locus-tag	class	description
H1I74_RS00010	COG0592	DNA-directed DNA polymerase activity
H1I74_RS00020	COG0187	DNA topoisomerase II activity
H1I74_RS00030	COG0586	Pfam SNARE associated Golgi protein
H1I74_RS00035	COG0488	(ABC) transporter
H1I74_RS00060	COG0596	Alpha beta hydrolase
H1I74_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H1I74_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H1I74_RS00110	COG0733	neurotransmitter:sodium symporter activity
H1I74_RS00150	COG2233	PERMEase
H1I74_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I74_RS00200	COG2814	Major facilitator Superfamily
H1I74_RS00205	COG0656	L-ascorbic acid biosynthetic process
H1I74_RS00210	COG0583	DNA-binding transcription factor activity
H1I74_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I74_RS00230	COG1064	alcohol dehydrogenase
H1I74_RS00235	COG2818	Glycosylase
H1I74_RS00250	COG1194	a g-specific adenine glycosylase
H1I74_RS00270	COG2983	Belongs to the UPF0260 family
H1I74_RS00275	COG2133	pyrroloquinoline quinone binding
H1I74_RS00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H1I74_RS00285	COG2116	formate transmembrane transporter activity
H1I74_RS00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I74_RS00310	COG1335	isochorismatase
H1I74_RS00315	COG0385	Bile acid
H1I74_RS00320	COG0534	Mate efflux family protein
H1I74_RS00325	COG1683	Conserved Protein
H1I74_RS00345	COG0625	glutathione transferase activity
H1I74_RS00355	COG1113	amino acid transport
H1I74_RS00365	COG0523	cobalamin synthesis protein
H1I74_RS00375	COG2188	Transcriptional regulator
H1I74_RS00405	COG0010	Belongs to the arginase family
H1I74_RS00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H1I74_RS00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H1I74_RS00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H1I74_RS00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H1I74_RS00540	COG0534	Mate efflux family protein
H1I74_RS00545	COG0436	Aminotransferase
H1I74_RS00550	COG2733	membrane
H1I74_RS00565	COG2918	glutathione biosynthetic process
H1I74_RS00580	COG1388	LysM domain
H1I74_RS00580	COG0791	NLP P60 protein
H1I74_RS00595	COG3150	esterase
H1I74_RS00605	COG1028	Short-chain dehydrogenase reductase Sdr
H1I74_RS00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H1I74_RS00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I74_RS00630	COG2233	PERMEase
H1I74_RS00635	COG2351	hydroxyisourate hydrolase activity
H1I74_RS00670	COG3706	GGDEF domain
H1I74_RS00685	COG1393	Belongs to the ArsC family
H1I74_RS00690	COG0708	Exodeoxyribonuclease III
H1I74_RS00710	COG0189	ligase activity
H1I74_RS00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H1I74_RS00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H1I74_RS00755	COG4942	peptidase
H1I74_RS00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1I74_RS00775	COG2119	membrane
H1I74_RS00780	COG4774	siderophore transport
H1I74_RS00785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I74_RS00785	COG0426	domain, Protein
H1I74_RS00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H1I74_RS00830	COG1902	pentaerythritol trinitrate reductase activity
H1I74_RS00835	COG1519	Transferase
H1I74_RS00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H1I74_RS00845	COG0668	transmembrane transport
H1I74_RS00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1I74_RS00860	COG1335	isochorismatase
H1I74_RS00865	COG1522	sequence-specific DNA binding
H1I74_RS00870	COG3328	transposase activity
H1I74_RS00895	COG0784	Response regulator, receiver
H1I74_RS00895	COG2205	protein histidine kinase activity
H1I74_RS00895	COG2198	Histidine kinase
H1I74_RS00900	COG3162	membrane
H1I74_RS00905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H1I74_RS00915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I74_RS00935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H1I74_RS00940	COG1309	transcriptional regulator
H1I74_RS00960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H1I74_RS00960	COG0351	phosphomethylpyrimidine kinase
H1I74_RS00960	COG0352	thiamine-phosphate diphosphorylase activity
H1I74_RS00970	COG2814	Major facilitator Superfamily
H1I74_RS00985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H1I74_RS00995	COG1113	amino acid transport
H1I74_RS01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1I74_RS01010	COG1012	belongs to the aldehyde dehydrogenase family
H1I74_RS01020	COG1335	isochorismatase
H1I74_RS01050	COG2814	Major facilitator Superfamily
H1I74_RS01055	COG0583	DNA-binding transcription factor activity
H1I74_RS01075	COG0667	Aldo Keto reductase
H1I74_RS01110	COG1733	regulation of RNA biosynthetic process
H1I74_RS01115	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I74_RS01180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H1I74_RS01195	COG2329	Antibiotic biosynthesis monooxygenase
H1I74_RS01225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H1I74_RS01255	COG0427	acetyl-CoA hydrolase
H1I74_RS01280	COG0659	secondary active sulfate transmembrane transporter activity
H1I74_RS01285	COG4221	oxidoreductase activity
H1I74_RS01290	COG2873	o-acetylhomoserine
H1I74_RS01295	COG0488	(ABC) transporter
H1I74_RS01380	COG0833	amino acid
H1I74_RS01425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H1I74_RS01430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H1I74_RS01445	COG2226	methyltransferase
H1I74_RS01495	COG0070	glutamate synthase
H1I74_RS01495	COG0067	glutamate synthase
H1I74_RS01495	COG0069	glutamate synthase activity
H1I74_RS01500	COG0493	'glutamate synthase
H1I74_RS01510	COG1704	LemA family
H1I74_RS01515	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H1I74_RS01535	COG3307	-O-antigen
H1I74_RS01555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H1I74_RS01570	COG0194	GDP metabolic process
H1I74_RS01620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H1I74_RS01640	COG5380	lipid catabolic process
H1I74_RS01645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H1I74_RS01670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H1I74_RS01675	COG0277	FAD linked oxidase domain protein
H1I74_RS01685	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H1I74_RS01690	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I74_RS01705	COG1289	transmembrane transporter activity
H1I74_RS01715	COG0628	permease
H1I74_RS01720	COG1192	Involved in chromosome partitioning
H1I74_RS01750	COG0833	amino acid
H1I74_RS01755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H1I74_RS01760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H1I74_RS01770	COG1012	belongs to the aldehyde dehydrogenase family
H1I74_RS01810	COG0583	DNA-binding transcription factor activity
H1I74_RS01855	COG0517	IMP dehydrogenase activity
H1I74_RS01860	COG1983	PspC domain protein
H1I74_RS01870	COG1960	acyl-CoA dehydrogenase activity
H1I74_RS01885	COG0408	coproporphyrinogen oxidase activity
H1I74_RS01905	COG0513	Belongs to the DEAD box helicase family
H1I74_RS01915	COG1127	ABC transporter
H1I74_RS01920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H1I74_RS01930	COG2854	intermembrane phospholipid transfer
H1I74_RS01940	COG0598	Magnesium transport protein CorA
H1I74_RS01950	COG0494	nUDIX hydrolase
H1I74_RS01955	COG1040	competence protein
H1I74_RS01960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H1I74_RS01980	COG1946	Acyl-CoA thioesterase
H1I74_RS01985	COG1301	dicarboxylic acid transport
H1I74_RS02000	COG1959	2 iron, 2 sulfur cluster binding
H1I74_RS02005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I74_RS02005	COG1017	nitric oxide dioxygenase activity
H1I74_RS02010	COG0433	COG0433 Predicted ATPase
H1I74_RS02015	COG0626	cystathionine gamma-synthase activity
H1I74_RS02170	COG1960	acyl-CoA dehydrogenase activity
H1I74_RS02175	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H1I74_RS02205	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H1I74_RS02210	COG0339	signal peptide processing
H1I74_RS02215	COG0557	exoribonuclease II activity
H1I74_RS02260	COG0179	Fumarylacetoacetate (FAA) hydrolase
H1I74_RS02265	COG2169	Transcriptional regulator
H1I74_RS02270	COG0697	spore germination
H1I74_RS02275	COG1295	ribonuclease BN
H1I74_RS02310	COG1702	phosphate starvation-inducible protein PhoH
H1I74_RS02320	COG0739	heme binding
H1I74_RS02320	COG0741	lytic transglycosylase activity
H1I74_RS02320	COG1196	nuclear chromosome segregation
H1I74_RS02350	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H1I74_RS02355	COG1183	phosphatidylcholine synthase activity
H1I74_RS02400	COG1960	acyl-CoA dehydrogenase activity
H1I74_RS02405	COG1309	transcriptional regulator
H1I74_RS02420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H1I74_RS02425	COG1960	acyl-CoA dehydrogenase activity
H1I74_RS02445	COG2969	positive regulation of protein catabolic process
H1I74_RS02455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H1I74_RS02470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H1I74_RS02475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H1I74_RS02495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H1I74_RS02505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1I74_RS02510	COG1408	metallophosphoesterase
H1I74_RS02520	COG2199	diguanylate cyclase activity
H1I74_RS02580	COG1607	acyl-coa hydrolase
H1I74_RS02610	COG2350	Protein conserved in bacteria
H1I74_RS02620	COG0613	PHP domain protein
H1I74_RS02625	COG3781	membrane
H1I74_RS02635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H1I74_RS02640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H1I74_RS02650	COG1862	Preprotein translocase
H1I74_RS02680	COG2205	protein histidine kinase activity
H1I74_RS02685	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H1I74_RS02705	COG0726	polysaccharide deacetylase
H1I74_RS02710	COG0463	Glycosyl transferase, family 2
H1I74_RS02715	COG0438	transferase activity, transferring glycosyl groups
H1I74_RS02785	COG0625	glutathione transferase activity
H1I74_RS02790	COG0583	DNA-binding transcription factor activity
H1I74_RS02795	COG1960	acyl-CoA dehydrogenase activity
H1I74_RS02800	COG1960	acyl-CoA dehydrogenase activity
H1I74_RS02810	COG2205	protein histidine kinase activity
H1I74_RS02815	COG0745	RESPONSE REGULATOR receiver
H1I74_RS02820	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H1I74_RS02840	COG2096	Adenosyltransferase
H1I74_RS02890	COG0285	dihydrofolate synthase activity
H1I74_RS02910	COG0450	alkyl hydroperoxide reductase
H1I74_RS02925	COG0477	Major facilitator Superfamily
H1I74_RS02930	COG1272	protein, Hemolysin III
H1I74_RS02960	COG0183	Belongs to the thiolase family
H1I74_RS02965	COG2207	Transcriptional regulator
H1I74_RS02985	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I74_RS03005	COG0183	Belongs to the thiolase family
H1I74_RS03015	COG2885	chlorophyll binding
H1I74_RS03015	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H1I74_RS03025	COG1690	Belongs to the RtcB family
H1I74_RS03030	COG0833	amino acid
H1I74_RS03040	COG2233	PERMEase
H1I74_RS03045	COG1217	gtp-binding protein TYPA
H1I74_RS03070	COG2094	Belongs to the DNA glycosylase MPG family
H1I74_RS03075	COG4772	TonB-dependent receptor
H1I74_RS03090	COG1902	pentaerythritol trinitrate reductase activity
H1I74_RS03095	COG0679	Auxin Efflux Carrier
H1I74_RS03105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1I74_RS03110	COG0354	folic acid binding
H1I74_RS03120	COG3189	MarR family transcriptional regulator
H1I74_RS03125	COG2824	Alkylphosphonate utilization operon protein PhnA
H1I74_RS03130	COG3422	double-strand break repair
H1I74_RS03170	COG0840	transmembrane signaling receptor activity
H1I74_RS03190	COG5510	response to toxic substance
H1I74_RS03200	COG2832	Protein of unknown function (DUF454)
H1I74_RS03205	COG1376	ErfK ybiS ycfS ynhG family protein
H1I74_RS03245	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H1I74_RS03255	COG1289	transmembrane transporter activity
H1I74_RS03260	COG2814	Major facilitator Superfamily
H1I74_RS03280	COG1115	amino acid carrier protein
H1I74_RS03285	COG1752	Esterase of the alpha-beta hydrolase superfamily
H1I74_RS03290	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H1I74_RS03295	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H1I74_RS03335	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H1I74_RS03345	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H1I74_RS03350	COG1077	Cell shape determining protein MreB Mrl
H1I74_RS03355	COG1792	Involved in formation and maintenance of cell shape
H1I74_RS03360	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H1I74_RS03365	COG0424	maF-like protein
H1I74_RS03370	COG1530	ribonuclease E activity
H1I74_RS03380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I74_RS03390	COG0560	Phosphoserine phosphatase
H1I74_RS03400	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I74_RS03425	COG2207	Transcriptional regulator
H1I74_RS03445	COG1113	amino acid transport
H1I74_RS03450	COG2828	Protein conserved in bacteria
H1I74_RS03455	COG0142	geranyltranstransferase activity
H1I74_RS03460	COG2315	Protein conserved in bacteria
H1I74_RS03475	COG1752	Esterase of the alpha-beta hydrolase superfamily
H1I74_RS03495	COG2194	sulfuric ester hydrolase activity
H1I74_RS03500	COG0745	RESPONSE REGULATOR receiver
H1I74_RS03505	COG0642	Histidine kinase
H1I74_RS03515	COG0004	ammonium transporteR
H1I74_RS03520	COG0583	DNA-binding transcription factor activity
H1I74_RS03540	COG0525	valine-tRNA ligase activity
H1I74_RS03550	COG1028	Short-chain dehydrogenase reductase Sdr
H1I74_RS03560	COG0393	Putative heavy-metal-binding
H1I74_RS03565	COG0393	Putative heavy-metal-binding
H1I74_RS03570	COG1538	Outer membrane efflux protein
H1I74_RS03580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I74_RS03585	COG0671	phosphoesterase, PA-phosphatase related
H1I74_RS03615	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H1I74_RS03630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H1I74_RS03630	COG1648	precorrin-2 dehydrogenase activity
H1I74_RS03635	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H1I74_RS03640	COG1733	regulation of RNA biosynthetic process
H1I74_RS03650	COG0531	amino acid
H1I74_RS03665	COG0321	lipoyl(octanoyl) transferase activity
H1I74_RS03670	COG2921	Belongs to the UPF0250 family
H1I74_RS03710	COG2009	succinate dehydrogenase
H1I74_RS03715	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H1I74_RS03720	COG1053	succinate dehydrogenase
H1I74_RS03725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H1I74_RS03750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1I74_RS03770	COG2354	Protein conserved in bacteria
H1I74_RS03775	COG2321	neutral zinc metallopeptidase
H1I74_RS03820	COG2843	Capsule synthesis protein
H1I74_RS03840	COG0659	secondary active sulfate transmembrane transporter activity
H1I74_RS03845	COG0589	response to stress
H1I74_RS03880	COG0589	response to stress
H1I74_RS03900	COG0505	Belongs to the CarA family
H1I74_RS03925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1I74_RS03930	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H1I74_RS03980	COG0477	Major facilitator Superfamily
H1I74_RS03985	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H1I74_RS04000	COG1597	lipid kinase activity
H1I74_RS04005	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H1I74_RS04035	COG0584	glycerophosphoryl diester phosphodiesterase
H1I74_RS04055	COG0741	lytic transglycosylase activity
H1I74_RS04075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H1I74_RS04090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I74_RS04115	COG0778	Nitroreductase
H1I74_RS04130	COG1929	Belongs to the glycerate kinase type-1 family
H1I74_RS04135	COG0243	molybdopterin cofactor binding
H1I74_RS04140	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H1I74_RS04145	COG3339	Conserved Protein
H1I74_RS04155	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H1I74_RS04170	COG1113	amino acid transport
H1I74_RS04180	COG0019	diaminopimelate decarboxylase activity
H1I74_RS04190	COG1280	lysine exporter protein (LysE YggA)
H1I74_RS04195	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H1I74_RS04225	COG0463	Glycosyl transferase, family 2
H1I74_RS04245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I74_RS04280	COG4591	ABC-type transport system involved in lipoprotein release permease component
H1I74_RS04285	COG1136	(ABC) transporter
H1I74_RS04290	COG2333	competence protein COMEC
H1I74_RS04290	COG0658	competence protein
H1I74_RS04300	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H1I74_RS04300	COG0616	signal peptide processing
H1I74_RS04305	COG0596	Alpha beta hydrolase
H1I74_RS04310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H1I74_RS04320	COG0628	permease
H1I74_RS04365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1I74_RS04385	COG0823	Involved in the tonB-independent uptake of proteins
H1I74_RS04405	COG0824	Thioesterase
H1I74_RS04410	COG1473	amidohydrolase
H1I74_RS04430	COG0047	phosphoribosylformylglycinamidine synthase activity
H1I74_RS04430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H1I74_RS04435	COG2814	Major facilitator Superfamily
H1I74_RS04445	COG1024	Enoyl-CoA hydratase
H1I74_RS04450	COG1051	belongs to the nudix hydrolase family
H1I74_RS04450	COG1056	cytidyltransferase-related domain
H1I74_RS04460	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H1I74_RS04475	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H1I74_RS04490	COG4625	pathogenesis
H1I74_RS04495	COG0583	DNA-binding transcription factor activity
H1I74_RS04500	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H1I74_RS04505	COG4208	sulfate ABC transporter
H1I74_RS04510	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H1I74_RS04520	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H1I74_RS04525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H1I74_RS04530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H1I74_RS04550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1I74_RS04565	COG0681	Belongs to the peptidase S26 family
H1I74_RS04580	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H1I74_RS04590	COG1381	Involved in DNA repair and RecF pathway recombination
H1I74_RS04595	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H1I74_RS04605	COG4221	oxidoreductase activity
H1I74_RS04635	COG0436	Aminotransferase
H1I74_RS04655	COG0556	nucleotide-excision repair
H1I74_RS04710	COG2070	2-Nitropropane dioxygenase
H1I74_RS04740	COG1215	transferase activity, transferring glycosyl groups
H1I74_RS04755	COG0415	Belongs to the DNA photolyase family
H1I74_RS04765	COG1252	NADH dehydrogenase
H1I74_RS04770	COG1686	Belongs to the peptidase S11 family
H1I74_RS04785	COG1187	pseudouridine synthase activity
H1I74_RS04810	COG0477	Major facilitator Superfamily
H1I74_RS04815	COG0583	DNA-binding transcription factor activity
H1I74_RS04820	COG1823	symporter activity
H1I74_RS04840	COG0612	Peptidase, M16
H1I74_RS04865	COG0352	thiamine-phosphate diphosphorylase activity
H1I74_RS04900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I74_RS04915	COG1309	transcriptional regulator
H1I74_RS04925	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1I74_RS04930	COG0076	glutamate decarboxylase activity
H1I74_RS04940	COG1522	sequence-specific DNA binding
H1I74_RS04945	COG3961	Belongs to the TPP enzyme family
H1I74_RS04950	COG1113	amino acid transport
H1I74_RS04955	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H1I74_RS04960	COG0573	inorganic phosphate transmembrane transporter activity
H1I74_RS04970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H1I74_RS04975	COG0616	signal peptide processing
H1I74_RS04985	COG3328	transposase activity
H1I74_RS05015	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H1I74_RS05020	COG1686	Belongs to the peptidase S11 family
H1I74_RS05045	COG0583	DNA-binding transcription factor activity
H1I74_RS05050	COG1067	ATP-dependent peptidase activity
H1I74_RS05095	COG1966	Carbon starvation protein
H1I74_RS05100	COG2879	small protein
H1I74_RS05130	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H1I74_RS05130	COG2508	Transcriptional regulator
H1I74_RS05150	COG1113	amino acid transport
H1I74_RS05155	COG0583	DNA-binding transcription factor activity
H1I74_RS05160	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I74_RS05165	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I74_RS05175	COG1012	belongs to the aldehyde dehydrogenase family
H1I74_RS05180	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I74_RS05185	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H1I74_RS05185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1I74_RS05220	COG2814	Major facilitator Superfamily
H1I74_RS05225	COG4948	Mandelate Racemase Muconate Lactonizing
H1I74_RS05235	COG1309	transcriptional regulator
H1I74_RS05255	COG1741	Belongs to the pirin family
H1I74_RS05265	COG2964	Protein conserved in bacteria
H1I74_RS05280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I74_RS05285	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1I74_RS05290	COG4605	iron ion homeostasis
H1I74_RS05295	COG4604	ABC transporter, ATP-binding protein
H1I74_RS05300	COG4607	ABC-type enterochelin transport system periplasmic component
H1I74_RS05305	COG4774	siderophore transport
H1I74_RS05315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I74_RS05320	COG1021	2,3-dihydroxybenzoate-AMP ligase
H1I74_RS05325	COG1535	isochorismatase
H1I74_RS05325	COG3433	isochorismatase activity
H1I74_RS05340	COG1132	(ABC) transporter
H1I74_RS05345	COG1132	(ABC) transporter
H1I74_RS05350	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H1I74_RS05360	COG1169	isochorismate synthase
H1I74_RS05375	COG3739	integral membrane protein
H1I74_RS05400	COG0302	gtp cyclohydrolase
H1I74_RS05410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1I74_RS05440	COG0308	aminopeptidase N
H1I74_RS05445	COG0512	Glutamine amidotransferase of anthranilate synthase
H1I74_RS05460	COG0174	glutamine synthetase
H1I74_RS05470	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H1I74_RS05505	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H1I74_RS05510	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H1I74_RS05515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1I74_RS05535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H1I74_RS05540	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H1I74_RS05545	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H1I74_RS05560	COG1960	acyl-CoA dehydrogenase activity
H1I74_RS05565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H1I74_RS05570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1I74_RS05580	COG2223	nitrite transmembrane transporter activity
H1I74_RS05590	COG0024	Methionine aminopeptidase
H1I74_RS05595	COG0052	Belongs to the universal ribosomal protein uS2 family
H1I74_RS05610	COG2207	Transcriptional regulator
H1I74_RS05635	COG2951	lytic endotransglycosylase activity
H1I74_RS05640	COG0772	Belongs to the SEDS family
H1I74_RS05655	COG0842	Transport permease protein
H1I74_RS05660	COG1131	(ABC) transporter
H1I74_RS05705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I74_RS05720	COG4215	(ABC) transporter
H1I74_RS05725	COG4160	amino acid transport
H1I74_RS05730	COG4598	ABC transporter
H1I74_RS05740	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H1I74_RS05750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I74_RS05765	COG1720	tRNA m6t6A37 methyltransferase activity
H1I74_RS05775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H1I74_RS05790	COG0642	Histidine kinase
H1I74_RS05800	COG0494	nUDIX hydrolase
H1I74_RS05810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H1I74_RS05815	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H1I74_RS05820	COG3139	Protein of unknown function (DUF1315)
H1I74_RS05825	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H1I74_RS05830	COG1301	dicarboxylic acid transport
H1I74_RS05835	COG1960	acyl-CoA dehydrogenase activity
H1I74_RS05840	COG2819	hydrolase of the alpha beta superfamily
H1I74_RS05855	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H1I74_RS05865	COG2195	Cleaves the N-terminal amino acid of tripeptides
H1I74_RS05870	COG1234	tRNA 3'-trailer cleavage
H1I74_RS05900	COG2363	Small membrane protein
H1I74_RS05920	COG0513	Belongs to the DEAD box helicase family
H1I74_RS05930	COG0778	Nitroreductase
H1I74_RS05960	COG1286	toxin biosynthetic process
H1I74_RS05985	COG4783	chaperone-mediated protein folding
H1I74_RS05990	COG1610	YqeY-like protein
H1I74_RS06090	COG3111	PFAM Bacterial OB fold (BOF) protein
H1I74_RS06115	COG3243	poly(R)-hydroxyalkanoic acid synthase
H1I74_RS06120	COG0786	glutamate:sodium symporter activity
H1I74_RS06130	COG2186	Transcriptional regulator
H1I74_RS06180	COG0477	Major facilitator Superfamily
H1I74_RS06225	COG1301	dicarboxylic acid transport
H1I74_RS06235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1I74_RS06240	COG2011	ABC-type metal ion transport system permease component
H1I74_RS06245	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H1I74_RS06250	COG1464	Belongs to the NlpA lipoprotein family
H1I74_RS06255	COG0151	Belongs to the GarS family
H1I74_RS06260	COG0138	bifunctional purine biosynthesis protein purh
H1I74_RS06265	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H1I74_RS06295	COG2308	Evidence 4 Homologs of previously reported genes of
H1I74_RS06305	COG1305	Transglutaminase-like
H1I74_RS06315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H1I74_RS06320	COG0305	Participates in initiation and elongation during chromosome replication
H1I74_RS06345	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H1I74_RS06355	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H1I74_RS06360	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H1I74_RS06385	COG0726	polysaccharide deacetylase
H1I74_RS06385	COG1649	PFAM Uncharacterised BCR, COG1649
H1I74_RS06390	COG1215	transferase activity, transferring glycosyl groups
H1I74_RS06395	COG3658	cytochrome
H1I74_RS06405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1I74_RS06420	COG0583	DNA-binding transcription factor activity
H1I74_RS06440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I74_RS06445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I74_RS06460	COG1960	acyl-CoA dehydrogenase activity
H1I74_RS06465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1I74_RS06470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I74_RS06495	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H1I74_RS06500	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H1I74_RS06510	COG2205	protein histidine kinase activity
H1I74_RS06515	COG0745	RESPONSE REGULATOR receiver
H1I74_RS06520	COG0174	glutamine synthetase
H1I74_RS06540	COG0729	surface antigen
H1I74_RS06565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1I74_RS06570	COG2814	Major facilitator Superfamily
H1I74_RS06585	COG0583	DNA-binding transcription factor activity
H1I74_RS06600	COG1187	pseudouridine synthase activity
H1I74_RS06620	COG0802	atpase or kinase
H1I74_RS06625	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H1I74_RS06635	COG1923	regulation of RNA biosynthetic process
H1I74_RS06640	COG0697	spore germination
H1I74_RS06655	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1I74_RS06665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1I74_RS06670	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H1I74_RS06670	COG0519	Catalyzes the synthesis of GMP from XMP
H1I74_RS06675	COG4302	ethanolamine ammonia-lyase activity
H1I74_RS06680	COG4303	Ethanolamine ammonia lyase large subunit
H1I74_RS06685	COG0531	amino acid
H1I74_RS06705	COG1454	alcohol dehydrogenase
H1I74_RS06710	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1I74_RS06720	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H1I74_RS06740	COG0308	aminopeptidase N
H1I74_RS06770	COG1605	Chorismate mutase
H1I74_RS06785	COG1309	transcriptional regulator
H1I74_RS06795	COG0668	transmembrane transport
H1I74_RS06830	COG4773	Receptor
H1I74_RS06860	COG0659	secondary active sulfate transmembrane transporter activity
H1I74_RS06865	COG0589	response to stress
H1I74_RS06900	COG0589	response to stress
H1I74_RS06925	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H1I74_RS06935	COG3135	benzoate transporter
H1I74_RS06940	COG1522	sequence-specific DNA binding
H1I74_RS06950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H1I74_RS06955	COG0583	DNA-binding transcription factor activity
H1I74_RS06965	COG0183	Belongs to the thiolase family
H1I74_RS06975	COG2030	dehydratase
H1I74_RS06980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H1I74_RS06995	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H1I74_RS07005	COG0824	Thioesterase
H1I74_RS07010	COG1454	alcohol dehydrogenase
H1I74_RS07020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H1I74_RS07040	COG0069	glutamate synthase activity
H1I74_RS07245	COG5410	chromosome segregation
H1I74_RS07445	COG2814	Major facilitator Superfamily
H1I74_RS07460	COG0511	ligase activity, forming carbon-carbon bonds
H1I74_RS07480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I74_RS07480	COG1116	anion transmembrane transporter activity
H1I74_RS07485	COG0745	RESPONSE REGULATOR receiver
H1I74_RS07495	COG2146	nitrite reductase [NAD(P)H] activity
H1I74_RS07495	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I74_RS07500	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I74_RS07505	COG0243	molybdopterin cofactor binding
H1I74_RS07515	COG0243	molybdopterin cofactor binding
H1I74_RS07520	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H1I74_RS07535	COG0521	Mo-molybdopterin cofactor biosynthetic process
H1I74_RS07535	COG0315	cyclic pyranopterin monophosphate synthase activity
H1I74_RS07540	COG0303	'Molybdopterin
H1I74_RS07550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I74_RS07555	COG0697	spore germination
H1I74_RS07575	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H1I74_RS07580	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H1I74_RS07635	COG2204	response regulator
H1I74_RS07640	COG3852	Histidine kinase
H1I74_RS07660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H1I74_RS07665	COG0575	Belongs to the CDS family
H1I74_RS07700	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1I74_RS07715	COG2137	regulation of response to DNA damage stimulus
H1I74_RS07725	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H1I74_RS07730	COG1011	Hydrolase
H1I74_RS07755	COG1522	sequence-specific DNA binding
H1I74_RS07765	COG1113	amino acid transport
H1I74_RS07780	COG0659	secondary active sulfate transmembrane transporter activity
H1I74_RS07785	COG2135	peptidase activity
H1I74_RS07800	COG3300	MHYT domain
H1I74_RS07800	COG5001	Diguanylate cyclase
H1I74_RS07820	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H1I74_RS07820	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H1I74_RS07820	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H1I74_RS07825	COG1105	Belongs to the carbohydrate kinase PfkB family
H1I74_RS07830	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1I74_RS07830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H1I74_RS07860	COG0024	Methionine aminopeptidase
H1I74_RS07865	COG0583	DNA-binding transcription factor activity
H1I74_RS07875	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H1I74_RS07880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H1I74_RS07885	COG0517	IMP dehydrogenase activity
H1I74_RS07885	COG0516	GMP reductase activity
H1I74_RS07910	COG0552	protein localization to endoplasmic reticulum
H1I74_RS07920	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H1I74_RS07935	COG4890	Cyd operon protein YbgT
H1I74_RS07940	COG1294	oxidase, subunit
H1I74_RS07960	COG1585	Membrane protein implicated in regulation of membrane protease activity
H1I74_RS07970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1I74_RS07975	COG4774	siderophore transport
H1I74_RS07990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H1I74_RS07995	COG0569	domain protein
H1I74_RS08000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H1I74_RS08030	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H1I74_RS08035	COG0542	response to heat
H1I74_RS08060	COG1902	pentaerythritol trinitrate reductase activity
H1I74_RS08060	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I74_RS08105	COG2323	membrane
H1I74_RS08110	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H1I74_RS08120	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H1I74_RS08125	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I74_RS08130	COG0183	Belongs to the thiolase family
H1I74_RS08135	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H1I74_RS08140	COG0596	Alpha beta hydrolase
H1I74_RS08145	COG2271	Major facilitator Superfamily
H1I74_RS08150	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H1I74_RS08155	COG3485	protocatechuate 3,4-dioxygenase
H1I74_RS08160	COG3485	protocatechuate 3,4-dioxygenase
H1I74_RS08165	COG0710	3-dehydroquinate dehydratase activity
H1I74_RS08170	COG3420	alginic acid biosynthetic process
H1I74_RS08175	COG3659	wide pore channel activity
H1I74_RS08180	COG4993	Dehydrogenase
H1I74_RS08190	COG2391	methyltransferase activity
H1I74_RS08205	COG1414	Transcriptional regulator
H1I74_RS08210	COG0583	DNA-binding transcription factor activity
H1I74_RS08215	COG1960	acyl-CoA dehydrogenase activity
H1I74_RS08240	COG2814	Major facilitator Superfamily
H1I74_RS08250	COG0154	amidase activity
H1I74_RS08270	COG4638	Rieske (2fe-2S)
H1I74_RS08280	COG1028	Short-chain dehydrogenase reductase Sdr
H1I74_RS08290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I74_RS08300	COG3733	amine oxidase
H1I74_RS08310	COG1012	belongs to the aldehyde dehydrogenase family
H1I74_RS08320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1I74_RS08325	COG0183	Belongs to the thiolase family
H1I74_RS08330	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I74_RS08335	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H1I74_RS08345	COG4829	muconolactone delta-isomerase
H1I74_RS08350	COG4948	Mandelate Racemase Muconate Lactonizing
H1I74_RS08355	COG0583	DNA-binding transcription factor activity
H1I74_RS08365	COG2186	Transcriptional regulator
H1I74_RS08385	COG1012	belongs to the aldehyde dehydrogenase family
H1I74_RS08405	COG1960	acyl-CoA dehydrogenase activity
H1I74_RS08410	COG1028	Short-chain dehydrogenase reductase Sdr
H1I74_RS08415	COG3829	transcription factor binding
H1I74_RS08425	COG3162	membrane
H1I74_RS08440	COG1012	belongs to the aldehyde dehydrogenase family
H1I74_RS08455	COG0753	catalase activity
H1I74_RS08475	COG1846	Transcriptional regulator
H1I74_RS08480	COG1902	pentaerythritol trinitrate reductase activity
H1I74_RS08480	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I74_RS08490	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H1I74_RS08520	COG1309	transcriptional regulator
H1I74_RS08530	COG1335	isochorismatase
H1I74_RS08535	COG0583	DNA-binding transcription factor activity
H1I74_RS08545	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1I74_RS08545	COG0475	glutathione-regulated potassium exporter activity
H1I74_RS08555	COG1473	amidohydrolase
H1I74_RS08565	COG2831	hemolysin activation secretion protein
H1I74_RS08570	COG3210	domain, Protein
H1I74_RS08600	COG2188	Transcriptional regulator
H1I74_RS08615	COG0583	DNA-binding transcription factor activity
H1I74_RS08645	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H1I74_RS08665	COG1566	PFAM secretion protein HlyD family protein
H1I74_RS08680	COG1012	belongs to the aldehyde dehydrogenase family
H1I74_RS08685	COG0129	dihydroxy-acid dehydratase activity
H1I74_RS08695	COG0583	DNA-binding transcription factor activity
H1I74_RS08700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1I74_RS08710	COG2084	Dehydrogenase
H1I74_RS08715	COG2207	Transcriptional regulator
H1I74_RS08730	COG1064	alcohol dehydrogenase
H1I74_RS08740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1I74_RS08745	COG1120	ATPase activity
H1I74_RS08765	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H1I74_RS08880	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H1I74_RS08930	COG1028	Short-chain dehydrogenase reductase Sdr
H1I74_RS08945	COG2207	Transcriptional regulator
H1I74_RS08955	COG2205	protein histidine kinase activity
H1I74_RS08960	COG0745	RESPONSE REGULATOR receiver
H1I74_RS08965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I74_RS08970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1I74_RS08975	COG1538	Outer membrane efflux protein
H1I74_RS08985	COG2072	flavoprotein involved in K transport
H1I74_RS09005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1I74_RS09025	COG3539	Fimbrial protein
H1I74_RS09055	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H1I74_RS09065	COG0753	catalase activity
H1I74_RS09080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1I74_RS09140	COG3433	isochorismatase activity
H1I74_RS09140	COG1535	isochorismatase
H1I74_RS09145	COG1028	Short-chain dehydrogenase reductase Sdr
H1I74_RS09150	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H1I74_RS09155	COG4149	molybdate abc transporter
H1I74_RS09160	COG0725	ABC transporter, periplasmic molybdate-binding protein
H1I74_RS09170	COG4638	Rieske (2fe-2S)
H1I74_RS09175	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H1I74_RS09180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I74_RS09180	COG0543	2 iron, 2 sulfur cluster binding
H1I74_RS09205	COG1028	Short-chain dehydrogenase reductase Sdr
H1I74_RS09220	COG2207	Transcriptional regulator
H1I74_RS09230	COG1028	Short-chain dehydrogenase reductase Sdr
H1I74_RS09235	COG2610	gluconate transmembrane transporter activity
H1I74_RS09245	COG0583	DNA-binding transcription factor activity
H1I74_RS09255	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I74_RS09260	COG2031	fatty acid transporter
H1I74_RS09265	COG0183	Belongs to the thiolase family
H1I74_RS09270	COG0583	DNA-binding transcription factor activity
H1I74_RS09275	COG0583	DNA-binding transcription factor activity
H1I74_RS09290	COG1027	Aspartate ammonia-lyase
H1I74_RS09300	COG0477	Major facilitator Superfamily
H1I74_RS09320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I74_RS09325	COG4521	taurine ABC transporter
H1I74_RS09340	COG2188	Transcriptional regulator
H1I74_RS09350	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H1I74_RS09355	COG1733	regulation of RNA biosynthetic process
H1I74_RS09360	COG3708	Transcriptional regulator
H1I74_RS09360	COG2207	Transcriptional regulator
H1I74_RS09375	COG0730	response to heat
H1I74_RS09385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1I74_RS09385	COG3453	Protein conserved in bacteria
H1I74_RS09395	COG3781	membrane
H1I74_RS09400	COG1063	alcohol dehydrogenase
H1I74_RS09410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1I74_RS09415	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1I74_RS09420	COG0022	dehydrogenase e1 component
H1I74_RS09425	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H1I74_RS09430	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H1I74_RS09445	COG3706	GGDEF domain
H1I74_RS09460	COG0133	tryptophan synthase activity
H1I74_RS09470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1I74_RS09505	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H1I74_RS09530	COG2226	methyltransferase
H1I74_RS09585	COG0842	Transport permease protein
H1I74_RS09590	COG0842	Transport permease protein
H1I74_RS09595	COG1131	(ABC) transporter
H1I74_RS09610	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1I74_RS09615	COG4773	Receptor
H1I74_RS09635	COG0730	response to heat
H1I74_RS09640	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H1I74_RS09660	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H1I74_RS09675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1I74_RS09715	COG4264	IucA IucC family
H1I74_RS09720	COG4264	IucA IucC family
H1I74_RS09740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H1I74_RS09755	COG1960	acyl-CoA dehydrogenase activity
H1I74_RS09760	COG1960	acyl-CoA dehydrogenase activity
H1I74_RS09765	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1I74_RS09770	COG2207	Transcriptional regulator
H1I74_RS09775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H1I74_RS09780	COG0776	regulation of translation
H1I74_RS09805	COG0822	iron-sulfur transferase activity
H1I74_RS09810	COG0316	Belongs to the HesB IscA family
H1I74_RS09840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H1I74_RS09860	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H1I74_RS09865	COG0702	epimerase
H1I74_RS09900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1I74_RS09910	COG0339	signal peptide processing
H1I74_RS09960	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H1I74_RS09965	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H1I74_RS09995	COG0776	regulation of translation
H1I74_RS10060	COG0084	hydrolase, TatD family'
H1I74_RS10080	COG1663	tetraacyldisaccharide 4'-kinase activity
H1I74_RS10085	COG1132	(ABC) transporter
H1I74_RS10095	COG0811	peptide transport
H1I74_RS10100	COG1475	DNA binding
H1I74_RS10105	COG1192	Involved in chromosome partitioning
H1I74_RS10115	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H1I74_RS10130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H1I74_RS10135	COG0191	fructose-bisphosphate aldolase activity
H1I74_RS10155	COG0424	maF-like protein
H1I74_RS10160	COG2850	peptidyl-arginine hydroxylation
H1I74_RS10170	COG0640	Transcriptional regulator
H1I74_RS10185	COG3619	membrane
H1I74_RS10190	COG3122	Protein conserved in bacteria
H1I74_RS10195	COG1132	(ABC) transporter
H1I74_RS10215	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H1I74_RS10220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H1I74_RS10230	COG0506	proline dehydrogenase activity
H1I74_RS10230	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H1I74_RS10230	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H1I74_RS10235	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H1I74_RS10250	COG3698	Phosphodiester glycosidase
H1I74_RS10260	COG2353	YceI-like domain
H1I74_RS10270	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H1I74_RS10315	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H1I74_RS10315	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H1I74_RS10340	COG3539	Fimbrial protein
H1I74_RS10345	COG3121	Chaperone
H1I74_RS10370	COG0697	spore germination
H1I74_RS10380	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H1I74_RS10390	COG0583	DNA-binding transcription factor activity
H1I74_RS10410	COG1309	transcriptional regulator
H1I74_RS10425	COG1522	sequence-specific DNA binding
H1I74_RS10435	COG1126	abc transporter atp-binding protein
H1I74_RS10440	COG0765	amino acid transport
H1I74_RS10445	COG0765	amino acid transport
H1I74_RS10475	COG1464	Belongs to the NlpA lipoprotein family
H1I74_RS10485	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H1I74_RS10490	COG2011	ABC-type metal ion transport system permease component
H1I74_RS10495	COG0012	GTP binding
H1I74_RS10520	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H1I74_RS10560	COG0386	Belongs to the glutathione peroxidase family
H1I74_RS10570	COG0436	Aminotransferase
H1I74_RS10610	COG3634	alkyl hydroperoxide reductase activity
H1I74_RS10625	COG0583	DNA-binding transcription factor activity
H1I74_RS10630	COG0798	PFAM Bile acid sodium symporter
H1I74_RS10635	COG0640	Transcriptional regulator
H1I74_RS10650	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H1I74_RS10660	COG0583	DNA-binding transcription factor activity
H1I74_RS10670	COG1953	Uracil, thiamine, allantoin
H1I74_RS10680	COG2175	clavaminate synthase activity
H1I74_RS10685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I74_RS10690	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H1I74_RS10695	COG4521	taurine ABC transporter
H1I74_RS10705	COG0477	Major facilitator Superfamily
H1I74_RS10725	COG1271	oxidase subunit
H1I74_RS10730	COG1294	oxidase, subunit
H1I74_RS10740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I74_RS10760	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H1I74_RS10780	COG3052	prosthetic group binding
H1I74_RS10785	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H1I74_RS10795	COG2814	Major facilitator Superfamily
H1I74_RS10815	COG1346	cytolysis
H1I74_RS10825	COG0583	DNA-binding transcription factor activity
H1I74_RS10830	COG0625	glutathione transferase activity
H1I74_RS10835	COG0625	glutathione transferase activity
H1I74_RS10840	COG0583	DNA-binding transcription factor activity
H1I74_RS10855	COG1045	serine acetyltransferase
H1I74_RS10860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1I74_RS10875	COG1280	lysine exporter protein (LysE YggA)
H1I74_RS10890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1I74_RS10895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1I74_RS10900	COG1126	abc transporter atp-binding protein
H1I74_RS10905	COG0765	amino acid transport
H1I74_RS10910	COG0765	amino acid transport
H1I74_RS10930	COG0784	Response regulator, receiver
H1I74_RS10930	COG2205	protein histidine kinase activity
H1I74_RS10950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H1I74_RS10970	COG1028	Short-chain dehydrogenase reductase Sdr
H1I74_RS11020	COG0583	DNA-binding transcription factor activity
H1I74_RS11040	COG0318	PFAM AMP-dependent synthetase and ligase
H1I74_RS11045	COG1309	transcriptional regulator
H1I74_RS11050	COG1960	acyl-CoA dehydrogenase activity
H1I74_RS11055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H1I74_RS11060	COG1024	Enoyl-CoA hydratase
H1I74_RS11065	COG4770	biotin carboxylase activity
H1I74_RS11075	COG0583	DNA-binding transcription factor activity
H1I74_RS11090	COG1960	acyl-CoA dehydrogenase activity
H1I74_RS11100	COG2814	Major facilitator Superfamily
H1I74_RS11110	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I74_RS11115	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H1I74_RS11120	COG2814	Major facilitator Superfamily
H1I74_RS11125	COG1960	acyl-CoA dehydrogenase activity
H1I74_RS11130	COG1024	Enoyl-CoA hydratase
H1I74_RS11135	COG1028	Short-chain dehydrogenase reductase Sdr
H1I74_RS11140	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1I74_RS11145	COG0183	Belongs to the thiolase family
H1I74_RS11155	COG2814	Major facilitator Superfamily
H1I74_RS11165	COG1024	Enoyl-CoA hydratase
H1I74_RS11180	COG1960	acyl-CoA dehydrogenase activity
H1I74_RS11185	COG2814	Major facilitator Superfamily
H1I74_RS11190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1I74_RS11195	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H1I74_RS11210	COG3842	ATPase activity
H1I74_RS11215	COG1840	ABC-type Fe3 transport system, periplasmic component
H1I74_RS11225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I74_RS11230	COG1414	Transcriptional regulator
H1I74_RS11240	COG0583	DNA-binding transcription factor activity
H1I74_RS11245	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H1I74_RS11250	COG1012	belongs to the aldehyde dehydrogenase family
H1I74_RS11260	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H1I74_RS11270	COG1012	belongs to the aldehyde dehydrogenase family
H1I74_RS11275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1I74_RS11280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I74_RS11285	COG2267	carboxylic ester hydrolase activity
H1I74_RS11305	COG3038	cytochrome b561
H1I74_RS11310	COG0753	catalase activity
H1I74_RS11345	COG2050	protein possibly involved in aromatic compounds catabolism
H1I74_RS11355	COG3327	negative regulation of DNA-templated transcription, initiation
H1I74_RS11360	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H1I74_RS11365	COG0183	Belongs to the thiolase family
H1I74_RS11370	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1I74_RS11375	COG1024	Enoyl-CoA hydratase
H1I74_RS11380	COG1024	Enoyl-CoA hydratase
H1I74_RS11385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I74_RS11390	COG2151	metal-sulfur cluster biosynthetic enzyme
H1I74_RS11395	COG3396	Phenylacetate-CoA oxygenase
H1I74_RS11400	COG3460	Phenylacetate-CoA oxygenase
H1I74_RS11405	COG3396	Phenylacetate-CoA oxygenase
H1I74_RS11410	COG2030	dehydratase
H1I74_RS11410	COG1012	belongs to the aldehyde dehydrogenase family
H1I74_RS11415	COG1760	l-serine dehydratase
H1I74_RS11420	COG0531	amino acid
H1I74_RS11425	COG1012	belongs to the aldehyde dehydrogenase family
H1I74_RS11440	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I74_RS11450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1I74_RS11470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I74_RS11480	COG0789	Transcriptional regulator
H1I74_RS11495	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H1I74_RS11510	COG2807	transmembrane transport
H1I74_RS11515	COG0590	tRNA wobble adenosine to inosine editing
H1I74_RS11630	COG1116	anion transmembrane transporter activity
H1I74_RS11635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1I74_RS11645	COG0864	Transcriptional regulator
H1I74_RS11665	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I74_RS11670	COG0439	Biotin carboxylase
H1I74_RS11685	COG1063	alcohol dehydrogenase
H1I74_RS11695	COG1309	transcriptional regulator
H1I74_RS11715	COG0038	chloride channel
H1I74_RS11720	COG4770	biotin carboxylase activity
H1I74_RS11740	COG1914	H( )-stimulated, divalent metal cation uptake system
H1I74_RS11745	COG0583	DNA-binding transcription factor activity
H1I74_RS11795	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1I74_RS11815	COG2814	Major facilitator Superfamily
H1I74_RS11825	COG1560	Kdo2-lipid A biosynthetic process
H1I74_RS11835	COG5006	permease, DMT superfamily
H1I74_RS11840	COG1522	sequence-specific DNA binding
H1I74_RS11855	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H1I74_RS11865	COG4122	O-methyltransferase activity
H1I74_RS11895	COG1538	Outer membrane efflux protein
H1I74_RS11900	COG1137	ATPase activity
H1I74_RS11905	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H1I74_RS11915	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H1I74_RS11920	COG0517	IMP dehydrogenase activity
H1I74_RS11920	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H1I74_RS11955	COG2814	Major facilitator Superfamily
H1I74_RS11990	COG1278	Cold shock
H1I74_RS11995	COG1280	lysine exporter protein (LysE YggA)
H1I74_RS12025	COG1570	exodeoxyribonuclease VII activity
H1I74_RS12075	COG0583	DNA-binding transcription factor activity
H1I74_RS12080	COG4638	Rieske (2fe-2S)
H1I74_RS12085	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H1I74_RS12090	COG0543	2 iron, 2 sulfur cluster binding
H1I74_RS12090	COG0633	Ferredoxin
H1I74_RS12095	COG1028	Short-chain dehydrogenase reductase Sdr
H1I74_RS12100	COG3135	benzoate transporter
H1I74_RS12105	COG2814	Major facilitator Superfamily
H1I74_RS12120	COG1643	Atp-dependent helicase
H1I74_RS12125	COG0450	alkyl hydroperoxide reductase
H1I74_RS12135	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H1I74_RS12145	COG3634	alkyl hydroperoxide reductase activity
H1I74_RS12165	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H1I74_RS12170	COG0625	glutathione transferase activity
H1I74_RS12180	COG2885	chlorophyll binding
H1I74_RS12215	COG0542	response to heat
H1I74_RS12230	COG1765	OsmC-like protein
H1I74_RS12250	COG0667	Aldo Keto reductase
H1I74_RS12265	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H1I74_RS12275	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H1I74_RS12285	COG0527	aspartate kinase activity
H1I74_RS12295	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H1I74_RS12305	COG3038	cytochrome b561
H1I74_RS12310	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H1I74_RS12315	COG2252	PERMEase
H1I74_RS12325	COG2072	flavoprotein involved in K transport
H1I74_RS12340	COG1741	Belongs to the pirin family
H1I74_RS12345	COG1309	transcriptional regulator
H1I74_RS12410	COG1902	pentaerythritol trinitrate reductase activity
H1I74_RS12410	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I74_RS12420	COG4251	negative regulation of phosphorylation
H1I74_RS12420	COG3706	GGDEF domain
H1I74_RS12420	COG2203	Gaf domain
H1I74_RS12420	COG5001	Diguanylate cyclase
H1I74_RS12430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1I74_RS12450	COG4172	Belongs to the ABC transporter superfamily
H1I74_RS12455	COG4239	(ABC) transporter, permease
H1I74_RS12460	COG4174	ABC transporter (Permease)
H1I74_RS12470	COG0741	lytic transglycosylase activity
H1I74_RS12470	COG1388	LysM domain
H1I74_RS12470	COG0741	lytic transglycosylase activity
H1I74_RS12470	COG1388	LysM domain
H1I74_RS12475	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1I74_RS12515	COG0583	DNA-binding transcription factor activity
H1I74_RS12520	COG1279	arginine transmembrane transporter activity
H1I74_RS12540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I74_RS12545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I74_RS12550	COG0006	proline dipeptidase activity
H1I74_RS12590	COG2194	sulfuric ester hydrolase activity
H1I74_RS12635	COG0739	heme binding
H1I74_RS12960	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H1I74_RS12985	COG3384	dioxygenase
H1I74_RS12995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H1I74_RS13000	COG2878	Part of a membrane complex involved in electron transport
H1I74_RS13005	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H1I74_RS13030	COG0768	penicillin binding
H1I74_RS13035	COG0742	ribosomal rna small subunit methyltransferase
H1I74_RS13050	COG0830	nickel cation binding
H1I74_RS13095	COG1253	flavin adenine dinucleotide binding
H1I74_RS13100	COG2851	Citrate transporter
H1I74_RS13155	COG1773	rubredoxin
H1I74_RS13160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I74_RS13170	COG0583	DNA-binding transcription factor activity
H1I74_RS13195	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H1I74_RS13200	COG4181	ATPase activity
H1I74_RS13245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H1I74_RS13265	COG0306	phosphate transporter
H1I74_RS13275	COG3958	Transketolase
H1I74_RS13280	COG3959	Transketolase, thiamine diphosphate binding domain
H1I74_RS13285	COG2271	Major facilitator Superfamily
H1I74_RS13290	COG1028	Short-chain dehydrogenase reductase Sdr
H1I74_RS13295	COG0583	DNA-binding transcription factor activity
H1I74_RS13310	COG2223	nitrite transmembrane transporter activity
H1I74_RS13315	COG2207	Transcriptional regulator
H1I74_RS13320	COG2066	Belongs to the glutaminase family
H1I74_RS13325	COG0242	peptide deformylase activity
H1I74_RS13330	COG0477	Major facilitator Superfamily
H1I74_RS13340	COG0028	Belongs to the TPP enzyme family
H1I74_RS13355	COG1028	Short-chain dehydrogenase reductase Sdr
H1I74_RS13360	COG2267	carboxylic ester hydrolase activity
H1I74_RS13370	COG2271	Major facilitator Superfamily
H1I74_RS13375	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I74_RS13385	COG1028	Short-chain dehydrogenase reductase Sdr
H1I74_RS13405	COG1414	Transcriptional regulator
H1I74_RS13420	COG1024	Enoyl-CoA hydratase
H1I74_RS13430	COG1215	transferase activity, transferring glycosyl groups
H1I74_RS13435	COG0726	polysaccharide deacetylase
H1I74_RS13435	COG1649	PFAM Uncharacterised BCR, COG1649
H1I74_RS13445	COG4681	YaeQ
H1I74_RS13455	COG0523	cobalamin synthesis protein
H1I74_RS13465	COG1607	acyl-coa hydrolase
H1I74_RS13475	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I74_RS13480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I74_RS13485	COG1309	transcriptional regulator
H1I74_RS13510	COG2040	homocysteine
H1I74_RS13515	COG0531	amino acid
H1I74_RS13570	COG1595	DNA-templated transcription, initiation
H1I74_RS13580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I74_RS13585	COG0477	Major facilitator Superfamily
H1I74_RS13605	COG0084	hydrolase, TatD family'
H1I74_RS13640	COG0629	single-stranded DNA binding
H1I74_RS13695	COG0582	viral genome integration into host DNA
H1I74_RS13795	COG0592	DNA-directed DNA polymerase activity
H1I74_RS13835	COG2026	Addiction module toxin, RelE StbE family
H1I74_RS14030	COG1484	DNA-dependent DNA replication
H1I74_RS14120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1I74_RS14190	COG0405	Gamma-glutamyltransferase
H1I74_RS14195	COG2814	Major facilitator Superfamily
H1I74_RS14205	COG2050	protein possibly involved in aromatic compounds catabolism
H1I74_RS14220	COG1090	epimerase
H1I74_RS14240	COG0420	3'-5' exonuclease activity
H1I74_RS14265	COG0735	belongs to the Fur family
H1I74_RS14270	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H1I74_RS14290	COG0121	glutamine amidotransferase
H1I74_RS14305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1I74_RS14315	COG0210	DNA helicase
H1I74_RS14320	COG2885	chlorophyll binding
H1I74_RS14325	COG0204	Acyl-transferase
H1I74_RS14340	COG2894	cell division
H1I74_RS14365	COG1280	lysine exporter protein (LysE YggA)
H1I74_RS14370	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H1I74_RS14370	COG1674	ftsk spoiiie
H1I74_RS14375	COG0492	ferredoxin-NADP+ reductase activity
H1I74_RS14380	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H1I74_RS14390	COG0456	acetyltransferase
H1I74_RS14435	COG1981	membrane
H1I74_RS14450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1I74_RS14450	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H1I74_RS14470	COG1012	belongs to the aldehyde dehydrogenase family
H1I74_RS14480	COG0657	acetylesterase activity
H1I74_RS14490	COG0473	3-isopropylmalate dehydrogenase activity
H1I74_RS14495	COG0583	DNA-binding transcription factor activity
H1I74_RS14515	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H1I74_RS14540	COG0564	pseudouridine synthase activity
H1I74_RS14550	COG0358	DNA primase activity
H1I74_RS14565	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H1I74_RS14595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H1I74_RS14625	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H1I74_RS14635	COG0351	phosphomethylpyrimidine kinase
H1I74_RS14635	COG0352	thiamine-phosphate diphosphorylase activity
H1I74_RS14635	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H1I74_RS14640	COG1652	LysM domain
H1I74_RS14665	COG1399	metal-binding, possibly nucleic acid-binding protein
H1I74_RS14670	COG3101	peptidyl-lysine hydroxylation
H1I74_RS14675	COG0009	L-threonylcarbamoyladenylate synthase
H1I74_RS14680	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H1I74_RS14685	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H1I74_RS14700	COG4106	trans-aconitate 2-methyltransferase activity
H1I74_RS14715	COG0596	Alpha beta hydrolase
H1I74_RS14715	COG2226	methyltransferase
H1I74_RS14715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1I74_RS14720	COG1877	trehalose-phosphatase activity
H1I74_RS14725	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H1I74_RS14730	COG2223	nitrite transmembrane transporter activity
H1I74_RS14750	COG1196	nuclear chromosome segregation
H1I74_RS14760	COG0730	response to heat
H1I74_RS14775	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H1I74_RS14785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H1I74_RS14835	COG0489	protein tyrosine kinase activity
H1I74_RS14845	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1I74_RS14845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1I74_RS14875	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H1I74_RS14880	COG2081	HI0933 family
H1I74_RS14890	COG0668	transmembrane transport
H1I74_RS14910	COG0583	DNA-binding transcription factor activity
H1I74_RS14930	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1I74_RS14935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H1I74_RS14965	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H1I74_RS15005	COG0745	RESPONSE REGULATOR receiver
H1I74_RS15025	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H1I74_RS15035	COG2205	protein histidine kinase activity
H1I74_RS15105	COG4993	Dehydrogenase
H1I74_RS15130	COG0384	phenazine biosynthesis protein PhzF
H1I74_RS15155	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I74_RS15170	COG0583	DNA-binding transcription factor activity
H1I74_RS15200	COG0583	DNA-binding transcription factor activity
H1I74_RS15215	COG0583	DNA-binding transcription factor activity
H1I74_RS15220	COG1053	succinate dehydrogenase
H1I74_RS15230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H1I74_RS15235	COG2814	Major facilitator Superfamily
H1I74_RS15240	COG1960	acyl-CoA dehydrogenase activity
H1I74_RS15245	COG0583	DNA-binding transcription factor activity
H1I74_RS15250	COG1063	alcohol dehydrogenase
H1I74_RS15280	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H1I74_RS15285	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H1I74_RS15290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H1I74_RS15305	COG3667	copper resistance
H1I74_RS15310	COG2132	Multicopper oxidase
H1I74_RS15320	COG0561	phosphatase activity
H1I74_RS15325	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H1I74_RS15350	COG1214	PFAM Peptidase M22, glycoprotease
H1I74_RS15400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H1I74_RS15410	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H1I74_RS15415	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H1I74_RS15420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H1I74_RS15480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1I74_RS15490	COG1846	Transcriptional regulator
H1I74_RS15495	COG1764	response to oxidative stress
H1I74_RS15545	COG0037	tRNA processing
H1I74_RS15555	COG0248	Ppx GppA phosphatase
H1I74_RS15585	COG0072	phenylalanine-tRNA ligase activity
H1I74_RS15625	COG1238	metal cluster binding
H1I74_RS15630	COG0625	glutathione transferase activity
H1I74_RS15645	COG0318	PFAM AMP-dependent synthetase and ligase
H1I74_RS15650	COG3028	Belongs to the UPF0307 family
H1I74_RS15655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1I74_RS15675	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H1I74_RS15680	COG0617	tRNA 3'-terminal CCA addition
H1I74_RS15685	COG1555	photosystem II stabilization
H1I74_RS15690	COG3956	TIGRFAM MazG family protein
H1I74_RS15700	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H1I74_RS15720	COG0784	Response regulator, receiver
H1I74_RS15720	COG2205	protein histidine kinase activity
H1I74_RS15720	COG5002	protein histidine kinase activity
H1I74_RS15725	COG1024	Enoyl-CoA hydratase
H1I74_RS15730	COG2084	Dehydrogenase
H1I74_RS15735	COG3622	Belongs to the hyi family
H1I74_RS15765	COG0697	spore germination
H1I74_RS15775	COG2814	Major facilitator Superfamily
H1I74_RS15780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H1I74_RS15790	COG0583	DNA-binding transcription factor activity
H1I74_RS15800	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H1I74_RS15815	COG0084	hydrolase, TatD family'
H1I74_RS15830	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H1I74_RS15860	COG0440	acetolactate synthase activity
H1I74_RS15865	COG0028	Belongs to the TPP enzyme family
H1I74_RS15890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I74_RS15895	COG0577	efflux transmembrane transporter activity
H1I74_RS15895	COG1136	(ABC) transporter
H1I74_RS15900	COG1538	Outer membrane efflux protein
H1I74_RS15915	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H1I74_RS15920	COG1162	GTPase activity
H1I74_RS15930	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H1I74_RS15950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H1I74_RS15955	COG1028	Short-chain dehydrogenase reductase Sdr
H1I74_RS15995	COG2986	histidine ammonia-lyase
H1I74_RS16010	COG0318	PFAM AMP-dependent synthetase and ligase
H1I74_RS16020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1I74_RS16065	COG1426	Protein conserved in bacteria
H1I74_RS16100	COG0793	Belongs to the peptidase S41A family
H1I74_RS16115	COG2267	carboxylic ester hydrolase activity
H1I74_RS16125	COG1012	belongs to the aldehyde dehydrogenase family
H1I74_RS16130	COG3265	gluconokinase activity
H1I74_RS16140	COG0800	Aldolase
H1I74_RS16155	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H1I74_RS16160	COG0857	belongs to the CobB CobQ family
H1I74_RS16160	COG0280	phosphate acetyltransferase
H1I74_RS16165	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H1I74_RS16165	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H1I74_RS16185	COG0740	serine-type endopeptidase activity
H1I74_RS16195	COG4774	siderophore transport
H1I74_RS16205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H1I74_RS16215	COG2813	Specifically methylates the guanine in position
H1I74_RS16215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1I74_RS16315	COG0788	formyltetrahydrofolate deformylase activity
H1I74_RS16340	COG4651	solute:proton antiporter activity
H1I74_RS16340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1I74_RS16360	COG0724	RNA recognition motif
H1I74_RS16365	COG0210	DNA helicase
H1I74_RS16390	COG1733	regulation of RNA biosynthetic process
H1I74_RS16400	COG2900	Belongs to the SlyX family
H1I74_RS16405	COG0488	(ABC) transporter
H1I74_RS16410	COG1280	lysine exporter protein (LysE YggA)
H1I74_RS16415	COG1560	Kdo2-lipid A biosynthetic process
H1I74_RS16425	COG1301	dicarboxylic acid transport
H1I74_RS16480	COG0473	3-isopropylmalate dehydrogenase activity
H1I74_RS16545	COG0583	DNA-binding transcription factor activity
H1I74_RS16555	COG0625	glutathione transferase activity
H1I74_RS16560	COG2378	regulation of single-species biofilm formation
H1I74_RS16565	COG0546	phosphoglycolate phosphatase activity
H1I74_RS16575	COG1530	ribonuclease E activity
H1I74_RS16580	COG0318	PFAM AMP-dependent synthetase and ligase
H1I74_RS16595	COG0583	DNA-binding transcription factor activity
H1I74_RS16600	COG4221	oxidoreductase activity
H1I74_RS16605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H1I74_RS16615	COG0534	Mate efflux family protein
H1I74_RS16630	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H1I74_RS16670	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H1I74_RS16675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1I74_RS16690	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H1I74_RS16700	COG0644	oxidoreductase
H1I74_RS16700	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H1I74_RS16705	COG0425	Belongs to the sulfur carrier protein TusA family
H1I74_RS16710	COG4535	Mg2 and Co2 transporter CorC
H1I74_RS16720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1I74_RS16740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H1I74_RS16745	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1I74_RS16745	COG0475	glutathione-regulated potassium exporter activity
H1I74_RS16750	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H1I74_RS16760	COG0484	heat shock protein binding
H1I74_RS16765	COG0789	Transcriptional regulator
H1I74_RS16770	COG0598	Magnesium transport protein CorA
H1I74_RS16785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H1I74_RS16790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1I74_RS16795	COG1074	ATP-dependent DNA helicase activity
H1I74_RS16800	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H1I74_RS16820	COG2226	methyltransferase
H1I74_RS16835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I74_RS16840	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H1I74_RS16855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H1I74_RS16855	COG2111	Na H antiporter
H1I74_RS16860	COG1006	Multisubunit Na H antiporter MnhC subunit
H1I74_RS16865	COG0651	ATP synthesis coupled electron transport
H1I74_RS16870	COG1863	multisubunit Na H antiporter MnhE subunit
H1I74_RS16875	COG2212	antiporter activity
H1I74_RS16880	COG1320	monovalent cation:proton antiporter activity
H1I74_RS16895	COG0195	Participates in both transcription termination and antitermination
H1I74_RS16945	COG0237	dephospho-CoA kinase activity
H1I74_RS16955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1I74_RS16970	COG0497	DNA recombination
H1I74_RS16980	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H1I74_RS17010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H1I74_RS17010	COG2169	Transcriptional regulator
H1I74_RS17015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H1I74_RS17080	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H1I74_RS17095	COG0326	Molecular chaperone. Has ATPase activity
H1I74_RS17110	COG2056	Na+-H+ antiporter family
H1I74_RS17115	COG0596	Alpha beta hydrolase
H1I74_RS17210	COG0546	phosphoglycolate phosphatase activity
H1I74_RS17215	COG1716	ATPase activity
H1I74_RS17260	COG0181	hydroxymethylbilane synthase activity
H1I74_RS17270	COG3275	phosphorelay sensor kinase activity
H1I74_RS17290	COG1538	Outer membrane efflux protein
H1I74_RS17295	COG0697	spore germination
H1I74_RS17320	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H1I74_RS17325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H1I74_RS17330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1I74_RS17335	COG0772	Belongs to the SEDS family
H1I74_RS17360	COG4974	Belongs to the 'phage' integrase family
H1I74_RS17365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1I74_RS17375	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H1I74_RS17385	COG2197	response regulator
H1I74_RS17400	COG0793	Belongs to the peptidase S41A family
H1I74_RS17405	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H1I74_RS17410	COG0795	lipopolysaccharide-transporting ATPase activity
H1I74_RS17450	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1I74_RS17450	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1I74_RS17460	COG0004	ammonium transporteR
H1I74_RS17465	COG0347	Belongs to the P(II) protein family
H1I74_RS17475	COG0606	chelatase, subunit chli
H1I74_RS17555	COG0659	secondary active sulfate transmembrane transporter activity
H1I74_RS17560	COG0589	response to stress
H1I74_RS17600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1I74_RS17645	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H1I74_RS17675	COG0659	secondary active sulfate transmembrane transporter activity
H1I74_RS17680	COG0589	response to stress
H1I74_RS17710	COG0606	chelatase, subunit chli
H1I74_RS17725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I74_RS17740	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H1I74_RS17755	COG0318	PFAM AMP-dependent synthetase and ligase
H1I74_RS17765	COG0477	Major facilitator Superfamily
H1I74_RS17770	COG2860	membrane
H1I74_RS17780	COG1253	flavin adenine dinucleotide binding
H1I74_RS17800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H1I74_RS17835	COG0655	NAD(P)H dehydrogenase (quinone) activity
H1I74_RS17845	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H1I74_RS17880	COG1309	transcriptional regulator
H1I74_RS17915	COG0758	DNA mediated transformation
H1I74_RS17925	COG0697	spore germination
H1I74_RS17930	COG1309	transcriptional regulator
H1I74_RS17945	COG0386	Belongs to the glutathione peroxidase family
H1I74_RS18010	COG1121	(ABC) transporter
H1I74_RS18015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H1I74_RS18020	COG1280	lysine exporter protein (LysE YggA)
H1I74_RS18025	COG2837	iron assimilation
H1I74_RS18035	COG0281	malic enzyme
H1I74_RS18080	COG0519	Catalyzes the synthesis of GMP from XMP
H1I74_RS18080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H1I74_RS18085	COG4399	Belongs to the UPF0754 family
H1I74_RS18090	COG2259	Doxx family
H1I74_RS18095	COG0586	Pfam SNARE associated Golgi protein
H1I74_RS18110	COG1192	Involved in chromosome partitioning
H1I74_RS18120	COG0271	Belongs to the BolA IbaG family
H1I74_RS18140	COG2267	carboxylic ester hydrolase activity
H1I74_RS18160	COG3321	synthase
H1I74_RS18160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1I74_RS18160	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H1I74_RS18160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H1I74_RS18165	COG1960	acyl-CoA dehydrogenase activity
H1I74_RS18175	COG2197	response regulator
H1I74_RS18185	COG3916	Acyl-homoserine-lactone synthase
H1I74_RS18190	COG0477	Major facilitator Superfamily
H1I74_RS18195	COG1024	Enoyl-CoA hydratase
H1I74_RS18200	COG1024	Enoyl-CoA hydratase
H1I74_RS18205	COG1960	acyl-CoA dehydrogenase activity
H1I74_RS18210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1I74_RS18230	COG1113	amino acid transport
H1I74_RS18235	COG1113	amino acid transport
H1I74_RS18240	COG0251	oxidation-reduction process
H1I74_RS18280	COG0564	pseudouridine synthase activity
H1I74_RS18340	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H1I74_RS18355	COG1802	Transcriptional regulator
H1I74_RS18365	COG1448	Aminotransferase
H1I74_RS18370	COG0277	FAD linked oxidase domain protein
H1I74_RS18380	COG2186	Transcriptional regulator
H1I74_RS18390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1I74_RS18395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H1I74_RS18410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H1I74_RS18415	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H1I74_RS18420	COG1216	Glycosyl transferase, family 2
H1I74_RS18450	COG2089	acid synthase
H1I74_RS18465	COG1083	cytidylyl-transferase
H1I74_RS18470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H1I74_RS18475	COG1086	Polysaccharide biosynthesis protein
H1I74_RS18480	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H1I74_RS18485	COG1596	polysaccharide export
H1I74_RS18510	COG0728	peptidoglycan biosynthetic process
H1I74_RS18515	COG3023	N-Acetylmuramoyl-L-alanine amidase
H1I74_RS18570	COG0546	phosphoglycolate phosphatase activity
H1I74_RS18575	COG1028	Short-chain dehydrogenase reductase Sdr
H1I74_RS18595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I74_RS18600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I74_RS18605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1I74_RS18610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I74_RS18615	COG1116	anion transmembrane transporter activity
H1I74_RS18620	COG1309	transcriptional regulator
H1I74_RS18625	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H1I74_RS18635	COG0196	riboflavin kinase activity
H1I74_RS18640	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H1I74_RS18650	COG1047	Peptidyl-prolyl cis-trans
H1I74_RS18690	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H1I74_RS18695	COG0657	acetylesterase activity
H1I74_RS18745	COG2951	lytic endotransglycosylase activity
H1I74_RS18750	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H1I74_RS18765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H1I74_RS18775	COG0671	phosphoesterase, PA-phosphatase related
H1I74_RS18780	COG0861	Integral membrane protein TerC family
H1I74_RS18790	COG0754	glutathionylspermidine amidase activity
H1I74_RS18800	COG0402	S-adenosylhomocysteine deaminase activity
H1I74_RS18815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1I74_RS18820	COG1230	cation diffusion facilitator family transporter
H1I74_RS18835	COG0706	membrane insertase activity