locus-tag	class	description
H2Q98_RS00125	COG3657	addiction module killer protein
H2Q98_RS00130	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2Q98_RS00150	COG0488	(ABC) transporter
H2Q98_RS00155	COG3173	Aminoglycoside phosphotransferase
H2Q98_RS00170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2Q98_RS00180	COG1570	exodeoxyribonuclease VII activity
H2Q98_RS00200	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS00225	COG3621	Patatin-like phospholipase
H2Q98_RS00250	COG0582	viral genome integration into host DNA
H2Q98_RS00275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H2Q98_RS00310	COG2184	nucleotidyltransferase activity
H2Q98_RS00480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H2Q98_RS00515	COG1660	Displays ATPase and GTPase activities
H2Q98_RS00540	COG3077	Addiction module antitoxin, RelB DinJ family
H2Q98_RS00555	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H2Q98_RS00585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H2Q98_RS00595	COG1846	Transcriptional regulator
H2Q98_RS00600	COG1764	response to oxidative stress
H2Q98_RS00640	COG0037	tRNA processing
H2Q98_RS00650	COG0248	Ppx GppA phosphatase
H2Q98_RS00680	COG0072	phenylalanine-tRNA ligase activity
H2Q98_RS00710	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H2Q98_RS00725	COG1238	metal cluster binding
H2Q98_RS00730	COG0625	glutathione transferase activity
H2Q98_RS00745	COG0318	PFAM AMP-dependent synthetase and ligase
H2Q98_RS00750	COG3028	Belongs to the UPF0307 family
H2Q98_RS00755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2Q98_RS00775	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H2Q98_RS00780	COG0617	tRNA 3'-terminal CCA addition
H2Q98_RS00785	COG1555	photosystem II stabilization
H2Q98_RS00790	COG3956	TIGRFAM MazG family protein
H2Q98_RS00795	COG4221	oxidoreductase activity
H2Q98_RS00800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H2Q98_RS00815	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H2Q98_RS00820	COG0784	Response regulator, receiver
H2Q98_RS00820	COG5002	protein histidine kinase activity
H2Q98_RS00820	COG2205	protein histidine kinase activity
H2Q98_RS00825	COG1024	Enoyl-CoA hydratase
H2Q98_RS00830	COG2084	Dehydrogenase
H2Q98_RS00835	COG3622	Belongs to the hyi family
H2Q98_RS00865	COG0697	spore germination
H2Q98_RS00875	COG2814	Major facilitator Superfamily
H2Q98_RS00910	COG0640	Transcriptional regulator
H2Q98_RS00945	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2Q98_RS00970	COG2132	Multicopper oxidase
H2Q98_RS00985	COG2205	protein histidine kinase activity
H2Q98_RS01070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H2Q98_RS01085	COG0583	DNA-binding transcription factor activity
H2Q98_RS01095	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H2Q98_RS01105	COG0084	hydrolase, TatD family'
H2Q98_RS01120	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H2Q98_RS01140	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H2Q98_RS01145	COG0440	acetolactate synthase activity
H2Q98_RS01150	COG0028	Belongs to the TPP enzyme family
H2Q98_RS01170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2Q98_RS01175	COG1136	(ABC) transporter
H2Q98_RS01175	COG0577	efflux transmembrane transporter activity
H2Q98_RS01205	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H2Q98_RS01210	COG1162	GTPase activity
H2Q98_RS01220	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H2Q98_RS01240	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H2Q98_RS01260	COG1426	Protein conserved in bacteria
H2Q98_RS01295	COG0793	Belongs to the peptidase S41A family
H2Q98_RS01310	COG2267	carboxylic ester hydrolase activity
H2Q98_RS01320	COG1012	belongs to the aldehyde dehydrogenase family
H2Q98_RS01325	COG3265	gluconokinase activity
H2Q98_RS01335	COG0800	Aldolase
H2Q98_RS01350	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H2Q98_RS01355	COG0857	belongs to the CobB CobQ family
H2Q98_RS01355	COG0280	phosphate acetyltransferase
H2Q98_RS01360	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H2Q98_RS01360	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H2Q98_RS01380	COG0740	serine-type endopeptidase activity
H2Q98_RS01390	COG4774	siderophore transport
H2Q98_RS01400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H2Q98_RS01410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2Q98_RS01410	COG2813	Specifically methylates the guanine in position
H2Q98_RS01510	COG0788	formyltetrahydrofolate deformylase activity
H2Q98_RS01535	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H2Q98_RS01535	COG4651	solute:proton antiporter activity
H2Q98_RS01555	COG0724	RNA recognition motif
H2Q98_RS01560	COG0210	DNA helicase
H2Q98_RS01585	COG1733	regulation of RNA biosynthetic process
H2Q98_RS01595	COG2900	Belongs to the SlyX family
H2Q98_RS01600	COG0488	(ABC) transporter
H2Q98_RS01610	COG1560	Kdo2-lipid A biosynthetic process
H2Q98_RS01620	COG1301	dicarboxylic acid transport
H2Q98_RS01675	COG0473	3-isopropylmalate dehydrogenase activity
H2Q98_RS01700	COG0583	DNA-binding transcription factor activity
H2Q98_RS01740	COG0583	DNA-binding transcription factor activity
H2Q98_RS01750	COG0625	glutathione transferase activity
H2Q98_RS01755	COG2378	regulation of single-species biofilm formation
H2Q98_RS01760	COG0546	phosphoglycolate phosphatase activity
H2Q98_RS01770	COG1530	ribonuclease E activity
H2Q98_RS01775	COG0318	PFAM AMP-dependent synthetase and ligase
H2Q98_RS01790	COG0583	DNA-binding transcription factor activity
H2Q98_RS01795	COG1028	Short-chain dehydrogenase reductase Sdr
H2Q98_RS01800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H2Q98_RS01810	COG0534	Mate efflux family protein
H2Q98_RS01825	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H2Q98_RS01850	COG0493	'glutamate synthase
H2Q98_RS01860	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H2Q98_RS01865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2Q98_RS01880	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H2Q98_RS01890	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H2Q98_RS01890	COG0644	oxidoreductase
H2Q98_RS01905	COG4535	Mg2 and Co2 transporter CorC
H2Q98_RS01915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2Q98_RS01935	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H2Q98_RS01945	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H2Q98_RS01955	COG0484	heat shock protein binding
H2Q98_RS01960	COG0789	Transcriptional regulator
H2Q98_RS01965	COG0598	Magnesium transport protein CorA
H2Q98_RS01970	COG1185	polyribonucleotide nucleotidyltransferase activity
H2Q98_RS01980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H2Q98_RS01985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2Q98_RS01990	COG1074	ATP-dependent DNA helicase activity
H2Q98_RS01995	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H2Q98_RS02015	COG2226	methyltransferase
H2Q98_RS02030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2Q98_RS02040	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H2Q98_RS02055	COG2111	Na H antiporter
H2Q98_RS02055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H2Q98_RS02060	COG1006	Multisubunit Na H antiporter MnhC subunit
H2Q98_RS02065	COG0651	ATP synthesis coupled electron transport
H2Q98_RS02070	COG1863	multisubunit Na H antiporter MnhE subunit
H2Q98_RS02075	COG2212	antiporter activity
H2Q98_RS02080	COG1320	monovalent cation:proton antiporter activity
H2Q98_RS02085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H2Q98_RS02095	COG0195	Participates in both transcription termination and antitermination
H2Q98_RS02145	COG0237	dephospho-CoA kinase activity
H2Q98_RS02155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H2Q98_RS02170	COG0497	DNA recombination
H2Q98_RS02180	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H2Q98_RS02215	COG2169	Transcriptional regulator
H2Q98_RS02215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H2Q98_RS02220	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H2Q98_RS02285	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H2Q98_RS02300	COG0326	Molecular chaperone. Has ATPase activity
H2Q98_RS02315	COG2056	Na+-H+ antiporter family
H2Q98_RS02385	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H2Q98_RS02415	COG0546	phosphoglycolate phosphatase activity
H2Q98_RS02420	COG1716	ATPase activity
H2Q98_RS02465	COG0181	hydroxymethylbilane synthase activity
H2Q98_RS02475	COG3275	phosphorelay sensor kinase activity
H2Q98_RS02495	COG1538	Outer membrane efflux protein
H2Q98_RS02505	COG0697	spore germination
H2Q98_RS02525	COG0494	nUDIX hydrolase
H2Q98_RS02530	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H2Q98_RS02535	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H2Q98_RS02540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H2Q98_RS02545	COG0772	Belongs to the SEDS family
H2Q98_RS02570	COG4974	Belongs to the 'phage' integrase family
H2Q98_RS02575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H2Q98_RS02585	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H2Q98_RS02595	COG2197	response regulator
H2Q98_RS02610	COG0793	Belongs to the peptidase S41A family
H2Q98_RS02615	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H2Q98_RS02620	COG0795	lipopolysaccharide-transporting ATPase activity
H2Q98_RS02660	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2Q98_RS02660	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2Q98_RS02670	COG0004	ammonium transporteR
H2Q98_RS02675	COG0347	Belongs to the P(II) protein family
H2Q98_RS02685	COG0606	chelatase, subunit chli
H2Q98_RS02690	COG0431	NADPH-dependent FMN reductase
H2Q98_RS02695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2Q98_RS02700	COG0235	Class ii aldolase
H2Q98_RS02705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2Q98_RS02725	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H2Q98_RS02740	COG0318	PFAM AMP-dependent synthetase and ligase
H2Q98_RS02750	COG0477	Major facilitator Superfamily
H2Q98_RS02755	COG2860	membrane
H2Q98_RS02765	COG1253	flavin adenine dinucleotide binding
H2Q98_RS02775	COG2814	Major facilitator Superfamily
H2Q98_RS02785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2Q98_RS02825	COG0655	NAD(P)H dehydrogenase (quinone) activity
H2Q98_RS02840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H2Q98_RS02870	COG1309	transcriptional regulator
H2Q98_RS02905	COG0758	DNA mediated transformation
H2Q98_RS02915	COG0697	spore germination
H2Q98_RS02920	COG1309	transcriptional regulator
H2Q98_RS02935	COG0386	Belongs to the glutathione peroxidase family
H2Q98_RS02950	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H2Q98_RS02960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H2Q98_RS03000	COG1121	(ABC) transporter
H2Q98_RS03005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H2Q98_RS03010	COG1280	lysine exporter protein (LysE YggA)
H2Q98_RS03015	COG2837	iron assimilation
H2Q98_RS03020	COG0281	malic enzyme
H2Q98_RS03060	COG0519	Catalyzes the synthesis of GMP from XMP
H2Q98_RS03060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H2Q98_RS03065	COG4399	Belongs to the UPF0754 family
H2Q98_RS03070	COG2259	Doxx family
H2Q98_RS03075	COG0586	Pfam SNARE associated Golgi protein
H2Q98_RS03090	COG1192	Involved in chromosome partitioning
H2Q98_RS03100	COG0271	Belongs to the BolA IbaG family
H2Q98_RS03140	COG0300	oxidoreductase activity
H2Q98_RS03140	COG0318	PFAM AMP-dependent synthetase and ligase
H2Q98_RS03140	COG3321	synthase
H2Q98_RS03140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2Q98_RS03140	COG1028	Short-chain dehydrogenase reductase Sdr
H2Q98_RS03145	COG1960	acyl-CoA dehydrogenase activity
H2Q98_RS03150	COG0318	PFAM AMP-dependent synthetase and ligase
H2Q98_RS03155	COG2197	response regulator
H2Q98_RS03160	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS03170	COG3916	Acyl-homoserine-lactone synthase
H2Q98_RS03175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2Q98_RS03185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H2Q98_RS03190	COG1113	amino acid transport
H2Q98_RS03195	COG0697	spore germination
H2Q98_RS03200	COG0477	Major facilitator Superfamily
H2Q98_RS03205	COG1024	Enoyl-CoA hydratase
H2Q98_RS03210	COG1024	Enoyl-CoA hydratase
H2Q98_RS03215	COG1960	acyl-CoA dehydrogenase activity
H2Q98_RS03220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H2Q98_RS03240	COG1113	amino acid transport
H2Q98_RS03245	COG1113	amino acid transport
H2Q98_RS03250	COG0251	oxidation-reduction process
H2Q98_RS03290	COG0564	pseudouridine synthase activity
H2Q98_RS03310	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H2Q98_RS03325	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS03335	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H2Q98_RS03350	COG1802	Transcriptional regulator
H2Q98_RS03360	COG1448	Aminotransferase
H2Q98_RS03365	COG0277	FAD linked oxidase domain protein
H2Q98_RS03375	COG2186	Transcriptional regulator
H2Q98_RS03385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H2Q98_RS03400	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H2Q98_RS03405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H2Q98_RS03445	COG1091	dTDP-4-dehydrorhamnose reductase activity
H2Q98_RS03460	COG2244	polysaccharide biosynthetic process
H2Q98_RS03475	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H2Q98_RS03505	COG0728	peptidoglycan biosynthetic process
H2Q98_RS03510	COG3023	N-Acetylmuramoyl-L-alanine amidase
H2Q98_RS03565	COG0546	phosphoglycolate phosphatase activity
H2Q98_RS03570	COG1028	Short-chain dehydrogenase reductase Sdr
H2Q98_RS03585	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H2Q98_RS03585	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H2Q98_RS03590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2Q98_RS03595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2Q98_RS03600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2Q98_RS03605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2Q98_RS03610	COG1116	anion transmembrane transporter activity
H2Q98_RS03615	COG1309	transcriptional regulator
H2Q98_RS03620	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H2Q98_RS03630	COG0196	riboflavin kinase activity
H2Q98_RS03635	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H2Q98_RS03645	COG1047	Peptidyl-prolyl cis-trans
H2Q98_RS03685	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H2Q98_RS03690	COG0657	acetylesterase activity
H2Q98_RS03740	COG2951	lytic endotransglycosylase activity
H2Q98_RS03745	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H2Q98_RS03760	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H2Q98_RS03770	COG0671	phosphoesterase, PA-phosphatase related
H2Q98_RS03775	COG0861	Integral membrane protein TerC family
H2Q98_RS03785	COG0754	glutathionylspermidine amidase activity
H2Q98_RS03795	COG0402	S-adenosylhomocysteine deaminase activity
H2Q98_RS03810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H2Q98_RS03815	COG1230	cation diffusion facilitator family transporter
H2Q98_RS03830	COG0706	membrane insertase activity
H2Q98_RS03855	COG0592	DNA-directed DNA polymerase activity
H2Q98_RS03865	COG0187	DNA topoisomerase II activity
H2Q98_RS03880	COG0488	(ABC) transporter
H2Q98_RS03905	COG0596	Alpha beta hydrolase
H2Q98_RS03910	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H2Q98_RS03915	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H2Q98_RS03945	COG0625	glutathione transferase activity
H2Q98_RS03955	COG0733	neurotransmitter:sodium symporter activity
H2Q98_RS03995	COG2233	PERMEase
H2Q98_RS04010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2Q98_RS04045	COG2814	Major facilitator Superfamily
H2Q98_RS04050	COG0656	L-ascorbic acid biosynthetic process
H2Q98_RS04055	COG0583	DNA-binding transcription factor activity
H2Q98_RS04070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2Q98_RS04075	COG1064	alcohol dehydrogenase
H2Q98_RS04080	COG2818	Glycosylase
H2Q98_RS04095	COG1194	a g-specific adenine glycosylase
H2Q98_RS04110	COG5487	UPF0391 membrane protein
H2Q98_RS04115	COG2983	Belongs to the UPF0260 family
H2Q98_RS04120	COG2133	pyrroloquinoline quinone binding
H2Q98_RS04125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H2Q98_RS04130	COG2116	formate transmembrane transporter activity
H2Q98_RS04150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2Q98_RS04155	COG1335	isochorismatase
H2Q98_RS04160	COG0385	Bile acid
H2Q98_RS04165	COG0534	Mate efflux family protein
H2Q98_RS04170	COG1683	Conserved Protein
H2Q98_RS04185	COG0346	lactoylglutathione lyase activity
H2Q98_RS04190	COG0625	glutathione transferase activity
H2Q98_RS04200	COG1113	amino acid transport
H2Q98_RS04210	COG0523	cobalamin synthesis protein
H2Q98_RS04220	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS04230	COG2188	Transcriptional regulator
H2Q98_RS04260	COG0010	Belongs to the arginase family
H2Q98_RS04290	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS04300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H2Q98_RS04355	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H2Q98_RS04365	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H2Q98_RS04370	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H2Q98_RS04445	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS04475	COG0534	Mate efflux family protein
H2Q98_RS04480	COG0436	Aminotransferase
H2Q98_RS04485	COG2733	membrane
H2Q98_RS04500	COG2918	glutathione biosynthetic process
H2Q98_RS04520	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS04530	COG3150	esterase
H2Q98_RS04540	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H2Q98_RS04550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2Q98_RS04560	COG2233	PERMEase
H2Q98_RS04565	COG2351	hydroxyisourate hydrolase activity
H2Q98_RS04600	COG3706	GGDEF domain
H2Q98_RS04615	COG1393	Belongs to the ArsC family
H2Q98_RS04620	COG0708	Exodeoxyribonuclease III
H2Q98_RS04650	COG0189	ligase activity
H2Q98_RS04670	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H2Q98_RS04680	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H2Q98_RS04695	COG4942	peptidase
H2Q98_RS04705	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2Q98_RS04715	COG2119	membrane
H2Q98_RS04720	COG4774	siderophore transport
H2Q98_RS04725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2Q98_RS04725	COG0426	domain, Protein
H2Q98_RS04745	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H2Q98_RS04765	COG1902	pentaerythritol trinitrate reductase activity
H2Q98_RS04770	COG1519	Transferase
H2Q98_RS04775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H2Q98_RS04780	COG0668	transmembrane transport
H2Q98_RS04790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H2Q98_RS04795	COG1335	isochorismatase
H2Q98_RS04800	COG1522	sequence-specific DNA binding
H2Q98_RS04825	COG0784	Response regulator, receiver
H2Q98_RS04825	COG2198	Histidine kinase
H2Q98_RS04825	COG2205	protein histidine kinase activity
H2Q98_RS04830	COG3162	membrane
H2Q98_RS04835	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H2Q98_RS04845	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H2Q98_RS04870	COG1309	transcriptional regulator
H2Q98_RS04890	COG0300	oxidoreductase activity
H2Q98_RS04895	COG0789	Transcriptional regulator
H2Q98_RS04900	COG0351	phosphomethylpyrimidine kinase
H2Q98_RS04900	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H2Q98_RS04900	COG0352	thiamine-phosphate diphosphorylase activity
H2Q98_RS04910	COG2814	Major facilitator Superfamily
H2Q98_RS04925	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H2Q98_RS04935	COG1113	amino acid transport
H2Q98_RS04945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H2Q98_RS04950	COG1012	belongs to the aldehyde dehydrogenase family
H2Q98_RS04960	COG1335	isochorismatase
H2Q98_RS04990	COG2814	Major facilitator Superfamily
H2Q98_RS04995	COG0583	DNA-binding transcription factor activity
H2Q98_RS05015	COG0667	Aldo Keto reductase
H2Q98_RS05040	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS05070	COG1733	regulation of RNA biosynthetic process
H2Q98_RS05080	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2Q98_RS05090	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H2Q98_RS05095	COG2207	Transcriptional regulator
H2Q98_RS05155	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H2Q98_RS05170	COG0697	spore germination
H2Q98_RS05195	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H2Q98_RS05225	COG0427	acetyl-CoA hydrolase
H2Q98_RS05250	COG0659	secondary active sulfate transmembrane transporter activity
H2Q98_RS05255	COG4221	oxidoreductase activity
H2Q98_RS05260	COG2873	o-acetylhomoserine
H2Q98_RS05265	COG0488	(ABC) transporter
H2Q98_RS05345	COG0833	amino acid
H2Q98_RS05390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H2Q98_RS05395	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H2Q98_RS05410	COG2226	methyltransferase
H2Q98_RS05460	COG0067	glutamate synthase
H2Q98_RS05460	COG0069	glutamate synthase activity
H2Q98_RS05460	COG0070	glutamate synthase
H2Q98_RS05465	COG0493	'glutamate synthase
H2Q98_RS05475	COG1704	LemA family
H2Q98_RS05480	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H2Q98_RS05490	COG4969	Belongs to the N-Me-Phe pilin family
H2Q98_RS05500	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS05510	COG3328	transposase activity
H2Q98_RS05520	COG3307	-O-antigen
H2Q98_RS05545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H2Q98_RS05560	COG0194	GDP metabolic process
H2Q98_RS05610	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H2Q98_RS05620	COG0335	large ribosomal subunit rRNA binding
H2Q98_RS05630	COG5380	lipid catabolic process
H2Q98_RS05635	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H2Q98_RS05650	COG5006	permease, DMT superfamily
H2Q98_RS05655	COG5006	permease, DMT superfamily
H2Q98_RS05660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H2Q98_RS05665	COG0277	FAD linked oxidase domain protein
H2Q98_RS05675	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H2Q98_RS05680	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2Q98_RS05695	COG1289	transmembrane transporter activity
H2Q98_RS05705	COG0628	permease
H2Q98_RS05710	COG1192	Involved in chromosome partitioning
H2Q98_RS05740	COG0833	amino acid
H2Q98_RS05745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H2Q98_RS05750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H2Q98_RS05760	COG1012	belongs to the aldehyde dehydrogenase family
H2Q98_RS05795	COG3328	transposase activity
H2Q98_RS05805	COG0583	DNA-binding transcription factor activity
H2Q98_RS05820	COG5002	protein histidine kinase activity
H2Q98_RS05845	COG0752	glycyl-tRNA synthetase alpha subunit
H2Q98_RS05870	COG0517	IMP dehydrogenase activity
H2Q98_RS05870	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H2Q98_RS05870	COG0617	tRNA 3'-terminal CCA addition
H2Q98_RS05875	COG1983	PspC domain protein
H2Q98_RS05885	COG1960	acyl-CoA dehydrogenase activity
H2Q98_RS05900	COG0408	coproporphyrinogen oxidase activity
H2Q98_RS05920	COG0513	Belongs to the DEAD box helicase family
H2Q98_RS05930	COG1127	ABC transporter
H2Q98_RS05935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H2Q98_RS05945	COG2854	intermembrane phospholipid transfer
H2Q98_RS05955	COG0598	Magnesium transport protein CorA
H2Q98_RS05965	COG0494	nUDIX hydrolase
H2Q98_RS05970	COG1040	competence protein
H2Q98_RS05975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H2Q98_RS05990	COG2937	Belongs to the GPAT DAPAT family
H2Q98_RS05995	COG1946	Acyl-CoA thioesterase
H2Q98_RS06000	COG1301	dicarboxylic acid transport
H2Q98_RS06015	COG1959	2 iron, 2 sulfur cluster binding
H2Q98_RS06020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2Q98_RS06020	COG1017	nitric oxide dioxygenase activity
H2Q98_RS06030	COG0433	COG0433 Predicted ATPase
H2Q98_RS06035	COG0626	cystathionine gamma-synthase activity
H2Q98_RS06050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H2Q98_RS06055	COG0088	Forms part of the polypeptide exit tunnel
H2Q98_RS06190	COG1960	acyl-CoA dehydrogenase activity
H2Q98_RS06195	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H2Q98_RS06225	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H2Q98_RS06230	COG0339	signal peptide processing
H2Q98_RS06235	COG0557	exoribonuclease II activity
H2Q98_RS06285	COG0179	Fumarylacetoacetate (FAA) hydrolase
H2Q98_RS06290	COG1295	ribonuclease BN
H2Q98_RS06325	COG1702	phosphate starvation-inducible protein PhoH
H2Q98_RS06335	COG0741	lytic transglycosylase activity
H2Q98_RS06335	COG1196	nuclear chromosome segregation
H2Q98_RS06335	COG0739	heme binding
H2Q98_RS06355	COG3328	transposase activity
H2Q98_RS06370	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H2Q98_RS06375	COG1183	phosphatidylcholine synthase activity
H2Q98_RS06420	COG1960	acyl-CoA dehydrogenase activity
H2Q98_RS06425	COG1309	transcriptional regulator
H2Q98_RS06440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H2Q98_RS06445	COG1960	acyl-CoA dehydrogenase activity
H2Q98_RS06475	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS06485	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS06495	COG2969	positive regulation of protein catabolic process
H2Q98_RS06500	COG0625	glutathione transferase activity
H2Q98_RS06505	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H2Q98_RS06510	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H2Q98_RS06515	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H2Q98_RS06520	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H2Q98_RS06525	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H2Q98_RS06545	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H2Q98_RS06555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H2Q98_RS06560	COG1408	metallophosphoesterase
H2Q98_RS06565	COG2885	chlorophyll binding
H2Q98_RS06565	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H2Q98_RS06570	COG2199	diguanylate cyclase activity
H2Q98_RS06640	COG1607	acyl-coa hydrolase
H2Q98_RS06675	COG2350	Protein conserved in bacteria
H2Q98_RS06690	COG3781	membrane
H2Q98_RS06700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H2Q98_RS06705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H2Q98_RS06715	COG1862	Preprotein translocase
H2Q98_RS06750	COG0784	Response regulator, receiver
H2Q98_RS06750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2Q98_RS06750	COG2198	Histidine kinase
H2Q98_RS06750	COG2205	protein histidine kinase activity
H2Q98_RS06755	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H2Q98_RS06770	COG0726	polysaccharide deacetylase
H2Q98_RS06785	COG1216	Glycosyl transferase, family 2
H2Q98_RS06835	COG0625	glutathione transferase activity
H2Q98_RS06840	COG0583	DNA-binding transcription factor activity
H2Q98_RS06845	COG1960	acyl-CoA dehydrogenase activity
H2Q98_RS06850	COG1960	acyl-CoA dehydrogenase activity
H2Q98_RS06860	COG2205	protein histidine kinase activity
H2Q98_RS06865	COG0745	RESPONSE REGULATOR receiver
H2Q98_RS06875	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H2Q98_RS06895	COG2096	Adenosyltransferase
H2Q98_RS06900	COG4206	TonB-dependent receptor
H2Q98_RS06945	COG0285	dihydrofolate synthase activity
H2Q98_RS06965	COG0450	alkyl hydroperoxide reductase
H2Q98_RS06980	COG0477	Major facilitator Superfamily
H2Q98_RS06985	COG1272	protein, Hemolysin III
H2Q98_RS06995	COG2153	protein acetylation
H2Q98_RS07015	COG0183	Belongs to the thiolase family
H2Q98_RS07020	COG2207	Transcriptional regulator
H2Q98_RS07040	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2Q98_RS07060	COG0183	Belongs to the thiolase family
H2Q98_RS07070	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H2Q98_RS07070	COG2885	chlorophyll binding
H2Q98_RS07080	COG1690	Belongs to the RtcB family
H2Q98_RS07085	COG0833	amino acid
H2Q98_RS07095	COG2233	PERMEase
H2Q98_RS07100	COG1217	gtp-binding protein TYPA
H2Q98_RS07125	COG2094	Belongs to the DNA glycosylase MPG family
H2Q98_RS07130	COG4772	TonB-dependent receptor
H2Q98_RS07135	COG1902	pentaerythritol trinitrate reductase activity
H2Q98_RS07140	COG0679	Auxin Efflux Carrier
H2Q98_RS07150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H2Q98_RS07155	COG0354	folic acid binding
H2Q98_RS07175	COG2233	PERMEase
H2Q98_RS07180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2Q98_RS07185	COG0251	oxidation-reduction process
H2Q98_RS07190	COG1335	isochorismatase
H2Q98_RS07195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2Q98_RS07200	COG0778	Nitroreductase
H2Q98_RS07205	COG0596	Alpha beta hydrolase
H2Q98_RS07210	COG3189	MarR family transcriptional regulator
H2Q98_RS07215	COG2824	Alkylphosphonate utilization operon protein PhnA
H2Q98_RS07220	COG3422	double-strand break repair
H2Q98_RS07245	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS07270	COG0840	transmembrane signaling receptor activity
H2Q98_RS07290	COG5510	response to toxic substance
H2Q98_RS07300	COG2832	Protein of unknown function (DUF454)
H2Q98_RS07305	COG1376	ErfK ybiS ycfS ynhG family protein
H2Q98_RS07345	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H2Q98_RS07355	COG1289	transmembrane transporter activity
H2Q98_RS07360	COG2814	Major facilitator Superfamily
H2Q98_RS07380	COG1115	amino acid carrier protein
H2Q98_RS07385	COG1752	Esterase of the alpha-beta hydrolase superfamily
H2Q98_RS07390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H2Q98_RS07395	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H2Q98_RS07400	COG3590	peptidase
H2Q98_RS07425	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H2Q98_RS07435	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H2Q98_RS07440	COG1077	Cell shape determining protein MreB Mrl
H2Q98_RS07445	COG1792	Involved in formation and maintenance of cell shape
H2Q98_RS07450	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H2Q98_RS07455	COG0424	maF-like protein
H2Q98_RS07460	COG1530	ribonuclease E activity
H2Q98_RS07470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2Q98_RS07490	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2Q98_RS07515	COG2207	Transcriptional regulator
H2Q98_RS07545	COG3046	protein related to deoxyribodipyrimidine photolyase
H2Q98_RS07555	COG1113	amino acid transport
H2Q98_RS07560	COG2828	Protein conserved in bacteria
H2Q98_RS07565	COG0142	geranyltranstransferase activity
H2Q98_RS07570	COG2315	Protein conserved in bacteria
H2Q98_RS07585	COG1752	Esterase of the alpha-beta hydrolase superfamily
H2Q98_RS07610	COG2194	sulfuric ester hydrolase activity
H2Q98_RS07615	COG0745	RESPONSE REGULATOR receiver
H2Q98_RS07620	COG0642	Histidine kinase
H2Q98_RS07635	COG0004	ammonium transporteR
H2Q98_RS07640	COG0583	DNA-binding transcription factor activity
H2Q98_RS07665	COG0525	valine-tRNA ligase activity
H2Q98_RS07675	COG1028	Short-chain dehydrogenase reductase Sdr
H2Q98_RS07685	COG0393	Putative heavy-metal-binding
H2Q98_RS07690	COG0393	Putative heavy-metal-binding
H2Q98_RS07695	COG1538	Outer membrane efflux protein
H2Q98_RS07705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2Q98_RS07710	COG0671	phosphoesterase, PA-phosphatase related
H2Q98_RS07735	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H2Q98_RS07750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H2Q98_RS07750	COG1648	precorrin-2 dehydrogenase activity
H2Q98_RS07755	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H2Q98_RS07790	COG0531	amino acid
H2Q98_RS07805	COG0321	lipoyl(octanoyl) transferase activity
H2Q98_RS07810	COG2921	Belongs to the UPF0250 family
H2Q98_RS07850	COG2009	succinate dehydrogenase
H2Q98_RS07855	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H2Q98_RS07860	COG1053	succinate dehydrogenase
H2Q98_RS07865	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H2Q98_RS07890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2Q98_RS07910	COG2354	Protein conserved in bacteria
H2Q98_RS07915	COG2321	neutral zinc metallopeptidase
H2Q98_RS07935	COG2843	Capsule synthesis protein
H2Q98_RS07955	COG0589	response to stress
H2Q98_RS07965	COG0251	oxidation-reduction process
H2Q98_RS07970	COG1309	transcriptional regulator
H2Q98_RS07985	COG0505	Belongs to the CarA family
H2Q98_RS08015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H2Q98_RS08020	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H2Q98_RS08060	COG2264	protein methyltransferase activity
H2Q98_RS08070	COG0477	Major facilitator Superfamily
H2Q98_RS08075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H2Q98_RS08090	COG1597	lipid kinase activity
H2Q98_RS08095	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H2Q98_RS08105	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS08130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2Q98_RS08135	COG0584	glycerophosphoryl diester phosphodiesterase
H2Q98_RS08155	COG0741	lytic transglycosylase activity
H2Q98_RS08175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H2Q98_RS08200	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS08215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2Q98_RS08220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2Q98_RS08225	COG0778	Nitroreductase
H2Q98_RS08240	COG1929	Belongs to the glycerate kinase type-1 family
H2Q98_RS08245	COG0243	molybdopterin cofactor binding
H2Q98_RS08250	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H2Q98_RS08255	COG3339	Conserved Protein
H2Q98_RS08280	COG1115	amino acid carrier protein
H2Q98_RS08285	COG1113	amino acid transport
H2Q98_RS08295	COG0019	diaminopimelate decarboxylase activity
H2Q98_RS08305	COG1280	lysine exporter protein (LysE YggA)
H2Q98_RS08310	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H2Q98_RS08340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2Q98_RS08375	COG4591	ABC-type transport system involved in lipoprotein release permease component
H2Q98_RS08380	COG1136	(ABC) transporter
H2Q98_RS08390	COG3328	transposase activity
H2Q98_RS08405	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H2Q98_RS08405	COG0616	signal peptide processing
H2Q98_RS08410	COG0596	Alpha beta hydrolase
H2Q98_RS08415	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H2Q98_RS08425	COG0628	permease
H2Q98_RS08460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H2Q98_RS08480	COG0823	Involved in the tonB-independent uptake of proteins
H2Q98_RS08500	COG0824	Thioesterase
H2Q98_RS08505	COG1473	amidohydrolase
H2Q98_RS08525	COG0047	phosphoribosylformylglycinamidine synthase activity
H2Q98_RS08525	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H2Q98_RS08530	COG2814	Major facilitator Superfamily
H2Q98_RS08535	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H2Q98_RS08540	COG1024	Enoyl-CoA hydratase
H2Q98_RS08545	COG1051	belongs to the nudix hydrolase family
H2Q98_RS08545	COG1056	cytidyltransferase-related domain
H2Q98_RS08560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H2Q98_RS08575	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H2Q98_RS08590	COG4625	pathogenesis
H2Q98_RS08595	COG0583	DNA-binding transcription factor activity
H2Q98_RS08600	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H2Q98_RS08605	COG4208	sulfate ABC transporter
H2Q98_RS08610	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H2Q98_RS08620	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H2Q98_RS08625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H2Q98_RS08630	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H2Q98_RS08650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2Q98_RS08660	COG0481	GTPase activity
H2Q98_RS08665	COG0681	Belongs to the peptidase S26 family
H2Q98_RS08675	COG0571	ribonuclease III activity
H2Q98_RS08680	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H2Q98_RS08695	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H2Q98_RS08705	COG4221	oxidoreductase activity
H2Q98_RS08735	COG0436	Aminotransferase
H2Q98_RS08755	COG0556	nucleotide-excision repair
H2Q98_RS08765	COG2962	Rard protein
H2Q98_RS08810	COG2070	2-Nitropropane dioxygenase
H2Q98_RS08825	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H2Q98_RS08840	COG1215	transferase activity, transferring glycosyl groups
H2Q98_RS08855	COG0415	Belongs to the DNA photolyase family
H2Q98_RS08865	COG1252	NADH dehydrogenase
H2Q98_RS08870	COG1686	Belongs to the peptidase S11 family
H2Q98_RS08885	COG1187	pseudouridine synthase activity
H2Q98_RS08900	COG0477	Major facilitator Superfamily
H2Q98_RS08905	COG0583	DNA-binding transcription factor activity
H2Q98_RS08910	COG1823	symporter activity
H2Q98_RS08920	COG0612	Peptidase, M16
H2Q98_RS08945	COG0352	thiamine-phosphate diphosphorylase activity
H2Q98_RS08980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2Q98_RS08995	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H2Q98_RS09000	COG0076	glutamate decarboxylase activity
H2Q98_RS09010	COG1522	sequence-specific DNA binding
H2Q98_RS09015	COG3961	Belongs to the TPP enzyme family
H2Q98_RS09020	COG1113	amino acid transport
H2Q98_RS09025	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H2Q98_RS09030	COG0573	inorganic phosphate transmembrane transporter activity
H2Q98_RS09040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H2Q98_RS09045	COG0616	signal peptide processing
H2Q98_RS09055	COG3328	transposase activity
H2Q98_RS09090	COG3328	transposase activity
H2Q98_RS09095	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H2Q98_RS09100	COG1686	Belongs to the peptidase S11 family
H2Q98_RS09125	COG0583	DNA-binding transcription factor activity
H2Q98_RS09130	COG1067	ATP-dependent peptidase activity
H2Q98_RS09170	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H2Q98_RS09175	COG1966	Carbon starvation protein
H2Q98_RS09180	COG2879	small protein
H2Q98_RS09220	COG3328	transposase activity
H2Q98_RS09235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2Q98_RS09240	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2Q98_RS09245	COG4605	iron ion homeostasis
H2Q98_RS09250	COG4604	ABC transporter, ATP-binding protein
H2Q98_RS09255	COG4607	ABC-type enterochelin transport system periplasmic component
H2Q98_RS09260	COG4774	siderophore transport
H2Q98_RS09270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2Q98_RS09275	COG1021	2,3-dihydroxybenzoate-AMP ligase
H2Q98_RS09280	COG1535	isochorismatase
H2Q98_RS09280	COG3433	isochorismatase activity
H2Q98_RS09290	COG1132	(ABC) transporter
H2Q98_RS09295	COG1132	(ABC) transporter
H2Q98_RS09300	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H2Q98_RS09305	COG2977	Belongs to the P-Pant transferase superfamily
H2Q98_RS09310	COG1169	isochorismate synthase
H2Q98_RS09325	COG3739	integral membrane protein
H2Q98_RS09345	COG0302	gtp cyclohydrolase
H2Q98_RS09355	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H2Q98_RS09365	COG2840	Smr protein MutS2
H2Q98_RS09400	COG0512	Glutamine amidotransferase of anthranilate synthase
H2Q98_RS09455	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H2Q98_RS09460	COG4197	protein conserved in bacteria, prophage-related
H2Q98_RS09705	COG3772	lysozyme
H2Q98_RS09710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2Q98_RS09725	COG0582	viral genome integration into host DNA
H2Q98_RS09740	COG0174	glutamine synthetase
H2Q98_RS09750	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H2Q98_RS09785	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H2Q98_RS09790	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H2Q98_RS09795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2Q98_RS09815	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H2Q98_RS09820	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H2Q98_RS09825	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H2Q98_RS09840	COG1960	acyl-CoA dehydrogenase activity
H2Q98_RS09845	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H2Q98_RS09850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2Q98_RS09860	COG2223	nitrite transmembrane transporter activity
H2Q98_RS09870	COG0024	Methionine aminopeptidase
H2Q98_RS09875	COG0052	Belongs to the universal ribosomal protein uS2 family
H2Q98_RS09915	COG2951	lytic endotransglycosylase activity
H2Q98_RS09920	COG0772	Belongs to the SEDS family
H2Q98_RS09935	COG0842	Transport permease protein
H2Q98_RS09940	COG1131	(ABC) transporter
H2Q98_RS09985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2Q98_RS09995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2Q98_RS10000	COG4215	(ABC) transporter
H2Q98_RS10005	COG4160	amino acid transport
H2Q98_RS10010	COG4598	ABC transporter
H2Q98_RS10020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H2Q98_RS10025	COG0826	peptidase U32
H2Q98_RS10030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2Q98_RS10035	COG0384	phenazine biosynthesis protein PhzF
H2Q98_RS10045	COG1720	tRNA m6t6A37 methyltransferase activity
H2Q98_RS10055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H2Q98_RS10070	COG0642	Histidine kinase
H2Q98_RS10080	COG0494	nUDIX hydrolase
H2Q98_RS10090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H2Q98_RS10095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H2Q98_RS10100	COG3139	Protein of unknown function (DUF1315)
H2Q98_RS10105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H2Q98_RS10110	COG1301	dicarboxylic acid transport
H2Q98_RS10115	COG1960	acyl-CoA dehydrogenase activity
H2Q98_RS10130	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H2Q98_RS10140	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H2Q98_RS10145	COG2195	Cleaves the N-terminal amino acid of tripeptides
H2Q98_RS10165	COG1690	Belongs to the RtcB family
H2Q98_RS10170	COG1234	tRNA 3'-trailer cleavage
H2Q98_RS10175	COG4650	regulator
H2Q98_RS10205	COG2363	Small membrane protein
H2Q98_RS10225	COG0513	Belongs to the DEAD box helicase family
H2Q98_RS10235	COG0778	Nitroreductase
H2Q98_RS10265	COG1286	toxin biosynthetic process
H2Q98_RS10290	COG4783	chaperone-mediated protein folding
H2Q98_RS10295	COG1610	YqeY-like protein
H2Q98_RS10350	COG1278	Cold shock
H2Q98_RS10365	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS10375	COG3243	poly(R)-hydroxyalkanoic acid synthase
H2Q98_RS10380	COG0786	glutamate:sodium symporter activity
H2Q98_RS10385	COG0475	glutathione-regulated potassium exporter activity
H2Q98_RS10385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H2Q98_RS10390	COG1028	Short-chain dehydrogenase reductase Sdr
H2Q98_RS10440	COG1309	transcriptional regulator
H2Q98_RS10450	COG2985	domain, Protein
H2Q98_RS10465	COG2995	paraquat-inducible protein a
H2Q98_RS10470	COG3008	intermembrane lipid transfer
H2Q98_RS10470	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H2Q98_RS10480	COG2351	hydroxyisourate hydrolase activity
H2Q98_RS10520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H2Q98_RS10530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H2Q98_RS10535	COG0642	Histidine kinase
H2Q98_RS10540	COG0745	RESPONSE REGULATOR receiver
H2Q98_RS10555	COG1794	racemase activity, acting on amino acids and derivatives
H2Q98_RS10595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2Q98_RS10600	COG2011	ABC-type metal ion transport system permease component
H2Q98_RS10605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H2Q98_RS10615	COG0151	Belongs to the GarS family
H2Q98_RS10625	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H2Q98_RS10655	COG2308	Evidence 4 Homologs of previously reported genes of
H2Q98_RS10665	COG1305	Transglutaminase-like
H2Q98_RS10675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H2Q98_RS10680	COG0305	Participates in initiation and elongation during chromosome replication
H2Q98_RS10705	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H2Q98_RS10710	COG1845	cytochrome c oxidase, subunit III
H2Q98_RS10715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H2Q98_RS10750	COG0583	DNA-binding transcription factor activity
H2Q98_RS10765	COG2890	protein-(glutamine-N5) methyltransferase activity
H2Q98_RS10770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2Q98_RS10775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2Q98_RS10790	COG1960	acyl-CoA dehydrogenase activity
H2Q98_RS10795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2Q98_RS10810	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H2Q98_RS10820	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H2Q98_RS10825	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H2Q98_RS10830	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H2Q98_RS10835	COG2205	protein histidine kinase activity
H2Q98_RS10840	COG0745	RESPONSE REGULATOR receiver
H2Q98_RS10845	COG0174	glutamine synthetase
H2Q98_RS10860	COG0477	Major facilitator Superfamily
H2Q98_RS10865	COG0729	surface antigen
H2Q98_RS10890	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS10900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H2Q98_RS10905	COG2814	Major facilitator Superfamily
H2Q98_RS10915	COG0583	DNA-binding transcription factor activity
H2Q98_RS10930	COG1187	pseudouridine synthase activity
H2Q98_RS10950	COG0802	atpase or kinase
H2Q98_RS10955	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H2Q98_RS10965	COG1923	regulation of RNA biosynthetic process
H2Q98_RS10970	COG0697	spore germination
H2Q98_RS10985	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H2Q98_RS10995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H2Q98_RS11000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H2Q98_RS11000	COG0519	Catalyzes the synthesis of GMP from XMP
H2Q98_RS11005	COG4302	ethanolamine ammonia-lyase activity
H2Q98_RS11010	COG4303	Ethanolamine ammonia lyase large subunit
H2Q98_RS11015	COG0531	amino acid
H2Q98_RS11035	COG1454	alcohol dehydrogenase
H2Q98_RS11040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2Q98_RS11065	COG0308	aminopeptidase N
H2Q98_RS11075	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS11125	COG1605	Chorismate mutase
H2Q98_RS11140	COG4772	TonB-dependent receptor
H2Q98_RS11145	COG4774	siderophore transport
H2Q98_RS11200	COG3772	lysozyme
H2Q98_RS11225	COG0583	DNA-binding transcription factor activity
H2Q98_RS11250	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS11270	COG0488	(ABC) transporter
H2Q98_RS11275	COG0589	response to stress
H2Q98_RS11285	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS11300	COG3135	benzoate transporter
H2Q98_RS11305	COG1522	sequence-specific DNA binding
H2Q98_RS11315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H2Q98_RS11320	COG0583	DNA-binding transcription factor activity
H2Q98_RS11330	COG0183	Belongs to the thiolase family
H2Q98_RS11335	COG1028	Short-chain dehydrogenase reductase Sdr
H2Q98_RS11340	COG2030	dehydratase
H2Q98_RS11345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H2Q98_RS11370	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H2Q98_RS11380	COG0824	Thioesterase
H2Q98_RS11385	COG1454	alcohol dehydrogenase
H2Q98_RS11400	COG1335	isochorismatase
H2Q98_RS11415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H2Q98_RS11445	COG0069	glutamate synthase activity
H2Q98_RS11470	COG2814	Major facilitator Superfamily
H2Q98_RS11485	COG0511	ligase activity, forming carbon-carbon bonds
H2Q98_RS11510	COG4264	IucA IucC family
H2Q98_RS11520	COG4264	IucA IucC family
H2Q98_RS11525	COG2423	ornithine cyclodeaminase activity
H2Q98_RS11530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H2Q98_RS11535	COG1116	anion transmembrane transporter activity
H2Q98_RS11535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2Q98_RS11550	COG2146	nitrite reductase [NAD(P)H] activity
H2Q98_RS11550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2Q98_RS11555	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2Q98_RS11560	COG0243	molybdopterin cofactor binding
H2Q98_RS11570	COG0243	molybdopterin cofactor binding
H2Q98_RS11575	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H2Q98_RS11590	COG0521	Mo-molybdopterin cofactor biosynthetic process
H2Q98_RS11590	COG0315	cyclic pyranopterin monophosphate synthase activity
H2Q98_RS11595	COG0303	'Molybdopterin
H2Q98_RS11605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2Q98_RS11610	COG0697	spore germination
H2Q98_RS11635	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H2Q98_RS11705	COG2204	response regulator
H2Q98_RS11710	COG3852	Histidine kinase
H2Q98_RS11735	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H2Q98_RS11740	COG0575	Belongs to the CDS family
H2Q98_RS11775	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H2Q98_RS11790	COG2137	regulation of response to DNA damage stimulus
H2Q98_RS11800	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H2Q98_RS11805	COG1011	Hydrolase
H2Q98_RS11885	COG1484	DNA-dependent DNA replication
H2Q98_RS11955	COG3755	Protein conserved in bacteria
H2Q98_RS12020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2Q98_RS12050	COG1522	sequence-specific DNA binding
H2Q98_RS12060	COG1113	amino acid transport
H2Q98_RS12075	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS12085	COG0659	secondary active sulfate transmembrane transporter activity
H2Q98_RS12110	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS12125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2Q98_RS12125	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H2Q98_RS12125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2Q98_RS12130	COG1105	Belongs to the carbohydrate kinase PfkB family
H2Q98_RS12135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2Q98_RS12135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H2Q98_RS12155	COG3193	protein, possibly involved in utilization of glycolate and propanediol
H2Q98_RS12165	COG0024	Methionine aminopeptidase
H2Q98_RS12170	COG0583	DNA-binding transcription factor activity
H2Q98_RS12180	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H2Q98_RS12185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H2Q98_RS12190	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H2Q98_RS12190	COG0517	IMP dehydrogenase activity
H2Q98_RS12215	COG0552	protein localization to endoplasmic reticulum
H2Q98_RS12240	COG4890	Cyd operon protein YbgT
H2Q98_RS12245	COG1294	oxidase, subunit
H2Q98_RS12260	COG1585	Membrane protein implicated in regulation of membrane protease activity
H2Q98_RS12270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2Q98_RS12285	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H2Q98_RS12290	COG0569	domain protein
H2Q98_RS12295	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H2Q98_RS12325	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H2Q98_RS12330	COG0542	response to heat
H2Q98_RS12355	COG0446	pyridine nucleotide-disulphide oxidoreductase
H2Q98_RS12355	COG1902	pentaerythritol trinitrate reductase activity
H2Q98_RS12395	COG0148	phosphopyruvate hydratase activity
H2Q98_RS12400	COG2323	membrane
H2Q98_RS12410	COG4773	Receptor
H2Q98_RS12415	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H2Q98_RS12425	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H2Q98_RS12430	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H2Q98_RS12435	COG0183	Belongs to the thiolase family
H2Q98_RS12440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H2Q98_RS12445	COG0596	Alpha beta hydrolase
H2Q98_RS12450	COG2271	Major facilitator Superfamily
H2Q98_RS12455	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H2Q98_RS12460	COG3485	protocatechuate 3,4-dioxygenase
H2Q98_RS12465	COG3485	protocatechuate 3,4-dioxygenase
H2Q98_RS12470	COG0710	3-dehydroquinate dehydratase activity
H2Q98_RS12475	COG3420	alginic acid biosynthetic process
H2Q98_RS12480	COG3659	wide pore channel activity
H2Q98_RS12485	COG4993	Dehydrogenase
H2Q98_RS12495	COG2391	methyltransferase activity
H2Q98_RS12510	COG1414	Transcriptional regulator
H2Q98_RS12515	COG0583	DNA-binding transcription factor activity
H2Q98_RS12520	COG1960	acyl-CoA dehydrogenase activity
H2Q98_RS12545	COG2814	Major facilitator Superfamily
H2Q98_RS12555	COG0154	amidase activity
H2Q98_RS12575	COG4638	Rieske (2fe-2S)
H2Q98_RS12585	COG1028	Short-chain dehydrogenase reductase Sdr
H2Q98_RS12595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2Q98_RS12605	COG3733	amine oxidase
H2Q98_RS12615	COG1012	belongs to the aldehyde dehydrogenase family
H2Q98_RS12620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2Q98_RS12625	COG0183	Belongs to the thiolase family
H2Q98_RS12630	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H2Q98_RS12635	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H2Q98_RS12645	COG4829	muconolactone delta-isomerase
H2Q98_RS12650	COG4948	Mandelate Racemase Muconate Lactonizing
H2Q98_RS12655	COG0583	DNA-binding transcription factor activity
H2Q98_RS12665	COG2186	Transcriptional regulator
H2Q98_RS12685	COG1012	belongs to the aldehyde dehydrogenase family
H2Q98_RS12690	COG2351	hydroxyisourate hydrolase activity
H2Q98_RS12695	COG2233	PERMEase
H2Q98_RS12705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2Q98_RS12710	COG2186	Transcriptional regulator
H2Q98_RS12720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2Q98_RS12730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2Q98_RS12750	COG0446	pyridine nucleotide-disulphide oxidoreductase
H2Q98_RS12750	COG1902	pentaerythritol trinitrate reductase activity
H2Q98_RS12790	COG1309	transcriptional regulator
H2Q98_RS12795	COG0583	DNA-binding transcription factor activity
H2Q98_RS12800	COG1028	Short-chain dehydrogenase reductase Sdr
H2Q98_RS12805	COG1028	Short-chain dehydrogenase reductase Sdr
H2Q98_RS12810	COG1028	Short-chain dehydrogenase reductase Sdr
H2Q98_RS12820	COG1960	acyl-CoA dehydrogenase activity
H2Q98_RS12830	COG0318	PFAM AMP-dependent synthetase and ligase
H2Q98_RS12840	COG3328	transposase activity
H2Q98_RS12875	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS12920	COG0583	DNA-binding transcription factor activity
H2Q98_RS12945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H2Q98_RS12950	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H2Q98_RS12965	COG2831	hemolysin activation secretion protein
H2Q98_RS13025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2Q98_RS13030	COG1120	ATPase activity
H2Q98_RS13040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H2Q98_RS13090	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H2Q98_RS13150	COG4628	conserved protein (DUF2132)
H2Q98_RS13250	COG3539	Fimbrial protein
H2Q98_RS13275	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H2Q98_RS13285	COG0753	catalase activity
H2Q98_RS13305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H2Q98_RS13315	COG2205	protein histidine kinase activity
H2Q98_RS13320	COG0745	RESPONSE REGULATOR receiver
H2Q98_RS13325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2Q98_RS13330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2Q98_RS13385	COG3433	isochorismatase activity
H2Q98_RS13385	COG1535	isochorismatase
H2Q98_RS13390	COG1028	Short-chain dehydrogenase reductase Sdr
H2Q98_RS13395	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H2Q98_RS13400	COG4149	molybdate abc transporter
H2Q98_RS13405	COG0725	ABC transporter, periplasmic molybdate-binding protein
H2Q98_RS13415	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS13425	COG4638	Rieske (2fe-2S)
H2Q98_RS13430	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H2Q98_RS13435	COG0543	2 iron, 2 sulfur cluster binding
H2Q98_RS13435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2Q98_RS13450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2Q98_RS13460	COG1028	Short-chain dehydrogenase reductase Sdr
H2Q98_RS13480	COG2207	Transcriptional regulator
H2Q98_RS13485	COG1028	Short-chain dehydrogenase reductase Sdr
H2Q98_RS13490	COG2610	gluconate transmembrane transporter activity
H2Q98_RS13510	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS13525	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS13540	COG0583	DNA-binding transcription factor activity
H2Q98_RS13555	COG2031	fatty acid transporter
H2Q98_RS13560	COG0183	Belongs to the thiolase family
H2Q98_RS13565	COG0583	DNA-binding transcription factor activity
H2Q98_RS13570	COG0583	DNA-binding transcription factor activity
H2Q98_RS13585	COG1027	Aspartate ammonia-lyase
H2Q98_RS13595	COG0477	Major facilitator Superfamily
H2Q98_RS13605	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H2Q98_RS13610	COG1733	regulation of RNA biosynthetic process
H2Q98_RS13615	COG3708	Transcriptional regulator
H2Q98_RS13615	COG2207	Transcriptional regulator
H2Q98_RS13630	COG0730	response to heat
H2Q98_RS13650	COG3781	membrane
H2Q98_RS13655	COG1063	alcohol dehydrogenase
H2Q98_RS13665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2Q98_RS13670	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2Q98_RS13675	COG0022	dehydrogenase e1 component
H2Q98_RS13680	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H2Q98_RS13685	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H2Q98_RS13695	COG3328	transposase activity
H2Q98_RS13710	COG3706	GGDEF domain
H2Q98_RS13720	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS13735	COG0133	tryptophan synthase activity
H2Q98_RS13745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H2Q98_RS13775	COG0583	DNA-binding transcription factor activity
H2Q98_RS13780	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H2Q98_RS13790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H2Q98_RS13850	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H2Q98_RS13855	COG4773	Receptor
H2Q98_RS13880	COG0730	response to heat
H2Q98_RS13885	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H2Q98_RS13905	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H2Q98_RS13920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H2Q98_RS13930	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H2Q98_RS13945	COG1960	acyl-CoA dehydrogenase activity
H2Q98_RS13950	COG1960	acyl-CoA dehydrogenase activity
H2Q98_RS13955	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2Q98_RS13960	COG2207	Transcriptional regulator
H2Q98_RS13965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H2Q98_RS13970	COG0776	regulation of translation
H2Q98_RS13995	COG0822	iron-sulfur transferase activity
H2Q98_RS14000	COG0316	Belongs to the HesB IscA family
H2Q98_RS14030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H2Q98_RS14050	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H2Q98_RS14055	COG0702	epimerase
H2Q98_RS14095	COG0601	transmembrane transport
H2Q98_RS14100	COG0339	signal peptide processing
H2Q98_RS14105	COG4166	transmembrane transport
H2Q98_RS14150	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H2Q98_RS14155	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H2Q98_RS14170	COG2431	L-lysine efflux transmembrane transporter activity
H2Q98_RS14185	COG0776	regulation of translation
H2Q98_RS14250	COG0084	hydrolase, TatD family'
H2Q98_RS14270	COG1663	tetraacyldisaccharide 4'-kinase activity
H2Q98_RS14275	COG1132	(ABC) transporter
H2Q98_RS14285	COG0811	peptide transport
H2Q98_RS14290	COG1475	DNA binding
H2Q98_RS14295	COG1192	Involved in chromosome partitioning
H2Q98_RS14305	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H2Q98_RS14310	COG3178	'Phosphotransferase
H2Q98_RS14320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H2Q98_RS14345	COG0424	maF-like protein
H2Q98_RS14350	COG2850	peptidyl-arginine hydroxylation
H2Q98_RS14360	COG0640	Transcriptional regulator
H2Q98_RS14370	COG3619	membrane
H2Q98_RS14375	COG3122	Protein conserved in bacteria
H2Q98_RS14380	COG1132	(ABC) transporter
H2Q98_RS14400	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H2Q98_RS14405	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H2Q98_RS14415	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H2Q98_RS14415	COG0506	proline dehydrogenase activity
H2Q98_RS14415	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H2Q98_RS14425	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS14445	COG3698	Phosphodiester glycosidase
H2Q98_RS14455	COG2353	YceI-like domain
H2Q98_RS14465	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H2Q98_RS14510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H2Q98_RS14510	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H2Q98_RS14535	COG3539	Fimbrial protein
H2Q98_RS14555	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS14570	COG0583	DNA-binding transcription factor activity
H2Q98_RS14575	COG0697	spore germination
H2Q98_RS14585	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H2Q98_RS14595	COG0583	DNA-binding transcription factor activity
H2Q98_RS14610	COG1309	transcriptional regulator
H2Q98_RS14625	COG1522	sequence-specific DNA binding
H2Q98_RS14635	COG1126	abc transporter atp-binding protein
H2Q98_RS14640	COG0765	amino acid transport
H2Q98_RS14645	COG0765	amino acid transport
H2Q98_RS14675	COG1464	Belongs to the NlpA lipoprotein family
H2Q98_RS14685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H2Q98_RS14690	COG2011	ABC-type metal ion transport system permease component
H2Q98_RS14695	COG0012	GTP binding
H2Q98_RS14720	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H2Q98_RS14755	COG1917	Cupin 2, conserved barrel domain protein
H2Q98_RS14755	COG2207	Transcriptional regulator
H2Q98_RS14760	COG0386	Belongs to the glutathione peroxidase family
H2Q98_RS14770	COG0436	Aminotransferase
H2Q98_RS14775	COG1301	dicarboxylic acid transport
H2Q98_RS14810	COG3634	alkyl hydroperoxide reductase activity
H2Q98_RS14825	COG0583	DNA-binding transcription factor activity
H2Q98_RS14830	COG0431	NADPH-dependent FMN reductase
H2Q98_RS14835	COG0798	PFAM Bile acid sodium symporter
H2Q98_RS14845	COG0640	Transcriptional regulator
H2Q98_RS14860	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H2Q98_RS14870	COG0583	DNA-binding transcription factor activity
H2Q98_RS14900	COG1271	oxidase subunit
H2Q98_RS14905	COG1294	oxidase, subunit
H2Q98_RS14915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2Q98_RS14935	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H2Q98_RS14955	COG3052	prosthetic group binding
H2Q98_RS14960	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H2Q98_RS14985	COG1346	cytolysis
H2Q98_RS14995	COG0583	DNA-binding transcription factor activity
H2Q98_RS15000	COG0625	glutathione transferase activity
H2Q98_RS15005	COG0625	glutathione transferase activity
H2Q98_RS15025	COG0583	DNA-binding transcription factor activity
H2Q98_RS15040	COG1045	serine acetyltransferase
H2Q98_RS15045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H2Q98_RS15050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H2Q98_RS15055	COG1280	lysine exporter protein (LysE YggA)
H2Q98_RS15070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2Q98_RS15075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2Q98_RS15085	COG0765	amino acid transport
H2Q98_RS15090	COG0765	amino acid transport
H2Q98_RS15110	COG0784	Response regulator, receiver
H2Q98_RS15110	COG2205	protein histidine kinase activity
H2Q98_RS15130	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H2Q98_RS15150	COG1028	Short-chain dehydrogenase reductase Sdr
H2Q98_RS15170	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS15200	COG0583	DNA-binding transcription factor activity
H2Q98_RS15210	COG2814	Major facilitator Superfamily
H2Q98_RS15225	COG0318	PFAM AMP-dependent synthetase and ligase
H2Q98_RS15230	COG1309	transcriptional regulator
H2Q98_RS15235	COG1960	acyl-CoA dehydrogenase activity
H2Q98_RS15240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H2Q98_RS15245	COG1024	Enoyl-CoA hydratase
H2Q98_RS15250	COG4770	biotin carboxylase activity
H2Q98_RS15260	COG0583	DNA-binding transcription factor activity
H2Q98_RS15275	COG1960	acyl-CoA dehydrogenase activity
H2Q98_RS15285	COG2814	Major facilitator Superfamily
H2Q98_RS15295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H2Q98_RS15300	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H2Q98_RS15305	COG2814	Major facilitator Superfamily
H2Q98_RS15310	COG1960	acyl-CoA dehydrogenase activity
H2Q98_RS15315	COG1024	Enoyl-CoA hydratase
H2Q98_RS15320	COG1028	Short-chain dehydrogenase reductase Sdr
H2Q98_RS15325	COG1250	3-hydroxyacyl-CoA dehydrogenase
H2Q98_RS15330	COG0183	Belongs to the thiolase family
H2Q98_RS15340	COG2814	Major facilitator Superfamily
H2Q98_RS15350	COG1024	Enoyl-CoA hydratase
H2Q98_RS15365	COG1960	acyl-CoA dehydrogenase activity
H2Q98_RS15370	COG2814	Major facilitator Superfamily
H2Q98_RS15375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H2Q98_RS15380	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H2Q98_RS15395	COG3842	ATPase activity
H2Q98_RS15400	COG1840	ABC-type Fe3 transport system, periplasmic component
H2Q98_RS15430	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS15440	COG1028	Short-chain dehydrogenase reductase Sdr
H2Q98_RS15445	COG0583	DNA-binding transcription factor activity
H2Q98_RS15450	COG2050	protein possibly involved in aromatic compounds catabolism
H2Q98_RS15460	COG3327	negative regulation of DNA-templated transcription, initiation
H2Q98_RS15465	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H2Q98_RS15470	COG0183	Belongs to the thiolase family
H2Q98_RS15475	COG1250	3-hydroxyacyl-CoA dehydrogenase
H2Q98_RS15480	COG1024	Enoyl-CoA hydratase
H2Q98_RS15485	COG1024	Enoyl-CoA hydratase
H2Q98_RS15490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2Q98_RS15495	COG2151	metal-sulfur cluster biosynthetic enzyme
H2Q98_RS15500	COG3396	Phenylacetate-CoA oxygenase
H2Q98_RS15505	COG3460	Phenylacetate-CoA oxygenase
H2Q98_RS15510	COG3396	Phenylacetate-CoA oxygenase
H2Q98_RS15515	COG1012	belongs to the aldehyde dehydrogenase family
H2Q98_RS15515	COG2030	dehydratase
H2Q98_RS15520	COG1760	l-serine dehydratase
H2Q98_RS15535	COG0789	Transcriptional regulator
H2Q98_RS15545	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H2Q98_RS15550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2Q98_RS15565	COG2807	transmembrane transport
H2Q98_RS15570	COG0590	tRNA wobble adenosine to inosine editing
H2Q98_RS15575	COG0666	response to abiotic stimulus
H2Q98_RS15620	COG1063	alcohol dehydrogenase
H2Q98_RS15625	COG1250	3-hydroxyacyl-CoA dehydrogenase
H2Q98_RS15660	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS15670	COG2831	hemolysin activation secretion protein
H2Q98_RS15675	COG0038	chloride channel
H2Q98_RS15680	COG4770	biotin carboxylase activity
H2Q98_RS15700	COG1914	H( )-stimulated, divalent metal cation uptake system
H2Q98_RS15715	COG1595	DNA-templated transcription, initiation
H2Q98_RS15725	COG3220	belongs to the UPF0276 family
H2Q98_RS15775	COG0531	amino acid
H2Q98_RS15780	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H2Q98_RS15795	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H2Q98_RS15810	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H2Q98_RS15820	COG4122	O-methyltransferase activity
H2Q98_RS15850	COG1538	Outer membrane efflux protein
H2Q98_RS15855	COG1137	ATPase activity
H2Q98_RS15860	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H2Q98_RS15870	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H2Q98_RS15890	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS15910	COG2814	Major facilitator Superfamily
H2Q98_RS15920	COG0668	transmembrane transport
H2Q98_RS15965	COG1309	transcriptional regulator
H2Q98_RS15975	COG2226	methyltransferase
H2Q98_RS15980	COG1011	Hydrolase
H2Q98_RS16005	COG1278	Cold shock
H2Q98_RS16010	COG1560	Kdo2-lipid A biosynthetic process
H2Q98_RS16015	COG1280	lysine exporter protein (LysE YggA)
H2Q98_RS16050	COG1570	exodeoxyribonuclease VII activity
H2Q98_RS16130	COG2871	sodium ion transport
H2Q98_RS16140	COG0583	DNA-binding transcription factor activity
H2Q98_RS16150	COG4638	Rieske (2fe-2S)
H2Q98_RS16155	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H2Q98_RS16160	COG0543	2 iron, 2 sulfur cluster binding
H2Q98_RS16160	COG0633	Ferredoxin
H2Q98_RS16165	COG1028	Short-chain dehydrogenase reductase Sdr
H2Q98_RS16170	COG3135	benzoate transporter
H2Q98_RS16180	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS16200	COG1643	Atp-dependent helicase
H2Q98_RS16225	COG3634	alkyl hydroperoxide reductase activity
H2Q98_RS16245	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H2Q98_RS16250	COG0625	glutathione transferase activity
H2Q98_RS16260	COG2885	chlorophyll binding
H2Q98_RS16285	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS16300	COG0542	response to heat
H2Q98_RS16315	COG1765	OsmC-like protein
H2Q98_RS16330	COG0667	Aldo Keto reductase
H2Q98_RS16345	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H2Q98_RS16355	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H2Q98_RS16365	COG0582	viral genome integration into host DNA
H2Q98_RS16380	COG3293	Transposase
H2Q98_RS16385	COG1063	alcohol dehydrogenase
H2Q98_RS16550	COG0527	aspartate kinase activity
H2Q98_RS16560	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H2Q98_RS16570	COG3038	cytochrome b561
H2Q98_RS16575	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H2Q98_RS16580	COG2252	PERMEase
H2Q98_RS16590	COG1741	Belongs to the pirin family
H2Q98_RS16595	COG1309	transcriptional regulator
H2Q98_RS16610	COG2072	flavoprotein involved in K transport
H2Q98_RS16615	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H2Q98_RS16620	COG0583	DNA-binding transcription factor activity
H2Q98_RS16635	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H2Q98_RS16665	COG1944	ATP diphosphatase activity
H2Q98_RS16685	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H2Q98_RS16700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2Q98_RS16710	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS16720	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H2Q98_RS16725	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS16740	COG2814	Major facilitator Superfamily
H2Q98_RS16745	COG1024	Enoyl-CoA hydratase
H2Q98_RS16760	COG1960	acyl-CoA dehydrogenase activity
H2Q98_RS16785	COG2186	Transcriptional regulator
H2Q98_RS16790	COG1012	belongs to the aldehyde dehydrogenase family
H2Q98_RS16800	COG4948	Mandelate Racemase Muconate Lactonizing
H2Q98_RS16805	COG2271	Major facilitator Superfamily
H2Q98_RS16810	COG2721	sulfolactate sulfo-lyase activity
H2Q98_RS16815	COG0697	spore germination
H2Q98_RS16835	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS16855	COG1012	belongs to the aldehyde dehydrogenase family
H2Q98_RS16875	COG0531	amino acid
H2Q98_RS16885	COG1113	amino acid transport
H2Q98_RS16920	COG2801	Transposase and inactivated derivatives
H2Q98_RS16930	COG4269	membrane
H2Q98_RS16950	COG1902	pentaerythritol trinitrate reductase activity
H2Q98_RS16950	COG0446	pyridine nucleotide-disulphide oxidoreductase
H2Q98_RS16960	COG3706	GGDEF domain
H2Q98_RS16960	COG2203	Gaf domain
H2Q98_RS16960	COG5001	Diguanylate cyclase
H2Q98_RS16960	COG4251	negative regulation of phosphorylation
H2Q98_RS16970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H2Q98_RS16995	COG4172	Belongs to the ABC transporter superfamily
H2Q98_RS17000	COG4239	(ABC) transporter, permease
H2Q98_RS17005	COG4174	ABC transporter (Permease)
H2Q98_RS17010	COG4166	transmembrane transport
H2Q98_RS17015	COG1388	LysM domain
H2Q98_RS17015	COG0741	lytic transglycosylase activity
H2Q98_RS17060	COG0583	DNA-binding transcription factor activity
H2Q98_RS17065	COG1279	arginine transmembrane transporter activity
H2Q98_RS17085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2Q98_RS17090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2Q98_RS17095	COG0006	proline dipeptidase activity
H2Q98_RS17135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H2Q98_RS17150	COG3384	dioxygenase
H2Q98_RS17160	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H2Q98_RS17165	COG2878	Part of a membrane complex involved in electron transport
H2Q98_RS17170	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H2Q98_RS17195	COG0768	penicillin binding
H2Q98_RS17200	COG0742	ribosomal rna small subunit methyltransferase
H2Q98_RS17215	COG0830	nickel cation binding
H2Q98_RS17225	COG0804	urea catabolic process
H2Q98_RS17255	COG3015	lipoprotein NlpE involved in copper resistance
H2Q98_RS17270	COG1253	flavin adenine dinucleotide binding
H2Q98_RS17275	COG2851	Citrate transporter
H2Q98_RS17325	COG1773	rubredoxin
H2Q98_RS17330	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2Q98_RS17335	COG2267	carboxylic ester hydrolase activity
H2Q98_RS17340	COG0583	DNA-binding transcription factor activity
H2Q98_RS17370	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H2Q98_RS17375	COG4181	ATPase activity
H2Q98_RS17420	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H2Q98_RS17440	COG0306	phosphate transporter
H2Q98_RS17465	COG2223	nitrite transmembrane transporter activity
H2Q98_RS17470	COG2207	Transcriptional regulator
H2Q98_RS17475	COG2066	Belongs to the glutaminase family
H2Q98_RS17480	COG0242	peptide deformylase activity
H2Q98_RS17485	COG0477	Major facilitator Superfamily
H2Q98_RS17495	COG0028	Belongs to the TPP enzyme family
H2Q98_RS17510	COG1028	Short-chain dehydrogenase reductase Sdr
H2Q98_RS17515	COG2267	carboxylic ester hydrolase activity
H2Q98_RS17525	COG2271	Major facilitator Superfamily
H2Q98_RS17540	COG1028	Short-chain dehydrogenase reductase Sdr
H2Q98_RS17560	COG1414	Transcriptional regulator
H2Q98_RS17575	COG1024	Enoyl-CoA hydratase
H2Q98_RS17585	COG1215	transferase activity, transferring glycosyl groups
H2Q98_RS17590	COG1649	PFAM Uncharacterised BCR, COG1649
H2Q98_RS17590	COG0726	polysaccharide deacetylase
H2Q98_RS17600	COG4681	YaeQ
H2Q98_RS17610	COG0523	cobalamin synthesis protein
H2Q98_RS17620	COG1607	acyl-coa hydrolase
H2Q98_RS17630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H2Q98_RS17635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H2Q98_RS17640	COG1309	transcriptional regulator
H2Q98_RS17665	COG2040	homocysteine
H2Q98_RS17670	COG0531	amino acid
H2Q98_RS17725	COG1595	DNA-templated transcription, initiation
H2Q98_RS17735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2Q98_RS17740	COG0477	Major facilitator Superfamily
H2Q98_RS17775	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS17810	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS17820	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS17915	COG1196	nuclear chromosome segregation
H2Q98_RS17915	COG0741	lytic transglycosylase activity
H2Q98_RS17915	COG0739	heme binding
H2Q98_RS17925	COG1598	PFAM Uncharacterised protein family UPF0150
H2Q98_RS18230	COG0405	Gamma-glutamyltransferase
H2Q98_RS18235	COG2814	Major facilitator Superfamily
H2Q98_RS18245	COG2050	protein possibly involved in aromatic compounds catabolism
H2Q98_RS18260	COG1090	epimerase
H2Q98_RS18280	COG0420	3'-5' exonuclease activity
H2Q98_RS18305	COG0735	belongs to the Fur family
H2Q98_RS18310	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H2Q98_RS18315	COG2914	Belongs to the UPF0125 (RnfH) family
H2Q98_RS18330	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS18335	COG0121	glutamine amidotransferase
H2Q98_RS18350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H2Q98_RS18360	COG0210	DNA helicase
H2Q98_RS18365	COG2885	chlorophyll binding
H2Q98_RS18370	COG0204	Acyl-transferase
H2Q98_RS18385	COG2894	cell division
H2Q98_RS18405	COG1280	lysine exporter protein (LysE YggA)
H2Q98_RS18410	COG1674	ftsk spoiiie
H2Q98_RS18415	COG0492	ferredoxin-NADP+ reductase activity
H2Q98_RS18420	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H2Q98_RS18430	COG0456	acetyltransferase
H2Q98_RS18445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H2Q98_RS18450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H2Q98_RS18460	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H2Q98_RS18475	COG1981	membrane
H2Q98_RS18485	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H2Q98_RS18485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H2Q98_RS18505	COG1012	belongs to the aldehyde dehydrogenase family
H2Q98_RS18510	COG4638	Rieske (2fe-2S)
H2Q98_RS18515	COG0657	acetylesterase activity
H2Q98_RS18525	COG0473	3-isopropylmalate dehydrogenase activity
H2Q98_RS18530	COG0583	DNA-binding transcription factor activity
H2Q98_RS18550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H2Q98_RS18585	COG0358	DNA primase activity
H2Q98_RS18600	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H2Q98_RS18630	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H2Q98_RS18660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H2Q98_RS18670	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H2Q98_RS18670	COG0352	thiamine-phosphate diphosphorylase activity
H2Q98_RS18670	COG0351	phosphomethylpyrimidine kinase
H2Q98_RS18675	COG1652	LysM domain
H2Q98_RS18700	COG1399	metal-binding, possibly nucleic acid-binding protein
H2Q98_RS18705	COG3101	peptidyl-lysine hydroxylation
H2Q98_RS18710	COG0009	L-threonylcarbamoyladenylate synthase
H2Q98_RS18715	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H2Q98_RS18720	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H2Q98_RS18735	COG4106	trans-aconitate 2-methyltransferase activity
H2Q98_RS18750	COG2226	methyltransferase
H2Q98_RS18750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2Q98_RS18750	COG0596	Alpha beta hydrolase
H2Q98_RS18755	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS18765	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H2Q98_RS18770	COG2223	nitrite transmembrane transporter activity
H2Q98_RS18795	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS18810	COG3328	transposase activity
H2Q98_RS18830	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS18860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H2Q98_RS18875	COG1196	nuclear chromosome segregation
H2Q98_RS18885	COG0730	response to heat
H2Q98_RS18900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H2Q98_RS18910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H2Q98_RS18955	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H2Q98_RS18960	COG0489	protein tyrosine kinase activity
H2Q98_RS18970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2Q98_RS18970	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2Q98_RS19005	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H2Q98_RS19010	COG2081	HI0933 family
H2Q98_RS19020	COG0668	transmembrane transport
H2Q98_RS19040	COG0583	DNA-binding transcription factor activity
H2Q98_RS19060	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2Q98_RS19065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H2Q98_RS19095	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H2Q98_RS19120	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS19125	COG2199	diguanylate cyclase activity
H2Q98_RS19140	COG0745	RESPONSE REGULATOR receiver
H2Q98_RS19155	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H2Q98_RS19180	COG2826	transposase and inactivated derivatives, IS30 family
H2Q98_RS19225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2Q98_RS19240	COG0583	DNA-binding transcription factor activity
H2Q98_RS19290	COG0583	DNA-binding transcription factor activity
H2Q98_RS19305	COG0583	DNA-binding transcription factor activity
H2Q98_RS19310	COG1053	succinate dehydrogenase
H2Q98_RS19325	COG1309	transcriptional regulator
H2Q98_RS19335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H2Q98_RS19340	COG2814	Major facilitator Superfamily
H2Q98_RS19345	COG1960	acyl-CoA dehydrogenase activity
H2Q98_RS19350	COG0583	DNA-binding transcription factor activity
H2Q98_RS19355	COG1063	alcohol dehydrogenase
H2Q98_RS19365	COG3328	transposase activity
H2Q98_RS19395	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H2Q98_RS19400	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H2Q98_RS19405	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H2Q98_RS19425	COG2132	Multicopper oxidase
H2Q98_RS19435	COG0561	phosphatase activity
H2Q98_RS19440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H2Q98_RS19465	COG1214	PFAM Peptidase M22, glycoprotease
H2Q98_RS19525	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H2Q98_RS19530	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H2Q98_RS19535	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine