locus-tag	class	description
N4T37_RS00060	COG3173	Aminoglycoside phosphotransferase
N4T37_RS00065	COG0488	(ABC) transporter
N4T37_RS00085	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N4T37_RS00090	COG3657	addiction module killer protein
N4T37_RS00095	COG2826	transposase and inactivated derivatives, IS30 family
N4T37_RS00125	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
N4T37_RS00150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N4T37_RS00160	COG2814	Major facilitator Superfamily
N4T37_RS00185	COG0657	acetylesterase activity
N4T37_RS00310	COG4974	Belongs to the 'phage' integrase family
N4T37_RS00425	COG1475	DNA binding
N4T37_RS00430	COG1192	Involved in chromosome partitioning
N4T37_RS00540	COG0789	Transcriptional regulator
N4T37_RS00550	COG0640	Transcriptional regulator
N4T37_RS00560	COG1230	cation diffusion facilitator family transporter
N4T37_RS00565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N4T37_RS00835	COG4372	Transposase
N4T37_RS00845	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N4T37_RS00870	COG2963	transposase activity
N4T37_RS00880	COG4372	Transposase
N4T37_RS00895	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
N4T37_RS00915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N4T37_RS00925	COG5002	protein histidine kinase activity
N4T37_RS00930	COG0745	RESPONSE REGULATOR receiver
N4T37_RS00960	COG0860	N-Acetylmuramoyl-L-alanine amidase
N4T37_RS00985	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N4T37_RS01010	COG4372	Transposase
N4T37_RS01090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N4T37_RS01150	COG4372	Transposase
N4T37_RS01170	COG2189	Belongs to the N(4) N(6)-methyltransferase family
N4T37_RS01180	COG1525	nuclease
N4T37_RS01235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N4T37_RS01355	COG2826	transposase and inactivated derivatives, IS30 family
N4T37_RS01435	COG2826	transposase and inactivated derivatives, IS30 family
N4T37_RS01510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N4T37_RS01710	COG5410	chromosome segregation
N4T37_RS01800	COG0305	Participates in initiation and elongation during chromosome replication
N4T37_RS01830	COG3620	sequence-specific DNA binding
N4T37_RS01860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N4T37_RS01895	COG0582	viral genome integration into host DNA
N4T37_RS01975	COG0739	heme binding
N4T37_RS01985	COG3561	AntA/AntB antirepressor
N4T37_RS02100	COG5410	chromosome segregation
N4T37_RS02260	COG0527	aspartate kinase activity
N4T37_RS02270	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N4T37_RS02280	COG3038	cytochrome b561
N4T37_RS02285	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N4T37_RS02290	COG2252	PERMEase
N4T37_RS02300	COG2072	flavoprotein involved in K transport
N4T37_RS02315	COG1741	Belongs to the pirin family
N4T37_RS02320	COG1309	transcriptional regulator
N4T37_RS02330	COG0300	oxidoreductase activity
N4T37_RS02340	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
N4T37_RS02385	COG1262	PFAM Formylglycine-generating sulfatase enzyme
N4T37_RS02400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N4T37_RS02450	COG0446	pyridine nucleotide-disulphide oxidoreductase
N4T37_RS02450	COG1902	pentaerythritol trinitrate reductase activity
N4T37_RS02470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N4T37_RS02490	COG4172	Belongs to the ABC transporter superfamily
N4T37_RS02495	COG4239	(ABC) transporter, permease
N4T37_RS02500	COG4174	ABC transporter (Permease)
N4T37_RS02510	COG1388	LysM domain
N4T37_RS02510	COG0741	lytic transglycosylase activity
N4T37_RS02510	COG0741	lytic transglycosylase activity
N4T37_RS02510	COG1388	LysM domain
N4T37_RS02515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N4T37_RS02570	COG0583	DNA-binding transcription factor activity
N4T37_RS02575	COG1279	arginine transmembrane transporter activity
N4T37_RS02595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N4T37_RS02600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N4T37_RS02605	COG0006	proline dipeptidase activity
N4T37_RS02645	COG2194	sulfuric ester hydrolase activity
N4T37_RS02690	COG1196	nuclear chromosome segregation
N4T37_RS02690	COG0741	lytic transglycosylase activity
N4T37_RS02690	COG0739	heme binding
N4T37_RS02800	COG5410	chromosome segregation
N4T37_RS02985	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N4T37_RS03015	COG3384	dioxygenase
N4T37_RS03025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N4T37_RS03030	COG2878	Part of a membrane complex involved in electron transport
N4T37_RS03035	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N4T37_RS03060	COG0768	penicillin binding
N4T37_RS03065	COG0742	ribosomal rna small subunit methyltransferase
N4T37_RS03080	COG0830	nickel cation binding
N4T37_RS03090	COG0804	urea catabolic process
N4T37_RS03135	COG1253	flavin adenine dinucleotide binding
N4T37_RS03140	COG2851	Citrate transporter
N4T37_RS03195	COG1773	rubredoxin
N4T37_RS03200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N4T37_RS03210	COG0583	DNA-binding transcription factor activity
N4T37_RS03245	COG4181	ATPase activity
N4T37_RS03290	COG1262	PFAM Formylglycine-generating sulfatase enzyme
N4T37_RS03310	COG0306	phosphate transporter
N4T37_RS03320	COG3958	Transketolase
N4T37_RS03325	COG3959	Transketolase, thiamine diphosphate binding domain
N4T37_RS03330	COG2271	Major facilitator Superfamily
N4T37_RS03335	COG1028	Short-chain dehydrogenase reductase Sdr
N4T37_RS03340	COG0583	DNA-binding transcription factor activity
N4T37_RS03355	COG2223	nitrite transmembrane transporter activity
N4T37_RS03360	COG2207	Transcriptional regulator
N4T37_RS03365	COG2066	Belongs to the glutaminase family
N4T37_RS03370	COG0242	peptide deformylase activity
N4T37_RS03375	COG0477	Major facilitator Superfamily
N4T37_RS03385	COG0028	Belongs to the TPP enzyme family
N4T37_RS03400	COG1028	Short-chain dehydrogenase reductase Sdr
N4T37_RS03405	COG2267	carboxylic ester hydrolase activity
N4T37_RS03415	COG2271	Major facilitator Superfamily
N4T37_RS03430	COG1028	Short-chain dehydrogenase reductase Sdr
N4T37_RS03450	COG1414	Transcriptional regulator
N4T37_RS03465	COG1024	Enoyl-CoA hydratase
N4T37_RS03475	COG1215	transferase activity, transferring glycosyl groups
N4T37_RS03480	COG1649	PFAM Uncharacterised BCR, COG1649
N4T37_RS03480	COG0726	polysaccharide deacetylase
N4T37_RS03490	COG4681	YaeQ
N4T37_RS03500	COG0523	cobalamin synthesis protein
N4T37_RS03510	COG1607	acyl-coa hydrolase
N4T37_RS03520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N4T37_RS03525	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N4T37_RS03530	COG1309	transcriptional regulator
N4T37_RS03560	COG0531	amino acid
N4T37_RS03615	COG1595	DNA-templated transcription, initiation
N4T37_RS03625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N4T37_RS03630	COG0477	Major facilitator Superfamily
N4T37_RS03640	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
N4T37_RS03710	COG0405	Gamma-glutamyltransferase
N4T37_RS03715	COG2814	Major facilitator Superfamily
N4T37_RS03725	COG2050	protein possibly involved in aromatic compounds catabolism
N4T37_RS03740	COG1090	epimerase
N4T37_RS03760	COG0420	3'-5' exonuclease activity
N4T37_RS03785	COG0735	belongs to the Fur family
N4T37_RS03790	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N4T37_RS03810	COG0121	glutamine amidotransferase
N4T37_RS03825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N4T37_RS03835	COG0210	DNA helicase
N4T37_RS03840	COG2885	chlorophyll binding
N4T37_RS03845	COG0204	Acyl-transferase
N4T37_RS03860	COG2894	cell division
N4T37_RS03875	COG1280	lysine exporter protein (LysE YggA)
N4T37_RS03880	COG1674	ftsk spoiiie
N4T37_RS03885	COG0492	ferredoxin-NADP+ reductase activity
N4T37_RS03890	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
N4T37_RS03900	COG0456	acetyltransferase
N4T37_RS03945	COG1981	membrane
N4T37_RS03960	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N4T37_RS03960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N4T37_RS03980	COG1012	belongs to the aldehyde dehydrogenase family
N4T37_RS03990	COG0657	acetylesterase activity
N4T37_RS04000	COG0473	3-isopropylmalate dehydrogenase activity
N4T37_RS04005	COG0583	DNA-binding transcription factor activity
N4T37_RS04025	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N4T37_RS04035	COG0582	viral genome integration into host DNA
N4T37_RS04115	COG0739	heme binding
N4T37_RS04125	COG3561	AntA/AntB antirepressor
N4T37_RS04255	COG5410	chromosome segregation
N4T37_RS04345	COG0305	Participates in initiation and elongation during chromosome replication
N4T37_RS04375	COG3620	sequence-specific DNA binding
N4T37_RS04405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N4T37_RS04455	COG0564	pseudouridine synthase activity
N4T37_RS04465	COG0358	DNA primase activity
N4T37_RS04480	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
N4T37_RS04510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N4T37_RS04540	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N4T37_RS04550	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
N4T37_RS04550	COG0351	phosphomethylpyrimidine kinase
N4T37_RS04550	COG0352	thiamine-phosphate diphosphorylase activity
N4T37_RS04555	COG1652	LysM domain
N4T37_RS04580	COG1399	metal-binding, possibly nucleic acid-binding protein
N4T37_RS04585	COG3101	peptidyl-lysine hydroxylation
N4T37_RS04590	COG0009	L-threonylcarbamoyladenylate synthase
N4T37_RS04595	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
N4T37_RS04600	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
N4T37_RS04615	COG4106	trans-aconitate 2-methyltransferase activity
N4T37_RS04630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N4T37_RS04630	COG0596	Alpha beta hydrolase
N4T37_RS04630	COG2226	methyltransferase
N4T37_RS04635	COG1877	trehalose-phosphatase activity
N4T37_RS04640	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
N4T37_RS04645	COG2223	nitrite transmembrane transporter activity
N4T37_RS04665	COG1196	nuclear chromosome segregation
N4T37_RS04675	COG0730	response to heat
N4T37_RS04690	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N4T37_RS04700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N4T37_RS04755	COG2826	transposase and inactivated derivatives, IS30 family
N4T37_RS04780	COG0464	growth
N4T37_RS04800	COG2207	Transcriptional regulator
N4T37_RS04825	COG2249	NAD(P)H dehydrogenase (quinone) activity
N4T37_RS04835	COG0560	Phosphoserine phosphatase
N4T37_RS04845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N4T37_RS04855	COG1530	ribonuclease E activity
N4T37_RS04860	COG0424	maF-like protein
N4T37_RS04865	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
N4T37_RS04870	COG1792	Involved in formation and maintenance of cell shape
N4T37_RS04875	COG1077	Cell shape determining protein MreB Mrl
N4T37_RS04880	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N4T37_RS04890	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N4T37_RS04915	COG3590	peptidase
N4T37_RS04920	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
N4T37_RS04925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N4T37_RS04930	COG1752	Esterase of the alpha-beta hydrolase superfamily
N4T37_RS04935	COG1115	amino acid carrier protein
N4T37_RS04955	COG2814	Major facilitator Superfamily
N4T37_RS04960	COG1289	transmembrane transporter activity
N4T37_RS04970	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
N4T37_RS05010	COG1376	ErfK ybiS ycfS ynhG family protein
N4T37_RS05015	COG2832	Protein of unknown function (DUF454)
N4T37_RS05025	COG5510	response to toxic substance
N4T37_RS05045	COG0840	transmembrane signaling receptor activity
N4T37_RS05085	COG3422	double-strand break repair
N4T37_RS05090	COG2824	Alkylphosphonate utilization operon protein PhnA
N4T37_RS05095	COG3189	MarR family transcriptional regulator
N4T37_RS05105	COG0354	folic acid binding
N4T37_RS05110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N4T37_RS05120	COG0679	Auxin Efflux Carrier
N4T37_RS05125	COG1902	pentaerythritol trinitrate reductase activity
N4T37_RS05130	COG4772	TonB-dependent receptor
N4T37_RS05135	COG2094	Belongs to the DNA glycosylase MPG family
N4T37_RS05160	COG1217	gtp-binding protein TYPA
N4T37_RS05165	COG2233	PERMEase
N4T37_RS05175	COG0833	amino acid
N4T37_RS05180	COG1690	Belongs to the RtcB family
N4T37_RS05190	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
N4T37_RS05190	COG2885	chlorophyll binding
N4T37_RS05200	COG0183	Belongs to the thiolase family
N4T37_RS05220	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N4T37_RS05240	COG2207	Transcriptional regulator
N4T37_RS05245	COG0183	Belongs to the thiolase family
N4T37_RS05275	COG1272	protein, Hemolysin III
N4T37_RS05280	COG0477	Major facilitator Superfamily
N4T37_RS05295	COG0450	alkyl hydroperoxide reductase
N4T37_RS05315	COG0285	dihydrofolate synthase activity
N4T37_RS05360	COG4206	TonB-dependent receptor
N4T37_RS05365	COG2096	Adenosyltransferase
N4T37_RS05370	COG0584	glycerophosphoryl diester phosphodiesterase
N4T37_RS05385	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
N4T37_RS05390	COG0745	RESPONSE REGULATOR receiver
N4T37_RS05395	COG2205	protein histidine kinase activity
N4T37_RS05405	COG1960	acyl-CoA dehydrogenase activity
N4T37_RS05410	COG1960	acyl-CoA dehydrogenase activity
N4T37_RS05470	COG2826	transposase and inactivated derivatives, IS30 family
N4T37_RS05495	COG0438	transferase activity, transferring glycosyl groups
N4T37_RS05500	COG0463	Glycosyl transferase, family 2
N4T37_RS05505	COG0726	polysaccharide deacetylase
N4T37_RS05525	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N4T37_RS05585	COG1862	Preprotein translocase
N4T37_RS05595	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N4T37_RS05600	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N4T37_RS05610	COG3781	membrane
N4T37_RS05615	COG0613	PHP domain protein
N4T37_RS05625	COG2350	Protein conserved in bacteria
N4T37_RS05655	COG1607	acyl-coa hydrolase
N4T37_RS05715	COG2199	diguanylate cyclase activity
N4T37_RS05725	COG1408	metallophosphoesterase
N4T37_RS05730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N4T37_RS05740	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N4T37_RS05760	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N4T37_RS05765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N4T37_RS05780	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N4T37_RS05790	COG2969	positive regulation of protein catabolic process
N4T37_RS05810	COG1960	acyl-CoA dehydrogenase activity
N4T37_RS05815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N4T37_RS05830	COG1309	transcriptional regulator
N4T37_RS05835	COG1960	acyl-CoA dehydrogenase activity
N4T37_RS05880	COG1183	phosphatidylcholine synthase activity
N4T37_RS05885	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
N4T37_RS05915	COG0739	heme binding
N4T37_RS05915	COG0741	lytic transglycosylase activity
N4T37_RS05915	COG1196	nuclear chromosome segregation
N4T37_RS05925	COG1702	phosphate starvation-inducible protein PhoH
N4T37_RS05960	COG1295	ribonuclease BN
N4T37_RS05965	COG0697	spore germination
N4T37_RS05975	COG0179	Fumarylacetoacetate (FAA) hydrolase
N4T37_RS06020	COG0557	exoribonuclease II activity
N4T37_RS06025	COG0339	signal peptide processing
N4T37_RS06030	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
N4T37_RS06060	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
N4T37_RS06065	COG1960	acyl-CoA dehydrogenase activity
N4T37_RS06220	COG0626	cystathionine gamma-synthase activity
N4T37_RS06225	COG0433	COG0433 Predicted ATPase
N4T37_RS06235	COG1017	nitric oxide dioxygenase activity
N4T37_RS06235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N4T37_RS06240	COG1959	2 iron, 2 sulfur cluster binding
N4T37_RS06255	COG1301	dicarboxylic acid transport
N4T37_RS06260	COG1946	Acyl-CoA thioesterase
N4T37_RS06280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N4T37_RS06285	COG1040	competence protein
N4T37_RS06290	COG0494	nUDIX hydrolase
N4T37_RS06300	COG0598	Magnesium transport protein CorA
N4T37_RS06310	COG2854	intermembrane phospholipid transfer
N4T37_RS06320	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N4T37_RS06325	COG1127	ABC transporter
N4T37_RS06335	COG0513	Belongs to the DEAD box helicase family
N4T37_RS06355	COG0408	coproporphyrinogen oxidase activity
N4T37_RS06370	COG1960	acyl-CoA dehydrogenase activity
N4T37_RS06380	COG1983	PspC domain protein
N4T37_RS06385	COG0517	IMP dehydrogenase activity
N4T37_RS06420	COG1106	Psort location Cytoplasmic, score
N4T37_RS06440	COG0583	DNA-binding transcription factor activity
N4T37_RS06480	COG1012	belongs to the aldehyde dehydrogenase family
N4T37_RS06490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N4T37_RS06495	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N4T37_RS06500	COG0833	amino acid
N4T37_RS06530	COG1192	Involved in chromosome partitioning
N4T37_RS06535	COG0628	permease
N4T37_RS06545	COG1289	transmembrane transporter activity
N4T37_RS06555	COG4372	Transposase
N4T37_RS06580	COG2249	NAD(P)H dehydrogenase (quinone) activity
N4T37_RS06585	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
N4T37_RS06600	COG0277	FAD linked oxidase domain protein
N4T37_RS06605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N4T37_RS06630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N4T37_RS06635	COG5380	lipid catabolic process
N4T37_RS06655	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N4T37_RS06705	COG0194	GDP metabolic process
N4T37_RS06720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N4T37_RS06740	COG3307	-O-antigen
N4T37_RS06760	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
N4T37_RS06765	COG1704	LemA family
N4T37_RS06775	COG0493	'glutamate synthase
N4T37_RS06780	COG0067	glutamate synthase
N4T37_RS06780	COG0069	glutamate synthase activity
N4T37_RS06780	COG0070	glutamate synthase
N4T37_RS06830	COG2226	methyltransferase
N4T37_RS06845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N4T37_RS06850	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N4T37_RS06895	COG0833	amino acid
N4T37_RS06960	COG0488	(ABC) transporter
N4T37_RS06970	COG4221	oxidoreductase activity
N4T37_RS06975	COG0659	secondary active sulfate transmembrane transporter activity
N4T37_RS07000	COG0427	acetyl-CoA hydrolase
N4T37_RS07030	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N4T37_RS07060	COG2329	Antibiotic biosynthesis monooxygenase
N4T37_RS07075	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N4T37_RS07140	COG2249	NAD(P)H dehydrogenase (quinone) activity
N4T37_RS07145	COG1733	regulation of RNA biosynthetic process
N4T37_RS07180	COG0667	Aldo Keto reductase
N4T37_RS07200	COG0583	DNA-binding transcription factor activity
N4T37_RS07205	COG2814	Major facilitator Superfamily
N4T37_RS07215	COG1113	amino acid transport
N4T37_RS07220	COG4372	Transposase
N4T37_RS07250	COG2508	Transcriptional regulator
N4T37_RS07250	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
N4T37_RS07285	COG1335	isochorismatase
N4T37_RS07295	COG1012	belongs to the aldehyde dehydrogenase family
N4T37_RS07300	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N4T37_RS07310	COG1113	amino acid transport
N4T37_RS07320	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
N4T37_RS07335	COG2814	Major facilitator Superfamily
N4T37_RS07345	COG0352	thiamine-phosphate diphosphorylase activity
N4T37_RS07345	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
N4T37_RS07345	COG0351	phosphomethylpyrimidine kinase
N4T37_RS07365	COG1309	transcriptional regulator
N4T37_RS07370	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N4T37_RS07395	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N4T37_RS07400	COG3162	membrane
N4T37_RS07405	COG2205	protein histidine kinase activity
N4T37_RS07405	COG2198	Histidine kinase
N4T37_RS07405	COG0784	Response regulator, receiver
N4T37_RS07430	COG1522	sequence-specific DNA binding
N4T37_RS07435	COG1335	isochorismatase
N4T37_RS07440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N4T37_RS07450	COG0668	transmembrane transport
N4T37_RS07455	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N4T37_RS07465	COG1902	pentaerythritol trinitrate reductase activity
N4T37_RS07485	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N4T37_RS07510	COG0426	domain, Protein
N4T37_RS07510	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N4T37_RS07515	COG4774	siderophore transport
N4T37_RS07520	COG2119	membrane
N4T37_RS07530	COG0508	dehydrogenase complex catalyzes the overall conversion of
N4T37_RS07540	COG4942	peptidase
N4T37_RS07555	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N4T37_RS07565	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N4T37_RS07585	COG0189	ligase activity
N4T37_RS07605	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N4T37_RS07620	COG0708	Exodeoxyribonuclease III
N4T37_RS07625	COG1393	Belongs to the ArsC family
N4T37_RS07640	COG3706	GGDEF domain
N4T37_RS07675	COG2351	hydroxyisourate hydrolase activity
N4T37_RS07680	COG2233	PERMEase
N4T37_RS07690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N4T37_RS07700	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
N4T37_RS07710	COG3150	esterase
N4T37_RS07755	COG2918	glutathione biosynthetic process
N4T37_RS07770	COG2733	membrane
N4T37_RS07775	COG0436	Aminotransferase
N4T37_RS07780	COG0534	Mate efflux family protein
N4T37_RS07865	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
N4T37_RS07870	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
N4T37_RS07880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N4T37_RS07885	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N4T37_RS07900	COG0010	Belongs to the arginase family
N4T37_RS07930	COG2188	Transcriptional regulator
N4T37_RS07940	COG0523	cobalamin synthesis protein
N4T37_RS07950	COG1113	amino acid transport
N4T37_RS07960	COG0625	glutathione transferase activity
N4T37_RS07980	COG1683	Conserved Protein
N4T37_RS07985	COG0534	Mate efflux family protein
N4T37_RS08070	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N4T37_RS08075	COG2116	formate transmembrane transporter activity
N4T37_RS08095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N4T37_RS08100	COG1335	isochorismatase
N4T37_RS08120	COG2983	Belongs to the UPF0260 family
N4T37_RS08155	COG2818	Glycosylase
N4T37_RS08160	COG1064	alcohol dehydrogenase
N4T37_RS08165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N4T37_RS08180	COG0583	DNA-binding transcription factor activity
N4T37_RS08185	COG0656	L-ascorbic acid biosynthetic process
N4T37_RS08190	COG2814	Major facilitator Superfamily
N4T37_RS08225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N4T37_RS08240	COG2233	PERMEase
N4T37_RS08245	COG0583	DNA-binding transcription factor activity
N4T37_RS08280	COG0733	neurotransmitter:sodium symporter activity
N4T37_RS08320	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N4T37_RS08325	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
N4T37_RS08330	COG0596	Alpha beta hydrolase
N4T37_RS08355	COG0488	(ABC) transporter
N4T37_RS08360	COG0586	Pfam SNARE associated Golgi protein
N4T37_RS08370	COG0187	DNA topoisomerase II activity
N4T37_RS08380	COG0592	DNA-directed DNA polymerase activity
N4T37_RS08405	COG0706	membrane insertase activity
N4T37_RS08420	COG1230	cation diffusion facilitator family transporter
N4T37_RS08425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N4T37_RS08440	COG0402	S-adenosylhomocysteine deaminase activity
N4T37_RS08450	COG0754	glutathionylspermidine amidase activity
N4T37_RS08460	COG0861	Integral membrane protein TerC family
N4T37_RS08465	COG0671	phosphoesterase, PA-phosphatase related
N4T37_RS08475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N4T37_RS08490	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
N4T37_RS08495	COG2951	lytic endotransglycosylase activity
N4T37_RS08525	COG0583	DNA-binding transcription factor activity
N4T37_RS08545	COG0657	acetylesterase activity
N4T37_RS08550	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N4T37_RS08590	COG1047	Peptidyl-prolyl cis-trans
N4T37_RS08600	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N4T37_RS08605	COG0196	riboflavin kinase activity
N4T37_RS08615	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N4T37_RS08620	COG1309	transcriptional regulator
N4T37_RS08625	COG1116	anion transmembrane transporter activity
N4T37_RS08630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N4T37_RS08635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N4T37_RS08640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N4T37_RS08645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N4T37_RS08665	COG1028	Short-chain dehydrogenase reductase Sdr
N4T37_RS08670	COG0546	phosphoglycolate phosphatase activity
N4T37_RS08730	COG3023	N-Acetylmuramoyl-L-alanine amidase
N4T37_RS08735	COG0728	peptidoglycan biosynthetic process
N4T37_RS08760	COG1596	polysaccharide export
N4T37_RS08765	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
N4T37_RS08770	COG1086	Polysaccharide biosynthesis protein
N4T37_RS08775	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N4T37_RS08780	COG1083	cytidylyl-transferase
N4T37_RS08795	COG2089	acid synthase
N4T37_RS08825	COG1216	Glycosyl transferase, family 2
N4T37_RS08830	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N4T37_RS08835	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N4T37_RS08850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N4T37_RS08855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N4T37_RS08865	COG2186	Transcriptional regulator
N4T37_RS08875	COG0277	FAD linked oxidase domain protein
N4T37_RS08880	COG1448	Aminotransferase
N4T37_RS08890	COG1802	Transcriptional regulator
N4T37_RS08905	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
N4T37_RS08965	COG0564	pseudouridine synthase activity
N4T37_RS09005	COG0251	oxidation-reduction process
N4T37_RS09010	COG1113	amino acid transport
N4T37_RS09015	COG1113	amino acid transport
N4T37_RS09035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N4T37_RS09040	COG1960	acyl-CoA dehydrogenase activity
N4T37_RS09045	COG1024	Enoyl-CoA hydratase
N4T37_RS09050	COG1024	Enoyl-CoA hydratase
N4T37_RS09055	COG0477	Major facilitator Superfamily
N4T37_RS09060	COG3916	Acyl-homoserine-lactone synthase
N4T37_RS09070	COG2197	response regulator
N4T37_RS09075	COG2826	transposase and inactivated derivatives, IS30 family
N4T37_RS09090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N4T37_RS09090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N4T37_RS09090	COG3321	synthase
N4T37_RS09090	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
N4T37_RS09110	COG2267	carboxylic ester hydrolase activity
N4T37_RS09130	COG0271	Belongs to the BolA IbaG family
N4T37_RS09140	COG1192	Involved in chromosome partitioning
N4T37_RS09155	COG0586	Pfam SNARE associated Golgi protein
N4T37_RS09160	COG2259	Doxx family
N4T37_RS09165	COG4399	Belongs to the UPF0754 family
N4T37_RS09170	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N4T37_RS09170	COG0519	Catalyzes the synthesis of GMP from XMP
N4T37_RS09215	COG0281	malic enzyme
N4T37_RS09225	COG2837	iron assimilation
N4T37_RS09230	COG1280	lysine exporter protein (LysE YggA)
N4T37_RS09235	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N4T37_RS09240	COG1121	(ABC) transporter
N4T37_RS09305	COG0386	Belongs to the glutathione peroxidase family
N4T37_RS09320	COG1309	transcriptional regulator
N4T37_RS09325	COG0697	spore germination
N4T37_RS09335	COG0758	DNA mediated transformation
N4T37_RS09405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N4T37_RS09415	COG0655	NAD(P)H dehydrogenase (quinone) activity
N4T37_RS09455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N4T37_RS09475	COG1253	flavin adenine dinucleotide binding
N4T37_RS09485	COG2860	membrane
N4T37_RS09490	COG0477	Major facilitator Superfamily
N4T37_RS09500	COG0318	PFAM AMP-dependent synthetase and ligase
N4T37_RS09515	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N4T37_RS09540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N4T37_RS09550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N4T37_RS09595	COG0589	response to stress
N4T37_RS09600	COG0659	secondary active sulfate transmembrane transporter activity
N4T37_RS09620	COG0347	Belongs to the P(II) protein family
N4T37_RS09625	COG0004	ammonium transporteR
N4T37_RS09635	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N4T37_RS09635	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N4T37_RS09675	COG0795	lipopolysaccharide-transporting ATPase activity
N4T37_RS09680	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
N4T37_RS09685	COG0793	Belongs to the peptidase S41A family
N4T37_RS09700	COG2197	response regulator
N4T37_RS09710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N4T37_RS09720	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N4T37_RS09725	COG4974	Belongs to the 'phage' integrase family
N4T37_RS09750	COG0772	Belongs to the SEDS family
N4T37_RS09755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N4T37_RS09760	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N4T37_RS09765	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N4T37_RS09790	COG0697	spore germination
N4T37_RS09795	COG1538	Outer membrane efflux protein
N4T37_RS09815	COG3275	phosphorelay sensor kinase activity
N4T37_RS09825	COG0181	hydroxymethylbilane synthase activity
N4T37_RS09870	COG1716	ATPase activity
N4T37_RS09875	COG0546	phosphoglycolate phosphatase activity
N4T37_RS09975	COG0596	Alpha beta hydrolase
N4T37_RS09980	COG2056	Na+-H+ antiporter family
N4T37_RS09995	COG0326	Molecular chaperone. Has ATPase activity
N4T37_RS10010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
N4T37_RS10080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N4T37_RS10085	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N4T37_RS10085	COG2169	Transcriptional regulator
N4T37_RS10115	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N4T37_RS10125	COG0497	DNA recombination
N4T37_RS10140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N4T37_RS10150	COG0237	dephospho-CoA kinase activity
N4T37_RS10200	COG0195	Participates in both transcription termination and antitermination
N4T37_RS10215	COG1320	monovalent cation:proton antiporter activity
N4T37_RS10220	COG2212	antiporter activity
N4T37_RS10225	COG1863	multisubunit Na H antiporter MnhE subunit
N4T37_RS10230	COG0651	ATP synthesis coupled electron transport
N4T37_RS10235	COG1006	Multisubunit Na H antiporter MnhC subunit
N4T37_RS10240	COG2111	Na H antiporter
N4T37_RS10240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N4T37_RS10255	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N4T37_RS10265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N4T37_RS10275	COG2226	methyltransferase
N4T37_RS10295	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
N4T37_RS10300	COG1074	ATP-dependent DNA helicase activity
N4T37_RS10305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N4T37_RS10310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N4T37_RS10325	COG0598	Magnesium transport protein CorA
N4T37_RS10330	COG0789	Transcriptional regulator
N4T37_RS10335	COG0484	heat shock protein binding
N4T37_RS10350	COG0475	glutathione-regulated potassium exporter activity
N4T37_RS10350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N4T37_RS10355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N4T37_RS10375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N4T37_RS10385	COG4535	Mg2 and Co2 transporter CorC
N4T37_RS10390	COG0425	Belongs to the sulfur carrier protein TusA family
N4T37_RS10395	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
N4T37_RS10395	COG0644	oxidoreductase
N4T37_RS10405	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N4T37_RS10420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N4T37_RS10425	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
N4T37_RS10435	COG0493	'glutamate synthase
N4T37_RS10435	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
N4T37_RS10465	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N4T37_RS10480	COG0534	Mate efflux family protein
N4T37_RS10490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N4T37_RS10495	COG1028	Short-chain dehydrogenase reductase Sdr
N4T37_RS10500	COG0583	DNA-binding transcription factor activity
N4T37_RS10515	COG0318	PFAM AMP-dependent synthetase and ligase
N4T37_RS10520	COG1530	ribonuclease E activity
N4T37_RS10530	COG0546	phosphoglycolate phosphatase activity
N4T37_RS10535	COG2378	regulation of single-species biofilm formation
N4T37_RS10540	COG0625	glutathione transferase activity
N4T37_RS10550	COG0583	DNA-binding transcription factor activity
N4T37_RS10615	COG0473	3-isopropylmalate dehydrogenase activity
N4T37_RS10670	COG1301	dicarboxylic acid transport
N4T37_RS10680	COG1560	Kdo2-lipid A biosynthetic process
N4T37_RS10685	COG1280	lysine exporter protein (LysE YggA)
N4T37_RS10690	COG0488	(ABC) transporter
N4T37_RS10695	COG2900	Belongs to the SlyX family
N4T37_RS10705	COG1733	regulation of RNA biosynthetic process
N4T37_RS10730	COG0210	DNA helicase
N4T37_RS10735	COG0724	RNA recognition motif
N4T37_RS10755	COG4651	solute:proton antiporter activity
N4T37_RS10755	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N4T37_RS10780	COG0788	formyltetrahydrofolate deformylase activity
N4T37_RS10880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N4T37_RS10880	COG2813	Specifically methylates the guanine in position
N4T37_RS10890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N4T37_RS10900	COG4774	siderophore transport
N4T37_RS10910	COG0740	serine-type endopeptidase activity
N4T37_RS10930	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
N4T37_RS10930	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
N4T37_RS10935	COG0280	phosphate acetyltransferase
N4T37_RS10935	COG0857	belongs to the CobB CobQ family
N4T37_RS10940	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N4T37_RS10950	COG0800	Aldolase
N4T37_RS10960	COG3265	gluconokinase activity
N4T37_RS10965	COG1012	belongs to the aldehyde dehydrogenase family
N4T37_RS10975	COG2267	carboxylic ester hydrolase activity
N4T37_RS10990	COG0793	Belongs to the peptidase S41A family
N4T37_RS11025	COG1426	Protein conserved in bacteria
N4T37_RS11065	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N4T37_RS11075	COG1162	GTPase activity
N4T37_RS11080	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
N4T37_RS11095	COG1538	Outer membrane efflux protein
N4T37_RS11100	COG1136	(ABC) transporter
N4T37_RS11100	COG0577	efflux transmembrane transporter activity
N4T37_RS11105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N4T37_RS11130	COG0028	Belongs to the TPP enzyme family
N4T37_RS11135	COG0440	acetolactate synthase activity
N4T37_RS11160	COG2826	transposase and inactivated derivatives, IS30 family
N4T37_RS11170	COG2826	transposase and inactivated derivatives, IS30 family
N4T37_RS11180	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
N4T37_RS11195	COG0084	hydrolase, TatD family'
N4T37_RS11210	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
N4T37_RS11220	COG0583	DNA-binding transcription factor activity
N4T37_RS11230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N4T37_RS11235	COG2814	Major facilitator Superfamily
N4T37_RS11245	COG0697	spore germination
N4T37_RS11275	COG3622	Belongs to the hyi family
N4T37_RS11280	COG2084	Dehydrogenase
N4T37_RS11285	COG1024	Enoyl-CoA hydratase
N4T37_RS11290	COG0784	Response regulator, receiver
N4T37_RS11290	COG2205	protein histidine kinase activity
N4T37_RS11290	COG5002	protein histidine kinase activity
N4T37_RS11310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N4T37_RS11320	COG3956	TIGRFAM MazG family protein
N4T37_RS11325	COG1555	photosystem II stabilization
N4T37_RS11330	COG0617	tRNA 3'-terminal CCA addition
N4T37_RS11335	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N4T37_RS11355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N4T37_RS11360	COG3028	Belongs to the UPF0307 family
N4T37_RS11365	COG0318	PFAM AMP-dependent synthetase and ligase
N4T37_RS11380	COG0625	glutathione transferase activity
N4T37_RS11385	COG1238	metal cluster binding
N4T37_RS11425	COG0072	phenylalanine-tRNA ligase activity
N4T37_RS11455	COG0248	Ppx GppA phosphatase
N4T37_RS11465	COG0037	tRNA processing
N4T37_RS11505	COG1764	response to oxidative stress
N4T37_RS11510	COG1846	Transcriptional regulator
N4T37_RS11520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N4T37_RS11580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N4T37_RS11585	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N4T37_RS11590	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N4T37_RS11650	COG1214	PFAM Peptidase M22, glycoprotease
N4T37_RS11665	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
N4T37_RS11675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N4T37_RS11680	COG0561	phosphatase activity
N4T37_RS11690	COG2132	Multicopper oxidase
N4T37_RS11710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N4T37_RS11715	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
N4T37_RS11720	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
N4T37_RS11750	COG1063	alcohol dehydrogenase
N4T37_RS11755	COG0583	DNA-binding transcription factor activity
N4T37_RS11760	COG1960	acyl-CoA dehydrogenase activity
N4T37_RS11765	COG2814	Major facilitator Superfamily
N4T37_RS11770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N4T37_RS11780	COG1053	succinate dehydrogenase
N4T37_RS11785	COG0583	DNA-binding transcription factor activity
N4T37_RS11800	COG0583	DNA-binding transcription factor activity
N4T37_RS11830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N4T37_RS11890	COG0384	phenazine biosynthesis protein PhzF
N4T37_RS11900	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N4T37_RS11920	COG0745	RESPONSE REGULATOR receiver
N4T37_RS11960	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
N4T37_RS11990	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N4T37_RS11995	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N4T37_RS12015	COG0583	DNA-binding transcription factor activity
N4T37_RS12035	COG0668	transmembrane transport
N4T37_RS12045	COG2081	HI0933 family
N4T37_RS12050	COG2515	1-aminocyclopropane-1-carboxylate deaminase
N4T37_RS12080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N4T37_RS12080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N4T37_RS12090	COG0489	protein tyrosine kinase activity
N4T37_RS12140	COG0305	Participates in initiation and elongation during chromosome replication
N4T37_RS12180	COG0582	viral genome integration into host DNA
N4T37_RS12190	COG1113	amino acid transport
N4T37_RS12195	COG2828	Protein conserved in bacteria
N4T37_RS12200	COG0142	geranyltranstransferase activity
N4T37_RS12205	COG2315	Protein conserved in bacteria
N4T37_RS12220	COG1752	Esterase of the alpha-beta hydrolase superfamily
N4T37_RS12240	COG2194	sulfuric ester hydrolase activity
N4T37_RS12245	COG0745	RESPONSE REGULATOR receiver
N4T37_RS12250	COG0642	Histidine kinase
N4T37_RS12260	COG0004	ammonium transporteR
N4T37_RS12285	COG0525	valine-tRNA ligase activity
N4T37_RS12295	COG1028	Short-chain dehydrogenase reductase Sdr
N4T37_RS12305	COG0393	Putative heavy-metal-binding
N4T37_RS12310	COG0393	Putative heavy-metal-binding
N4T37_RS12315	COG1538	Outer membrane efflux protein
N4T37_RS12325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N4T37_RS12330	COG0671	phosphoesterase, PA-phosphatase related
N4T37_RS12335	COG0215	cysteine-tRNA ligase activity
N4T37_RS12360	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
N4T37_RS12375	COG1648	precorrin-2 dehydrogenase activity
N4T37_RS12375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N4T37_RS12380	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N4T37_RS12385	COG1733	regulation of RNA biosynthetic process
N4T37_RS12395	COG0531	amino acid
N4T37_RS12410	COG0321	lipoyl(octanoyl) transferase activity
N4T37_RS12415	COG2921	Belongs to the UPF0250 family
N4T37_RS12450	COG2009	succinate dehydrogenase
N4T37_RS12455	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
N4T37_RS12460	COG1053	succinate dehydrogenase
N4T37_RS12465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N4T37_RS12490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N4T37_RS12510	COG2354	Protein conserved in bacteria
N4T37_RS12515	COG2321	neutral zinc metallopeptidase
N4T37_RS12535	COG2843	Capsule synthesis protein
N4T37_RS12550	COG0589	response to stress
N4T37_RS12570	COG0505	Belongs to the CarA family
N4T37_RS12595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N4T37_RS12600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N4T37_RS12650	COG0477	Major facilitator Superfamily
N4T37_RS12655	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N4T37_RS12670	COG1597	lipid kinase activity
N4T37_RS12675	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N4T37_RS12705	COG0584	glycerophosphoryl diester phosphodiesterase
N4T37_RS12725	COG0741	lytic transglycosylase activity
N4T37_RS12745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N4T37_RS12770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N4T37_RS12780	COG3811	Belongs to the UPF0386 family
N4T37_RS12825	COG0778	Nitroreductase
N4T37_RS12840	COG1929	Belongs to the glycerate kinase type-1 family
N4T37_RS12845	COG0243	molybdopterin cofactor binding
N4T37_RS12850	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N4T37_RS12855	COG3339	Conserved Protein
N4T37_RS12865	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
N4T37_RS12880	COG1113	amino acid transport
N4T37_RS12890	COG0019	diaminopimelate decarboxylase activity
N4T37_RS12900	COG1280	lysine exporter protein (LysE YggA)
N4T37_RS12905	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N4T37_RS12935	COG0463	Glycosyl transferase, family 2
N4T37_RS12955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N4T37_RS12990	COG4591	ABC-type transport system involved in lipoprotein release permease component
N4T37_RS12995	COG1136	(ABC) transporter
N4T37_RS13000	COG0658	competence protein
N4T37_RS13000	COG2333	competence protein COMEC
N4T37_RS13010	COG0616	signal peptide processing
N4T37_RS13010	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N4T37_RS13015	COG0596	Alpha beta hydrolase
N4T37_RS13020	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N4T37_RS13030	COG0628	permease
N4T37_RS13065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N4T37_RS13085	COG0823	Involved in the tonB-independent uptake of proteins
N4T37_RS13105	COG0824	Thioesterase
N4T37_RS13110	COG1473	amidohydrolase
N4T37_RS13130	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N4T37_RS13130	COG0047	phosphoribosylformylglycinamidine synthase activity
N4T37_RS13135	COG2814	Major facilitator Superfamily
N4T37_RS13150	COG1024	Enoyl-CoA hydratase
N4T37_RS13155	COG1051	belongs to the nudix hydrolase family
N4T37_RS13155	COG1056	cytidyltransferase-related domain
N4T37_RS13165	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N4T37_RS13180	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
N4T37_RS13195	COG4625	pathogenesis
N4T37_RS13200	COG0583	DNA-binding transcription factor activity
N4T37_RS13205	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
N4T37_RS13210	COG4208	sulfate ABC transporter
N4T37_RS13215	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
N4T37_RS13225	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
N4T37_RS13230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N4T37_RS13235	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N4T37_RS13255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N4T37_RS13270	COG0681	Belongs to the peptidase S26 family
N4T37_RS13285	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N4T37_RS13295	COG1381	Involved in DNA repair and RecF pathway recombination
N4T37_RS13300	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
N4T37_RS13310	COG4221	oxidoreductase activity
N4T37_RS13350	COG0436	Aminotransferase
N4T37_RS13365	COG2826	transposase and inactivated derivatives, IS30 family
N4T37_RS13375	COG0556	nucleotide-excision repair
N4T37_RS13430	COG2070	2-Nitropropane dioxygenase
N4T37_RS13460	COG1215	transferase activity, transferring glycosyl groups
N4T37_RS13475	COG0415	Belongs to the DNA photolyase family
N4T37_RS13485	COG1252	NADH dehydrogenase
N4T37_RS13490	COG1686	Belongs to the peptidase S11 family
N4T37_RS13505	COG1187	pseudouridine synthase activity
N4T37_RS13530	COG0477	Major facilitator Superfamily
N4T37_RS13535	COG0583	DNA-binding transcription factor activity
N4T37_RS13540	COG1823	symporter activity
N4T37_RS13550	COG0612	Peptidase, M16
N4T37_RS13575	COG0352	thiamine-phosphate diphosphorylase activity
N4T37_RS13610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N4T37_RS13625	COG1309	transcriptional regulator
N4T37_RS13635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N4T37_RS13640	COG0076	glutamate decarboxylase activity
N4T37_RS13650	COG1522	sequence-specific DNA binding
N4T37_RS13655	COG3961	Belongs to the TPP enzyme family
N4T37_RS13660	COG1113	amino acid transport
N4T37_RS13665	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N4T37_RS13670	COG0573	inorganic phosphate transmembrane transporter activity
N4T37_RS13680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N4T37_RS13685	COG0616	signal peptide processing
N4T37_RS13720	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
N4T37_RS13725	COG1686	Belongs to the peptidase S11 family
N4T37_RS13750	COG0583	DNA-binding transcription factor activity
N4T37_RS13755	COG1067	ATP-dependent peptidase activity
N4T37_RS13760	COG2211	Major facilitator Superfamily
N4T37_RS13780	COG4943	cyclic-guanylate-specific phosphodiesterase activity
N4T37_RS13800	COG1966	Carbon starvation protein
N4T37_RS13805	COG2879	small protein
N4T37_RS13825	COG1741	Belongs to the pirin family
N4T37_RS13835	COG2964	Protein conserved in bacteria
N4T37_RS13850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N4T37_RS13855	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N4T37_RS13860	COG4605	iron ion homeostasis
N4T37_RS13865	COG4604	ABC transporter, ATP-binding protein
N4T37_RS13870	COG4607	ABC-type enterochelin transport system periplasmic component
N4T37_RS13875	COG4774	siderophore transport
N4T37_RS13885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N4T37_RS13890	COG1021	2,3-dihydroxybenzoate-AMP ligase
N4T37_RS13895	COG1535	isochorismatase
N4T37_RS13895	COG3433	isochorismatase activity
N4T37_RS13905	COG1132	(ABC) transporter
N4T37_RS13910	COG1132	(ABC) transporter
N4T37_RS13915	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
N4T37_RS13925	COG1169	isochorismate synthase
N4T37_RS13940	COG3739	integral membrane protein
N4T37_RS13965	COG0302	gtp cyclohydrolase
N4T37_RS13975	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N4T37_RS14010	COG0512	Glutamine amidotransferase of anthranilate synthase
N4T37_RS14185	COG5410	chromosome segregation
N4T37_RS14305	COG1598	PFAM Uncharacterised protein family UPF0150
N4T37_RS14380	COG0582	viral genome integration into host DNA
N4T37_RS14395	COG0174	glutamine synthetase
N4T37_RS14405	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
N4T37_RS14440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N4T37_RS14445	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N4T37_RS14450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N4T37_RS14480	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N4T37_RS14485	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N4T37_RS14490	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
N4T37_RS14505	COG1960	acyl-CoA dehydrogenase activity
N4T37_RS14510	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N4T37_RS14515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N4T37_RS14525	COG2223	nitrite transmembrane transporter activity
N4T37_RS14535	COG0024	Methionine aminopeptidase
N4T37_RS14540	COG0052	Belongs to the universal ribosomal protein uS2 family
N4T37_RS14555	COG2207	Transcriptional regulator
N4T37_RS14580	COG2951	lytic endotransglycosylase activity
N4T37_RS14585	COG0772	Belongs to the SEDS family
N4T37_RS14600	COG0842	Transport permease protein
N4T37_RS14605	COG1131	(ABC) transporter
N4T37_RS14610	COG0582	viral genome integration into host DNA
N4T37_RS14925	COG0739	heme binding
N4T37_RS15045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N4T37_RS15070	COG4215	(ABC) transporter
N4T37_RS15075	COG4160	amino acid transport
N4T37_RS15080	COG4598	ABC transporter
N4T37_RS15090	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N4T37_RS15095	COG0826	peptidase U32
N4T37_RS15100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N4T37_RS15115	COG1720	tRNA m6t6A37 methyltransferase activity
N4T37_RS15125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N4T37_RS15140	COG0642	Histidine kinase
N4T37_RS15150	COG0494	nUDIX hydrolase
N4T37_RS15160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N4T37_RS15165	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N4T37_RS15170	COG3139	Protein of unknown function (DUF1315)
N4T37_RS15175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N4T37_RS15180	COG1301	dicarboxylic acid transport
N4T37_RS15185	COG1960	acyl-CoA dehydrogenase activity
N4T37_RS15190	COG2819	hydrolase of the alpha beta superfamily
N4T37_RS15200	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N4T37_RS15210	COG2195	Cleaves the N-terminal amino acid of tripeptides
N4T37_RS15215	COG1234	tRNA 3'-trailer cleavage
N4T37_RS15245	COG2363	Small membrane protein
N4T37_RS15270	COG0513	Belongs to the DEAD box helicase family
N4T37_RS15280	COG0778	Nitroreductase
N4T37_RS15310	COG1286	toxin biosynthetic process
N4T37_RS15340	COG1610	YqeY-like protein
N4T37_RS15395	COG2831	hemolysin activation secretion protein
N4T37_RS15400	COG3210	domain, Protein
N4T37_RS15400	COG3210	domain, Protein
N4T37_RS15480	COG3111	PFAM Bacterial OB fold (BOF) protein
N4T37_RS15505	COG3243	poly(R)-hydroxyalkanoic acid synthase
N4T37_RS15510	COG0786	glutamate:sodium symporter activity
N4T37_RS15520	COG2186	Transcriptional regulator
N4T37_RS15570	COG0477	Major facilitator Superfamily
N4T37_RS15590	COG2826	transposase and inactivated derivatives, IS30 family
N4T37_RS15605	COG2985	domain, Protein
N4T37_RS15615	COG2995	paraquat-inducible protein a
N4T37_RS15620	COG3008	intermembrane lipid transfer
N4T37_RS15620	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N4T37_RS15630	COG1794	racemase activity, acting on amino acids and derivatives
N4T37_RS15665	COG1301	dicarboxylic acid transport
N4T37_RS15675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N4T37_RS15680	COG2011	ABC-type metal ion transport system permease component
N4T37_RS15685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N4T37_RS15690	COG1464	Belongs to the NlpA lipoprotein family
N4T37_RS15695	COG0151	Belongs to the GarS family
N4T37_RS15700	COG0138	bifunctional purine biosynthesis protein purh
N4T37_RS15705	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
N4T37_RS15735	COG2308	Evidence 4 Homologs of previously reported genes of
N4T37_RS15745	COG1305	Transglutaminase-like
N4T37_RS15755	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N4T37_RS15760	COG0305	Participates in initiation and elongation during chromosome replication
N4T37_RS15785	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
N4T37_RS15795	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N4T37_RS15800	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
N4T37_RS15825	COG1649	PFAM Uncharacterised BCR, COG1649
N4T37_RS15825	COG0726	polysaccharide deacetylase
N4T37_RS15830	COG1215	transferase activity, transferring glycosyl groups
N4T37_RS15835	COG3658	cytochrome
N4T37_RS15845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N4T37_RS15860	COG0583	DNA-binding transcription factor activity
N4T37_RS15890	COG1960	acyl-CoA dehydrogenase activity
N4T37_RS15895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N4T37_RS15900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N4T37_RS15925	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
N4T37_RS15930	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
N4T37_RS15940	COG2205	protein histidine kinase activity
N4T37_RS15945	COG0745	RESPONSE REGULATOR receiver
N4T37_RS15950	COG0174	glutamine synthetase
N4T37_RS15970	COG0729	surface antigen
N4T37_RS16010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N4T37_RS16105	COG1484	DNA-dependent DNA replication
N4T37_RS16325	COG2026	Addiction module toxin, RelE StbE family
N4T37_RS16365	COG0592	DNA-directed DNA polymerase activity
N4T37_RS16395	COG4372	Transposase
N4T37_RS16405	COG2963	transposase activity
N4T37_RS16415	COG2826	transposase and inactivated derivatives, IS30 family
N4T37_RS16470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N4T37_RS16495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N4T37_RS16500	COG2814	Major facilitator Superfamily
N4T37_RS16515	COG0583	DNA-binding transcription factor activity
N4T37_RS16530	COG1187	pseudouridine synthase activity
N4T37_RS16550	COG0802	atpase or kinase
N4T37_RS16555	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
N4T37_RS16565	COG1923	regulation of RNA biosynthetic process
N4T37_RS16570	COG0697	spore germination
N4T37_RS16595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N4T37_RS16600	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N4T37_RS16600	COG0519	Catalyzes the synthesis of GMP from XMP
N4T37_RS16605	COG4302	ethanolamine ammonia-lyase activity
N4T37_RS16610	COG4303	Ethanolamine ammonia lyase large subunit
N4T37_RS16615	COG0531	amino acid
N4T37_RS16635	COG1454	alcohol dehydrogenase
N4T37_RS16640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N4T37_RS16665	COG0308	aminopeptidase N
N4T37_RS16685	COG1605	Chorismate mutase
N4T37_RS16705	COG1309	transcriptional regulator
N4T37_RS16715	COG0668	transmembrane transport
N4T37_RS16745	COG4773	Receptor
N4T37_RS16765	COG0488	(ABC) transporter
N4T37_RS16770	COG0589	response to stress
N4T37_RS16810	COG3135	benzoate transporter
N4T37_RS16815	COG1522	sequence-specific DNA binding
N4T37_RS16825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N4T37_RS16830	COG0583	DNA-binding transcription factor activity
N4T37_RS16840	COG0183	Belongs to the thiolase family
N4T37_RS16850	COG2030	dehydratase
N4T37_RS16855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N4T37_RS16880	COG0824	Thioesterase
N4T37_RS16885	COG1454	alcohol dehydrogenase
N4T37_RS16895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N4T37_RS16915	COG0069	glutamate synthase activity
N4T37_RS16935	COG2814	Major facilitator Superfamily
N4T37_RS16950	COG0511	ligase activity, forming carbon-carbon bonds
N4T37_RS16965	COG1116	anion transmembrane transporter activity
N4T37_RS16965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N4T37_RS16970	COG0745	RESPONSE REGULATOR receiver
N4T37_RS16980	COG2146	nitrite reductase [NAD(P)H] activity
N4T37_RS16980	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N4T37_RS16985	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N4T37_RS16990	COG0243	molybdopterin cofactor binding
N4T37_RS17000	COG0243	molybdopterin cofactor binding
N4T37_RS17005	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N4T37_RS17020	COG0315	cyclic pyranopterin monophosphate synthase activity
N4T37_RS17020	COG0521	Mo-molybdopterin cofactor biosynthetic process
N4T37_RS17025	COG0303	'Molybdopterin
N4T37_RS17035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N4T37_RS17060	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
N4T37_RS17065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N4T37_RS17120	COG2204	response regulator
N4T37_RS17125	COG3852	Histidine kinase
N4T37_RS17150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N4T37_RS17155	COG0575	Belongs to the CDS family
N4T37_RS17190	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N4T37_RS17205	COG2137	regulation of response to DNA damage stimulus
N4T37_RS17215	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N4T37_RS17220	COG1011	Hydrolase
N4T37_RS17245	COG1522	sequence-specific DNA binding
N4T37_RS17255	COG1113	amino acid transport
N4T37_RS17275	COG0659	secondary active sulfate transmembrane transporter activity
N4T37_RS17280	COG2135	peptidase activity
N4T37_RS17295	COG5001	Diguanylate cyclase
N4T37_RS17295	COG3300	MHYT domain
N4T37_RS17315	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
N4T37_RS17315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N4T37_RS17315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N4T37_RS17320	COG1105	Belongs to the carbohydrate kinase PfkB family
N4T37_RS17325	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N4T37_RS17325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N4T37_RS17355	COG0024	Methionine aminopeptidase
N4T37_RS17360	COG0583	DNA-binding transcription factor activity
N4T37_RS17370	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
N4T37_RS17375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N4T37_RS17380	COG0517	IMP dehydrogenase activity
N4T37_RS17380	COG0516	GMP reductase activity
N4T37_RS17405	COG0552	protein localization to endoplasmic reticulum
N4T37_RS17415	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
N4T37_RS17430	COG4890	Cyd operon protein YbgT
N4T37_RS17435	COG1294	oxidase, subunit
N4T37_RS17455	COG1585	Membrane protein implicated in regulation of membrane protease activity
N4T37_RS17465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N4T37_RS17490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N4T37_RS17495	COG0569	domain protein
N4T37_RS17500	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N4T37_RS17540	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N4T37_RS17545	COG0542	response to heat
N4T37_RS17570	COG1902	pentaerythritol trinitrate reductase activity
N4T37_RS17570	COG0446	pyridine nucleotide-disulphide oxidoreductase
N4T37_RS17615	COG2323	membrane
N4T37_RS17620	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
N4T37_RS17630	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
N4T37_RS17635	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N4T37_RS17640	COG0183	Belongs to the thiolase family
N4T37_RS17645	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N4T37_RS17650	COG0596	Alpha beta hydrolase
N4T37_RS17655	COG2271	Major facilitator Superfamily
N4T37_RS17660	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N4T37_RS17665	COG3485	protocatechuate 3,4-dioxygenase
N4T37_RS17670	COG3485	protocatechuate 3,4-dioxygenase
N4T37_RS17675	COG0710	3-dehydroquinate dehydratase activity
N4T37_RS17680	COG3420	alginic acid biosynthetic process
N4T37_RS17685	COG3659	wide pore channel activity
N4T37_RS17690	COG4993	Dehydrogenase
N4T37_RS17700	COG3293	Transposase
N4T37_RS17705	COG2391	methyltransferase activity
N4T37_RS17720	COG1414	Transcriptional regulator
N4T37_RS17725	COG0583	DNA-binding transcription factor activity
N4T37_RS17730	COG1960	acyl-CoA dehydrogenase activity
N4T37_RS17810	COG2188	Transcriptional regulator
N4T37_RS17825	COG0583	DNA-binding transcription factor activity
N4T37_RS17860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N4T37_RS17895	COG1960	acyl-CoA dehydrogenase activity
N4T37_RS17900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N4T37_RS17905	COG1846	Transcriptional regulator
N4T37_RS17910	COG1012	belongs to the aldehyde dehydrogenase family
N4T37_RS17915	COG0129	dihydroxy-acid dehydratase activity
N4T37_RS17925	COG0583	DNA-binding transcription factor activity
N4T37_RS17930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N4T37_RS17940	COG2084	Dehydrogenase
N4T37_RS17945	COG2207	Transcriptional regulator
N4T37_RS17950	COG1064	alcohol dehydrogenase
N4T37_RS17960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N4T37_RS17965	COG1120	ATPase activity
N4T37_RS17985	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N4T37_RS18030	COG2826	transposase and inactivated derivatives, IS30 family
N4T37_RS18075	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
N4T37_RS18100	COG2814	Major facilitator Superfamily
N4T37_RS18120	COG2205	protein histidine kinase activity
N4T37_RS18155	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
N4T37_RS18165	COG0753	catalase activity
N4T37_RS18245	COG1535	isochorismatase
N4T37_RS18245	COG3433	isochorismatase activity
N4T37_RS18250	COG1028	Short-chain dehydrogenase reductase Sdr
N4T37_RS18255	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
N4T37_RS18260	COG4149	molybdate abc transporter
N4T37_RS18265	COG0725	ABC transporter, periplasmic molybdate-binding protein
N4T37_RS18275	COG4638	Rieske (2fe-2S)
N4T37_RS18280	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
N4T37_RS18285	COG0543	2 iron, 2 sulfur cluster binding
N4T37_RS18285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N4T37_RS18300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N4T37_RS18310	COG1028	Short-chain dehydrogenase reductase Sdr
N4T37_RS18325	COG2207	Transcriptional regulator
N4T37_RS18330	COG1028	Short-chain dehydrogenase reductase Sdr
N4T37_RS18335	COG2610	gluconate transmembrane transporter activity
N4T37_RS18350	COG1309	transcriptional regulator
N4T37_RS18365	COG2826	transposase and inactivated derivatives, IS30 family
N4T37_RS18375	COG0583	DNA-binding transcription factor activity
N4T37_RS18390	COG2031	fatty acid transporter
N4T37_RS18395	COG0183	Belongs to the thiolase family
N4T37_RS18400	COG0583	DNA-binding transcription factor activity
N4T37_RS18405	COG0583	DNA-binding transcription factor activity
N4T37_RS18420	COG1027	Aspartate ammonia-lyase
N4T37_RS18430	COG0477	Major facilitator Superfamily
N4T37_RS18465	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N4T37_RS18490	COG2963	transposase activity
N4T37_RS18500	COG4372	Transposase
N4T37_RS18515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N4T37_RS18520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N4T37_RS18525	COG1538	Outer membrane efflux protein
N4T37_RS18530	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N4T37_RS18545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N4T37_RS18580	COG0798	PFAM Bile acid sodium symporter
N4T37_RS18615	COG4691	Plasmid stability protein
N4T37_RS18640	COG0431	NADPH-dependent FMN reductase
N4T37_RS18645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N4T37_RS18705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N4T37_RS18710	COG4521	taurine ABC transporter
N4T37_RS18725	COG2188	Transcriptional regulator
N4T37_RS18735	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
N4T37_RS18740	COG1733	regulation of RNA biosynthetic process
N4T37_RS18745	COG2207	Transcriptional regulator
N4T37_RS18745	COG3708	Transcriptional regulator
N4T37_RS18760	COG0730	response to heat
N4T37_RS18775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N4T37_RS18775	COG3453	Protein conserved in bacteria
N4T37_RS18785	COG3781	membrane
N4T37_RS18790	COG1063	alcohol dehydrogenase
N4T37_RS18805	COG0508	dehydrogenase complex catalyzes the overall conversion of
N4T37_RS18810	COG0022	dehydrogenase e1 component
N4T37_RS18815	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
N4T37_RS18820	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N4T37_RS18835	COG3706	GGDEF domain
N4T37_RS18850	COG0133	tryptophan synthase activity
N4T37_RS18860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N4T37_RS18895	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N4T37_RS18920	COG2226	methyltransferase
N4T37_RS18980	COG0842	Transport permease protein
N4T37_RS18985	COG0842	Transport permease protein
N4T37_RS19005	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N4T37_RS19010	COG4773	Receptor
N4T37_RS19030	COG0730	response to heat
N4T37_RS19035	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N4T37_RS19050	COG0406	alpha-ribazole phosphatase activity
N4T37_RS19075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N4T37_RS19105	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N4T37_RS19115	COG4264	IucA IucC family
N4T37_RS19120	COG4264	IucA IucC family
N4T37_RS19125	COG2814	Major facilitator Superfamily
N4T37_RS19140	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N4T37_RS19155	COG1960	acyl-CoA dehydrogenase activity
N4T37_RS19160	COG1960	acyl-CoA dehydrogenase activity
N4T37_RS19165	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N4T37_RS19170	COG2207	Transcriptional regulator
N4T37_RS19175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N4T37_RS19180	COG0776	regulation of translation
N4T37_RS19205	COG0822	iron-sulfur transferase activity
N4T37_RS19210	COG0316	Belongs to the HesB IscA family
N4T37_RS19240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N4T37_RS19260	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N4T37_RS19265	COG0702	epimerase
N4T37_RS19300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N4T37_RS19310	COG0339	signal peptide processing
N4T37_RS19360	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N4T37_RS19365	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
N4T37_RS19395	COG0776	regulation of translation
N4T37_RS19460	COG0084	hydrolase, TatD family'
N4T37_RS19480	COG1663	tetraacyldisaccharide 4'-kinase activity
N4T37_RS19485	COG1132	(ABC) transporter
N4T37_RS19495	COG0811	peptide transport
N4T37_RS19500	COG1475	DNA binding
N4T37_RS19505	COG1192	Involved in chromosome partitioning
N4T37_RS19515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
N4T37_RS19530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N4T37_RS19535	COG0191	fructose-bisphosphate aldolase activity
N4T37_RS19555	COG0424	maF-like protein
N4T37_RS19560	COG2850	peptidyl-arginine hydroxylation
N4T37_RS19570	COG0640	Transcriptional regulator
N4T37_RS19580	COG3619	membrane
N4T37_RS19585	COG3122	Protein conserved in bacteria
N4T37_RS19590	COG1132	(ABC) transporter
N4T37_RS19610	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N4T37_RS19615	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N4T37_RS19625	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
N4T37_RS19625	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
N4T37_RS19625	COG0506	proline dehydrogenase activity
N4T37_RS19630	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
N4T37_RS19645	COG3698	Phosphodiester glycosidase
N4T37_RS19655	COG2353	YceI-like domain
N4T37_RS19665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N4T37_RS19710	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
N4T37_RS19710	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N4T37_RS19735	COG3539	Fimbrial protein
N4T37_RS19740	COG3121	Chaperone
N4T37_RS19765	COG0697	spore germination
N4T37_RS19775	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
N4T37_RS19805	COG1309	transcriptional regulator
N4T37_RS19820	COG1522	sequence-specific DNA binding
N4T37_RS19830	COG1126	abc transporter atp-binding protein
N4T37_RS19835	COG0765	amino acid transport
N4T37_RS19840	COG0765	amino acid transport
N4T37_RS19870	COG1464	Belongs to the NlpA lipoprotein family
N4T37_RS19880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N4T37_RS19885	COG2011	ABC-type metal ion transport system permease component
N4T37_RS19890	COG0012	GTP binding
N4T37_RS19915	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
N4T37_RS19940	COG0436	Aminotransferase
N4T37_RS19955	COG0386	Belongs to the glutathione peroxidase family
N4T37_RS19965	COG0436	Aminotransferase
N4T37_RS19970	COG1301	dicarboxylic acid transport
N4T37_RS20005	COG3634	alkyl hydroperoxide reductase activity
N4T37_RS20020	COG0583	DNA-binding transcription factor activity
N4T37_RS20025	COG0798	PFAM Bile acid sodium symporter
N4T37_RS20030	COG0640	Transcriptional regulator
N4T37_RS20045	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
N4T37_RS20055	COG0583	DNA-binding transcription factor activity
N4T37_RS20065	COG1953	Uracil, thiamine, allantoin
N4T37_RS20075	COG2175	clavaminate synthase activity
N4T37_RS20080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N4T37_RS20090	COG4521	taurine ABC transporter
N4T37_RS20105	COG0477	Major facilitator Superfamily
N4T37_RS20125	COG1271	oxidase subunit
N4T37_RS20130	COG1294	oxidase, subunit
N4T37_RS20140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N4T37_RS20160	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N4T37_RS20180	COG3052	prosthetic group binding
N4T37_RS20185	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
N4T37_RS20195	COG0583	DNA-binding transcription factor activity
N4T37_RS20205	COG2814	Major facilitator Superfamily
N4T37_RS20225	COG1346	cytolysis
N4T37_RS20235	COG0583	DNA-binding transcription factor activity
N4T37_RS20240	COG0625	glutathione transferase activity
N4T37_RS20245	COG0625	glutathione transferase activity
N4T37_RS20250	COG0583	DNA-binding transcription factor activity
N4T37_RS20265	COG1045	serine acetyltransferase
N4T37_RS20270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N4T37_RS20275	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N4T37_RS20285	COG1280	lysine exporter protein (LysE YggA)
N4T37_RS20305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N4T37_RS20310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N4T37_RS20315	COG1126	abc transporter atp-binding protein
N4T37_RS20320	COG0765	amino acid transport
N4T37_RS20325	COG0765	amino acid transport
N4T37_RS20345	COG2205	protein histidine kinase activity
N4T37_RS20345	COG0784	Response regulator, receiver
N4T37_RS20365	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N4T37_RS20385	COG1028	Short-chain dehydrogenase reductase Sdr
N4T37_RS20435	COG0583	DNA-binding transcription factor activity
N4T37_RS20455	COG0318	PFAM AMP-dependent synthetase and ligase
N4T37_RS20460	COG1309	transcriptional regulator
N4T37_RS20465	COG1960	acyl-CoA dehydrogenase activity
N4T37_RS20470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N4T37_RS20475	COG1024	Enoyl-CoA hydratase
N4T37_RS20480	COG4770	biotin carboxylase activity
N4T37_RS20490	COG0583	DNA-binding transcription factor activity
N4T37_RS20505	COG1960	acyl-CoA dehydrogenase activity
N4T37_RS20515	COG2814	Major facilitator Superfamily
N4T37_RS20525	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N4T37_RS20530	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
N4T37_RS20535	COG2814	Major facilitator Superfamily
N4T37_RS20540	COG1960	acyl-CoA dehydrogenase activity
N4T37_RS20545	COG1024	Enoyl-CoA hydratase
N4T37_RS20550	COG1028	Short-chain dehydrogenase reductase Sdr
N4T37_RS20555	COG1250	3-hydroxyacyl-CoA dehydrogenase
N4T37_RS20560	COG0183	Belongs to the thiolase family
N4T37_RS20580	COG1280	lysine exporter protein (LysE YggA)
N4T37_RS20585	COG2192	nodulation
N4T37_RS20600	COG1024	Enoyl-CoA hydratase
N4T37_RS20615	COG1960	acyl-CoA dehydrogenase activity
N4T37_RS20620	COG2814	Major facilitator Superfamily
N4T37_RS20625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N4T37_RS20630	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
N4T37_RS20645	COG3842	ATPase activity
N4T37_RS20650	COG1840	ABC-type Fe3 transport system, periplasmic component
N4T37_RS20660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N4T37_RS20665	COG1414	Transcriptional regulator
N4T37_RS20675	COG0583	DNA-binding transcription factor activity
N4T37_RS20680	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N4T37_RS20685	COG1012	belongs to the aldehyde dehydrogenase family
N4T37_RS20700	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
N4T37_RS20710	COG1012	belongs to the aldehyde dehydrogenase family
N4T37_RS20715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N4T37_RS20720	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N4T37_RS20725	COG2267	carboxylic ester hydrolase activity
N4T37_RS20745	COG3038	cytochrome b561
N4T37_RS20750	COG0753	catalase activity
N4T37_RS20780	COG2050	protein possibly involved in aromatic compounds catabolism
N4T37_RS20790	COG3327	negative regulation of DNA-templated transcription, initiation
N4T37_RS20795	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
N4T37_RS20800	COG0183	Belongs to the thiolase family
N4T37_RS20805	COG1250	3-hydroxyacyl-CoA dehydrogenase
N4T37_RS20810	COG1024	Enoyl-CoA hydratase
N4T37_RS20815	COG1024	Enoyl-CoA hydratase
N4T37_RS20820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N4T37_RS20825	COG2151	metal-sulfur cluster biosynthetic enzyme
N4T37_RS20830	COG3396	Phenylacetate-CoA oxygenase
N4T37_RS20835	COG3460	Phenylacetate-CoA oxygenase
N4T37_RS20840	COG3396	Phenylacetate-CoA oxygenase
N4T37_RS20845	COG1012	belongs to the aldehyde dehydrogenase family
N4T37_RS20845	COG2030	dehydratase
N4T37_RS20850	COG1760	l-serine dehydratase
N4T37_RS20855	COG0531	amino acid
N4T37_RS20860	COG1012	belongs to the aldehyde dehydrogenase family
N4T37_RS20885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N4T37_RS20905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N4T37_RS20915	COG0789	Transcriptional regulator
N4T37_RS20925	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N4T37_RS20940	COG2807	transmembrane transport
N4T37_RS20945	COG0590	tRNA wobble adenosine to inosine editing
N4T37_RS21065	COG1116	anion transmembrane transporter activity
N4T37_RS21070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N4T37_RS21080	COG0864	Transcriptional regulator
N4T37_RS21090	COG1733	regulation of RNA biosynthetic process
N4T37_RS21095	COG2249	NAD(P)H dehydrogenase (quinone) activity
N4T37_RS21100	COG0439	Biotin carboxylase
N4T37_RS21115	COG1063	alcohol dehydrogenase
N4T37_RS21140	COG0038	chloride channel
N4T37_RS21145	COG4770	biotin carboxylase activity
N4T37_RS21165	COG1914	H( )-stimulated, divalent metal cation uptake system
N4T37_RS21170	COG0583	DNA-binding transcription factor activity
N4T37_RS21205	COG2826	transposase and inactivated derivatives, IS30 family
N4T37_RS21275	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
N4T37_RS21300	COG2814	Major facilitator Superfamily
N4T37_RS21315	COG1560	Kdo2-lipid A biosynthetic process
N4T37_RS21325	COG5006	permease, DMT superfamily
N4T37_RS21330	COG1522	sequence-specific DNA binding
N4T37_RS21345	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
N4T37_RS21355	COG4122	O-methyltransferase activity
N4T37_RS21385	COG1538	Outer membrane efflux protein
N4T37_RS21390	COG1137	ATPase activity
N4T37_RS21395	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
N4T37_RS21405	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
N4T37_RS21630	COG5377	YqaJ viral recombinase family
N4T37_RS21640	COG0210	DNA helicase
N4T37_RS21700	COG2814	Major facilitator Superfamily
N4T37_RS21740	COG1278	Cold shock
N4T37_RS21745	COG1280	lysine exporter protein (LysE YggA)
N4T37_RS21775	COG1570	exodeoxyribonuclease VII activity
N4T37_RS21860	COG2871	sodium ion transport
N4T37_RS21870	COG0583	DNA-binding transcription factor activity
N4T37_RS21880	COG4638	Rieske (2fe-2S)
N4T37_RS21890	COG0633	Ferredoxin
N4T37_RS21890	COG0543	2 iron, 2 sulfur cluster binding
N4T37_RS21895	COG1028	Short-chain dehydrogenase reductase Sdr
N4T37_RS21900	COG3135	benzoate transporter
N4T37_RS21905	COG2814	Major facilitator Superfamily
N4T37_RS21920	COG1643	Atp-dependent helicase
N4T37_RS21925	COG0450	alkyl hydroperoxide reductase
N4T37_RS21935	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N4T37_RS21945	COG3634	alkyl hydroperoxide reductase activity
N4T37_RS21965	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N4T37_RS21970	COG0625	glutathione transferase activity
N4T37_RS21980	COG2885	chlorophyll binding
N4T37_RS22015	COG0542	response to heat
N4T37_RS22030	COG1765	OsmC-like protein
N4T37_RS22045	COG0667	Aldo Keto reductase
N4T37_RS22060	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N4T37_RS22070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N4T37_RS22080	COG0582	viral genome integration into host DNA
N4T37_RS22150	COG0739	heme binding
N4T37_RS22175	COG1598	PFAM Uncharacterised protein family UPF0150