_RS02770	COG0463	Glycosyl transferase, family 2
OIO85_RS02775	COG0438	transferase activity, transferring glycosyl groups
OIO85_RS02840	COG1960	acyl-CoA dehydrogenase activity
OIO85_RS02845	COG1960	acyl-CoA dehydrogenase activity
OIO85_RS02855	COG2205	protein histidine kinase activity
OIO85_RS02860	COG0745	RESPONSE REGULATOR receiver
OIO85_RS02865	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
OIO85_RS02880	COG0584	glycerophosphoryl diester phosphodiesterase
OIO85_RS02885	COG2096	Adenosyltransferase
OIO85_RS02935	COG0285	dihydrofolate synthase activity
OIO85_RS02955	COG0450	alkyl hydroperoxide reductase
OIO85_RS02970	COG0477	Major facilitator Superfamily
OIO85_RS02975	COG1272	protein, Hemolysin III
OIO85_RS03005	COG0183	Belongs to the thiolase family
OIO85_RS03010	COG2207	Transcriptional regulator
OIO85_RS03030	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO85_RS03050	COG0183	Belongs to the thiolase family
OIO85_RS03060	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
OIO85_RS03060	COG2885	chlorophyll binding
OIO85_RS03070	COG1690	Belongs to the RtcB family
OIO85_RS03075	COG0833	amino acid
OIO85_RS03085	COG2233	PERMEase
OIO85_RS03090	COG1217	gtp-binding protein TYPA
OIO85_RS03115	COG2094	Belongs to the DNA glycosylase MPG family
OIO85_RS03120	COG4772	TonB-dependent receptor
OIO85_RS03125	COG1902	pentaerythritol trinitrate reductase activity
OIO85_RS03140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OIO85_RS03145	COG0354	folic acid binding
OIO85_RS03155	COG3189	MarR family transcriptional regulator
OIO85_RS03160	COG2824	Alkylphosphonate utilization operon protein PhnA
OIO85_RS03165	COG3422	double-strand break repair
OIO85_RS03205	COG0840	transmembrane signaling receptor activity
OIO85_RS03230	COG5510	response to toxic substance
OIO85_RS03240	COG2832	Protein of unknown function (DUF454)
OIO85_RS03245	COG1376	ErfK ybiS ycfS ynhG family protein
OIO85_RS03295	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OIO85_RS03305	COG1289	transmembrane transporter activity
OIO85_RS03310	COG2814	Major facilitator Superfamily
OIO85_RS03330	COG1115	amino acid carrier protein
OIO85_RS03335	COG1752	Esterase of the alpha-beta hydrolase superfamily
OIO85_RS03340	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OIO85_RS03345	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
OIO85_RS03375	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OIO85_RS03385	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OIO85_RS03390	COG1077	Cell shape determining protein MreB Mrl
OIO85_RS03395	COG1792	Involved in formation and maintenance of cell shape
OIO85_RS03400	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
OIO85_RS03405	COG0424	maF-like protein
OIO85_RS03410	COG1530	ribonuclease E activity
OIO85_RS03420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO85_RS03430	COG0560	Phosphoserine phosphatase
OIO85_RS03440	COG2249	NAD(P)H dehydrogenase (quinone) activity
OIO85_RS03465	COG2207	Transcriptional regulator
OIO85_RS03510	COG1113	amino acid transport
OIO85_RS03515	COG2828	Protein conserved in bacteria
OIO85_RS03520	COG0142	geranyltranstransferase activity
OIO85_RS03525	COG2315	Protein conserved in bacteria
OIO85_RS03540	COG1752	Esterase of the alpha-beta hydrolase superfamily
OIO85_RS03560	COG2194	sulfuric ester hydrolase activity
OIO85_RS03565	COG0745	RESPONSE REGULATOR receiver
OIO85_RS03570	COG0642	Histidine kinase
OIO85_RS03585	COG0004	ammonium transporteR
OIO85_RS03590	COG0583	DNA-binding transcription factor activity
OIO85_RS03610	COG0525	valine-tRNA ligase activity
OIO85_RS03620	COG1028	Short-chain dehydrogenase reductase Sdr
OIO85_RS03630	COG0393	Putative heavy-metal-binding
OIO85_RS03635	COG0393	Putative heavy-metal-binding
OIO85_RS03640	COG1538	Outer membrane efflux protein
OIO85_RS03650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO85_RS03685	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
OIO85_RS03700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OIO85_RS03700	COG1648	precorrin-2 dehydrogenase activity
OIO85_RS03705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OIO85_RS03710	COG1733	regulation of RNA biosynthetic process
OIO85_RS03720	COG0531	amino acid
OIO85_RS03735	COG0321	lipoyl(octanoyl) transferase activity
OIO85_RS03740	COG2921	Belongs to the UPF0250 family
OIO85_RS03775	COG2009	succinate dehydrogenase
OIO85_RS03780	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
OIO85_RS03785	COG1053	succinate dehydrogenase
OIO85_RS03790	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OIO85_RS03815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OIO85_RS03835	COG2354	Protein conserved in bacteria
OIO85_RS03840	COG2321	neutral zinc metallopeptidase
OIO85_RS03860	COG2843	Capsule synthesis protein
OIO85_RS03875	COG0589	response to stress
OIO85_RS03895	COG0505	Belongs to the CarA family
OIO85_RS03920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OIO85_RS03925	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OIO85_RS03975	COG0477	Major facilitator Superfamily
OIO85_RS03980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OIO85_RS03995	COG1597	lipid kinase activity
OIO85_RS04000	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
OIO85_RS04025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OIO85_RS04030	COG0584	glycerophosphoryl diester phosphodiesterase
OIO85_RS04050	COG0741	lytic transglycosylase activity
OIO85_RS04070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OIO85_RS04085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO85_RS04110	COG3811	Belongs to the UPF0386 family
OIO85_RS04135	COG0778	Nitroreductase
OIO85_RS04150	COG1929	Belongs to the glycerate kinase type-1 family
OIO85_RS04155	COG0243	molybdopterin cofactor binding
OIO85_RS04160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OIO85_RS04165	COG3339	Conserved Protein
OIO85_RS04175	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
OIO85_RS04190	COG1113	amino acid transport
OIO85_RS04200	COG0019	diaminopimelate decarboxylase activity
OIO85_RS04210	COG2267	carboxylic ester hydrolase activity
OIO85_RS04215	COG1280	lysine exporter protein (LysE YggA)
OIO85_RS04220	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OIO85_RS04250	COG0463	Glycosyl transferase, family 2
OIO85_RS04270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO85_RS04305	COG4591	ABC-type transport system involved in lipoprotein release permease component
OIO85_RS04310	COG1136	(ABC) transporter
OIO85_RS04315	COG0658	competence protein
OIO85_RS04315	COG2333	competence protein COMEC
OIO85_RS04325	COG0616	signal peptide processing
OIO85_RS04325	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OIO85_RS04330	COG0596	Alpha beta hydrolase
OIO85_RS04335	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OIO85_RS04345	COG0628	permease
OIO85_RS04380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OIO85_RS04400	COG0823	Involved in the tonB-independent uptake of proteins
OIO85_RS04420	COG0824	Thioesterase
OIO85_RS04425	COG1473	amidohydrolase
OIO85_RS04445	COG0047	phosphoribosylformylglycinamidine synthase activity
OIO85_RS04445	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OIO85_RS04450	COG2814	Major facilitator Superfamily
OIO85_RS04465	COG1024	Enoyl-CoA hydratase
OIO85_RS04470	COG1051	belongs to the nudix hydrolase family
OIO85_RS04470	COG1056	cytidyltransferase-related domain
OIO85_RS04480	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
OIO85_RS04495	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
OIO85_RS04510	COG4625	pathogenesis
OIO85_RS04515	COG0583	DNA-binding transcription factor activity
OIO85_RS04520	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
OIO85_RS04525	COG4208	sulfate ABC transporter
OIO85_RS04530	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
OIO85_RS04540	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
OIO85_RS04545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OIO85_RS04550	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OIO85_RS04570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OIO85_RS04580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OIO85_RS04590	COG0681	Belongs to the peptidase S26 family
OIO85_RS04605	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
OIO85_RS04615	COG1381	Involved in DNA repair and RecF pathway recombination
OIO85_RS04620	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
OIO85_RS04630	COG4221	oxidoreductase activity
OIO85_RS04660	COG0443	Heat shock 70 kDa protein
OIO85_RS04670	COG0436	Aminotransferase
OIO85_RS04690	COG0556	nucleotide-excision repair
OIO85_RS04745	COG2070	2-Nitropropane dioxygenase
OIO85_RS04760	COG1252	NADH dehydrogenase
OIO85_RS04765	COG1686	Belongs to the peptidase S11 family
OIO85_RS04780	COG1187	pseudouridine synthase activity
OIO85_RS04975	COG4695	Portal protein
OIO85_RS05110	COG0582	viral genome integration into host DNA
OIO85_RS05135	COG0477	Major facilitator Superfamily
OIO85_RS05140	COG0583	DNA-binding transcription factor activity
OIO85_RS05145	COG1823	symporter activity
OIO85_RS05155	COG0612	Peptidase, M16
OIO85_RS05180	COG0352	thiamine-phosphate diphosphorylase activity
OIO85_RS05215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO85_RS05230	COG1309	transcriptional regulator
OIO85_RS05240	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OIO85_RS05245	COG0076	glutamate decarboxylase activity
OIO85_RS05255	COG1522	sequence-specific DNA binding
OIO85_RS05260	COG3961	Belongs to the TPP enzyme family
OIO85_RS05265	COG1113	amino acid transport
OIO85_RS05270	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OIO85_RS05275	COG0573	inorganic phosphate transmembrane transporter activity
OIO85_RS05285	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OIO85_RS05290	COG0616	signal peptide processing
OIO85_RS05325	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
OIO85_RS05330	COG1686	Belongs to the peptidase S11 family
OIO85_RS05355	COG0583	DNA-binding transcription factor activity
OIO85_RS05360	COG1067	ATP-dependent peptidase activity
OIO85_RS05385	COG4943	cyclic-guanylate-specific phosphodiesterase activity
OIO85_RS05410	COG1966	Carbon starvation protein
OIO85_RS05415	COG2879	small protein
OIO85_RS05455	COG1335	isochorismatase
OIO85_RS05460	COG0583	DNA-binding transcription factor activity
OIO85_RS05475	COG0596	Alpha beta hydrolase
OIO85_RS05485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OIO85_RS05495	COG2130	NADP-dependent
OIO85_RS05525	COG1741	Belongs to the pirin family
OIO85_RS05535	COG2964	Protein conserved in bacteria
OIO85_RS05550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO85_RS05560	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OIO85_RS05565	COG4605	iron ion homeostasis
OIO85_RS05570	COG4604	ABC transporter, ATP-binding protein
OIO85_RS05575	COG4607	ABC-type enterochelin transport system periplasmic component
OIO85_RS05580	COG4774	siderophore transport
OIO85_RS05590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO85_RS05595	COG1021	2,3-dihydroxybenzoate-AMP ligase
OIO85_RS05600	COG3433	isochorismatase activity
OIO85_RS05600	COG1535	isochorismatase
OIO85_RS05615	COG1132	(ABC) transporter
OIO85_RS05620	COG1132	(ABC) transporter
OIO85_RS05625	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
OIO85_RS05630	COG2977	Belongs to the P-Pant transferase superfamily
OIO85_RS05650	COG3739	integral membrane protein
OIO85_RS05670	COG0302	gtp cyclohydrolase
OIO85_RS05680	COG1529	Aldehyde oxidase and xanthine dehydrogenase
OIO85_RS05710	COG0308	aminopeptidase N
OIO85_RS05715	COG0512	Glutamine amidotransferase of anthranilate synthase
OIO85_RS05730	COG0174	glutamine synthetase
OIO85_RS05740	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
OIO85_RS05775	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OIO85_RS05780	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
OIO85_RS05785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OIO85_RS05805	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OIO85_RS05810	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
OIO85_RS05815	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
OIO85_RS05830	COG1960	acyl-CoA dehydrogenase activity
OIO85_RS05835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OIO85_RS05840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OIO85_RS05850	COG2223	nitrite transmembrane transporter activity
OIO85_RS05870	COG0024	Methionine aminopeptidase
OIO85_RS05875	COG0052	Belongs to the universal ribosomal protein uS2 family
OIO85_RS05890	COG2207	Transcriptional regulator
OIO85_RS05915	COG2951	lytic endotransglycosylase activity
OIO85_RS05920	COG0772	Belongs to the SEDS family
OIO85_RS05935	COG0842	Transport permease protein
OIO85_RS05940	COG1131	(ABC) transporter
OIO85_RS05985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO85_RS06000	COG4215	(ABC) transporter
OIO85_RS06005	COG4160	amino acid transport
OIO85_RS06010	COG4598	ABC transporter
OIO85_RS06020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OIO85_RS06025	COG0826	peptidase U32
OIO85_RS06030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO85_RS06045	COG1720	tRNA m6t6A37 methyltransferase activity
OIO85_RS06055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OIO85_RS06070	COG0642	Histidine kinase
OIO85_RS06080	COG0494	nUDIX hydrolase
OIO85_RS06090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OIO85_RS06095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OIO85_RS06100	COG3139	Protein of unknown function (DUF1315)
OIO85_RS06110	COG1301	dicarboxylic acid transport
OIO85_RS06115	COG1960	acyl-CoA dehydrogenase activity
OIO85_RS06120	COG2819	hydrolase of the alpha beta superfamily
OIO85_RS06130	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
OIO85_RS06140	COG2195	Cleaves the N-terminal amino acid of tripeptides
OIO85_RS06160	COG1690	Belongs to the RtcB family
OIO85_RS06165	COG1234	tRNA 3'-trailer cleavage
OIO85_RS06170	COG4650	regulator
OIO85_RS06200	COG2363	Small membrane protein
OIO85_RS06225	COG0513	Belongs to the DEAD box helicase family
OIO85_RS06235	COG0778	Nitroreductase
OIO85_RS06265	COG1286	toxin biosynthetic process
OIO85_RS06290	COG4783	chaperone-mediated protein folding
OIO85_RS06295	COG1610	YqeY-like protein
OIO85_RS06325	COG0515	serine threonine protein kinase
OIO85_RS06325	COG2815	serine threonine protein kinase
OIO85_RS06395	COG3111	PFAM Bacterial OB fold (BOF) protein
OIO85_RS06420	COG3243	poly(R)-hydroxyalkanoic acid synthase
OIO85_RS06425	COG0786	glutamate:sodium symporter activity
OIO85_RS06435	COG2186	Transcriptional regulator
OIO85_RS06445	COG0477	Major facilitator Superfamily
OIO85_RS06475	COG2995	paraquat-inducible protein a
OIO85_RS06480	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OIO85_RS06480	COG3008	intermembrane lipid transfer
OIO85_RS06490	COG1794	racemase activity, acting on amino acids and derivatives
OIO85_RS06520	COG1301	dicarboxylic acid transport
OIO85_RS06530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OIO85_RS06535	COG2011	ABC-type metal ion transport system permease component
OIO85_RS06540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OIO85_RS06545	COG1464	Belongs to the NlpA lipoprotein family
OIO85_RS06550	COG0151	Belongs to the GarS family
OIO85_RS06555	COG0138	bifunctional purine biosynthesis protein purh
OIO85_RS06560	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
OIO85_RS06590	COG2308	Evidence 4 Homologs of previously reported genes of
OIO85_RS06600	COG1305	Transglutaminase-like
OIO85_RS06610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OIO85_RS06615	COG0305	Participates in initiation and elongation during chromosome replication
OIO85_RS06640	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
OIO85_RS06650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OIO85_RS06655	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OIO85_RS06680	COG0726	polysaccharide deacetylase
OIO85_RS06680	COG1649	PFAM Uncharacterised BCR, COG1649
OIO85_RS06685	COG1215	transferase activity, transferring glycosyl groups
OIO85_RS06690	COG3658	cytochrome
OIO85_RS06700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OIO85_RS06715	COG0583	DNA-binding transcription factor activity
OIO85_RS06735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO85_RS06740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO85_RS06755	COG1960	acyl-CoA dehydrogenase activity
OIO85_RS06760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OIO85_RS06765	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO85_RS06780	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
OIO85_RS06790	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
OIO85_RS06795	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
OIO85_RS06810	COG0745	RESPONSE REGULATOR receiver
OIO85_RS06815	COG0174	glutamine synthetase
OIO85_RS06835	COG0729	surface antigen
OIO85_RS06860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OIO85_RS06865	COG2814	Major facilitator Superfamily
OIO85_RS06880	COG0583	DNA-binding transcription factor activity
OIO85_RS06895	COG1187	pseudouridine synthase activity
OIO85_RS06915	COG0802	atpase or kinase
OIO85_RS06920	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OIO85_RS06930	COG1923	regulation of RNA biosynthetic process
OIO85_RS06935	COG0697	spore germination
OIO85_RS06960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OIO85_RS06965	COG0519	Catalyzes the synthesis of GMP from XMP
OIO85_RS06965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OIO85_RS06970	COG4302	ethanolamine ammonia-lyase activity
OIO85_RS06975	COG4303	Ethanolamine ammonia lyase large subunit
OIO85_RS06980	COG0531	amino acid
OIO85_RS07000	COG1454	alcohol dehydrogenase
OIO85_RS07005	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OIO85_RS07015	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
OIO85_RS07035	COG0308	aminopeptidase N
OIO85_RS07055	COG1605	Chorismate mutase
OIO85_RS07075	COG1309	transcriptional regulator
OIO85_RS07085	COG0668	transmembrane transport
OIO85_RS07115	COG4773	Receptor
OIO85_RS07135	COG0488	(ABC) transporter
OIO85_RS07140	COG0589	response to stress
OIO85_RS07165	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
OIO85_RS07175	COG3135	benzoate transporter
OIO85_RS07180	COG1522	sequence-specific DNA binding
OIO85_RS07190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OIO85_RS07195	COG0583	DNA-binding transcription factor activity
OIO85_RS07205	COG0183	Belongs to the thiolase family
OIO85_RS07215	COG2030	dehydratase
OIO85_RS07220	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OIO85_RS07235	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OIO85_RS07250	COG0824	Thioesterase
OIO85_RS07255	COG1454	alcohol dehydrogenase
OIO85_RS07265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OIO85_RS07285	COG0069	glutamate synthase activity
OIO85_RS07305	COG2814	Major facilitator Superfamily
OIO85_RS07320	COG0511	ligase activity, forming carbon-carbon bonds
OIO85_RS07340	COG1116	anion transmembrane transporter activity
OIO85_RS07340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO85_RS07345	COG0745	RESPONSE REGULATOR receiver
OIO85_RS07355	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO85_RS07355	COG2146	nitrite reductase [NAD(P)H] activity
OIO85_RS07360	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO85_RS07365	COG0243	molybdopterin cofactor binding
OIO85_RS07375	COG0243	molybdopterin cofactor binding
OIO85_RS07395	COG0521	Mo-molybdopterin cofactor biosynthetic process
OIO85_RS07395	COG0315	cyclic pyranopterin monophosphate synthase activity
OIO85_RS07410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO85_RS07415	COG0697	spore germination
OIO85_RS07435	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
OIO85_RS07440	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OIO85_RS07495	COG2204	response regulator
OIO85_RS07500	COG3852	Histidine kinase
OIO85_RS07520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OIO85_RS07525	COG0575	Belongs to the CDS family
OIO85_RS07540	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OIO85_RS07560	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OIO85_RS07575	COG2137	regulation of response to DNA damage stimulus
OIO85_RS07585	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
OIO85_RS07590	COG1011	Hydrolase
OIO85_RS07615	COG1522	sequence-specific DNA binding
OIO85_RS07625	COG1113	amino acid transport
OIO85_RS07645	COG0659	secondary active sulfate transmembrane transporter activity
OIO85_RS07650	COG2135	peptidase activity
OIO85_RS07665	COG3300	MHYT domain
OIO85_RS07665	COG5001	Diguanylate cyclase
OIO85_RS07685	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
OIO85_RS07685	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OIO85_RS07685	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OIO85_RS07690	COG1105	Belongs to the carbohydrate kinase PfkB family
OIO85_RS07695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OIO85_RS07695	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OIO85_RS07725	COG0024	Methionine aminopeptidase
OIO85_RS07730	COG0583	DNA-binding transcription factor activity
OIO85_RS07740	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
OIO85_RS07745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OIO85_RS07750	COG0516	GMP reductase activity
OIO85_RS07750	COG0517	IMP dehydrogenase activity
OIO85_RS07775	COG0552	protein localization to endoplasmic reticulum
OIO85_RS07785	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
OIO85_RS07795	COG4890	Cyd operon protein YbgT
OIO85_RS07800	COG1294	oxidase, subunit
OIO85_RS07815	COG1585	Membrane protein implicated in regulation of membrane protease activity
OIO85_RS07825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OIO85_RS07830	COG4774	siderophore transport
OIO85_RS07845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OIO85_RS07850	COG0569	domain protein
OIO85_RS07855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OIO85_RS07885	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
OIO85_RS07890	COG0542	response to heat
OIO85_RS07900	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OIO85_RS07915	COG1902	pentaerythritol trinitrate reductase activity
OIO85_RS07915	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO85_RS07960	COG2323	membrane
OIO85_RS07965	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
OIO85_RS07975	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
OIO85_RS07980	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OIO85_RS07985	COG0183	Belongs to the thiolase family
OIO85_RS07990	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OIO85_RS07995	COG0596	Alpha beta hydrolase
OIO85_RS08000	COG2271	Major facilitator Superfamily
OIO85_RS08005	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OIO85_RS08010	COG3485	protocatechuate 3,4-dioxygenase
OIO85_RS08015	COG3485	protocatechuate 3,4-dioxygenase
OIO85_RS08020	COG0710	3-dehydroquinate dehydratase activity
OIO85_RS08025	COG3420	alginic acid biosynthetic process
OIO85_RS08030	COG3659	wide pore channel activity
OIO85_RS08035	COG4993	Dehydrogenase
OIO85_RS08045	COG2391	methyltransferase activity
OIO85_RS08060	COG1414	Transcriptional regulator
OIO85_RS08065	COG0583	DNA-binding transcription factor activity
OIO85_RS08070	COG1960	acyl-CoA dehydrogenase activity
OIO85_RS08095	COG2814	Major facilitator Superfamily
OIO85_RS08105	COG0154	amidase activity
OIO85_RS08125	COG4638	Rieske (2fe-2S)
OIO85_RS08135	COG1028	Short-chain dehydrogenase reductase Sdr
OIO85_RS08145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO85_RS08155	COG3733	amine oxidase
OIO85_RS08165	COG1012	belongs to the aldehyde dehydrogenase family
OIO85_RS08175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OIO85_RS08180	COG0183	Belongs to the thiolase family
OIO85_RS08185	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OIO85_RS08190	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
OIO85_RS08200	COG4829	muconolactone delta-isomerase
OIO85_RS08205	COG4948	Mandelate Racemase Muconate Lactonizing
OIO85_RS08210	COG0583	DNA-binding transcription factor activity
OIO85_RS08220	COG2186	Transcriptional regulator
OIO85_RS08240	COG1012	belongs to the aldehyde dehydrogenase family
OIO85_RS08245	COG3231	kanamycin kinase activity
OIO85_RS08260	COG1960	acyl-CoA dehydrogenase activity
OIO85_RS08265	COG1028	Short-chain dehydrogenase reductase Sdr
OIO85_RS08270	COG3829	transcription factor binding
OIO85_RS08280	COG3162	membrane
OIO85_RS08295	COG1012	belongs to the aldehyde dehydrogenase family
OIO85_RS08310	COG0753	catalase activity
OIO85_RS08335	COG1846	Transcriptional regulator
OIO85_RS08340	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO85_RS08340	COG1902	pentaerythritol trinitrate reductase activity
OIO85_RS08375	COG1309	transcriptional regulator
OIO85_RS08385	COG1335	isochorismatase
OIO85_RS08390	COG0583	DNA-binding transcription factor activity
OIO85_RS08400	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OIO85_RS08400	COG0475	glutathione-regulated potassium exporter activity
OIO85_RS08410	COG1473	amidohydrolase
OIO85_RS08465	COG2188	Transcriptional regulator
OIO85_RS08480	COG0583	DNA-binding transcription factor activity
OIO85_RS08515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OIO85_RS08535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OIO85_RS08555	COG1012	belongs to the aldehyde dehydrogenase family
OIO85_RS08570	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OIO85_RS08575	COG2814	Major facilitator Superfamily
OIO85_RS08585	COG0179	Fumarylacetoacetate (FAA) hydrolase
OIO85_RS08595	COG1012	belongs to the aldehyde dehydrogenase family
OIO85_RS08600	COG3384	dioxygenase
OIO85_RS08610	COG3971	2-oxopent-4-enoate hydratase activity
OIO85_RS08625	COG0477	Major facilitator Superfamily
OIO85_RS08630	COG1960	acyl-CoA dehydrogenase activity
OIO85_RS08635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO85_RS08640	COG1846	Transcriptional regulator
OIO85_RS08645	COG1012	belongs to the aldehyde dehydrogenase family
OIO85_RS08650	COG0129	dihydroxy-acid dehydratase activity
OIO85_RS08660	COG0583	DNA-binding transcription factor activity
OIO85_RS08665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OIO85_RS08675	COG2084	Dehydrogenase
OIO85_RS08680	COG2207	Transcriptional regulator
OIO85_RS08695	COG1064	alcohol dehydrogenase
OIO85_RS08705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OIO85_RS08710	COG1120	ATPase activity
OIO85_RS08730	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OIO85_RS08780	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
OIO85_RS08805	COG2814	Major facilitator Superfamily
OIO85_RS08810	COG3320	Male sterility
OIO85_RS08810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OIO85_RS08840	COG1028	Short-chain dehydrogenase reductase Sdr
OIO85_RS08850	COG2207	Transcriptional regulator
OIO85_RS08860	COG2205	protein histidine kinase activity
OIO85_RS08865	COG0745	RESPONSE REGULATOR receiver
OIO85_RS08870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO85_RS08875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OIO85_RS08900	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
OIO85_RS08910	COG0753	catalase activity
OIO85_RS08930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OIO85_RS08990	COG1535	isochorismatase
OIO85_RS08990	COG3433	isochorismatase activity
OIO85_RS08995	COG1028	Short-chain dehydrogenase reductase Sdr
OIO85_RS09000	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
OIO85_RS09005	COG4149	molybdate abc transporter
OIO85_RS09010	COG0725	ABC transporter, periplasmic molybdate-binding protein
OIO85_RS09020	COG4638	Rieske (2fe-2S)
OIO85_RS09025	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
OIO85_RS09030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO85_RS09030	COG0543	2 iron, 2 sulfur cluster binding
OIO85_RS09045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO85_RS09055	COG1028	Short-chain dehydrogenase reductase Sdr
OIO85_RS09070	COG2207	Transcriptional regulator
OIO85_RS09075	COG1028	Short-chain dehydrogenase reductase Sdr
OIO85_RS09080	COG2610	gluconate transmembrane transporter activity
OIO85_RS09090	COG0583	DNA-binding transcription factor activity
OIO85_RS09105	COG2031	fatty acid transporter
OIO85_RS09110	COG0183	Belongs to the thiolase family
OIO85_RS09115	COG0583	DNA-binding transcription factor activity
OIO85_RS09120	COG0583	DNA-binding transcription factor activity
OIO85_RS09135	COG1027	Aspartate ammonia-lyase
OIO85_RS09145	COG0477	Major facilitator Superfamily
OIO85_RS09165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO85_RS09170	COG4521	taurine ABC transporter
OIO85_RS09185	COG2188	Transcriptional regulator
OIO85_RS09195	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
OIO85_RS09200	COG1733	regulation of RNA biosynthetic process
OIO85_RS09205	COG3708	Transcriptional regulator
OIO85_RS09205	COG2207	Transcriptional regulator
OIO85_RS09220	COG0730	response to heat
OIO85_RS09235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OIO85_RS09235	COG3453	Protein conserved in bacteria
OIO85_RS09245	COG3781	membrane
OIO85_RS09250	COG1063	alcohol dehydrogenase
OIO85_RS09260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OIO85_RS09265	COG0508	dehydrogenase complex catalyzes the overall conversion of
OIO85_RS09270	COG0022	dehydrogenase e1 component
OIO85_RS09275	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
OIO85_RS09280	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OIO85_RS09295	COG3706	GGDEF domain
OIO85_RS09310	COG0133	tryptophan synthase activity
OIO85_RS09320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OIO85_RS09355	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OIO85_RS09380	COG2226	methyltransferase
OIO85_RS09435	COG0842	Transport permease protein
OIO85_RS09440	COG0842	Transport permease protein
OIO85_RS09445	COG1131	(ABC) transporter
OIO85_RS09460	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OIO85_RS09485	COG0730	response to heat
OIO85_RS09490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OIO85_RS09505	COG0406	alpha-ribazole phosphatase activity
OIO85_RS09510	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
OIO85_RS09525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OIO85_RS09555	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OIO85_RS09565	COG4264	IucA IucC family
OIO85_RS09570	COG4264	IucA IucC family
OIO85_RS09575	COG2814	Major facilitator Superfamily
OIO85_RS09590	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OIO85_RS09605	COG1960	acyl-CoA dehydrogenase activity
OIO85_RS09610	COG1960	acyl-CoA dehydrogenase activity
OIO85_RS09615	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OIO85_RS09620	COG2207	Transcriptional regulator
OIO85_RS09625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OIO85_RS09630	COG0776	regulation of translation
OIO85_RS09655	COG0822	iron-sulfur transferase activity
OIO85_RS09660	COG0316	Belongs to the HesB IscA family
OIO85_RS09690	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OIO85_RS09710	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OIO85_RS09715	COG0702	epimerase
OIO85_RS09750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OIO85_RS09760	COG0339	signal peptide processing
OIO85_RS09770	COG4166	transmembrane transport
OIO85_RS09805	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OIO85_RS09810	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
OIO85_RS09840	COG0776	regulation of translation
OIO85_RS09905	COG0084	hydrolase, TatD family'
OIO85_RS09925	COG1663	tetraacyldisaccharide 4'-kinase activity
OIO85_RS09930	COG1132	(ABC) transporter
OIO85_RS09940	COG0811	peptide transport
OIO85_RS09945	COG1475	DNA binding
OIO85_RS09950	COG1192	Involved in chromosome partitioning
OIO85_RS09960	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
OIO85_RS09975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OIO85_RS09980	COG0191	fructose-bisphosphate aldolase activity
OIO85_RS10000	COG0424	maF-like protein
OIO85_RS10005	COG2850	peptidyl-arginine hydroxylation
OIO85_RS10015	COG0640	Transcriptional regulator
OIO85_RS10025	COG3619	membrane
OIO85_RS10030	COG3122	Protein conserved in bacteria
OIO85_RS10035	COG1132	(ABC) transporter
OIO85_RS10055	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
OIO85_RS10060	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OIO85_RS10070	COG0506	proline dehydrogenase activity
OIO85_RS10070	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
OIO85_RS10070	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
OIO85_RS10075	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
OIO85_RS10090	COG3698	Phosphodiester glycosidase
OIO85_RS10100	COG2353	YceI-like domain
OIO85_RS10110	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
OIO85_RS10155	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
OIO85_RS10155	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OIO85_RS10180	COG3539	Fimbrial protein
OIO85_RS10185	COG3121	Chaperone
OIO85_RS10210	COG0697	spore germination
OIO85_RS10220	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
OIO85_RS10230	COG0583	DNA-binding transcription factor activity
OIO85_RS10250	COG1309	transcriptional regulator
OIO85_RS10265	COG1522	sequence-specific DNA binding
OIO85_RS10275	COG1126	abc transporter atp-binding protein
OIO85_RS10280	COG0765	amino acid transport
OIO85_RS10285	COG0765	amino acid transport
OIO85_RS10315	COG1464	Belongs to the NlpA lipoprotein family
OIO85_RS10325	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OIO85_RS10330	COG2011	ABC-type metal ion transport system permease component
OIO85_RS10335	COG0012	GTP binding
OIO85_RS10360	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
OIO85_RS10400	COG0386	Belongs to the glutathione peroxidase family
OIO85_RS10410	COG0436	Aminotransferase
OIO85_RS10415	COG1301	dicarboxylic acid transport
OIO85_RS10450	COG3634	alkyl hydroperoxide reductase activity
OIO85_RS10465	COG0583	DNA-binding transcription factor activity
OIO85_RS10470	COG0798	PFAM Bile acid sodium symporter
OIO85_RS10475	COG0640	Transcriptional regulator
OIO85_RS10490	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
OIO85_RS10500	COG0583	DNA-binding transcription factor activity
OIO85_RS10510	COG1953	Uracil, thiamine, allantoin
OIO85_RS10520	COG2175	clavaminate synthase activity
OIO85_RS10525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO85_RS10545	COG4521	taurine ABC transporter
OIO85_RS10555	COG0477	Major facilitator Superfamily
OIO85_RS10575	COG1271	oxidase subunit
OIO85_RS10580	COG1294	oxidase, subunit
OIO85_RS10590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO85_RS10610	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
OIO85_RS10630	COG3052	prosthetic group binding
OIO85_RS10635	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
OIO85_RS10645	COG0583	DNA-binding transcription factor activity
OIO85_RS10655	COG2814	Major facilitator Superfamily
OIO85_RS10675	COG1346	cytolysis
OIO85_RS10685	COG0583	DNA-binding transcription factor activity
OIO85_RS10690	COG0625	glutathione transferase activity
OIO85_RS10695	COG0625	glutathione transferase activity
OIO85_RS10700	COG0583	DNA-binding transcription factor activity
OIO85_RS10705	COG1028	Short-chain dehydrogenase reductase Sdr
OIO85_RS10715	COG1045	serine acetyltransferase
OIO85_RS10720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OIO85_RS10725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OIO85_RS10735	COG1280	lysine exporter protein (LysE YggA)
OIO85_RS10750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OIO85_RS10755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OIO85_RS10760	COG1126	abc transporter atp-binding protein
OIO85_RS10765	COG0765	amino acid transport
OIO85_RS10770	COG0765	amino acid transport
OIO85_RS10790	COG2205	protein histidine kinase activity
OIO85_RS10790	COG0784	Response regulator, receiver
OIO85_RS10810	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OIO85_RS10830	COG1028	Short-chain dehydrogenase reductase Sdr
OIO85_RS10880	COG0583	DNA-binding transcription factor activity
OIO85_RS10900	COG0318	PFAM AMP-dependent synthetase and ligase
OIO85_RS10905	COG1309	transcriptional regulator
OIO85_RS10910	COG1960	acyl-CoA dehydrogenase activity
OIO85_RS10915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OIO85_RS10920	COG1024	Enoyl-CoA hydratase
OIO85_RS10925	COG4770	biotin carboxylase activity
OIO85_RS10935	COG0583	DNA-binding transcription factor activity
OIO85_RS10955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OIO85_RS10975	COG3842	ATPase activity
OIO85_RS10980	COG1840	ABC-type Fe3 transport system, periplasmic component
OIO85_RS10995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO85_RS11000	COG1414	Transcriptional regulator
OIO85_RS11010	COG0583	DNA-binding transcription factor activity
OIO85_RS11015	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OIO85_RS11020	COG1012	belongs to the aldehyde dehydrogenase family
OIO85_RS11030	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
OIO85_RS11040	COG1012	belongs to the aldehyde dehydrogenase family
OIO85_RS11045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OIO85_RS11050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO85_RS11055	COG2267	carboxylic ester hydrolase activity
OIO85_RS11075	COG3038	cytochrome b561
OIO85_RS11080	COG0753	catalase activity
OIO85_RS11085	COG2271	Major facilitator Superfamily
OIO85_RS11090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OIO85_RS11095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OIO85_RS11195	COG2207	Transcriptional regulator
OIO85_RS11205	COG1278	Cold shock
OIO85_RS11240	COG0556	nucleotide-excision repair
OIO85_RS11250	COG2050	protein possibly involved in aromatic compounds catabolism
OIO85_RS11260	COG3327	negative regulation of DNA-templated transcription, initiation
OIO85_RS11265	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
OIO85_RS11270	COG0183	Belongs to the thiolase family
OIO85_RS11275	COG1250	3-hydroxyacyl-CoA dehydrogenase
OIO85_RS11280	COG1024	Enoyl-CoA hydratase
OIO85_RS11285	COG1024	Enoyl-CoA hydratase
OIO85_RS11290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO85_RS11295	COG2151	metal-sulfur cluster biosynthetic enzyme
OIO85_RS11300	COG3396	Phenylacetate-CoA oxygenase
OIO85_RS11305	COG3460	Phenylacetate-CoA oxygenase
OIO85_RS11310	COG3396	Phenylacetate-CoA oxygenase
OIO85_RS11315	COG2030	dehydratase
OIO85_RS11315	COG1012	belongs to the aldehyde dehydrogenase family
OIO85_RS11320	COG1760	l-serine dehydratase
OIO85_RS11325	COG0531	amino acid
OIO85_RS11330	COG1012	belongs to the aldehyde dehydrogenase family
OIO85_RS11355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OIO85_RS11375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OIO85_RS11385	COG0789	Transcriptional regulator
OIO85_RS11395	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
OIO85_RS11410	COG2807	transmembrane transport
OIO85_RS11415	COG0590	tRNA wobble adenosine to inosine editing
OIO85_RS11540	COG1116	anion transmembrane transporter activity
OIO85_RS11545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OIO85_RS11555	COG0864	Transcriptional regulator
OIO85_RS11565	COG1733	regulation of RNA biosynthetic process
OIO85_RS11570	COG2249	NAD(P)H dehydrogenase (quinone) activity
OIO85_RS11575	COG0439	Biotin carboxylase
OIO85_RS11590	COG1063	alcohol dehydrogenase
OIO85_RS11600	COG1309	transcriptional regulator
OIO85_RS11640	COG0038	chloride channel
OIO85_RS11645	COG4770	biotin carboxylase activity
OIO85_RS11665	COG1914	H( )-stimulated, divalent metal cation uptake system
OIO85_RS11725	COG1250	3-hydroxyacyl-CoA dehydrogenase
OIO85_RS11750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO85_RS11755	COG1116	anion transmembrane transporter activity
OIO85_RS11760	COG2515	1-aminocyclopropane-1-carboxylate deaminase
OIO85_RS11790	COG0598	Magnesium transport protein CorA
OIO85_RS11800	COG1560	Kdo2-lipid A biosynthetic process
OIO85_RS11810	COG5006	permease, DMT superfamily
OIO85_RS11815	COG1522	sequence-specific DNA binding
OIO85_RS11830	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
OIO85_RS11840	COG4122	O-methyltransferase activity
OIO85_RS11875	COG1137	ATPase activity
OIO85_RS11880	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
OIO85_RS11890	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
OIO85_RS11895	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
OIO85_RS11895	COG0517	IMP dehydrogenase activity
OIO85_RS11935	COG2814	Major facilitator Superfamily
OIO85_RS11970	COG1278	Cold shock
OIO85_RS11975	COG1280	lysine exporter protein (LysE YggA)
OIO85_RS12005	COG1570	exodeoxyribonuclease VII activity
OIO85_RS12055	COG0583	DNA-binding transcription factor activity
OIO85_RS12065	COG4638	Rieske (2fe-2S)
OIO85_RS12075	COG0543	2 iron, 2 sulfur cluster binding
OIO85_RS12075	COG0633	Ferredoxin
OIO85_RS12080	COG1028	Short-chain dehydrogenase reductase Sdr
OIO85_RS12085	COG3135	benzoate transporter
OIO85_RS12090	COG2814	Major facilitator Superfamily
OIO85_RS12105	COG1643	Atp-dependent helicase
OIO85_RS12110	COG0450	alkyl hydroperoxide reductase
OIO85_RS12120	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
OIO85_RS12130	COG3634	alkyl hydroperoxide reductase activity
OIO85_RS12150	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OIO85_RS12310	COG0625	glutathione transferase activity
OIO85_RS12320	COG2885	chlorophyll binding
OIO85_RS12355	COG0542	response to heat
OIO85_RS12370	COG1765	OsmC-like protein
OIO85_RS12385	COG0667	Aldo Keto reductase
OIO85_RS12400	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OIO85_RS12415	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OIO85_RS12425	COG0527	aspartate kinase activity
OIO85_RS12435	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
OIO85_RS12445	COG3038	cytochrome b561
OIO85_RS12450	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
OIO85_RS12455	COG2252	PERMEase
OIO85_RS12465	COG2072	flavoprotein involved in K transport
OIO85_RS12480	COG1741	Belongs to the pirin family
OIO85_RS12485	COG1309	transcriptional regulator
OIO85_RS12495	COG0300	oxidoreductase activity
OIO85_RS12500	COG2072	flavoprotein involved in K transport
OIO85_RS12505	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
OIO85_RS12550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO85_RS12570	COG2814	Major facilitator Superfamily
OIO85_RS12575	COG1024	Enoyl-CoA hydratase
OIO85_RS12580	COG1012	belongs to the aldehyde dehydrogenase family
OIO85_RS12590	COG1960	acyl-CoA dehydrogenase activity
OIO85_RS12615	COG2186	Transcriptional regulator
OIO85_RS12620	COG1012	belongs to the aldehyde dehydrogenase family
OIO85_RS12630	COG4948	Mandelate Racemase Muconate Lactonizing
OIO85_RS12635	COG2271	Major facilitator Superfamily
OIO85_RS12640	COG2721	sulfolactate sulfo-lyase activity
OIO85_RS12645	COG0697	spore germination
OIO85_RS12690	COG1113	amino acid transport
OIO85_RS12710	COG1012	belongs to the aldehyde dehydrogenase family
OIO85_RS12730	COG0531	amino acid
OIO85_RS12740	COG1113	amino acid transport
OIO85_RS12780	COG3209	COG3209 Rhs family protein
OIO85_RS12800	COG4269	membrane
OIO85_RS12815	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO85_RS12815	COG1902	pentaerythritol trinitrate reductase activity
OIO85_RS12825	COG4251	negative regulation of phosphorylation
OIO85_RS12825	COG5001	Diguanylate cyclase
OIO85_RS12825	COG2203	Gaf domain
OIO85_RS12825	COG3706	GGDEF domain
OIO85_RS12835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OIO85_RS12860	COG4172	Belongs to the ABC transporter superfamily
OIO85_RS12865	COG4239	(ABC) transporter, permease
OIO85_RS12870	COG4174	ABC transporter (Permease)
OIO85_RS12880	COG0741	lytic transglycosylase activity
OIO85_RS12880	COG1388	LysM domain
OIO85_RS12880	COG0741	lytic transglycosylase activity
OIO85_RS12880	COG1388	LysM domain
OIO85_RS12885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OIO85_RS12925	COG0583	DNA-binding transcription factor activity
OIO85_RS12930	COG1279	arginine transmembrane transporter activity
OIO85_RS12950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO85_RS12955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO85_RS12960	COG0006	proline dipeptidase activity
OIO85_RS12995	COG2194	sulfuric ester hydrolase activity
OIO85_RS13160	COG5410	chromosome segregation
OIO85_RS13340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OIO85_RS13360	COG3384	dioxygenase
OIO85_RS13370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
OIO85_RS13375	COG2878	Part of a membrane complex involved in electron transport
OIO85_RS13380	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OIO85_RS13405	COG0768	penicillin binding
OIO85_RS13410	COG0742	ribosomal rna small subunit methyltransferase
OIO85_RS13425	COG0830	nickel cation binding
OIO85_RS13435	COG0804	urea catabolic process
OIO85_RS13475	COG1253	flavin adenine dinucleotide binding
OIO85_RS13480	COG2851	Citrate transporter
OIO85_RS13530	COG1773	rubredoxin
OIO85_RS13535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO85_RS13545	COG0583	DNA-binding transcription factor activity
OIO85_RS13575	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
OIO85_RS13580	COG4181	ATPase activity
OIO85_RS13625	COG1262	PFAM Formylglycine-generating sulfatase enzyme
OIO85_RS13650	COG0306	phosphate transporter
OIO85_RS13660	COG3958	Transketolase
OIO85_RS13665	COG3959	Transketolase, thiamine diphosphate binding domain
OIO85_RS13670	COG2271	Major facilitator Superfamily
OIO85_RS13675	COG1028	Short-chain dehydrogenase reductase Sdr
OIO85_RS13680	COG0583	DNA-binding transcription factor activity
OIO85_RS13700	COG2207	Transcriptional regulator
OIO85_RS13705	COG2066	Belongs to the glutaminase family
OIO85_RS13710	COG0242	peptide deformylase activity
OIO85_RS13715	COG0477	Major facilitator Superfamily
OIO85_RS13725	COG0028	Belongs to the TPP enzyme family
OIO85_RS13740	COG1028	Short-chain dehydrogenase reductase Sdr
OIO85_RS13745	COG2267	carboxylic ester hydrolase activity
OIO85_RS13755	COG2271	Major facilitator Superfamily
OIO85_RS13760	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO85_RS13770	COG1028	Short-chain dehydrogenase reductase Sdr
OIO85_RS13790	COG1414	Transcriptional regulator
OIO85_RS13805	COG1024	Enoyl-CoA hydratase
OIO85_RS13815	COG1215	transferase activity, transferring glycosyl groups
OIO85_RS13820	COG0726	polysaccharide deacetylase
OIO85_RS13820	COG1649	PFAM Uncharacterised BCR, COG1649
OIO85_RS13830	COG4681	YaeQ
OIO85_RS13840	COG0523	cobalamin synthesis protein
OIO85_RS13850	COG1607	acyl-coa hydrolase
OIO85_RS13860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OIO85_RS13865	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OIO85_RS13870	COG1309	transcriptional regulator
OIO85_RS13895	COG2040	homocysteine
OIO85_RS13900	COG0531	amino acid
OIO85_RS13955	COG1595	DNA-templated transcription, initiation
OIO85_RS13965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OIO85_RS13970	COG0477	Major facilitator Superfamily
OIO85_RS13980	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
OIO85_RS14040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OIO85_RS14125	COG0592	DNA-directed DNA polymerase activity
OIO85_RS14165	COG2026	Addiction module toxin, RelE StbE family
OIO85_RS14385	COG1484	DNA-dependent DNA replication
OIO85_RS14470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OIO85_RS14550	COG0405	Gamma-glutamyltransferase
OIO85_RS14555	COG2814	Major facilitator Superfamily
OIO85_RS14565	COG2050	protein possibly involved in aromatic compounds catabolism
OIO85_RS14580	COG1090	epimerase
OIO85_RS14600	COG0420	3'-5' exonuclease activity
OIO85_RS14625	COG0735	belongs to the Fur family
OIO85_RS14630	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OIO85_RS14650	COG0121	glutamine amidotransferase
OIO85_RS14665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OIO85_RS14675	COG0210	DNA helicase
OIO85_RS14680	COG2885	chlorophyll binding
OIO85_RS14685	COG0204	Acyl-transferase
OIO85_RS14700	COG2894	cell division
OIO85_RS14715	COG1280	lysine exporter protein (LysE YggA)
OIO85_RS14720	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OIO85_RS14720	COG1674	ftsk spoiiie
OIO85_RS14725	COG0492	ferredoxin-NADP+ reductase activity
OIO85_RS14730	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
OIO85_RS14740	COG0456	acetyltransferase
OIO85_RS14785	COG1981	membrane
OIO85_RS14800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OIO85_RS14800	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
OIO85_RS14820	COG1012	belongs to the aldehyde dehydrogenase family
OIO85_RS14830	COG0657	acetylesterase activity
OIO85_RS14840	COG0473	3-isopropylmalate dehydrogenase activity
OIO85_RS14845	COG0583	DNA-binding transcription factor activity
OIO85_RS14875	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OIO85_RS14900	COG0564	pseudouridine synthase activity
OIO85_RS14910	COG0358	DNA primase activity
OIO85_RS14925	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
OIO85_RS14955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OIO85_RS14985	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OIO85_RS14995	COG0351	phosphomethylpyrimidine kinase
OIO85_RS14995	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OIO85_RS14995	COG0352	thiamine-phosphate diphosphorylase activity
OIO85_RS15000	COG1652	LysM domain
OIO85_RS15025	COG1399	metal-binding, possibly nucleic acid-binding protein
OIO85_RS15030	COG3101	peptidyl-lysine hydroxylation
OIO85_RS15035	COG0009	L-threonylcarbamoyladenylate synthase
OIO85_RS15040	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
OIO85_RS15045	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
OIO85_RS15060	COG4106	trans-aconitate 2-methyltransferase activity
OIO85_RS15075	COG0596	Alpha beta hydrolase
OIO85_RS15075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OIO85_RS15075	COG2226	methyltransferase
OIO85_RS15080	COG1877	trehalose-phosphatase activity
OIO85_RS15085	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
OIO85_RS15090	COG2223	nitrite transmembrane transporter activity
OIO85_RS15110	COG1196	nuclear chromosome segregation
OIO85_RS15120	COG0730	response to heat
OIO85_RS15135	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OIO85_RS15145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OIO85_RS15195	COG0489	protein tyrosine kinase activity
OIO85_RS15205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OIO85_RS15205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OIO85_RS15235	COG2515	1-aminocyclopropane-1-carboxylate deaminase
OIO85_RS15240	COG2081	HI0933 family
OIO85_RS15250	COG0668	transmembrane transport
OIO85_RS15270	COG0583	DNA-binding transcription factor activity
OIO85_RS15295	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OIO85_RS15300	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OIO85_RS15330	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
OIO85_RS15370	COG0745	RESPONSE REGULATOR receiver
OIO85_RS15390	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OIO85_RS15395	COG0697	spore germination
OIO85_RS15430	COG0477	Major facilitator Superfamily
OIO85_RS15440	COG1028	Short-chain dehydrogenase reductase Sdr
OIO85_RS15460	COG0384	phenazine biosynthesis protein PhzF
OIO85_RS15505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO85_RS15520	COG0583	DNA-binding transcription factor activity
OIO85_RS15530	COG0583	DNA-binding transcription factor activity
OIO85_RS15545	COG0583	DNA-binding transcription factor activity
OIO85_RS15550	COG1053	succinate dehydrogenase
OIO85_RS15560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OIO85_RS15565	COG2814	Major facilitator Superfamily
OIO85_RS15570	COG1960	acyl-CoA dehydrogenase activity
OIO85_RS15575	COG0583	DNA-binding transcription factor activity
OIO85_RS15580	COG1063	alcohol dehydrogenase
OIO85_RS15610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
OIO85_RS15615	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
OIO85_RS15620	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OIO85_RS15640	COG2132	Multicopper oxidase
OIO85_RS15650	COG0561	phosphatase activity
OIO85_RS15655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OIO85_RS15665	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
OIO85_RS15680	COG1214	PFAM Peptidase M22, glycoprotease
OIO85_RS15750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OIO85_RS15755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OIO85_RS15760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OIO85_RS15820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OIO85_RS15830	COG1846	Transcriptional regulator
OIO85_RS15835	COG1764	response to oxidative stress
OIO85_RS15875	COG0037	tRNA processing
OIO85_RS15885	COG0248	Ppx GppA phosphatase
OIO85_RS15915	COG0072	phenylalanine-tRNA ligase activity
OIO85_RS15960	COG1238	metal cluster binding
OIO85_RS15965	COG0625	glutathione transferase activity
OIO85_RS15980	COG0318	PFAM AMP-dependent synthetase and ligase
OIO85_RS15985	COG3028	Belongs to the UPF0307 family
OIO85_RS15990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OIO85_RS16010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OIO85_RS16015	COG0617	tRNA 3'-terminal CCA addition
OIO85_RS16020	COG1555	photosystem II stabilization
OIO85_RS16025	COG3956	TIGRFAM MazG family protein
OIO85_RS16035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OIO85_RS16055	COG0784	Response regulator, receiver
OIO85_RS16055	COG5002	protein histidine kinase activity
OIO85_RS16055	COG2205	protein histidine kinase activity
OIO85_RS16060	COG1024	Enoyl-CoA hydratase
OIO85_RS16065	COG2084	Dehydrogenase
OIO85_RS16070	COG3622	Belongs to the hyi family
OIO85_RS16105	COG0697	spore germination
OIO85_RS16115	COG2814	Major facilitator Superfamily
OIO85_RS16125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OIO85_RS16195	COG4774	siderophore transport
OIO85_RS16210	COG1271	oxidase subunit
OIO85_RS16215	COG1294	oxidase, subunit
OIO85_RS16285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OIO85_RS16295	COG0583	DNA-binding transcription factor activity
OIO85_RS16305	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
OIO85_RS16315	COG0084	hydrolase, TatD family'
OIO85_RS16330	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OIO85_RS16360	COG0440	acetolactate synthase activity
OIO85_RS16365	COG0028	Belongs to the TPP enzyme family
OIO85_RS16390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO85_RS16395	COG1136	(ABC) transporter
OIO85_RS16395	COG0577	efflux transmembrane transporter activity
OIO85_RS16400	COG1538	Outer membrane efflux protein
OIO85_RS16415	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
OIO85_RS16420	COG1162	GTPase activity
OIO85_RS16430	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OIO85_RS16470	COG1426	Protein conserved in bacteria
OIO85_RS16505	COG0793	Belongs to the peptidase S41A family
OIO85_RS16520	COG2267	carboxylic ester hydrolase activity
OIO85_RS16530	COG1012	belongs to the aldehyde dehydrogenase family
OIO85_RS16535	COG3265	gluconokinase activity
OIO85_RS16545	COG0800	Aldolase
OIO85_RS16555	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OIO85_RS16560	COG0280	phosphate acetyltransferase
OIO85_RS16560	COG0857	belongs to the CobB CobQ family
OIO85_RS16565	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
OIO85_RS16565	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
OIO85_RS16585	COG0740	serine-type endopeptidase activity
OIO85_RS16595	COG4774	siderophore transport
OIO85_RS16605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OIO85_RS16615	COG2813	Specifically methylates the guanine in position
OIO85_RS16615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OIO85_RS16715	COG0788	formyltetrahydrofolate deformylase activity
OIO85_RS16740	COG4651	solute:proton antiporter activity
OIO85_RS16740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OIO85_RS16760	COG0724	RNA recognition motif
OIO85_RS16765	COG0210	DNA helicase
OIO85_RS16790	COG1733	regulation of RNA biosynthetic process
OIO85_RS16800	COG2900	Belongs to the SlyX family
OIO85_RS16805	COG0488	(ABC) transporter
OIO85_RS16810	COG1280	lysine exporter protein (LysE YggA)
OIO85_RS16815	COG1560	Kdo2-lipid A biosynthetic process
OIO85_RS16825	COG1301	dicarboxylic acid transport
OIO85_RS16880	COG0473	3-isopropylmalate dehydrogenase activity
OIO85_RS16935	COG0583	DNA-binding transcription factor activity
OIO85_RS16945	COG0625	glutathione transferase activity
OIO85_RS16950	COG2378	regulation of single-species biofilm formation
OIO85_RS16955	COG0546	phosphoglycolate phosphatase activity
OIO85_RS16965	COG1530	ribonuclease E activity
OIO85_RS16970	COG0318	PFAM AMP-dependent synthetase and ligase
OIO85_RS16985	COG0583	DNA-binding transcription factor activity
OIO85_RS16990	COG1028	Short-chain dehydrogenase reductase Sdr
OIO85_RS16995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OIO85_RS17005	COG0534	Mate efflux family protein
OIO85_RS17020	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OIO85_RS17045	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
OIO85_RS17045	COG0493	'glutamate synthase
OIO85_RS17055	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
OIO85_RS17060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OIO85_RS17075	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
OIO85_RS17085	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
OIO85_RS17085	COG0644	oxidoreductase
OIO85_RS17095	COG0425	Belongs to the sulfur carrier protein TusA family
OIO85_RS17100	COG4535	Mg2 and Co2 transporter CorC
OIO85_RS17110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OIO85_RS17130	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OIO85_RS17135	COG0475	glutathione-regulated potassium exporter activity
OIO85_RS17135	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OIO85_RS17150	COG0484	heat shock protein binding
OIO85_RS17155	COG0789	Transcriptional regulator
OIO85_RS17160	COG0598	Magnesium transport protein CorA
OIO85_RS17175	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OIO85_RS17180	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OIO85_RS17185	COG1074	ATP-dependent DNA helicase activity
OIO85_RS17190	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
OIO85_RS17210	COG2226	methyltransferase
OIO85_RS17230	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OIO85_RS17245	COG2111	Na H antiporter
OIO85_RS17245	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OIO85_RS17250	COG1006	Multisubunit Na H antiporter MnhC subunit
OIO85_RS17255	COG0651	ATP synthesis coupled electron transport
OIO85_RS17260	COG1863	multisubunit Na H antiporter MnhE subunit
OIO85_RS17265	COG2212	antiporter activity
OIO85_RS17270	COG1320	monovalent cation:proton antiporter activity
OIO85_RS17285	COG0195	Participates in both transcription termination and antitermination
OIO85_RS17335	COG0237	dephospho-CoA kinase activity
OIO85_RS17345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OIO85_RS17360	COG0497	DNA recombination
OIO85_RS17370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
OIO85_RS17400	COG2169	Transcriptional regulator
OIO85_RS17400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OIO85_RS17405	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OIO85_RS17465	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OIO85_RS17480	COG0326	Molecular chaperone. Has ATPase activity
OIO85_RS17495	COG2056	Na+-H+ antiporter family
OIO85_RS17595	COG0546	phosphoglycolate phosphatase activity
OIO85_RS17600	COG1716	ATPase activity
OIO85_RS17645	COG0181	hydroxymethylbilane synthase activity
OIO85_RS17655	COG3275	phosphorelay sensor kinase activity
OIO85_RS17675	COG1538	Outer membrane efflux protein
OIO85_RS17680	COG0697	spore germination
OIO85_RS17725	COG1061	Type III restriction enzyme res subunit
OIO85_RS17730	COG1002	Type II restriction enzyme, methylase subunits
OIO85_RS17740	COG0659	secondary active sulfate transmembrane transporter activity
OIO85_RS17745	COG0589	response to stress
OIO85_RS17790	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
OIO85_RS17795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
OIO85_RS17800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OIO85_RS17805	COG0772	Belongs to the SEDS family
OIO85_RS17830	COG4974	Belongs to the 'phage' integrase family
OIO85_RS17835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OIO85_RS17845	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
OIO85_RS17855	COG2197	response regulator
OIO85_RS17870	COG0793	Belongs to the peptidase S41A family
OIO85_RS17875	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
OIO85_RS17880	COG0795	lipopolysaccharide-transporting ATPase activity
OIO85_RS17920	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OIO85_RS17920	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OIO85_RS17930	COG0004	ammonium transporteR
OIO85_RS17935	COG0347	Belongs to the P(II) protein family
OIO85_RS17970	COG1061	Type III restriction enzyme res subunit
OIO85_RS17975	COG1002	Type II restriction enzyme, methylase subunits
OIO85_RS17990	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
OIO85_RS18005	COG0318	PFAM AMP-dependent synthetase and ligase
OIO85_RS18015	COG0477	Major facilitator Superfamily
OIO85_RS18020	COG2860	membrane
OIO85_RS18030	COG1253	flavin adenine dinucleotide binding
OIO85_RS18040	COG0477	Major facilitator Superfamily
OIO85_RS18045	COG3757	hydrolase, family 25
OIO85_RS18050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OIO85_RS18090	COG0655	NAD(P)H dehydrogenase (quinone) activity
OIO85_RS18100	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OIO85_RS18170	COG0758	DNA mediated transformation
OIO85_RS18180	COG0697	spore germination
OIO85_RS18185	COG1309	transcriptional regulator
OIO85_RS18200	COG0386	Belongs to the glutathione peroxidase family
OIO85_RS18265	COG1121	(ABC) transporter
OIO85_RS18270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OIO85_RS18275	COG1280	lysine exporter protein (LysE YggA)
OIO85_RS18280	COG2837	iron assimilation
OIO85_RS18290	COG0281	malic enzyme
OIO85_RS18335	COG0519	Catalyzes the synthesis of GMP from XMP
OIO85_RS18335	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OIO85_RS18340	COG4399	Belongs to the UPF0754 family
OIO85_RS18345	COG2259	Doxx family
OIO85_RS18350	COG0586	Pfam SNARE associated Golgi protein
OIO85_RS18365	COG1192	Involved in chromosome partitioning
OIO85_RS18375	COG0271	Belongs to the BolA IbaG family
OIO85_RS18395	COG2267	carboxylic ester hydrolase activity
OIO85_RS18415	COG3321	synthase
OIO85_RS18415	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
OIO85_RS18415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OIO85_RS18415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OIO85_RS18420	COG1960	acyl-CoA dehydrogenase activity
OIO85_RS18430	COG2197	response regulator
OIO85_RS18440	COG3916	Acyl-homoserine-lactone synthase
OIO85_RS18445	COG0477	Major facilitator Superfamily
OIO85_RS18450	COG1024	Enoyl-CoA hydratase
OIO85_RS18455	COG1024	Enoyl-CoA hydratase
OIO85_RS18460	COG1960	acyl-CoA dehydrogenase activity
OIO85_RS18465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OIO85_RS18485	COG1113	amino acid transport
OIO85_RS18490	COG1113	amino acid transport
OIO85_RS18495	COG0251	oxidation-reduction process
OIO85_RS18535	COG0564	pseudouridine synthase activity
OIO85_RS18565	COG1051	belongs to the nudix hydrolase family
OIO85_RS18590	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
OIO85_RS18605	COG1802	Transcriptional regulator
OIO85_RS18615	COG1448	Aminotransferase
OIO85_RS18620	COG0277	FAD linked oxidase domain protein
OIO85_RS18630	COG2186	Transcriptional regulator
OIO85_RS18640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OIO85_RS18645	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OIO85_RS18660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OIO85_RS18670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
OIO85_RS18680	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
OIO85_RS18685	COG0438	transferase activity, transferring glycosyl groups
OIO85_RS18695	COG0438	transferase activity, transferring glycosyl groups
OIO85_RS18715	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
OIO85_RS18745	COG0728	peptidoglycan biosynthetic process
OIO85_RS18750	COG3023	N-Acetylmuramoyl-L-alanine amidase
OIO85_RS18785	COG1017	nitric oxide dioxygenase activity
OIO85_RS18785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO85_RS18810	COG0546	phosphoglycolate phosphatase activity
OIO85_RS18815	COG1028	Short-chain dehydrogenase reductase Sdr
OIO85_RS18835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO85_RS18840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO85_RS18845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OIO85_RS18850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO85_RS18855	COG1116	anion transmembrane transporter activity
OIO85_RS18860	COG1309	transcriptional regulator
OIO85_RS18865	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
OIO85_RS18875	COG0196	riboflavin kinase activity
OIO85_RS18880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OIO85_RS18890	COG1047	Peptidyl-prolyl cis-trans
OIO85_RS18930	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OIO85_RS18935	COG0657	acetylesterase activity
OIO85_RS18955	COG0583	DNA-binding transcription factor activity
OIO85_RS18985	COG2951	lytic endotransglycosylase activity
OIO85_RS18990	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
OIO85_RS19005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OIO85_RS19015	COG0671	phosphoesterase, PA-phosphatase related
OIO85_RS19020	COG0861	Integral membrane protein TerC family
OIO85_RS19030	COG0754	glutathionylspermidine amidase activity
OIO85_RS19040	COG0402	S-adenosylhomocysteine deaminase activity
OIO85_RS19055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OIO85_RS19060	COG1230	cation diffusion facilitator family transporter
OIO85_RS19075	COG0706	membrane insertase activity
OIO85_RS19125	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
OIO85_RS19130	COG0627	Serine hydrolase involved in the detoxification of formaldehyde