locus-tag	class	description
H1I69_RS00010	COG0592	DNA-directed DNA polymerase activity
H1I69_RS00020	COG0187	DNA topoisomerase II activity
H1I69_RS00030	COG0586	Pfam SNARE associated Golgi protein
H1I69_RS00035	COG0488	(ABC) transporter
H1I69_RS00060	COG0596	Alpha beta hydrolase
H1I69_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H1I69_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H1I69_RS00110	COG0733	neurotransmitter:sodium symporter activity
H1I69_RS00145	COG0583	DNA-binding transcription factor activity
H1I69_RS00150	COG2233	PERMEase
H1I69_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I69_RS00220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I69_RS00225	COG1064	alcohol dehydrogenase
H1I69_RS00230	COG2818	Glycosylase
H1I69_RS00245	COG1194	a g-specific adenine glycosylase
H1I69_RS00265	COG2983	Belongs to the UPF0260 family
H1I69_RS00270	COG2133	pyrroloquinoline quinone binding
H1I69_RS00275	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H1I69_RS00280	COG2116	formate transmembrane transporter activity
H1I69_RS00300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I69_RS00305	COG1335	isochorismatase
H1I69_RS00310	COG0385	Bile acid
H1I69_RS00315	COG0534	Mate efflux family protein
H1I69_RS00320	COG1683	Conserved Protein
H1I69_RS00340	COG0625	glutathione transferase activity
H1I69_RS00350	COG1113	amino acid transport
H1I69_RS00360	COG0523	cobalamin synthesis protein
H1I69_RS00370	COG2188	Transcriptional regulator
H1I69_RS00400	COG0010	Belongs to the arginase family
H1I69_RS00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H1I69_RS00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H1I69_RS00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H1I69_RS00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H1I69_RS00540	COG0534	Mate efflux family protein
H1I69_RS00545	COG0436	Aminotransferase
H1I69_RS00550	COG2733	membrane
H1I69_RS00565	COG2918	glutathione biosynthetic process
H1I69_RS00585	COG1388	LysM domain
H1I69_RS00585	COG0791	NLP P60 protein
H1I69_RS00600	COG3150	esterase
H1I69_RS00610	COG1028	Short-chain dehydrogenase reductase Sdr
H1I69_RS00615	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H1I69_RS00625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I69_RS00635	COG2233	PERMEase
H1I69_RS00640	COG2351	hydroxyisourate hydrolase activity
H1I69_RS00675	COG3706	GGDEF domain
H1I69_RS00690	COG1393	Belongs to the ArsC family
H1I69_RS00695	COG0708	Exodeoxyribonuclease III
H1I69_RS00715	COG0189	ligase activity
H1I69_RS00735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H1I69_RS00745	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H1I69_RS00760	COG4942	peptidase
H1I69_RS00770	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1I69_RS00780	COG2119	membrane
H1I69_RS00785	COG4774	siderophore transport
H1I69_RS00790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I69_RS00790	COG0426	domain, Protein
H1I69_RS00815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H1I69_RS00835	COG1902	pentaerythritol trinitrate reductase activity
H1I69_RS00840	COG1519	Transferase
H1I69_RS00845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H1I69_RS00850	COG0668	transmembrane transport
H1I69_RS00860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1I69_RS00865	COG1335	isochorismatase
H1I69_RS00870	COG1522	sequence-specific DNA binding
H1I69_RS00875	COG3328	transposase activity
H1I69_RS00900	COG0784	Response regulator, receiver
H1I69_RS00900	COG2198	Histidine kinase
H1I69_RS00900	COG2205	protein histidine kinase activity
H1I69_RS00905	COG3162	membrane
H1I69_RS00910	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H1I69_RS00920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I69_RS00940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H1I69_RS00945	COG1309	transcriptional regulator
H1I69_RS00965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H1I69_RS00965	COG0352	thiamine-phosphate diphosphorylase activity
H1I69_RS00965	COG0351	phosphomethylpyrimidine kinase
H1I69_RS00975	COG2814	Major facilitator Superfamily
H1I69_RS01010	COG1002	Type II restriction enzyme, methylase subunits
H1I69_RS01020	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H1I69_RS01035	COG1002	Type II restriction enzyme, methylase subunits
H1I69_RS01045	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H1I69_RS01055	COG1113	amino acid transport
H1I69_RS01065	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1I69_RS01070	COG1012	belongs to the aldehyde dehydrogenase family
H1I69_RS01080	COG1335	isochorismatase
H1I69_RS01110	COG2814	Major facilitator Superfamily
H1I69_RS01115	COG0583	DNA-binding transcription factor activity
H1I69_RS01135	COG0667	Aldo Keto reductase
H1I69_RS01170	COG1733	regulation of RNA biosynthetic process
H1I69_RS01175	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I69_RS01240	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H1I69_RS01255	COG2329	Antibiotic biosynthesis monooxygenase
H1I69_RS01285	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H1I69_RS01315	COG0427	acetyl-CoA hydrolase
H1I69_RS01340	COG0659	secondary active sulfate transmembrane transporter activity
H1I69_RS01345	COG4221	oxidoreductase activity
H1I69_RS01350	COG2873	o-acetylhomoserine
H1I69_RS01355	COG0488	(ABC) transporter
H1I69_RS01435	COG0833	amino acid
H1I69_RS01480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H1I69_RS01485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H1I69_RS01500	COG2226	methyltransferase
H1I69_RS01550	COG0069	glutamate synthase activity
H1I69_RS01550	COG0067	glutamate synthase
H1I69_RS01550	COG0070	glutamate synthase
H1I69_RS01555	COG0493	'glutamate synthase
H1I69_RS01565	COG1704	LemA family
H1I69_RS01570	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H1I69_RS01585	COG4969	Belongs to the N-Me-Phe pilin family
H1I69_RS01610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H1I69_RS01625	COG0194	GDP metabolic process
H1I69_RS01675	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H1I69_RS01695	COG5380	lipid catabolic process
H1I69_RS01700	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H1I69_RS01725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H1I69_RS01730	COG0277	FAD linked oxidase domain protein
H1I69_RS01740	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H1I69_RS01745	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I69_RS01760	COG1289	transmembrane transporter activity
H1I69_RS01770	COG0628	permease
H1I69_RS01775	COG1192	Involved in chromosome partitioning
H1I69_RS01805	COG0833	amino acid
H1I69_RS01810	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H1I69_RS01815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H1I69_RS01825	COG1012	belongs to the aldehyde dehydrogenase family
H1I69_RS01865	COG0583	DNA-binding transcription factor activity
H1I69_RS01910	COG0517	IMP dehydrogenase activity
H1I69_RS01915	COG1983	PspC domain protein
H1I69_RS01925	COG1960	acyl-CoA dehydrogenase activity
H1I69_RS01940	COG0408	coproporphyrinogen oxidase activity
H1I69_RS01960	COG0513	Belongs to the DEAD box helicase family
H1I69_RS01970	COG1127	ABC transporter
H1I69_RS01975	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H1I69_RS01985	COG2854	intermembrane phospholipid transfer
H1I69_RS01995	COG0598	Magnesium transport protein CorA
H1I69_RS02005	COG0494	nUDIX hydrolase
H1I69_RS02010	COG1040	competence protein
H1I69_RS02015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H1I69_RS02035	COG1946	Acyl-CoA thioesterase
H1I69_RS02040	COG1301	dicarboxylic acid transport
H1I69_RS02055	COG1959	2 iron, 2 sulfur cluster binding
H1I69_RS02060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I69_RS02060	COG1017	nitric oxide dioxygenase activity
H1I69_RS02065	COG0433	COG0433 Predicted ATPase
H1I69_RS02070	COG0626	cystathionine gamma-synthase activity
H1I69_RS02225	COG1960	acyl-CoA dehydrogenase activity
H1I69_RS02230	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H1I69_RS02260	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H1I69_RS02265	COG0339	signal peptide processing
H1I69_RS02270	COG0557	exoribonuclease II activity
H1I69_RS02310	COG0179	Fumarylacetoacetate (FAA) hydrolase
H1I69_RS02315	COG2169	Transcriptional regulator
H1I69_RS02320	COG0697	spore germination
H1I69_RS02325	COG1295	ribonuclease BN
H1I69_RS02360	COG1702	phosphate starvation-inducible protein PhoH
H1I69_RS02370	COG0739	heme binding
H1I69_RS02370	COG0741	lytic transglycosylase activity
H1I69_RS02370	COG1196	nuclear chromosome segregation
H1I69_RS02400	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H1I69_RS02405	COG1183	phosphatidylcholine synthase activity
H1I69_RS02450	COG1960	acyl-CoA dehydrogenase activity
H1I69_RS02455	COG1309	transcriptional regulator
H1I69_RS02470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H1I69_RS02475	COG1960	acyl-CoA dehydrogenase activity
H1I69_RS02495	COG2969	positive regulation of protein catabolic process
H1I69_RS02505	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H1I69_RS02520	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H1I69_RS02525	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H1I69_RS02545	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H1I69_RS02555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1I69_RS02560	COG1408	metallophosphoesterase
H1I69_RS02570	COG2199	diguanylate cyclase activity
H1I69_RS02630	COG1607	acyl-coa hydrolase
H1I69_RS02660	COG2350	Protein conserved in bacteria
H1I69_RS02670	COG0613	PHP domain protein
H1I69_RS02675	COG3781	membrane
H1I69_RS02685	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H1I69_RS02690	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H1I69_RS02700	COG1862	Preprotein translocase
H1I69_RS02730	COG2205	protein histidine kinase activity
H1I69_RS02735	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H1I69_RS02755	COG0726	polysaccharide deacetylase
H1I69_RS02760	COG0463	Glycosyl transferase, family 2
H1I69_RS02765	COG0438	transferase activity, transferring glycosyl groups
H1I69_RS02830	COG0625	glutathione transferase activity
H1I69_RS02835	COG0583	DNA-binding transcription factor activity
H1I69_RS02840	COG1960	acyl-CoA dehydrogenase activity
H1I69_RS02845	COG1960	acyl-CoA dehydrogenase activity
H1I69_RS02855	COG2205	protein histidine kinase activity
H1I69_RS02860	COG0745	RESPONSE REGULATOR receiver
H1I69_RS02865	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H1I69_RS02885	COG2096	Adenosyltransferase
H1I69_RS02935	COG0285	dihydrofolate synthase activity
H1I69_RS02955	COG0450	alkyl hydroperoxide reductase
H1I69_RS02970	COG0477	Major facilitator Superfamily
H1I69_RS02975	COG1272	protein, Hemolysin III
H1I69_RS03005	COG0183	Belongs to the thiolase family
H1I69_RS03010	COG2207	Transcriptional regulator
H1I69_RS03030	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I69_RS03050	COG0183	Belongs to the thiolase family
H1I69_RS03060	COG2885	chlorophyll binding
H1I69_RS03060	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H1I69_RS03070	COG1690	Belongs to the RtcB family
H1I69_RS03075	COG0833	amino acid
H1I69_RS03085	COG2233	PERMEase
H1I69_RS03090	COG1217	gtp-binding protein TYPA
H1I69_RS03115	COG2094	Belongs to the DNA glycosylase MPG family
H1I69_RS03135	COG1902	pentaerythritol trinitrate reductase activity
H1I69_RS03150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1I69_RS03155	COG0354	folic acid binding
H1I69_RS03165	COG3189	MarR family transcriptional regulator
H1I69_RS03170	COG2824	Alkylphosphonate utilization operon protein PhnA
H1I69_RS03175	COG3422	double-strand break repair
H1I69_RS03215	COG0840	transmembrane signaling receptor activity
H1I69_RS03235	COG5510	response to toxic substance
H1I69_RS03245	COG2832	Protein of unknown function (DUF454)
H1I69_RS03250	COG1376	ErfK ybiS ycfS ynhG family protein
H1I69_RS03290	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H1I69_RS03300	COG1289	transmembrane transporter activity
H1I69_RS03305	COG2814	Major facilitator Superfamily
H1I69_RS03325	COG1115	amino acid carrier protein
H1I69_RS03330	COG1752	Esterase of the alpha-beta hydrolase superfamily
H1I69_RS03335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H1I69_RS03340	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H1I69_RS03370	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H1I69_RS03380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H1I69_RS03385	COG1077	Cell shape determining protein MreB Mrl
H1I69_RS03390	COG1792	Involved in formation and maintenance of cell shape
H1I69_RS03395	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H1I69_RS03400	COG0424	maF-like protein
H1I69_RS03405	COG1530	ribonuclease E activity
H1I69_RS03415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I69_RS03425	COG0560	Phosphoserine phosphatase
H1I69_RS03435	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I69_RS03460	COG2207	Transcriptional regulator
H1I69_RS03480	COG1113	amino acid transport
H1I69_RS03485	COG2828	Protein conserved in bacteria
H1I69_RS03490	COG0142	geranyltranstransferase activity
H1I69_RS03495	COG2315	Protein conserved in bacteria
H1I69_RS03510	COG1752	Esterase of the alpha-beta hydrolase superfamily
H1I69_RS03530	COG2194	sulfuric ester hydrolase activity
H1I69_RS03535	COG0745	RESPONSE REGULATOR receiver
H1I69_RS03540	COG0642	Histidine kinase
H1I69_RS03550	COG0004	ammonium transporteR
H1I69_RS03555	COG0583	DNA-binding transcription factor activity
H1I69_RS03575	COG0525	valine-tRNA ligase activity
H1I69_RS03585	COG1028	Short-chain dehydrogenase reductase Sdr
H1I69_RS03595	COG0393	Putative heavy-metal-binding
H1I69_RS03600	COG0393	Putative heavy-metal-binding
H1I69_RS03605	COG1538	Outer membrane efflux protein
H1I69_RS03615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I69_RS03620	COG0671	phosphoesterase, PA-phosphatase related
H1I69_RS03650	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H1I69_RS03665	COG1648	precorrin-2 dehydrogenase activity
H1I69_RS03665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H1I69_RS03670	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H1I69_RS03675	COG1733	regulation of RNA biosynthetic process
H1I69_RS03685	COG0531	amino acid
H1I69_RS03710	COG0321	lipoyl(octanoyl) transferase activity
H1I69_RS03715	COG2921	Belongs to the UPF0250 family
H1I69_RS03755	COG2009	succinate dehydrogenase
H1I69_RS03760	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H1I69_RS03765	COG1053	succinate dehydrogenase
H1I69_RS03770	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H1I69_RS03795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1I69_RS03815	COG2354	Protein conserved in bacteria
H1I69_RS03820	COG2321	neutral zinc metallopeptidase
H1I69_RS03840	COG2843	Capsule synthesis protein
H1I69_RS03855	COG0589	response to stress
H1I69_RS03875	COG0505	Belongs to the CarA family
H1I69_RS03900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1I69_RS03905	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H1I69_RS03955	COG0477	Major facilitator Superfamily
H1I69_RS03960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H1I69_RS03975	COG1597	lipid kinase activity
H1I69_RS03980	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H1I69_RS04010	COG0584	glycerophosphoryl diester phosphodiesterase
H1I69_RS04030	COG0741	lytic transglycosylase activity
H1I69_RS04050	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H1I69_RS04065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I69_RS04095	COG0778	Nitroreductase
H1I69_RS04110	COG1929	Belongs to the glycerate kinase type-1 family
H1I69_RS04115	COG0243	molybdopterin cofactor binding
H1I69_RS04120	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H1I69_RS04125	COG3339	Conserved Protein
H1I69_RS04135	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H1I69_RS04150	COG1113	amino acid transport
H1I69_RS04160	COG0019	diaminopimelate decarboxylase activity
H1I69_RS04170	COG1280	lysine exporter protein (LysE YggA)
H1I69_RS04175	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H1I69_RS04205	COG0463	Glycosyl transferase, family 2
H1I69_RS04225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I69_RS04260	COG4591	ABC-type transport system involved in lipoprotein release permease component
H1I69_RS04265	COG1136	(ABC) transporter
H1I69_RS04270	COG2333	competence protein COMEC
H1I69_RS04270	COG0658	competence protein
H1I69_RS04280	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H1I69_RS04280	COG0616	signal peptide processing
H1I69_RS04285	COG0596	Alpha beta hydrolase
H1I69_RS04290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H1I69_RS04300	COG0628	permease
H1I69_RS04335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1I69_RS04355	COG0823	Involved in the tonB-independent uptake of proteins
H1I69_RS04375	COG0824	Thioesterase
H1I69_RS04380	COG1473	amidohydrolase
H1I69_RS04400	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H1I69_RS04400	COG0047	phosphoribosylformylglycinamidine synthase activity
H1I69_RS04405	COG2814	Major facilitator Superfamily
H1I69_RS04415	COG1024	Enoyl-CoA hydratase
H1I69_RS04420	COG1051	belongs to the nudix hydrolase family
H1I69_RS04420	COG1056	cytidyltransferase-related domain
H1I69_RS04430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H1I69_RS04445	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H1I69_RS04460	COG4625	pathogenesis
H1I69_RS04465	COG0583	DNA-binding transcription factor activity
H1I69_RS04470	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H1I69_RS04475	COG4208	sulfate ABC transporter
H1I69_RS04480	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H1I69_RS04490	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H1I69_RS04495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H1I69_RS04500	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H1I69_RS04520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1I69_RS04535	COG0681	Belongs to the peptidase S26 family
H1I69_RS04550	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H1I69_RS04560	COG1381	Involved in DNA repair and RecF pathway recombination
H1I69_RS04565	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H1I69_RS04575	COG4221	oxidoreductase activity
H1I69_RS04605	COG0436	Aminotransferase
H1I69_RS04625	COG0556	nucleotide-excision repair
H1I69_RS04680	COG2070	2-Nitropropane dioxygenase
H1I69_RS04710	COG1215	transferase activity, transferring glycosyl groups
H1I69_RS04725	COG0415	Belongs to the DNA photolyase family
H1I69_RS04735	COG1252	NADH dehydrogenase
H1I69_RS04740	COG1686	Belongs to the peptidase S11 family
H1I69_RS04755	COG1187	pseudouridine synthase activity
H1I69_RS04780	COG0477	Major facilitator Superfamily
H1I69_RS04785	COG0583	DNA-binding transcription factor activity
H1I69_RS04800	COG0612	Peptidase, M16
H1I69_RS04825	COG0352	thiamine-phosphate diphosphorylase activity
H1I69_RS04860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I69_RS04875	COG1309	transcriptional regulator
H1I69_RS04885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1I69_RS04890	COG0076	glutamate decarboxylase activity
H1I69_RS04900	COG1522	sequence-specific DNA binding
H1I69_RS04905	COG3961	Belongs to the TPP enzyme family
H1I69_RS04910	COG1113	amino acid transport
H1I69_RS04915	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H1I69_RS04920	COG0573	inorganic phosphate transmembrane transporter activity
H1I69_RS04930	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H1I69_RS04935	COG0616	signal peptide processing
H1I69_RS04945	COG3328	transposase activity
H1I69_RS04975	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H1I69_RS04980	COG1686	Belongs to the peptidase S11 family
H1I69_RS05005	COG0583	DNA-binding transcription factor activity
H1I69_RS05010	COG1067	ATP-dependent peptidase activity
H1I69_RS05055	COG1966	Carbon starvation protein
H1I69_RS05060	COG2879	small protein
H1I69_RS05095	COG2508	Transcriptional regulator
H1I69_RS05095	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H1I69_RS05115	COG1113	amino acid transport
H1I69_RS05120	COG0583	DNA-binding transcription factor activity
H1I69_RS05125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I69_RS05130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I69_RS05140	COG1012	belongs to the aldehyde dehydrogenase family
H1I69_RS05150	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I69_RS05155	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H1I69_RS05155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1I69_RS05190	COG2814	Major facilitator Superfamily
H1I69_RS05195	COG4948	Mandelate Racemase Muconate Lactonizing
H1I69_RS05205	COG1309	transcriptional regulator
H1I69_RS05225	COG1741	Belongs to the pirin family
H1I69_RS05235	COG2964	Protein conserved in bacteria
H1I69_RS05250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I69_RS05255	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1I69_RS05260	COG4605	iron ion homeostasis
H1I69_RS05265	COG4604	ABC transporter, ATP-binding protein
H1I69_RS05270	COG4607	ABC-type enterochelin transport system periplasmic component
H1I69_RS05275	COG4774	siderophore transport
H1I69_RS05285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I69_RS05290	COG1021	2,3-dihydroxybenzoate-AMP ligase
H1I69_RS05295	COG1535	isochorismatase
H1I69_RS05295	COG3433	isochorismatase activity
H1I69_RS05310	COG1132	(ABC) transporter
H1I69_RS05315	COG1132	(ABC) transporter
H1I69_RS05320	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H1I69_RS05330	COG1169	isochorismate synthase
H1I69_RS05345	COG3739	integral membrane protein
H1I69_RS05370	COG0302	gtp cyclohydrolase
H1I69_RS05380	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1I69_RS05410	COG0308	aminopeptidase N
H1I69_RS05415	COG0512	Glutamine amidotransferase of anthranilate synthase
H1I69_RS05430	COG0174	glutamine synthetase
H1I69_RS05440	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H1I69_RS05475	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H1I69_RS05480	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H1I69_RS05485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1I69_RS05505	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H1I69_RS05510	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H1I69_RS05515	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H1I69_RS05530	COG1960	acyl-CoA dehydrogenase activity
H1I69_RS05535	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H1I69_RS05540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1I69_RS05550	COG2223	nitrite transmembrane transporter activity
H1I69_RS05560	COG0024	Methionine aminopeptidase
H1I69_RS05565	COG0052	Belongs to the universal ribosomal protein uS2 family
H1I69_RS05580	COG2207	Transcriptional regulator
H1I69_RS05605	COG2951	lytic endotransglycosylase activity
H1I69_RS05610	COG0772	Belongs to the SEDS family
H1I69_RS05625	COG0842	Transport permease protein
H1I69_RS05630	COG1131	(ABC) transporter
H1I69_RS05675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I69_RS05690	COG4215	(ABC) transporter
H1I69_RS05695	COG4160	amino acid transport
H1I69_RS05700	COG4598	ABC transporter
H1I69_RS05710	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H1I69_RS05715	COG0826	peptidase U32
H1I69_RS05720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I69_RS05735	COG1720	tRNA m6t6A37 methyltransferase activity
H1I69_RS05745	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H1I69_RS05760	COG0642	Histidine kinase
H1I69_RS05770	COG0494	nUDIX hydrolase
H1I69_RS05780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H1I69_RS05785	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H1I69_RS05790	COG3139	Protein of unknown function (DUF1315)
H1I69_RS05795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H1I69_RS05800	COG1301	dicarboxylic acid transport
H1I69_RS05805	COG1960	acyl-CoA dehydrogenase activity
H1I69_RS05810	COG2819	hydrolase of the alpha beta superfamily
H1I69_RS05820	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H1I69_RS05830	COG2195	Cleaves the N-terminal amino acid of tripeptides
H1I69_RS05835	COG1234	tRNA 3'-trailer cleavage
H1I69_RS05865	COG2363	Small membrane protein
H1I69_RS05890	COG0513	Belongs to the DEAD box helicase family
H1I69_RS05900	COG0778	Nitroreductase
H1I69_RS05930	COG1286	toxin biosynthetic process
H1I69_RS05955	COG4783	chaperone-mediated protein folding
H1I69_RS05960	COG1610	YqeY-like protein
H1I69_RS06060	COG3111	PFAM Bacterial OB fold (BOF) protein
H1I69_RS06085	COG3243	poly(R)-hydroxyalkanoic acid synthase
H1I69_RS06090	COG0786	glutamate:sodium symporter activity
H1I69_RS06100	COG2186	Transcriptional regulator
H1I69_RS06150	COG0477	Major facilitator Superfamily
H1I69_RS06180	COG2985	domain, Protein
H1I69_RS06190	COG2995	paraquat-inducible protein a
H1I69_RS06195	COG3008	intermembrane lipid transfer
H1I69_RS06195	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H1I69_RS06225	COG0488	(ABC) transporter
H1I69_RS06230	COG3173	Aminoglycoside phosphotransferase
H1I69_RS06240	COG2433	Pfam Transposase IS66
H1I69_RS06380	COG0590	tRNA wobble adenosine to inosine editing
H1I69_RS06385	COG2807	transmembrane transport
H1I69_RS06400	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H1I69_RS06415	COG0789	Transcriptional regulator
H1I69_RS06425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I69_RS06445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1I69_RS06455	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I69_RS06470	COG1012	belongs to the aldehyde dehydrogenase family
H1I69_RS06475	COG0531	amino acid
H1I69_RS06480	COG1760	l-serine dehydratase
H1I69_RS06485	COG2030	dehydratase
H1I69_RS06485	COG1012	belongs to the aldehyde dehydrogenase family
H1I69_RS06490	COG3396	Phenylacetate-CoA oxygenase
H1I69_RS06495	COG3460	Phenylacetate-CoA oxygenase
H1I69_RS06500	COG3396	Phenylacetate-CoA oxygenase
H1I69_RS06505	COG2151	metal-sulfur cluster biosynthetic enzyme
H1I69_RS06510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I69_RS06515	COG1024	Enoyl-CoA hydratase
H1I69_RS06520	COG1024	Enoyl-CoA hydratase
H1I69_RS06525	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1I69_RS06530	COG0183	Belongs to the thiolase family
H1I69_RS06535	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H1I69_RS06540	COG3327	negative regulation of DNA-templated transcription, initiation
H1I69_RS06550	COG2050	protein possibly involved in aromatic compounds catabolism
H1I69_RS06585	COG0753	catalase activity
H1I69_RS06590	COG3038	cytochrome b561
H1I69_RS06610	COG2267	carboxylic ester hydrolase activity
H1I69_RS06615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I69_RS06620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1I69_RS06625	COG1012	belongs to the aldehyde dehydrogenase family
H1I69_RS06635	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H1I69_RS06645	COG1012	belongs to the aldehyde dehydrogenase family
H1I69_RS06650	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H1I69_RS06655	COG0583	DNA-binding transcription factor activity
H1I69_RS06665	COG1414	Transcriptional regulator
H1I69_RS06670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I69_RS06680	COG1840	ABC-type Fe3 transport system, periplasmic component
H1I69_RS06685	COG3842	ATPase activity
H1I69_RS06700	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H1I69_RS06705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1I69_RS06710	COG2814	Major facilitator Superfamily
H1I69_RS06715	COG1960	acyl-CoA dehydrogenase activity
H1I69_RS06730	COG1024	Enoyl-CoA hydratase
H1I69_RS06740	COG2814	Major facilitator Superfamily
H1I69_RS06750	COG0183	Belongs to the thiolase family
H1I69_RS06755	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1I69_RS06760	COG1028	Short-chain dehydrogenase reductase Sdr
H1I69_RS06765	COG1024	Enoyl-CoA hydratase
H1I69_RS06770	COG1960	acyl-CoA dehydrogenase activity
H1I69_RS06775	COG2814	Major facilitator Superfamily
H1I69_RS06780	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H1I69_RS06785	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I69_RS06795	COG2814	Major facilitator Superfamily
H1I69_RS06805	COG1960	acyl-CoA dehydrogenase activity
H1I69_RS06820	COG0583	DNA-binding transcription factor activity
H1I69_RS06830	COG4770	biotin carboxylase activity
H1I69_RS06835	COG1024	Enoyl-CoA hydratase
H1I69_RS06840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H1I69_RS06845	COG1960	acyl-CoA dehydrogenase activity
H1I69_RS06850	COG1309	transcriptional regulator
H1I69_RS06855	COG0318	PFAM AMP-dependent synthetase and ligase
H1I69_RS06875	COG0583	DNA-binding transcription factor activity
H1I69_RS06925	COG1028	Short-chain dehydrogenase reductase Sdr
H1I69_RS06945	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H1I69_RS06965	COG0784	Response regulator, receiver
H1I69_RS06965	COG2205	protein histidine kinase activity
H1I69_RS06985	COG0765	amino acid transport
H1I69_RS06990	COG0765	amino acid transport
H1I69_RS06995	COG1126	abc transporter atp-binding protein
H1I69_RS07000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1I69_RS07005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1I69_RS07020	COG1280	lysine exporter protein (LysE YggA)
H1I69_RS07030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H1I69_RS07035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1I69_RS07040	COG1045	serine acetyltransferase
H1I69_RS07055	COG0583	DNA-binding transcription factor activity
H1I69_RS07060	COG0625	glutathione transferase activity
H1I69_RS07065	COG0625	glutathione transferase activity
H1I69_RS07070	COG0583	DNA-binding transcription factor activity
H1I69_RS07080	COG1346	cytolysis
H1I69_RS07100	COG2814	Major facilitator Superfamily
H1I69_RS07110	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H1I69_RS07115	COG3052	prosthetic group binding
H1I69_RS07135	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H1I69_RS07155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I69_RS07165	COG1294	oxidase, subunit
H1I69_RS07170	COG1271	oxidase subunit
H1I69_RS07195	COG0477	Major facilitator Superfamily
H1I69_RS07205	COG4521	taurine ABC transporter
H1I69_RS07210	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H1I69_RS07215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I69_RS07220	COG2175	clavaminate synthase activity
H1I69_RS07230	COG1953	Uracil, thiamine, allantoin
H1I69_RS07240	COG0583	DNA-binding transcription factor activity
H1I69_RS07250	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H1I69_RS07265	COG0640	Transcriptional regulator
H1I69_RS07270	COG0798	PFAM Bile acid sodium symporter
H1I69_RS07275	COG0583	DNA-binding transcription factor activity
H1I69_RS07290	COG3634	alkyl hydroperoxide reductase activity
H1I69_RS07330	COG0436	Aminotransferase
H1I69_RS07340	COG0386	Belongs to the glutathione peroxidase family
H1I69_RS07380	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H1I69_RS07405	COG0012	GTP binding
H1I69_RS07410	COG2011	ABC-type metal ion transport system permease component
H1I69_RS07415	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H1I69_RS07425	COG1464	Belongs to the NlpA lipoprotein family
H1I69_RS07455	COG0765	amino acid transport
H1I69_RS07460	COG0765	amino acid transport
H1I69_RS07465	COG1126	abc transporter atp-binding protein
H1I69_RS07475	COG1522	sequence-specific DNA binding
H1I69_RS07490	COG1309	transcriptional regulator
H1I69_RS07510	COG0583	DNA-binding transcription factor activity
H1I69_RS07520	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H1I69_RS07530	COG0697	spore germination
H1I69_RS07555	COG3121	Chaperone
H1I69_RS07560	COG3539	Fimbrial protein
H1I69_RS07585	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H1I69_RS07585	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H1I69_RS07630	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H1I69_RS07640	COG2353	YceI-like domain
H1I69_RS07650	COG3698	Phosphodiester glycosidase
H1I69_RS07665	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H1I69_RS07670	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H1I69_RS07670	COG0506	proline dehydrogenase activity
H1I69_RS07670	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H1I69_RS07680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H1I69_RS07685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H1I69_RS07705	COG1132	(ABC) transporter
H1I69_RS07710	COG3122	Protein conserved in bacteria
H1I69_RS07715	COG3619	membrane
H1I69_RS07730	COG0640	Transcriptional regulator
H1I69_RS07740	COG2850	peptidyl-arginine hydroxylation
H1I69_RS07745	COG0424	maF-like protein
H1I69_RS07765	COG0191	fructose-bisphosphate aldolase activity
H1I69_RS07770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H1I69_RS07785	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H1I69_RS07795	COG1192	Involved in chromosome partitioning
H1I69_RS07800	COG1475	DNA binding
H1I69_RS07805	COG0811	peptide transport
H1I69_RS07815	COG1132	(ABC) transporter
H1I69_RS07820	COG1663	tetraacyldisaccharide 4'-kinase activity
H1I69_RS07840	COG0084	hydrolase, TatD family'
H1I69_RS07905	COG0776	regulation of translation
H1I69_RS07935	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H1I69_RS07940	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H1I69_RS07990	COG0339	signal peptide processing
H1I69_RS08000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1I69_RS08035	COG0702	epimerase
H1I69_RS08040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H1I69_RS08060	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H1I69_RS08090	COG0316	Belongs to the HesB IscA family
H1I69_RS08095	COG0822	iron-sulfur transferase activity
H1I69_RS08120	COG0776	regulation of translation
H1I69_RS08125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H1I69_RS08130	COG2207	Transcriptional regulator
H1I69_RS08135	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1I69_RS08140	COG1960	acyl-CoA dehydrogenase activity
H1I69_RS08145	COG1960	acyl-CoA dehydrogenase activity
H1I69_RS08160	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H1I69_RS08180	COG4264	IucA IucC family
H1I69_RS08185	COG4264	IucA IucC family
H1I69_RS08225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1I69_RS08240	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H1I69_RS08260	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H1I69_RS08265	COG0730	response to heat
H1I69_RS08285	COG4773	Receptor
H1I69_RS08290	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1I69_RS08305	COG1131	(ABC) transporter
H1I69_RS08310	COG0842	Transport permease protein
H1I69_RS08315	COG0842	Transport permease protein
H1I69_RS08370	COG2226	methyltransferase
H1I69_RS08395	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H1I69_RS08430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1I69_RS08440	COG0133	tryptophan synthase activity
H1I69_RS08455	COG3706	GGDEF domain
H1I69_RS08470	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H1I69_RS08475	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H1I69_RS08480	COG0022	dehydrogenase e1 component
H1I69_RS08485	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1I69_RS08490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1I69_RS08500	COG1063	alcohol dehydrogenase
H1I69_RS08505	COG3781	membrane
H1I69_RS08515	COG3453	Protein conserved in bacteria
H1I69_RS08515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1I69_RS08530	COG0730	response to heat
H1I69_RS08550	COG2207	Transcriptional regulator
H1I69_RS08550	COG3708	Transcriptional regulator
H1I69_RS08555	COG1733	regulation of RNA biosynthetic process
H1I69_RS08560	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H1I69_RS08570	COG2188	Transcriptional regulator
H1I69_RS08585	COG4521	taurine ABC transporter
H1I69_RS08590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I69_RS08610	COG0477	Major facilitator Superfamily
H1I69_RS08620	COG1027	Aspartate ammonia-lyase
H1I69_RS08635	COG0583	DNA-binding transcription factor activity
H1I69_RS08640	COG0583	DNA-binding transcription factor activity
H1I69_RS08645	COG0183	Belongs to the thiolase family
H1I69_RS08650	COG2031	fatty acid transporter
H1I69_RS08655	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I69_RS08665	COG0583	DNA-binding transcription factor activity
H1I69_RS08675	COG2610	gluconate transmembrane transporter activity
H1I69_RS08680	COG1028	Short-chain dehydrogenase reductase Sdr
H1I69_RS08690	COG2207	Transcriptional regulator
H1I69_RS08705	COG1028	Short-chain dehydrogenase reductase Sdr
H1I69_RS08730	COG0543	2 iron, 2 sulfur cluster binding
H1I69_RS08730	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I69_RS08735	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H1I69_RS08740	COG4638	Rieske (2fe-2S)
H1I69_RS08750	COG0725	ABC transporter, periplasmic molybdate-binding protein
H1I69_RS08755	COG4149	molybdate abc transporter
H1I69_RS08760	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H1I69_RS08765	COG1028	Short-chain dehydrogenase reductase Sdr
H1I69_RS08770	COG1535	isochorismatase
H1I69_RS08770	COG3433	isochorismatase activity
H1I69_RS08830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1I69_RS08845	COG0753	catalase activity
H1I69_RS08855	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H1I69_RS08885	COG3539	Fimbrial protein
H1I69_RS08905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1I69_RS08925	COG2072	flavoprotein involved in K transport
H1I69_RS08935	COG1538	Outer membrane efflux protein
H1I69_RS08940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1I69_RS08945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I69_RS08950	COG0745	RESPONSE REGULATOR receiver
H1I69_RS08955	COG2205	protein histidine kinase activity
H1I69_RS08965	COG2207	Transcriptional regulator
H1I69_RS08980	COG1028	Short-chain dehydrogenase reductase Sdr
H1I69_RS09030	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H1I69_RS09150	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H1I69_RS09170	COG1120	ATPase activity
H1I69_RS09175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1I69_RS09185	COG1064	alcohol dehydrogenase
H1I69_RS09200	COG2207	Transcriptional regulator
H1I69_RS09205	COG2084	Dehydrogenase
H1I69_RS09215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1I69_RS09220	COG0583	DNA-binding transcription factor activity
H1I69_RS09230	COG0129	dihydroxy-acid dehydratase activity
H1I69_RS09235	COG1012	belongs to the aldehyde dehydrogenase family
H1I69_RS09250	COG1566	PFAM secretion protein HlyD family protein
H1I69_RS09285	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H1I69_RS09315	COG0583	DNA-binding transcription factor activity
H1I69_RS09330	COG2188	Transcriptional regulator
H1I69_RS09360	COG3210	domain, Protein
H1I69_RS09365	COG2831	hemolysin activation secretion protein
H1I69_RS09375	COG1473	amidohydrolase
H1I69_RS09385	COG0475	glutathione-regulated potassium exporter activity
H1I69_RS09385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1I69_RS09395	COG0583	DNA-binding transcription factor activity
H1I69_RS09400	COG1335	isochorismatase
H1I69_RS09410	COG1309	transcriptional regulator
H1I69_RS09440	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H1I69_RS09450	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I69_RS09450	COG1902	pentaerythritol trinitrate reductase activity
H1I69_RS09455	COG1846	Transcriptional regulator
H1I69_RS09475	COG0753	catalase activity
H1I69_RS09490	COG1012	belongs to the aldehyde dehydrogenase family
H1I69_RS09505	COG3162	membrane
H1I69_RS09515	COG3829	transcription factor binding
H1I69_RS09520	COG1028	Short-chain dehydrogenase reductase Sdr
H1I69_RS09525	COG1960	acyl-CoA dehydrogenase activity
H1I69_RS09545	COG1012	belongs to the aldehyde dehydrogenase family
H1I69_RS09565	COG2186	Transcriptional regulator
H1I69_RS09575	COG0583	DNA-binding transcription factor activity
H1I69_RS09580	COG4948	Mandelate Racemase Muconate Lactonizing
H1I69_RS09585	COG4829	muconolactone delta-isomerase
H1I69_RS09595	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H1I69_RS09600	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I69_RS09605	COG0183	Belongs to the thiolase family
H1I69_RS09610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1I69_RS09620	COG1012	belongs to the aldehyde dehydrogenase family
H1I69_RS09630	COG3733	amine oxidase
H1I69_RS09640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I69_RS09650	COG1028	Short-chain dehydrogenase reductase Sdr
H1I69_RS09660	COG4638	Rieske (2fe-2S)
H1I69_RS09680	COG0154	amidase activity
H1I69_RS09690	COG2814	Major facilitator Superfamily
H1I69_RS09715	COG1960	acyl-CoA dehydrogenase activity
H1I69_RS09720	COG0583	DNA-binding transcription factor activity
H1I69_RS09725	COG1414	Transcriptional regulator
H1I69_RS09740	COG2391	methyltransferase activity
H1I69_RS09750	COG4993	Dehydrogenase
H1I69_RS09755	COG3659	wide pore channel activity
H1I69_RS09760	COG3420	alginic acid biosynthetic process
H1I69_RS09765	COG0710	3-dehydroquinate dehydratase activity
H1I69_RS09770	COG3485	protocatechuate 3,4-dioxygenase
H1I69_RS09775	COG3485	protocatechuate 3,4-dioxygenase
H1I69_RS09780	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H1I69_RS09785	COG2271	Major facilitator Superfamily
H1I69_RS09790	COG0596	Alpha beta hydrolase
H1I69_RS09795	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H1I69_RS09800	COG0183	Belongs to the thiolase family
H1I69_RS09805	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I69_RS09810	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H1I69_RS09820	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H1I69_RS09825	COG2323	membrane
H1I69_RS09870	COG1902	pentaerythritol trinitrate reductase activity
H1I69_RS09870	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I69_RS09895	COG0542	response to heat
H1I69_RS09900	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H1I69_RS09930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H1I69_RS09935	COG0569	domain protein
H1I69_RS09940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H1I69_RS09955	COG4774	siderophore transport
H1I69_RS09960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1I69_RS09970	COG1585	Membrane protein implicated in regulation of membrane protease activity
H1I69_RS09985	COG1294	oxidase, subunit
H1I69_RS09990	COG4890	Cyd operon protein YbgT
H1I69_RS10005	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H1I69_RS10015	COG0552	protein localization to endoplasmic reticulum
H1I69_RS10040	COG0517	IMP dehydrogenase activity
H1I69_RS10040	COG0516	GMP reductase activity
H1I69_RS10045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H1I69_RS10050	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H1I69_RS10060	COG0583	DNA-binding transcription factor activity
H1I69_RS10065	COG0024	Methionine aminopeptidase
H1I69_RS10095	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1I69_RS10095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H1I69_RS10100	COG1105	Belongs to the carbohydrate kinase PfkB family
H1I69_RS10105	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H1I69_RS10105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H1I69_RS10105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H1I69_RS10125	COG5001	Diguanylate cyclase
H1I69_RS10125	COG3300	MHYT domain
H1I69_RS10140	COG2135	peptidase activity
H1I69_RS10145	COG0659	secondary active sulfate transmembrane transporter activity
H1I69_RS10165	COG1113	amino acid transport
H1I69_RS10175	COG1522	sequence-specific DNA binding
H1I69_RS10200	COG1011	Hydrolase
H1I69_RS10205	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H1I69_RS10215	COG2137	regulation of response to DNA damage stimulus
H1I69_RS10230	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1I69_RS10265	COG0575	Belongs to the CDS family
H1I69_RS10270	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H1I69_RS10290	COG3852	Histidine kinase
H1I69_RS10295	COG2204	response regulator
H1I69_RS10350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H1I69_RS10355	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H1I69_RS10375	COG0697	spore germination
H1I69_RS10380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I69_RS10390	COG0303	'Molybdopterin
H1I69_RS10395	COG0315	cyclic pyranopterin monophosphate synthase activity
H1I69_RS10395	COG0521	Mo-molybdopterin cofactor biosynthetic process
H1I69_RS10410	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H1I69_RS10415	COG0243	molybdopterin cofactor binding
H1I69_RS10425	COG0243	molybdopterin cofactor binding
H1I69_RS10430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I69_RS10435	COG2146	nitrite reductase [NAD(P)H] activity
H1I69_RS10435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I69_RS10445	COG0745	RESPONSE REGULATOR receiver
H1I69_RS10450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I69_RS10450	COG1116	anion transmembrane transporter activity
H1I69_RS10470	COG0511	ligase activity, forming carbon-carbon bonds
H1I69_RS10485	COG2814	Major facilitator Superfamily
H1I69_RS10690	COG5410	chromosome segregation
H1I69_RS10860	COG0069	glutamate synthase activity
H1I69_RS10880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H1I69_RS10890	COG1454	alcohol dehydrogenase
H1I69_RS10895	COG0824	Thioesterase
H1I69_RS10905	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H1I69_RS10920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H1I69_RS10925	COG2030	dehydratase
H1I69_RS10935	COG0183	Belongs to the thiolase family
H1I69_RS10945	COG0583	DNA-binding transcription factor activity
H1I69_RS10950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H1I69_RS10960	COG1522	sequence-specific DNA binding
H1I69_RS10965	COG3135	benzoate transporter
H1I69_RS10975	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H1I69_RS11000	COG0589	response to stress
H1I69_RS11005	COG0488	(ABC) transporter
H1I69_RS11025	COG4773	Receptor
H1I69_RS11060	COG0668	transmembrane transport
H1I69_RS11070	COG1309	transcriptional regulator
H1I69_RS11090	COG1605	Chorismate mutase
H1I69_RS11120	COG0308	aminopeptidase N
H1I69_RS11140	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H1I69_RS11150	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1I69_RS11155	COG1454	alcohol dehydrogenase
H1I69_RS11175	COG0531	amino acid
H1I69_RS11180	COG4303	Ethanolamine ammonia lyase large subunit
H1I69_RS11185	COG4302	ethanolamine ammonia-lyase activity
H1I69_RS11190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H1I69_RS11190	COG0519	Catalyzes the synthesis of GMP from XMP
H1I69_RS11195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1I69_RS11205	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1I69_RS11220	COG0697	spore germination
H1I69_RS11225	COG1923	regulation of RNA biosynthetic process
H1I69_RS11235	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H1I69_RS11240	COG0802	atpase or kinase
H1I69_RS11260	COG1187	pseudouridine synthase activity
H1I69_RS11275	COG0583	DNA-binding transcription factor activity
H1I69_RS11290	COG2814	Major facilitator Superfamily
H1I69_RS11295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1I69_RS11320	COG0729	surface antigen
H1I69_RS11340	COG0174	glutamine synthetase
H1I69_RS11345	COG0745	RESPONSE REGULATOR receiver
H1I69_RS11350	COG2205	protein histidine kinase activity
H1I69_RS11360	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H1I69_RS11365	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H1I69_RS11390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I69_RS11395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1I69_RS11400	COG1960	acyl-CoA dehydrogenase activity
H1I69_RS11415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I69_RS11420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I69_RS11440	COG0583	DNA-binding transcription factor activity
H1I69_RS11455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1I69_RS11465	COG3658	cytochrome
H1I69_RS11470	COG1215	transferase activity, transferring glycosyl groups
H1I69_RS11475	COG1649	PFAM Uncharacterised BCR, COG1649
H1I69_RS11475	COG0726	polysaccharide deacetylase
H1I69_RS11500	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H1I69_RS11505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H1I69_RS11515	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H1I69_RS11540	COG0305	Participates in initiation and elongation during chromosome replication
H1I69_RS11545	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H1I69_RS11555	COG1305	Transglutaminase-like
H1I69_RS11565	COG2308	Evidence 4 Homologs of previously reported genes of
H1I69_RS11595	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H1I69_RS11600	COG0138	bifunctional purine biosynthesis protein purh
H1I69_RS11605	COG0151	Belongs to the GarS family
H1I69_RS11610	COG1464	Belongs to the NlpA lipoprotein family
H1I69_RS11615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H1I69_RS11620	COG2011	ABC-type metal ion transport system permease component
H1I69_RS11625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1I69_RS11635	COG1301	dicarboxylic acid transport
H1I69_RS11670	COG1116	anion transmembrane transporter activity
H1I69_RS11675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1I69_RS11685	COG0864	Transcriptional regulator
H1I69_RS11705	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I69_RS11710	COG0439	Biotin carboxylase
H1I69_RS11725	COG1063	alcohol dehydrogenase
H1I69_RS11735	COG1309	transcriptional regulator
H1I69_RS11755	COG0038	chloride channel
H1I69_RS11760	COG4770	biotin carboxylase activity
H1I69_RS11780	COG1914	H( )-stimulated, divalent metal cation uptake system
H1I69_RS11785	COG0583	DNA-binding transcription factor activity
H1I69_RS11835	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1I69_RS11855	COG2814	Major facilitator Superfamily
H1I69_RS11870	COG1560	Kdo2-lipid A biosynthetic process
H1I69_RS11880	COG5006	permease, DMT superfamily
H1I69_RS11885	COG1522	sequence-specific DNA binding
H1I69_RS11900	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H1I69_RS11910	COG4122	O-methyltransferase activity
H1I69_RS11940	COG1538	Outer membrane efflux protein
H1I69_RS11945	COG1137	ATPase activity
H1I69_RS11950	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H1I69_RS11960	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H1I69_RS11965	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H1I69_RS11965	COG0517	IMP dehydrogenase activity
H1I69_RS12000	COG2814	Major facilitator Superfamily
H1I69_RS12035	COG1278	Cold shock
H1I69_RS12040	COG1280	lysine exporter protein (LysE YggA)
H1I69_RS12070	COG1570	exodeoxyribonuclease VII activity
H1I69_RS12120	COG0583	DNA-binding transcription factor activity
H1I69_RS12130	COG4638	Rieske (2fe-2S)
H1I69_RS12135	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H1I69_RS12140	COG0633	Ferredoxin
H1I69_RS12140	COG0543	2 iron, 2 sulfur cluster binding
H1I69_RS12145	COG1028	Short-chain dehydrogenase reductase Sdr
H1I69_RS12150	COG3135	benzoate transporter
H1I69_RS12155	COG2814	Major facilitator Superfamily
H1I69_RS12170	COG1643	Atp-dependent helicase
H1I69_RS12175	COG0450	alkyl hydroperoxide reductase
H1I69_RS12185	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H1I69_RS12195	COG3634	alkyl hydroperoxide reductase activity
H1I69_RS12215	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H1I69_RS12220	COG0625	glutathione transferase activity
H1I69_RS12230	COG2885	chlorophyll binding
H1I69_RS12265	COG0542	response to heat
H1I69_RS12280	COG1765	OsmC-like protein
H1I69_RS12300	COG0667	Aldo Keto reductase
H1I69_RS12315	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H1I69_RS12325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H1I69_RS12335	COG0527	aspartate kinase activity
H1I69_RS12345	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H1I69_RS12355	COG3038	cytochrome b561
H1I69_RS12360	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H1I69_RS12365	COG2252	PERMEase
H1I69_RS12375	COG2072	flavoprotein involved in K transport
H1I69_RS12400	COG1902	pentaerythritol trinitrate reductase activity
H1I69_RS12400	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I69_RS12410	COG3706	GGDEF domain
H1I69_RS12410	COG4251	negative regulation of phosphorylation
H1I69_RS12410	COG5001	Diguanylate cyclase
H1I69_RS12410	COG2203	Gaf domain
H1I69_RS12420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1I69_RS12440	COG4172	Belongs to the ABC transporter superfamily
H1I69_RS12445	COG4239	(ABC) transporter, permease
H1I69_RS12450	COG4174	ABC transporter (Permease)
H1I69_RS12460	COG1388	LysM domain
H1I69_RS12460	COG0741	lytic transglycosylase activity
H1I69_RS12460	COG1388	LysM domain
H1I69_RS12460	COG0741	lytic transglycosylase activity
H1I69_RS12465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1I69_RS12505	COG0583	DNA-binding transcription factor activity
H1I69_RS12510	COG1279	arginine transmembrane transporter activity
H1I69_RS12530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I69_RS12535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I69_RS12540	COG0006	proline dipeptidase activity
H1I69_RS12580	COG2194	sulfuric ester hydrolase activity
H1I69_RS12625	COG0739	heme binding
H1I69_RS12955	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H1I69_RS12980	COG3384	dioxygenase
H1I69_RS12990	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H1I69_RS12995	COG2878	Part of a membrane complex involved in electron transport
H1I69_RS13000	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H1I69_RS13025	COG0768	penicillin binding
H1I69_RS13030	COG0742	ribosomal rna small subunit methyltransferase
H1I69_RS13045	COG0830	nickel cation binding
H1I69_RS13095	COG1253	flavin adenine dinucleotide binding
H1I69_RS13100	COG2851	Citrate transporter
H1I69_RS13155	COG1773	rubredoxin
H1I69_RS13160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I69_RS13170	COG0583	DNA-binding transcription factor activity
H1I69_RS13195	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H1I69_RS13200	COG4181	ATPase activity
H1I69_RS13245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H1I69_RS13265	COG0306	phosphate transporter
H1I69_RS13275	COG3958	Transketolase
H1I69_RS13280	COG3959	Transketolase, thiamine diphosphate binding domain
H1I69_RS13285	COG2271	Major facilitator Superfamily
H1I69_RS13290	COG1028	Short-chain dehydrogenase reductase Sdr
H1I69_RS13295	COG0583	DNA-binding transcription factor activity
H1I69_RS13310	COG2223	nitrite transmembrane transporter activity
H1I69_RS13315	COG2207	Transcriptional regulator
H1I69_RS13320	COG2066	Belongs to the glutaminase family
H1I69_RS13325	COG0242	peptide deformylase activity
H1I69_RS13330	COG0477	Major facilitator Superfamily
H1I69_RS13340	COG0028	Belongs to the TPP enzyme family
H1I69_RS13355	COG1028	Short-chain dehydrogenase reductase Sdr
H1I69_RS13360	COG2267	carboxylic ester hydrolase activity
H1I69_RS13370	COG2271	Major facilitator Superfamily
H1I69_RS13375	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I69_RS13385	COG1028	Short-chain dehydrogenase reductase Sdr
H1I69_RS13405	COG1414	Transcriptional regulator
H1I69_RS13420	COG1024	Enoyl-CoA hydratase
H1I69_RS13430	COG1215	transferase activity, transferring glycosyl groups
H1I69_RS13435	COG0726	polysaccharide deacetylase
H1I69_RS13435	COG1649	PFAM Uncharacterised BCR, COG1649
H1I69_RS13445	COG4681	YaeQ
H1I69_RS13450	COG1301	dicarboxylic acid transport
H1I69_RS13455	COG0523	cobalamin synthesis protein
H1I69_RS13465	COG1607	acyl-coa hydrolase
H1I69_RS13475	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I69_RS13480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I69_RS13485	COG1309	transcriptional regulator
H1I69_RS13510	COG2040	homocysteine
H1I69_RS13515	COG0531	amino acid
H1I69_RS13570	COG1595	DNA-templated transcription, initiation
H1I69_RS13580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I69_RS13585	COG0477	Major facilitator Superfamily
H1I69_RS13605	COG0084	hydrolase, TatD family'
H1I69_RS13640	COG0629	single-stranded DNA binding
H1I69_RS13695	COG0582	viral genome integration into host DNA
H1I69_RS13800	COG0592	DNA-directed DNA polymerase activity
H1I69_RS13840	COG2026	Addiction module toxin, RelE StbE family
H1I69_RS13980	COG1484	DNA-dependent DNA replication
H1I69_RS14070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1I69_RS14140	COG0405	Gamma-glutamyltransferase
H1I69_RS14145	COG2814	Major facilitator Superfamily
H1I69_RS14155	COG2050	protein possibly involved in aromatic compounds catabolism
H1I69_RS14170	COG1090	epimerase
H1I69_RS14190	COG0420	3'-5' exonuclease activity
H1I69_RS14215	COG0735	belongs to the Fur family
H1I69_RS14220	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H1I69_RS14240	COG0121	glutamine amidotransferase
H1I69_RS14255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1I69_RS14265	COG0210	DNA helicase
H1I69_RS14270	COG2885	chlorophyll binding
H1I69_RS14275	COG0204	Acyl-transferase
H1I69_RS14290	COG2894	cell division
H1I69_RS14315	COG1280	lysine exporter protein (LysE YggA)
H1I69_RS14320	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H1I69_RS14320	COG1674	ftsk spoiiie
H1I69_RS14325	COG0492	ferredoxin-NADP+ reductase activity
H1I69_RS14330	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H1I69_RS14340	COG0456	acetyltransferase
H1I69_RS14385	COG1981	membrane
H1I69_RS14400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H1I69_RS14400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1I69_RS14420	COG1012	belongs to the aldehyde dehydrogenase family
H1I69_RS14430	COG0657	acetylesterase activity
H1I69_RS14440	COG0473	3-isopropylmalate dehydrogenase activity
H1I69_RS14445	COG0583	DNA-binding transcription factor activity
H1I69_RS14465	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H1I69_RS14490	COG0564	pseudouridine synthase activity
H1I69_RS14500	COG0358	DNA primase activity
H1I69_RS14515	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H1I69_RS14545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H1I69_RS14575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H1I69_RS14585	COG0352	thiamine-phosphate diphosphorylase activity
H1I69_RS14585	COG0351	phosphomethylpyrimidine kinase
H1I69_RS14585	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H1I69_RS14590	COG1652	LysM domain
H1I69_RS14615	COG1399	metal-binding, possibly nucleic acid-binding protein
H1I69_RS14620	COG3101	peptidyl-lysine hydroxylation
H1I69_RS14625	COG0009	L-threonylcarbamoyladenylate synthase
H1I69_RS14630	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H1I69_RS14635	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H1I69_RS14650	COG4106	trans-aconitate 2-methyltransferase activity
H1I69_RS14665	COG0596	Alpha beta hydrolase
H1I69_RS14665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1I69_RS14665	COG2226	methyltransferase
H1I69_RS14670	COG1877	trehalose-phosphatase activity
H1I69_RS14675	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H1I69_RS14680	COG2223	nitrite transmembrane transporter activity
H1I69_RS14700	COG1196	nuclear chromosome segregation
H1I69_RS14710	COG0730	response to heat
H1I69_RS14725	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H1I69_RS14735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H1I69_RS14785	COG0489	protein tyrosine kinase activity
H1I69_RS14795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1I69_RS14795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1I69_RS14825	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H1I69_RS14830	COG2081	HI0933 family
H1I69_RS14840	COG0668	transmembrane transport
H1I69_RS14860	COG0583	DNA-binding transcription factor activity
H1I69_RS14880	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1I69_RS14885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H1I69_RS14915	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H1I69_RS14955	COG0745	RESPONSE REGULATOR receiver
H1I69_RS14975	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H1I69_RS14985	COG2205	protein histidine kinase activity
H1I69_RS15055	COG4993	Dehydrogenase
H1I69_RS15080	COG0384	phenazine biosynthesis protein PhzF
H1I69_RS15105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I69_RS15120	COG0583	DNA-binding transcription factor activity
H1I69_RS15150	COG0583	DNA-binding transcription factor activity
H1I69_RS15165	COG0583	DNA-binding transcription factor activity
H1I69_RS15170	COG1053	succinate dehydrogenase
H1I69_RS15180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H1I69_RS15185	COG2814	Major facilitator Superfamily
H1I69_RS15190	COG1960	acyl-CoA dehydrogenase activity
H1I69_RS15195	COG0583	DNA-binding transcription factor activity
H1I69_RS15200	COG1063	alcohol dehydrogenase
H1I69_RS15230	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H1I69_RS15235	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H1I69_RS15240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H1I69_RS15255	COG3667	copper resistance
H1I69_RS15260	COG2132	Multicopper oxidase
H1I69_RS15270	COG0561	phosphatase activity
H1I69_RS15275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H1I69_RS15300	COG1214	PFAM Peptidase M22, glycoprotease
H1I69_RS15355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H1I69_RS15365	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H1I69_RS15370	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H1I69_RS15375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H1I69_RS15435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1I69_RS15445	COG1846	Transcriptional regulator
H1I69_RS15450	COG1764	response to oxidative stress
H1I69_RS15500	COG0037	tRNA processing
H1I69_RS15510	COG0248	Ppx GppA phosphatase
H1I69_RS15540	COG0072	phenylalanine-tRNA ligase activity
H1I69_RS15585	COG1238	metal cluster binding
H1I69_RS15590	COG0625	glutathione transferase activity
H1I69_RS15605	COG0318	PFAM AMP-dependent synthetase and ligase
H1I69_RS15610	COG3028	Belongs to the UPF0307 family
H1I69_RS15615	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1I69_RS15635	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H1I69_RS15640	COG0617	tRNA 3'-terminal CCA addition
H1I69_RS15645	COG1555	photosystem II stabilization
H1I69_RS15650	COG3956	TIGRFAM MazG family protein
H1I69_RS15660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H1I69_RS15680	COG0784	Response regulator, receiver
H1I69_RS15680	COG2205	protein histidine kinase activity
H1I69_RS15680	COG5002	protein histidine kinase activity
H1I69_RS15685	COG1024	Enoyl-CoA hydratase
H1I69_RS15690	COG2084	Dehydrogenase
H1I69_RS15695	COG3622	Belongs to the hyi family
H1I69_RS15725	COG0697	spore germination
H1I69_RS15735	COG2814	Major facilitator Superfamily
H1I69_RS15740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H1I69_RS15750	COG0583	DNA-binding transcription factor activity
H1I69_RS15760	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H1I69_RS15775	COG0084	hydrolase, TatD family'
H1I69_RS15790	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H1I69_RS15820	COG0440	acetolactate synthase activity
H1I69_RS15825	COG0028	Belongs to the TPP enzyme family
H1I69_RS15850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I69_RS15855	COG0577	efflux transmembrane transporter activity
H1I69_RS15855	COG1136	(ABC) transporter
H1I69_RS15860	COG1538	Outer membrane efflux protein
H1I69_RS15875	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H1I69_RS15880	COG1162	GTPase activity
H1I69_RS15890	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H1I69_RS15910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H1I69_RS15915	COG1028	Short-chain dehydrogenase reductase Sdr
H1I69_RS15955	COG2986	histidine ammonia-lyase
H1I69_RS15970	COG0318	PFAM AMP-dependent synthetase and ligase
H1I69_RS15980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1I69_RS16025	COG1426	Protein conserved in bacteria
H1I69_RS16060	COG0793	Belongs to the peptidase S41A family
H1I69_RS16075	COG2267	carboxylic ester hydrolase activity
H1I69_RS16085	COG1012	belongs to the aldehyde dehydrogenase family
H1I69_RS16090	COG3265	gluconokinase activity
H1I69_RS16100	COG0800	Aldolase
H1I69_RS16115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H1I69_RS16120	COG0280	phosphate acetyltransferase
H1I69_RS16120	COG0857	belongs to the CobB CobQ family
H1I69_RS16125	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H1I69_RS16125	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H1I69_RS16145	COG0740	serine-type endopeptidase activity
H1I69_RS16155	COG4774	siderophore transport
H1I69_RS16165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H1I69_RS16175	COG2813	Specifically methylates the guanine in position
H1I69_RS16175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1I69_RS16275	COG0788	formyltetrahydrofolate deformylase activity
H1I69_RS16300	COG4651	solute:proton antiporter activity
H1I69_RS16300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1I69_RS16320	COG0724	RNA recognition motif
H1I69_RS16325	COG0210	DNA helicase
H1I69_RS16350	COG1733	regulation of RNA biosynthetic process
H1I69_RS16360	COG2900	Belongs to the SlyX family
H1I69_RS16365	COG0488	(ABC) transporter
H1I69_RS16370	COG1280	lysine exporter protein (LysE YggA)
H1I69_RS16375	COG1560	Kdo2-lipid A biosynthetic process
H1I69_RS16385	COG1301	dicarboxylic acid transport
H1I69_RS16440	COG0473	3-isopropylmalate dehydrogenase activity
H1I69_RS16505	COG0583	DNA-binding transcription factor activity
H1I69_RS16515	COG0625	glutathione transferase activity
H1I69_RS16520	COG2378	regulation of single-species biofilm formation
H1I69_RS16525	COG0546	phosphoglycolate phosphatase activity
H1I69_RS16535	COG1530	ribonuclease E activity
H1I69_RS16540	COG0318	PFAM AMP-dependent synthetase and ligase
H1I69_RS16550	COG0583	DNA-binding transcription factor activity
H1I69_RS16555	COG4221	oxidoreductase activity
H1I69_RS16560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H1I69_RS16570	COG0534	Mate efflux family protein
H1I69_RS16585	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H1I69_RS16625	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H1I69_RS16630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1I69_RS16645	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H1I69_RS16655	COG0644	oxidoreductase
H1I69_RS16655	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H1I69_RS16660	COG0425	Belongs to the sulfur carrier protein TusA family
H1I69_RS16665	COG4535	Mg2 and Co2 transporter CorC
H1I69_RS16675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1I69_RS16695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H1I69_RS16700	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1I69_RS16700	COG0475	glutathione-regulated potassium exporter activity
H1I69_RS16705	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H1I69_RS16715	COG0484	heat shock protein binding
H1I69_RS16720	COG0789	Transcriptional regulator
H1I69_RS16725	COG0598	Magnesium transport protein CorA
H1I69_RS16740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H1I69_RS16745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1I69_RS16750	COG1074	ATP-dependent DNA helicase activity
H1I69_RS16755	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H1I69_RS16775	COG2226	methyltransferase
H1I69_RS16790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I69_RS16795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H1I69_RS16810	COG2111	Na H antiporter
H1I69_RS16810	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H1I69_RS16815	COG1006	Multisubunit Na H antiporter MnhC subunit
H1I69_RS16820	COG0651	ATP synthesis coupled electron transport
H1I69_RS16825	COG1863	multisubunit Na H antiporter MnhE subunit
H1I69_RS16830	COG2212	antiporter activity
H1I69_RS16835	COG1320	monovalent cation:proton antiporter activity
H1I69_RS16850	COG0195	Participates in both transcription termination and antitermination
H1I69_RS16905	COG0237	dephospho-CoA kinase activity
H1I69_RS16915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1I69_RS16930	COG0497	DNA recombination
H1I69_RS16940	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H1I69_RS16970	COG2169	Transcriptional regulator
H1I69_RS16970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H1I69_RS16975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H1I69_RS17040	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H1I69_RS17055	COG0326	Molecular chaperone. Has ATPase activity
H1I69_RS17070	COG2056	Na+-H+ antiporter family
H1I69_RS17075	COG0596	Alpha beta hydrolase
H1I69_RS17170	COG0546	phosphoglycolate phosphatase activity
H1I69_RS17175	COG1716	ATPase activity
H1I69_RS17220	COG0181	hydroxymethylbilane synthase activity
H1I69_RS17230	COG3275	phosphorelay sensor kinase activity
H1I69_RS17250	COG1538	Outer membrane efflux protein
H1I69_RS17255	COG0697	spore germination
H1I69_RS17280	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H1I69_RS17285	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H1I69_RS17290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1I69_RS17295	COG0772	Belongs to the SEDS family
H1I69_RS17320	COG4974	Belongs to the 'phage' integrase family
H1I69_RS17325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1I69_RS17335	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H1I69_RS17345	COG2197	response regulator
H1I69_RS17360	COG0793	Belongs to the peptidase S41A family
H1I69_RS17365	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H1I69_RS17370	COG0795	lipopolysaccharide-transporting ATPase activity
H1I69_RS17410	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1I69_RS17410	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1I69_RS17420	COG0004	ammonium transporteR
H1I69_RS17425	COG0347	Belongs to the P(II) protein family
H1I69_RS17500	COG1061	Type III restriction enzyme res subunit
H1I69_RS17505	COG1002	Type II restriction enzyme, methylase subunits
H1I69_RS17515	COG0659	secondary active sulfate transmembrane transporter activity
H1I69_RS17520	COG0589	response to stress
H1I69_RS17565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I69_RS17585	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H1I69_RS17600	COG0318	PFAM AMP-dependent synthetase and ligase
H1I69_RS17610	COG0477	Major facilitator Superfamily
H1I69_RS17615	COG2860	membrane
H1I69_RS17625	COG1253	flavin adenine dinucleotide binding
H1I69_RS17635	COG2814	Major facilitator Superfamily
H1I69_RS17645	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H1I69_RS17685	COG0655	NAD(P)H dehydrogenase (quinone) activity
H1I69_RS17695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H1I69_RS17765	COG0758	DNA mediated transformation
H1I69_RS17775	COG0697	spore germination
H1I69_RS17780	COG1309	transcriptional regulator
H1I69_RS17795	COG0386	Belongs to the glutathione peroxidase family
H1I69_RS17870	COG1061	Type III restriction enzyme res subunit
H1I69_RS17880	COG1192	Involved in chromosome partitioning
H1I69_RS17885	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H1I69_RS17895	COG1061	Type III restriction enzyme res subunit
H1I69_RS17900	COG1061	Type III restriction enzyme res subunit
H1I69_RS17915	COG1121	(ABC) transporter
H1I69_RS17920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H1I69_RS17925	COG1280	lysine exporter protein (LysE YggA)
H1I69_RS17930	COG2837	iron assimilation
H1I69_RS17935	COG0281	malic enzyme
H1I69_RS17980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H1I69_RS17980	COG0519	Catalyzes the synthesis of GMP from XMP
H1I69_RS17985	COG4399	Belongs to the UPF0754 family
H1I69_RS17990	COG2259	Doxx family
H1I69_RS17995	COG0586	Pfam SNARE associated Golgi protein
H1I69_RS18010	COG1192	Involved in chromosome partitioning
H1I69_RS18020	COG0271	Belongs to the BolA IbaG family
H1I69_RS18035	COG0477	Major facilitator Superfamily
H1I69_RS18040	COG1024	Enoyl-CoA hydratase
H1I69_RS18045	COG1024	Enoyl-CoA hydratase
H1I69_RS18050	COG1960	acyl-CoA dehydrogenase activity
H1I69_RS18055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1I69_RS18075	COG1113	amino acid transport
H1I69_RS18080	COG1113	amino acid transport
H1I69_RS18085	COG0251	oxidation-reduction process
H1I69_RS18125	COG0564	pseudouridine synthase activity
H1I69_RS18175	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H1I69_RS18190	COG1802	Transcriptional regulator
H1I69_RS18200	COG1448	Aminotransferase
H1I69_RS18205	COG0277	FAD linked oxidase domain protein
H1I69_RS18215	COG2186	Transcriptional regulator
H1I69_RS18225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1I69_RS18230	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H1I69_RS18245	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H1I69_RS18255	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H1I69_RS18265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H1I69_RS18270	COG0438	transferase activity, transferring glycosyl groups
H1I69_RS18295	COG1216	Glycosyl transferase, family 2
H1I69_RS18300	COG5039	Polysaccharide pyruvyl transferase
H1I69_RS18305	COG5039	Polysaccharide pyruvyl transferase
H1I69_RS18315	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H1I69_RS18320	COG1596	polysaccharide export
H1I69_RS18345	COG0728	peptidoglycan biosynthetic process
H1I69_RS18350	COG3023	N-Acetylmuramoyl-L-alanine amidase
H1I69_RS18410	COG0546	phosphoglycolate phosphatase activity
H1I69_RS18415	COG1028	Short-chain dehydrogenase reductase Sdr
H1I69_RS18435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I69_RS18445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1I69_RS18450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I69_RS18455	COG1116	anion transmembrane transporter activity
H1I69_RS18460	COG1309	transcriptional regulator
H1I69_RS18465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H1I69_RS18475	COG0196	riboflavin kinase activity
H1I69_RS18480	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H1I69_RS18490	COG1047	Peptidyl-prolyl cis-trans
H1I69_RS18530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H1I69_RS18535	COG0657	acetylesterase activity
H1I69_RS18555	COG0583	DNA-binding transcription factor activity
H1I69_RS18585	COG2951	lytic endotransglycosylase activity
H1I69_RS18590	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H1I69_RS18605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H1I69_RS18615	COG0671	phosphoesterase, PA-phosphatase related
H1I69_RS18620	COG0861	Integral membrane protein TerC family
H1I69_RS18630	COG0754	glutathionylspermidine amidase activity
H1I69_RS18640	COG0402	S-adenosylhomocysteine deaminase activity
H1I69_RS18655	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1I69_RS18660	COG1230	cation diffusion facilitator family transporter
H1I69_RS18675	COG0706	membrane insertase activity
H1I69_RS18700	COG1475	DNA binding
H1I69_RS18955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1I69_RS19145	COG1525	nuclease
H1I69_RS19185	COG1002	Type II restriction enzyme, methylase subunits
H1I69_RS19265	COG3853	Toxic anion resistance protein (TelA)
H1I69_RS19270	COG3853	Toxic anion resistance protein (TelA)