locus-tag	class	description
OIO60_RS00010	COG0592	DNA-directed DNA polymerase activity
OIO60_RS00020	COG0187	DNA topoisomerase II activity
OIO60_RS00030	COG0586	Pfam SNARE associated Golgi protein
OIO60_RS00035	COG0488	(ABC) transporter
OIO60_RS00060	COG0596	Alpha beta hydrolase
OIO60_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
OIO60_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OIO60_RS00110	COG0733	neurotransmitter:sodium symporter activity
OIO60_RS00150	COG2233	PERMEase
OIO60_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO60_RS00200	COG2814	Major facilitator Superfamily
OIO60_RS00205	COG0656	L-ascorbic acid biosynthetic process
OIO60_RS00210	COG0583	DNA-binding transcription factor activity
OIO60_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO60_RS00230	COG1064	alcohol dehydrogenase
OIO60_RS00235	COG2818	Glycosylase
OIO60_RS00250	COG1194	a g-specific adenine glycosylase
OIO60_RS00270	COG2983	Belongs to the UPF0260 family
OIO60_RS00275	COG2133	pyrroloquinoline quinone binding
OIO60_RS00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OIO60_RS00285	COG2116	formate transmembrane transporter activity
OIO60_RS00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OIO60_RS00310	COG1335	isochorismatase
OIO60_RS00320	COG0534	Mate efflux family protein
OIO60_RS00325	COG1683	Conserved Protein
OIO60_RS00345	COG0625	glutathione transferase activity
OIO60_RS00355	COG1113	amino acid transport
OIO60_RS00365	COG0523	cobalamin synthesis protein
OIO60_RS00375	COG2188	Transcriptional regulator
OIO60_RS00405	COG0010	Belongs to the arginase family
OIO60_RS00425	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
OIO60_RS00430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OIO60_RS00440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
OIO60_RS00445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
OIO60_RS00545	COG0534	Mate efflux family protein
OIO60_RS00550	COG0436	Aminotransferase
OIO60_RS00555	COG2733	membrane
OIO60_RS00570	COG2918	glutathione biosynthetic process
OIO60_RS00600	COG3150	esterase
OIO60_RS00610	COG1028	Short-chain dehydrogenase reductase Sdr
OIO60_RS00615	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
OIO60_RS00625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO60_RS00635	COG2233	PERMEase
OIO60_RS00640	COG2351	hydroxyisourate hydrolase activity
OIO60_RS00675	COG3706	GGDEF domain
OIO60_RS00690	COG1393	Belongs to the ArsC family
OIO60_RS00695	COG0708	Exodeoxyribonuclease III
OIO60_RS00730	COG0589	response to stress
OIO60_RS00735	COG0659	secondary active sulfate transmembrane transporter activity
OIO60_RS00765	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OIO60_RS00810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OIO60_RS00855	COG0189	ligase activity
OIO60_RS00875	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
OIO60_RS00885	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OIO60_RS00900	COG4942	peptidase
OIO60_RS00910	COG0508	dehydrogenase complex catalyzes the overall conversion of
OIO60_RS00920	COG2119	membrane
OIO60_RS00925	COG4774	siderophore transport
OIO60_RS00930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO60_RS00930	COG0426	domain, Protein
OIO60_RS00955	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OIO60_RS00975	COG1902	pentaerythritol trinitrate reductase activity
OIO60_RS00980	COG1519	Transferase
OIO60_RS00985	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OIO60_RS00990	COG0668	transmembrane transport
OIO60_RS01000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OIO60_RS01005	COG1335	isochorismatase
OIO60_RS01010	COG1522	sequence-specific DNA binding
OIO60_RS01015	COG3328	transposase activity
OIO60_RS01040	COG2198	Histidine kinase
OIO60_RS01040	COG0784	Response regulator, receiver
OIO60_RS01040	COG2205	protein histidine kinase activity
OIO60_RS01045	COG3162	membrane
OIO60_RS01050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OIO60_RS01060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OIO60_RS01080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OIO60_RS01085	COG1309	transcriptional regulator
OIO60_RS01105	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OIO60_RS01105	COG0352	thiamine-phosphate diphosphorylase activity
OIO60_RS01105	COG0351	phosphomethylpyrimidine kinase
OIO60_RS01115	COG2814	Major facilitator Superfamily
OIO60_RS01130	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
OIO60_RS01140	COG1113	amino acid transport
OIO60_RS01150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OIO60_RS01155	COG1012	belongs to the aldehyde dehydrogenase family
OIO60_RS01165	COG1335	isochorismatase
OIO60_RS01195	COG2814	Major facilitator Superfamily
OIO60_RS01200	COG0583	DNA-binding transcription factor activity
OIO60_RS01220	COG0667	Aldo Keto reductase
OIO60_RS01255	COG1733	regulation of RNA biosynthetic process
OIO60_RS01260	COG2249	NAD(P)H dehydrogenase (quinone) activity
OIO60_RS01325	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
OIO60_RS01340	COG2329	Antibiotic biosynthesis monooxygenase
OIO60_RS01380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
OIO60_RS01410	COG0427	acetyl-CoA hydrolase
OIO60_RS01435	COG0659	secondary active sulfate transmembrane transporter activity
OIO60_RS01440	COG4221	oxidoreductase activity
OIO60_RS01445	COG2873	o-acetylhomoserine
OIO60_RS01450	COG0488	(ABC) transporter
OIO60_RS01535	COG0833	amino acid
OIO60_RS01580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OIO60_RS01585	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OIO60_RS01600	COG2226	methyltransferase
OIO60_RS01650	COG0069	glutamate synthase activity
OIO60_RS01650	COG0067	glutamate synthase
OIO60_RS01650	COG0070	glutamate synthase
OIO60_RS01655	COG0493	'glutamate synthase
OIO60_RS01665	COG1704	LemA family
OIO60_RS01670	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
OIO60_RS01680	COG4969	Belongs to the N-Me-Phe pilin family
OIO60_RS01685	COG3307	-O-antigen
OIO60_RS01705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OIO60_RS01720	COG0194	GDP metabolic process
OIO60_RS01770	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OIO60_RS01790	COG5380	lipid catabolic process
OIO60_RS01795	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
OIO60_RS01820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OIO60_RS01825	COG0277	FAD linked oxidase domain protein
OIO60_RS01835	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
OIO60_RS01840	COG2249	NAD(P)H dehydrogenase (quinone) activity
OIO60_RS01855	COG1289	transmembrane transporter activity
OIO60_RS01865	COG0628	permease
OIO60_RS01870	COG1192	Involved in chromosome partitioning
OIO60_RS01900	COG0833	amino acid
OIO60_RS01905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
OIO60_RS01910	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OIO60_RS01920	COG1012	belongs to the aldehyde dehydrogenase family
OIO60_RS01960	COG0583	DNA-binding transcription factor activity
OIO60_RS02005	COG0517	IMP dehydrogenase activity
OIO60_RS02010	COG1983	PspC domain protein
OIO60_RS02020	COG1960	acyl-CoA dehydrogenase activity
OIO60_RS02035	COG0408	coproporphyrinogen oxidase activity
OIO60_RS02055	COG0513	Belongs to the DEAD box helicase family
OIO60_RS02065	COG1127	ABC transporter
OIO60_RS02070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OIO60_RS02080	COG2854	intermembrane phospholipid transfer
OIO60_RS02090	COG0598	Magnesium transport protein CorA
OIO60_RS02100	COG0494	nUDIX hydrolase
OIO60_RS02105	COG1040	competence protein
OIO60_RS02110	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OIO60_RS02130	COG1946	Acyl-CoA thioesterase
OIO60_RS02135	COG1301	dicarboxylic acid transport
OIO60_RS02150	COG1959	2 iron, 2 sulfur cluster binding
OIO60_RS02155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO60_RS02155	COG1017	nitric oxide dioxygenase activity
OIO60_RS02160	COG0433	COG0433 Predicted ATPase
OIO60_RS02165	COG0626	cystathionine gamma-synthase activity
OIO60_RS02320	COG1960	acyl-CoA dehydrogenase activity
OIO60_RS02325	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
OIO60_RS02355	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
OIO60_RS02360	COG0339	signal peptide processing
OIO60_RS02365	COG0557	exoribonuclease II activity
OIO60_RS02410	COG0179	Fumarylacetoacetate (FAA) hydrolase
OIO60_RS02415	COG2169	Transcriptional regulator
OIO60_RS02420	COG0697	spore germination
OIO60_RS02425	COG1295	ribonuclease BN
OIO60_RS02460	COG1702	phosphate starvation-inducible protein PhoH
OIO60_RS02470	COG0741	lytic transglycosylase activity
OIO60_RS02470	COG0739	heme binding
OIO60_RS02470	COG1196	nuclear chromosome segregation
OIO60_RS02500	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
OIO60_RS02505	COG1183	phosphatidylcholine synthase activity
OIO60_RS02550	COG1960	acyl-CoA dehydrogenase activity
OIO60_RS02555	COG1309	transcriptional regulator
OIO60_RS02570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OIO60_RS02575	COG1960	acyl-CoA dehydrogenase activity
OIO60_RS02595	COG2969	positive regulation of protein catabolic process
OIO60_RS02605	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OIO60_RS02620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OIO60_RS02625	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OIO60_RS02645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OIO60_RS02655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OIO60_RS02660	COG1408	metallophosphoesterase
OIO60_RS02670	COG2199	diguanylate cyclase activity
OIO60_RS02730	COG1607	acyl-coa hydrolase
OIO60_RS02760	COG2350	Protein conserved in bacteria
OIO60_RS02770	COG0613	PHP domain protein
OIO60_RS02775	COG3781	membrane
OIO60_RS02785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OIO60_RS02790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OIO60_RS02800	COG1862	Preprotein translocase
OIO60_RS02850	COG2205	protein histidine kinase activity
OIO60_RS02855	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
OIO60_RS02875	COG0726	polysaccharide deacetylase
OIO60_RS02880	COG0463	Glycosyl transferase, family 2
OIO60_RS02885	COG0438	transferase activity, transferring glycosyl groups
OIO60_RS02950	COG0625	glutathione transferase activity
OIO60_RS02955	COG0583	DNA-binding transcription factor activity
OIO60_RS02960	COG1960	acyl-CoA dehydrogenase activity
OIO60_RS02965	COG1960	acyl-CoA dehydrogenase activity
OIO60_RS02975	COG2205	protein histidine kinase activity
OIO60_RS02980	COG0745	RESPONSE REGULATOR receiver
OIO60_RS02985	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
OIO60_RS03005	COG2096	Adenosyltransferase
OIO60_RS03055	COG0285	dihydrofolate synthase activity
OIO60_RS03075	COG0450	alkyl hydroperoxide reductase
OIO60_RS03090	COG0477	Major facilitator Superfamily
OIO60_RS03095	COG1272	protein, Hemolysin III
OIO60_RS03125	COG0183	Belongs to the thiolase family
OIO60_RS03130	COG2207	Transcriptional regulator
OIO60_RS03150	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO60_RS03170	COG0183	Belongs to the thiolase family
OIO60_RS03180	COG2885	chlorophyll binding
OIO60_RS03180	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
OIO60_RS03190	COG1690	Belongs to the RtcB family
OIO60_RS03195	COG0833	amino acid
OIO60_RS03205	COG2233	PERMEase
OIO60_RS03210	COG1217	gtp-binding protein TYPA
OIO60_RS03235	COG2094	Belongs to the DNA glycosylase MPG family
OIO60_RS03240	COG4772	TonB-dependent receptor
OIO60_RS03245	COG1902	pentaerythritol trinitrate reductase activity
OIO60_RS03260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OIO60_RS03265	COG0354	folic acid binding
OIO60_RS03275	COG3189	MarR family transcriptional regulator
OIO60_RS03280	COG2824	Alkylphosphonate utilization operon protein PhnA
OIO60_RS03285	COG3422	double-strand break repair
OIO60_RS03325	COG0840	transmembrane signaling receptor activity
OIO60_RS03345	COG5510	response to toxic substance
OIO60_RS03355	COG2832	Protein of unknown function (DUF454)
OIO60_RS03360	COG1376	ErfK ybiS ycfS ynhG family protein
OIO60_RS03400	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OIO60_RS03410	COG1289	transmembrane transporter activity
OIO60_RS03415	COG2814	Major facilitator Superfamily
OIO60_RS03435	COG1115	amino acid carrier protein
OIO60_RS03440	COG1752	Esterase of the alpha-beta hydrolase superfamily
OIO60_RS03445	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OIO60_RS03450	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
OIO60_RS03480	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OIO60_RS03490	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OIO60_RS03495	COG1077	Cell shape determining protein MreB Mrl
OIO60_RS03500	COG1792	Involved in formation and maintenance of cell shape
OIO60_RS03505	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
OIO60_RS03510	COG0424	maF-like protein
OIO60_RS03515	COG1530	ribonuclease E activity
OIO60_RS03525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO60_RS03535	COG0560	Phosphoserine phosphatase
OIO60_RS03545	COG2249	NAD(P)H dehydrogenase (quinone) activity
OIO60_RS03570	COG2207	Transcriptional regulator
OIO60_RS03590	COG1113	amino acid transport
OIO60_RS03595	COG2828	Protein conserved in bacteria
OIO60_RS03600	COG0142	geranyltranstransferase activity
OIO60_RS03605	COG2315	Protein conserved in bacteria
OIO60_RS03620	COG1752	Esterase of the alpha-beta hydrolase superfamily
OIO60_RS03645	COG2194	sulfuric ester hydrolase activity
OIO60_RS03650	COG0745	RESPONSE REGULATOR receiver
OIO60_RS03655	COG0642	Histidine kinase
OIO60_RS03665	COG0004	ammonium transporteR
OIO60_RS03670	COG0583	DNA-binding transcription factor activity
OIO60_RS03690	COG0525	valine-tRNA ligase activity
OIO60_RS03700	COG1028	Short-chain dehydrogenase reductase Sdr
OIO60_RS03710	COG0393	Putative heavy-metal-binding
OIO60_RS03715	COG0393	Putative heavy-metal-binding
OIO60_RS03720	COG1538	Outer membrane efflux protein
OIO60_RS03730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO60_RS03735	COG0671	phosphoesterase, PA-phosphatase related
OIO60_RS03765	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
OIO60_RS03780	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OIO60_RS03780	COG1648	precorrin-2 dehydrogenase activity
OIO60_RS03785	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OIO60_RS03790	COG1733	regulation of RNA biosynthetic process
OIO60_RS03800	COG0531	amino acid
OIO60_RS03815	COG0321	lipoyl(octanoyl) transferase activity
OIO60_RS03820	COG2921	Belongs to the UPF0250 family
OIO60_RS03860	COG2009	succinate dehydrogenase
OIO60_RS03865	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
OIO60_RS03870	COG1053	succinate dehydrogenase
OIO60_RS03875	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OIO60_RS03900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OIO60_RS03920	COG2354	Protein conserved in bacteria
OIO60_RS03925	COG2321	neutral zinc metallopeptidase
OIO60_RS03945	COG2843	Capsule synthesis protein
OIO60_RS03960	COG0589	response to stress
OIO60_RS03980	COG0505	Belongs to the CarA family
OIO60_RS04005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OIO60_RS04010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OIO60_RS04060	COG0477	Major facilitator Superfamily
OIO60_RS04065	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OIO60_RS04080	COG1597	lipid kinase activity
OIO60_RS04085	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
OIO60_RS04110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OIO60_RS04115	COG0584	glycerophosphoryl diester phosphodiesterase
OIO60_RS04135	COG0741	lytic transglycosylase activity
OIO60_RS04155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OIO60_RS04170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO60_RS04200	COG0778	Nitroreductase
OIO60_RS04215	COG1929	Belongs to the glycerate kinase type-1 family
OIO60_RS04220	COG0243	molybdopterin cofactor binding
OIO60_RS04225	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OIO60_RS04230	COG3339	Conserved Protein
OIO60_RS04240	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
OIO60_RS04255	COG1113	amino acid transport
OIO60_RS04265	COG0019	diaminopimelate decarboxylase activity
OIO60_RS04275	COG1280	lysine exporter protein (LysE YggA)
OIO60_RS04280	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OIO60_RS04310	COG0463	Glycosyl transferase, family 2
OIO60_RS04330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO60_RS04365	COG4591	ABC-type transport system involved in lipoprotein release permease component
OIO60_RS04370	COG1136	(ABC) transporter
OIO60_RS04375	COG2333	competence protein COMEC
OIO60_RS04375	COG0658	competence protein
OIO60_RS04385	COG0616	signal peptide processing
OIO60_RS04385	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OIO60_RS04390	COG0596	Alpha beta hydrolase
OIO60_RS04395	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OIO60_RS04405	COG0628	permease
OIO60_RS04440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OIO60_RS04460	COG0823	Involved in the tonB-independent uptake of proteins
OIO60_RS04480	COG0824	Thioesterase
OIO60_RS04485	COG1473	amidohydrolase
OIO60_RS04505	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OIO60_RS04505	COG0047	phosphoribosylformylglycinamidine synthase activity
OIO60_RS04510	COG2814	Major facilitator Superfamily
OIO60_RS04525	COG1024	Enoyl-CoA hydratase
OIO60_RS04530	COG1051	belongs to the nudix hydrolase family
OIO60_RS04530	COG1056	cytidyltransferase-related domain
OIO60_RS04540	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
OIO60_RS04555	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
OIO60_RS04570	COG4625	pathogenesis
OIO60_RS04575	COG0583	DNA-binding transcription factor activity
OIO60_RS04580	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
OIO60_RS04585	COG4208	sulfate ABC transporter
OIO60_RS04590	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
OIO60_RS04600	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
OIO60_RS04605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OIO60_RS04610	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OIO60_RS04630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OIO60_RS04645	COG0681	Belongs to the peptidase S26 family
OIO60_RS04660	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
OIO60_RS04670	COG1381	Involved in DNA repair and RecF pathway recombination
OIO60_RS04675	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
OIO60_RS04685	COG4221	oxidoreductase activity
OIO60_RS04715	COG0436	Aminotransferase
OIO60_RS04735	COG0556	nucleotide-excision repair
OIO60_RS04935	COG5410	chromosome segregation
OIO60_RS05125	COG2070	2-Nitropropane dioxygenase
OIO60_RS05155	COG1215	transferase activity, transferring glycosyl groups
OIO60_RS05170	COG0415	Belongs to the DNA photolyase family
OIO60_RS05180	COG1252	NADH dehydrogenase
OIO60_RS05200	COG1187	pseudouridine synthase activity
OIO60_RS05225	COG0477	Major facilitator Superfamily
OIO60_RS05230	COG0583	DNA-binding transcription factor activity
OIO60_RS05235	COG1823	symporter activity
OIO60_RS05245	COG0612	Peptidase, M16
OIO60_RS05270	COG0352	thiamine-phosphate diphosphorylase activity
OIO60_RS05305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO60_RS05320	COG1309	transcriptional regulator
OIO60_RS05330	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OIO60_RS05335	COG0076	glutamate decarboxylase activity
OIO60_RS05345	COG1522	sequence-specific DNA binding
OIO60_RS05350	COG3961	Belongs to the TPP enzyme family
OIO60_RS05355	COG1113	amino acid transport
OIO60_RS05360	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OIO60_RS05365	COG0573	inorganic phosphate transmembrane transporter activity
OIO60_RS05375	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OIO60_RS05380	COG0616	signal peptide processing
OIO60_RS05415	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
OIO60_RS05420	COG1686	Belongs to the peptidase S11 family
OIO60_RS05445	COG0583	DNA-binding transcription factor activity
OIO60_RS05450	COG1067	ATP-dependent peptidase activity
OIO60_RS05495	COG1966	Carbon starvation protein
OIO60_RS05500	COG2879	small protein
OIO60_RS05535	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
OIO60_RS05535	COG2508	Transcriptional regulator
OIO60_RS05555	COG1113	amino acid transport
OIO60_RS05560	COG0583	DNA-binding transcription factor activity
OIO60_RS05565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OIO60_RS05570	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OIO60_RS05580	COG1012	belongs to the aldehyde dehydrogenase family
OIO60_RS05590	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO60_RS05595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OIO60_RS05595	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
OIO60_RS05630	COG2814	Major facilitator Superfamily
OIO60_RS05635	COG4948	Mandelate Racemase Muconate Lactonizing
OIO60_RS05645	COG1309	transcriptional regulator
OIO60_RS05665	COG1741	Belongs to the pirin family
OIO60_RS05675	COG2964	Protein conserved in bacteria
OIO60_RS05690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO60_RS05700	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OIO60_RS05705	COG4605	iron ion homeostasis
OIO60_RS05710	COG4604	ABC transporter, ATP-binding protein
OIO60_RS05715	COG4607	ABC-type enterochelin transport system periplasmic component
OIO60_RS05720	COG4774	siderophore transport
OIO60_RS05730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO60_RS05735	COG1021	2,3-dihydroxybenzoate-AMP ligase
OIO60_RS05740	COG1535	isochorismatase
OIO60_RS05740	COG3433	isochorismatase activity
OIO60_RS05755	COG1132	(ABC) transporter
OIO60_RS05760	COG1132	(ABC) transporter
OIO60_RS05765	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
OIO60_RS05775	COG1169	isochorismate synthase
OIO60_RS05790	COG3739	integral membrane protein
OIO60_RS05810	COG0302	gtp cyclohydrolase
OIO60_RS05820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
OIO60_RS05850	COG0308	aminopeptidase N
OIO60_RS05855	COG0512	Glutamine amidotransferase of anthranilate synthase
OIO60_RS06015	COG5410	chromosome segregation
OIO60_RS06220	COG0582	viral genome integration into host DNA
OIO60_RS06235	COG0174	glutamine synthetase
OIO60_RS06245	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
OIO60_RS06280	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OIO60_RS06285	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
OIO60_RS06290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OIO60_RS06310	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OIO60_RS06315	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
OIO60_RS06320	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
OIO60_RS06335	COG1960	acyl-CoA dehydrogenase activity
OIO60_RS06340	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OIO60_RS06345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OIO60_RS06355	COG2223	nitrite transmembrane transporter activity
OIO60_RS06365	COG0024	Methionine aminopeptidase
OIO60_RS06370	COG0052	Belongs to the universal ribosomal protein uS2 family
OIO60_RS06385	COG2207	Transcriptional regulator
OIO60_RS06410	COG2951	lytic endotransglycosylase activity
OIO60_RS06415	COG0772	Belongs to the SEDS family
OIO60_RS06430	COG0842	Transport permease protein
OIO60_RS06435	COG1131	(ABC) transporter
OIO60_RS06480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO60_RS06505	COG4215	(ABC) transporter
OIO60_RS06510	COG4160	amino acid transport
OIO60_RS06515	COG4598	ABC transporter
OIO60_RS06525	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OIO60_RS06530	COG0826	peptidase U32
OIO60_RS06535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO60_RS06550	COG1720	tRNA m6t6A37 methyltransferase activity
OIO60_RS06560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OIO60_RS06575	COG0642	Histidine kinase
OIO60_RS06585	COG0494	nUDIX hydrolase
OIO60_RS06595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OIO60_RS06600	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OIO60_RS06605	COG3139	Protein of unknown function (DUF1315)
OIO60_RS06610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OIO60_RS06615	COG1301	dicarboxylic acid transport
OIO60_RS06620	COG1960	acyl-CoA dehydrogenase activity
OIO60_RS06625	COG2819	hydrolase of the alpha beta superfamily
OIO60_RS06635	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
OIO60_RS06645	COG2195	Cleaves the N-terminal amino acid of tripeptides
OIO60_RS06650	COG1234	tRNA 3'-trailer cleavage
OIO60_RS06680	COG2363	Small membrane protein
OIO60_RS06705	COG0513	Belongs to the DEAD box helicase family
OIO60_RS06715	COG0778	Nitroreductase
OIO60_RS06745	COG1286	toxin biosynthetic process
OIO60_RS06770	COG4783	chaperone-mediated protein folding
OIO60_RS06775	COG1610	YqeY-like protein
OIO60_RS06875	COG3111	PFAM Bacterial OB fold (BOF) protein
OIO60_RS06900	COG3243	poly(R)-hydroxyalkanoic acid synthase
OIO60_RS06905	COG0786	glutamate:sodium symporter activity
OIO60_RS06915	COG2186	Transcriptional regulator
OIO60_RS06965	COG0477	Major facilitator Superfamily
OIO60_RS06995	COG2985	domain, Protein
OIO60_RS07005	COG2995	paraquat-inducible protein a
OIO60_RS07010	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OIO60_RS07010	COG3008	intermembrane lipid transfer
OIO60_RS07020	COG1794	racemase activity, acting on amino acids and derivatives
OIO60_RS07050	COG1301	dicarboxylic acid transport
OIO60_RS07060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OIO60_RS07065	COG2011	ABC-type metal ion transport system permease component
OIO60_RS07070	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OIO60_RS07075	COG1464	Belongs to the NlpA lipoprotein family
OIO60_RS07080	COG0151	Belongs to the GarS family
OIO60_RS07085	COG0138	bifunctional purine biosynthesis protein purh
OIO60_RS07090	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
OIO60_RS07120	COG2308	Evidence 4 Homologs of previously reported genes of
OIO60_RS07130	COG1305	Transglutaminase-like
OIO60_RS07140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OIO60_RS07145	COG0305	Participates in initiation and elongation during chromosome replication
OIO60_RS07170	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
OIO60_RS07180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OIO60_RS07185	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OIO60_RS07210	COG1649	PFAM Uncharacterised BCR, COG1649
OIO60_RS07210	COG0726	polysaccharide deacetylase
OIO60_RS07215	COG1215	transferase activity, transferring glycosyl groups
OIO60_RS07220	COG3658	cytochrome
OIO60_RS07230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OIO60_RS07245	COG0583	DNA-binding transcription factor activity
OIO60_RS07265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO60_RS07270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO60_RS07285	COG1960	acyl-CoA dehydrogenase activity
OIO60_RS07290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OIO60_RS07295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO60_RS07320	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
OIO60_RS07325	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
OIO60_RS07335	COG2205	protein histidine kinase activity
OIO60_RS07340	COG0745	RESPONSE REGULATOR receiver
OIO60_RS07345	COG0174	glutamine synthetase
OIO60_RS07365	COG0729	surface antigen
OIO60_RS07390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OIO60_RS07395	COG2814	Major facilitator Superfamily
OIO60_RS07410	COG0583	DNA-binding transcription factor activity
OIO60_RS07425	COG1187	pseudouridine synthase activity
OIO60_RS07445	COG0802	atpase or kinase
OIO60_RS07450	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OIO60_RS07460	COG1923	regulation of RNA biosynthetic process
OIO60_RS07465	COG0697	spore germination
OIO60_RS07480	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OIO60_RS07490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OIO60_RS07495	COG0519	Catalyzes the synthesis of GMP from XMP
OIO60_RS07495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OIO60_RS07500	COG4302	ethanolamine ammonia-lyase activity
OIO60_RS07505	COG4303	Ethanolamine ammonia lyase large subunit
OIO60_RS07510	COG0531	amino acid
OIO60_RS07530	COG1454	alcohol dehydrogenase
OIO60_RS07535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OIO60_RS07545	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
OIO60_RS07565	COG0308	aminopeptidase N
OIO60_RS07575	COG4221	oxidoreductase activity
OIO60_RS07585	COG1605	Chorismate mutase
OIO60_RS07605	COG1309	transcriptional regulator
OIO60_RS07615	COG0668	transmembrane transport
OIO60_RS07645	COG4773	Receptor
OIO60_RS07665	COG0488	(ABC) transporter
OIO60_RS07670	COG0589	response to stress
OIO60_RS07695	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
OIO60_RS07705	COG3135	benzoate transporter
OIO60_RS07710	COG1522	sequence-specific DNA binding
OIO60_RS07720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OIO60_RS07725	COG0583	DNA-binding transcription factor activity
OIO60_RS07735	COG0183	Belongs to the thiolase family
OIO60_RS07745	COG2030	dehydratase
OIO60_RS07750	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OIO60_RS07765	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OIO60_RS07775	COG0824	Thioesterase
OIO60_RS07780	COG1454	alcohol dehydrogenase
OIO60_RS07790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OIO60_RS07810	COG0069	glutamate synthase activity
OIO60_RS07975	COG5410	chromosome segregation
OIO60_RS08180	COG2814	Major facilitator Superfamily
OIO60_RS08195	COG0511	ligase activity, forming carbon-carbon bonds
OIO60_RS08215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO60_RS08215	COG1116	anion transmembrane transporter activity
OIO60_RS08220	COG0745	RESPONSE REGULATOR receiver
OIO60_RS08230	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO60_RS08230	COG2146	nitrite reductase [NAD(P)H] activity
OIO60_RS08235	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO60_RS08240	COG0243	molybdopterin cofactor binding
OIO60_RS08250	COG0243	molybdopterin cofactor binding
OIO60_RS08255	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
OIO60_RS08270	COG0521	Mo-molybdopterin cofactor biosynthetic process
OIO60_RS08270	COG0315	cyclic pyranopterin monophosphate synthase activity
OIO60_RS08275	COG0303	'Molybdopterin
OIO60_RS08285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO60_RS08290	COG0697	spore germination
OIO60_RS08310	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
OIO60_RS08315	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OIO60_RS08370	COG2204	response regulator
OIO60_RS08375	COG3852	Histidine kinase
OIO60_RS08395	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OIO60_RS08400	COG0575	Belongs to the CDS family
OIO60_RS08435	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OIO60_RS08450	COG2137	regulation of response to DNA damage stimulus
OIO60_RS08460	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
OIO60_RS08465	COG1011	Hydrolase
OIO60_RS08475	COG3121	Chaperone
OIO60_RS08480	COG3539	Fimbrial protein
OIO60_RS08505	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OIO60_RS08505	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
OIO60_RS08555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
OIO60_RS08565	COG2353	YceI-like domain
OIO60_RS08575	COG3698	Phosphodiester glycosidase
OIO60_RS08590	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
OIO60_RS08595	COG0506	proline dehydrogenase activity
OIO60_RS08595	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
OIO60_RS08595	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
OIO60_RS08605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OIO60_RS08610	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
OIO60_RS08630	COG1132	(ABC) transporter
OIO60_RS08635	COG3122	Protein conserved in bacteria
OIO60_RS08640	COG3619	membrane
OIO60_RS08650	COG0640	Transcriptional regulator
OIO60_RS08660	COG2850	peptidyl-arginine hydroxylation
OIO60_RS08665	COG0424	maF-like protein
OIO60_RS08685	COG0191	fructose-bisphosphate aldolase activity
OIO60_RS08690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OIO60_RS08705	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
OIO60_RS08715	COG1192	Involved in chromosome partitioning
OIO60_RS08720	COG1475	DNA binding
OIO60_RS08725	COG0811	peptide transport
OIO60_RS08735	COG1132	(ABC) transporter
OIO60_RS08740	COG1663	tetraacyldisaccharide 4'-kinase activity
OIO60_RS08760	COG0084	hydrolase, TatD family'
OIO60_RS08825	COG0776	regulation of translation
OIO60_RS08855	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
OIO60_RS08860	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OIO60_RS08910	COG0339	signal peptide processing
OIO60_RS08920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OIO60_RS08955	COG0702	epimerase
OIO60_RS08960	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OIO60_RS08980	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OIO60_RS09010	COG0316	Belongs to the HesB IscA family
OIO60_RS09015	COG0822	iron-sulfur transferase activity
OIO60_RS09040	COG0776	regulation of translation
OIO60_RS09045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OIO60_RS09050	COG2207	Transcriptional regulator
OIO60_RS09070	COG1960	acyl-CoA dehydrogenase activity
OIO60_RS09075	COG1960	acyl-CoA dehydrogenase activity
OIO60_RS09090	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OIO60_RS09110	COG4264	IucA IucC family
OIO60_RS09115	COG4264	IucA IucC family
OIO60_RS09155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OIO60_RS09170	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
OIO60_RS09190	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OIO60_RS09195	COG0730	response to heat
OIO60_RS09215	COG4773	Receptor
OIO60_RS09220	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OIO60_RS09235	COG1131	(ABC) transporter
OIO60_RS09240	COG0842	Transport permease protein
OIO60_RS09245	COG0842	Transport permease protein
OIO60_RS09300	COG2226	methyltransferase
OIO60_RS09325	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OIO60_RS09360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OIO60_RS09370	COG0133	tryptophan synthase activity
OIO60_RS09385	COG3706	GGDEF domain
OIO60_RS09400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OIO60_RS09405	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
OIO60_RS09410	COG0022	dehydrogenase e1 component
OIO60_RS09415	COG0508	dehydrogenase complex catalyzes the overall conversion of
OIO60_RS09420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OIO60_RS09430	COG1063	alcohol dehydrogenase
OIO60_RS09435	COG3781	membrane
OIO60_RS09445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OIO60_RS09445	COG3453	Protein conserved in bacteria
OIO60_RS09460	COG0730	response to heat
OIO60_RS09475	COG3708	Transcriptional regulator
OIO60_RS09475	COG2207	Transcriptional regulator
OIO60_RS09480	COG1733	regulation of RNA biosynthetic process
OIO60_RS09485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
OIO60_RS09495	COG2188	Transcriptional regulator
OIO60_RS09510	COG4521	taurine ABC transporter
OIO60_RS09515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO60_RS09535	COG0477	Major facilitator Superfamily
OIO60_RS09545	COG1027	Aspartate ammonia-lyase
OIO60_RS09560	COG0583	DNA-binding transcription factor activity
OIO60_RS09565	COG0583	DNA-binding transcription factor activity
OIO60_RS09570	COG0183	Belongs to the thiolase family
OIO60_RS09575	COG2031	fatty acid transporter
OIO60_RS09580	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OIO60_RS09590	COG0583	DNA-binding transcription factor activity
OIO60_RS09600	COG2610	gluconate transmembrane transporter activity
OIO60_RS09605	COG1028	Short-chain dehydrogenase reductase Sdr
OIO60_RS09615	COG2207	Transcriptional regulator
OIO60_RS09630	COG1028	Short-chain dehydrogenase reductase Sdr
OIO60_RS09655	COG0543	2 iron, 2 sulfur cluster binding
OIO60_RS09655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO60_RS09660	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
OIO60_RS09665	COG4638	Rieske (2fe-2S)
OIO60_RS09675	COG0725	ABC transporter, periplasmic molybdate-binding protein
OIO60_RS09680	COG4149	molybdate abc transporter
OIO60_RS09685	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
OIO60_RS09690	COG1028	Short-chain dehydrogenase reductase Sdr
OIO60_RS09695	COG1535	isochorismatase
OIO60_RS09695	COG3433	isochorismatase activity
OIO60_RS09755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OIO60_RS09770	COG0753	catalase activity
OIO60_RS09780	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
OIO60_RS09810	COG3539	Fimbrial protein
OIO60_RS09830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OIO60_RS09850	COG2072	flavoprotein involved in K transport
OIO60_RS09860	COG1538	Outer membrane efflux protein
OIO60_RS09865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OIO60_RS09870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO60_RS09875	COG0745	RESPONSE REGULATOR receiver
OIO60_RS09880	COG2205	protein histidine kinase activity
OIO60_RS09890	COG2207	Transcriptional regulator
OIO60_RS09905	COG1028	Short-chain dehydrogenase reductase Sdr
OIO60_RS09955	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
OIO60_RS10075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OIO60_RS10095	COG1120	ATPase activity
OIO60_RS10100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OIO60_RS10110	COG1064	alcohol dehydrogenase
OIO60_RS10125	COG2207	Transcriptional regulator
OIO60_RS10130	COG2084	Dehydrogenase
OIO60_RS10140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OIO60_RS10145	COG0583	DNA-binding transcription factor activity
OIO60_RS10155	COG0129	dihydroxy-acid dehydratase activity
OIO60_RS10160	COG1012	belongs to the aldehyde dehydrogenase family
OIO60_RS10175	COG1566	PFAM secretion protein HlyD family protein
OIO60_RS10210	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OIO60_RS10240	COG0583	DNA-binding transcription factor activity
OIO60_RS10255	COG2188	Transcriptional regulator
OIO60_RS10285	COG3210	domain, Protein
OIO60_RS10290	COG2831	hemolysin activation secretion protein
OIO60_RS10300	COG1473	amidohydrolase
OIO60_RS10310	COG0475	glutathione-regulated potassium exporter activity
OIO60_RS10310	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OIO60_RS10320	COG0583	DNA-binding transcription factor activity
OIO60_RS10330	COG1335	isochorismatase
OIO60_RS10340	COG1309	transcriptional regulator
OIO60_RS10370	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
OIO60_RS10380	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO60_RS10380	COG1902	pentaerythritol trinitrate reductase activity
OIO60_RS10385	COG1846	Transcriptional regulator
OIO60_RS10405	COG0753	catalase activity
OIO60_RS10420	COG1012	belongs to the aldehyde dehydrogenase family
OIO60_RS10435	COG3162	membrane
OIO60_RS10445	COG3829	transcription factor binding
OIO60_RS10450	COG1028	Short-chain dehydrogenase reductase Sdr
OIO60_RS10455	COG1960	acyl-CoA dehydrogenase activity
OIO60_RS10475	COG1012	belongs to the aldehyde dehydrogenase family
OIO60_RS10495	COG2186	Transcriptional regulator
OIO60_RS10505	COG0583	DNA-binding transcription factor activity
OIO60_RS10510	COG4948	Mandelate Racemase Muconate Lactonizing
OIO60_RS10515	COG4829	muconolactone delta-isomerase
OIO60_RS10525	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
OIO60_RS10530	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OIO60_RS10535	COG0183	Belongs to the thiolase family
OIO60_RS10540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OIO60_RS10550	COG1012	belongs to the aldehyde dehydrogenase family
OIO60_RS10560	COG3733	amine oxidase
OIO60_RS10570	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO60_RS10580	COG1028	Short-chain dehydrogenase reductase Sdr
OIO60_RS10590	COG4638	Rieske (2fe-2S)
OIO60_RS10610	COG0154	amidase activity
OIO60_RS10620	COG2814	Major facilitator Superfamily
OIO60_RS10645	COG1960	acyl-CoA dehydrogenase activity
OIO60_RS10650	COG0583	DNA-binding transcription factor activity
OIO60_RS10655	COG1414	Transcriptional regulator
OIO60_RS10670	COG2391	methyltransferase activity
OIO60_RS10680	COG4993	Dehydrogenase
OIO60_RS10685	COG3659	wide pore channel activity
OIO60_RS10690	COG3420	alginic acid biosynthetic process
OIO60_RS10695	COG0710	3-dehydroquinate dehydratase activity
OIO60_RS10700	COG3485	protocatechuate 3,4-dioxygenase
OIO60_RS10705	COG3485	protocatechuate 3,4-dioxygenase
OIO60_RS10710	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OIO60_RS10715	COG2271	Major facilitator Superfamily
OIO60_RS10720	COG0596	Alpha beta hydrolase
OIO60_RS10725	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OIO60_RS10730	COG0183	Belongs to the thiolase family
OIO60_RS10735	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OIO60_RS10740	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
OIO60_RS10750	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
OIO60_RS10755	COG2323	membrane
OIO60_RS10800	COG1902	pentaerythritol trinitrate reductase activity
OIO60_RS10800	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO60_RS10825	COG0542	response to heat
OIO60_RS10830	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
OIO60_RS10860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OIO60_RS10865	COG0569	domain protein
OIO60_RS10870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OIO60_RS10885	COG4774	siderophore transport
OIO60_RS10890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OIO60_RS10900	COG1585	Membrane protein implicated in regulation of membrane protease activity
OIO60_RS10915	COG1294	oxidase, subunit
OIO60_RS10920	COG4890	Cyd operon protein YbgT
OIO60_RS10935	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
OIO60_RS10945	COG0552	protein localization to endoplasmic reticulum
OIO60_RS10970	COG0516	GMP reductase activity
OIO60_RS10970	COG0517	IMP dehydrogenase activity
OIO60_RS10975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OIO60_RS10980	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
OIO60_RS10990	COG0583	DNA-binding transcription factor activity
OIO60_RS10995	COG0024	Methionine aminopeptidase
OIO60_RS11025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OIO60_RS11025	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OIO60_RS11030	COG1105	Belongs to the carbohydrate kinase PfkB family
OIO60_RS11035	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
OIO60_RS11035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OIO60_RS11035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OIO60_RS11070	COG3173	Aminoglycoside phosphotransferase
OIO60_RS11080	COG2433	Pfam Transposase IS66
OIO60_RS11105	COG2135	peptidase activity
OIO60_RS11150	COG0697	spore germination
OIO60_RS11160	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
OIO60_RS11170	COG0583	DNA-binding transcription factor activity
OIO60_RS11190	COG1309	transcriptional regulator
OIO60_RS11205	COG1522	sequence-specific DNA binding
OIO60_RS11215	COG1126	abc transporter atp-binding protein
OIO60_RS11220	COG0765	amino acid transport
OIO60_RS11225	COG0765	amino acid transport
OIO60_RS11255	COG1464	Belongs to the NlpA lipoprotein family
OIO60_RS11265	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OIO60_RS11270	COG2011	ABC-type metal ion transport system permease component
OIO60_RS11275	COG0012	GTP binding
OIO60_RS11300	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
OIO60_RS11340	COG0386	Belongs to the glutathione peroxidase family
OIO60_RS11350	COG0436	Aminotransferase
OIO60_RS11390	COG3634	alkyl hydroperoxide reductase activity
OIO60_RS11405	COG0583	DNA-binding transcription factor activity
OIO60_RS11410	COG0798	PFAM Bile acid sodium symporter
OIO60_RS11415	COG0640	Transcriptional regulator
OIO60_RS11430	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
OIO60_RS11440	COG0583	DNA-binding transcription factor activity
OIO60_RS11450	COG1953	Uracil, thiamine, allantoin
OIO60_RS11460	COG2175	clavaminate synthase activity
OIO60_RS11465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO60_RS11470	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
OIO60_RS11475	COG4521	taurine ABC transporter
OIO60_RS11485	COG0477	Major facilitator Superfamily
OIO60_RS11505	COG1271	oxidase subunit
OIO60_RS11510	COG1294	oxidase, subunit
OIO60_RS11520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO60_RS11540	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
OIO60_RS11560	COG3052	prosthetic group binding
OIO60_RS11565	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
OIO60_RS11575	COG2814	Major facilitator Superfamily
OIO60_RS11595	COG1346	cytolysis
OIO60_RS11605	COG0583	DNA-binding transcription factor activity
OIO60_RS11610	COG0625	glutathione transferase activity
OIO60_RS11615	COG0625	glutathione transferase activity
OIO60_RS11620	COG0583	DNA-binding transcription factor activity
OIO60_RS11635	COG1045	serine acetyltransferase
OIO60_RS11640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OIO60_RS11645	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OIO60_RS11670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OIO60_RS11675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OIO60_RS11680	COG1126	abc transporter atp-binding protein
OIO60_RS11685	COG0765	amino acid transport
OIO60_RS11690	COG0765	amino acid transport
OIO60_RS11710	COG2205	protein histidine kinase activity
OIO60_RS11710	COG0784	Response regulator, receiver
OIO60_RS11730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OIO60_RS11750	COG1028	Short-chain dehydrogenase reductase Sdr
OIO60_RS11800	COG0583	DNA-binding transcription factor activity
OIO60_RS11820	COG0318	PFAM AMP-dependent synthetase and ligase
OIO60_RS11825	COG1309	transcriptional regulator
OIO60_RS11830	COG1960	acyl-CoA dehydrogenase activity
OIO60_RS11835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OIO60_RS11840	COG1024	Enoyl-CoA hydratase
OIO60_RS11845	COG4770	biotin carboxylase activity
OIO60_RS11855	COG0583	DNA-binding transcription factor activity
OIO60_RS11870	COG1960	acyl-CoA dehydrogenase activity
OIO60_RS11880	COG2814	Major facilitator Superfamily
OIO60_RS11890	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OIO60_RS11895	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
OIO60_RS11900	COG2814	Major facilitator Superfamily
OIO60_RS11905	COG1960	acyl-CoA dehydrogenase activity
OIO60_RS11910	COG1024	Enoyl-CoA hydratase
OIO60_RS11915	COG1028	Short-chain dehydrogenase reductase Sdr
OIO60_RS11920	COG1250	3-hydroxyacyl-CoA dehydrogenase
OIO60_RS11925	COG0183	Belongs to the thiolase family
OIO60_RS11935	COG2814	Major facilitator Superfamily
OIO60_RS11945	COG1024	Enoyl-CoA hydratase
OIO60_RS11960	COG1960	acyl-CoA dehydrogenase activity
OIO60_RS11965	COG2814	Major facilitator Superfamily
OIO60_RS11970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OIO60_RS11975	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
OIO60_RS11990	COG3842	ATPase activity
OIO60_RS11995	COG1840	ABC-type Fe3 transport system, periplasmic component
OIO60_RS12005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO60_RS12010	COG1414	Transcriptional regulator
OIO60_RS12020	COG0583	DNA-binding transcription factor activity
OIO60_RS12025	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OIO60_RS12030	COG1012	belongs to the aldehyde dehydrogenase family
OIO60_RS12040	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
OIO60_RS12050	COG1012	belongs to the aldehyde dehydrogenase family
OIO60_RS12055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OIO60_RS12060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO60_RS12065	COG2267	carboxylic ester hydrolase activity
OIO60_RS12085	COG3038	cytochrome b561
OIO60_RS12090	COG0753	catalase activity
OIO60_RS12120	COG2050	protein possibly involved in aromatic compounds catabolism
OIO60_RS12130	COG3327	negative regulation of DNA-templated transcription, initiation
OIO60_RS12135	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
OIO60_RS12140	COG0183	Belongs to the thiolase family
OIO60_RS12145	COG1250	3-hydroxyacyl-CoA dehydrogenase
OIO60_RS12150	COG1024	Enoyl-CoA hydratase
OIO60_RS12155	COG1024	Enoyl-CoA hydratase
OIO60_RS12160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO60_RS12165	COG2151	metal-sulfur cluster biosynthetic enzyme
OIO60_RS12170	COG3396	Phenylacetate-CoA oxygenase
OIO60_RS12175	COG3460	Phenylacetate-CoA oxygenase
OIO60_RS12180	COG3396	Phenylacetate-CoA oxygenase
OIO60_RS12185	COG1012	belongs to the aldehyde dehydrogenase family
OIO60_RS12185	COG2030	dehydratase
OIO60_RS12190	COG1760	l-serine dehydratase
OIO60_RS12195	COG0531	amino acid
OIO60_RS12200	COG1012	belongs to the aldehyde dehydrogenase family
OIO60_RS12215	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO60_RS12225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OIO60_RS12245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OIO60_RS12255	COG0789	Transcriptional regulator
OIO60_RS12270	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
OIO60_RS12285	COG2807	transmembrane transport
OIO60_RS12290	COG0590	tRNA wobble adenosine to inosine editing
OIO60_RS12405	COG1116	anion transmembrane transporter activity
OIO60_RS12410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OIO60_RS12420	COG0864	Transcriptional regulator
OIO60_RS12440	COG2249	NAD(P)H dehydrogenase (quinone) activity
OIO60_RS12445	COG0439	Biotin carboxylase
OIO60_RS12460	COG1063	alcohol dehydrogenase
OIO60_RS12470	COG1309	transcriptional regulator
OIO60_RS12490	COG0038	chloride channel
OIO60_RS12495	COG4770	biotin carboxylase activity
OIO60_RS12515	COG1914	H( )-stimulated, divalent metal cation uptake system
OIO60_RS12520	COG0583	DNA-binding transcription factor activity
OIO60_RS12570	COG1250	3-hydroxyacyl-CoA dehydrogenase
OIO60_RS12590	COG2814	Major facilitator Superfamily
OIO60_RS12605	COG1560	Kdo2-lipid A biosynthetic process
OIO60_RS12615	COG5006	permease, DMT superfamily
OIO60_RS12620	COG1522	sequence-specific DNA binding
OIO60_RS12635	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
OIO60_RS12645	COG4122	O-methyltransferase activity
OIO60_RS12675	COG1538	Outer membrane efflux protein
OIO60_RS12680	COG1137	ATPase activity
OIO60_RS12685	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
OIO60_RS12695	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
OIO60_RS12700	COG0517	IMP dehydrogenase activity
OIO60_RS12700	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
OIO60_RS12735	COG2814	Major facilitator Superfamily
OIO60_RS12770	COG1278	Cold shock
OIO60_RS12775	COG1280	lysine exporter protein (LysE YggA)
OIO60_RS12805	COG1570	exodeoxyribonuclease VII activity
OIO60_RS12855	COG0583	DNA-binding transcription factor activity
OIO60_RS12865	COG4638	Rieske (2fe-2S)
OIO60_RS12870	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
OIO60_RS12875	COG0543	2 iron, 2 sulfur cluster binding
OIO60_RS12875	COG0633	Ferredoxin
OIO60_RS12880	COG1028	Short-chain dehydrogenase reductase Sdr
OIO60_RS12885	COG3135	benzoate transporter
OIO60_RS12890	COG2814	Major facilitator Superfamily
OIO60_RS12905	COG1643	Atp-dependent helicase
OIO60_RS12910	COG0450	alkyl hydroperoxide reductase
OIO60_RS12920	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
OIO60_RS12930	COG3634	alkyl hydroperoxide reductase activity
OIO60_RS12950	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OIO60_RS12955	COG0625	glutathione transferase activity
OIO60_RS12965	COG2885	chlorophyll binding
OIO60_RS13000	COG0542	response to heat
OIO60_RS13015	COG1765	OsmC-like protein
OIO60_RS13030	COG0667	Aldo Keto reductase
OIO60_RS13045	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OIO60_RS13055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OIO60_RS13065	COG0527	aspartate kinase activity
OIO60_RS13075	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
OIO60_RS13085	COG3038	cytochrome b561
OIO60_RS13090	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
OIO60_RS13095	COG2252	PERMEase
OIO60_RS13105	COG2072	flavoprotein involved in K transport
OIO60_RS13175	COG0589	response to stress
OIO60_RS13180	COG0659	secondary active sulfate transmembrane transporter activity
OIO60_RS13190	COG1002	Type II restriction enzyme, methylase subunits
OIO60_RS13195	COG1061	Type III restriction enzyme res subunit
OIO60_RS13245	COG4269	membrane
OIO60_RS13260	COG1902	pentaerythritol trinitrate reductase activity
OIO60_RS13260	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO60_RS13270	COG3706	GGDEF domain
OIO60_RS13270	COG4251	negative regulation of phosphorylation
OIO60_RS13270	COG5001	Diguanylate cyclase
OIO60_RS13270	COG2203	Gaf domain
OIO60_RS13280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OIO60_RS13310	COG4172	Belongs to the ABC transporter superfamily
OIO60_RS13315	COG4239	(ABC) transporter, permease
OIO60_RS13320	COG4174	ABC transporter (Permease)
OIO60_RS13330	COG0741	lytic transglycosylase activity
OIO60_RS13330	COG0741	lytic transglycosylase activity
OIO60_RS13330	COG1388	LysM domain
OIO60_RS13330	COG1388	LysM domain
OIO60_RS13335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OIO60_RS13375	COG0583	DNA-binding transcription factor activity
OIO60_RS13380	COG1279	arginine transmembrane transporter activity
OIO60_RS13400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO60_RS13405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO60_RS13410	COG0006	proline dipeptidase activity
OIO60_RS13450	COG2194	sulfuric ester hydrolase activity
OIO60_RS13495	COG0739	heme binding
OIO60_RS13820	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OIO60_RS13845	COG3384	dioxygenase
OIO60_RS13880	COG1061	Type III restriction enzyme res subunit
OIO60_RS13885	COG1002	Type II restriction enzyme, methylase subunits
OIO60_RS13895	COG0659	secondary active sulfate transmembrane transporter activity
OIO60_RS13900	COG0589	response to stress
OIO60_RS13945	COG2878	Part of a membrane complex involved in electron transport
OIO60_RS13950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OIO60_RS13975	COG0768	penicillin binding
OIO60_RS13980	COG0742	ribosomal rna small subunit methyltransferase
OIO60_RS13995	COG0830	nickel cation binding
OIO60_RS14005	COG0804	urea catabolic process
OIO60_RS14045	COG1253	flavin adenine dinucleotide binding
OIO60_RS14050	COG2851	Citrate transporter
OIO60_RS14100	COG1773	rubredoxin
OIO60_RS14105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO60_RS14115	COG0583	DNA-binding transcription factor activity
OIO60_RS14140	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
OIO60_RS14145	COG4181	ATPase activity
OIO60_RS14200	COG1262	PFAM Formylglycine-generating sulfatase enzyme
OIO60_RS14220	COG0306	phosphate transporter
OIO60_RS14230	COG3958	Transketolase
OIO60_RS14235	COG3959	Transketolase, thiamine diphosphate binding domain
OIO60_RS14240	COG2271	Major facilitator Superfamily
OIO60_RS14245	COG1028	Short-chain dehydrogenase reductase Sdr
OIO60_RS14250	COG0583	DNA-binding transcription factor activity
OIO60_RS14265	COG2223	nitrite transmembrane transporter activity
OIO60_RS14270	COG2207	Transcriptional regulator
OIO60_RS14275	COG2066	Belongs to the glutaminase family
OIO60_RS14280	COG0242	peptide deformylase activity
OIO60_RS14285	COG0477	Major facilitator Superfamily
OIO60_RS14295	COG0028	Belongs to the TPP enzyme family
OIO60_RS14310	COG1028	Short-chain dehydrogenase reductase Sdr
OIO60_RS14315	COG2267	carboxylic ester hydrolase activity
OIO60_RS14325	COG2271	Major facilitator Superfamily
OIO60_RS14330	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO60_RS14340	COG1028	Short-chain dehydrogenase reductase Sdr
OIO60_RS14360	COG1414	Transcriptional regulator
OIO60_RS14385	COG1215	transferase activity, transferring glycosyl groups
OIO60_RS14390	COG0726	polysaccharide deacetylase
OIO60_RS14390	COG1649	PFAM Uncharacterised BCR, COG1649
OIO60_RS14400	COG4681	YaeQ
OIO60_RS14410	COG0523	cobalamin synthesis protein
OIO60_RS14420	COG1607	acyl-coa hydrolase
OIO60_RS14430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OIO60_RS14435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OIO60_RS14440	COG1309	transcriptional regulator
OIO60_RS14465	COG2040	homocysteine
OIO60_RS14470	COG0531	amino acid
OIO60_RS14525	COG1595	DNA-templated transcription, initiation
OIO60_RS14535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OIO60_RS14540	COG0477	Major facilitator Superfamily
OIO60_RS14605	COG0629	single-stranded DNA binding
OIO60_RS14650	COG0582	viral genome integration into host DNA
OIO60_RS14670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OIO60_RS14755	COG0592	DNA-directed DNA polymerase activity
OIO60_RS14795	COG2026	Addiction module toxin, RelE StbE family
OIO60_RS15015	COG1484	DNA-dependent DNA replication
OIO60_RS15100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OIO60_RS15170	COG0405	Gamma-glutamyltransferase
OIO60_RS15175	COG2814	Major facilitator Superfamily
OIO60_RS15185	COG2050	protein possibly involved in aromatic compounds catabolism
OIO60_RS15200	COG1090	epimerase
OIO60_RS15220	COG0420	3'-5' exonuclease activity
OIO60_RS15245	COG0735	belongs to the Fur family
OIO60_RS15250	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OIO60_RS15270	COG0121	glutamine amidotransferase
OIO60_RS15285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OIO60_RS15295	COG0210	DNA helicase
OIO60_RS15300	COG2885	chlorophyll binding
OIO60_RS15305	COG0204	Acyl-transferase
OIO60_RS15320	COG2894	cell division
OIO60_RS15340	COG1280	lysine exporter protein (LysE YggA)
OIO60_RS15345	COG1674	ftsk spoiiie
OIO60_RS15345	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OIO60_RS15350	COG0492	ferredoxin-NADP+ reductase activity
OIO60_RS15355	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
OIO60_RS15365	COG0456	acetyltransferase
OIO60_RS15410	COG1981	membrane
OIO60_RS15425	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
OIO60_RS15425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OIO60_RS15445	COG1012	belongs to the aldehyde dehydrogenase family
OIO60_RS15455	COG0657	acetylesterase activity
OIO60_RS15465	COG0473	3-isopropylmalate dehydrogenase activity
OIO60_RS15470	COG0583	DNA-binding transcription factor activity
OIO60_RS15490	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OIO60_RS15515	COG0564	pseudouridine synthase activity
OIO60_RS15525	COG0358	DNA primase activity
OIO60_RS15540	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
OIO60_RS15570	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OIO60_RS15600	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OIO60_RS15610	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OIO60_RS15610	COG0352	thiamine-phosphate diphosphorylase activity
OIO60_RS15610	COG0351	phosphomethylpyrimidine kinase
OIO60_RS15615	COG1652	LysM domain
OIO60_RS15640	COG1399	metal-binding, possibly nucleic acid-binding protein
OIO60_RS15645	COG3101	peptidyl-lysine hydroxylation
OIO60_RS15650	COG0009	L-threonylcarbamoyladenylate synthase
OIO60_RS15655	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
OIO60_RS15660	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
OIO60_RS15675	COG4106	trans-aconitate 2-methyltransferase activity
OIO60_RS15690	COG0596	Alpha beta hydrolase
OIO60_RS15690	COG2226	methyltransferase
OIO60_RS15690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OIO60_RS15695	COG1877	trehalose-phosphatase activity
OIO60_RS15700	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
OIO60_RS15705	COG2223	nitrite transmembrane transporter activity
OIO60_RS15725	COG1196	nuclear chromosome segregation
OIO60_RS15735	COG0730	response to heat
OIO60_RS15750	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OIO60_RS15760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OIO60_RS15810	COG0489	protein tyrosine kinase activity
OIO60_RS15820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OIO60_RS15820	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OIO60_RS15850	COG2515	1-aminocyclopropane-1-carboxylate deaminase
OIO60_RS15855	COG2081	HI0933 family
OIO60_RS15865	COG0668	transmembrane transport
OIO60_RS15885	COG0583	DNA-binding transcription factor activity
OIO60_RS15905	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OIO60_RS15910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OIO60_RS15940	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
OIO60_RS15980	COG0745	RESPONSE REGULATOR receiver
OIO60_RS16000	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OIO60_RS16010	COG2205	protein histidine kinase activity
OIO60_RS16080	COG4993	Dehydrogenase
OIO60_RS16105	COG0384	phenazine biosynthesis protein PhzF
OIO60_RS16130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO60_RS16145	COG0583	DNA-binding transcription factor activity
OIO60_RS16175	COG0583	DNA-binding transcription factor activity
OIO60_RS16190	COG0583	DNA-binding transcription factor activity
OIO60_RS16195	COG1053	succinate dehydrogenase
OIO60_RS16205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OIO60_RS16210	COG2814	Major facilitator Superfamily
OIO60_RS16215	COG1960	acyl-CoA dehydrogenase activity
OIO60_RS16220	COG0583	DNA-binding transcription factor activity
OIO60_RS16225	COG1063	alcohol dehydrogenase
OIO60_RS16255	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
OIO60_RS16260	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
OIO60_RS16265	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OIO60_RS16280	COG3667	copper resistance
OIO60_RS16285	COG2132	Multicopper oxidase
OIO60_RS16295	COG0561	phosphatase activity
OIO60_RS16300	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OIO60_RS16325	COG1214	PFAM Peptidase M22, glycoprotease
OIO60_RS16375	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
OIO60_RS16385	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OIO60_RS16390	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OIO60_RS16395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OIO60_RS16465	COG1846	Transcriptional regulator
OIO60_RS16470	COG1764	response to oxidative stress
OIO60_RS16510	COG0037	tRNA processing
OIO60_RS16520	COG0248	Ppx GppA phosphatase
OIO60_RS16550	COG0072	phenylalanine-tRNA ligase activity
OIO60_RS16595	COG1238	metal cluster binding
OIO60_RS16600	COG0625	glutathione transferase activity
OIO60_RS16615	COG0318	PFAM AMP-dependent synthetase and ligase
OIO60_RS16620	COG3028	Belongs to the UPF0307 family
OIO60_RS16625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OIO60_RS16645	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OIO60_RS16650	COG0617	tRNA 3'-terminal CCA addition
OIO60_RS16655	COG1555	photosystem II stabilization
OIO60_RS16660	COG3956	TIGRFAM MazG family protein
OIO60_RS16670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OIO60_RS16690	COG2205	protein histidine kinase activity
OIO60_RS16690	COG0784	Response regulator, receiver
OIO60_RS16690	COG5002	protein histidine kinase activity
OIO60_RS16695	COG1024	Enoyl-CoA hydratase
OIO60_RS16700	COG2084	Dehydrogenase
OIO60_RS16705	COG3622	Belongs to the hyi family
OIO60_RS16735	COG0697	spore germination
OIO60_RS16745	COG2814	Major facilitator Superfamily
OIO60_RS16750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OIO60_RS16760	COG0583	DNA-binding transcription factor activity
OIO60_RS16770	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
OIO60_RS16785	COG0084	hydrolase, TatD family'
OIO60_RS16800	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OIO60_RS16830	COG0440	acetolactate synthase activity
OIO60_RS16835	COG0028	Belongs to the TPP enzyme family
OIO60_RS16860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO60_RS16865	COG0577	efflux transmembrane transporter activity
OIO60_RS16865	COG1136	(ABC) transporter
OIO60_RS16870	COG1538	Outer membrane efflux protein
OIO60_RS16885	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
OIO60_RS16890	COG1162	GTPase activity
OIO60_RS16900	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OIO60_RS16920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OIO60_RS16925	COG1028	Short-chain dehydrogenase reductase Sdr
OIO60_RS16965	COG2986	histidine ammonia-lyase
OIO60_RS16980	COG0318	PFAM AMP-dependent synthetase and ligase
OIO60_RS16990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OIO60_RS17035	COG1426	Protein conserved in bacteria
OIO60_RS17070	COG0793	Belongs to the peptidase S41A family
OIO60_RS17085	COG2267	carboxylic ester hydrolase activity
OIO60_RS17100	COG3265	gluconokinase activity
OIO60_RS17110	COG0800	Aldolase
OIO60_RS17120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OIO60_RS17125	COG0280	phosphate acetyltransferase
OIO60_RS17125	COG0857	belongs to the CobB CobQ family
OIO60_RS17130	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
OIO60_RS17130	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
OIO60_RS17150	COG0740	serine-type endopeptidase activity
OIO60_RS17160	COG4774	siderophore transport
OIO60_RS17170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OIO60_RS17180	COG2813	Specifically methylates the guanine in position
OIO60_RS17180	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OIO60_RS17280	COG0788	formyltetrahydrofolate deformylase activity
OIO60_RS17305	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OIO60_RS17305	COG4651	solute:proton antiporter activity
OIO60_RS17325	COG0724	RNA recognition motif
OIO60_RS17330	COG0210	DNA helicase
OIO60_RS17355	COG1733	regulation of RNA biosynthetic process
OIO60_RS17365	COG2900	Belongs to the SlyX family
OIO60_RS17370	COG0488	(ABC) transporter
OIO60_RS17375	COG1280	lysine exporter protein (LysE YggA)
OIO60_RS17380	COG1560	Kdo2-lipid A biosynthetic process
OIO60_RS17390	COG1301	dicarboxylic acid transport
OIO60_RS17445	COG0473	3-isopropylmalate dehydrogenase activity
OIO60_RS17510	COG0583	DNA-binding transcription factor activity
OIO60_RS17520	COG0625	glutathione transferase activity
OIO60_RS17525	COG2378	regulation of single-species biofilm formation
OIO60_RS17530	COG0546	phosphoglycolate phosphatase activity
OIO60_RS17540	COG1530	ribonuclease E activity
OIO60_RS17545	COG0318	PFAM AMP-dependent synthetase and ligase
OIO60_RS17560	COG0583	DNA-binding transcription factor activity
OIO60_RS17565	COG4221	oxidoreductase activity
OIO60_RS17570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OIO60_RS17580	COG0534	Mate efflux family protein
OIO60_RS17595	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OIO60_RS17635	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
OIO60_RS17640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OIO60_RS17655	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
OIO60_RS17665	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
OIO60_RS17665	COG0644	oxidoreductase
OIO60_RS17670	COG0425	Belongs to the sulfur carrier protein TusA family
OIO60_RS17675	COG4535	Mg2 and Co2 transporter CorC
OIO60_RS17685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OIO60_RS17705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OIO60_RS17710	COG0475	glutathione-regulated potassium exporter activity
OIO60_RS17710	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OIO60_RS17715	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
OIO60_RS17725	COG0484	heat shock protein binding
OIO60_RS17730	COG0789	Transcriptional regulator
OIO60_RS17735	COG0598	Magnesium transport protein CorA
OIO60_RS17750	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OIO60_RS17755	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OIO60_RS17760	COG1074	ATP-dependent DNA helicase activity
OIO60_RS17765	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
OIO60_RS17785	COG2226	methyltransferase
OIO60_RS17800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO60_RS17805	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OIO60_RS17820	COG2111	Na H antiporter
OIO60_RS17820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OIO60_RS17825	COG1006	Multisubunit Na H antiporter MnhC subunit
OIO60_RS17830	COG0651	ATP synthesis coupled electron transport
OIO60_RS17835	COG1863	multisubunit Na H antiporter MnhE subunit
OIO60_RS17840	COG2212	antiporter activity
OIO60_RS17845	COG1320	monovalent cation:proton antiporter activity
OIO60_RS17860	COG0195	Participates in both transcription termination and antitermination
OIO60_RS17910	COG0237	dephospho-CoA kinase activity
OIO60_RS17920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OIO60_RS17935	COG0497	DNA recombination
OIO60_RS17945	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
OIO60_RS17975	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OIO60_RS17975	COG2169	Transcriptional regulator
OIO60_RS17980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OIO60_RS18045	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OIO60_RS18060	COG0326	Molecular chaperone. Has ATPase activity
OIO60_RS18075	COG2056	Na+-H+ antiporter family
OIO60_RS18080	COG0596	Alpha beta hydrolase
OIO60_RS18175	COG0546	phosphoglycolate phosphatase activity
OIO60_RS18180	COG1716	ATPase activity
OIO60_RS18225	COG0181	hydroxymethylbilane synthase activity
OIO60_RS18235	COG3275	phosphorelay sensor kinase activity
OIO60_RS18255	COG1538	Outer membrane efflux protein
OIO60_RS18260	COG0697	spore germination
OIO60_RS18285	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
OIO60_RS18290	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
OIO60_RS18295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OIO60_RS18300	COG0772	Belongs to the SEDS family
OIO60_RS18325	COG4974	Belongs to the 'phage' integrase family
OIO60_RS18330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OIO60_RS18340	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
OIO60_RS18350	COG2197	response regulator
OIO60_RS18365	COG0793	Belongs to the peptidase S41A family
OIO60_RS18370	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
OIO60_RS18375	COG0795	lipopolysaccharide-transporting ATPase activity
OIO60_RS18415	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OIO60_RS18415	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OIO60_RS18425	COG0004	ammonium transporteR
OIO60_RS18430	COG0347	Belongs to the P(II) protein family
OIO60_RS18490	COG0659	secondary active sulfate transmembrane transporter activity
OIO60_RS18495	COG0589	response to stress
OIO60_RS18530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO60_RS18540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OIO60_RS18560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
OIO60_RS18575	COG0318	PFAM AMP-dependent synthetase and ligase
OIO60_RS18585	COG0477	Major facilitator Superfamily
OIO60_RS18590	COG2860	membrane
OIO60_RS18600	COG1253	flavin adenine dinucleotide binding
OIO60_RS18620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OIO60_RS18660	COG0655	NAD(P)H dehydrogenase (quinone) activity
OIO60_RS18670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OIO60_RS18740	COG0758	DNA mediated transformation
OIO60_RS18750	COG0697	spore germination
OIO60_RS18755	COG1309	transcriptional regulator
OIO60_RS18770	COG0386	Belongs to the glutathione peroxidase family
OIO60_RS18835	COG1121	(ABC) transporter
OIO60_RS18840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OIO60_RS18845	COG1280	lysine exporter protein (LysE YggA)
OIO60_RS18850	COG2837	iron assimilation
OIO60_RS18860	COG0281	malic enzyme
OIO60_RS18905	COG0519	Catalyzes the synthesis of GMP from XMP
OIO60_RS18905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OIO60_RS18910	COG4399	Belongs to the UPF0754 family
OIO60_RS18915	COG2259	Doxx family
OIO60_RS18920	COG0586	Pfam SNARE associated Golgi protein
OIO60_RS18935	COG1192	Involved in chromosome partitioning
OIO60_RS18945	COG0271	Belongs to the BolA IbaG family
OIO60_RS18965	COG2267	carboxylic ester hydrolase activity
OIO60_RS18985	COG3321	synthase
OIO60_RS18985	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
OIO60_RS18985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OIO60_RS18985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OIO60_RS18990	COG1960	acyl-CoA dehydrogenase activity
OIO60_RS19000	COG2197	response regulator
OIO60_RS19010	COG3916	Acyl-homoserine-lactone synthase
OIO60_RS19015	COG0477	Major facilitator Superfamily
OIO60_RS19020	COG1024	Enoyl-CoA hydratase
OIO60_RS19025	COG1024	Enoyl-CoA hydratase
OIO60_RS19030	COG1960	acyl-CoA dehydrogenase activity
OIO60_RS19035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OIO60_RS19055	COG1113	amino acid transport
OIO60_RS19060	COG1113	amino acid transport
OIO60_RS19065	COG0251	oxidation-reduction process
OIO60_RS19105	COG0564	pseudouridine synthase activity
OIO60_RS19165	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
OIO60_RS19180	COG1802	Transcriptional regulator
OIO60_RS19190	COG1448	Aminotransferase
OIO60_RS19195	COG0277	FAD linked oxidase domain protein
OIO60_RS19205	COG2186	Transcriptional regulator
OIO60_RS19215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OIO60_RS19220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OIO60_RS19235	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OIO60_RS19245	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
OIO60_RS19255	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
OIO60_RS19260	COG0438	transferase activity, transferring glycosyl groups
OIO60_RS19280	COG1216	Glycosyl transferase, family 2
OIO60_RS19285	COG5039	Polysaccharide pyruvyl transferase
OIO60_RS19295	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
OIO60_RS19300	COG1596	polysaccharide export
OIO60_RS19325	COG0728	peptidoglycan biosynthetic process
OIO60_RS19330	COG3023	N-Acetylmuramoyl-L-alanine amidase
OIO60_RS19390	COG0546	phosphoglycolate phosphatase activity
OIO60_RS19395	COG1028	Short-chain dehydrogenase reductase Sdr
OIO60_RS19415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO60_RS19420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO60_RS19425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OIO60_RS19430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO60_RS19435	COG1116	anion transmembrane transporter activity
OIO60_RS19440	COG1309	transcriptional regulator
OIO60_RS19445	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
OIO60_RS19455	COG0196	riboflavin kinase activity
OIO60_RS19460	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OIO60_RS19470	COG1047	Peptidyl-prolyl cis-trans
OIO60_RS19510	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OIO60_RS19515	COG0657	acetylesterase activity
OIO60_RS19535	COG0583	DNA-binding transcription factor activity
OIO60_RS19565	COG2951	lytic endotransglycosylase activity
OIO60_RS19570	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
OIO60_RS19585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OIO60_RS19595	COG0671	phosphoesterase, PA-phosphatase related
OIO60_RS19600	COG0861	Integral membrane protein TerC family
OIO60_RS19610	COG0754	glutathionylspermidine amidase activity
OIO60_RS19620	COG0402	S-adenosylhomocysteine deaminase activity
OIO60_RS19635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OIO60_RS19640	COG1230	cation diffusion facilitator family transporter
OIO60_RS19655	COG0706	membrane insertase activity
OIO60_RS19725	COG1525	nuclease
OIO60_RS19785	COG1475	DNA binding
OIO60_RS19800	COG3853	Toxic anion resistance protein (TelA)
OIO60_RS19885	COG0484	heat shock protein binding
OIO60_RS19970	COG0741	lytic transglycosylase activity
OIO60_RS20005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OIO60_RS20135	COG0627	Serine hydrolase involved in the detoxification of formaldehyde