locus-tag	class	description
OIO47_RS00010	COG0592	DNA-directed DNA polymerase activity
OIO47_RS00020	COG0187	DNA topoisomerase II activity
OIO47_RS00030	COG0586	Pfam SNARE associated Golgi protein
OIO47_RS00035	COG0488	(ABC) transporter
OIO47_RS00060	COG0596	Alpha beta hydrolase
OIO47_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
OIO47_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OIO47_RS00110	COG0733	neurotransmitter:sodium symporter activity
OIO47_RS00150	COG2233	PERMEase
OIO47_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO47_RS00200	COG2814	Major facilitator Superfamily
OIO47_RS00205	COG0656	L-ascorbic acid biosynthetic process
OIO47_RS00210	COG0583	DNA-binding transcription factor activity
OIO47_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO47_RS00230	COG1064	alcohol dehydrogenase
OIO47_RS00235	COG2818	Glycosylase
OIO47_RS00250	COG1194	a g-specific adenine glycosylase
OIO47_RS00270	COG2983	Belongs to the UPF0260 family
OIO47_RS00280	COG3121	Chaperone
OIO47_RS00285	COG3188	usher protein
OIO47_RS00300	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OIO47_RS00305	COG2116	formate transmembrane transporter activity
OIO47_RS00325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OIO47_RS00330	COG1335	isochorismatase
OIO47_RS00335	COG0385	Bile acid
OIO47_RS00340	COG0534	Mate efflux family protein
OIO47_RS00345	COG1683	Conserved Protein
OIO47_RS00365	COG0625	glutathione transferase activity
OIO47_RS00375	COG1113	amino acid transport
OIO47_RS00385	COG0523	cobalamin synthesis protein
OIO47_RS00395	COG2188	Transcriptional regulator
OIO47_RS00425	COG0010	Belongs to the arginase family
OIO47_RS00445	COG1280	lysine exporter protein (LysE YggA)
OIO47_RS00470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OIO47_RS00480	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
OIO47_RS00485	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
OIO47_RS00570	COG0534	Mate efflux family protein
OIO47_RS00575	COG0436	Aminotransferase
OIO47_RS00580	COG2733	membrane
OIO47_RS00595	COG2918	glutathione biosynthetic process
OIO47_RS00620	COG3150	esterase
OIO47_RS00630	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
OIO47_RS00640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO47_RS00650	COG2233	PERMEase
OIO47_RS00655	COG2351	hydroxyisourate hydrolase activity
OIO47_RS00690	COG3706	GGDEF domain
OIO47_RS00705	COG1393	Belongs to the ArsC family
OIO47_RS00710	COG0708	Exodeoxyribonuclease III
OIO47_RS00730	COG0189	ligase activity
OIO47_RS00750	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
OIO47_RS00760	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OIO47_RS00775	COG4942	peptidase
OIO47_RS00785	COG0508	dehydrogenase complex catalyzes the overall conversion of
OIO47_RS00795	COG2119	membrane
OIO47_RS00800	COG4774	siderophore transport
OIO47_RS00805	COG0426	domain, Protein
OIO47_RS00805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO47_RS00830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OIO47_RS00855	COG1902	pentaerythritol trinitrate reductase activity
OIO47_RS00860	COG1519	Transferase
OIO47_RS00865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OIO47_RS00870	COG0668	transmembrane transport
OIO47_RS00880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OIO47_RS00885	COG1335	isochorismatase
OIO47_RS00890	COG1522	sequence-specific DNA binding
OIO47_RS00915	COG0784	Response regulator, receiver
OIO47_RS00915	COG2198	Histidine kinase
OIO47_RS00915	COG2205	protein histidine kinase activity
OIO47_RS00920	COG3162	membrane
OIO47_RS00925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OIO47_RS00935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OIO47_RS00955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OIO47_RS00960	COG1309	transcriptional regulator
OIO47_RS00980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OIO47_RS00980	COG0352	thiamine-phosphate diphosphorylase activity
OIO47_RS00980	COG0351	phosphomethylpyrimidine kinase
OIO47_RS00990	COG2814	Major facilitator Superfamily
OIO47_RS01030	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
OIO47_RS01040	COG1113	amino acid transport
OIO47_RS01050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OIO47_RS01055	COG1012	belongs to the aldehyde dehydrogenase family
OIO47_RS01065	COG1335	isochorismatase
OIO47_RS01100	COG2814	Major facilitator Superfamily
OIO47_RS01105	COG0583	DNA-binding transcription factor activity
OIO47_RS01120	COG1309	transcriptional regulator
OIO47_RS01140	COG0667	Aldo Keto reductase
OIO47_RS01175	COG1733	regulation of RNA biosynthetic process
OIO47_RS01180	COG2249	NAD(P)H dehydrogenase (quinone) activity
OIO47_RS01245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
OIO47_RS01260	COG2329	Antibiotic biosynthesis monooxygenase
OIO47_RS01275	COG1132	(ABC) transporter
OIO47_RS01295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
OIO47_RS01325	COG0427	acetyl-CoA hydrolase
OIO47_RS01350	COG0659	secondary active sulfate transmembrane transporter activity
OIO47_RS01355	COG4221	oxidoreductase activity
OIO47_RS01360	COG2873	o-acetylhomoserine
OIO47_RS01365	COG0488	(ABC) transporter
OIO47_RS01430	COG0833	amino acid
OIO47_RS01475	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OIO47_RS01480	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OIO47_RS01495	COG2226	methyltransferase
OIO47_RS01545	COG0070	glutamate synthase
OIO47_RS01545	COG0069	glutamate synthase activity
OIO47_RS01545	COG0067	glutamate synthase
OIO47_RS01550	COG0493	'glutamate synthase
OIO47_RS01560	COG1704	LemA family
OIO47_RS01565	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
OIO47_RS01580	COG3307	-O-antigen
OIO47_RS01600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OIO47_RS01615	COG0194	GDP metabolic process
OIO47_RS01670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OIO47_RS01690	COG5380	lipid catabolic process
OIO47_RS01695	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
OIO47_RS01720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OIO47_RS01725	COG0277	FAD linked oxidase domain protein
OIO47_RS01735	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
OIO47_RS01740	COG2249	NAD(P)H dehydrogenase (quinone) activity
OIO47_RS01755	COG1289	transmembrane transporter activity
OIO47_RS01765	COG0628	permease
OIO47_RS01770	COG1192	Involved in chromosome partitioning
OIO47_RS01800	COG0833	amino acid
OIO47_RS01805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
OIO47_RS01810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OIO47_RS01820	COG1012	belongs to the aldehyde dehydrogenase family
OIO47_RS01860	COG0583	DNA-binding transcription factor activity
OIO47_RS01885	COG0752	glycyl-tRNA synthetase alpha subunit
OIO47_RS01910	COG0517	IMP dehydrogenase activity
OIO47_RS01915	COG1983	PspC domain protein
OIO47_RS01925	COG1960	acyl-CoA dehydrogenase activity
OIO47_RS01940	COG0408	coproporphyrinogen oxidase activity
OIO47_RS01960	COG0513	Belongs to the DEAD box helicase family
OIO47_RS01970	COG1127	ABC transporter
OIO47_RS01975	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OIO47_RS01985	COG2854	intermembrane phospholipid transfer
OIO47_RS01995	COG0598	Magnesium transport protein CorA
OIO47_RS02005	COG0494	nUDIX hydrolase
OIO47_RS02010	COG1040	competence protein
OIO47_RS02015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OIO47_RS02035	COG1946	Acyl-CoA thioesterase
OIO47_RS02040	COG1301	dicarboxylic acid transport
OIO47_RS02055	COG1959	2 iron, 2 sulfur cluster binding
OIO47_RS02060	COG1017	nitric oxide dioxygenase activity
OIO47_RS02060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO47_RS02225	COG1960	acyl-CoA dehydrogenase activity
OIO47_RS02230	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
OIO47_RS02260	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
OIO47_RS02265	COG0339	signal peptide processing
OIO47_RS02270	COG0557	exoribonuclease II activity
OIO47_RS02315	COG0179	Fumarylacetoacetate (FAA) hydrolase
OIO47_RS02320	COG2169	Transcriptional regulator
OIO47_RS02325	COG0697	spore germination
OIO47_RS02330	COG1295	ribonuclease BN
OIO47_RS02365	COG1702	phosphate starvation-inducible protein PhoH
OIO47_RS02375	COG0741	lytic transglycosylase activity
OIO47_RS02375	COG1196	nuclear chromosome segregation
OIO47_RS02375	COG0739	heme binding
OIO47_RS02405	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
OIO47_RS02410	COG1183	phosphatidylcholine synthase activity
OIO47_RS02455	COG1960	acyl-CoA dehydrogenase activity
OIO47_RS02460	COG1309	transcriptional regulator
OIO47_RS02475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OIO47_RS02480	COG1960	acyl-CoA dehydrogenase activity
OIO47_RS02500	COG2969	positive regulation of protein catabolic process
OIO47_RS02510	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OIO47_RS02520	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
OIO47_RS02525	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OIO47_RS02530	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OIO47_RS02550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OIO47_RS02560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OIO47_RS02565	COG1408	metallophosphoesterase
OIO47_RS02575	COG2199	diguanylate cyclase activity
OIO47_RS02635	COG1607	acyl-coa hydrolase
OIO47_RS02665	COG2350	Protein conserved in bacteria
OIO47_RS02675	COG0613	PHP domain protein
OIO47_RS02680	COG3781	membrane
OIO47_RS02690	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OIO47_RS02695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OIO47_RS02705	COG1862	Preprotein translocase
OIO47_RS02735	COG2205	protein histidine kinase activity
OIO47_RS02740	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
OIO47_RS02760	COG0726	polysaccharide deacetylase
OIO47_RS02765	COG0463	Glycosyl transferase, family 2
OIO47_RS02770	COG0438	transferase activity, transferring glycosyl groups
OIO47_RS02835	COG1960	acyl-CoA dehydrogenase activity
OIO47_RS02840	COG1960	acyl-CoA dehydrogenase activity
OIO47_RS02850	COG2205	protein histidine kinase activity
OIO47_RS02855	COG0745	RESPONSE REGULATOR receiver
OIO47_RS02860	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
OIO47_RS02875	COG0584	glycerophosphoryl diester phosphodiesterase
OIO47_RS02880	COG2096	Adenosyltransferase
OIO47_RS02930	COG0285	dihydrofolate synthase activity
OIO47_RS02950	COG0450	alkyl hydroperoxide reductase
OIO47_RS02965	COG0477	Major facilitator Superfamily
OIO47_RS02970	COG1272	protein, Hemolysin III
OIO47_RS03000	COG0183	Belongs to the thiolase family
OIO47_RS03005	COG2207	Transcriptional regulator
OIO47_RS03025	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO47_RS03045	COG0183	Belongs to the thiolase family
OIO47_RS03055	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
OIO47_RS03055	COG2885	chlorophyll binding
OIO47_RS03065	COG1690	Belongs to the RtcB family
OIO47_RS03070	COG0833	amino acid
OIO47_RS03080	COG2233	PERMEase
OIO47_RS03085	COG1217	gtp-binding protein TYPA
OIO47_RS03110	COG2094	Belongs to the DNA glycosylase MPG family
OIO47_RS03115	COG4772	TonB-dependent receptor
OIO47_RS03120	COG1902	pentaerythritol trinitrate reductase activity
OIO47_RS03135	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OIO47_RS03140	COG0354	folic acid binding
OIO47_RS03150	COG3189	MarR family transcriptional regulator
OIO47_RS03155	COG2824	Alkylphosphonate utilization operon protein PhnA
OIO47_RS03160	COG3422	double-strand break repair
OIO47_RS03200	COG0840	transmembrane signaling receptor activity
OIO47_RS03225	COG5510	response to toxic substance
OIO47_RS03235	COG2832	Protein of unknown function (DUF454)
OIO47_RS03240	COG1376	ErfK ybiS ycfS ynhG family protein
OIO47_RS03290	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OIO47_RS03300	COG1289	transmembrane transporter activity
OIO47_RS03305	COG2814	Major facilitator Superfamily
OIO47_RS03325	COG1115	amino acid carrier protein
OIO47_RS03330	COG1752	Esterase of the alpha-beta hydrolase superfamily
OIO47_RS03335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OIO47_RS03340	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
OIO47_RS03365	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OIO47_RS03375	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OIO47_RS03380	COG1077	Cell shape determining protein MreB Mrl
OIO47_RS03385	COG1792	Involved in formation and maintenance of cell shape
OIO47_RS03390	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
OIO47_RS03395	COG0424	maF-like protein
OIO47_RS03400	COG1530	ribonuclease E activity
OIO47_RS03410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO47_RS03420	COG0560	Phosphoserine phosphatase
OIO47_RS03430	COG2249	NAD(P)H dehydrogenase (quinone) activity
OIO47_RS03455	COG2207	Transcriptional regulator
OIO47_RS03500	COG1113	amino acid transport
OIO47_RS03505	COG2828	Protein conserved in bacteria
OIO47_RS03510	COG0142	geranyltranstransferase activity
OIO47_RS03515	COG2315	Protein conserved in bacteria
OIO47_RS03530	COG1752	Esterase of the alpha-beta hydrolase superfamily
OIO47_RS03550	COG2194	sulfuric ester hydrolase activity
OIO47_RS03555	COG0745	RESPONSE REGULATOR receiver
OIO47_RS03560	COG0642	Histidine kinase
OIO47_RS03575	COG0004	ammonium transporteR
OIO47_RS03580	COG0583	DNA-binding transcription factor activity
OIO47_RS03600	COG0525	valine-tRNA ligase activity
OIO47_RS03610	COG1028	Short-chain dehydrogenase reductase Sdr
OIO47_RS03620	COG0393	Putative heavy-metal-binding
OIO47_RS03625	COG0393	Putative heavy-metal-binding
OIO47_RS03630	COG1538	Outer membrane efflux protein
OIO47_RS03640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO47_RS03675	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
OIO47_RS03690	COG1648	precorrin-2 dehydrogenase activity
OIO47_RS03690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OIO47_RS03695	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OIO47_RS03700	COG1733	regulation of RNA biosynthetic process
OIO47_RS03710	COG0531	amino acid
OIO47_RS03725	COG0321	lipoyl(octanoyl) transferase activity
OIO47_RS03730	COG2921	Belongs to the UPF0250 family
OIO47_RS03765	COG2009	succinate dehydrogenase
OIO47_RS03770	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
OIO47_RS03775	COG1053	succinate dehydrogenase
OIO47_RS03780	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OIO47_RS03805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OIO47_RS03825	COG2354	Protein conserved in bacteria
OIO47_RS03830	COG2321	neutral zinc metallopeptidase
OIO47_RS03850	COG2843	Capsule synthesis protein
OIO47_RS03865	COG0589	response to stress
OIO47_RS03885	COG0505	Belongs to the CarA family
OIO47_RS03910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OIO47_RS03915	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OIO47_RS03965	COG0477	Major facilitator Superfamily
OIO47_RS03970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OIO47_RS03985	COG1597	lipid kinase activity
OIO47_RS03990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
OIO47_RS04015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OIO47_RS04020	COG0584	glycerophosphoryl diester phosphodiesterase
OIO47_RS04040	COG0741	lytic transglycosylase activity
OIO47_RS04060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OIO47_RS04075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO47_RS04100	COG3811	Belongs to the UPF0386 family
OIO47_RS04125	COG0778	Nitroreductase
OIO47_RS04140	COG1929	Belongs to the glycerate kinase type-1 family
OIO47_RS04145	COG0243	molybdopterin cofactor binding
OIO47_RS04150	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OIO47_RS04155	COG3339	Conserved Protein
OIO47_RS04165	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
OIO47_RS04180	COG1113	amino acid transport
OIO47_RS04190	COG0019	diaminopimelate decarboxylase activity
OIO47_RS04200	COG2267	carboxylic ester hydrolase activity
OIO47_RS04205	COG1280	lysine exporter protein (LysE YggA)
OIO47_RS04210	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OIO47_RS04240	COG0463	Glycosyl transferase, family 2
OIO47_RS04260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO47_RS04295	COG4591	ABC-type transport system involved in lipoprotein release permease component
OIO47_RS04300	COG1136	(ABC) transporter
OIO47_RS04305	COG0658	competence protein
OIO47_RS04305	COG2333	competence protein COMEC
OIO47_RS04315	COG0616	signal peptide processing
OIO47_RS04315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OIO47_RS04320	COG0596	Alpha beta hydrolase
OIO47_RS04325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OIO47_RS04335	COG0628	permease
OIO47_RS04370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OIO47_RS04390	COG0823	Involved in the tonB-independent uptake of proteins
OIO47_RS04410	COG0824	Thioesterase
OIO47_RS04415	COG1473	amidohydrolase
OIO47_RS04435	COG0047	phosphoribosylformylglycinamidine synthase activity
OIO47_RS04435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OIO47_RS04440	COG2814	Major facilitator Superfamily
OIO47_RS04455	COG1024	Enoyl-CoA hydratase
OIO47_RS04460	COG1051	belongs to the nudix hydrolase family
OIO47_RS04460	COG1056	cytidyltransferase-related domain
OIO47_RS04470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
OIO47_RS04485	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
OIO47_RS04500	COG4625	pathogenesis
OIO47_RS04505	COG0583	DNA-binding transcription factor activity
OIO47_RS04510	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
OIO47_RS04515	COG4208	sulfate ABC transporter
OIO47_RS04520	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
OIO47_RS04530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
OIO47_RS04535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OIO47_RS04540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OIO47_RS04560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OIO47_RS04570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OIO47_RS04580	COG0681	Belongs to the peptidase S26 family
OIO47_RS04595	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
OIO47_RS04605	COG1381	Involved in DNA repair and RecF pathway recombination
OIO47_RS04610	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
OIO47_RS04620	COG4221	oxidoreductase activity
OIO47_RS04650	COG0443	Heat shock 70 kDa protein
OIO47_RS04660	COG0436	Aminotransferase
OIO47_RS04680	COG0556	nucleotide-excision repair
OIO47_RS04735	COG2070	2-Nitropropane dioxygenase
OIO47_RS04750	COG1252	NADH dehydrogenase
OIO47_RS04755	COG1686	Belongs to the peptidase S11 family
OIO47_RS04770	COG1187	pseudouridine synthase activity
OIO47_RS04965	COG4695	Portal protein
OIO47_RS05105	COG0582	viral genome integration into host DNA
OIO47_RS05130	COG0477	Major facilitator Superfamily
OIO47_RS05135	COG0583	DNA-binding transcription factor activity
OIO47_RS05140	COG1823	symporter activity
OIO47_RS05150	COG0612	Peptidase, M16
OIO47_RS05175	COG0352	thiamine-phosphate diphosphorylase activity
OIO47_RS05210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO47_RS05225	COG1309	transcriptional regulator
OIO47_RS05235	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OIO47_RS05240	COG0076	glutamate decarboxylase activity
OIO47_RS05250	COG1522	sequence-specific DNA binding
OIO47_RS05255	COG3961	Belongs to the TPP enzyme family
OIO47_RS05260	COG1113	amino acid transport
OIO47_RS05265	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OIO47_RS05270	COG0573	inorganic phosphate transmembrane transporter activity
OIO47_RS05280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OIO47_RS05285	COG0616	signal peptide processing
OIO47_RS05320	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
OIO47_RS05325	COG1686	Belongs to the peptidase S11 family
OIO47_RS05350	COG0583	DNA-binding transcription factor activity
OIO47_RS05355	COG1067	ATP-dependent peptidase activity
OIO47_RS05380	COG4943	cyclic-guanylate-specific phosphodiesterase activity
OIO47_RS05405	COG1966	Carbon starvation protein
OIO47_RS05410	COG2879	small protein
OIO47_RS05450	COG1335	isochorismatase
OIO47_RS05455	COG0583	DNA-binding transcription factor activity
OIO47_RS05470	COG0596	Alpha beta hydrolase
OIO47_RS05480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OIO47_RS05490	COG2130	NADP-dependent
OIO47_RS05520	COG1741	Belongs to the pirin family
OIO47_RS05530	COG2964	Protein conserved in bacteria
OIO47_RS05545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO47_RS05555	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OIO47_RS05560	COG4605	iron ion homeostasis
OIO47_RS05565	COG4604	ABC transporter, ATP-binding protein
OIO47_RS05570	COG4607	ABC-type enterochelin transport system periplasmic component
OIO47_RS05575	COG4774	siderophore transport
OIO47_RS05585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO47_RS05590	COG1021	2,3-dihydroxybenzoate-AMP ligase
OIO47_RS05595	COG1535	isochorismatase
OIO47_RS05595	COG3433	isochorismatase activity
OIO47_RS05610	COG1132	(ABC) transporter
OIO47_RS05615	COG1132	(ABC) transporter
OIO47_RS05620	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
OIO47_RS05625	COG2977	Belongs to the P-Pant transferase superfamily
OIO47_RS05645	COG3739	integral membrane protein
OIO47_RS05665	COG0302	gtp cyclohydrolase
OIO47_RS05675	COG1529	Aldehyde oxidase and xanthine dehydrogenase
OIO47_RS05705	COG0308	aminopeptidase N
OIO47_RS05710	COG0512	Glutamine amidotransferase of anthranilate synthase
OIO47_RS05725	COG0174	glutamine synthetase
OIO47_RS05735	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
OIO47_RS05770	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OIO47_RS05775	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
OIO47_RS05780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OIO47_RS05800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OIO47_RS05805	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
OIO47_RS05810	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
OIO47_RS05825	COG1960	acyl-CoA dehydrogenase activity
OIO47_RS05830	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OIO47_RS05835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OIO47_RS05845	COG2223	nitrite transmembrane transporter activity
OIO47_RS05865	COG0024	Methionine aminopeptidase
OIO47_RS05870	COG0052	Belongs to the universal ribosomal protein uS2 family
OIO47_RS05885	COG2207	Transcriptional regulator
OIO47_RS05910	COG2951	lytic endotransglycosylase activity
OIO47_RS05915	COG0772	Belongs to the SEDS family
OIO47_RS05930	COG0842	Transport permease protein
OIO47_RS05935	COG1131	(ABC) transporter
OIO47_RS05980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO47_RS05995	COG4215	(ABC) transporter
OIO47_RS06000	COG4160	amino acid transport
OIO47_RS06005	COG4598	ABC transporter
OIO47_RS06015	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OIO47_RS06020	COG0826	peptidase U32
OIO47_RS06025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO47_RS06040	COG1720	tRNA m6t6A37 methyltransferase activity
OIO47_RS06050	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OIO47_RS06065	COG0642	Histidine kinase
OIO47_RS06075	COG0494	nUDIX hydrolase
OIO47_RS06085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OIO47_RS06090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OIO47_RS06095	COG3139	Protein of unknown function (DUF1315)
OIO47_RS06105	COG1301	dicarboxylic acid transport
OIO47_RS06110	COG1960	acyl-CoA dehydrogenase activity
OIO47_RS06115	COG2819	hydrolase of the alpha beta superfamily
OIO47_RS06125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
OIO47_RS06135	COG2195	Cleaves the N-terminal amino acid of tripeptides
OIO47_RS06155	COG1690	Belongs to the RtcB family
OIO47_RS06160	COG1234	tRNA 3'-trailer cleavage
OIO47_RS06165	COG4650	regulator
OIO47_RS06195	COG2363	Small membrane protein
OIO47_RS06220	COG0513	Belongs to the DEAD box helicase family
OIO47_RS06230	COG0778	Nitroreductase
OIO47_RS06260	COG1286	toxin biosynthetic process
OIO47_RS06285	COG4783	chaperone-mediated protein folding
OIO47_RS06290	COG1610	YqeY-like protein
OIO47_RS06320	COG0515	serine threonine protein kinase
OIO47_RS06320	COG2815	serine threonine protein kinase
OIO47_RS06390	COG3111	PFAM Bacterial OB fold (BOF) protein
OIO47_RS06415	COG3243	poly(R)-hydroxyalkanoic acid synthase
OIO47_RS06420	COG0786	glutamate:sodium symporter activity
OIO47_RS06430	COG2186	Transcriptional regulator
OIO47_RS06440	COG0477	Major facilitator Superfamily
OIO47_RS06470	COG2995	paraquat-inducible protein a
OIO47_RS06475	COG3008	intermembrane lipid transfer
OIO47_RS06475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OIO47_RS06485	COG1794	racemase activity, acting on amino acids and derivatives
OIO47_RS06515	COG1301	dicarboxylic acid transport
OIO47_RS06525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OIO47_RS06530	COG2011	ABC-type metal ion transport system permease component
OIO47_RS06535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OIO47_RS06540	COG1464	Belongs to the NlpA lipoprotein family
OIO47_RS06545	COG0151	Belongs to the GarS family
OIO47_RS06550	COG0138	bifunctional purine biosynthesis protein purh
OIO47_RS06555	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
OIO47_RS06585	COG2308	Evidence 4 Homologs of previously reported genes of
OIO47_RS06595	COG1305	Transglutaminase-like
OIO47_RS06605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OIO47_RS06610	COG0305	Participates in initiation and elongation during chromosome replication
OIO47_RS06635	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
OIO47_RS06645	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OIO47_RS06650	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OIO47_RS06675	COG0726	polysaccharide deacetylase
OIO47_RS06675	COG1649	PFAM Uncharacterised BCR, COG1649
OIO47_RS06680	COG1215	transferase activity, transferring glycosyl groups
OIO47_RS06685	COG3658	cytochrome
OIO47_RS06695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OIO47_RS06710	COG0583	DNA-binding transcription factor activity
OIO47_RS06730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO47_RS06735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO47_RS06750	COG1960	acyl-CoA dehydrogenase activity
OIO47_RS06755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OIO47_RS06760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO47_RS06775	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
OIO47_RS06785	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
OIO47_RS06790	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
OIO47_RS06805	COG0745	RESPONSE REGULATOR receiver
OIO47_RS06810	COG0174	glutamine synthetase
OIO47_RS06830	COG0729	surface antigen
OIO47_RS06855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OIO47_RS06860	COG2814	Major facilitator Superfamily
OIO47_RS06875	COG0583	DNA-binding transcription factor activity
OIO47_RS06890	COG1187	pseudouridine synthase activity
OIO47_RS06910	COG0802	atpase or kinase
OIO47_RS06915	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OIO47_RS06925	COG1923	regulation of RNA biosynthetic process
OIO47_RS06930	COG0697	spore germination
OIO47_RS06955	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OIO47_RS06960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OIO47_RS06960	COG0519	Catalyzes the synthesis of GMP from XMP
OIO47_RS06965	COG4302	ethanolamine ammonia-lyase activity
OIO47_RS06970	COG4303	Ethanolamine ammonia lyase large subunit
OIO47_RS06975	COG0531	amino acid
OIO47_RS06995	COG1454	alcohol dehydrogenase
OIO47_RS07000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OIO47_RS07010	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
OIO47_RS07030	COG0308	aminopeptidase N
OIO47_RS07050	COG1605	Chorismate mutase
OIO47_RS07070	COG1309	transcriptional regulator
OIO47_RS07080	COG0668	transmembrane transport
OIO47_RS07110	COG4773	Receptor
OIO47_RS07130	COG0488	(ABC) transporter
OIO47_RS07135	COG0589	response to stress
OIO47_RS07160	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
OIO47_RS07170	COG3135	benzoate transporter
OIO47_RS07175	COG1522	sequence-specific DNA binding
OIO47_RS07185	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OIO47_RS07190	COG0583	DNA-binding transcription factor activity
OIO47_RS07200	COG0183	Belongs to the thiolase family
OIO47_RS07210	COG2030	dehydratase
OIO47_RS07215	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OIO47_RS07230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OIO47_RS07240	COG0824	Thioesterase
OIO47_RS07245	COG1454	alcohol dehydrogenase
OIO47_RS07255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OIO47_RS07275	COG0069	glutamate synthase activity
OIO47_RS07295	COG2814	Major facilitator Superfamily
OIO47_RS07310	COG0511	ligase activity, forming carbon-carbon bonds
OIO47_RS07330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO47_RS07330	COG1116	anion transmembrane transporter activity
OIO47_RS07335	COG0745	RESPONSE REGULATOR receiver
OIO47_RS07345	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO47_RS07345	COG2146	nitrite reductase [NAD(P)H] activity
OIO47_RS07350	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO47_RS07355	COG0243	molybdopterin cofactor binding
OIO47_RS07365	COG0243	molybdopterin cofactor binding
OIO47_RS07385	COG0315	cyclic pyranopterin monophosphate synthase activity
OIO47_RS07385	COG0521	Mo-molybdopterin cofactor biosynthetic process
OIO47_RS07400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO47_RS07405	COG0697	spore germination
OIO47_RS07425	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
OIO47_RS07430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OIO47_RS07485	COG2204	response regulator
OIO47_RS07490	COG3852	Histidine kinase
OIO47_RS07510	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OIO47_RS07515	COG0575	Belongs to the CDS family
OIO47_RS07530	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OIO47_RS07550	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OIO47_RS07565	COG2137	regulation of response to DNA damage stimulus
OIO47_RS07575	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
OIO47_RS07580	COG1011	Hydrolase
OIO47_RS07605	COG1522	sequence-specific DNA binding
OIO47_RS07615	COG1113	amino acid transport
OIO47_RS07635	COG0659	secondary active sulfate transmembrane transporter activity
OIO47_RS07640	COG2135	peptidase activity
OIO47_RS07655	COG5001	Diguanylate cyclase
OIO47_RS07655	COG3300	MHYT domain
OIO47_RS07675	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OIO47_RS07675	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OIO47_RS07675	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
OIO47_RS07680	COG1105	Belongs to the carbohydrate kinase PfkB family
OIO47_RS07685	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OIO47_RS07685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OIO47_RS07715	COG0024	Methionine aminopeptidase
OIO47_RS07720	COG0583	DNA-binding transcription factor activity
OIO47_RS07730	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
OIO47_RS07735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OIO47_RS07740	COG0517	IMP dehydrogenase activity
OIO47_RS07740	COG0516	GMP reductase activity
OIO47_RS07765	COG0552	protein localization to endoplasmic reticulum
OIO47_RS07775	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
OIO47_RS07785	COG4890	Cyd operon protein YbgT
OIO47_RS07790	COG1294	oxidase, subunit
OIO47_RS07805	COG1585	Membrane protein implicated in regulation of membrane protease activity
OIO47_RS07815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OIO47_RS07820	COG4774	siderophore transport
OIO47_RS07835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OIO47_RS07840	COG0569	domain protein
OIO47_RS07845	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OIO47_RS07875	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
OIO47_RS07880	COG0542	response to heat
OIO47_RS07890	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OIO47_RS07905	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO47_RS07905	COG1902	pentaerythritol trinitrate reductase activity
OIO47_RS07950	COG2323	membrane
OIO47_RS07955	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
OIO47_RS07965	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
OIO47_RS07970	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OIO47_RS07975	COG0183	Belongs to the thiolase family
OIO47_RS07980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OIO47_RS07985	COG0596	Alpha beta hydrolase
OIO47_RS07990	COG2271	Major facilitator Superfamily
OIO47_RS07995	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OIO47_RS08000	COG3485	protocatechuate 3,4-dioxygenase
OIO47_RS08005	COG3485	protocatechuate 3,4-dioxygenase
OIO47_RS08010	COG0710	3-dehydroquinate dehydratase activity
OIO47_RS08015	COG3420	alginic acid biosynthetic process
OIO47_RS08020	COG3659	wide pore channel activity
OIO47_RS08025	COG4993	Dehydrogenase
OIO47_RS08035	COG2391	methyltransferase activity
OIO47_RS08050	COG1414	Transcriptional regulator
OIO47_RS08055	COG0583	DNA-binding transcription factor activity
OIO47_RS08060	COG1960	acyl-CoA dehydrogenase activity
OIO47_RS08085	COG2814	Major facilitator Superfamily
OIO47_RS08095	COG0154	amidase activity
OIO47_RS08115	COG4638	Rieske (2fe-2S)
OIO47_RS08125	COG1028	Short-chain dehydrogenase reductase Sdr
OIO47_RS08135	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO47_RS08145	COG3733	amine oxidase
OIO47_RS08155	COG1012	belongs to the aldehyde dehydrogenase family
OIO47_RS08165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OIO47_RS08170	COG0183	Belongs to the thiolase family
OIO47_RS08175	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OIO47_RS08180	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
OIO47_RS08190	COG4829	muconolactone delta-isomerase
OIO47_RS08195	COG4948	Mandelate Racemase Muconate Lactonizing
OIO47_RS08200	COG0583	DNA-binding transcription factor activity
OIO47_RS08210	COG2186	Transcriptional regulator
OIO47_RS08230	COG1012	belongs to the aldehyde dehydrogenase family
OIO47_RS08235	COG3231	kanamycin kinase activity
OIO47_RS08250	COG1960	acyl-CoA dehydrogenase activity
OIO47_RS08255	COG1028	Short-chain dehydrogenase reductase Sdr
OIO47_RS08260	COG3829	transcription factor binding
OIO47_RS08270	COG3162	membrane
OIO47_RS08285	COG1012	belongs to the aldehyde dehydrogenase family
OIO47_RS08300	COG0753	catalase activity
OIO47_RS08325	COG1846	Transcriptional regulator
OIO47_RS08330	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO47_RS08330	COG1902	pentaerythritol trinitrate reductase activity
OIO47_RS08365	COG1309	transcriptional regulator
OIO47_RS08375	COG1335	isochorismatase
OIO47_RS08380	COG0583	DNA-binding transcription factor activity
OIO47_RS08390	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OIO47_RS08390	COG0475	glutathione-regulated potassium exporter activity
OIO47_RS08400	COG1473	amidohydrolase
OIO47_RS08455	COG2188	Transcriptional regulator
OIO47_RS08470	COG0583	DNA-binding transcription factor activity
OIO47_RS08505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OIO47_RS08525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OIO47_RS08545	COG1012	belongs to the aldehyde dehydrogenase family
OIO47_RS08560	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OIO47_RS08565	COG2814	Major facilitator Superfamily
OIO47_RS08575	COG0179	Fumarylacetoacetate (FAA) hydrolase
OIO47_RS08585	COG1012	belongs to the aldehyde dehydrogenase family
OIO47_RS08590	COG3384	dioxygenase
OIO47_RS08600	COG3971	2-oxopent-4-enoate hydratase activity
OIO47_RS08615	COG0477	Major facilitator Superfamily
OIO47_RS08620	COG1960	acyl-CoA dehydrogenase activity
OIO47_RS08625	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO47_RS08630	COG1846	Transcriptional regulator
OIO47_RS08635	COG1012	belongs to the aldehyde dehydrogenase family
OIO47_RS08640	COG0129	dihydroxy-acid dehydratase activity
OIO47_RS08650	COG0583	DNA-binding transcription factor activity
OIO47_RS08655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OIO47_RS08665	COG2084	Dehydrogenase
OIO47_RS08670	COG2207	Transcriptional regulator
OIO47_RS08685	COG1064	alcohol dehydrogenase
OIO47_RS08695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OIO47_RS08700	COG1120	ATPase activity
OIO47_RS08720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OIO47_RS08770	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
OIO47_RS08795	COG2814	Major facilitator Superfamily
OIO47_RS08800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OIO47_RS08800	COG3320	Male sterility
OIO47_RS08830	COG1028	Short-chain dehydrogenase reductase Sdr
OIO47_RS08840	COG2207	Transcriptional regulator
OIO47_RS08850	COG2205	protein histidine kinase activity
OIO47_RS08855	COG0745	RESPONSE REGULATOR receiver
OIO47_RS08860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO47_RS08865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OIO47_RS08890	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
OIO47_RS08900	COG0753	catalase activity
OIO47_RS08920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OIO47_RS08980	COG1535	isochorismatase
OIO47_RS08980	COG3433	isochorismatase activity
OIO47_RS08985	COG1028	Short-chain dehydrogenase reductase Sdr
OIO47_RS08990	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
OIO47_RS08995	COG4149	molybdate abc transporter
OIO47_RS09000	COG0725	ABC transporter, periplasmic molybdate-binding protein
OIO47_RS09010	COG4638	Rieske (2fe-2S)
OIO47_RS09015	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
OIO47_RS09020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO47_RS09020	COG0543	2 iron, 2 sulfur cluster binding
OIO47_RS09035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO47_RS09045	COG1028	Short-chain dehydrogenase reductase Sdr
OIO47_RS09060	COG2207	Transcriptional regulator
OIO47_RS09065	COG1028	Short-chain dehydrogenase reductase Sdr
OIO47_RS09070	COG2610	gluconate transmembrane transporter activity
OIO47_RS09080	COG0583	DNA-binding transcription factor activity
OIO47_RS09095	COG2031	fatty acid transporter
OIO47_RS09100	COG0183	Belongs to the thiolase family
OIO47_RS09105	COG0583	DNA-binding transcription factor activity
OIO47_RS09110	COG0583	DNA-binding transcription factor activity
OIO47_RS09125	COG1027	Aspartate ammonia-lyase
OIO47_RS09135	COG0477	Major facilitator Superfamily
OIO47_RS09155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO47_RS09160	COG4521	taurine ABC transporter
OIO47_RS09175	COG2188	Transcriptional regulator
OIO47_RS09185	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
OIO47_RS09190	COG1733	regulation of RNA biosynthetic process
OIO47_RS09195	COG2207	Transcriptional regulator
OIO47_RS09195	COG3708	Transcriptional regulator
OIO47_RS09210	COG0730	response to heat
OIO47_RS09225	COG3453	Protein conserved in bacteria
OIO47_RS09225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OIO47_RS09235	COG3781	membrane
OIO47_RS09240	COG1063	alcohol dehydrogenase
OIO47_RS09250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OIO47_RS09255	COG0508	dehydrogenase complex catalyzes the overall conversion of
OIO47_RS09260	COG0022	dehydrogenase e1 component
OIO47_RS09265	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
OIO47_RS09270	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OIO47_RS09285	COG3706	GGDEF domain
OIO47_RS09300	COG0133	tryptophan synthase activity
OIO47_RS09310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OIO47_RS09345	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OIO47_RS09370	COG2226	methyltransferase
OIO47_RS09425	COG0842	Transport permease protein
OIO47_RS09430	COG0842	Transport permease protein
OIO47_RS09435	COG1131	(ABC) transporter
OIO47_RS09450	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OIO47_RS09475	COG0730	response to heat
OIO47_RS09480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OIO47_RS09495	COG0406	alpha-ribazole phosphatase activity
OIO47_RS09500	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
OIO47_RS09515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OIO47_RS09545	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OIO47_RS09555	COG4264	IucA IucC family
OIO47_RS09560	COG4264	IucA IucC family
OIO47_RS09565	COG2814	Major facilitator Superfamily
OIO47_RS09580	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OIO47_RS09595	COG1960	acyl-CoA dehydrogenase activity
OIO47_RS09600	COG1960	acyl-CoA dehydrogenase activity
OIO47_RS09605	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OIO47_RS09610	COG2207	Transcriptional regulator
OIO47_RS09615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OIO47_RS09620	COG0776	regulation of translation
OIO47_RS09645	COG0822	iron-sulfur transferase activity
OIO47_RS09650	COG0316	Belongs to the HesB IscA family
OIO47_RS09680	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OIO47_RS09700	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OIO47_RS09705	COG0702	epimerase
OIO47_RS09740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OIO47_RS09750	COG0339	signal peptide processing
OIO47_RS09760	COG4166	transmembrane transport
OIO47_RS09795	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OIO47_RS09800	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
OIO47_RS09830	COG0776	regulation of translation
OIO47_RS09895	COG0084	hydrolase, TatD family'
OIO47_RS09915	COG1663	tetraacyldisaccharide 4'-kinase activity
OIO47_RS09920	COG1132	(ABC) transporter
OIO47_RS09930	COG0811	peptide transport
OIO47_RS09935	COG1475	DNA binding
OIO47_RS09940	COG1192	Involved in chromosome partitioning
OIO47_RS09950	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
OIO47_RS09965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OIO47_RS09970	COG0191	fructose-bisphosphate aldolase activity
OIO47_RS09990	COG0424	maF-like protein
OIO47_RS09995	COG2850	peptidyl-arginine hydroxylation
OIO47_RS10005	COG0640	Transcriptional regulator
OIO47_RS10015	COG3619	membrane
OIO47_RS10020	COG3122	Protein conserved in bacteria
OIO47_RS10025	COG1132	(ABC) transporter
OIO47_RS10045	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
OIO47_RS10050	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OIO47_RS10060	COG0506	proline dehydrogenase activity
OIO47_RS10060	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
OIO47_RS10060	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
OIO47_RS10065	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
OIO47_RS10080	COG3698	Phosphodiester glycosidase
OIO47_RS10090	COG2353	YceI-like domain
OIO47_RS10100	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
OIO47_RS10145	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
OIO47_RS10145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OIO47_RS10170	COG3539	Fimbrial protein
OIO47_RS10175	COG3121	Chaperone
OIO47_RS10200	COG0697	spore germination
OIO47_RS10210	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
OIO47_RS10220	COG0583	DNA-binding transcription factor activity
OIO47_RS10240	COG1309	transcriptional regulator
OIO47_RS10255	COG1522	sequence-specific DNA binding
OIO47_RS10265	COG1126	abc transporter atp-binding protein
OIO47_RS10270	COG0765	amino acid transport
OIO47_RS10275	COG0765	amino acid transport
OIO47_RS10305	COG1464	Belongs to the NlpA lipoprotein family
OIO47_RS10315	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OIO47_RS10320	COG2011	ABC-type metal ion transport system permease component
OIO47_RS10325	COG0012	GTP binding
OIO47_RS10350	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
OIO47_RS10390	COG0386	Belongs to the glutathione peroxidase family
OIO47_RS10400	COG0436	Aminotransferase
OIO47_RS10405	COG1301	dicarboxylic acid transport
OIO47_RS10440	COG3634	alkyl hydroperoxide reductase activity
OIO47_RS10455	COG0583	DNA-binding transcription factor activity
OIO47_RS10460	COG0798	PFAM Bile acid sodium symporter
OIO47_RS10465	COG0640	Transcriptional regulator
OIO47_RS10480	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
OIO47_RS10490	COG0583	DNA-binding transcription factor activity
OIO47_RS10500	COG1953	Uracil, thiamine, allantoin
OIO47_RS10510	COG2175	clavaminate synthase activity
OIO47_RS10515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO47_RS10535	COG4521	taurine ABC transporter
OIO47_RS10545	COG0477	Major facilitator Superfamily
OIO47_RS10565	COG1271	oxidase subunit
OIO47_RS10570	COG1294	oxidase, subunit
OIO47_RS10580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO47_RS10600	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
OIO47_RS10620	COG3052	prosthetic group binding
OIO47_RS10625	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
OIO47_RS10635	COG0583	DNA-binding transcription factor activity
OIO47_RS10645	COG2814	Major facilitator Superfamily
OIO47_RS10665	COG1346	cytolysis
OIO47_RS10675	COG0583	DNA-binding transcription factor activity
OIO47_RS10680	COG0625	glutathione transferase activity
OIO47_RS10685	COG0625	glutathione transferase activity
OIO47_RS10690	COG0583	DNA-binding transcription factor activity
OIO47_RS10695	COG1028	Short-chain dehydrogenase reductase Sdr
OIO47_RS10705	COG1045	serine acetyltransferase
OIO47_RS10710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OIO47_RS10715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OIO47_RS10725	COG1280	lysine exporter protein (LysE YggA)
OIO47_RS10740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OIO47_RS10745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OIO47_RS10750	COG1126	abc transporter atp-binding protein
OIO47_RS10755	COG0765	amino acid transport
OIO47_RS10760	COG0765	amino acid transport
OIO47_RS10780	COG0784	Response regulator, receiver
OIO47_RS10780	COG2205	protein histidine kinase activity
OIO47_RS10800	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OIO47_RS10820	COG1028	Short-chain dehydrogenase reductase Sdr
OIO47_RS10870	COG0583	DNA-binding transcription factor activity
OIO47_RS10890	COG0318	PFAM AMP-dependent synthetase and ligase
OIO47_RS10895	COG1309	transcriptional regulator
OIO47_RS10900	COG1960	acyl-CoA dehydrogenase activity
OIO47_RS10905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OIO47_RS10910	COG1024	Enoyl-CoA hydratase
OIO47_RS10915	COG4770	biotin carboxylase activity
OIO47_RS10925	COG0583	DNA-binding transcription factor activity
OIO47_RS10945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OIO47_RS10965	COG3842	ATPase activity
OIO47_RS10970	COG1840	ABC-type Fe3 transport system, periplasmic component
OIO47_RS10985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO47_RS10990	COG1414	Transcriptional regulator
OIO47_RS11000	COG0583	DNA-binding transcription factor activity
OIO47_RS11005	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OIO47_RS11010	COG1012	belongs to the aldehyde dehydrogenase family
OIO47_RS11020	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
OIO47_RS11030	COG1012	belongs to the aldehyde dehydrogenase family
OIO47_RS11035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OIO47_RS11040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO47_RS11045	COG2267	carboxylic ester hydrolase activity
OIO47_RS11065	COG3038	cytochrome b561
OIO47_RS11070	COG0753	catalase activity
OIO47_RS11075	COG2271	Major facilitator Superfamily
OIO47_RS11080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OIO47_RS11085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OIO47_RS11230	COG1116	anion transmembrane transporter activity
OIO47_RS11235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OIO47_RS11245	COG0864	Transcriptional regulator
OIO47_RS11255	COG1733	regulation of RNA biosynthetic process
OIO47_RS11260	COG2249	NAD(P)H dehydrogenase (quinone) activity
OIO47_RS11265	COG0439	Biotin carboxylase
OIO47_RS11280	COG1063	alcohol dehydrogenase
OIO47_RS11290	COG1309	transcriptional regulator
OIO47_RS11330	COG0038	chloride channel
OIO47_RS11335	COG4770	biotin carboxylase activity
OIO47_RS11355	COG1914	H( )-stimulated, divalent metal cation uptake system
OIO47_RS11415	COG1250	3-hydroxyacyl-CoA dehydrogenase
OIO47_RS11440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO47_RS11445	COG1116	anion transmembrane transporter activity
OIO47_RS11450	COG2515	1-aminocyclopropane-1-carboxylate deaminase
OIO47_RS11480	COG0598	Magnesium transport protein CorA
OIO47_RS11490	COG1560	Kdo2-lipid A biosynthetic process
OIO47_RS11500	COG5006	permease, DMT superfamily
OIO47_RS11505	COG1522	sequence-specific DNA binding
OIO47_RS11520	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
OIO47_RS11530	COG4122	O-methyltransferase activity
OIO47_RS11565	COG1137	ATPase activity
OIO47_RS11570	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
OIO47_RS11580	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
OIO47_RS11585	COG0517	IMP dehydrogenase activity
OIO47_RS11585	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
OIO47_RS11625	COG2814	Major facilitator Superfamily
OIO47_RS11660	COG1278	Cold shock
OIO47_RS11665	COG1280	lysine exporter protein (LysE YggA)
OIO47_RS11695	COG1570	exodeoxyribonuclease VII activity
OIO47_RS11745	COG0583	DNA-binding transcription factor activity
OIO47_RS11755	COG4638	Rieske (2fe-2S)
OIO47_RS11765	COG0543	2 iron, 2 sulfur cluster binding
OIO47_RS11765	COG0633	Ferredoxin
OIO47_RS11770	COG1028	Short-chain dehydrogenase reductase Sdr
OIO47_RS11775	COG3135	benzoate transporter
OIO47_RS11780	COG2814	Major facilitator Superfamily
OIO47_RS11795	COG1643	Atp-dependent helicase
OIO47_RS11800	COG0450	alkyl hydroperoxide reductase
OIO47_RS11810	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
OIO47_RS11820	COG3634	alkyl hydroperoxide reductase activity
OIO47_RS11840	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OIO47_RS12000	COG0625	glutathione transferase activity
OIO47_RS12010	COG2885	chlorophyll binding
OIO47_RS12045	COG0542	response to heat
OIO47_RS12060	COG1765	OsmC-like protein
OIO47_RS12075	COG0667	Aldo Keto reductase
OIO47_RS12090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OIO47_RS12105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OIO47_RS12115	COG0527	aspartate kinase activity
OIO47_RS12125	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
OIO47_RS12135	COG3038	cytochrome b561
OIO47_RS12140	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
OIO47_RS12145	COG2252	PERMEase
OIO47_RS12155	COG2072	flavoprotein involved in K transport
OIO47_RS12170	COG1741	Belongs to the pirin family
OIO47_RS12175	COG1309	transcriptional regulator
OIO47_RS12185	COG0300	oxidoreductase activity
OIO47_RS12190	COG2072	flavoprotein involved in K transport
OIO47_RS12195	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
OIO47_RS12240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO47_RS12260	COG2814	Major facilitator Superfamily
OIO47_RS12265	COG1024	Enoyl-CoA hydratase
OIO47_RS12270	COG1012	belongs to the aldehyde dehydrogenase family
OIO47_RS12280	COG1960	acyl-CoA dehydrogenase activity
OIO47_RS12305	COG2186	Transcriptional regulator
OIO47_RS12310	COG1012	belongs to the aldehyde dehydrogenase family
OIO47_RS12320	COG4948	Mandelate Racemase Muconate Lactonizing
OIO47_RS12325	COG2271	Major facilitator Superfamily
OIO47_RS12330	COG2721	sulfolactate sulfo-lyase activity
OIO47_RS12335	COG0697	spore germination
OIO47_RS12380	COG1113	amino acid transport
OIO47_RS12400	COG1012	belongs to the aldehyde dehydrogenase family
OIO47_RS12420	COG0531	amino acid
OIO47_RS12430	COG1113	amino acid transport
OIO47_RS12470	COG3209	COG3209 Rhs family protein
OIO47_RS12490	COG4269	membrane
OIO47_RS12505	COG1902	pentaerythritol trinitrate reductase activity
OIO47_RS12505	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO47_RS12515	COG3706	GGDEF domain
OIO47_RS12515	COG2203	Gaf domain
OIO47_RS12515	COG4251	negative regulation of phosphorylation
OIO47_RS12515	COG5001	Diguanylate cyclase
OIO47_RS12525	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OIO47_RS12550	COG4172	Belongs to the ABC transporter superfamily
OIO47_RS12555	COG4239	(ABC) transporter, permease
OIO47_RS12560	COG4174	ABC transporter (Permease)
OIO47_RS12570	COG1388	LysM domain
OIO47_RS12570	COG0741	lytic transglycosylase activity
OIO47_RS12570	COG1388	LysM domain
OIO47_RS12570	COG0741	lytic transglycosylase activity
OIO47_RS12575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OIO47_RS12615	COG0583	DNA-binding transcription factor activity
OIO47_RS12620	COG1279	arginine transmembrane transporter activity
OIO47_RS12640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO47_RS12645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO47_RS12650	COG0006	proline dipeptidase activity
OIO47_RS12685	COG2194	sulfuric ester hydrolase activity
OIO47_RS12850	COG5410	chromosome segregation
OIO47_RS13030	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OIO47_RS13050	COG3384	dioxygenase
OIO47_RS13060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
OIO47_RS13065	COG2878	Part of a membrane complex involved in electron transport
OIO47_RS13070	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OIO47_RS13095	COG0768	penicillin binding
OIO47_RS13100	COG0742	ribosomal rna small subunit methyltransferase
OIO47_RS13115	COG0830	nickel cation binding
OIO47_RS13125	COG0804	urea catabolic process
OIO47_RS13165	COG1253	flavin adenine dinucleotide binding
OIO47_RS13170	COG2851	Citrate transporter
OIO47_RS13220	COG1773	rubredoxin
OIO47_RS13225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO47_RS13235	COG0583	DNA-binding transcription factor activity
OIO47_RS13265	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
OIO47_RS13270	COG4181	ATPase activity
OIO47_RS13315	COG1262	PFAM Formylglycine-generating sulfatase enzyme
OIO47_RS13340	COG0306	phosphate transporter
OIO47_RS13350	COG3958	Transketolase
OIO47_RS13355	COG3959	Transketolase, thiamine diphosphate binding domain
OIO47_RS13360	COG2271	Major facilitator Superfamily
OIO47_RS13365	COG1028	Short-chain dehydrogenase reductase Sdr
OIO47_RS13370	COG0583	DNA-binding transcription factor activity
OIO47_RS13390	COG2207	Transcriptional regulator
OIO47_RS13395	COG2066	Belongs to the glutaminase family
OIO47_RS13400	COG0242	peptide deformylase activity
OIO47_RS13405	COG0477	Major facilitator Superfamily
OIO47_RS13415	COG0028	Belongs to the TPP enzyme family
OIO47_RS13430	COG1028	Short-chain dehydrogenase reductase Sdr
OIO47_RS13435	COG2267	carboxylic ester hydrolase activity
OIO47_RS13445	COG2271	Major facilitator Superfamily
OIO47_RS13450	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO47_RS13460	COG1028	Short-chain dehydrogenase reductase Sdr
OIO47_RS13480	COG1414	Transcriptional regulator
OIO47_RS13495	COG1024	Enoyl-CoA hydratase
OIO47_RS13505	COG1215	transferase activity, transferring glycosyl groups
OIO47_RS13510	COG1649	PFAM Uncharacterised BCR, COG1649
OIO47_RS13510	COG0726	polysaccharide deacetylase
OIO47_RS13520	COG4681	YaeQ
OIO47_RS13530	COG0523	cobalamin synthesis protein
OIO47_RS13540	COG1607	acyl-coa hydrolase
OIO47_RS13550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OIO47_RS13555	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OIO47_RS13560	COG1309	transcriptional regulator
OIO47_RS13585	COG2040	homocysteine
OIO47_RS13590	COG0531	amino acid
OIO47_RS13645	COG1595	DNA-templated transcription, initiation
OIO47_RS13655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OIO47_RS13660	COG0477	Major facilitator Superfamily
OIO47_RS13670	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
OIO47_RS13730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OIO47_RS13815	COG0592	DNA-directed DNA polymerase activity
OIO47_RS13855	COG2026	Addiction module toxin, RelE StbE family
OIO47_RS14075	COG1484	DNA-dependent DNA replication
OIO47_RS14160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OIO47_RS14240	COG0405	Gamma-glutamyltransferase
OIO47_RS14245	COG2814	Major facilitator Superfamily
OIO47_RS14255	COG2050	protein possibly involved in aromatic compounds catabolism
OIO47_RS14270	COG1090	epimerase
OIO47_RS14290	COG0420	3'-5' exonuclease activity
OIO47_RS14315	COG0735	belongs to the Fur family
OIO47_RS14320	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OIO47_RS14340	COG0121	glutamine amidotransferase
OIO47_RS14355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OIO47_RS14365	COG0210	DNA helicase
OIO47_RS14370	COG2885	chlorophyll binding
OIO47_RS14375	COG0204	Acyl-transferase
OIO47_RS14390	COG2894	cell division
OIO47_RS14405	COG1280	lysine exporter protein (LysE YggA)
OIO47_RS14410	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OIO47_RS14410	COG1674	ftsk spoiiie
OIO47_RS14415	COG0492	ferredoxin-NADP+ reductase activity
OIO47_RS14420	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
OIO47_RS14430	COG0456	acetyltransferase
OIO47_RS14475	COG1981	membrane
OIO47_RS14490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
OIO47_RS14490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OIO47_RS14510	COG1012	belongs to the aldehyde dehydrogenase family
OIO47_RS14520	COG0657	acetylesterase activity
OIO47_RS14530	COG0473	3-isopropylmalate dehydrogenase activity
OIO47_RS14535	COG0583	DNA-binding transcription factor activity
OIO47_RS14565	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OIO47_RS14590	COG0564	pseudouridine synthase activity
OIO47_RS14600	COG0358	DNA primase activity
OIO47_RS14615	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
OIO47_RS14645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OIO47_RS14675	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OIO47_RS14685	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OIO47_RS14685	COG0351	phosphomethylpyrimidine kinase
OIO47_RS14685	COG0352	thiamine-phosphate diphosphorylase activity
OIO47_RS14690	COG1652	LysM domain
OIO47_RS14715	COG1399	metal-binding, possibly nucleic acid-binding protein
OIO47_RS14720	COG3101	peptidyl-lysine hydroxylation
OIO47_RS14725	COG0009	L-threonylcarbamoyladenylate synthase
OIO47_RS14730	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
OIO47_RS14735	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
OIO47_RS14750	COG4106	trans-aconitate 2-methyltransferase activity
OIO47_RS14765	COG0596	Alpha beta hydrolase
OIO47_RS14765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OIO47_RS14765	COG2226	methyltransferase
OIO47_RS14770	COG1877	trehalose-phosphatase activity
OIO47_RS14775	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
OIO47_RS14780	COG2223	nitrite transmembrane transporter activity
OIO47_RS14800	COG1196	nuclear chromosome segregation
OIO47_RS14810	COG0730	response to heat
OIO47_RS14825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OIO47_RS14835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OIO47_RS14885	COG0489	protein tyrosine kinase activity
OIO47_RS14895	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OIO47_RS14895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OIO47_RS14925	COG2515	1-aminocyclopropane-1-carboxylate deaminase
OIO47_RS14930	COG2081	HI0933 family
OIO47_RS14940	COG0668	transmembrane transport
OIO47_RS14960	COG0583	DNA-binding transcription factor activity
OIO47_RS14985	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OIO47_RS14990	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OIO47_RS15020	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
OIO47_RS15060	COG0745	RESPONSE REGULATOR receiver
OIO47_RS15080	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OIO47_RS15085	COG0697	spore germination
OIO47_RS15120	COG0477	Major facilitator Superfamily
OIO47_RS15130	COG1028	Short-chain dehydrogenase reductase Sdr
OIO47_RS15150	COG0384	phenazine biosynthesis protein PhzF
OIO47_RS15195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO47_RS15210	COG0583	DNA-binding transcription factor activity
OIO47_RS15220	COG0583	DNA-binding transcription factor activity
OIO47_RS15235	COG0583	DNA-binding transcription factor activity
OIO47_RS15240	COG1053	succinate dehydrogenase
OIO47_RS15250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OIO47_RS15255	COG2814	Major facilitator Superfamily
OIO47_RS15260	COG1960	acyl-CoA dehydrogenase activity
OIO47_RS15265	COG0583	DNA-binding transcription factor activity
OIO47_RS15270	COG1063	alcohol dehydrogenase
OIO47_RS15300	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
OIO47_RS15305	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
OIO47_RS15310	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OIO47_RS15330	COG2132	Multicopper oxidase
OIO47_RS15340	COG0561	phosphatase activity
OIO47_RS15345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OIO47_RS15355	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
OIO47_RS15370	COG1214	PFAM Peptidase M22, glycoprotease
OIO47_RS15440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OIO47_RS15445	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OIO47_RS15450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OIO47_RS15510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OIO47_RS15520	COG1846	Transcriptional regulator
OIO47_RS15525	COG1764	response to oxidative stress
OIO47_RS15565	COG0037	tRNA processing
OIO47_RS15575	COG0248	Ppx GppA phosphatase
OIO47_RS15605	COG0072	phenylalanine-tRNA ligase activity
OIO47_RS15650	COG1238	metal cluster binding
OIO47_RS15655	COG0625	glutathione transferase activity
OIO47_RS15670	COG0318	PFAM AMP-dependent synthetase and ligase
OIO47_RS15675	COG3028	Belongs to the UPF0307 family
OIO47_RS15680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OIO47_RS15700	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OIO47_RS15705	COG0617	tRNA 3'-terminal CCA addition
OIO47_RS15710	COG1555	photosystem II stabilization
OIO47_RS15715	COG3956	TIGRFAM MazG family protein
OIO47_RS15725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OIO47_RS15745	COG2205	protein histidine kinase activity
OIO47_RS15745	COG0784	Response regulator, receiver
OIO47_RS15745	COG5002	protein histidine kinase activity
OIO47_RS15750	COG1024	Enoyl-CoA hydratase
OIO47_RS15755	COG2084	Dehydrogenase
OIO47_RS15760	COG3622	Belongs to the hyi family
OIO47_RS15795	COG0697	spore germination
OIO47_RS15805	COG2814	Major facilitator Superfamily
OIO47_RS15815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OIO47_RS15885	COG4774	siderophore transport
OIO47_RS15900	COG1271	oxidase subunit
OIO47_RS15905	COG1294	oxidase, subunit
OIO47_RS15975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OIO47_RS15985	COG0583	DNA-binding transcription factor activity
OIO47_RS15995	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
OIO47_RS16005	COG0084	hydrolase, TatD family'
OIO47_RS16020	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OIO47_RS16050	COG0440	acetolactate synthase activity
OIO47_RS16055	COG0028	Belongs to the TPP enzyme family
OIO47_RS16080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO47_RS16085	COG0577	efflux transmembrane transporter activity
OIO47_RS16085	COG1136	(ABC) transporter
OIO47_RS16090	COG1538	Outer membrane efflux protein
OIO47_RS16105	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
OIO47_RS16110	COG1162	GTPase activity
OIO47_RS16120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OIO47_RS16160	COG1426	Protein conserved in bacteria
OIO47_RS16195	COG0793	Belongs to the peptidase S41A family
OIO47_RS16210	COG2267	carboxylic ester hydrolase activity
OIO47_RS16220	COG1012	belongs to the aldehyde dehydrogenase family
OIO47_RS16225	COG3265	gluconokinase activity
OIO47_RS16235	COG0800	Aldolase
OIO47_RS16245	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OIO47_RS16250	COG0857	belongs to the CobB CobQ family
OIO47_RS16250	COG0280	phosphate acetyltransferase
OIO47_RS16255	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
OIO47_RS16255	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
OIO47_RS16275	COG0740	serine-type endopeptidase activity
OIO47_RS16285	COG4774	siderophore transport
OIO47_RS16295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OIO47_RS16305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OIO47_RS16305	COG2813	Specifically methylates the guanine in position
OIO47_RS16405	COG0788	formyltetrahydrofolate deformylase activity
OIO47_RS16430	COG4651	solute:proton antiporter activity
OIO47_RS16430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OIO47_RS16450	COG0724	RNA recognition motif
OIO47_RS16455	COG0210	DNA helicase
OIO47_RS16480	COG1733	regulation of RNA biosynthetic process
OIO47_RS16490	COG2900	Belongs to the SlyX family
OIO47_RS16495	COG0488	(ABC) transporter
OIO47_RS16500	COG1280	lysine exporter protein (LysE YggA)
OIO47_RS16505	COG1560	Kdo2-lipid A biosynthetic process
OIO47_RS16515	COG1301	dicarboxylic acid transport
OIO47_RS16570	COG0473	3-isopropylmalate dehydrogenase activity
OIO47_RS16625	COG0583	DNA-binding transcription factor activity
OIO47_RS16635	COG0625	glutathione transferase activity
OIO47_RS16640	COG2378	regulation of single-species biofilm formation
OIO47_RS16645	COG0546	phosphoglycolate phosphatase activity
OIO47_RS16655	COG1530	ribonuclease E activity
OIO47_RS16660	COG0318	PFAM AMP-dependent synthetase and ligase
OIO47_RS16675	COG0583	DNA-binding transcription factor activity
OIO47_RS16680	COG1028	Short-chain dehydrogenase reductase Sdr
OIO47_RS16685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OIO47_RS16695	COG0534	Mate efflux family protein
OIO47_RS16710	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OIO47_RS16735	COG0493	'glutamate synthase
OIO47_RS16735	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
OIO47_RS16745	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
OIO47_RS16750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OIO47_RS16765	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
OIO47_RS16775	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
OIO47_RS16775	COG0644	oxidoreductase
OIO47_RS16785	COG0425	Belongs to the sulfur carrier protein TusA family
OIO47_RS16790	COG4535	Mg2 and Co2 transporter CorC
OIO47_RS16800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OIO47_RS16820	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OIO47_RS16825	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OIO47_RS16825	COG0475	glutathione-regulated potassium exporter activity
OIO47_RS16840	COG0484	heat shock protein binding
OIO47_RS16845	COG0789	Transcriptional regulator
OIO47_RS16850	COG0598	Magnesium transport protein CorA
OIO47_RS16865	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OIO47_RS16870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OIO47_RS16875	COG1074	ATP-dependent DNA helicase activity
OIO47_RS16880	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
OIO47_RS16900	COG2226	methyltransferase
OIO47_RS16920	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OIO47_RS16935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OIO47_RS16935	COG2111	Na H antiporter
OIO47_RS16940	COG1006	Multisubunit Na H antiporter MnhC subunit
OIO47_RS16945	COG0651	ATP synthesis coupled electron transport
OIO47_RS16950	COG1863	multisubunit Na H antiporter MnhE subunit
OIO47_RS16955	COG2212	antiporter activity
OIO47_RS16960	COG1320	monovalent cation:proton antiporter activity
OIO47_RS16975	COG0195	Participates in both transcription termination and antitermination
OIO47_RS17025	COG0237	dephospho-CoA kinase activity
OIO47_RS17035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OIO47_RS17050	COG0497	DNA recombination
OIO47_RS17060	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
OIO47_RS17090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OIO47_RS17090	COG2169	Transcriptional regulator
OIO47_RS17095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OIO47_RS17155	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OIO47_RS17170	COG0326	Molecular chaperone. Has ATPase activity
OIO47_RS17185	COG2056	Na+-H+ antiporter family
OIO47_RS17285	COG0546	phosphoglycolate phosphatase activity
OIO47_RS17290	COG1716	ATPase activity
OIO47_RS17335	COG0181	hydroxymethylbilane synthase activity
OIO47_RS17345	COG3275	phosphorelay sensor kinase activity
OIO47_RS17365	COG1538	Outer membrane efflux protein
OIO47_RS17370	COG0697	spore germination
OIO47_RS17415	COG1061	Type III restriction enzyme res subunit
OIO47_RS17420	COG1002	Type II restriction enzyme, methylase subunits
OIO47_RS17430	COG0659	secondary active sulfate transmembrane transporter activity
OIO47_RS17435	COG0589	response to stress
OIO47_RS17480	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
OIO47_RS17485	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
OIO47_RS17490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OIO47_RS17495	COG0772	Belongs to the SEDS family
OIO47_RS17520	COG4974	Belongs to the 'phage' integrase family
OIO47_RS17525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OIO47_RS17535	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
OIO47_RS17545	COG2197	response regulator
OIO47_RS17560	COG0793	Belongs to the peptidase S41A family
OIO47_RS17565	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
OIO47_RS17570	COG0795	lipopolysaccharide-transporting ATPase activity
OIO47_RS17610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OIO47_RS17610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OIO47_RS17620	COG0004	ammonium transporteR
OIO47_RS17625	COG0347	Belongs to the P(II) protein family
OIO47_RS17660	COG1061	Type III restriction enzyme res subunit
OIO47_RS17665	COG1002	Type II restriction enzyme, methylase subunits
OIO47_RS17680	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
OIO47_RS17695	COG0318	PFAM AMP-dependent synthetase and ligase
OIO47_RS17705	COG0477	Major facilitator Superfamily
OIO47_RS17710	COG2860	membrane
OIO47_RS17720	COG1253	flavin adenine dinucleotide binding
OIO47_RS17730	COG0477	Major facilitator Superfamily
OIO47_RS17735	COG3757	hydrolase, family 25
OIO47_RS17740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OIO47_RS17780	COG0655	NAD(P)H dehydrogenase (quinone) activity
OIO47_RS17790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OIO47_RS17860	COG0758	DNA mediated transformation
OIO47_RS17870	COG0697	spore germination
OIO47_RS17875	COG1309	transcriptional regulator
OIO47_RS17890	COG0386	Belongs to the glutathione peroxidase family
OIO47_RS17955	COG1121	(ABC) transporter
OIO47_RS17960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OIO47_RS17965	COG1280	lysine exporter protein (LysE YggA)
OIO47_RS17970	COG2837	iron assimilation
OIO47_RS17980	COG0281	malic enzyme
OIO47_RS18025	COG0519	Catalyzes the synthesis of GMP from XMP
OIO47_RS18025	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OIO47_RS18030	COG4399	Belongs to the UPF0754 family
OIO47_RS18035	COG2259	Doxx family
OIO47_RS18040	COG0586	Pfam SNARE associated Golgi protein
OIO47_RS18055	COG1192	Involved in chromosome partitioning
OIO47_RS18065	COG0271	Belongs to the BolA IbaG family
OIO47_RS18085	COG2267	carboxylic ester hydrolase activity
OIO47_RS18105	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
OIO47_RS18105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OIO47_RS18105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OIO47_RS18105	COG3321	synthase
OIO47_RS18110	COG1960	acyl-CoA dehydrogenase activity
OIO47_RS18120	COG2197	response regulator
OIO47_RS18130	COG3916	Acyl-homoserine-lactone synthase
OIO47_RS18135	COG0477	Major facilitator Superfamily
OIO47_RS18140	COG1024	Enoyl-CoA hydratase
OIO47_RS18145	COG1024	Enoyl-CoA hydratase
OIO47_RS18150	COG1960	acyl-CoA dehydrogenase activity
OIO47_RS18155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OIO47_RS18175	COG1113	amino acid transport
OIO47_RS18180	COG1113	amino acid transport
OIO47_RS18185	COG0251	oxidation-reduction process
OIO47_RS18225	COG0564	pseudouridine synthase activity
OIO47_RS18255	COG1051	belongs to the nudix hydrolase family
OIO47_RS18280	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
OIO47_RS18295	COG1802	Transcriptional regulator
OIO47_RS18305	COG1448	Aminotransferase
OIO47_RS18310	COG0277	FAD linked oxidase domain protein
OIO47_RS18320	COG2186	Transcriptional regulator
OIO47_RS18330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OIO47_RS18335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OIO47_RS18350	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OIO47_RS18360	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
OIO47_RS18370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
OIO47_RS18375	COG0438	transferase activity, transferring glycosyl groups
OIO47_RS18385	COG0438	transferase activity, transferring glycosyl groups
OIO47_RS18405	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
OIO47_RS18435	COG0728	peptidoglycan biosynthetic process
OIO47_RS18440	COG3023	N-Acetylmuramoyl-L-alanine amidase
OIO47_RS18475	COG1017	nitric oxide dioxygenase activity
OIO47_RS18475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO47_RS18500	COG0546	phosphoglycolate phosphatase activity
OIO47_RS18505	COG1028	Short-chain dehydrogenase reductase Sdr
OIO47_RS18525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO47_RS18530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO47_RS18535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OIO47_RS18540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO47_RS18545	COG1116	anion transmembrane transporter activity
OIO47_RS18550	COG1309	transcriptional regulator
OIO47_RS18555	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
OIO47_RS18565	COG0196	riboflavin kinase activity
OIO47_RS18570	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OIO47_RS18580	COG1047	Peptidyl-prolyl cis-trans
OIO47_RS18620	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OIO47_RS18625	COG0657	acetylesterase activity
OIO47_RS18645	COG0583	DNA-binding transcription factor activity
OIO47_RS18675	COG2951	lytic endotransglycosylase activity
OIO47_RS18680	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
OIO47_RS18695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OIO47_RS18705	COG0671	phosphoesterase, PA-phosphatase related
OIO47_RS18710	COG0861	Integral membrane protein TerC family
OIO47_RS18720	COG0754	glutathionylspermidine amidase activity
OIO47_RS18730	COG0402	S-adenosylhomocysteine deaminase activity
OIO47_RS18745	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OIO47_RS18750	COG1230	cation diffusion facilitator family transporter
OIO47_RS18765	COG0706	membrane insertase activity
OIO47_RS18880	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
OIO47_RS18885	COG4683	PFAM Phage derived protein Gp49-like (DUF891)