locus-tag	class	description
NE421_RS00010	COG0592	DNA-directed DNA polymerase activity
NE421_RS00020	COG0187	DNA topoisomerase II activity
NE421_RS00030	COG0586	Pfam SNARE associated Golgi protein
NE421_RS00035	COG0488	(ABC) transporter
NE421_RS00060	COG0596	Alpha beta hydrolase
NE421_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NE421_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NE421_RS00110	COG1047	Peptidyl-prolyl cis-trans
NE421_RS00120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NE421_RS00125	COG0196	riboflavin kinase activity
NE421_RS00135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NE421_RS00140	COG1309	transcriptional regulator
NE421_RS00145	COG1116	anion transmembrane transporter activity
NE421_RS00150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NE421_RS00155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NE421_RS00160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NE421_RS00165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NE421_RS00185	COG1028	Short-chain dehydrogenase reductase Sdr
NE421_RS00190	COG0546	phosphoglycolate phosphatase activity
NE421_RS00245	COG3023	N-Acetylmuramoyl-L-alanine amidase
NE421_RS00250	COG0728	peptidoglycan biosynthetic process
NE421_RS00275	COG1596	polysaccharide export
NE421_RS00280	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NE421_RS00290	COG1216	Glycosyl transferase, family 2
NE421_RS00290	COG1442	glycosyl transferase family 8
NE421_RS00300	COG1216	Glycosyl transferase, family 2
NE421_RS00310	COG1216	Glycosyl transferase, family 2
NE421_RS00315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NE421_RS00320	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NE421_RS00335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NE421_RS00345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NE421_RS00355	COG2186	Transcriptional regulator
NE421_RS00365	COG0277	FAD linked oxidase domain protein
NE421_RS00370	COG1448	Aminotransferase
NE421_RS00380	COG1802	Transcriptional regulator
NE421_RS00395	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NE421_RS00500	COG0564	pseudouridine synthase activity
NE421_RS00540	COG0251	oxidation-reduction process
NE421_RS00545	COG1113	amino acid transport
NE421_RS00550	COG1113	amino acid transport
NE421_RS00570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NE421_RS00575	COG1960	acyl-CoA dehydrogenase activity
NE421_RS00580	COG1024	Enoyl-CoA hydratase
NE421_RS00585	COG1024	Enoyl-CoA hydratase
NE421_RS00590	COG0477	Major facilitator Superfamily
NE421_RS00595	COG3916	Acyl-homoserine-lactone synthase
NE421_RS00605	COG2197	response regulator
NE421_RS00615	COG1960	acyl-CoA dehydrogenase activity
NE421_RS00620	COG3321	synthase
NE421_RS00620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NE421_RS00620	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NE421_RS00620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NE421_RS00660	COG0271	Belongs to the BolA IbaG family
NE421_RS00670	COG1192	Involved in chromosome partitioning
NE421_RS00685	COG0586	Pfam SNARE associated Golgi protein
NE421_RS00690	COG2259	Doxx family
NE421_RS00695	COG4399	Belongs to the UPF0754 family
NE421_RS00700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NE421_RS00700	COG0519	Catalyzes the synthesis of GMP from XMP
NE421_RS00745	COG0281	malic enzyme
NE421_RS00750	COG2837	iron assimilation
NE421_RS00755	COG1280	lysine exporter protein (LysE YggA)
NE421_RS00760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NE421_RS00765	COG1121	(ABC) transporter
NE421_RS00830	COG0386	Belongs to the glutathione peroxidase family
NE421_RS00845	COG1309	transcriptional regulator
NE421_RS00850	COG0697	spore germination
NE421_RS00860	COG0758	DNA mediated transformation
NE421_RS00930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NE421_RS00940	COG0655	NAD(P)H dehydrogenase (quinone) activity
NE421_RS00980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NE421_RS00990	COG0477	Major facilitator Superfamily
NE421_RS01000	COG1253	flavin adenine dinucleotide binding
NE421_RS01010	COG2860	membrane
NE421_RS01015	COG0477	Major facilitator Superfamily
NE421_RS01025	COG0318	PFAM AMP-dependent synthetase and ligase
NE421_RS01040	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NE421_RS01060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NE421_RS01075	COG0606	chelatase, subunit chli
NE421_RS01085	COG0347	Belongs to the P(II) protein family
NE421_RS01090	COG0004	ammonium transporteR
NE421_RS01100	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NE421_RS01100	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NE421_RS01140	COG0795	lipopolysaccharide-transporting ATPase activity
NE421_RS01145	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NE421_RS01150	COG0793	Belongs to the peptidase S41A family
NE421_RS01165	COG2197	response regulator
NE421_RS01175	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NE421_RS01185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NE421_RS01190	COG4974	Belongs to the 'phage' integrase family
NE421_RS01215	COG0772	Belongs to the SEDS family
NE421_RS01220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NE421_RS01225	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NE421_RS01230	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NE421_RS01255	COG0697	spore germination
NE421_RS01260	COG1538	Outer membrane efflux protein
NE421_RS01280	COG3275	phosphorelay sensor kinase activity
NE421_RS01290	COG0181	hydroxymethylbilane synthase activity
NE421_RS01335	COG1716	ATPase activity
NE421_RS01340	COG0546	phosphoglycolate phosphatase activity
NE421_RS01440	COG2056	Na+-H+ antiporter family
NE421_RS01455	COG0326	Molecular chaperone. Has ATPase activity
NE421_RS01470	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NE421_RS01540	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NE421_RS01545	COG2169	Transcriptional regulator
NE421_RS01545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NE421_RS01575	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NE421_RS01585	COG0497	DNA recombination
NE421_RS01600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NE421_RS01610	COG0237	dephospho-CoA kinase activity
NE421_RS01615	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NE421_RS01665	COG0195	Participates in both transcription termination and antitermination
NE421_RS01680	COG1320	monovalent cation:proton antiporter activity
NE421_RS01685	COG2212	antiporter activity
NE421_RS01690	COG1863	multisubunit Na H antiporter MnhE subunit
NE421_RS01695	COG0651	ATP synthesis coupled electron transport
NE421_RS01700	COG1006	Multisubunit Na H antiporter MnhC subunit
NE421_RS01705	COG2111	Na H antiporter
NE421_RS01705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NE421_RS01720	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NE421_RS01730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NE421_RS01735	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NE421_RS01745	COG2226	methyltransferase
NE421_RS01765	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NE421_RS01770	COG1074	ATP-dependent DNA helicase activity
NE421_RS01775	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NE421_RS01780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NE421_RS01795	COG0598	Magnesium transport protein CorA
NE421_RS01800	COG0789	Transcriptional regulator
NE421_RS01805	COG0484	heat shock protein binding
NE421_RS01820	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NE421_RS01820	COG0475	glutathione-regulated potassium exporter activity
NE421_RS01825	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NE421_RS01845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NE421_RS01855	COG4535	Mg2 and Co2 transporter CorC
NE421_RS01860	COG0425	Belongs to the sulfur carrier protein TusA family
NE421_RS01870	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
NE421_RS01870	COG0644	oxidoreductase
NE421_RS01880	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NE421_RS01895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NE421_RS01900	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NE421_RS01940	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NE421_RS01955	COG0534	Mate efflux family protein
NE421_RS01965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NE421_RS01970	COG4221	oxidoreductase activity
NE421_RS01975	COG0583	DNA-binding transcription factor activity
NE421_RS01990	COG0318	PFAM AMP-dependent synthetase and ligase
NE421_RS01995	COG1530	ribonuclease E activity
NE421_RS02005	COG0546	phosphoglycolate phosphatase activity
NE421_RS02010	COG2378	regulation of single-species biofilm formation
NE421_RS02015	COG0625	glutathione transferase activity
NE421_RS02025	COG0583	DNA-binding transcription factor activity
NE421_RS02080	COG0473	3-isopropylmalate dehydrogenase activity
NE421_RS02135	COG1301	dicarboxylic acid transport
NE421_RS02145	COG1560	Kdo2-lipid A biosynthetic process
NE421_RS02150	COG1280	lysine exporter protein (LysE YggA)
NE421_RS02160	COG0488	(ABC) transporter
NE421_RS02165	COG2900	Belongs to the SlyX family
NE421_RS02175	COG1733	regulation of RNA biosynthetic process
NE421_RS02200	COG0210	DNA helicase
NE421_RS02205	COG0724	RNA recognition motif
NE421_RS02225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NE421_RS02225	COG4651	solute:proton antiporter activity
NE421_RS02250	COG0788	formyltetrahydrofolate deformylase activity
NE421_RS02400	COG2813	Specifically methylates the guanine in position
NE421_RS02400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NE421_RS02410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NE421_RS02420	COG4774	siderophore transport
NE421_RS02430	COG0740	serine-type endopeptidase activity
NE421_RS02450	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NE421_RS02450	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
NE421_RS02455	COG0280	phosphate acetyltransferase
NE421_RS02455	COG0857	belongs to the CobB CobQ family
NE421_RS02460	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NE421_RS02470	COG0800	Aldolase
NE421_RS02480	COG3265	gluconokinase activity
NE421_RS02485	COG1012	belongs to the aldehyde dehydrogenase family
NE421_RS02495	COG2267	carboxylic ester hydrolase activity
NE421_RS02510	COG0793	Belongs to the peptidase S41A family
NE421_RS02545	COG1426	Protein conserved in bacteria
NE421_RS02585	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NE421_RS02595	COG1162	GTPase activity
NE421_RS02600	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NE421_RS02615	COG1538	Outer membrane efflux protein
NE421_RS02620	COG1136	(ABC) transporter
NE421_RS02620	COG0577	efflux transmembrane transporter activity
NE421_RS02625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NE421_RS02650	COG0028	Belongs to the TPP enzyme family
NE421_RS02655	COG0440	acetolactate synthase activity
NE421_RS02850	COG4221	oxidoreductase activity
NE421_RS02855	COG0583	DNA-binding transcription factor activity
NE421_RS02860	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
NE421_RS02880	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NE421_RS02890	COG1979	alcohol dehydrogenase
NE421_RS02910	COG1309	transcriptional regulator
NE421_RS02915	COG2130	NADP-dependent
NE421_RS02940	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NE421_RS02955	COG0084	hydrolase, TatD family'
NE421_RS02965	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NE421_RS02975	COG0583	DNA-binding transcription factor activity
NE421_RS02985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NE421_RS03070	COG2205	protein histidine kinase activity
NE421_RS03085	COG2132	Multicopper oxidase
NE421_RS03110	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NE421_RS03145	COG0640	Transcriptional regulator
NE421_RS03155	COG0798	PFAM Bile acid sodium symporter
NE421_RS03160	COG0431	NADPH-dependent FMN reductase
NE421_RS03165	COG0492	ferredoxin-NADP+ reductase activity
NE421_RS03170	COG2072	flavoprotein involved in K transport
NE421_RS03195	COG2814	Major facilitator Superfamily
NE421_RS03205	COG0697	spore germination
NE421_RS03235	COG3622	Belongs to the hyi family
NE421_RS03240	COG2084	Dehydrogenase
NE421_RS03245	COG1024	Enoyl-CoA hydratase
NE421_RS03250	COG0784	Response regulator, receiver
NE421_RS03250	COG2205	protein histidine kinase activity
NE421_RS03250	COG5002	protein histidine kinase activity
NE421_RS03270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NE421_RS03280	COG3956	TIGRFAM MazG family protein
NE421_RS03285	COG1555	photosystem II stabilization
NE421_RS03290	COG0617	tRNA 3'-terminal CCA addition
NE421_RS03295	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NE421_RS03315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NE421_RS03320	COG3028	Belongs to the UPF0307 family
NE421_RS03325	COG0318	PFAM AMP-dependent synthetase and ligase
NE421_RS03340	COG0625	glutathione transferase activity
NE421_RS03345	COG1238	metal cluster binding
NE421_RS03390	COG0072	phenylalanine-tRNA ligase activity
NE421_RS03420	COG0248	Ppx GppA phosphatase
NE421_RS03430	COG0037	tRNA processing
NE421_RS03470	COG1764	response to oxidative stress
NE421_RS03475	COG1846	Transcriptional regulator
NE421_RS03485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NE421_RS03545	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NE421_RS03550	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NE421_RS03555	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NE421_RS03565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NE421_RS03570	COG1388	LysM domain
NE421_RS03570	COG1134	teichoic acid transport
NE421_RS03615	COG1214	PFAM Peptidase M22, glycoprotease
NE421_RS03640	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NE421_RS03645	COG0561	phosphatase activity
NE421_RS03655	COG2132	Multicopper oxidase
NE421_RS03675	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NE421_RS03680	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NE421_RS03685	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NE421_RS03715	COG1063	alcohol dehydrogenase
NE421_RS03720	COG0583	DNA-binding transcription factor activity
NE421_RS03725	COG1960	acyl-CoA dehydrogenase activity
NE421_RS03730	COG2814	Major facilitator Superfamily
NE421_RS03735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NE421_RS03745	COG1053	succinate dehydrogenase
NE421_RS03750	COG0583	DNA-binding transcription factor activity
NE421_RS03765	COG0583	DNA-binding transcription factor activity
NE421_RS03810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NE421_RS03820	COG5290	Psort location Cytoplasmic, score
NE421_RS03845	COG0384	phenazine biosynthesis protein PhzF
NE421_RS03905	COG3621	Patatin-like phospholipase
NE421_RS03940	COG1028	Short-chain dehydrogenase reductase Sdr
NE421_RS03955	COG2271	Major facilitator Superfamily
NE421_RS03990	COG0697	spore germination
NE421_RS04000	COG0583	DNA-binding transcription factor activity
NE421_RS04005	COG1301	dicarboxylic acid transport
NE421_RS04015	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NE421_RS04035	COG0745	RESPONSE REGULATOR receiver
NE421_RS04075	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NE421_RS04105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NE421_RS04110	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NE421_RS04130	COG0583	DNA-binding transcription factor activity
NE421_RS04150	COG0668	transmembrane transport
NE421_RS04160	COG2081	HI0933 family
NE421_RS04165	COG2515	1-aminocyclopropane-1-carboxylate deaminase
NE421_RS04195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NE421_RS04195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NE421_RS04205	COG0489	protein tyrosine kinase activity
NE421_RS04255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NE421_RS04265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NE421_RS04280	COG0730	response to heat
NE421_RS04290	COG1196	nuclear chromosome segregation
NE421_RS04310	COG2223	nitrite transmembrane transporter activity
NE421_RS04315	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
NE421_RS04320	COG1877	trehalose-phosphatase activity
NE421_RS04325	COG0596	Alpha beta hydrolase
NE421_RS04325	COG2226	methyltransferase
NE421_RS04325	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NE421_RS04340	COG4106	trans-aconitate 2-methyltransferase activity
NE421_RS04355	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NE421_RS04360	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NE421_RS04365	COG0009	L-threonylcarbamoyladenylate synthase
NE421_RS04370	COG3101	peptidyl-lysine hydroxylation
NE421_RS04375	COG1399	metal-binding, possibly nucleic acid-binding protein
NE421_RS04400	COG1652	LysM domain
NE421_RS04405	COG0351	phosphomethylpyrimidine kinase
NE421_RS04405	COG0352	thiamine-phosphate diphosphorylase activity
NE421_RS04405	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NE421_RS04415	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NE421_RS04445	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NE421_RS04475	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NE421_RS04490	COG0358	DNA primase activity
NE421_RS04500	COG0564	pseudouridine synthase activity
NE421_RS04755	COG3646	Phage regulatory protein
NE421_RS04860	COG0582	viral genome integration into host DNA
NE421_RS04870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NE421_RS04890	COG0583	DNA-binding transcription factor activity
NE421_RS04895	COG0473	3-isopropylmalate dehydrogenase activity
NE421_RS04905	COG0657	acetylesterase activity
NE421_RS04915	COG1012	belongs to the aldehyde dehydrogenase family
NE421_RS04935	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NE421_RS04935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NE421_RS04950	COG1981	membrane
NE421_RS04995	COG0456	acetyltransferase
NE421_RS05005	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NE421_RS05010	COG0492	ferredoxin-NADP+ reductase activity
NE421_RS05015	COG1674	ftsk spoiiie
NE421_RS05015	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NE421_RS05020	COG1280	lysine exporter protein (LysE YggA)
NE421_RS05035	COG2894	cell division
NE421_RS05050	COG0204	Acyl-transferase
NE421_RS05055	COG2885	chlorophyll binding
NE421_RS05060	COG0210	DNA helicase
NE421_RS05070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NE421_RS05085	COG0121	glutamine amidotransferase
NE421_RS05105	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NE421_RS05110	COG0735	belongs to the Fur family
NE421_RS05135	COG0420	3'-5' exonuclease activity
NE421_RS05155	COG1090	epimerase
NE421_RS05170	COG2050	protein possibly involved in aromatic compounds catabolism
NE421_RS05175	COG1566	PFAM secretion protein HlyD family protein
NE421_RS05180	COG2814	Major facilitator Superfamily
NE421_RS05185	COG0405	Gamma-glutamyltransferase
NE421_RS05195	COG0582	viral genome integration into host DNA
NE421_RS05225	COG0531	amino acid
NE421_RS05230	COG2040	homocysteine
NE421_RS05255	COG1309	transcriptional regulator
NE421_RS05260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NE421_RS05265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NE421_RS05275	COG1607	acyl-coa hydrolase
NE421_RS05285	COG0523	cobalamin synthesis protein
NE421_RS05295	COG4681	YaeQ
NE421_RS05305	COG1649	PFAM Uncharacterised BCR, COG1649
NE421_RS05305	COG0726	polysaccharide deacetylase
NE421_RS05310	COG1215	transferase activity, transferring glycosyl groups
NE421_RS05320	COG1024	Enoyl-CoA hydratase
NE421_RS05335	COG1414	Transcriptional regulator
NE421_RS05370	COG2271	Major facilitator Superfamily
NE421_RS05380	COG2267	carboxylic ester hydrolase activity
NE421_RS05385	COG1028	Short-chain dehydrogenase reductase Sdr
NE421_RS05400	COG0028	Belongs to the TPP enzyme family
NE421_RS05410	COG0477	Major facilitator Superfamily
NE421_RS05415	COG0242	peptide deformylase activity
NE421_RS05420	COG2066	Belongs to the glutaminase family
NE421_RS05425	COG2207	Transcriptional regulator
NE421_RS05430	COG2223	nitrite transmembrane transporter activity
NE421_RS05445	COG0583	DNA-binding transcription factor activity
NE421_RS05450	COG1028	Short-chain dehydrogenase reductase Sdr
NE421_RS05455	COG2271	Major facilitator Superfamily
NE421_RS05460	COG3959	Transketolase, thiamine diphosphate binding domain
NE421_RS05465	COG3958	Transketolase
NE421_RS05475	COG0306	phosphate transporter
NE421_RS05495	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NE421_RS05540	COG4181	ATPase activity
NE421_RS05545	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
NE421_RS05575	COG0583	DNA-binding transcription factor activity
NE421_RS05585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NE421_RS05590	COG1773	rubredoxin
NE421_RS05640	COG2851	Citrate transporter
NE421_RS05645	COG1253	flavin adenine dinucleotide binding
NE421_RS05685	COG0804	urea catabolic process
NE421_RS05695	COG0830	nickel cation binding
NE421_RS05710	COG0742	ribosomal rna small subunit methyltransferase
NE421_RS05715	COG0768	penicillin binding
NE421_RS05740	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NE421_RS05745	COG2878	Part of a membrane complex involved in electron transport
NE421_RS05750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NE421_RS05760	COG3384	dioxygenase
NE421_RS05775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NE421_RS05815	COG0006	proline dipeptidase activity
NE421_RS05820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NE421_RS05825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NE421_RS05845	COG1279	arginine transmembrane transporter activity
NE421_RS05850	COG0583	DNA-binding transcription factor activity
NE421_RS05890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NE421_RS05895	COG1388	LysM domain
NE421_RS05895	COG0741	lytic transglycosylase activity
NE421_RS05895	COG1388	LysM domain
NE421_RS05895	COG0741	lytic transglycosylase activity
NE421_RS05905	COG4174	ABC transporter (Permease)
NE421_RS05910	COG4239	(ABC) transporter, permease
NE421_RS05915	COG4172	Belongs to the ABC transporter superfamily
NE421_RS05935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NE421_RS05945	COG5001	Diguanylate cyclase
NE421_RS05945	COG4251	negative regulation of phosphorylation
NE421_RS05945	COG3706	GGDEF domain
NE421_RS05945	COG2203	Gaf domain
NE421_RS05955	COG1902	pentaerythritol trinitrate reductase activity
NE421_RS05955	COG0446	pyridine nucleotide-disulphide oxidoreductase
NE421_RS05965	COG0582	viral genome integration into host DNA
NE421_RS06075	COG2814	Major facilitator Superfamily
NE421_RS06090	COG1230	cation diffusion facilitator family transporter
NE421_RS06100	COG2059	Chromate
NE421_RS06135	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NE421_RS06145	COG0583	DNA-binding transcription factor activity
NE421_RS06150	COG2814	Major facilitator Superfamily
NE421_RS06170	COG1012	belongs to the aldehyde dehydrogenase family
NE421_RS06175	COG1454	alcohol dehydrogenase
NE421_RS06180	COG3485	protocatechuate 3,4-dioxygenase
NE421_RS06195	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NE421_RS06200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NE421_RS06205	COG0183	Belongs to the thiolase family
NE421_RS06240	COG1113	amino acid transport
NE421_RS06250	COG0531	amino acid
NE421_RS06270	COG1012	belongs to the aldehyde dehydrogenase family
NE421_RS06290	COG1113	amino acid transport
NE421_RS06305	COG0697	spore germination
NE421_RS06310	COG2721	sulfolactate sulfo-lyase activity
NE421_RS06315	COG2271	Major facilitator Superfamily
NE421_RS06320	COG4948	Mandelate Racemase Muconate Lactonizing
NE421_RS06330	COG1012	belongs to the aldehyde dehydrogenase family
NE421_RS06335	COG2186	Transcriptional regulator
NE421_RS06360	COG1960	acyl-CoA dehydrogenase activity
NE421_RS06370	COG1012	belongs to the aldehyde dehydrogenase family
NE421_RS06375	COG1024	Enoyl-CoA hydratase
NE421_RS06380	COG2814	Major facilitator Superfamily
NE421_RS06395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NE421_RS06410	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NE421_RS06450	COG2207	Transcriptional regulator
NE421_RS06455	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NE421_RS06470	COG0583	DNA-binding transcription factor activity
NE421_RS06475	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NE421_RS06480	COG2072	flavoprotein involved in K transport
NE421_RS06485	COG0300	oxidoreductase activity
NE421_RS06495	COG1309	transcriptional regulator
NE421_RS06500	COG1741	Belongs to the pirin family
NE421_RS06515	COG2072	flavoprotein involved in K transport
NE421_RS06525	COG2252	PERMEase
NE421_RS06530	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NE421_RS06535	COG3038	cytochrome b561
NE421_RS06545	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NE421_RS06555	COG0527	aspartate kinase activity
NE421_RS06565	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NE421_RS06575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NE421_RS06590	COG0667	Aldo Keto reductase
NE421_RS06605	COG1765	OsmC-like protein
NE421_RS06620	COG0542	response to heat
NE421_RS06655	COG2885	chlorophyll binding
NE421_RS06665	COG0625	glutathione transferase activity
NE421_RS06670	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NE421_RS06690	COG3634	alkyl hydroperoxide reductase activity
NE421_RS06700	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NE421_RS06710	COG0450	alkyl hydroperoxide reductase
NE421_RS06715	COG1643	Atp-dependent helicase
NE421_RS06730	COG2814	Major facilitator Superfamily
NE421_RS06735	COG3135	benzoate transporter
NE421_RS06740	COG1028	Short-chain dehydrogenase reductase Sdr
NE421_RS06745	COG0633	Ferredoxin
NE421_RS06745	COG0543	2 iron, 2 sulfur cluster binding
NE421_RS06755	COG4638	Rieske (2fe-2S)
NE421_RS06765	COG0583	DNA-binding transcription factor activity
NE421_RS06775	COG2871	sodium ion transport
NE421_RS06860	COG1570	exodeoxyribonuclease VII activity
NE421_RS06890	COG1280	lysine exporter protein (LysE YggA)
NE421_RS06895	COG1278	Cold shock
NE421_RS06930	COG2814	Major facilitator Superfamily
NE421_RS06995	COG0517	IMP dehydrogenase activity
NE421_RS06995	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NE421_RS07000	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NE421_RS07010	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NE421_RS07015	COG1137	ATPase activity
NE421_RS07025	COG1538	Outer membrane efflux protein
NE421_RS07055	COG4122	O-methyltransferase activity
NE421_RS07065	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NE421_RS07080	COG1522	sequence-specific DNA binding
NE421_RS07085	COG5006	permease, DMT superfamily
NE421_RS07095	COG1560	Kdo2-lipid A biosynthetic process
NE421_RS07110	COG2814	Major facilitator Superfamily
NE421_RS07130	COG1250	3-hydroxyacyl-CoA dehydrogenase
NE421_RS07150	COG0583	DNA-binding transcription factor activity
NE421_RS07155	COG1914	H( )-stimulated, divalent metal cation uptake system
NE421_RS07175	COG4770	biotin carboxylase activity
NE421_RS07180	COG0038	chloride channel
NE421_RS07185	COG2831	hemolysin activation secretion protein
NE421_RS07190	COG3210	domain, Protein
NE421_RS07200	COG1309	transcriptional regulator
NE421_RS07210	COG1063	alcohol dehydrogenase
NE421_RS07225	COG0439	Biotin carboxylase
NE421_RS07230	COG2249	NAD(P)H dehydrogenase (quinone) activity
NE421_RS07235	COG1733	regulation of RNA biosynthetic process
NE421_RS07245	COG0864	Transcriptional regulator
NE421_RS07255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NE421_RS07260	COG1116	anion transmembrane transporter activity
NE421_RS07420	COG0590	tRNA wobble adenosine to inosine editing
NE421_RS07425	COG2807	transmembrane transport
NE421_RS07440	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NE421_RS07450	COG0789	Transcriptional regulator
NE421_RS07460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NE421_RS07480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NE421_RS07505	COG1012	belongs to the aldehyde dehydrogenase family
NE421_RS07510	COG0531	amino acid
NE421_RS07515	COG1760	l-serine dehydratase
NE421_RS07520	COG1012	belongs to the aldehyde dehydrogenase family
NE421_RS07520	COG2030	dehydratase
NE421_RS07525	COG3396	Phenylacetate-CoA oxygenase
NE421_RS07530	COG3460	Phenylacetate-CoA oxygenase
NE421_RS07535	COG3396	Phenylacetate-CoA oxygenase
NE421_RS07540	COG2151	metal-sulfur cluster biosynthetic enzyme
NE421_RS07545	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NE421_RS07550	COG1024	Enoyl-CoA hydratase
NE421_RS07555	COG1024	Enoyl-CoA hydratase
NE421_RS07560	COG1250	3-hydroxyacyl-CoA dehydrogenase
NE421_RS07565	COG0183	Belongs to the thiolase family
NE421_RS07570	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
NE421_RS07575	COG3327	negative regulation of DNA-templated transcription, initiation
NE421_RS07585	COG2050	protein possibly involved in aromatic compounds catabolism
NE421_RS07605	COG0753	catalase activity
NE421_RS07610	COG3038	cytochrome b561
NE421_RS07630	COG2267	carboxylic ester hydrolase activity
NE421_RS07635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NE421_RS07640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NE421_RS07645	COG1012	belongs to the aldehyde dehydrogenase family
NE421_RS07655	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NE421_RS07665	COG1012	belongs to the aldehyde dehydrogenase family
NE421_RS07670	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NE421_RS07675	COG0583	DNA-binding transcription factor activity
NE421_RS07685	COG1414	Transcriptional regulator
NE421_RS07690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NE421_RS07700	COG1840	ABC-type Fe3 transport system, periplasmic component
NE421_RS07705	COG3842	ATPase activity
NE421_RS07720	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NE421_RS07725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NE421_RS07730	COG2814	Major facilitator Superfamily
NE421_RS07735	COG1960	acyl-CoA dehydrogenase activity
NE421_RS07750	COG1024	Enoyl-CoA hydratase
NE421_RS07760	COG2814	Major facilitator Superfamily
NE421_RS07770	COG0183	Belongs to the thiolase family
NE421_RS07775	COG1250	3-hydroxyacyl-CoA dehydrogenase
NE421_RS07780	COG1028	Short-chain dehydrogenase reductase Sdr
NE421_RS07785	COG1024	Enoyl-CoA hydratase
NE421_RS07790	COG1960	acyl-CoA dehydrogenase activity
NE421_RS07795	COG2814	Major facilitator Superfamily
NE421_RS07800	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NE421_RS07805	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NE421_RS07815	COG2814	Major facilitator Superfamily
NE421_RS07825	COG1960	acyl-CoA dehydrogenase activity
NE421_RS07840	COG0583	DNA-binding transcription factor activity
NE421_RS07850	COG4770	biotin carboxylase activity
NE421_RS07855	COG1024	Enoyl-CoA hydratase
NE421_RS07860	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NE421_RS07865	COG1960	acyl-CoA dehydrogenase activity
NE421_RS07870	COG1309	transcriptional regulator
NE421_RS07875	COG0318	PFAM AMP-dependent synthetase and ligase
NE421_RS07895	COG0583	DNA-binding transcription factor activity
NE421_RS07945	COG1028	Short-chain dehydrogenase reductase Sdr
NE421_RS07965	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NE421_RS07985	COG2205	protein histidine kinase activity
NE421_RS07985	COG0784	Response regulator, receiver
NE421_RS08005	COG0765	amino acid transport
NE421_RS08010	COG0765	amino acid transport
NE421_RS08015	COG1126	abc transporter atp-binding protein
NE421_RS08020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NE421_RS08025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NE421_RS08040	COG1280	lysine exporter protein (LysE YggA)
NE421_RS08050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NE421_RS08055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NE421_RS08060	COG1045	serine acetyltransferase
NE421_RS08075	COG0583	DNA-binding transcription factor activity
NE421_RS08080	COG0625	glutathione transferase activity
NE421_RS08085	COG0625	glutathione transferase activity
NE421_RS08090	COG0583	DNA-binding transcription factor activity
NE421_RS08100	COG1346	cytolysis
NE421_RS08105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NE421_RS08125	COG0300	oxidoreductase activity
NE421_RS08135	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
NE421_RS08140	COG3052	prosthetic group binding
NE421_RS08160	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NE421_RS08180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NE421_RS08190	COG1294	oxidase, subunit
NE421_RS08195	COG1271	oxidase subunit
NE421_RS08215	COG0477	Major facilitator Superfamily
NE421_RS08225	COG4521	taurine ABC transporter
NE421_RS08230	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NE421_RS08235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NE421_RS08240	COG2175	clavaminate synthase activity
NE421_RS08250	COG1953	Uracil, thiamine, allantoin
NE421_RS08260	COG0583	DNA-binding transcription factor activity
NE421_RS08285	COG0640	Transcriptional regulator
NE421_RS08290	COG0798	PFAM Bile acid sodium symporter
NE421_RS08295	COG0583	DNA-binding transcription factor activity
NE421_RS08310	COG3634	alkyl hydroperoxide reductase activity
NE421_RS08345	COG1301	dicarboxylic acid transport
NE421_RS08350	COG0436	Aminotransferase
NE421_RS08360	COG0386	Belongs to the glutathione peroxidase family
NE421_RS08400	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NE421_RS08425	COG0012	GTP binding
NE421_RS08430	COG2011	ABC-type metal ion transport system permease component
NE421_RS08435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NE421_RS08445	COG1464	Belongs to the NlpA lipoprotein family
NE421_RS08475	COG0765	amino acid transport
NE421_RS08480	COG0765	amino acid transport
NE421_RS08485	COG1126	abc transporter atp-binding protein
NE421_RS08495	COG1522	sequence-specific DNA binding
NE421_RS08510	COG1309	transcriptional regulator
NE421_RS08530	COG0583	DNA-binding transcription factor activity
NE421_RS08540	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NE421_RS08550	COG0697	spore germination
NE421_RS08575	COG3121	Chaperone
NE421_RS08580	COG3539	Fimbrial protein
NE421_RS08605	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NE421_RS08605	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NE421_RS08650	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NE421_RS08660	COG2353	YceI-like domain
NE421_RS08670	COG3698	Phosphodiester glycosidase
NE421_RS08685	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NE421_RS08690	COG0506	proline dehydrogenase activity
NE421_RS08690	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NE421_RS08690	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NE421_RS08700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NE421_RS08705	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NE421_RS08725	COG1132	(ABC) transporter
NE421_RS08730	COG3122	Protein conserved in bacteria
NE421_RS08735	COG3619	membrane
NE421_RS08745	COG0640	Transcriptional regulator
NE421_RS08755	COG2850	peptidyl-arginine hydroxylation
NE421_RS08760	COG0424	maF-like protein
NE421_RS08780	COG0191	fructose-bisphosphate aldolase activity
NE421_RS08785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NE421_RS08800	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NE421_RS08810	COG1192	Involved in chromosome partitioning
NE421_RS08815	COG1475	DNA binding
NE421_RS08820	COG0811	peptide transport
NE421_RS08830	COG1132	(ABC) transporter
NE421_RS08835	COG1663	tetraacyldisaccharide 4'-kinase activity
NE421_RS08855	COG0084	hydrolase, TatD family'
NE421_RS08920	COG0776	regulation of translation
NE421_RS08950	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NE421_RS08955	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NE421_RS09005	COG0339	signal peptide processing
NE421_RS09015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NE421_RS09050	COG0702	epimerase
NE421_RS09055	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NE421_RS09075	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NE421_RS09105	COG0316	Belongs to the HesB IscA family
NE421_RS09110	COG0822	iron-sulfur transferase activity
NE421_RS09135	COG0776	regulation of translation
NE421_RS09140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NE421_RS09145	COG2207	Transcriptional regulator
NE421_RS09150	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NE421_RS09155	COG1960	acyl-CoA dehydrogenase activity
NE421_RS09160	COG1960	acyl-CoA dehydrogenase activity
NE421_RS09175	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NE421_RS09190	COG2814	Major facilitator Superfamily
NE421_RS09195	COG4264	IucA IucC family
NE421_RS09200	COG4264	IucA IucC family
NE421_RS09210	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NE421_RS09240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NE421_RS09255	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NE421_RS09260	COG0406	alpha-ribazole phosphatase activity
NE421_RS09275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NE421_RS09280	COG0730	response to heat
NE421_RS09300	COG4773	Receptor
NE421_RS09305	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NE421_RS09320	COG1131	(ABC) transporter
NE421_RS09325	COG0842	Transport permease protein
NE421_RS09330	COG0842	Transport permease protein
NE421_RS09385	COG2226	methyltransferase
NE421_RS09410	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NE421_RS09445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NE421_RS09455	COG0133	tryptophan synthase activity
NE421_RS09470	COG3706	GGDEF domain
NE421_RS09485	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NE421_RS09490	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NE421_RS09495	COG0022	dehydrogenase e1 component
NE421_RS09500	COG0508	dehydrogenase complex catalyzes the overall conversion of
NE421_RS09505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NE421_RS09515	COG1063	alcohol dehydrogenase
NE421_RS09520	COG3781	membrane
NE421_RS09530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NE421_RS09530	COG3453	Protein conserved in bacteria
NE421_RS09545	COG0730	response to heat
NE421_RS09560	COG2207	Transcriptional regulator
NE421_RS09560	COG3708	Transcriptional regulator
NE421_RS09565	COG1733	regulation of RNA biosynthetic process
NE421_RS09570	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NE421_RS09580	COG2188	Transcriptional regulator
NE421_RS09595	COG4521	taurine ABC transporter
NE421_RS09600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NE421_RS09620	COG0477	Major facilitator Superfamily
NE421_RS09630	COG1027	Aspartate ammonia-lyase
NE421_RS09645	COG0583	DNA-binding transcription factor activity
NE421_RS09650	COG0583	DNA-binding transcription factor activity
NE421_RS09655	COG0183	Belongs to the thiolase family
NE421_RS09660	COG2031	fatty acid transporter
NE421_RS09675	COG0583	DNA-binding transcription factor activity
NE421_RS09695	COG1309	transcriptional regulator
NE421_RS09705	COG2610	gluconate transmembrane transporter activity
NE421_RS09710	COG1028	Short-chain dehydrogenase reductase Sdr
NE421_RS09715	COG2207	Transcriptional regulator
NE421_RS09730	COG1028	Short-chain dehydrogenase reductase Sdr
NE421_RS09740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NE421_RS09755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NE421_RS09755	COG0543	2 iron, 2 sulfur cluster binding
NE421_RS09760	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
NE421_RS09765	COG4638	Rieske (2fe-2S)
NE421_RS09775	COG0725	ABC transporter, periplasmic molybdate-binding protein
NE421_RS09780	COG4149	molybdate abc transporter
NE421_RS09785	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NE421_RS09790	COG1028	Short-chain dehydrogenase reductase Sdr
NE421_RS09795	COG1535	isochorismatase
NE421_RS09795	COG3433	isochorismatase activity
NE421_RS09855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NE421_RS09870	COG0753	catalase activity
NE421_RS09880	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
NE421_RS09910	COG3539	Fimbrial protein
NE421_RS09935	COG0747	negative chemotaxis
NE421_RS09940	COG0601	transmembrane transport
NE421_RS09945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NE421_RS09965	COG1132	(ABC) transporter
NE421_RS09970	COG1132	(ABC) transporter
NE421_RS09990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NE421_RS10005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NE421_RS10020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NE421_RS10025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NE421_RS10030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NE421_RS10035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NE421_RS10065	COG4771	TonB-dependent receptor
NE421_RS10070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NE421_RS10190	COG2826	transposase and inactivated derivatives, IS30 family
NE421_RS10260	COG1024	Enoyl-CoA hydratase
NE421_RS10275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NE421_RS10285	COG2814	Major facilitator Superfamily
NE421_RS10295	COG0402	S-adenosylhomocysteine deaminase activity
NE421_RS10310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NE421_RS10315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NE421_RS10320	COG0745	RESPONSE REGULATOR receiver
NE421_RS10325	COG2205	protein histidine kinase activity
NE421_RS10345	COG1073	alpha beta
NE421_RS10385	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NE421_RS10435	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NE421_RS10455	COG1120	ATPase activity
NE421_RS10460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NE421_RS10470	COG1064	alcohol dehydrogenase
NE421_RS10485	COG2207	Transcriptional regulator
NE421_RS10490	COG2084	Dehydrogenase
NE421_RS10500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NE421_RS10505	COG0583	DNA-binding transcription factor activity
NE421_RS10515	COG0129	dihydroxy-acid dehydratase activity
NE421_RS10520	COG1012	belongs to the aldehyde dehydrogenase family
NE421_RS10535	COG1566	PFAM secretion protein HlyD family protein
NE421_RS10545	COG2271	Major facilitator Superfamily
NE421_RS10560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NE421_RS10585	COG0583	DNA-binding transcription factor activity
NE421_RS10600	COG2188	Transcriptional regulator
NE421_RS10660	COG1473	amidohydrolase
NE421_RS10670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NE421_RS10670	COG0475	glutathione-regulated potassium exporter activity
NE421_RS10680	COG0583	DNA-binding transcription factor activity
NE421_RS10685	COG1335	isochorismatase
NE421_RS10695	COG1309	transcriptional regulator
NE421_RS10725	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NE421_RS10740	COG1846	Transcriptional regulator
NE421_RS10775	COG1012	belongs to the aldehyde dehydrogenase family
NE421_RS10790	COG3162	membrane
NE421_RS10800	COG3829	transcription factor binding
NE421_RS10805	COG1028	Short-chain dehydrogenase reductase Sdr
NE421_RS10810	COG1960	acyl-CoA dehydrogenase activity
NE421_RS10825	COG3231	kanamycin kinase activity
NE421_RS10830	COG1012	belongs to the aldehyde dehydrogenase family
NE421_RS10850	COG2186	Transcriptional regulator
NE421_RS10860	COG0583	DNA-binding transcription factor activity
NE421_RS10865	COG4948	Mandelate Racemase Muconate Lactonizing
NE421_RS10870	COG4829	muconolactone delta-isomerase
NE421_RS10880	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NE421_RS10885	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NE421_RS10890	COG0183	Belongs to the thiolase family
NE421_RS10895	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NE421_RS10900	COG1012	belongs to the aldehyde dehydrogenase family
NE421_RS10910	COG3733	amine oxidase
NE421_RS10920	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NE421_RS10930	COG1028	Short-chain dehydrogenase reductase Sdr
NE421_RS10940	COG4638	Rieske (2fe-2S)
NE421_RS10960	COG0154	amidase activity
NE421_RS10970	COG2814	Major facilitator Superfamily
NE421_RS10995	COG1960	acyl-CoA dehydrogenase activity
NE421_RS11000	COG0583	DNA-binding transcription factor activity
NE421_RS11005	COG1414	Transcriptional regulator
NE421_RS11020	COG2391	methyltransferase activity
NE421_RS11030	COG4993	Dehydrogenase
NE421_RS11035	COG3659	wide pore channel activity
NE421_RS11040	COG3420	alginic acid biosynthetic process
NE421_RS11045	COG0710	3-dehydroquinate dehydratase activity
NE421_RS11050	COG3485	protocatechuate 3,4-dioxygenase
NE421_RS11055	COG3485	protocatechuate 3,4-dioxygenase
NE421_RS11060	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NE421_RS11065	COG2271	Major facilitator Superfamily
NE421_RS11070	COG0596	Alpha beta hydrolase
NE421_RS11075	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NE421_RS11080	COG0183	Belongs to the thiolase family
NE421_RS11085	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NE421_RS11090	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NE421_RS11100	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NE421_RS11105	COG2323	membrane
NE421_RS11150	COG0446	pyridine nucleotide-disulphide oxidoreductase
NE421_RS11150	COG1902	pentaerythritol trinitrate reductase activity
NE421_RS11175	COG0542	response to heat
NE421_RS11180	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NE421_RS11210	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NE421_RS11215	COG0569	domain protein
NE421_RS11220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NE421_RS11235	COG4774	siderophore transport
NE421_RS11240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NE421_RS11250	COG1585	Membrane protein implicated in regulation of membrane protease activity
NE421_RS11265	COG1294	oxidase, subunit
NE421_RS11270	COG4890	Cyd operon protein YbgT
NE421_RS11280	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
NE421_RS11290	COG0552	protein localization to endoplasmic reticulum
NE421_RS11315	COG0516	GMP reductase activity
NE421_RS11315	COG0517	IMP dehydrogenase activity
NE421_RS11320	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NE421_RS11325	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NE421_RS11335	COG0583	DNA-binding transcription factor activity
NE421_RS11340	COG0024	Methionine aminopeptidase
NE421_RS11370	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NE421_RS11370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NE421_RS11375	COG1105	Belongs to the carbohydrate kinase PfkB family
NE421_RS11380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NE421_RS11380	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
NE421_RS11380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NE421_RS11395	COG3300	MHYT domain
NE421_RS11395	COG5001	Diguanylate cyclase
NE421_RS11415	COG0659	secondary active sulfate transmembrane transporter activity
NE421_RS11435	COG1113	amino acid transport
NE421_RS11445	COG1522	sequence-specific DNA binding
NE421_RS11470	COG1011	Hydrolase
NE421_RS11475	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NE421_RS11485	COG2137	regulation of response to DNA damage stimulus
NE421_RS11500	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NE421_RS11535	COG0575	Belongs to the CDS family
NE421_RS11540	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NE421_RS11565	COG3852	Histidine kinase
NE421_RS11570	COG2204	response regulator
NE421_RS11625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NE421_RS11630	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NE421_RS11650	COG0697	spore germination
NE421_RS11655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NE421_RS11670	COG0315	cyclic pyranopterin monophosphate synthase activity
NE421_RS11670	COG0521	Mo-molybdopterin cofactor biosynthetic process
NE421_RS11685	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NE421_RS11690	COG0243	molybdopterin cofactor binding
NE421_RS11700	COG0243	molybdopterin cofactor binding
NE421_RS11705	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NE421_RS11710	COG2146	nitrite reductase [NAD(P)H] activity
NE421_RS11710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NE421_RS11720	COG0745	RESPONSE REGULATOR receiver
NE421_RS11725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NE421_RS11725	COG1116	anion transmembrane transporter activity
NE421_RS11745	COG0511	ligase activity, forming carbon-carbon bonds
NE421_RS11760	COG2814	Major facilitator Superfamily
NE421_RS11780	COG0069	glutamate synthase activity
NE421_RS11800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NE421_RS11810	COG1454	alcohol dehydrogenase
NE421_RS11815	COG0824	Thioesterase
NE421_RS11830	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NE421_RS11855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NE421_RS11860	COG2030	dehydratase
NE421_RS11870	COG0183	Belongs to the thiolase family
NE421_RS11880	COG0583	DNA-binding transcription factor activity
NE421_RS11885	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NE421_RS11895	COG1522	sequence-specific DNA binding
NE421_RS11900	COG3135	benzoate transporter
NE421_RS11910	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NE421_RS11935	COG0589	response to stress
NE421_RS11940	COG0488	(ABC) transporter
NE421_RS11960	COG4773	Receptor
NE421_RS11990	COG0668	transmembrane transport
NE421_RS12030	COG0583	DNA-binding transcription factor activity
NE421_RS12035	COG2814	Major facilitator Superfamily
NE421_RS12040	COG2814	Major facilitator Superfamily
NE421_RS12045	COG0446	pyridine nucleotide-disulphide oxidoreductase
NE421_RS12050	COG3384	dioxygenase
NE421_RS12055	COG1028	Short-chain dehydrogenase reductase Sdr
NE421_RS12065	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
NE421_RS12070	COG4638	Rieske (2fe-2S)
NE421_RS12075	COG0583	DNA-binding transcription factor activity
NE421_RS12095	COG4569	acetaldehyde dehydrogenase (acetylating) activity
NE421_RS12100	COG3971	2-oxopent-4-enoate hydratase activity
NE421_RS12110	COG2271	Major facilitator Superfamily
NE421_RS12115	COG1234	tRNA 3'-trailer cleavage
NE421_RS12145	COG1538	Outer membrane efflux protein
NE421_RS12155	COG2885	chlorophyll binding
NE421_RS12155	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NE421_RS12175	COG2885	chlorophyll binding
NE421_RS12175	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NE421_RS12210	COG1605	Chorismate mutase
NE421_RS12230	COG0308	aminopeptidase N
NE421_RS12250	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
NE421_RS12260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NE421_RS12265	COG1454	alcohol dehydrogenase
NE421_RS12285	COG0531	amino acid
NE421_RS12290	COG4303	Ethanolamine ammonia lyase large subunit
NE421_RS12295	COG4302	ethanolamine ammonia-lyase activity
NE421_RS12300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NE421_RS12300	COG0519	Catalyzes the synthesis of GMP from XMP
NE421_RS12305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NE421_RS12330	COG0697	spore germination
NE421_RS12335	COG1923	regulation of RNA biosynthetic process
NE421_RS12345	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NE421_RS12350	COG0802	atpase or kinase
NE421_RS12370	COG1187	pseudouridine synthase activity
NE421_RS12385	COG0583	DNA-binding transcription factor activity
NE421_RS12505	COG2369	cell adhesion
NE421_RS12510	COG4383	Mu-like prophage protein gp29
NE421_RS12525	COG4373	Mu-like prophage FluMu protein gp28
NE421_RS12600	COG3267	Type II secretory pathway component ExeA
NE421_RS12600	COG3409	Peptidoglycan-binding domain 1 protein
NE421_RS12680	COG2814	Major facilitator Superfamily
NE421_RS12685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NE421_RS12710	COG0729	surface antigen
NE421_RS12730	COG0174	glutamine synthetase
NE421_RS12735	COG0745	RESPONSE REGULATOR receiver
NE421_RS12740	COG2205	protein histidine kinase activity
NE421_RS12750	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NE421_RS12755	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NE421_RS12775	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NE421_RS12780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NE421_RS12785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NE421_RS12790	COG1960	acyl-CoA dehydrogenase activity
NE421_RS12820	COG0583	DNA-binding transcription factor activity
NE421_RS12835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NE421_RS12845	COG3658	cytochrome
NE421_RS12850	COG1215	transferase activity, transferring glycosyl groups
NE421_RS12855	COG1649	PFAM Uncharacterised BCR, COG1649
NE421_RS12855	COG0726	polysaccharide deacetylase
NE421_RS12880	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NE421_RS12885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NE421_RS12895	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NE421_RS12920	COG0305	Participates in initiation and elongation during chromosome replication
NE421_RS12925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NE421_RS12935	COG1305	Transglutaminase-like
NE421_RS12945	COG2308	Evidence 4 Homologs of previously reported genes of
NE421_RS12975	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NE421_RS12980	COG0138	bifunctional purine biosynthesis protein purh
NE421_RS12985	COG0151	Belongs to the GarS family
NE421_RS12990	COG1464	Belongs to the NlpA lipoprotein family
NE421_RS12995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NE421_RS13000	COG2011	ABC-type metal ion transport system permease component
NE421_RS13005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NE421_RS13015	COG1301	dicarboxylic acid transport
NE421_RS13045	COG1794	racemase activity, acting on amino acids and derivatives
NE421_RS13065	COG0745	RESPONSE REGULATOR receiver
NE421_RS13070	COG0642	Histidine kinase
NE421_RS13075	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NE421_RS13085	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NE421_RS13125	COG2351	hydroxyisourate hydrolase activity
NE421_RS13135	COG3008	intermembrane lipid transfer
NE421_RS13135	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NE421_RS13140	COG2995	paraquat-inducible protein a
NE421_RS13165	COG0477	Major facilitator Superfamily
NE421_RS13215	COG2186	Transcriptional regulator
NE421_RS13225	COG0786	glutamate:sodium symporter activity
NE421_RS13230	COG3243	poly(R)-hydroxyalkanoic acid synthase
NE421_RS13255	COG3111	PFAM Bacterial OB fold (BOF) protein
NE421_RS13340	COG3210	domain, Protein
NE421_RS13340	COG3210	domain, Protein
NE421_RS13345	COG2831	hemolysin activation secretion protein
NE421_RS13370	COG0515	serine threonine protein kinase
NE421_RS13370	COG2815	serine threonine protein kinase
NE421_RS13400	COG1610	YqeY-like protein
NE421_RS13405	COG4783	chaperone-mediated protein folding
NE421_RS13430	COG1286	toxin biosynthetic process
NE421_RS13460	COG0778	Nitroreductase
NE421_RS13470	COG0513	Belongs to the DEAD box helicase family
NE421_RS13495	COG2363	Small membrane protein
NE421_RS13525	COG4650	regulator
NE421_RS13530	COG1234	tRNA 3'-trailer cleavage
NE421_RS13535	COG1690	Belongs to the RtcB family
NE421_RS13555	COG2195	Cleaves the N-terminal amino acid of tripeptides
NE421_RS13565	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NE421_RS13575	COG2819	hydrolase of the alpha beta superfamily
NE421_RS13580	COG1960	acyl-CoA dehydrogenase activity
NE421_RS13585	COG1301	dicarboxylic acid transport
NE421_RS13590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NE421_RS13595	COG3139	Protein of unknown function (DUF1315)
NE421_RS13600	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NE421_RS13605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NE421_RS13615	COG0494	nUDIX hydrolase
NE421_RS13625	COG0642	Histidine kinase
NE421_RS13640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NE421_RS13650	COG1720	tRNA m6t6A37 methyltransferase activity
NE421_RS13665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NE421_RS13670	COG0826	peptidase U32
NE421_RS13675	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NE421_RS13685	COG4598	ABC transporter
NE421_RS13690	COG4160	amino acid transport
NE421_RS13695	COG4215	(ABC) transporter
NE421_RS13710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NE421_RS13755	COG1131	(ABC) transporter
NE421_RS13760	COG0842	Transport permease protein
NE421_RS13775	COG0772	Belongs to the SEDS family
NE421_RS13780	COG2951	lytic endotransglycosylase activity
NE421_RS13805	COG2207	Transcriptional regulator
NE421_RS13820	COG0052	Belongs to the universal ribosomal protein uS2 family
NE421_RS13825	COG0024	Methionine aminopeptidase
NE421_RS13835	COG2223	nitrite transmembrane transporter activity
NE421_RS13845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NE421_RS13850	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NE421_RS13855	COG1960	acyl-CoA dehydrogenase activity
NE421_RS13870	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NE421_RS13875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NE421_RS13880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NE421_RS13900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NE421_RS13905	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NE421_RS13910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NE421_RS13945	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NE421_RS13955	COG0174	glutamine synthetase
NE421_RS13970	COG0512	Glutamine amidotransferase of anthranilate synthase
NE421_RS13975	COG0308	aminopeptidase N
NE421_RS13995	COG2840	Smr protein MutS2
NE421_RS14005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NE421_RS14015	COG0302	gtp cyclohydrolase
NE421_RS14035	COG3739	integral membrane protein
NE421_RS14050	COG1169	isochorismate synthase
NE421_RS14055	COG2977	Belongs to the P-Pant transferase superfamily
NE421_RS14060	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NE421_RS14065	COG1132	(ABC) transporter
NE421_RS14070	COG1132	(ABC) transporter
NE421_RS14085	COG1535	isochorismatase
NE421_RS14085	COG3433	isochorismatase activity
NE421_RS14090	COG1021	2,3-dihydroxybenzoate-AMP ligase
NE421_RS14095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NE421_RS14105	COG4774	siderophore transport
NE421_RS14110	COG4607	ABC-type enterochelin transport system periplasmic component
NE421_RS14115	COG4604	ABC transporter, ATP-binding protein
NE421_RS14120	COG4605	iron ion homeostasis
NE421_RS14125	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NE421_RS14130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NE421_RS14145	COG2964	Protein conserved in bacteria
NE421_RS14155	COG1741	Belongs to the pirin family
NE421_RS14170	COG1309	transcriptional regulator
NE421_RS14175	COG1309	transcriptional regulator
NE421_RS14185	COG4948	Mandelate Racemase Muconate Lactonizing
NE421_RS14220	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NE421_RS14220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NE421_RS14225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NE421_RS14235	COG1012	belongs to the aldehyde dehydrogenase family
NE421_RS14250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NE421_RS14255	COG0583	DNA-binding transcription factor activity
NE421_RS14265	COG2879	small protein
NE421_RS14270	COG1966	Carbon starvation protein
NE421_RS14290	COG4943	cyclic-guanylate-specific phosphodiesterase activity
NE421_RS14310	COG2211	Major facilitator Superfamily
NE421_RS14315	COG1067	ATP-dependent peptidase activity
NE421_RS14320	COG0583	DNA-binding transcription factor activity
NE421_RS14345	COG1686	Belongs to the peptidase S11 family
NE421_RS14350	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NE421_RS14385	COG0616	signal peptide processing
NE421_RS14390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NE421_RS14400	COG0573	inorganic phosphate transmembrane transporter activity
NE421_RS14405	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NE421_RS14410	COG1113	amino acid transport
NE421_RS14415	COG3961	Belongs to the TPP enzyme family
NE421_RS14420	COG1522	sequence-specific DNA binding
NE421_RS14430	COG0076	glutamate decarboxylase activity
NE421_RS14435	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NE421_RS14445	COG1309	transcriptional regulator
NE421_RS14460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NE421_RS14495	COG0352	thiamine-phosphate diphosphorylase activity
NE421_RS14520	COG1203	CRISPR-associated helicase, Cas3
NE421_RS14550	COG0612	Peptidase, M16
NE421_RS14560	COG1823	symporter activity
NE421_RS14565	COG0583	DNA-binding transcription factor activity
NE421_RS14570	COG0477	Major facilitator Superfamily
NE421_RS14590	COG1187	pseudouridine synthase activity
NE421_RS14605	COG1686	Belongs to the peptidase S11 family
NE421_RS14610	COG1252	NADH dehydrogenase
NE421_RS14620	COG0415	Belongs to the DNA photolyase family
NE421_RS14635	COG1215	transferase activity, transferring glycosyl groups
NE421_RS14665	COG2070	2-Nitropropane dioxygenase
NE421_RS14720	COG0556	nucleotide-excision repair
NE421_RS14740	COG0436	Aminotransferase
NE421_RS14770	COG4221	oxidoreductase activity
NE421_RS14780	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NE421_RS14785	COG1381	Involved in DNA repair and RecF pathway recombination
NE421_RS14795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NE421_RS14810	COG0681	Belongs to the peptidase S26 family
NE421_RS14820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NE421_RS14830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NE421_RS14850	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NE421_RS14855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NE421_RS14860	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NE421_RS14870	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NE421_RS14875	COG4208	sulfate ABC transporter
NE421_RS14880	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NE421_RS14890	COG4625	pathogenesis
NE421_RS14905	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NE421_RS14920	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NE421_RS14930	COG1051	belongs to the nudix hydrolase family
NE421_RS14930	COG1056	cytidyltransferase-related domain
NE421_RS14935	COG1024	Enoyl-CoA hydratase
NE421_RS14950	COG2814	Major facilitator Superfamily
NE421_RS14955	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NE421_RS14955	COG0047	phosphoribosylformylglycinamidine synthase activity
NE421_RS14975	COG1473	amidohydrolase
NE421_RS14980	COG0824	Thioesterase
NE421_RS15000	COG0823	Involved in the tonB-independent uptake of proteins
NE421_RS15020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NE421_RS15055	COG0628	permease
NE421_RS15065	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NE421_RS15070	COG0596	Alpha beta hydrolase
NE421_RS15075	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NE421_RS15075	COG0616	signal peptide processing
NE421_RS15085	COG0658	competence protein
NE421_RS15085	COG2333	competence protein COMEC
NE421_RS15090	COG1136	(ABC) transporter
NE421_RS15095	COG4591	ABC-type transport system involved in lipoprotein release permease component
NE421_RS15130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NE421_RS15150	COG0463	Glycosyl transferase, family 2
NE421_RS15180	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NE421_RS15185	COG1280	lysine exporter protein (LysE YggA)
NE421_RS15195	COG0019	diaminopimelate decarboxylase activity
NE421_RS15205	COG1113	amino acid transport
NE421_RS15220	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
NE421_RS15230	COG3339	Conserved Protein
NE421_RS15235	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NE421_RS15240	COG0243	molybdopterin cofactor binding
NE421_RS15245	COG1929	Belongs to the glycerate kinase type-1 family
NE421_RS15260	COG0778	Nitroreductase
NE421_RS15280	COG3811	Belongs to the UPF0386 family
NE421_RS15290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NE421_RS15300	COG0582	viral genome integration into host DNA
NE421_RS15315	COG0596	Alpha beta hydrolase
NE421_RS15320	COG0778	Nitroreductase
NE421_RS15325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NE421_RS15330	COG1335	isochorismatase
NE421_RS15335	COG0251	oxidation-reduction process
NE421_RS15340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NE421_RS15345	COG2233	PERMEase
NE421_RS15425	COG0069	glutamate synthase activity
NE421_RS15430	COG2218	PFAM glutamate synthase alpha subunit domain protein
NE421_RS15435	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NE421_RS15450	COG0004	ammonium transporteR
NE421_RS15460	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NE421_RS15460	COG0446	pyridine nucleotide-disulphide oxidoreductase
NE421_RS15475	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NE421_RS15490	COG0347	Belongs to the P(II) protein family
NE421_RS15495	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NE421_RS15505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NE421_RS15525	COG2197	response regulator
NE421_RS15530	COG3850	Histidine kinase
NE421_RS15535	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NE421_RS15540	COG0004	ammonium transporteR
NE421_RS15545	COG2076	Multidrug Resistance protein
NE421_RS15585	COG2851	Citrate transporter
NE421_RS15590	COG0583	DNA-binding transcription factor activity
NE421_RS15600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NE421_RS15620	COG0741	lytic transglycosylase activity
NE421_RS15640	COG0584	glycerophosphoryl diester phosphodiesterase
NE421_RS15645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NE421_RS15665	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NE421_RS15670	COG1597	lipid kinase activity
NE421_RS15685	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NE421_RS15690	COG0477	Major facilitator Superfamily
NE421_RS15740	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NE421_RS15745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NE421_RS15770	COG0505	Belongs to the CarA family
NE421_RS15790	COG0589	response to stress
NE421_RS15805	COG2843	Capsule synthesis protein
NE421_RS15825	COG2321	neutral zinc metallopeptidase
NE421_RS15830	COG2354	Protein conserved in bacteria
NE421_RS15850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NE421_RS15875	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NE421_RS15880	COG1053	succinate dehydrogenase
NE421_RS15885	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NE421_RS15890	COG2009	succinate dehydrogenase
NE421_RS15925	COG2921	Belongs to the UPF0250 family
NE421_RS15930	COG0321	lipoyl(octanoyl) transferase activity
NE421_RS15945	COG0531	amino acid
NE421_RS15955	COG1733	regulation of RNA biosynthetic process
NE421_RS15960	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NE421_RS15965	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NE421_RS15965	COG1648	precorrin-2 dehydrogenase activity
NE421_RS15980	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NE421_RS16010	COG0671	phosphoesterase, PA-phosphatase related
NE421_RS16015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NE421_RS16025	COG1538	Outer membrane efflux protein
NE421_RS16030	COG0393	Putative heavy-metal-binding
NE421_RS16035	COG0393	Putative heavy-metal-binding
NE421_RS16045	COG1028	Short-chain dehydrogenase reductase Sdr
NE421_RS16055	COG0525	valine-tRNA ligase activity
NE421_RS16075	COG0583	DNA-binding transcription factor activity
NE421_RS16080	COG0004	ammonium transporteR
NE421_RS16090	COG0642	Histidine kinase
NE421_RS16095	COG0745	RESPONSE REGULATOR receiver
NE421_RS16100	COG2194	sulfuric ester hydrolase activity
NE421_RS16120	COG1752	Esterase of the alpha-beta hydrolase superfamily
NE421_RS16135	COG2315	Protein conserved in bacteria
NE421_RS16140	COG0142	geranyltranstransferase activity
NE421_RS16145	COG2828	Protein conserved in bacteria
NE421_RS16150	COG1113	amino acid transport
NE421_RS16170	COG2207	Transcriptional regulator
NE421_RS16195	COG2249	NAD(P)H dehydrogenase (quinone) activity
NE421_RS16205	COG0560	Phosphoserine phosphatase
NE421_RS16215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NE421_RS16225	COG1530	ribonuclease E activity
NE421_RS16230	COG0424	maF-like protein
NE421_RS16235	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NE421_RS16240	COG1792	Involved in formation and maintenance of cell shape
NE421_RS16245	COG1077	Cell shape determining protein MreB Mrl
NE421_RS16250	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NE421_RS16260	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NE421_RS16290	COG3590	peptidase
NE421_RS16295	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
NE421_RS16300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NE421_RS16305	COG1752	Esterase of the alpha-beta hydrolase superfamily
NE421_RS16310	COG1115	amino acid carrier protein
NE421_RS16330	COG2814	Major facilitator Superfamily
NE421_RS16335	COG1289	transmembrane transporter activity
NE421_RS16345	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NE421_RS16385	COG1376	ErfK ybiS ycfS ynhG family protein
NE421_RS16390	COG2832	Protein of unknown function (DUF454)
NE421_RS16400	COG5510	response to toxic substance
NE421_RS16420	COG0840	transmembrane signaling receptor activity
NE421_RS16460	COG3422	double-strand break repair
NE421_RS16465	COG2824	Alkylphosphonate utilization operon protein PhnA
NE421_RS16470	COG3189	MarR family transcriptional regulator
NE421_RS16480	COG0354	folic acid binding
NE421_RS16485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NE421_RS16495	COG0679	Auxin Efflux Carrier
NE421_RS16500	COG1902	pentaerythritol trinitrate reductase activity
NE421_RS16505	COG4772	TonB-dependent receptor
NE421_RS16510	COG2094	Belongs to the DNA glycosylase MPG family
NE421_RS16535	COG1217	gtp-binding protein TYPA
NE421_RS16540	COG2233	PERMEase
NE421_RS16550	COG0833	amino acid
NE421_RS16555	COG1690	Belongs to the RtcB family
NE421_RS16565	COG2885	chlorophyll binding
NE421_RS16565	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NE421_RS16575	COG0183	Belongs to the thiolase family
NE421_RS16595	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NE421_RS16615	COG2207	Transcriptional regulator
NE421_RS16620	COG0183	Belongs to the thiolase family
NE421_RS16650	COG1272	protein, Hemolysin III
NE421_RS16655	COG0477	Major facilitator Superfamily
NE421_RS16670	COG0450	alkyl hydroperoxide reductase
NE421_RS16690	COG0285	dihydrofolate synthase activity
NE421_RS16740	COG2096	Adenosyltransferase
NE421_RS16760	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NE421_RS16765	COG0745	RESPONSE REGULATOR receiver
NE421_RS16770	COG2205	protein histidine kinase activity
NE421_RS16780	COG1960	acyl-CoA dehydrogenase activity
NE421_RS16785	COG1960	acyl-CoA dehydrogenase activity
NE421_RS16835	COG1215	transferase activity, transferring glycosyl groups
NE421_RS16850	COG1091	dTDP-4-dehydrorhamnose reductase activity
NE421_RS16870	COG0726	polysaccharide deacetylase
NE421_RS16885	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NE421_RS16890	COG2205	protein histidine kinase activity
NE421_RS16925	COG1862	Preprotein translocase
NE421_RS16935	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NE421_RS16940	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NE421_RS16950	COG3781	membrane
NE421_RS16955	COG0613	PHP domain protein
NE421_RS16965	COG2350	Protein conserved in bacteria
NE421_RS16995	COG1607	acyl-coa hydrolase
NE421_RS17055	COG2199	diguanylate cyclase activity
NE421_RS17065	COG1408	metallophosphoesterase
NE421_RS17070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NE421_RS17080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NE421_RS17100	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NE421_RS17105	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NE421_RS17120	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NE421_RS17130	COG2969	positive regulation of protein catabolic process
NE421_RS17150	COG1960	acyl-CoA dehydrogenase activity
NE421_RS17155	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NE421_RS17170	COG1309	transcriptional regulator
NE421_RS17175	COG1960	acyl-CoA dehydrogenase activity
NE421_RS17220	COG1183	phosphatidylcholine synthase activity
NE421_RS17225	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NE421_RS17255	COG1196	nuclear chromosome segregation
NE421_RS17255	COG0741	lytic transglycosylase activity
NE421_RS17255	COG0739	heme binding
NE421_RS17265	COG1702	phosphate starvation-inducible protein PhoH
NE421_RS17300	COG1295	ribonuclease BN
NE421_RS17305	COG0697	spore germination
NE421_RS17310	COG2169	Transcriptional regulator
NE421_RS17315	COG0179	Fumarylacetoacetate (FAA) hydrolase
NE421_RS17360	COG0557	exoribonuclease II activity
NE421_RS17365	COG0339	signal peptide processing
NE421_RS17370	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
NE421_RS17400	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NE421_RS17405	COG1960	acyl-CoA dehydrogenase activity
NE421_RS17565	COG0433	COG0433 Predicted ATPase
NE421_RS17575	COG1017	nitric oxide dioxygenase activity
NE421_RS17575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NE421_RS17580	COG1959	2 iron, 2 sulfur cluster binding
NE421_RS17595	COG1301	dicarboxylic acid transport
NE421_RS17600	COG1946	Acyl-CoA thioesterase
NE421_RS17620	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NE421_RS17625	COG1040	competence protein
NE421_RS17630	COG0494	nUDIX hydrolase
NE421_RS17640	COG0598	Magnesium transport protein CorA
NE421_RS17650	COG2854	intermembrane phospholipid transfer
NE421_RS17660	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NE421_RS17665	COG1127	ABC transporter
NE421_RS17675	COG0513	Belongs to the DEAD box helicase family
NE421_RS17695	COG0408	coproporphyrinogen oxidase activity
NE421_RS17710	COG1960	acyl-CoA dehydrogenase activity
NE421_RS17720	COG1983	PspC domain protein
NE421_RS17725	COG0517	IMP dehydrogenase activity
NE421_RS17760	COG1106	Psort location Cytoplasmic, score
NE421_RS17780	COG0583	DNA-binding transcription factor activity
NE421_RS17820	COG1012	belongs to the aldehyde dehydrogenase family
NE421_RS17830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NE421_RS17835	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NE421_RS17840	COG0833	amino acid
NE421_RS17870	COG1192	Involved in chromosome partitioning
NE421_RS17875	COG0628	permease
NE421_RS17885	COG1289	transmembrane transporter activity
NE421_RS17900	COG2249	NAD(P)H dehydrogenase (quinone) activity
NE421_RS17905	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NE421_RS17925	COG0277	FAD linked oxidase domain protein
NE421_RS17930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NE421_RS17955	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NE421_RS17960	COG5380	lipid catabolic process
NE421_RS17980	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NE421_RS18030	COG0194	GDP metabolic process
NE421_RS18045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NE421_RS18065	COG3307	-O-antigen
NE421_RS18080	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NE421_RS18085	COG1704	LemA family
NE421_RS18095	COG0493	'glutamate synthase
NE421_RS18100	COG0067	glutamate synthase
NE421_RS18100	COG0069	glutamate synthase activity
NE421_RS18100	COG0070	glutamate synthase
NE421_RS18150	COG2226	methyltransferase
NE421_RS18165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NE421_RS18170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NE421_RS18215	COG0833	amino acid
NE421_RS18300	COG0488	(ABC) transporter
NE421_RS18310	COG4221	oxidoreductase activity
NE421_RS18315	COG0659	secondary active sulfate transmembrane transporter activity
NE421_RS18340	COG0427	acetyl-CoA hydrolase
NE421_RS18370	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NE421_RS18400	COG2329	Antibiotic biosynthesis monooxygenase
NE421_RS18415	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NE421_RS18480	COG2249	NAD(P)H dehydrogenase (quinone) activity
NE421_RS18485	COG1733	regulation of RNA biosynthetic process
NE421_RS18520	COG0667	Aldo Keto reductase
NE421_RS18540	COG0583	DNA-binding transcription factor activity
NE421_RS18545	COG2814	Major facilitator Superfamily
NE421_RS18575	COG1335	isochorismatase
NE421_RS18585	COG1012	belongs to the aldehyde dehydrogenase family
NE421_RS18590	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NE421_RS18600	COG1113	amino acid transport
NE421_RS18610	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NE421_RS18625	COG2814	Major facilitator Superfamily
NE421_RS18635	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NE421_RS18635	COG0352	thiamine-phosphate diphosphorylase activity
NE421_RS18635	COG0351	phosphomethylpyrimidine kinase
NE421_RS18655	COG1309	transcriptional regulator
NE421_RS18660	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NE421_RS18680	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NE421_RS18690	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NE421_RS18695	COG3162	membrane
NE421_RS18700	COG0784	Response regulator, receiver
NE421_RS18700	COG2198	Histidine kinase
NE421_RS18700	COG2205	protein histidine kinase activity
NE421_RS18725	COG1522	sequence-specific DNA binding
NE421_RS18730	COG1335	isochorismatase
NE421_RS18735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NE421_RS18745	COG0668	transmembrane transport
NE421_RS18750	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NE421_RS18755	COG1519	Transferase
NE421_RS18760	COG1902	pentaerythritol trinitrate reductase activity
NE421_RS18780	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NE421_RS18805	COG0426	domain, Protein
NE421_RS18805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NE421_RS18810	COG4774	siderophore transport
NE421_RS18815	COG2119	membrane
NE421_RS18825	COG0508	dehydrogenase complex catalyzes the overall conversion of
NE421_RS18835	COG4942	peptidase
NE421_RS18850	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NE421_RS18860	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NE421_RS18880	COG0189	ligase activity
NE421_RS18905	COG0708	Exodeoxyribonuclease III
NE421_RS18910	COG1393	Belongs to the ArsC family
NE421_RS18925	COG3706	GGDEF domain
NE421_RS18960	COG2351	hydroxyisourate hydrolase activity
NE421_RS18965	COG2233	PERMEase
NE421_RS18975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NE421_RS18985	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
NE421_RS18990	COG1028	Short-chain dehydrogenase reductase Sdr
NE421_RS19000	COG3150	esterase
NE421_RS19045	COG5632	N-Acetylmuramoyl-L-alanine amidase
NE421_RS19045	COG3409	Peptidoglycan-binding domain 1 protein
NE421_RS19045	COG1388	LysM domain
NE421_RS19060	COG2918	glutathione biosynthetic process
NE421_RS19075	COG2733	membrane
NE421_RS19080	COG0436	Aminotransferase
NE421_RS19085	COG0534	Mate efflux family protein
NE421_RS19170	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NE421_RS19175	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NE421_RS19185	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NE421_RS19200	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NE421_RS19215	COG0010	Belongs to the arginase family
NE421_RS19245	COG2188	Transcriptional regulator
NE421_RS19255	COG0523	cobalamin synthesis protein
NE421_RS19265	COG1113	amino acid transport
NE421_RS19275	COG0625	glutathione transferase activity
NE421_RS19295	COG1683	Conserved Protein
NE421_RS19300	COG0534	Mate efflux family protein
NE421_RS19305	COG0385	Bile acid
NE421_RS19310	COG1335	isochorismatase
NE421_RS19315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NE421_RS19335	COG2116	formate transmembrane transporter activity
NE421_RS19340	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NE421_RS19345	COG2133	pyrroloquinoline quinone binding
NE421_RS19350	COG2983	Belongs to the UPF0260 family
NE421_RS19370	COG1194	a g-specific adenine glycosylase
NE421_RS19385	COG2818	Glycosylase
NE421_RS19390	COG1064	alcohol dehydrogenase
NE421_RS19395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NE421_RS19410	COG0583	DNA-binding transcription factor activity
NE421_RS19415	COG0656	L-ascorbic acid biosynthetic process
NE421_RS19420	COG2814	Major facilitator Superfamily
NE421_RS19455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NE421_RS19470	COG2233	PERMEase
NE421_RS19475	COG0583	DNA-binding transcription factor activity
NE421_RS19510	COG0733	neurotransmitter:sodium symporter activity
NE421_RS19550	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NE421_RS19555	COG0657	acetylesterase activity
NE421_RS19575	COG0583	DNA-binding transcription factor activity
NE421_RS19605	COG2951	lytic endotransglycosylase activity
NE421_RS19610	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NE421_RS19625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NE421_RS19635	COG0671	phosphoesterase, PA-phosphatase related
NE421_RS19640	COG0861	Integral membrane protein TerC family
NE421_RS19650	COG0754	glutathionylspermidine amidase activity
NE421_RS19660	COG0402	S-adenosylhomocysteine deaminase activity
NE421_RS19675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NE421_RS19680	COG1230	cation diffusion facilitator family transporter
NE421_RS19695	COG0706	membrane insertase activity
NE421_RS19805	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NE421_RS19825	COG2369	cell adhesion
NE421_RS19830	COG0582	viral genome integration into host DNA
NE421_RS19835	COG0789	Transcriptional regulator
NE421_RS19845	COG1230	cation diffusion facilitator family transporter
NE421_RS19875	COG0789	Transcriptional regulator
NE421_RS19905	COG2207	Transcriptional regulator
NE421_RS19910	COG0633	Ferredoxin
NE421_RS19940	COG1309	transcriptional regulator
NE421_RS19985	COG1373	ATPase (AAA superfamily
NE421_RS20125	COG2801	Transposase and inactivated derivatives
NE421_RS20130	COG3173	Aminoglycoside phosphotransferase
NE421_RS20135	COG0488	(ABC) transporter
NE421_RS20155	COG3328	transposase activity
NE421_RS20160	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NE421_RS20165	COG3657	addiction module killer protein
NE421_RS20195	COG2826	transposase and inactivated derivatives, IS30 family
NE421_RS20205	COG2826	transposase and inactivated derivatives, IS30 family
NE421_RS20240	COG2076	Multidrug Resistance protein
NE421_RS20315	COG2184	nucleotidyltransferase activity
NE421_RS20340	COG2826	transposase and inactivated derivatives, IS30 family
NE421_RS20365	COG1324	tolerance protein
NE421_RS20395	COG2826	transposase and inactivated derivatives, IS30 family
NE421_RS20415	COG1475	DNA binding
NE421_RS20420	COG1192	Involved in chromosome partitioning
NE421_RS20435	COG0789	Transcriptional regulator