locus-tag	class	description
H1I70_RS00010	COG0592	DNA-directed DNA polymerase activity
H1I70_RS00020	COG0187	DNA topoisomerase II activity
H1I70_RS00030	COG0586	Pfam SNARE associated Golgi protein
H1I70_RS00035	COG0488	(ABC) transporter
H1I70_RS00060	COG0596	Alpha beta hydrolase
H1I70_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H1I70_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H1I70_RS00110	COG0733	neurotransmitter:sodium symporter activity
H1I70_RS00150	COG2233	PERMEase
H1I70_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I70_RS00200	COG2814	Major facilitator Superfamily
H1I70_RS00205	COG0656	L-ascorbic acid biosynthetic process
H1I70_RS00210	COG0583	DNA-binding transcription factor activity
H1I70_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I70_RS00230	COG1064	alcohol dehydrogenase
H1I70_RS00235	COG2818	Glycosylase
H1I70_RS00250	COG1194	a g-specific adenine glycosylase
H1I70_RS00270	COG2983	Belongs to the UPF0260 family
H1I70_RS00275	COG2133	pyrroloquinoline quinone binding
H1I70_RS00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H1I70_RS00285	COG2116	formate transmembrane transporter activity
H1I70_RS00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I70_RS00310	COG1335	isochorismatase
H1I70_RS00315	COG0385	Bile acid
H1I70_RS00320	COG0534	Mate efflux family protein
H1I70_RS00325	COG1683	Conserved Protein
H1I70_RS00345	COG0625	glutathione transferase activity
H1I70_RS00355	COG1113	amino acid transport
H1I70_RS00365	COG0523	cobalamin synthesis protein
H1I70_RS00375	COG2188	Transcriptional regulator
H1I70_RS00405	COG0010	Belongs to the arginase family
H1I70_RS00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H1I70_RS00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H1I70_RS00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H1I70_RS00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H1I70_RS00540	COG0534	Mate efflux family protein
H1I70_RS00545	COG0436	Aminotransferase
H1I70_RS00550	COG2733	membrane
H1I70_RS00565	COG2918	glutathione biosynthetic process
H1I70_RS00580	COG1388	LysM domain
H1I70_RS00580	COG0791	NLP P60 protein
H1I70_RS00595	COG3150	esterase
H1I70_RS00605	COG1028	Short-chain dehydrogenase reductase Sdr
H1I70_RS00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H1I70_RS00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I70_RS00630	COG2233	PERMEase
H1I70_RS00635	COG2351	hydroxyisourate hydrolase activity
H1I70_RS00670	COG3706	GGDEF domain
H1I70_RS00685	COG1393	Belongs to the ArsC family
H1I70_RS00690	COG0708	Exodeoxyribonuclease III
H1I70_RS00710	COG0189	ligase activity
H1I70_RS00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H1I70_RS00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H1I70_RS00755	COG4942	peptidase
H1I70_RS00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1I70_RS00775	COG2119	membrane
H1I70_RS00780	COG4774	siderophore transport
H1I70_RS00785	COG0426	domain, Protein
H1I70_RS00785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I70_RS00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H1I70_RS00830	COG1902	pentaerythritol trinitrate reductase activity
H1I70_RS00835	COG1519	Transferase
H1I70_RS00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H1I70_RS00845	COG0668	transmembrane transport
H1I70_RS00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1I70_RS00860	COG1335	isochorismatase
H1I70_RS00865	COG1522	sequence-specific DNA binding
H1I70_RS00870	COG3328	transposase activity
H1I70_RS00895	COG2198	Histidine kinase
H1I70_RS00895	COG2205	protein histidine kinase activity
H1I70_RS00895	COG0784	Response regulator, receiver
H1I70_RS00900	COG3162	membrane
H1I70_RS00905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H1I70_RS00915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I70_RS00935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H1I70_RS00940	COG1309	transcriptional regulator
H1I70_RS00965	COG0351	phosphomethylpyrimidine kinase
H1I70_RS00965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H1I70_RS00965	COG0352	thiamine-phosphate diphosphorylase activity
H1I70_RS00975	COG2814	Major facilitator Superfamily
H1I70_RS00990	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H1I70_RS01000	COG1113	amino acid transport
H1I70_RS01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1I70_RS01015	COG1012	belongs to the aldehyde dehydrogenase family
H1I70_RS01025	COG1335	isochorismatase
H1I70_RS01055	COG2814	Major facilitator Superfamily
H1I70_RS01060	COG0583	DNA-binding transcription factor activity
H1I70_RS01080	COG0667	Aldo Keto reductase
H1I70_RS01115	COG1733	regulation of RNA biosynthetic process
H1I70_RS01120	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I70_RS01190	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H1I70_RS01205	COG2329	Antibiotic biosynthesis monooxygenase
H1I70_RS01235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H1I70_RS01265	COG0427	acetyl-CoA hydrolase
H1I70_RS01290	COG0659	secondary active sulfate transmembrane transporter activity
H1I70_RS01295	COG4221	oxidoreductase activity
H1I70_RS01300	COG2873	o-acetylhomoserine
H1I70_RS01305	COG0488	(ABC) transporter
H1I70_RS01390	COG0833	amino acid
H1I70_RS01435	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H1I70_RS01440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H1I70_RS01455	COG2226	methyltransferase
H1I70_RS01505	COG0070	glutamate synthase
H1I70_RS01505	COG0067	glutamate synthase
H1I70_RS01505	COG0069	glutamate synthase activity
H1I70_RS01510	COG0493	'glutamate synthase
H1I70_RS01520	COG1704	LemA family
H1I70_RS01525	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H1I70_RS01545	COG3307	-O-antigen
H1I70_RS01570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H1I70_RS01585	COG0194	GDP metabolic process
H1I70_RS01635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H1I70_RS01655	COG5380	lipid catabolic process
H1I70_RS01660	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H1I70_RS01685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H1I70_RS01690	COG0277	FAD linked oxidase domain protein
H1I70_RS01700	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H1I70_RS01705	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I70_RS01720	COG1289	transmembrane transporter activity
H1I70_RS01730	COG0628	permease
H1I70_RS01735	COG1192	Involved in chromosome partitioning
H1I70_RS01765	COG0833	amino acid
H1I70_RS01770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H1I70_RS01775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H1I70_RS01785	COG1012	belongs to the aldehyde dehydrogenase family
H1I70_RS01825	COG0583	DNA-binding transcription factor activity
H1I70_RS01870	COG0517	IMP dehydrogenase activity
H1I70_RS01875	COG1983	PspC domain protein
H1I70_RS01885	COG1960	acyl-CoA dehydrogenase activity
H1I70_RS01900	COG0408	coproporphyrinogen oxidase activity
H1I70_RS01920	COG0513	Belongs to the DEAD box helicase family
H1I70_RS01930	COG1127	ABC transporter
H1I70_RS01935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H1I70_RS01945	COG2854	intermembrane phospholipid transfer
H1I70_RS01955	COG0598	Magnesium transport protein CorA
H1I70_RS01965	COG0494	nUDIX hydrolase
H1I70_RS01970	COG1040	competence protein
H1I70_RS01975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H1I70_RS01995	COG1946	Acyl-CoA thioesterase
H1I70_RS02000	COG1301	dicarboxylic acid transport
H1I70_RS02015	COG1959	2 iron, 2 sulfur cluster binding
H1I70_RS02020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I70_RS02020	COG1017	nitric oxide dioxygenase activity
H1I70_RS02025	COG0433	COG0433 Predicted ATPase
H1I70_RS02030	COG0626	cystathionine gamma-synthase activity
H1I70_RS02185	COG1960	acyl-CoA dehydrogenase activity
H1I70_RS02190	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H1I70_RS02220	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H1I70_RS02225	COG0339	signal peptide processing
H1I70_RS02230	COG0557	exoribonuclease II activity
H1I70_RS02275	COG0179	Fumarylacetoacetate (FAA) hydrolase
H1I70_RS02280	COG2169	Transcriptional regulator
H1I70_RS02285	COG0697	spore germination
H1I70_RS02290	COG1295	ribonuclease BN
H1I70_RS02325	COG1702	phosphate starvation-inducible protein PhoH
H1I70_RS02335	COG0741	lytic transglycosylase activity
H1I70_RS02335	COG1196	nuclear chromosome segregation
H1I70_RS02335	COG0739	heme binding
H1I70_RS02365	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H1I70_RS02370	COG1183	phosphatidylcholine synthase activity
H1I70_RS02415	COG1960	acyl-CoA dehydrogenase activity
H1I70_RS02420	COG1309	transcriptional regulator
H1I70_RS02435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H1I70_RS02440	COG1960	acyl-CoA dehydrogenase activity
H1I70_RS02460	COG2969	positive regulation of protein catabolic process
H1I70_RS02470	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H1I70_RS02485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H1I70_RS02490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H1I70_RS02510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H1I70_RS02520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1I70_RS02525	COG1408	metallophosphoesterase
H1I70_RS02535	COG2199	diguanylate cyclase activity
H1I70_RS02595	COG1607	acyl-coa hydrolase
H1I70_RS02625	COG2350	Protein conserved in bacteria
H1I70_RS02635	COG0613	PHP domain protein
H1I70_RS02640	COG3781	membrane
H1I70_RS02650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H1I70_RS02655	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H1I70_RS02665	COG1862	Preprotein translocase
H1I70_RS02695	COG2205	protein histidine kinase activity
H1I70_RS02700	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H1I70_RS02720	COG0726	polysaccharide deacetylase
H1I70_RS02725	COG0463	Glycosyl transferase, family 2
H1I70_RS02730	COG0438	transferase activity, transferring glycosyl groups
H1I70_RS02795	COG0625	glutathione transferase activity
H1I70_RS02800	COG0583	DNA-binding transcription factor activity
H1I70_RS02805	COG1960	acyl-CoA dehydrogenase activity
H1I70_RS02810	COG1960	acyl-CoA dehydrogenase activity
H1I70_RS02820	COG2205	protein histidine kinase activity
H1I70_RS02825	COG0745	RESPONSE REGULATOR receiver
H1I70_RS02830	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H1I70_RS02850	COG2096	Adenosyltransferase
H1I70_RS02900	COG0285	dihydrofolate synthase activity
H1I70_RS02920	COG0450	alkyl hydroperoxide reductase
H1I70_RS02935	COG0477	Major facilitator Superfamily
H1I70_RS02940	COG1272	protein, Hemolysin III
H1I70_RS02970	COG0183	Belongs to the thiolase family
H1I70_RS02975	COG2207	Transcriptional regulator
H1I70_RS02995	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I70_RS03015	COG0183	Belongs to the thiolase family
H1I70_RS03025	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H1I70_RS03025	COG2885	chlorophyll binding
H1I70_RS03035	COG1690	Belongs to the RtcB family
H1I70_RS03040	COG0833	amino acid
H1I70_RS03050	COG2233	PERMEase
H1I70_RS03055	COG1217	gtp-binding protein TYPA
H1I70_RS03080	COG2094	Belongs to the DNA glycosylase MPG family
H1I70_RS03085	COG4772	TonB-dependent receptor
H1I70_RS03100	COG1902	pentaerythritol trinitrate reductase activity
H1I70_RS03115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1I70_RS03120	COG0354	folic acid binding
H1I70_RS03130	COG3189	MarR family transcriptional regulator
H1I70_RS03135	COG2824	Alkylphosphonate utilization operon protein PhnA
H1I70_RS03140	COG3422	double-strand break repair
H1I70_RS03180	COG0840	transmembrane signaling receptor activity
H1I70_RS03200	COG5510	response to toxic substance
H1I70_RS03210	COG2832	Protein of unknown function (DUF454)
H1I70_RS03215	COG1376	ErfK ybiS ycfS ynhG family protein
H1I70_RS03255	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H1I70_RS03265	COG1289	transmembrane transporter activity
H1I70_RS03270	COG2814	Major facilitator Superfamily
H1I70_RS03290	COG1115	amino acid carrier protein
H1I70_RS03295	COG1752	Esterase of the alpha-beta hydrolase superfamily
H1I70_RS03300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H1I70_RS03305	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H1I70_RS03335	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H1I70_RS03345	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H1I70_RS03350	COG1077	Cell shape determining protein MreB Mrl
H1I70_RS03355	COG1792	Involved in formation and maintenance of cell shape
H1I70_RS03360	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H1I70_RS03365	COG0424	maF-like protein
H1I70_RS03370	COG1530	ribonuclease E activity
H1I70_RS03380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I70_RS03390	COG0560	Phosphoserine phosphatase
H1I70_RS03400	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I70_RS03425	COG2207	Transcriptional regulator
H1I70_RS03445	COG1113	amino acid transport
H1I70_RS03450	COG2828	Protein conserved in bacteria
H1I70_RS03455	COG0142	geranyltranstransferase activity
H1I70_RS03460	COG2315	Protein conserved in bacteria
H1I70_RS03475	COG1752	Esterase of the alpha-beta hydrolase superfamily
H1I70_RS03495	COG2194	sulfuric ester hydrolase activity
H1I70_RS03500	COG0745	RESPONSE REGULATOR receiver
H1I70_RS03505	COG0642	Histidine kinase
H1I70_RS03515	COG0004	ammonium transporteR
H1I70_RS03520	COG0583	DNA-binding transcription factor activity
H1I70_RS03540	COG0525	valine-tRNA ligase activity
H1I70_RS03550	COG1028	Short-chain dehydrogenase reductase Sdr
H1I70_RS03560	COG0393	Putative heavy-metal-binding
H1I70_RS03565	COG0393	Putative heavy-metal-binding
H1I70_RS03570	COG1538	Outer membrane efflux protein
H1I70_RS03580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I70_RS03585	COG0671	phosphoesterase, PA-phosphatase related
H1I70_RS03615	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H1I70_RS03630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H1I70_RS03630	COG1648	precorrin-2 dehydrogenase activity
H1I70_RS03635	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H1I70_RS03640	COG1733	regulation of RNA biosynthetic process
H1I70_RS03650	COG0531	amino acid
H1I70_RS03665	COG0321	lipoyl(octanoyl) transferase activity
H1I70_RS03670	COG2921	Belongs to the UPF0250 family
H1I70_RS03710	COG2009	succinate dehydrogenase
H1I70_RS03715	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H1I70_RS03720	COG1053	succinate dehydrogenase
H1I70_RS03725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H1I70_RS03750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1I70_RS03770	COG2354	Protein conserved in bacteria
H1I70_RS03775	COG2321	neutral zinc metallopeptidase
H1I70_RS03810	COG2843	Capsule synthesis protein
H1I70_RS03825	COG0589	response to stress
H1I70_RS03845	COG0505	Belongs to the CarA family
H1I70_RS03870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1I70_RS03875	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H1I70_RS03925	COG0477	Major facilitator Superfamily
H1I70_RS03930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H1I70_RS03945	COG1597	lipid kinase activity
H1I70_RS03950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H1I70_RS03980	COG0584	glycerophosphoryl diester phosphodiesterase
H1I70_RS04000	COG0741	lytic transglycosylase activity
H1I70_RS04020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H1I70_RS04035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I70_RS04060	COG0778	Nitroreductase
H1I70_RS04075	COG1929	Belongs to the glycerate kinase type-1 family
H1I70_RS04080	COG0243	molybdopterin cofactor binding
H1I70_RS04085	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H1I70_RS04090	COG3339	Conserved Protein
H1I70_RS04100	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H1I70_RS04115	COG1113	amino acid transport
H1I70_RS04125	COG0019	diaminopimelate decarboxylase activity
H1I70_RS04135	COG1280	lysine exporter protein (LysE YggA)
H1I70_RS04140	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H1I70_RS04170	COG0463	Glycosyl transferase, family 2
H1I70_RS04190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I70_RS04225	COG4591	ABC-type transport system involved in lipoprotein release permease component
H1I70_RS04230	COG1136	(ABC) transporter
H1I70_RS04235	COG0658	competence protein
H1I70_RS04235	COG2333	competence protein COMEC
H1I70_RS04245	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H1I70_RS04245	COG0616	signal peptide processing
H1I70_RS04250	COG0596	Alpha beta hydrolase
H1I70_RS04255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H1I70_RS04265	COG0628	permease
H1I70_RS04300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1I70_RS04320	COG0823	Involved in the tonB-independent uptake of proteins
H1I70_RS04340	COG0824	Thioesterase
H1I70_RS04345	COG1473	amidohydrolase
H1I70_RS04365	COG0047	phosphoribosylformylglycinamidine synthase activity
H1I70_RS04365	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H1I70_RS04370	COG2814	Major facilitator Superfamily
H1I70_RS04380	COG1024	Enoyl-CoA hydratase
H1I70_RS04385	COG1056	cytidyltransferase-related domain
H1I70_RS04385	COG1051	belongs to the nudix hydrolase family
H1I70_RS04395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H1I70_RS04410	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H1I70_RS04425	COG4625	pathogenesis
H1I70_RS04430	COG0583	DNA-binding transcription factor activity
H1I70_RS04435	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H1I70_RS04440	COG4208	sulfate ABC transporter
H1I70_RS04445	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H1I70_RS04455	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H1I70_RS04460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H1I70_RS04465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H1I70_RS04485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1I70_RS04500	COG0681	Belongs to the peptidase S26 family
H1I70_RS04515	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H1I70_RS04525	COG1381	Involved in DNA repair and RecF pathway recombination
H1I70_RS04530	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H1I70_RS04540	COG4221	oxidoreductase activity
H1I70_RS04570	COG0436	Aminotransferase
H1I70_RS04590	COG0556	nucleotide-excision repair
H1I70_RS04645	COG2070	2-Nitropropane dioxygenase
H1I70_RS04675	COG1215	transferase activity, transferring glycosyl groups
H1I70_RS04690	COG0415	Belongs to the DNA photolyase family
H1I70_RS04700	COG1252	NADH dehydrogenase
H1I70_RS04705	COG1686	Belongs to the peptidase S11 family
H1I70_RS04720	COG1187	pseudouridine synthase activity
H1I70_RS04745	COG0477	Major facilitator Superfamily
H1I70_RS04750	COG0583	DNA-binding transcription factor activity
H1I70_RS04755	COG1823	symporter activity
H1I70_RS04765	COG0612	Peptidase, M16
H1I70_RS04790	COG0352	thiamine-phosphate diphosphorylase activity
H1I70_RS04825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I70_RS04840	COG1309	transcriptional regulator
H1I70_RS04850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1I70_RS04855	COG0076	glutamate decarboxylase activity
H1I70_RS04865	COG1522	sequence-specific DNA binding
H1I70_RS04870	COG3961	Belongs to the TPP enzyme family
H1I70_RS04875	COG1113	amino acid transport
H1I70_RS04880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H1I70_RS04885	COG0573	inorganic phosphate transmembrane transporter activity
H1I70_RS04895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H1I70_RS04900	COG0616	signal peptide processing
H1I70_RS04935	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H1I70_RS04940	COG1686	Belongs to the peptidase S11 family
H1I70_RS04965	COG0583	DNA-binding transcription factor activity
H1I70_RS04970	COG1067	ATP-dependent peptidase activity
H1I70_RS05015	COG1966	Carbon starvation protein
H1I70_RS05020	COG2879	small protein
H1I70_RS05050	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H1I70_RS05050	COG2508	Transcriptional regulator
H1I70_RS05070	COG1113	amino acid transport
H1I70_RS05075	COG0583	DNA-binding transcription factor activity
H1I70_RS05080	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I70_RS05105	COG1012	belongs to the aldehyde dehydrogenase family
H1I70_RS05110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I70_RS05115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1I70_RS05115	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H1I70_RS05150	COG2814	Major facilitator Superfamily
H1I70_RS05155	COG4948	Mandelate Racemase Muconate Lactonizing
H1I70_RS05165	COG1309	transcriptional regulator
H1I70_RS05185	COG1741	Belongs to the pirin family
H1I70_RS05195	COG2964	Protein conserved in bacteria
H1I70_RS05210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I70_RS05215	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1I70_RS05220	COG4605	iron ion homeostasis
H1I70_RS05225	COG4604	ABC transporter, ATP-binding protein
H1I70_RS05230	COG4607	ABC-type enterochelin transport system periplasmic component
H1I70_RS05235	COG4774	siderophore transport
H1I70_RS05245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I70_RS05250	COG1021	2,3-dihydroxybenzoate-AMP ligase
H1I70_RS05255	COG1535	isochorismatase
H1I70_RS05255	COG3433	isochorismatase activity
H1I70_RS05270	COG1132	(ABC) transporter
H1I70_RS05275	COG1132	(ABC) transporter
H1I70_RS05280	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H1I70_RS05290	COG1169	isochorismate synthase
H1I70_RS05305	COG3739	integral membrane protein
H1I70_RS05330	COG0302	gtp cyclohydrolase
H1I70_RS05340	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1I70_RS05370	COG0308	aminopeptidase N
H1I70_RS05375	COG0512	Glutamine amidotransferase of anthranilate synthase
H1I70_RS05390	COG0174	glutamine synthetase
H1I70_RS05400	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H1I70_RS05435	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H1I70_RS05440	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H1I70_RS05445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1I70_RS05465	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H1I70_RS05470	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H1I70_RS05475	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H1I70_RS05490	COG1960	acyl-CoA dehydrogenase activity
H1I70_RS05495	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H1I70_RS05500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1I70_RS05510	COG2223	nitrite transmembrane transporter activity
H1I70_RS05520	COG0024	Methionine aminopeptidase
H1I70_RS05525	COG0052	Belongs to the universal ribosomal protein uS2 family
H1I70_RS05540	COG2207	Transcriptional regulator
H1I70_RS05565	COG2951	lytic endotransglycosylase activity
H1I70_RS05570	COG0772	Belongs to the SEDS family
H1I70_RS05585	COG0842	Transport permease protein
H1I70_RS05590	COG1131	(ABC) transporter
H1I70_RS05635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I70_RS05650	COG4215	(ABC) transporter
H1I70_RS05655	COG4160	amino acid transport
H1I70_RS05660	COG4598	ABC transporter
H1I70_RS05670	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H1I70_RS05675	COG0826	peptidase U32
H1I70_RS05680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I70_RS05695	COG1720	tRNA m6t6A37 methyltransferase activity
H1I70_RS05705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H1I70_RS05720	COG0642	Histidine kinase
H1I70_RS05730	COG0494	nUDIX hydrolase
H1I70_RS05740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H1I70_RS05745	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H1I70_RS05750	COG3139	Protein of unknown function (DUF1315)
H1I70_RS05755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H1I70_RS05760	COG1301	dicarboxylic acid transport
H1I70_RS05765	COG1960	acyl-CoA dehydrogenase activity
H1I70_RS05770	COG2819	hydrolase of the alpha beta superfamily
H1I70_RS05780	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H1I70_RS05790	COG2195	Cleaves the N-terminal amino acid of tripeptides
H1I70_RS05795	COG1234	tRNA 3'-trailer cleavage
H1I70_RS05825	COG2363	Small membrane protein
H1I70_RS05845	COG0513	Belongs to the DEAD box helicase family
H1I70_RS05855	COG0778	Nitroreductase
H1I70_RS06200	COG1286	toxin biosynthetic process
H1I70_RS06225	COG4783	chaperone-mediated protein folding
H1I70_RS06230	COG1610	YqeY-like protein
H1I70_RS06330	COG3111	PFAM Bacterial OB fold (BOF) protein
H1I70_RS06355	COG3243	poly(R)-hydroxyalkanoic acid synthase
H1I70_RS06360	COG0786	glutamate:sodium symporter activity
H1I70_RS06370	COG2186	Transcriptional regulator
H1I70_RS06420	COG0477	Major facilitator Superfamily
H1I70_RS06525	COG0482	sulfurtransferase activity
H1I70_RS06540	COG0488	(ABC) transporter
H1I70_RS06545	COG3173	Aminoglycoside phosphotransferase
H1I70_RS06555	COG2433	Pfam Transposase IS66
H1I70_RS06585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I70_RS06590	COG1024	Enoyl-CoA hydratase
H1I70_RS06595	COG1024	Enoyl-CoA hydratase
H1I70_RS06600	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1I70_RS06605	COG0183	Belongs to the thiolase family
H1I70_RS06610	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H1I70_RS06615	COG3327	negative regulation of DNA-templated transcription, initiation
H1I70_RS06625	COG2050	protein possibly involved in aromatic compounds catabolism
H1I70_RS06660	COG0753	catalase activity
H1I70_RS06665	COG3038	cytochrome b561
H1I70_RS06685	COG2267	carboxylic ester hydrolase activity
H1I70_RS06690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I70_RS06695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1I70_RS06700	COG1012	belongs to the aldehyde dehydrogenase family
H1I70_RS06710	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H1I70_RS06720	COG1012	belongs to the aldehyde dehydrogenase family
H1I70_RS06725	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H1I70_RS06730	COG0583	DNA-binding transcription factor activity
H1I70_RS06740	COG1414	Transcriptional regulator
H1I70_RS06745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I70_RS06755	COG1840	ABC-type Fe3 transport system, periplasmic component
H1I70_RS06760	COG3842	ATPase activity
H1I70_RS06775	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H1I70_RS06780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1I70_RS06785	COG2814	Major facilitator Superfamily
H1I70_RS06790	COG1960	acyl-CoA dehydrogenase activity
H1I70_RS06805	COG1024	Enoyl-CoA hydratase
H1I70_RS06815	COG2814	Major facilitator Superfamily
H1I70_RS06825	COG0183	Belongs to the thiolase family
H1I70_RS06830	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1I70_RS06835	COG1028	Short-chain dehydrogenase reductase Sdr
H1I70_RS06840	COG1024	Enoyl-CoA hydratase
H1I70_RS06845	COG1960	acyl-CoA dehydrogenase activity
H1I70_RS06850	COG2814	Major facilitator Superfamily
H1I70_RS06855	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H1I70_RS06860	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I70_RS06870	COG2814	Major facilitator Superfamily
H1I70_RS06880	COG1960	acyl-CoA dehydrogenase activity
H1I70_RS06895	COG0583	DNA-binding transcription factor activity
H1I70_RS06905	COG4770	biotin carboxylase activity
H1I70_RS06910	COG1024	Enoyl-CoA hydratase
H1I70_RS06915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H1I70_RS06920	COG1960	acyl-CoA dehydrogenase activity
H1I70_RS06925	COG1309	transcriptional regulator
H1I70_RS06930	COG0318	PFAM AMP-dependent synthetase and ligase
H1I70_RS06950	COG0583	DNA-binding transcription factor activity
H1I70_RS07000	COG1028	Short-chain dehydrogenase reductase Sdr
H1I70_RS07020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H1I70_RS07040	COG2205	protein histidine kinase activity
H1I70_RS07040	COG0784	Response regulator, receiver
H1I70_RS07060	COG0765	amino acid transport
H1I70_RS07065	COG0765	amino acid transport
H1I70_RS07070	COG1126	abc transporter atp-binding protein
H1I70_RS07075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1I70_RS07080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1I70_RS07095	COG1280	lysine exporter protein (LysE YggA)
H1I70_RS07105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H1I70_RS07110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1I70_RS07115	COG1045	serine acetyltransferase
H1I70_RS07130	COG0583	DNA-binding transcription factor activity
H1I70_RS07135	COG0625	glutathione transferase activity
H1I70_RS07140	COG0625	glutathione transferase activity
H1I70_RS07145	COG0583	DNA-binding transcription factor activity
H1I70_RS07155	COG1346	cytolysis
H1I70_RS07175	COG2814	Major facilitator Superfamily
H1I70_RS07185	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H1I70_RS07190	COG3052	prosthetic group binding
H1I70_RS07210	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H1I70_RS07230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I70_RS07240	COG1294	oxidase, subunit
H1I70_RS07245	COG1271	oxidase subunit
H1I70_RS07265	COG0477	Major facilitator Superfamily
H1I70_RS07275	COG4521	taurine ABC transporter
H1I70_RS07280	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H1I70_RS07285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I70_RS07290	COG2175	clavaminate synthase activity
H1I70_RS07300	COG1953	Uracil, thiamine, allantoin
H1I70_RS07310	COG0583	DNA-binding transcription factor activity
H1I70_RS07320	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H1I70_RS07335	COG0640	Transcriptional regulator
H1I70_RS07340	COG0798	PFAM Bile acid sodium symporter
H1I70_RS07345	COG0583	DNA-binding transcription factor activity
H1I70_RS07360	COG3634	alkyl hydroperoxide reductase activity
H1I70_RS07400	COG0436	Aminotransferase
H1I70_RS07410	COG0386	Belongs to the glutathione peroxidase family
H1I70_RS07450	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H1I70_RS07475	COG0012	GTP binding
H1I70_RS07480	COG2011	ABC-type metal ion transport system permease component
H1I70_RS07485	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H1I70_RS07505	COG1464	Belongs to the NlpA lipoprotein family
H1I70_RS07535	COG0765	amino acid transport
H1I70_RS07540	COG0765	amino acid transport
H1I70_RS07545	COG1126	abc transporter atp-binding protein
H1I70_RS07560	COG1522	sequence-specific DNA binding
H1I70_RS07575	COG1309	transcriptional regulator
H1I70_RS07595	COG0583	DNA-binding transcription factor activity
H1I70_RS07605	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H1I70_RS07615	COG0697	spore germination
H1I70_RS07640	COG3121	Chaperone
H1I70_RS07645	COG3539	Fimbrial protein
H1I70_RS07670	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H1I70_RS07670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H1I70_RS07715	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H1I70_RS07725	COG2353	YceI-like domain
H1I70_RS07735	COG3698	Phosphodiester glycosidase
H1I70_RS07750	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H1I70_RS07755	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H1I70_RS07755	COG0506	proline dehydrogenase activity
H1I70_RS07755	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H1I70_RS07765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H1I70_RS07770	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H1I70_RS07790	COG1132	(ABC) transporter
H1I70_RS07795	COG3122	Protein conserved in bacteria
H1I70_RS07800	COG3619	membrane
H1I70_RS07810	COG0640	Transcriptional regulator
H1I70_RS07820	COG2850	peptidyl-arginine hydroxylation
H1I70_RS07825	COG0424	maF-like protein
H1I70_RS07845	COG0191	fructose-bisphosphate aldolase activity
H1I70_RS07850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H1I70_RS07865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H1I70_RS07875	COG1192	Involved in chromosome partitioning
H1I70_RS07880	COG1475	DNA binding
H1I70_RS07885	COG0811	peptide transport
H1I70_RS07895	COG1132	(ABC) transporter
H1I70_RS07900	COG1663	tetraacyldisaccharide 4'-kinase activity
H1I70_RS07920	COG0084	hydrolase, TatD family'
H1I70_RS07985	COG0776	regulation of translation
H1I70_RS08015	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H1I70_RS08020	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H1I70_RS08070	COG0339	signal peptide processing
H1I70_RS08080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1I70_RS08115	COG0702	epimerase
H1I70_RS08120	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H1I70_RS08140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H1I70_RS08170	COG0316	Belongs to the HesB IscA family
H1I70_RS08175	COG0822	iron-sulfur transferase activity
H1I70_RS08200	COG0776	regulation of translation
H1I70_RS08205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H1I70_RS08210	COG2207	Transcriptional regulator
H1I70_RS08215	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1I70_RS08220	COG1960	acyl-CoA dehydrogenase activity
H1I70_RS08225	COG1960	acyl-CoA dehydrogenase activity
H1I70_RS08240	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H1I70_RS08260	COG4264	IucA IucC family
H1I70_RS08265	COG4264	IucA IucC family
H1I70_RS08305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1I70_RS08320	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H1I70_RS08340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H1I70_RS08345	COG0730	response to heat
H1I70_RS08365	COG4773	Receptor
H1I70_RS08370	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1I70_RS08385	COG1131	(ABC) transporter
H1I70_RS08390	COG0842	Transport permease protein
H1I70_RS08395	COG0842	Transport permease protein
H1I70_RS08450	COG2226	methyltransferase
H1I70_RS08475	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H1I70_RS08510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1I70_RS08520	COG0133	tryptophan synthase activity
H1I70_RS08535	COG3706	GGDEF domain
H1I70_RS08550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H1I70_RS08555	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H1I70_RS08560	COG0022	dehydrogenase e1 component
H1I70_RS08565	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1I70_RS08570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1I70_RS08580	COG1063	alcohol dehydrogenase
H1I70_RS08585	COG3781	membrane
H1I70_RS08595	COG3453	Protein conserved in bacteria
H1I70_RS08595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1I70_RS08605	COG0730	response to heat
H1I70_RS08620	COG2207	Transcriptional regulator
H1I70_RS08620	COG3708	Transcriptional regulator
H1I70_RS08625	COG1733	regulation of RNA biosynthetic process
H1I70_RS08630	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H1I70_RS08640	COG2188	Transcriptional regulator
H1I70_RS08655	COG4521	taurine ABC transporter
H1I70_RS08660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I70_RS08680	COG0477	Major facilitator Superfamily
H1I70_RS08690	COG1027	Aspartate ammonia-lyase
H1I70_RS08705	COG0583	DNA-binding transcription factor activity
H1I70_RS08710	COG0583	DNA-binding transcription factor activity
H1I70_RS08715	COG0183	Belongs to the thiolase family
H1I70_RS08720	COG2031	fatty acid transporter
H1I70_RS08725	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I70_RS08735	COG0583	DNA-binding transcription factor activity
H1I70_RS08745	COG2610	gluconate transmembrane transporter activity
H1I70_RS08750	COG1028	Short-chain dehydrogenase reductase Sdr
H1I70_RS08760	COG2207	Transcriptional regulator
H1I70_RS08775	COG1028	Short-chain dehydrogenase reductase Sdr
H1I70_RS08800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I70_RS08800	COG0543	2 iron, 2 sulfur cluster binding
H1I70_RS08805	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H1I70_RS08810	COG4638	Rieske (2fe-2S)
H1I70_RS08820	COG0725	ABC transporter, periplasmic molybdate-binding protein
H1I70_RS08825	COG4149	molybdate abc transporter
H1I70_RS08830	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H1I70_RS08835	COG1028	Short-chain dehydrogenase reductase Sdr
H1I70_RS08840	COG1535	isochorismatase
H1I70_RS08840	COG3433	isochorismatase activity
H1I70_RS08900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1I70_RS08915	COG0753	catalase activity
H1I70_RS08925	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H1I70_RS08955	COG3539	Fimbrial protein
H1I70_RS08975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1I70_RS08995	COG2072	flavoprotein involved in K transport
H1I70_RS09005	COG1538	Outer membrane efflux protein
H1I70_RS09010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1I70_RS09015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I70_RS09020	COG0745	RESPONSE REGULATOR receiver
H1I70_RS09025	COG2205	protein histidine kinase activity
H1I70_RS09035	COG2207	Transcriptional regulator
H1I70_RS09050	COG1028	Short-chain dehydrogenase reductase Sdr
H1I70_RS09100	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H1I70_RS09215	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H1I70_RS09235	COG1120	ATPase activity
H1I70_RS09240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1I70_RS09250	COG1064	alcohol dehydrogenase
H1I70_RS09265	COG2207	Transcriptional regulator
H1I70_RS09270	COG2084	Dehydrogenase
H1I70_RS09280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1I70_RS09285	COG0583	DNA-binding transcription factor activity
H1I70_RS09295	COG0129	dihydroxy-acid dehydratase activity
H1I70_RS09300	COG1012	belongs to the aldehyde dehydrogenase family
H1I70_RS09315	COG1566	PFAM secretion protein HlyD family protein
H1I70_RS09335	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H1I70_RS09365	COG0583	DNA-binding transcription factor activity
H1I70_RS09380	COG2188	Transcriptional regulator
H1I70_RS09410	COG3210	domain, Protein
H1I70_RS09415	COG2831	hemolysin activation secretion protein
H1I70_RS09425	COG1473	amidohydrolase
H1I70_RS09435	COG0475	glutathione-regulated potassium exporter activity
H1I70_RS09435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1I70_RS09445	COG0583	DNA-binding transcription factor activity
H1I70_RS09450	COG1335	isochorismatase
H1I70_RS09460	COG1309	transcriptional regulator
H1I70_RS09490	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H1I70_RS09500	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I70_RS09500	COG1902	pentaerythritol trinitrate reductase activity
H1I70_RS09505	COG1846	Transcriptional regulator
H1I70_RS09525	COG0753	catalase activity
H1I70_RS09540	COG1012	belongs to the aldehyde dehydrogenase family
H1I70_RS09565	COG3162	membrane
H1I70_RS09575	COG3829	transcription factor binding
H1I70_RS09580	COG1028	Short-chain dehydrogenase reductase Sdr
H1I70_RS09585	COG1960	acyl-CoA dehydrogenase activity
H1I70_RS09605	COG1012	belongs to the aldehyde dehydrogenase family
H1I70_RS09625	COG2186	Transcriptional regulator
H1I70_RS09635	COG0583	DNA-binding transcription factor activity
H1I70_RS09640	COG4948	Mandelate Racemase Muconate Lactonizing
H1I70_RS09645	COG4829	muconolactone delta-isomerase
H1I70_RS09655	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H1I70_RS09660	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I70_RS09665	COG0183	Belongs to the thiolase family
H1I70_RS09670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1I70_RS09680	COG1012	belongs to the aldehyde dehydrogenase family
H1I70_RS09690	COG3733	amine oxidase
H1I70_RS09700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I70_RS09710	COG1028	Short-chain dehydrogenase reductase Sdr
H1I70_RS09720	COG4638	Rieske (2fe-2S)
H1I70_RS09740	COG0154	amidase activity
H1I70_RS09750	COG2814	Major facilitator Superfamily
H1I70_RS09775	COG1960	acyl-CoA dehydrogenase activity
H1I70_RS09780	COG0583	DNA-binding transcription factor activity
H1I70_RS09785	COG1414	Transcriptional regulator
H1I70_RS09800	COG2391	methyltransferase activity
H1I70_RS09810	COG4993	Dehydrogenase
H1I70_RS09815	COG3659	wide pore channel activity
H1I70_RS09820	COG3420	alginic acid biosynthetic process
H1I70_RS09825	COG0710	3-dehydroquinate dehydratase activity
H1I70_RS09830	COG3485	protocatechuate 3,4-dioxygenase
H1I70_RS09835	COG3485	protocatechuate 3,4-dioxygenase
H1I70_RS09840	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H1I70_RS09845	COG2271	Major facilitator Superfamily
H1I70_RS09850	COG0596	Alpha beta hydrolase
H1I70_RS09855	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H1I70_RS09860	COG0183	Belongs to the thiolase family
H1I70_RS09865	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I70_RS09870	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H1I70_RS09880	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H1I70_RS09885	COG2323	membrane
H1I70_RS09930	COG1902	pentaerythritol trinitrate reductase activity
H1I70_RS09930	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I70_RS09955	COG0542	response to heat
H1I70_RS09960	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H1I70_RS09990	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H1I70_RS09995	COG0569	domain protein
H1I70_RS10000	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H1I70_RS10015	COG4774	siderophore transport
H1I70_RS10020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1I70_RS10030	COG1585	Membrane protein implicated in regulation of membrane protease activity
H1I70_RS10045	COG1294	oxidase, subunit
H1I70_RS10050	COG4890	Cyd operon protein YbgT
H1I70_RS10065	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H1I70_RS10075	COG0552	protein localization to endoplasmic reticulum
H1I70_RS10100	COG0516	GMP reductase activity
H1I70_RS10100	COG0517	IMP dehydrogenase activity
H1I70_RS10105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H1I70_RS10110	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H1I70_RS10120	COG0583	DNA-binding transcription factor activity
H1I70_RS10125	COG0024	Methionine aminopeptidase
H1I70_RS10155	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1I70_RS10155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H1I70_RS10160	COG1105	Belongs to the carbohydrate kinase PfkB family
H1I70_RS10165	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H1I70_RS10165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H1I70_RS10165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H1I70_RS10185	COG3300	MHYT domain
H1I70_RS10185	COG5001	Diguanylate cyclase
H1I70_RS10200	COG2135	peptidase activity
H1I70_RS10205	COG0659	secondary active sulfate transmembrane transporter activity
H1I70_RS10220	COG1113	amino acid transport
H1I70_RS10230	COG1522	sequence-specific DNA binding
H1I70_RS10255	COG1011	Hydrolase
H1I70_RS10260	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H1I70_RS10270	COG2137	regulation of response to DNA damage stimulus
H1I70_RS10285	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1I70_RS10320	COG0575	Belongs to the CDS family
H1I70_RS10325	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H1I70_RS10345	COG3852	Histidine kinase
H1I70_RS10350	COG2204	response regulator
H1I70_RS10415	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H1I70_RS10420	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H1I70_RS10440	COG0697	spore germination
H1I70_RS10445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I70_RS10455	COG0303	'Molybdopterin
H1I70_RS10460	COG0521	Mo-molybdopterin cofactor biosynthetic process
H1I70_RS10460	COG0315	cyclic pyranopterin monophosphate synthase activity
H1I70_RS10475	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H1I70_RS10480	COG0243	molybdopterin cofactor binding
H1I70_RS10490	COG0243	molybdopterin cofactor binding
H1I70_RS10495	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I70_RS10500	COG2146	nitrite reductase [NAD(P)H] activity
H1I70_RS10500	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I70_RS10510	COG0745	RESPONSE REGULATOR receiver
H1I70_RS10515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I70_RS10515	COG1116	anion transmembrane transporter activity
H1I70_RS10535	COG0511	ligase activity, forming carbon-carbon bonds
H1I70_RS10550	COG2814	Major facilitator Superfamily
H1I70_RS10640	COG1598	PFAM Uncharacterised protein family UPF0150
H1I70_RS10750	COG5410	chromosome segregation
H1I70_RS10930	COG0069	glutamate synthase activity
H1I70_RS10950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H1I70_RS10960	COG1454	alcohol dehydrogenase
H1I70_RS10965	COG0824	Thioesterase
H1I70_RS10975	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H1I70_RS10990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H1I70_RS10995	COG2030	dehydratase
H1I70_RS11005	COG0183	Belongs to the thiolase family
H1I70_RS11015	COG0583	DNA-binding transcription factor activity
H1I70_RS11020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H1I70_RS11030	COG1522	sequence-specific DNA binding
H1I70_RS11035	COG3135	benzoate transporter
H1I70_RS11045	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H1I70_RS11070	COG0589	response to stress
H1I70_RS11075	COG0488	(ABC) transporter
H1I70_RS11095	COG4773	Receptor
H1I70_RS11130	COG0668	transmembrane transport
H1I70_RS11140	COG1309	transcriptional regulator
H1I70_RS11155	COG1605	Chorismate mutase
H1I70_RS11165	COG4221	oxidoreductase activity
H1I70_RS11175	COG0308	aminopeptidase N
H1I70_RS11195	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H1I70_RS11205	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1I70_RS11210	COG1454	alcohol dehydrogenase
H1I70_RS11230	COG0531	amino acid
H1I70_RS11235	COG4303	Ethanolamine ammonia lyase large subunit
H1I70_RS11240	COG4302	ethanolamine ammonia-lyase activity
H1I70_RS11245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H1I70_RS11245	COG0519	Catalyzes the synthesis of GMP from XMP
H1I70_RS11250	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1I70_RS11260	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1I70_RS11275	COG0697	spore germination
H1I70_RS11280	COG1923	regulation of RNA biosynthetic process
H1I70_RS11290	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H1I70_RS11295	COG0802	atpase or kinase
H1I70_RS11315	COG1187	pseudouridine synthase activity
H1I70_RS11330	COG0583	DNA-binding transcription factor activity
H1I70_RS11345	COG2814	Major facilitator Superfamily
H1I70_RS11350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1I70_RS11375	COG0729	surface antigen
H1I70_RS11395	COG0174	glutamine synthetase
H1I70_RS11400	COG0745	RESPONSE REGULATOR receiver
H1I70_RS11405	COG2205	protein histidine kinase activity
H1I70_RS11415	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H1I70_RS11420	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H1I70_RS11445	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I70_RS11450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1I70_RS11455	COG1960	acyl-CoA dehydrogenase activity
H1I70_RS11470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I70_RS11475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I70_RS11495	COG0583	DNA-binding transcription factor activity
H1I70_RS11510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1I70_RS11520	COG3658	cytochrome
H1I70_RS11525	COG1215	transferase activity, transferring glycosyl groups
H1I70_RS11530	COG0726	polysaccharide deacetylase
H1I70_RS11530	COG1649	PFAM Uncharacterised BCR, COG1649
H1I70_RS11555	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H1I70_RS11560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H1I70_RS11570	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H1I70_RS11595	COG0305	Participates in initiation and elongation during chromosome replication
H1I70_RS11600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H1I70_RS11610	COG1305	Transglutaminase-like
H1I70_RS11620	COG2308	Evidence 4 Homologs of previously reported genes of
H1I70_RS11650	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H1I70_RS11655	COG0138	bifunctional purine biosynthesis protein purh
H1I70_RS11660	COG0151	Belongs to the GarS family
H1I70_RS11665	COG1464	Belongs to the NlpA lipoprotein family
H1I70_RS11670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H1I70_RS11675	COG2011	ABC-type metal ion transport system permease component
H1I70_RS11680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1I70_RS11690	COG1301	dicarboxylic acid transport
H1I70_RS11715	COG2151	metal-sulfur cluster biosynthetic enzyme
H1I70_RS11720	COG3396	Phenylacetate-CoA oxygenase
H1I70_RS11725	COG3460	Phenylacetate-CoA oxygenase
H1I70_RS11730	COG3396	Phenylacetate-CoA oxygenase
H1I70_RS11735	COG1012	belongs to the aldehyde dehydrogenase family
H1I70_RS11735	COG2030	dehydratase
H1I70_RS11740	COG1760	l-serine dehydratase
H1I70_RS11745	COG0531	amino acid
H1I70_RS11750	COG1012	belongs to the aldehyde dehydrogenase family
H1I70_RS11765	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I70_RS11775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1I70_RS11795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I70_RS11805	COG0789	Transcriptional regulator
H1I70_RS11820	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H1I70_RS11835	COG2807	transmembrane transport
H1I70_RS11840	COG0590	tRNA wobble adenosine to inosine editing
H1I70_RS11955	COG1116	anion transmembrane transporter activity
H1I70_RS11960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1I70_RS11970	COG0864	Transcriptional regulator
H1I70_RS11990	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I70_RS11995	COG0439	Biotin carboxylase
H1I70_RS12010	COG1063	alcohol dehydrogenase
H1I70_RS12020	COG1309	transcriptional regulator
H1I70_RS12040	COG0038	chloride channel
H1I70_RS12045	COG4770	biotin carboxylase activity
H1I70_RS12065	COG1914	H( )-stimulated, divalent metal cation uptake system
H1I70_RS12070	COG0583	DNA-binding transcription factor activity
H1I70_RS12120	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1I70_RS12140	COG2814	Major facilitator Superfamily
H1I70_RS12150	COG1560	Kdo2-lipid A biosynthetic process
H1I70_RS12160	COG5006	permease, DMT superfamily
H1I70_RS12165	COG1522	sequence-specific DNA binding
H1I70_RS12180	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H1I70_RS12190	COG4122	O-methyltransferase activity
H1I70_RS12220	COG1538	Outer membrane efflux protein
H1I70_RS12225	COG1137	ATPase activity
H1I70_RS12230	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H1I70_RS12240	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H1I70_RS12245	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H1I70_RS12245	COG0517	IMP dehydrogenase activity
H1I70_RS12290	COG2814	Major facilitator Superfamily
H1I70_RS12325	COG1278	Cold shock
H1I70_RS12330	COG1280	lysine exporter protein (LysE YggA)
H1I70_RS12360	COG1570	exodeoxyribonuclease VII activity
H1I70_RS12410	COG0583	DNA-binding transcription factor activity
H1I70_RS12415	COG4638	Rieske (2fe-2S)
H1I70_RS12420	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H1I70_RS12425	COG0633	Ferredoxin
H1I70_RS12425	COG0543	2 iron, 2 sulfur cluster binding
H1I70_RS12430	COG1028	Short-chain dehydrogenase reductase Sdr
H1I70_RS12435	COG3135	benzoate transporter
H1I70_RS12440	COG2814	Major facilitator Superfamily
H1I70_RS12455	COG1643	Atp-dependent helicase
H1I70_RS12460	COG0450	alkyl hydroperoxide reductase
H1I70_RS12470	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H1I70_RS12480	COG3634	alkyl hydroperoxide reductase activity
H1I70_RS12500	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H1I70_RS12505	COG0625	glutathione transferase activity
H1I70_RS12515	COG2885	chlorophyll binding
H1I70_RS12550	COG0542	response to heat
H1I70_RS12565	COG1765	OsmC-like protein
H1I70_RS12585	COG0667	Aldo Keto reductase
H1I70_RS12600	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H1I70_RS12610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H1I70_RS12620	COG0527	aspartate kinase activity
H1I70_RS12630	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H1I70_RS12640	COG3038	cytochrome b561
H1I70_RS12645	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H1I70_RS12650	COG2252	PERMEase
H1I70_RS12660	COG2072	flavoprotein involved in K transport
H1I70_RS12675	COG1741	Belongs to the pirin family
H1I70_RS12680	COG1309	transcriptional regulator
H1I70_RS12690	COG0300	oxidoreductase activity
H1I70_RS12790	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H1I70_RS12820	COG1113	amino acid transport
H1I70_RS12840	COG1012	belongs to the aldehyde dehydrogenase family
H1I70_RS12860	COG0531	amino acid
H1I70_RS12870	COG1113	amino acid transport
H1I70_RS12910	COG3209	COG3209 Rhs family protein
H1I70_RS12940	COG4269	membrane
H1I70_RS12955	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I70_RS12955	COG1902	pentaerythritol trinitrate reductase activity
H1I70_RS12965	COG2203	Gaf domain
H1I70_RS12965	COG3706	GGDEF domain
H1I70_RS12965	COG4251	negative regulation of phosphorylation
H1I70_RS12965	COG5001	Diguanylate cyclase
H1I70_RS12975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1I70_RS12995	COG4172	Belongs to the ABC transporter superfamily
H1I70_RS13000	COG4239	(ABC) transporter, permease
H1I70_RS13005	COG4174	ABC transporter (Permease)
H1I70_RS13015	COG1388	LysM domain
H1I70_RS13015	COG0741	lytic transglycosylase activity
H1I70_RS13015	COG1388	LysM domain
H1I70_RS13015	COG0741	lytic transglycosylase activity
H1I70_RS13020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1I70_RS13060	COG0583	DNA-binding transcription factor activity
H1I70_RS13065	COG1279	arginine transmembrane transporter activity
H1I70_RS13085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I70_RS13090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I70_RS13095	COG0006	proline dipeptidase activity
H1I70_RS13180	COG1196	nuclear chromosome segregation
H1I70_RS13180	COG0739	heme binding
H1I70_RS13180	COG0741	lytic transglycosylase activity
H1I70_RS13240	COG4695	Portal protein
H1I70_RS13335	COG0305	Participates in initiation and elongation during chromosome replication
H1I70_RS13350	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H1I70_RS13405	COG2194	sulfuric ester hydrolase activity
H1I70_RS13450	COG0739	heme binding
H1I70_RS13775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H1I70_RS13800	COG3384	dioxygenase
H1I70_RS13810	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H1I70_RS13815	COG2878	Part of a membrane complex involved in electron transport
H1I70_RS13820	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H1I70_RS13845	COG0768	penicillin binding
H1I70_RS13850	COG0742	ribosomal rna small subunit methyltransferase
H1I70_RS13865	COG0830	nickel cation binding
H1I70_RS13910	COG1253	flavin adenine dinucleotide binding
H1I70_RS13915	COG2851	Citrate transporter
H1I70_RS13965	COG1773	rubredoxin
H1I70_RS13970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I70_RS13980	COG0583	DNA-binding transcription factor activity
H1I70_RS14005	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H1I70_RS14010	COG4181	ATPase activity
H1I70_RS14055	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H1I70_RS14075	COG0306	phosphate transporter
H1I70_RS14085	COG3958	Transketolase
H1I70_RS14090	COG3959	Transketolase, thiamine diphosphate binding domain
H1I70_RS14095	COG2271	Major facilitator Superfamily
H1I70_RS14100	COG1028	Short-chain dehydrogenase reductase Sdr
H1I70_RS14105	COG0583	DNA-binding transcription factor activity
H1I70_RS14120	COG2223	nitrite transmembrane transporter activity
H1I70_RS14125	COG2207	Transcriptional regulator
H1I70_RS14130	COG2066	Belongs to the glutaminase family
H1I70_RS14135	COG0242	peptide deformylase activity
H1I70_RS14140	COG0477	Major facilitator Superfamily
H1I70_RS14150	COG0028	Belongs to the TPP enzyme family
H1I70_RS14165	COG1028	Short-chain dehydrogenase reductase Sdr
H1I70_RS14170	COG2267	carboxylic ester hydrolase activity
H1I70_RS14180	COG2271	Major facilitator Superfamily
H1I70_RS14185	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I70_RS14195	COG1028	Short-chain dehydrogenase reductase Sdr
H1I70_RS14215	COG1414	Transcriptional regulator
H1I70_RS14230	COG1024	Enoyl-CoA hydratase
H1I70_RS14240	COG1215	transferase activity, transferring glycosyl groups
H1I70_RS14245	COG0726	polysaccharide deacetylase
H1I70_RS14245	COG1649	PFAM Uncharacterised BCR, COG1649
H1I70_RS14255	COG4681	YaeQ
H1I70_RS14265	COG0523	cobalamin synthesis protein
H1I70_RS14275	COG1607	acyl-coa hydrolase
H1I70_RS14285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I70_RS14290	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I70_RS14295	COG1309	transcriptional regulator
H1I70_RS14320	COG2040	homocysteine
H1I70_RS14325	COG0531	amino acid
H1I70_RS14380	COG1595	DNA-templated transcription, initiation
H1I70_RS14390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I70_RS14395	COG0477	Major facilitator Superfamily
H1I70_RS14415	COG0084	hydrolase, TatD family'
H1I70_RS14450	COG0629	single-stranded DNA binding
H1I70_RS14505	COG0582	viral genome integration into host DNA
H1I70_RS14535	COG1061	Type III restriction enzyme res subunit
H1I70_RS14545	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H1I70_RS14550	COG1192	Involved in chromosome partitioning
H1I70_RS14645	COG0592	DNA-directed DNA polymerase activity
H1I70_RS14685	COG2026	Addiction module toxin, RelE StbE family
H1I70_RS14835	COG3755	Protein conserved in bacteria
H1I70_RS14880	COG1484	DNA-dependent DNA replication
H1I70_RS14970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1I70_RS15040	COG0405	Gamma-glutamyltransferase
H1I70_RS15045	COG2814	Major facilitator Superfamily
H1I70_RS15055	COG2050	protein possibly involved in aromatic compounds catabolism
H1I70_RS15070	COG1090	epimerase
H1I70_RS15090	COG0420	3'-5' exonuclease activity
H1I70_RS15115	COG0735	belongs to the Fur family
H1I70_RS15120	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H1I70_RS15140	COG0121	glutamine amidotransferase
H1I70_RS15155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1I70_RS15165	COG0210	DNA helicase
H1I70_RS15170	COG2885	chlorophyll binding
H1I70_RS15175	COG0204	Acyl-transferase
H1I70_RS15190	COG2894	cell division
H1I70_RS15210	COG1280	lysine exporter protein (LysE YggA)
H1I70_RS15215	COG1674	ftsk spoiiie
H1I70_RS15215	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H1I70_RS15220	COG0492	ferredoxin-NADP+ reductase activity
H1I70_RS15225	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H1I70_RS15235	COG0456	acetyltransferase
H1I70_RS15280	COG1981	membrane
H1I70_RS15295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1I70_RS15295	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H1I70_RS15315	COG1012	belongs to the aldehyde dehydrogenase family
H1I70_RS15325	COG0657	acetylesterase activity
H1I70_RS15335	COG0473	3-isopropylmalate dehydrogenase activity
H1I70_RS15340	COG0583	DNA-binding transcription factor activity
H1I70_RS15360	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H1I70_RS15385	COG0564	pseudouridine synthase activity
H1I70_RS15395	COG0358	DNA primase activity
H1I70_RS15410	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H1I70_RS15440	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H1I70_RS15470	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H1I70_RS15480	COG0351	phosphomethylpyrimidine kinase
H1I70_RS15480	COG0352	thiamine-phosphate diphosphorylase activity
H1I70_RS15480	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H1I70_RS15485	COG1652	LysM domain
H1I70_RS15510	COG1399	metal-binding, possibly nucleic acid-binding protein
H1I70_RS15515	COG3101	peptidyl-lysine hydroxylation
H1I70_RS15520	COG0009	L-threonylcarbamoyladenylate synthase
H1I70_RS15525	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H1I70_RS15530	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H1I70_RS15545	COG4106	trans-aconitate 2-methyltransferase activity
H1I70_RS15560	COG2226	methyltransferase
H1I70_RS15560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1I70_RS15560	COG0596	Alpha beta hydrolase
H1I70_RS15565	COG1877	trehalose-phosphatase activity
H1I70_RS15570	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H1I70_RS15575	COG2223	nitrite transmembrane transporter activity
H1I70_RS15595	COG1196	nuclear chromosome segregation
H1I70_RS15605	COG0730	response to heat
H1I70_RS15620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H1I70_RS15630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H1I70_RS15680	COG0489	protein tyrosine kinase activity
H1I70_RS15690	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1I70_RS15690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1I70_RS15720	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H1I70_RS15725	COG2081	HI0933 family
H1I70_RS15735	COG0668	transmembrane transport
H1I70_RS15755	COG0583	DNA-binding transcription factor activity
H1I70_RS15775	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1I70_RS15780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H1I70_RS15810	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H1I70_RS15850	COG0745	RESPONSE REGULATOR receiver
H1I70_RS15870	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H1I70_RS15880	COG2205	protein histidine kinase activity
H1I70_RS15950	COG4993	Dehydrogenase
H1I70_RS15975	COG0384	phenazine biosynthesis protein PhzF
H1I70_RS15995	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I70_RS16010	COG0583	DNA-binding transcription factor activity
H1I70_RS16040	COG0583	DNA-binding transcription factor activity
H1I70_RS16055	COG0583	DNA-binding transcription factor activity
H1I70_RS16060	COG1053	succinate dehydrogenase
H1I70_RS16070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H1I70_RS16075	COG2814	Major facilitator Superfamily
H1I70_RS16080	COG1960	acyl-CoA dehydrogenase activity
H1I70_RS16085	COG0583	DNA-binding transcription factor activity
H1I70_RS16090	COG1063	alcohol dehydrogenase
H1I70_RS16120	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H1I70_RS16125	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H1I70_RS16130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H1I70_RS16145	COG3667	copper resistance
H1I70_RS16150	COG2132	Multicopper oxidase
H1I70_RS16160	COG0561	phosphatase activity
H1I70_RS16165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H1I70_RS16190	COG1214	PFAM Peptidase M22, glycoprotease
H1I70_RS16240	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H1I70_RS16250	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H1I70_RS16255	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H1I70_RS16260	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H1I70_RS16320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1I70_RS16330	COG1846	Transcriptional regulator
H1I70_RS16335	COG1764	response to oxidative stress
H1I70_RS16375	COG0037	tRNA processing
H1I70_RS16385	COG0248	Ppx GppA phosphatase
H1I70_RS16415	COG0072	phenylalanine-tRNA ligase activity
H1I70_RS16455	COG1238	metal cluster binding
H1I70_RS16460	COG0625	glutathione transferase activity
H1I70_RS16475	COG0318	PFAM AMP-dependent synthetase and ligase
H1I70_RS16480	COG3028	Belongs to the UPF0307 family
H1I70_RS16485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1I70_RS16505	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H1I70_RS16510	COG0617	tRNA 3'-terminal CCA addition
H1I70_RS16515	COG1555	photosystem II stabilization
H1I70_RS16520	COG3956	TIGRFAM MazG family protein
H1I70_RS16530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H1I70_RS16550	COG0784	Response regulator, receiver
H1I70_RS16550	COG2205	protein histidine kinase activity
H1I70_RS16550	COG5002	protein histidine kinase activity
H1I70_RS16555	COG1024	Enoyl-CoA hydratase
H1I70_RS16560	COG2084	Dehydrogenase
H1I70_RS16565	COG3622	Belongs to the hyi family
H1I70_RS16595	COG0697	spore germination
H1I70_RS16605	COG2814	Major facilitator Superfamily
H1I70_RS16610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H1I70_RS16620	COG0583	DNA-binding transcription factor activity
H1I70_RS16630	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H1I70_RS16645	COG0084	hydrolase, TatD family'
H1I70_RS16660	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H1I70_RS16690	COG0440	acetolactate synthase activity
H1I70_RS16695	COG0028	Belongs to the TPP enzyme family
H1I70_RS16720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I70_RS16725	COG1136	(ABC) transporter
H1I70_RS16725	COG0577	efflux transmembrane transporter activity
H1I70_RS16730	COG1538	Outer membrane efflux protein
H1I70_RS16745	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H1I70_RS16750	COG1162	GTPase activity
H1I70_RS16760	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H1I70_RS16780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H1I70_RS16785	COG1028	Short-chain dehydrogenase reductase Sdr
H1I70_RS16825	COG2986	histidine ammonia-lyase
H1I70_RS16840	COG0318	PFAM AMP-dependent synthetase and ligase
H1I70_RS16850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1I70_RS16895	COG1426	Protein conserved in bacteria
H1I70_RS16930	COG0793	Belongs to the peptidase S41A family
H1I70_RS16945	COG2267	carboxylic ester hydrolase activity
H1I70_RS16955	COG1012	belongs to the aldehyde dehydrogenase family
H1I70_RS16960	COG3265	gluconokinase activity
H1I70_RS16970	COG0800	Aldolase
H1I70_RS16980	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H1I70_RS16985	COG0280	phosphate acetyltransferase
H1I70_RS16985	COG0857	belongs to the CobB CobQ family
H1I70_RS16990	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H1I70_RS16990	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H1I70_RS17010	COG0740	serine-type endopeptidase activity
H1I70_RS17020	COG4774	siderophore transport
H1I70_RS17030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H1I70_RS17040	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1I70_RS17040	COG2813	Specifically methylates the guanine in position
H1I70_RS17140	COG0788	formyltetrahydrofolate deformylase activity
H1I70_RS17165	COG4651	solute:proton antiporter activity
H1I70_RS17165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1I70_RS17185	COG0724	RNA recognition motif
H1I70_RS17190	COG0210	DNA helicase
H1I70_RS17215	COG1733	regulation of RNA biosynthetic process
H1I70_RS17225	COG2900	Belongs to the SlyX family
H1I70_RS17230	COG0488	(ABC) transporter
H1I70_RS17235	COG1280	lysine exporter protein (LysE YggA)
H1I70_RS17240	COG1560	Kdo2-lipid A biosynthetic process
H1I70_RS17250	COG1301	dicarboxylic acid transport
H1I70_RS17305	COG0473	3-isopropylmalate dehydrogenase activity
H1I70_RS17370	COG0583	DNA-binding transcription factor activity
H1I70_RS17380	COG0625	glutathione transferase activity
H1I70_RS17385	COG2378	regulation of single-species biofilm formation
H1I70_RS17390	COG0546	phosphoglycolate phosphatase activity
H1I70_RS17400	COG1530	ribonuclease E activity
H1I70_RS17405	COG0318	PFAM AMP-dependent synthetase and ligase
H1I70_RS17420	COG0583	DNA-binding transcription factor activity
H1I70_RS17425	COG4221	oxidoreductase activity
H1I70_RS17430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H1I70_RS17440	COG0534	Mate efflux family protein
H1I70_RS17455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H1I70_RS17495	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H1I70_RS17500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1I70_RS17515	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H1I70_RS17525	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H1I70_RS17525	COG0644	oxidoreductase
H1I70_RS17530	COG0425	Belongs to the sulfur carrier protein TusA family
H1I70_RS17535	COG4535	Mg2 and Co2 transporter CorC
H1I70_RS17545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1I70_RS17565	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H1I70_RS17570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1I70_RS17570	COG0475	glutathione-regulated potassium exporter activity
H1I70_RS17575	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H1I70_RS17585	COG0484	heat shock protein binding
H1I70_RS17590	COG0789	Transcriptional regulator
H1I70_RS17595	COG0598	Magnesium transport protein CorA
H1I70_RS17610	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H1I70_RS17615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1I70_RS17620	COG1074	ATP-dependent DNA helicase activity
H1I70_RS17625	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H1I70_RS17645	COG2226	methyltransferase
H1I70_RS17660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I70_RS17665	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H1I70_RS17680	COG2111	Na H antiporter
H1I70_RS17680	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H1I70_RS17685	COG1006	Multisubunit Na H antiporter MnhC subunit
H1I70_RS17690	COG0651	ATP synthesis coupled electron transport
H1I70_RS17695	COG1863	multisubunit Na H antiporter MnhE subunit
H1I70_RS17700	COG2212	antiporter activity
H1I70_RS17705	COG1320	monovalent cation:proton antiporter activity
H1I70_RS17720	COG0195	Participates in both transcription termination and antitermination
H1I70_RS17770	COG0237	dephospho-CoA kinase activity
H1I70_RS17780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1I70_RS17795	COG0497	DNA recombination
H1I70_RS17805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H1I70_RS17835	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H1I70_RS17835	COG2169	Transcriptional regulator
H1I70_RS17840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H1I70_RS17905	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H1I70_RS17920	COG0326	Molecular chaperone. Has ATPase activity
H1I70_RS17935	COG2056	Na+-H+ antiporter family
H1I70_RS17940	COG0596	Alpha beta hydrolase
H1I70_RS18035	COG0546	phosphoglycolate phosphatase activity
H1I70_RS18040	COG1716	ATPase activity
H1I70_RS18085	COG0181	hydroxymethylbilane synthase activity
H1I70_RS18095	COG3275	phosphorelay sensor kinase activity
H1I70_RS18115	COG1538	Outer membrane efflux protein
H1I70_RS18120	COG0697	spore germination
H1I70_RS18145	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H1I70_RS18150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H1I70_RS18155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1I70_RS18160	COG0772	Belongs to the SEDS family
H1I70_RS18185	COG4974	Belongs to the 'phage' integrase family
H1I70_RS18190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1I70_RS18200	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H1I70_RS18210	COG2197	response regulator
H1I70_RS18225	COG0793	Belongs to the peptidase S41A family
H1I70_RS18230	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H1I70_RS18235	COG0795	lipopolysaccharide-transporting ATPase activity
H1I70_RS18275	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1I70_RS18275	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1I70_RS18285	COG0004	ammonium transporteR
H1I70_RS18290	COG0347	Belongs to the P(II) protein family
H1I70_RS18300	COG0606	chelatase, subunit chli
H1I70_RS18350	COG0659	secondary active sulfate transmembrane transporter activity
H1I70_RS18355	COG0589	response to stress
H1I70_RS18395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1I70_RS18440	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H1I70_RS18470	COG0659	secondary active sulfate transmembrane transporter activity
H1I70_RS18475	COG0589	response to stress
H1I70_RS18505	COG0606	chelatase, subunit chli
H1I70_RS18510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I70_RS18520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I70_RS18535	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H1I70_RS18550	COG0318	PFAM AMP-dependent synthetase and ligase
H1I70_RS18560	COG0477	Major facilitator Superfamily
H1I70_RS18565	COG2860	membrane
H1I70_RS18575	COG1253	flavin adenine dinucleotide binding
H1I70_RS18595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H1I70_RS18630	COG0655	NAD(P)H dehydrogenase (quinone) activity
H1I70_RS18640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H1I70_RS18675	COG1309	transcriptional regulator
H1I70_RS18710	COG0758	DNA mediated transformation
H1I70_RS18720	COG0697	spore germination
H1I70_RS18725	COG1309	transcriptional regulator
H1I70_RS18740	COG0386	Belongs to the glutathione peroxidase family
H1I70_RS18805	COG1121	(ABC) transporter
H1I70_RS18810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H1I70_RS18815	COG1280	lysine exporter protein (LysE YggA)
H1I70_RS18820	COG2837	iron assimilation
H1I70_RS18830	COG0281	malic enzyme
H1I70_RS18875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H1I70_RS18875	COG0519	Catalyzes the synthesis of GMP from XMP
H1I70_RS18880	COG4399	Belongs to the UPF0754 family
H1I70_RS18885	COG2259	Doxx family
H1I70_RS18890	COG0586	Pfam SNARE associated Golgi protein
H1I70_RS18905	COG1192	Involved in chromosome partitioning
H1I70_RS18915	COG0271	Belongs to the BolA IbaG family
H1I70_RS18935	COG2267	carboxylic ester hydrolase activity
H1I70_RS18955	COG4221	oxidoreductase activity
H1I70_RS18955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1I70_RS18955	COG0300	oxidoreductase activity
H1I70_RS18955	COG3321	synthase
H1I70_RS18960	COG1960	acyl-CoA dehydrogenase activity
H1I70_RS18970	COG2197	response regulator
H1I70_RS18980	COG3916	Acyl-homoserine-lactone synthase
H1I70_RS18985	COG0477	Major facilitator Superfamily
H1I70_RS18990	COG1024	Enoyl-CoA hydratase
H1I70_RS18995	COG1024	Enoyl-CoA hydratase
H1I70_RS19000	COG1960	acyl-CoA dehydrogenase activity
H1I70_RS19005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1I70_RS19025	COG1113	amino acid transport
H1I70_RS19030	COG1113	amino acid transport
H1I70_RS19035	COG0251	oxidation-reduction process
H1I70_RS19075	COG0564	pseudouridine synthase activity
H1I70_RS19135	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H1I70_RS19150	COG1802	Transcriptional regulator
H1I70_RS19160	COG1448	Aminotransferase
H1I70_RS19165	COG0277	FAD linked oxidase domain protein
H1I70_RS19175	COG2186	Transcriptional regulator
H1I70_RS19185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1I70_RS19190	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H1I70_RS19205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H1I70_RS19210	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H1I70_RS19215	COG1216	Glycosyl transferase, family 2
H1I70_RS19245	COG2089	acid synthase
H1I70_RS19260	COG1083	cytidylyl-transferase
H1I70_RS19265	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H1I70_RS19270	COG1086	Polysaccharide biosynthesis protein
H1I70_RS19275	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H1I70_RS19280	COG1596	polysaccharide export
H1I70_RS19305	COG0728	peptidoglycan biosynthetic process
H1I70_RS19310	COG3023	N-Acetylmuramoyl-L-alanine amidase
H1I70_RS19365	COG0546	phosphoglycolate phosphatase activity
H1I70_RS19370	COG1028	Short-chain dehydrogenase reductase Sdr
H1I70_RS19390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I70_RS19395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I70_RS19400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1I70_RS19405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I70_RS19410	COG1116	anion transmembrane transporter activity
H1I70_RS19415	COG1309	transcriptional regulator
H1I70_RS19420	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H1I70_RS19430	COG0196	riboflavin kinase activity
H1I70_RS19435	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H1I70_RS19445	COG1047	Peptidyl-prolyl cis-trans
H1I70_RS19485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H1I70_RS19490	COG0657	acetylesterase activity
H1I70_RS19540	COG2951	lytic endotransglycosylase activity
H1I70_RS19545	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H1I70_RS19560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H1I70_RS19570	COG0671	phosphoesterase, PA-phosphatase related
H1I70_RS19575	COG0861	Integral membrane protein TerC family
H1I70_RS19585	COG0754	glutathionylspermidine amidase activity
H1I70_RS19595	COG0402	S-adenosylhomocysteine deaminase activity
H1I70_RS19610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1I70_RS19615	COG1230	cation diffusion facilitator family transporter
H1I70_RS19630	COG0706	membrane insertase activity