locus-tag class description H0S62_RS00035 ENOG4108D32 Methyltransferase H0S62_RS00060 ENOG4105C26 Dehydrogenase H0S62_RS00065 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) H0S62_RS00070 ENOG4105EVZ LysR family transcriptional regulator H0S62_RS00095 ENOG4105D9P serine threonine protein kinase H0S62_RS00125 ENOG4105KTH gatB Yqey H0S62_RS00130 ENOG4105ERG peptidase m48, ste24p H0S62_RS00135 ENOG4105C5I Dehydrogenase H0S62_RS00150 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase H0S62_RS00270 ENOG41069NU Nitroreductase H0S62_RS00280 ENOG4105C1J atp-dependent rna helicase H0S62_RS00285 ENOG4105VEQ Cold shock protein H0S62_RS00295 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H0S62_RS00300 ENOG4105M08 Membrane H0S62_RS00350 ENOG4105CIN aminoacyl-histidine dipeptidase H0S62_RS00360 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase H0S62_RS00365 ENOG4105CQC Prephenate dehydratase H0S62_RS00375 ENOG4105C1G acyl-Coa dehydrogenase H0S62_RS00380 ENOG4105CK2 sodium dicarboxylate symporter H0S62_RS00385 ENOG4107QYG anthranilate phosphoribosyltransferase H0S62_RS00390 ENOG4105VUT cytoplasmic protein H0S62_RS00395 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) H0S62_RS00400 ENOG4105BZ4 penicillin-binding protein H0S62_RS00410 ENOG4105M6F mutator MutT protein H0S62_RS00420 ENOG4105DHQ Histidine kinase H0S62_RS00425 ENOG4105XJC Two component transcriptional regulator (Winged helix family H0S62_RS00430 ENOG4108YDI single-species biofilm formation on inanimate substrate H0S62_RS00435 ENOG4107QHF type ii secretion system protein e H0S62_RS00445 ENOG4108R96 Methyltransferase, YaeB family H0S62_RS00450 ENOG4105DP0 ferredoxin-NADP reductase H0S62_RS00455 ENOG4105JAB phenazine biosynthesis protein, phzf family H0S62_RS00460 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H0S62_RS00465 ENOG4105CFP Peptidase U32 H0S62_RS00470 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding H0S62_RS00480 ENOG4108JEH abc transporter atp-binding protein H0S62_RS00485 ENOG4106YG3 ABC transporter H0S62_RS00490 ENOG4105DSP amino acid AbC transporter H0S62_RS00495 ENOG4105E89 ABC transporter H0S62_RS00505 ENOG4105ENT Efflux transporter rnd family, mfp subunit H0S62_RS00515 ENOG4105ENJ RND efflux system, outer membrane lipoprotein H0S62_RS00550 ENOG4105DA5 (ABC) transporter H0S62_RS00555 ENOG4105E3A (ABC) transporter H0S62_RS00570 ENOG4105CNI cell division protein FtsW H0S62_RS00575 ENOG4105CVE Lytic murein transglycosylase H0S62_RS00615 ENOG4105CE9 30S ribosomal protein S2 H0S62_RS00620 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) H0S62_RS00630 ENOG4107RNU major facilitator superfamily MFS_1 H0S62_RS00640 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) H0S62_RS00645 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) H0S62_RS00650 ENOG4107QPN acyl-Coa dehydrogenase H0S62_RS00665 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) H0S62_RS00670 ENOG4105SYT Methylenetetrahydrofolate reductase H0S62_RS00675 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) H0S62_RS00680 ENOG4105BZU Histidine kinase H0S62_RS00685 ENOG4105C6K Malic enzyme H0S62_RS00695 ENOG4105C0H protease H0S62_RS00700 ENOG4107QNR UPF0135 protein H0S62_RS00705 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H0S62_RS00740 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) H0S62_RS00755 ENOG4105DUX Transporter H0S62_RS00765 ENOG4105DDQ anthranilate synthase H0S62_RS00770 ENOG4105CD8 aminopeptidase N H0S62_RS00810 ENOG4105EUJ GTP cyclohydrolase i H0S62_RS00840 ENOG4105NX3 Membrane H0S62_RS00870 ENOG4108JJ7 ABC transporter H0S62_RS00890 ENOG4105WQI isochorismatase H0S62_RS00895 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase H0S62_RS00900 ENOG4105C0W non-ribosomal peptide synthetase H0S62_RS00945 ENOG4105WWK YheO domain protein H0S62_RS00955 ENOG4105C2I pirin domain protein H0S62_RS00970 ENOG4108HWW ABC transporter H0S62_RS00985 ENOG4105VCD cytoplasmic protein H0S62_RS00990 ENOG4105D22 carbon starvation protein H0S62_RS01000 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein H0S62_RS01010 ENOG41066DG (EAL) domain protein H0S62_RS01020 ENOG4105DHU Bile acid H0S62_RS01035 ENOG4105DAN ATP-dependent protease H0S62_RS01040 ENOG4105EJC lysr family transcriptional regulator H0S62_RS01045 ENOG4108K5P (LipO)protein H0S62_RS01065 ENOG4105DZ1 carboxypeptidase H0S62_RS01070 ENOG4108Z0R Transferase H0S62_RS01090 ENOG4107QTF adenylosuccinate lyase H0S62_RS01105 ENOG4105ERU peptidase H0S62_RS01110 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) H0S62_RS01120 ENOG4105C8U phosphate abc transporter H0S62_RS01125 ENOG4105CVA phosphate H0S62_RS01130 ENOG4105C85 amino acid H0S62_RS01135 ENOG4107RA9 decarboxylase H0S62_RS01140 ENOG4105F7P transcriptional regulator AsnC family H0S62_RS01150 ENOG4105DY8 decarboxylase H0S62_RS01155 ENOG4108JPW Aminotransferase H0S62_RS01180 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) H0S62_RS01195 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) H0S62_RS01200 ENOG4105D3G Pseudouridine synthase H0S62_RS01215 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) H0S62_RS01245 ENOG4105JAB phenazine biosynthesis protein, phzf family H0S62_RS01250 ENOG4108ETY sodium dicarboxylate symporter H0S62_RS01255 ENOG4105EGI Transcriptional regulator H0S62_RS01260 ENOG4105CBP Major Facilitator H0S62_RS01285 ENOG4108R99 pseudouridine synthase H0S62_RS01290 ENOG4105E9K Isocitrate dehydrogenase H0S62_RS01300 ENOG4105DZ1 carboxypeptidase H0S62_RS01305 ENOG4105CEP NADH dehydrogenase H0S62_RS01310 ENOG4108YZY peptidylprolyl cis-trans isomerase H0S62_RS01315 ENOG4105CVP deoxyribo-dipyrimidine photolyase H0S62_RS01335 ENOG4107R8N Glycosyl transferase, family 2 H0S62_RS01365 ENOG4105EA8 2-Nitropropane dioxygenase H0S62_RS01370 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) H0S62_RS01375 ENOG4107QS8 (LipO)protein H0S62_RS01410 ENOG4105DTR rard protein H0S62_RS01420 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) H0S62_RS01430 ENOG4105BZU Histidine kinase H0S62_RS01470 ENOG4105EMU Dehydrogenase H0S62_RS01480 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase H0S62_RS01485 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) H0S62_RS01490 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) H0S62_RS01500 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) H0S62_RS01515 ENOG4105C3F Signal peptidase i H0S62_RS01530 ENOG4105C0H protease H0S62_RS01535 ENOG4108IYU L-aspartate oxidase H0S62_RS01550 ENOG4105HHA aminodeoxychorismate lyase H0S62_RS01555 ENOG4105YAZ 4-amino-4-deoxychorismate lyase H0S62_RS01560 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein H0S62_RS01570 ENOG4108I5D sulfate abc transporter H0S62_RS01580 ENOG4108IJ6 ABC transporter H0S62_RS01585 ENOG4107R11 Transcriptional regulator H0S62_RS01600 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) H0S62_RS01605 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) H0S62_RS01620 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen H0S62_RS01635 ENOG4108UKI Enoyl-CoA hydratase H0S62_RS01645 ENOG4105C2C drug resistance transporter, Bcr CflA H0S62_RS01650 ENOG4108ETH Formylglycinamide ribotide synthetase H0S62_RS01670 ENOG4105CH2 amidohydrolase H0S62_RS01675 ENOG4107YD3 Thioesterase H0S62_RS01680 ENOG4105E02 MotA TolQ exbB proton channel H0S62_RS01685 ENOG4105M8F Biopolymer transport protein exbD tolR H0S62_RS01695 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) H0S62_RS01700 ENOG4105KCK Peptidoglycan-associated lipoprotein H0S62_RS01760 ENOG4105C02 permease H0S62_RS01770 ENOG4108V3E phosphoribosylglycinamide formyltransferase H0S62_RS01775 ENOG4107R6F Alpha Beta Hydrolase Fold protein H0S62_RS01780 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) H0S62_RS01790 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 H0S62_RS01795 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) H0S62_RS01800 ENOG4105D60 lipoprotein releasing system transmembrane protein H0S62_RS01835 ENOG4107KET secretion protein, HlyD family H0S62_RS01870 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H0S62_RS01875 ENOG4105C10 Electron transfer flavoprotein H0S62_RS01880 ENOG4105BZJ Electron transfer flavoprotein H0S62_RS01885 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H0S62_RS01890 ENOG4105N14 lysine exporter protein LysE YggA H0S62_RS01900 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) H0S62_RS01910 ENOG4105C85 amino acid H0S62_RS01915 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) H0S62_RS01925 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) H0S62_RS01940 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) H0S62_RS01945 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit H0S62_RS01950 ENOG4105BZW Glycerate kinase H0S62_RS01990 ENOG4105CEY Amp-dependent synthetase and ligase H0S62_RS02005 ENOG4108RRZ Transcription elongation factor GreB H0S62_RS02025 ENOG4105E4C Lytic transglycosylase catalytic H0S62_RS02040 ENOG4105BZS acriflavin resistance protein H0S62_RS02045 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase H0S62_RS02055 ENOG41080IJ Diacylglycerol kinase H0S62_RS02070 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) H0S62_RS02085 ENOG4105C6V Glycerol-3-phosphate dehydrogenase H0S62_RS02090 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) H0S62_RS02095 ENOG4105CSH Transporter H0S62_RS02165 ENOG4105EEI dihydropteroate synthase H0S62_RS02170 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) H0S62_RS02180 ENOG4105HBR Rna-binding protein H0S62_RS02195 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain H0S62_RS02200 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain H0S62_RS02210 ENOG4108IG5 Transcriptional regulator H0S62_RS02215 ENOG4108UQ8 endoribonuclease L-psp H0S62_RS02225 ENOG41080TK Universal stress protein H0S62_RS02240 ENOG4105PNM synthesis protein H0S62_RS02250 ENOG4105F9F transposase H0S62_RS02265 ENOG4105EEQ Na H antiporter H0S62_RS02270 ENOG4105CGZ zinc metallopeptidase H0S62_RS02275 ENOG4105CKW Inner membrane protein yedI H0S62_RS02285 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha H0S62_RS02295 ENOG4107QN2 dihydrolipoyl dehydrogenase H0S62_RS02300 ENOG4105C7S Dehydrogenase H0S62_RS02305 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 H0S62_RS02320 ENOG4105E33 succinate dehydrogenase H0S62_RS02330 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein H0S62_RS02335 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit H0S62_RS02365 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H0S62_RS02370 ENOG41084BA UPF0250 protein H0S62_RS02375 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) H0S62_RS02390 ENOG4105CUB amino acid H0S62_RS02405 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) H0S62_RS02410 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) H0S62_RS02425 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) H0S62_RS02455 ENOG410841Q phosphoesterase PA-phosphatase related protein H0S62_RS02460 ENOG4105C1P efflux transporter, rnd family, mfp subunit H0S62_RS02465 ENOG4105BZS acriflavin resistance protein H0S62_RS02470 ENOG4105ENJ RND efflux system, outer membrane lipoprotein H0S62_RS02475 ENOG4105K8R UPF0145 protein H0S62_RS02480 ENOG4105K8R UPF0145 protein H0S62_RS02500 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) H0S62_RS02530 ENOG4108M0I Transcriptional regulator H0S62_RS02545 ENOG4105DHQ Histidine kinase H0S62_RS02550 ENOG4105XJC Two component transcriptional regulator (Winged helix family H0S62_RS02555 ENOG4105DIJ Phosphoethanolamine transferase H0S62_RS02575 ENOG4105D78 K07001 NTE family protein H0S62_RS02590 ENOG4105MSB protein, conserved in bacteria H0S62_RS02595 ENOG4105CTB Polyprenyl synthetase H0S62_RS02600 ENOG4105C7F AcnD-accessory protein PrpF H0S62_RS02605 ENOG4105C85 amino acid H0S62_RS02625 ENOG4105CF7 AraC family transcriptional regulator H0S62_RS02650 ENOG4108X0B nad(p)h dehydrogenase (quinone) H0S62_RS02660 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein H0S62_RS02670 ENOG4105D8T Acyltransferase H0S62_RS02680 ENOG4105C03 ribonuclease H0S62_RS02685 ENOG4108Z03 MAF-like protein H0S62_RS02690 ENOG4105VQ7 Rod shape-determining protein MreD H0S62_RS02695 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) H0S62_RS02705 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) H0S62_RS02715 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) H0S62_RS02750 ENOG4105C9K Endothelin-converting enzyme 1 H0S62_RS02770 ENOG4105D5G Transposase H0S62_RS02780 ENOG4105C7B Threonine dehydratase H0S62_RS02785 ENOG4105D78 K07001 NTE family protein H0S62_RS02790 ENOG4105BZG amino acid carrier protein H0S62_RS02810 ENOG4105C2C drug resistance transporter, Bcr CflA H0S62_RS02815 ENOG4105EM2 membrane H0S62_RS02865 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein H0S62_RS02870 ENOG4105WD1 Membrane H0S62_RS02880 ENOG4107PEH Entericidin EcnA/B family H0S62_RS02925 ENOG4105C8Q Methyl-accepting chemotaxis H0S62_RS02930 ENOG4108ZGA chew protein H0S62_RS02935 ENOG4105M3Z response regulator H0S62_RS02940 ENOG4108UNF response regulator H0S62_RS02965 ENOG4105KWI UPF0339 protein H0S62_RS02970 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA H0S62_RS02975 ENOG4105K78 MarR family Transcriptional regulator H0S62_RS02980 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) H0S62_RS02985 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) H0S62_RS02990 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) H0S62_RS02995 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) H0S62_RS03000 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) H0S62_RS03005 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) H0S62_RS03010 ENOG4105C2W permease H0S62_RS03025 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) H0S62_RS03030 ENOG4105T95 Thiol disulfide interChange protein H0S62_RS03045 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H0S62_RS03050 ENOG4105CHB tonB-dependent Receptor H0S62_RS03055 ENOG4108VX5 3-methyladenine DNA glycosylase H0S62_RS03065 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) H0S62_RS03080 ENOG4105CI3 gtp-binding protein typa H0S62_RS03085 ENOG4105C2W permease H0S62_RS03095 ENOG4108IQI permease H0S62_RS03100 ENOG4105E0Y RtcB Protein H0S62_RS03110 ENOG4108WHA ompa motb domain protein H0S62_RS03120 ENOG4105CHU acetyl-coa acetyltransferase H0S62_RS03140 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) H0S62_RS03145 ENOG4105DZG Dehydrogenase H0S62_RS03150 ENOG4105TW1 Carbohydrate-selective porin OprB H0S62_RS03160 ENOG4108R6W Transcriptional regulator, ARAC family H0S62_RS03165 ENOG4105CHU acetyl-coa acetyltransferase H0S62_RS03185 ENOG41082BV acetyltransferase H0S62_RS03195 ENOG4108UT2 hemolysin iii H0S62_RS03200 ENOG4105CSH Transporter H0S62_RS03215 ENOG4105D3R alkyl hydroperoxide reductase H0S62_RS03235 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase H0S62_RS03280 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) H0S62_RS03285 ENOG4108WBT adenosyltransferase H0S62_RS03305 ENOG4105CNG UPF0061 protein H0S62_RS03310 ENOG4105E3W Two component transcriptional regulator (Winged helix family H0S62_RS03315 ENOG4105EB3 Histidine kinase H0S62_RS03325 ENOG4105CSU acyl-Coa dehydrogenase H0S62_RS03330 ENOG4105CSU acyl-Coa dehydrogenase H0S62_RS03335 ENOG4108VY7 phosphate-starvation-inducible protein PsiE H0S62_RS03355 ENOG4105UGU tonB-dependent Receptor H0S62_RS03385 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase H0S62_RS03395 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase H0S62_RS03400 ENOG4105C1B dTDP-glucose 4-6-dehydratase H0S62_RS03410 ENOG4107TYR Glycosyl Transferase H0S62_RS03415 ENOG4107BJW polysaccharide deacetylase H0S62_RS03425 ENOG4105CM2 brancheD-chain amino acid aminotransferase H0S62_RS03430 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) H0S62_RS03435 ENOG4105BZU Histidine kinase H0S62_RS03445 ENOG4106050 phage regulatory protein, rha family H0S62_RS03460 ENOG4105ED4 portal protein H0S62_RS03505 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase H0S62_RS03630 ENOG4106050 phage regulatory protein, rha family H0S62_RS03710 ENOG4105VIE preprotein translocase, subunit YajC H0S62_RS03715 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) H0S62_RS03720 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) H0S62_RS03730 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase H0S62_RS03740 ENOG4105FFC UPF0187 protein H0S62_RS03745 ENOG4105DB7 PHP domain protein H0S62_RS03755 ENOG4105K9H YciI-like protein H0S62_RS03785 ENOG4105NAU thioesterase Superfamily protein H0S62_RS03795 ENOG4107U2T alpha beta H0S62_RS03820 ENOG4107QN2 dihydrolipoyl dehydrogenase H0S62_RS03865 ENOG4105UYK outer membrane protein a H0S62_RS03875 ENOG4107RZC phospholipase d H0S62_RS03885 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) H0S62_RS03905 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) H0S62_RS03910 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) H0S62_RS03915 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) H0S62_RS03925 ENOG4108UJD 30S ribosomal protein S9 H0S62_RS03930 ENOG4107MKT Stringent starvation protein a H0S62_RS03935 ENOG4105KB2 stringent starvation protein b H0S62_RS03955 ENOG4105C1G acyl-Coa dehydrogenase H0S62_RS03960 ENOG4107QX3 carboxylase H0S62_RS03975 ENOG4108RZE Tetr family transcriptional regulator H0S62_RS03985 ENOG4105C1G acyl-Coa dehydrogenase H0S62_RS04040 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase H0S62_RS04045 ENOG4105D6S protein involved in catabolism of external DNA H0S62_RS04075 ENOG4105E4C Lytic transglycosylase catalytic H0S62_RS04085 ENOG4105C9A Phoh family H0S62_RS04125 ENOG4105CS1 NAD(P)H quinone oxidoreductase H0S62_RS04130 ENOG4107S2Z UPF0761 membrane protein H0S62_RS04140 ENOG4108K2B transcriptional regulator H0S62_RS04145 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase H0S62_RS04200 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) H0S62_RS04205 ENOG4105DGW oligopeptidase A H0S62_RS04210 ENOG4105VKU nucleicacid-binding protein H0S62_RS04235 ENOG4105C1G acyl-Coa dehydrogenase H0S62_RS04275 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) H0S62_RS04385 ENOG41089BK Glutamine amido-transferase H0S62_RS04395 ENOG4105D7A ATP-binding protein H0S62_RS04410 ENOG4105KPV Transcriptional regulator H0S62_RS04425 ENOG4105CK2 sodium dicarboxylate symporter H0S62_RS04430 ENOG4105C29 acyl-CoA thioesterase H0S62_RS04450 ENOG4105CB5 ATP-dependent DNA helicase recG H0S62_RS04465 ENOG4108URH decarboxylase H0S62_RS04470 ENOG4105D7N magnesium and cobalt transport protein CorA H0S62_RS04480 ENOG4105E3I toluene tolerance H0S62_RS04490 ENOG4105CY3 ABC transporter, permease H0S62_RS04495 ENOG4105DHJ ABC, transporter H0S62_RS04505 ENOG4105C1J atp-dependent rna helicase H0S62_RS04510 ENOG4105ECY inositol monophosphatase H0S62_RS04525 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) H0S62_RS04540 ENOG4105CSU acyl-Coa dehydrogenase H0S62_RS04550 ENOG41067S9 phage shock protein C, PspC H0S62_RS04555 ENOG4105W87 Cbs domain H0S62_RS04645 ENOG4105C26 Dehydrogenase H0S62_RS04655 ENOG4105C8Y Acetylornithine aminotransferase H0S62_RS04660 ENOG4105D82 Glutamate dehydrogenase H0S62_RS04665 ENOG4108IQI permease H0S62_RS04695 ENOG4107SKI cobyrinic Acid a,c-diamide synthase H0S62_RS04700 ENOG4105IPI Membrane H0S62_RS04705 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H0S62_RS04715 ENOG4105EM2 membrane H0S62_RS04720 ENOG4107QF7 multi-drug H0S62_RS04730 ENOG4105NF4 modulator of drug activity H0S62_RS04735 ENOG4105VRH Antibiotic biosynthesis monooxygenase H0S62_RS04745 ENOG4105CQB FAD linked oxidase domain protein H0S62_RS04750 ENOG4108JQ1 Dehydrogenase H0S62_RS04775 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) H0S62_RS04780 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) H0S62_RS04785 ENOG4107IFA Lipase (EC 3.1.1.3) H0S62_RS04800 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) H0S62_RS04850 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) H0S62_RS04865 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) H0S62_RS04870 ENOG4105KME endoribonuclease L-psp H0S62_RS04880 ENOG4108UQY Iron-storage protein H0S62_RS04885 ENOG4108YSG O-Antigen polymerase H0S62_RS04900 ENOG4105HA9 of methanol dehydrogenase type H0S62_RS04905 ENOG4108V0P LemA family H0S62_RS04915 ENOG4105BZ8 glutamate synthase H0S62_RS04920 ENOG4105CBC glutamate synthase H0S62_RS04940 ENOG4105E4G Type IV pilus H0S62_RS04965 ENOG4108JQC penicillin-binding protein 1A H0S62_RS04970 ENOG4105DHI Methyltransferase H0S62_RS04985 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) H0S62_RS04990 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) H0S62_RS04995 ENOG4105CJN penicillin-binding protein H0S62_RS05010 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein H0S62_RS05035 ENOG4108IQI permease H0S62_RS05135 ENOG4105C5H ABC transporter H0S62_RS05145 ENOG4105PDP Short chain dehydrogenase H0S62_RS05150 ENOG4105CHH sulfate transporter H0S62_RS05165 ENOG4105E0F Histidine kinase H0S62_RS05175 ENOG4105CYC Transferase H0S62_RS05180 ENOG4108R6G acetyltransferase H0S62_RS05205 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) H0S62_RS05245 ENOG4105CUV Homoserine Kinase H0S62_RS05315 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein H0S62_RS05325 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) H0S62_RS05330 ENOG4105CPC Aldo Keto reductase H0S62_RS05350 ENOG4106NZI LysR family Transcriptional regulator H0S62_RS05355 ENOG4105D94 Major Facilitator Superfamily H0S62_RS05380 ENOG4105EUB pirin domain protein H0S62_RS05385 ENOG4105CHJ isochorismatase hydrolase H0S62_RS05395 ENOG4105C26 Dehydrogenase H0S62_RS05400 ENOG4108JPW Aminotransferase H0S62_RS05410 ENOG4105C85 amino acid H0S62_RS05420 ENOG4108UMN azlc family H0S62_RS05430 ENOG4108UUM single-stranded DNA-binding protein H0S62_RS05435 ENOG4107RDB Major Facilitator H0S62_RS05450 ENOG4105DWF phosphomethylpyrimidine kinase H0S62_RS05455 ENOG4105RA2 Membrane H0S62_RS05465 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein H0S62_RS05470 ENOG4108WUH Transcriptional regulator, TetR family H0S62_RS05475 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) H0S62_RS05480 ENOG4105BZU Histidine kinase H0S62_RS05490 ENOG4105C94 Transporter H0S62_RS05500 ENOG4107QN1 sodium solute H0S62_RS05505 ENOG41062QD Membrane H0S62_RS05510 ENOG4105BZU Histidine kinase H0S62_RS05525 ENOG4108UZX fmn reductase H0S62_RS05530 ENOG4105FBW Monooxygenase H0S62_RS05540 ENOG4108W2Y isochorismatase H0S62_RS05545 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H0S62_RS05555 ENOG4105D64 Mechanosensitive ion channel H0S62_RS05565 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase H0S62_RS05570 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H0S62_RS05590 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) H0S62_RS05605 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) H0S62_RS05620 ENOG4105E0K tonB-dependent siderophore receptor H0S62_RS05635 ENOG4107QSN dihydrolipoamide acetyltransferase H0S62_RS05640 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) H0S62_RS05645 ENOG41063SB peptidase H0S62_RS05660 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) H0S62_RS05665 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) H0S62_RS05670 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) H0S62_RS05690 ENOG4105D7Z glutathione synthase H0S62_RS05715 ENOG4105CGK Exodeoxyribonuclease III H0S62_RS05720 ENOG4105KUZ arsenate reductase H0S62_RS05735 ENOG4105BZU Histidine kinase H0S62_RS05740 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) H0S62_RS05770 ENOG41084YZ Hydrolase H0S62_RS05785 ENOG41061H0 Monooxygenase H0S62_RS05795 ENOG4108Z2U ureidoglycolate hydrolase H0S62_RS05800 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H0S62_RS05805 ENOG4105IPS esterase H0S62_RS05825 ENOG4105D9M gamma-glutamylcysteine synthetase H0S62_RS05840 ENOG4106BRA Membrane H0S62_RS05845 ENOG4105CHM Aminotransferase H0S62_RS05850 ENOG4107QJQ Mate efflux family protein H0S62_RS05865 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H0S62_RS05870 ENOG4105BZU Histidine kinase H0S62_RS05885 ENOG4105KHC sulfurtransferase H0S62_RS05930 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) H0S62_RS05945 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) H0S62_RS05950 ENOG4108ZAI phosphatidylglycerophosphatase a H0S62_RS05960 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) H0S62_RS06015 ENOG41088SP formiminoglutamate hydrolase H0S62_RS06025 ENOG4105C85 amino acid H0S62_RS06040 ENOG41090B9 response to stress H0S62_RS06045 ENOG4105CZE histidine utilization repressor H0S62_RS06055 ENOG4105CKI cobalamin synthesis protein H0S62_RS06065 ENOG4105C85 amino acid H0S62_RS06075 ENOG4108RXX maleylacetoacetate isomerase H0S62_RS06095 ENOG4105EWC Purine nucleoside phosphorylase H0S62_RS06100 ENOG4107QI1 Mate efflux family protein H0S62_RS06105 ENOG4105C09 Bile acid H0S62_RS06110 ENOG4108RWI nicotinamidase H0S62_RS06115 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H0S62_RS06135 ENOG4105S64 Formate nitrite transporter H0S62_RS06140 ENOG4105D1H recombination factor protein RarA H0S62_RS06150 ENOG4108ZZ3 UPF0260 protein H0S62_RS06170 ENOG4105CEN a g-specific adenine glycosylase H0S62_RS06185 ENOG4108R3E Dna-3-methyladenine glycosylase i H0S62_RS06190 ENOG4105DQ4 alcohol dehydrogenase H0S62_RS06210 ENOG4105HEI LysR family (Transcriptional regulator H0S62_RS06215 ENOG4105CV8 reductase H0S62_RS06220 ENOG4105F27 Major Facilitator H0S62_RS06255 ENOG4105DJY efflux transporter, rnd family, mfp subunit H0S62_RS06260 ENOG4108IG5 Transcriptional regulator H0S62_RS06270 ENOG4105C2W permease H0S62_RS06275 ENOG4108W5M transcriptional regulator H0S62_RS06300 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B H0S62_RS06310 ENOG4105C8J )-transporter H0S62_RS06365 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) H0S62_RS06370 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) H0S62_RS06375 ENOG4105D74 hydrolase H0S62_RS06385 ENOG4108821 RND type efflux pump H0S62_RS06390 ENOG4108821 RND type efflux pump H0S62_RS06395 ENOG4108821 RND type efflux pump H0S62_RS06400 ENOG4105C5H ABC transporter H0S62_RS06405 ENOG4105DQR SNARE associated Golgi H0S62_RS06415 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H0S62_RS06425 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) H0S62_RS06455 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins H0S62_RS06470 ENOG4105PGM cation diffusion facilitator family transporter H0S62_RS06475 ENOG4105T95 Thiol disulfide interChange protein H0S62_RS06485 ENOG4108UGV hypoxanthine phosphoribosyltransferase H0S62_RS06490 ENOG4107QUY Guanine deaminase H0S62_RS06510 ENOG4105DU1 integral membrane protein, terc H0S62_RS06515 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase H0S62_RS06530 ENOG4105DFU Cell wall formation (By similarity) H0S62_RS06540 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) H0S62_RS06545 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit H0S62_RS06550 ENOG4105CVE Lytic murein transglycosylase H0S62_RS06615 ENOG4105D5G Transposase H0S62_RS06630 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) H0S62_RS06670 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase H0S62_RS06680 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) H0S62_RS06685 ENOG4105DTN riboflavin biosynthesis protein ribF H0S62_RS06695 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) H0S62_RS06700 ENOG4108R86 Transcriptional regulator H0S62_RS06705 ENOG4108VM9 ABC, transporter H0S62_RS06710 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component H0S62_RS06715 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) H0S62_RS06720 ENOG4105GVF (ABC) transporter H0S62_RS06725 ENOG4105GVF (ABC) transporter H0S62_RS06730 ENOG4107QZM n-acetylglutamate synthase H0S62_RS06745 ENOG4105UBK short-chain dehydrogenase reductase H0S62_RS06750 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) H0S62_RS06760 ENOG4108Z33 Thiol disulfide Interchange Protein H0S62_RS06765 ENOG41062JF Transcriptional regulator H0S62_RS06790 ENOG4105HSS phospholipase C H0S62_RS06800 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase H0S62_RS06805 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase H0S62_RS06810 ENOG4105CJR Integral membrane protein (MviN H0S62_RS06815 ENOG4108V1T peptidylprolyl cis-trans isomerase H0S62_RS06820 ENOG4108V1T peptidylprolyl cis-trans isomerase H0S62_RS06825 ENOG4105D75 Capsular exopolysaccharide family H0S62_RS06835 ENOG4105DAY polysaccharide export protein H0S62_RS06840 ENOG4107QQG Dehydrogenase H0S62_RS06845 ENOG4105C5E polysaccharide biosynthesis protein H0S62_RS06850 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase H0S62_RS06855 ENOG4105F0R Cytidylyltransferase H0S62_RS06900 ENOG4108RYC glycosyltransferase H0S62_RS06905 ENOG4105D3Q Sugar transferase H0S62_RS06910 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase H0S62_RS06915 ENOG4105C6Y Udp-glucose 6-dehydrogenase H0S62_RS06925 ENOG4105CMR udp-glucose 4-epimerase H0S62_RS06940 ENOG4107QKV phosphomannomutase H0S62_RS06945 ENOG4105DAA L-lactate H0S62_RS06950 ENOG41073TP transcriptional regulator H0S62_RS06960 ENOG4105CXG d-lactate dehydrogenase H0S62_RS06965 ENOG4105CGF Aromatic amino acid aminotransferase H0S62_RS06975 ENOG4105DRR Transcriptional regulator, GntR family H0S62_RS06980 ENOG4105CR4 methylisocitrate lyase H0S62_RS06985 ENOG4105BZN citrate synthase H0S62_RS06990 ENOG4108I0Z Aconitate hydratase H0S62_RS07020 ENOG4105D3G Pseudouridine synthase H0S62_RS07045 ENOG4105EW9 transcriptional regulator AsnC family H0S62_RS07060 ENOG4105M4H endoribonuclease L-psp H0S62_RS07065 ENOG4105C85 amino acid H0S62_RS07070 ENOG4105C85 amino acid H0S62_RS07100 ENOG4105KRQ Addiction module toxin, Txe YoeB family H0S62_RS07110 ENOG4105C0D helicase H0S62_RS07120 ENOG4105ZTP Protein of unknown function (DUF1376) H0S62_RS07155 ENOG4107PSF BolA-like protein H0S62_RS07165 ENOG4107QJE Chromosome Partitioning Protein H0S62_RS07180 ENOG4105DQR SNARE associated Golgi H0S62_RS07185 ENOG4108VBZ doxx family H0S62_RS07190 ENOG4106MP8 UPF0754 membrane protein H0S62_RS07195 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) H0S62_RS07215 ENOG4105EUB pirin domain protein H0S62_RS07240 ENOG4107R1I NAD-dependent malic enzyme H0S62_RS07245 ENOG4105EZR dyp-type peroxidase family protein H0S62_RS07250 ENOG410829K Lysine exporter protein (Lyse ygga) H0S62_RS07255 ENOG4105FAV ABC, transporter H0S62_RS07260 ENOG4105FDK ABC transporter H0S62_RS07345 ENOG4105C79 DNA protecting protein DprA H0S62_RS07380 ENOG4105Y7M Transcriptional regulator, TetR family H0S62_RS07415 ENOG4105C6T cysteine synthase H0S62_RS07425 ENOG4105CS1 NAD(P)H quinone oxidoreductase H0S62_RS07445 ENOG4105CCT upf0313 protein H0S62_RS07460 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) H0S62_RS07470 ENOG4105C0R drug resistance transporter emrb qaca subfamily H0S62_RS07475 ENOG4108URH decarboxylase H0S62_RS07480 ENOG4105EE5 Membrane protein terC H0S62_RS07485 ENOG4105K5B UPF0225 protein H0S62_RS07490 ENOG4105EN6 Membrane H0S62_RS07495 ENOG41079KZ Major Facilitator Superfamily H0S62_RS07500 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H0S62_RS07505 ENOG4105CEY Amp-dependent synthetase and ligase H0S62_RS07520 ENOG4105F0N pyrophosphate phospho-hydrolase H0S62_RS07525 ENOG4105EPF Outer membrane porin H0S62_RS07535 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H0S62_RS07540 ENOG4105FB2 class II Aldolase H0S62_RS07545 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H0S62_RS07550 ENOG4105C0P Mg chelatase subunit ChlI H0S62_RS07675 ENOG4105C0P Mg chelatase subunit ChlI H0S62_RS07690 ENOG4105BZU Histidine kinase H0S62_RS07700 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) H0S62_RS07745 ENOG4108K5H permease YjgP YjgQ family protein H0S62_RS07750 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) H0S62_RS07755 ENOG4105CN1 protease H0S62_RS07760 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H0S62_RS07765 ENOG4107TUY Histidine kinase H0S62_RS07775 ENOG41061WM D-Alanyl-D-Alanine H0S62_RS07785 ENOG4105D6E homoserine dehydrogenase H0S62_RS07790 ENOG4105T95 Thiol disulfide interChange protein H0S62_RS07795 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H0S62_RS07805 ENOG4105CE1 Ferrous iron transport protein b H0S62_RS07820 ENOG4105CNI cell division protein FtsW H0S62_RS07825 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) H0S62_RS07835 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) H0S62_RS07860 ENOG4108RNG Permease of the drug metabolite transporter H0S62_RS07865 ENOG4105DFG type I secretion outer membrane protein H0S62_RS07870 ENOG4108UTW Plays a role in the regulation of phosphate uptake H0S62_RS07900 ENOG4108NEV two component transcriptional regulator, LytTR family H0S62_RS07905 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) H0S62_RS07930 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS H0S62_RS07945 ENOG4105GVR general secretion pathway protein D H0S62_RS07950 ENOG4105TV9 FHA Domain-Containing protein H0S62_RS07955 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) H0S62_RS07995 ENOG4105PM1 preprotein translocase subunit SecE H0S62_RS08000 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) H0S62_RS08050 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) H0S62_RS08055 ENOG4105D3Y Na H antiporter H0S62_RS08070 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) H0S62_RS08085 ENOG4107ZXU DSBA oxidoreductase H0S62_RS08145 ENOG4105D5G Transposase H0S62_RS08155 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase H0S62_RS08160 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) H0S62_RS08190 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) H0S62_RS08200 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) H0S62_RS08215 ENOG4105C2N RNA methyltransferase TrmH family group 3 H0S62_RS08225 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) H0S62_RS08240 ENOG4107QHF type ii secretion system protein e H0S62_RS08250 ENOG4107EJC Preprotein translocase subunit SecG H0S62_RS08275 ENOG4105CHV Transcription elongation factor NusA H0S62_RS08290 ENOG4105KJM monovalent cation h antiporter subunit g H0S62_RS08295 ENOG4105W4C monovalent cation H antiporter subunit F H0S62_RS08300 ENOG4105SC1 monovalent cation H antiporter subunit E H0S62_RS08305 ENOG4107R4Z monovalent cation h antiporter subunit d H0S62_RS08310 ENOG4108ZE9 Monovalent cation H antiporter subunit C H0S62_RS08315 ENOG4105D65 subunit l H0S62_RS08330 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase H0S62_RS08335 ENOG41061H0 Monooxygenase H0S62_RS08350 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) H0S62_RS08360 ENOG4105CSR polyphosphate kinase 2 H0S62_RS08370 ENOG4105DSY exodeoxyribonuclease V, gamma H0S62_RS08375 ENOG4107QKA exodeoxyribonuclease V beta H0S62_RS08380 ENOG4107QYX exodeoxyribonuclease v alpha H0S62_RS08400 ENOG4107QUT magnesium and cobalt transport protein CorA H0S62_RS08405 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) H0S62_RS08410 ENOG4105DVC DnaJ domain protein H0S62_RS08425 ENOG4105CKD glutathione-regulated potassium-efflux system protein H0S62_RS08430 ENOG4105C25 Primosomal protein n' H0S62_RS08435 ENOG4105D7Q type ii secretion system H0S62_RS08440 ENOG4108VAU general secretion pathway protein G H0S62_RS08450 ENOG4108Z7R Chaperone CsaA H0S62_RS08455 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) H0S62_RS08460 ENOG4108JU5 Magnesium and cobalt efflux protein H0S62_RS08465 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) H0S62_RS08470 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase H0S62_RS08480 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) H0S62_RS08495 ENOG4105C5X domain protein H0S62_RS08500 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) H0S62_RS08510 ENOG4105BZ8 glutamate synthase H0S62_RS08545 ENOG4107T8P acyl-Coa dehydrogenase H0S62_RS08555 ENOG4107QI1 Mate efflux family protein H0S62_RS08565 ENOG4105CSA Coproporphyrinogen iii oxidase H0S62_RS08595 ENOG4105J5T Amp-dependent synthetase and ligase H0S62_RS08600 ENOG4105C03 ribonuclease H0S62_RS08605 ENOG4105EI2 Pseudouridine synthase H0S62_RS08610 ENOG4107XGZ Hydrolase H0S62_RS08615 ENOG4105D29 Helix-turn-helix type 11 domain protein H0S62_RS08630 ENOG4108W5M transcriptional regulator H0S62_RS08645 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase H0S62_RS08660 ENOG4105DUM transcriptional regulator, lysR family H0S62_RS08685 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) H0S62_RS08755 ENOG4105CK2 sodium dicarboxylate symporter H0S62_RS08765 ENOG4105D1S lipid A biosynthesis H0S62_RS08770 ENOG4105N14 lysine exporter protein LysE YggA H0S62_RS08775 ENOG4105C5H ABC transporter H0S62_RS08790 ENOG4105KVH Transcriptional regulator H0S62_RS08800 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) H0S62_RS08815 ENOG4105C4R Atp-dependent dna helicase H0S62_RS08820 ENOG4105VFU Rna-binding protein H0S62_RS08840 ENOG4105CKD glutathione-regulated potassium-efflux system protein H0S62_RS08855 ENOG4107RGH Aldehyde dehydrogenase H0S62_RS08865 ENOG4105CIY formyltetrahydrofolate deformylase H0S62_RS08980 ENOG4105DWV Homoserine O-trans-acetylase H0S62_RS08990 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) H0S62_RS09000 ENOG4108ESX Receptor H0S62_RS09010 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) H0S62_RS09030 ENOG4107GFK fumarate H0S62_RS09035 ENOG4108DNC Involved in acetate metabolism (By similarity) H0S62_RS09040 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) H0S62_RS09045 ENOG4105C01 Dihydroxy-acid dehydratase H0S62_RS09050 ENOG4108UHU Aldolase H0S62_RS09055 ENOG4105C6Z Gluconate H0S62_RS09060 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family H0S62_RS09065 ENOG4105C26 Dehydrogenase H0S62_RS09075 ENOG4106HB6 Alpha beta hydrolase H0S62_RS09090 ENOG4105CN1 protease H0S62_RS09105 ENOG4105WVQ Fe-S assembly protein IscX H0S62_RS09125 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) H0S62_RS09145 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) H0S62_RS09165 ENOG4105VW4 glutaredoxin 3 H0S62_RS09175 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) H0S62_RS09180 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) H0S62_RS09190 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH H0S62_RS09195 ENOG4105ENJ RND efflux system, outer membrane lipoprotein H0S62_RS09200 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) H0S62_RS09205 ENOG4105DJY efflux transporter, rnd family, mfp subunit H0S62_RS09230 ENOG4105C7K acetolactate synthase H0S62_RS09235 ENOG4108ZP8 Acetolactate synthase small subunit H0S62_RS09245 ENOG4105BZU Histidine kinase H0S62_RS09275 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) H0S62_RS09290 ENOG4105F8V Hydrolase, tatD family H0S62_RS09295 ENOG4107QM5 aconitate hydratase H0S62_RS09300 ENOG4105CUZ uba thif-type nad fad binding protein H0S62_RS09310 ENOG4107RSM transcriptional regulator H0S62_RS09320 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) H0S62_RS09335 ENOG4106UX7 integral membrane protein H0S62_RS09340 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) H0S62_RS09345 ENOG4105W8H transhydrogenase (subunit alpha H0S62_RS09350 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) H0S62_RS09365 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) H0S62_RS09370 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H0S62_RS09375 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase H0S62_RS09380 ENOG4105BZU Histidine kinase H0S62_RS09385 ENOG4105C6T cysteine synthase H0S62_RS09400 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) H0S62_RS09410 ENOG4105DXN mazG family H0S62_RS09420 ENOG4105DJ0 Poly(A) Polymerase H0S62_RS09425 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase H0S62_RS09445 ENOG41080Z8 PHOSPHOCARRIER protein H0S62_RS09450 ENOG4105N42 UPF0307 protein H0S62_RS09455 ENOG4105CEY Amp-dependent synthetase and ligase H0S62_RS09470 ENOG4105CYM Glutathione S-transferase H0S62_RS09475 ENOG4105W39 Membrane H0S62_RS09525 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) H0S62_RS09545 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) H0S62_RS09555 ENOG4105C9X ppx gppa phosphatase H0S62_RS09565 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) H0S62_RS09570 ENOG4105II7 pyrroline-5-carboxylate reductase H0S62_RS09575 ENOG4108VIA integral membrane protein H0S62_RS09580 ENOG4105C2M dna polymerase I H0S62_RS09600 ENOG4107QHF type ii secretion system protein e H0S62_RS09605 ENOG4108ZHJ Organic hydroperoxide resistance protein H0S62_RS09610 ENOG4105K56 Transcriptional regulator H0S62_RS09680 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) H0S62_RS09685 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) H0S62_RS09690 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) H0S62_RS09700 ENOG4105CRQ synthase (Component I) H0S62_RS09710 ENOG4105D5G Transposase H0S62_RS09725 ENOG4108Z0R Transferase H0S62_RS09730 ENOG41072GX Peptidase M22 Glycoprotease H0S62_RS09745 ENOG4105C4W S-formylglutathione hydrolase H0S62_RS09755 ENOG4105DJV ribulose-phosphate 3-epimerase H0S62_RS09760 ENOG4108HCJ Hydrolase H0S62_RS09770 ENOG4105E3B Multicopper oxidase H0S62_RS09775 ENOG4105VR0 copper resistance H0S62_RS09790 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) H0S62_RS09795 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) H0S62_RS09800 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) H0S62_RS09835 ENOG4105ED4 portal protein H0S62_RS09880 ENOG4108E1C hydrolase H0S62_RS10090 ENOG4107R08 Integrase H0S62_RS10120 ENOG4106P55 Transcriptional regulator H0S62_RS10130 ENOG4105ETT transcriptional Regulator, LysR family H0S62_RS10145 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) H0S62_RS10160 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H0S62_RS10170 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H0S62_RS10180 ENOG4107EXC regulatoR H0S62_RS10185 ENOG4105E0F Histidine kinase H0S62_RS10195 ENOG4105BZU Histidine kinase H0S62_RS10215 ENOG4105GKE subunit e H0S62_RS10220 ENOG4107QIZ NADH dehydrogenase H0S62_RS10225 ENOG4108IEH NADH dehydrogenase subunit g H0S62_RS10240 ENOG4107UFS subunit j H0S62_RS10250 ENOG4105D65 subunit l H0S62_RS10255 ENOG4105C8S subunit m H0S62_RS10275 ENOG4105DUM transcriptional regulator, lysR family H0S62_RS10280 ENOG4105DP0 ferredoxin-NADP reductase H0S62_RS10305 ENOG4105CBX hi0933 family H0S62_RS10310 ENOG4105K6H D-cysteine desulfhydrase H0S62_RS10340 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) H0S62_RS10350 ENOG4105D1F ATP-binding protein H0S62_RS10400 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) H0S62_RS10410 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY H0S62_RS10425 ENOG4105HF0 Membrane H0S62_RS10435 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) H0S62_RS10455 ENOG4106UW1 Major Facilitator superfamily H0S62_RS10460 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase H0S62_RS10465 ENOG4108K4C ec 3.1.3.12 H0S62_RS10470 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) H0S62_RS10480 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) H0S62_RS10485 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) H0S62_RS10500 ENOG4105FE9 pseudouridine synthase H0S62_RS10505 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) H0S62_RS10510 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) H0S62_RS10515 ENOG4107RTD sua5 ycio yrdc ywlc family protein H0S62_RS10520 ENOG4108BPE -transporting atpase H0S62_RS10525 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein H0S62_RS10535 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase H0S62_RS10540 ENOG4105CHR reductase H0S62_RS10550 ENOG4109066 lysm domain bon superfamily protein H0S62_RS10555 ENOG4105DWF phosphomethylpyrimidine kinase H0S62_RS10575 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) H0S62_RS10615 ENOG4105C5T Phosphoribosyl pyrophosphate synthase H0S62_RS10645 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) H0S62_RS10660 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) H0S62_RS10665 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane H0S62_RS10670 ENOG4105C34 Pseudouridine synthase H0S62_RS10675 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase H0S62_RS11015 ENOG4105DFP Integrase H0S62_RS11025 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding H0S62_RS11045 ENOG4105EJC lysr family transcriptional regulator H0S62_RS11050 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) H0S62_RS11055 ENOG4105C94 Transporter H0S62_RS11065 ENOG4105DVW rieske (2Fe-2S) H0S62_RS11070 ENOG4105C26 Dehydrogenase H0S62_RS11075 ENOG4105E3J oxidoreductase H0S62_RS11105 ENOG4105C4K Nad synthetase H0S62_RS11115 ENOG4105EUB pirin domain protein H0S62_RS11120 ENOG4108YXA Membrane H0S62_RS11165 ENOG4105KEG ribosomal-protein-alanine acetyltransferase H0S62_RS11175 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) H0S62_RS11180 ENOG4105C3M thioredoxin reductase H0S62_RS11185 ENOG4105CNU cell division protein FtsK H0S62_RS11190 ENOG4105CCF Lysine exporter protein (Lyse ygga) H0S62_RS11205 ENOG4107QMS site-determining protein H0S62_RS11220 ENOG4106HNH Acyl-transferase H0S62_RS11225 ENOG4108ZG0 Ompa motb domain protein H0S62_RS11230 ENOG4105C4R Atp-dependent dna helicase H0S62_RS11240 ENOG4107QKV phosphomannomutase H0S62_RS11255 ENOG4105E7A Glutamine amidotransferase H0S62_RS11280 ENOG41090R7 Ferric uptake H0S62_RS11285 ENOG4105CZX twitching motility protein H0S62_RS11290 ENOG4105CZX twitching motility protein H0S62_RS11295 ENOG4105DFA alanine racemase domain protein H0S62_RS11300 ENOG4105EYH Exonuclease H0S62_RS11305 ENOG4107RH8 nuclease SbcCD subunit D H0S62_RS11325 ENOG4105ECP epimerase H0S62_RS11330 ENOG4105MWK D-amino acid dehydrogenase, small subunit H0S62_RS11335 ENOG4105D52 delta-aminolevulinic acid dehydratase H0S62_RS11340 ENOG4108VUY thioesterase Superfamily protein H0S62_RS11345 ENOG4105CW7 secretion protein, HlyD family H0S62_RS11350 ENOG4105C0R drug resistance transporter emrb qaca subfamily H0S62_RS11355 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) H0S62_RS11365 ENOG4105DFP Integrase H0S62_RS11445 ENOG4105C54 Major Facilitator superfamily H0S62_RS11450 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H0S62_RS11475 ENOG4105D5Q Arginine ornithine antiporter H0S62_RS11480 ENOG4107QK5 Homocysteine s-methyltransferase H0S62_RS11505 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) H0S62_RS11510 ENOG4105C94 Transporter H0S62_RS11515 ENOG4105C94 Transporter H0S62_RS11525 ENOG4108S4H thioesterase Superfamily protein H0S62_RS11535 ENOG4105CKI cobalamin synthesis protein H0S62_RS11555 ENOG4108VWS Yaeq family H0S62_RS11565 ENOG4107BJW polysaccharide deacetylase H0S62_RS11570 ENOG4105CND Glycosyl transferase, family 2 H0S62_RS11580 ENOG4106YT9 Enoyl-CoA hydratase H0S62_RS11595 ENOG41069M3 Transcriptional regulator H0S62_RS11615 ENOG4105CHR reductase H0S62_RS11625 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase H0S62_RS11630 ENOG4105DJB Major Facilitator Superfamily H0S62_RS11640 ENOG4108MXF Alpha Beta Hydrolase H0S62_RS11645 ENOG4105CHR reductase H0S62_RS11660 ENOG4105C7K acetolactate synthase H0S62_RS11670 ENOG4105CSH Transporter H0S62_RS11675 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) H0S62_RS11680 ENOG4105CSV Glutaminase H0S62_RS11685 ENOG4108R6W Transcriptional regulator, ARAC family H0S62_RS11690 ENOG4105EU0 Major facilitator Superfamily H0S62_RS11695 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) H0S62_RS11705 ENOG4108PZW LysR family Transcriptional regulator H0S62_RS11715 ENOG4105CSP Major Facilitator Superfamily H0S62_RS11730 ENOG4105C3R Methionine synthase H0S62_RS11735 ENOG4105CJ3 phosphate transporter H0S62_RS11755 ENOG4105E6M Sulphatase-modifying factor protein H0S62_RS11760 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) H0S62_RS11775 ENOG4107RNH Outer membrane receptor FepA H0S62_RS11795 ENOG4108UJV acyl-CoA thioesterase i H0S62_RS11800 ENOG4108I0Y (ABC) transporter H0S62_RS11805 ENOG4105CV6 ABC transporter, permease H0S62_RS11810 ENOG4107U91 Rhomboid family H0S62_RS11835 ENOG4105C5Q Transcriptional regulator H0S62_RS11845 ENOG4107QZF nitrite reductase NADPH large subunit H0S62_RS11850 ENOG4105VCQ rubredoxin H0S62_RS11870 ENOG4108MRJ H0S62_RS11885 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) H0S62_RS11900 ENOG4105D4T Citrate transporter H0S62_RS11905 ENOG4105C37 (CBS) domain H0S62_RS11915 ENOG4107RET Isocitrate lyase H0S62_RS11950 ENOG4105CQM Urea amidohydrolase subunit alpha H0S62_RS11960 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) H0S62_RS11975 ENOG4106H78 methyltransferase H0S62_RS11980 ENOG4105CJN penicillin-binding protein H0S62_RS12005 ENOG4105CSM endonuclease III H0S62_RS12010 ENOG4108R3D Electron transport complex H0S62_RS12015 ENOG4105D82 Glutamate dehydrogenase H0S62_RS12025 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b H0S62_RS12045 ENOG4105D5G Transposase H0S62_RS12060 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase H0S62_RS12115 ENOG41083X2 DNA polymerase III, epsilon subunit H0S62_RS12410 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) H0S62_RS12485 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) H0S62_RS12490 ENOG4105KT5 UmuD protein H0S62_RS12530 ENOG4107RAQ aminopeptidase H0S62_RS12535 ENOG4105D0A hydroxylase H0S62_RS12540 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family H0S62_RS12560 ENOG4108ZUB Lysine exporter protein (Lyse ygga) H0S62_RS12565 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) H0S62_RS12575 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) H0S62_RS12585 ENOG4105W4M Transport-associated protein H0S62_RS12595 ENOG4105E09 nadh pyrophosphatase H0S62_RS12605 ENOG4107RZZ dna polymerase iii epsilon subunit H0S62_RS12610 ENOG4105E9H Lytic Murein transglycosylase H0S62_RS12610 ENOG4105E9H Lytic Murein transglycosylase H0S62_RS12620 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component H0S62_RS12625 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component H0S62_RS12630 ENOG4108JQ5 ABC transporter H0S62_RS12650 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) H0S62_RS12670 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H0S62_RS12685 ENOG4108M3P Membrane H0S62_RS12695 ENOG4105D01 (LipO)protein H0S62_RS12720 ENOG4106B0W Curli production assembly transport component CsgG H0S62_RS12730 ENOG4107Y60 (LipO)protein H0S62_RS12740 ENOG4105C85 amino acid H0S62_RS12750 ENOG4105CUB amino acid H0S62_RS12770 ENOG4105C26 Dehydrogenase H0S62_RS12825 ENOG4105C7N Xanthine uracil vitamin C permease H0S62_RS12830 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) H0S62_RS12850 ENOG4105CPW cytochrome b561 H0S62_RS12860 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) H0S62_RS12870 ENOG4105CFH Aspartokinase H0S62_RS12880 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase H0S62_RS12890 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis H0S62_RS12905 ENOG4105CPC Aldo Keto reductase H0S62_RS12910 ENOG4107RYR Transcriptional regulator, Crp Fnr family H0S62_RS12915 ENOG4108UKZ OsmC family H0S62_RS12930 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H0S62_RS12960 ENOG4105CD3 dihydroorotase H0S62_RS12965 ENOG4108ZG0 Ompa motb domain protein H0S62_RS12975 ENOG4108TGY Glutathione S-transferase H0S62_RS13005 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) H0S62_RS13015 ENOG4108K3A Glutathione S-transferase H0S62_RS13025 ENOG4108JU3 Alkyl hydroperoxide reductase H0S62_RS13035 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) H0S62_RS13045 ENOG4105D3R alkyl hydroperoxide reductase H0S62_RS13050 ENOG4105CQ7 ATP-dependent helicase H0S62_RS13065 ENOG4105D2S major facilitator superfamily H0S62_RS13070 ENOG4105DKK Benzoate H0S62_RS13075 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase H0S62_RS13080 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein H0S62_RS13085 ENOG4108UKV benzoate 1,2-dioxygenase H0S62_RS13090 ENOG4105FUY alpha subunit H0S62_RS13095 ENOG4108KB2 LysR family Transcriptional regulator H0S62_RS13145 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) H0S62_RS13180 ENOG410829K Lysine exporter protein (Lyse ygga) H0S62_RS13190 ENOG4105VEQ Cold shock protein H0S62_RS13205 ENOG4105II7 pyrroline-5-carboxylate reductase H0S62_RS13235 ENOG4105D5G Transposase H0S62_RS13285 ENOG4105C2X Arabinose 5-phosphate isomerase H0S62_RS13300 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA H0S62_RS13305 ENOG4108IUZ ABC transporter H0S62_RS13310 ENOG4105DFG type I secretion outer membrane protein H0S62_RS13350 ENOG4108Z4U Ferredoxin H0S62_RS13425 ENOG4105D1S lipid A biosynthesis H0S62_RS13435 ENOG4105D2S major facilitator superfamily H0S62_RS13450 ENOG4105D7T ABC transporter H0S62_RS13455 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component H0S62_RS13460 ENOG4106FTQ Taurine ABC transporter, periplasmic H0S62_RS13490 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) H0S62_RS13545 ENOG4108WAV Transcriptional regulator H0S62_RS13550 ENOG4105C5A transporter H0S62_RS13570 ENOG4108JIK carboxylase H0S62_RS13575 ENOG4107R4J Chloride channel H0S62_RS13605 ENOG4105E2A Dehydrogenase H0S62_RS13625 ENOG4105WPN DNA integration recombination invertion protein H0S62_RS13635 ENOG4108Z4X TRANSCRIPTIONal H0S62_RS13645 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H0S62_RS13665 ENOG4105MWK D-amino acid dehydrogenase, small subunit H0S62_RS13700 ENOG4105CZJ Aldehyde dehydrogenase H0S62_RS13705 ENOG4107QTZ amino acid H0S62_RS13715 ENOG4105DXM phenylacetic acid degradation protein H0S62_RS13720 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit H0S62_RS13725 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit H0S62_RS13730 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit H0S62_RS13735 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit H0S62_RS13740 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) H0S62_RS13745 ENOG4105E39 Enoyl-CoA hydratase H0S62_RS13750 ENOG4108UKI Enoyl-CoA hydratase H0S62_RS13760 ENOG4105CHU acetyl-coa acetyltransferase H0S62_RS13765 ENOG4105DZS Phenylacetate-CoA ligase H0S62_RS13770 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein H0S62_RS13780 ENOG4107YAU phenylacetic acid degradation protein H0S62_RS13795 ENOG4108TGR phosphatase H0S62_RS13815 ENOG41082JN Transcriptional regulator H0S62_RS13830 ENOG4108ZX5 transcriptional regulator H0S62_RS13840 ENOG4105CRN Aminoglycoside phosphotransferase H0S62_RS13845 ENOG4105D5Q Arginine ornithine antiporter H0S62_RS13850 ENOG4107VGR Catalase H0S62_RS13855 ENOG4105CPW cytochrome b561 H0S62_RS13875 ENOG4108MXF Alpha Beta Hydrolase H0S62_RS13880 ENOG4105MXW flavin reductase domain protein, FMN-binding H0S62_RS13885 ENOG4108M8W Monooxygenase H0S62_RS13890 ENOG4105C26 Dehydrogenase H0S62_RS13900 ENOG4105ETS cytosine purines uracil thiamine allantoin H0S62_RS13910 ENOG4105C26 Dehydrogenase H0S62_RS13915 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase H0S62_RS13920 ENOG4105HEI LysR family (Transcriptional regulator H0S62_RS13930 ENOG4107HP6 Transcriptional regulator H0S62_RS13935 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase H0S62_RS13945 ENOG4105C4Y ABC transporter H0S62_RS13950 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H0S62_RS13955 ENOG4107RCV ABC transporter, permease H0S62_RS13965 ENOG4107STF Involved in phosphonate degradation (By similarity) H0S62_RS13970 ENOG4108KAZ Involved in phosphonate degradation (By similarity) H0S62_RS13975 ENOG4107RGD Major Facilitator superfamily H0S62_RS13980 ENOG4105C1G acyl-Coa dehydrogenase H0S62_RS13995 ENOG4108UKI Enoyl-CoA hydratase H0S62_RS14000 ENOG4105EA8 2-Nitropropane dioxygenase H0S62_RS14025 ENOG4105CHU acetyl-coa acetyltransferase H0S62_RS14030 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H0S62_RS14035 ENOG4105CHR reductase H0S62_RS14040 ENOG4105E39 Enoyl-CoA hydratase H0S62_RS14045 ENOG4105C1G acyl-Coa dehydrogenase H0S62_RS14050 ENOG4107RGD Major Facilitator superfamily H0S62_RS14055 ENOG4107QP7 CoA-transferase subunit A H0S62_RS14060 ENOG4107QNJ CoA-transferase subunit B H0S62_RS14090 ENOG4105CSU acyl-Coa dehydrogenase H0S62_RS14105 ENOG4105CC0 LysR family Transcriptional regulator H0S62_RS14125 ENOG4105E39 Enoyl-CoA hydratase H0S62_RS14130 ENOG4107QX3 carboxylase H0S62_RS14135 ENOG4105C1G acyl-Coa dehydrogenase H0S62_RS14140 ENOG4105R8C Transcriptional regulator H0S62_RS14145 ENOG4105CEY Amp-dependent synthetase and ligase H0S62_RS14165 ENOG4105HEI LysR family (Transcriptional regulator H0S62_RS14250 ENOG4105CYX Short-chain dehydrogenase reductase Sdr H0S62_RS14270 ENOG4105KT5 UmuD protein H0S62_RS14280 ENOG4105EW9 transcriptional regulator AsnC family H0S62_RS14290 ENOG4105BZU Histidine kinase H0S62_RS14295 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase H0S62_RS14310 ENOG4105EAD ABC transporter H0S62_RS14315 ENOG4108HW4 amino acid AbC transporter H0S62_RS14320 ENOG4105CDA abc transporter atp-binding protein H0S62_RS14325 ENOG4107RP9 extracellular solute-binding protein, family 3 H0S62_RS14330 ENOG4105CT1 (ABC) transporter H0S62_RS14340 ENOG4105EXG Transcriptional regulator H0S62_RS14345 ENOG4105CCF Lysine exporter protein (Lyse ygga) H0S62_RS14375 ENOG4105ESN nucleotide-binding protein H0S62_RS14380 ENOG4105D7W serine acetyltransferase H0S62_RS14390 ENOG4105CHR reductase H0S62_RS14395 ENOG4105CBN LysR family transcriptional regulator H0S62_RS14400 ENOG4105CYM Glutathione S-transferase H0S62_RS14405 ENOG4108SHQ Glutathione S-transferase H0S62_RS14410 ENOG4105CMU LysR family (Transcriptional regulator H0S62_RS14415 ENOG4105VAW lrga family H0S62_RS14420 ENOG41067MG lrgb family H0S62_RS14440 ENOG4105DXI Major Facilitator superfamily H0S62_RS14475 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase H0S62_RS14480 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) H0S62_RS14495 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase H0S62_RS14500 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase H0S62_RS14515 ENOG4108K70 Transcriptional regulator H0S62_RS14520 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H0S62_RS14530 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii H0S62_RS14535 ENOG4105C4M (Ubiquinol oxidase) subunit I H0S62_RS14555 ENOG4105C54 Major Facilitator superfamily H0S62_RS14565 ENOG4106FTQ Taurine ABC transporter, periplasmic H0S62_RS14570 ENOG4108IY8 ABC, transporter H0S62_RS14575 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component H0S62_RS14590 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease H0S62_RS14600 ENOG4105CBN LysR family transcriptional regulator H0S62_RS14610 ENOG4105CPN adenine deaminase H0S62_RS14625 ENOG41082YX Transcriptional regulator, arsr family H0S62_RS14630 ENOG4105D6J arsenicaL-resistance protein H0S62_RS14635 ENOG4108KB2 LysR family Transcriptional regulator H0S62_RS14650 ENOG4108JU3 Alkyl hydroperoxide reductase H0S62_RS14675 ENOG4105C0B DNA polymerase III (alpha subunit) H0S62_RS14705 ENOG4105CHM Aminotransferase H0S62_RS14715 ENOG4108V06 Glutathione peroxidase H0S62_RS14720 ENOG4105E7U AraC family transcriptional regulator H0S62_RS14750 ENOG4105ZED uncharacterized protein ygaH H0S62_RS14755 ENOG4108UMN azlc family H0S62_RS14780 ENOG4105C3G gtp-binding protein H0S62_RS14785 ENOG4108UMI ABC transporter, permease H0S62_RS14790 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) H0S62_RS14795 ENOG4105D01 (LipO)protein H0S62_RS14800 ENOG4105D01 (LipO)protein H0S62_RS14815 ENOG4107T8P acyl-Coa dehydrogenase H0S62_RS14830 ENOG4105EAD ABC transporter H0S62_RS14835 ENOG4105DRP amino acid AbC transporter H0S62_RS14840 ENOG4105CDA abc transporter atp-binding protein H0S62_RS14850 ENOG4105EW9 transcriptional regulator AsnC family H0S62_RS14925 ENOG4105GQR Chaperone H0S62_RS14930 ENOG4105X0I Fimbrial H0S62_RS14950 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) H0S62_RS14955 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) H0S62_RS14975 ENOG4108HWY Beta-lactamase H0S62_RS15010 ENOG4105CV1 Transketolase (EC 2.2.1.1) H0S62_RS15020 ENOG4108YYC ycei family H0S62_RS15030 ENOG4108T58 Mg2 transport protein CorA H0S62_RS15045 ENOG4105YGK Pfam:UPF0157 H0S62_RS15050 ENOG4105C26 Dehydrogenase H0S62_RS15055 ENOG4105EW9 transcriptional regulator AsnC family H0S62_RS15060 ENOG4105CK7 Sodium proline symporter H0S62_RS15090 ENOG4108ZX5 transcriptional regulator H0S62_RS15100 ENOG4105BZ1 (ABC) transporter H0S62_RS15105 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme H0S62_RS15110 ENOG4105XPP Protein of unknown function (DUF1275) H0S62_RS15120 ENOG41080HT Transcriptional regulator, arsr family H0S62_RS15130 ENOG4105EZE Cupin 4 family protein H0S62_RS15135 ENOG4108UHJ MAF-like protein H0S62_RS15155 ENOG4105D2N Aldolase H0S62_RS15160 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) H0S62_RS15165 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) H0S62_RS15170 ENOG4105EHM Aminoglycoside phosphotransferase H0S62_RS15175 ENOG4108S0S Nucleotidyl transferase H0S62_RS15185 ENOG4107QJE Chromosome Partitioning Protein H0S62_RS15190 ENOG4105FA0 parb-like partition protein H0S62_RS15205 ENOG4105BZ1 (ABC) transporter H0S62_RS15210 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) H0S62_RS15220 ENOG4107QRG dna polymerase iii H0S62_RS15230 ENOG4105F8V Hydrolase, tatD family H0S62_RS15255 ENOG4108RTD type II secretion system protein K H0S62_RS15275 ENOG4108Z6B deaminase H0S62_RS15300 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) H0S62_RS15305 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) H0S62_RS15325 ENOG4105D5G Transposase H0S62_RS15330 ENOG4107RN6 Monooxygenase H0S62_RS15340 ENOG4105D6Z AFG1 family ATPase H0S62_RS15345 ENOG4107QP3 malate synthase g H0S62_RS15355 ENOG4105SG9 biopolymer transport protein, ExbD H0S62_RS15395 ENOG4105DGW oligopeptidase A H0S62_RS15405 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H0S62_RS15425 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase H0S62_RS15440 ENOG4105K4T epimerase H0S62_RS15445 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) H0S62_RS15465 ENOG4108JA2 transcriptioN-repair coupling factor H0S62_RS15475 ENOG4105F8J Adenylate Guanylate cyclase H0S62_RS15480 ENOG4108ZIT Ferredoxin, 2FE-2S H0S62_RS15495 ENOG4108Z4V iron-sulfur cluster assembly H0S62_RS15500 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins H0S62_RS15510 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family H0S62_RS15525 ENOG4105K70 DNA-binding protein H0S62_RS15530 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) H0S62_RS15535 ENOG4105E7U AraC family transcriptional regulator H0S62_RS15540 ENOG4105EEF Alkane 1-monooxygenase H0S62_RS15545 ENOG4105C1G acyl-Coa dehydrogenase H0S62_RS15550 ENOG4105C1G acyl-Coa dehydrogenase H0S62_RS15565 ENOG4108Z66 YbaK ebsC protein H0S62_RS15585 ENOG4105DUU IucA IucC family protein H0S62_RS15590 ENOG4105DJU Siderophore biosynthesis protein H0S62_RS15600 ENOG4105JSC dimethylmenaquinone methyltransferase H0S62_RS15630 ENOG4107VXZ Hydrolase H0S62_RS15640 ENOG4108YZT Adenosylcobinamide kinase H0S62_RS15645 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) H0S62_RS15650 ENOG4107TB6 phosphoglycerate mutase H0S62_RS15665 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) H0S62_RS15670 ENOG4107TSN permease H0S62_RS15690 ENOG4105CNM Receptor H0S62_RS15695 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H0S62_RS15710 ENOG4105CJ1 ABC, transporter H0S62_RS15715 ENOG4107QWP ABC-2 type transporter H0S62_RS15720 ENOG4107QWP ABC-2 type transporter H0S62_RS15745 ENOG4105K59 histidine triad (HIT) protein H0S62_RS15775 ENOG4105F2W methyltransferase H0S62_RS15790 ENOG4105C28 cystathionine H0S62_RS15810 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) H0S62_RS15855 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) H0S62_RS15860 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) H0S62_RS15870 ENOG4105BZU Histidine kinase H0S62_RS15890 ENOG4107R0V Pyruvate dehydrogenase H0S62_RS15895 ENOG4105CPP Dehydrogenase, E1 component H0S62_RS15910 ENOG4105CHR reductase H0S62_RS15920 ENOG4105FFC UPF0187 protein H0S62_RS15930 ENOG4107QPB Beta-lactamase domain protein H0S62_RS15940 ENOG4108VCT Sulfite exporter TauE/SafE H0S62_RS15955 ENOG4105UEI Transcriptional Regulator AraC Family H0S62_RS15960 ENOG4105KVH Transcriptional regulator H0S62_RS15965 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) H0S62_RS15990 ENOG4106FTQ Taurine ABC transporter, periplasmic H0S62_RS16005 ENOG4105CSH Transporter H0S62_RS16015 ENOG4108IJ0 Aspartate ammonia-lyase H0S62_RS16030 ENOG4107YNJ LysR family Transcriptional regulator H0S62_RS16070 ENOG4105CRW Short chain fatty acid transporter H0S62_RS16085 ENOG4108M0I Transcriptional regulator H0S62_RS16110 ENOG4108IND Tetr family transcriptional regulator H0S62_RS16120 ENOG4105CY2 Citrate transporter H0S62_RS16125 ENOG4105DTD Dehydrogenase H0S62_RS16130 ENOG4105CF7 AraC family transcriptional regulator H0S62_RS16135 ENOG4105D2S major facilitator superfamily H0S62_RS16145 ENOG4105CHR reductase H0S62_RS16170 ENOG4105F57 Anthranilate dioxygenase reductase H0S62_RS16175 ENOG4108YS2 small subunit H0S62_RS16185 ENOG4105F4R Transcriptional regulator mode H0S62_RS16190 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein H0S62_RS16195 ENOG4105E0C molybdate abc transporter H0S62_RS16200 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) H0S62_RS16205 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase H0S62_RS16210 ENOG4105WQI isochorismatase H0S62_RS16220 ENOG4107T31 5'-nucleotidase H0S62_RS16255 ENOG4108IGT Dipeptidase H0S62_RS16305 ENOG4105D5G Transposase H0S62_RS16340 ENOG4105X0I Fimbrial H0S62_RS16380 ENOG4105EZV Transcriptional regulator H0S62_RS16385 ENOG4105YES addiction module antidote protein H0S62_RS16390 ENOG4105VUH addiction module killer protein H0S62_RS16400 ENOG4105YES addiction module antidote protein H0S62_RS16405 ENOG4105VUH addiction module killer protein H0S62_RS16430 ENOG4105DJ2 Major Facilitator Superfamily H0S62_RS16465 ENOG4105E2A Dehydrogenase H0S62_RS16470 ENOG4108BUD transposase H0S62_RS16500 ENOG4105C4W S-formylglutathione hydrolase H0S62_RS16515 ENOG4108I6A alcohol dehydrogenase H0S62_RS16525 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H0S62_RS16535 ENOG4108WUH Transcriptional regulator, TetR family H0S62_RS16540 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein H0S62_RS16555 ENOG4107RT3 EamA-like transporter family H0S62_RS16575 ENOG4105VN1 Heat shock protein H0S62_RS16580 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H0S62_RS16625 ENOG4105KDM Diguanylate cyclase with gaf sensor H0S62_RS16680 ENOG4105F9F transposase H0S62_RS16715 ENOG4105D5G Transposase H0S62_RS16745 ENOG4105XUP Phage derived protein Gp49-like (DUF891) H0S62_RS16755 ENOG4105E0F Histidine kinase H0S62_RS16760 ENOG4108821 RND type efflux pump H0S62_RS16800 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) H0S62_RS16855 ENOG4108UAJ Transcriptional regulator H0S62_RS16895 ENOG4105C5T Phosphoribosyl pyrophosphate synthase H0S62_RS16915 ENOG4105E0A ABC, transporter H0S62_RS16920 ENOG4105EHG Permease protein H0S62_RS16930 ENOG4105DQ4 alcohol dehydrogenase H0S62_RS16935 ENOG4105CF7 AraC family transcriptional regulator H0S62_RS16940 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H0S62_RS16950 ENOG4105EXW epimerase dehydratase H0S62_RS16955 ENOG4105DDW LysR family Transcriptional regulator H0S62_RS17030 ENOG4105CEY Amp-dependent synthetase and ligase H0S62_RS17065 ENOG4105CHR reductase H0S62_RS17075 ENOG4105FUY alpha subunit H0S62_RS17095 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) H0S62_RS17105 ENOG4105DNH Major Facilitator H0S62_RS17130 ENOG4105C1G acyl-Coa dehydrogenase H0S62_RS17135 ENOG4108PTX LysR family Transcriptional regulator H0S62_RS17140 ENOG4107HP6 Transcriptional regulator H0S62_RS17155 ENOG4105MD1 YeeE YedE family protein H0S62_RS17170 ENOG4105DZG Dehydrogenase H0S62_RS17175 ENOG4105TW1 Carbohydrate-selective porin OprB H0S62_RS17180 ENOG4106JPM 3-dehydroshikimate dehydratase H0S62_RS17185 ENOG4105FF2 Type I DHQase H0S62_RS17190 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha H0S62_RS17195 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta H0S62_RS17200 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase H0S62_RS17205 ENOG4105D2S major facilitator superfamily H0S62_RS17210 ENOG4105F2Z 3-oxoadipate enol-lactonase H0S62_RS17215 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase H0S62_RS17220 ENOG4105CHU acetyl-coa acetyltransferase H0S62_RS17225 ENOG4107QNJ CoA-transferase subunit B H0S62_RS17230 ENOG4107QP7 CoA-transferase subunit A H0S62_RS17240 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) H0S62_RS17250 ENOG4107VMU Membrane H0S62_RS17295 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H0S62_RS17310 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) H0S62_RS17320 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H0S62_RS17325 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) H0S62_RS17365 ENOG4105C7B Threonine dehydratase H0S62_RS17375 ENOG4105CZN Potassium uptake protein H0S62_RS17380 ENOG4105HDD phospholipase H0S62_RS17390 ENOG4105E0K tonB-dependent siderophore receptor H0S62_RS17405 ENOG4105PV3 Inner membrane protein yqiJ H0S62_RS17415 ENOG4105C4M (Ubiquinol oxidase) subunit I H0S62_RS17420 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii H0S62_RS17440 ENOG41068P6 UPF0319 protein H0S62_RS17450 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) H0S62_RS17475 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) H0S62_RS17480 ENOG4105C8Y Acetylornithine aminotransferase H0S62_RS17485 ENOG4105M2J Glutaredoxin H0S62_RS17495 ENOG4105CC0 LysR family Transcriptional regulator H0S62_RS17500 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) H0S62_RS17505 ENOG4105CWM branched-chain amino acid transport system II carrier protein H0S62_RS17530 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) H0S62_RS17535 ENOG4105DE4 1-phosphofructokinase H0S62_RS17540 ENOG4105DM4 PTS System H0S62_RS17565 ENOG4105D5G Transposase H0S62_RS17570 ENOG4105CHH sulfate transporter H0S62_RS17590 ENOG4105C85 amino acid H0S62_RS17600 ENOG4105F7P transcriptional regulator AsnC family H0S62_RS17625 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 H0S62_RS17630 ENOG4105VEJ Heat shock protein H0S62_RS17640 ENOG4105Y3E Modulates RecA activity (By similarity) H0S62_RS17655 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H0S62_RS17675 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane H0S62_RS17680 ENOG4105DZP Membrane-associated zinc metalloprotease H0S62_RS17690 ENOG4105KNE Phosphatidate cytidylyltransferase H0S62_RS17695 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) H0S62_RS17720 ENOG4105CUX Signal transduction histidine kinase H0S62_RS17725 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H0S62_RS17790 ENOG4105CMR udp-glucose 4-epimerase H0S62_RS17795 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) H0S62_RS17815 ENOG4105T38 integral membrane protein H0S62_RS17820 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H0S62_RS17830 ENOG4105CVM Molybdenum cofactor synthesis domain protein H0S62_RS17835 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) H0S62_RS17850 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) H0S62_RS17870 ENOG4108IFG nitrite reductase, (NAD(P)H) H0S62_RS17875 ENOG4107QZF nitrite reductase NADPH large subunit H0S62_RS17885 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H0S62_RS17915 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) H0S62_RS17925 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein H0S62_RS17930 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase H0S62_RS17940 ENOG4105D8G Major Facilitator superfamily H0S62_RS17970 ENOG4105CBC glutamate synthase H0S62_RS18000 ENOG4105C0A alcohol dehydrogenase H0S62_RS18010 ENOG4105HSS phospholipase C H0S62_RS18015 ENOG4107QMP dna polymerase iii subunits gamma and tau H0S62_RS18040 ENOG4105CHR reductase H0S62_RS18045 ENOG4105CHU acetyl-coa acetyltransferase H0S62_RS18055 ENOG4105C5Q Transcriptional regulator H0S62_RS18065 ENOG4108NIW Leucine export protein LeuE H0S62_RS18070 ENOG4105EW9 transcriptional regulator AsnC family H0S62_RS18075 ENOG4105DKK Benzoate H0S62_RS18110 ENOG41081QV Universal stress protein H0S62_RS18115 ENOG4105C5H ABC transporter H0S62_RS18135 ENOG4105CNM Receptor H0S62_RS18150 ENOG4105D5G Transposase H0S62_RS18175 ENOG4105CUY Mechanosensitive ion channel H0S62_RS18190 ENOG4105R8C Transcriptional regulator H0S62_RS18205 ENOG4105EW9 transcriptional regulator AsnC family H0S62_RS18210 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) H0S62_RS18230 ENOG4105CD8 aminopeptidase N H0S62_RS18250 ENOG4105F4I Transcriptional regulator H0S62_RS18260 ENOG4107QUV Domain protein H0S62_RS18265 ENOG4105C0A alcohol dehydrogenase H0S62_RS18275 ENOG4107RR1 TRANSCRIPTIONal H0S62_RS18285 ENOG4107R55 ethanolamine transporter H0S62_RS18290 ENOG4105CPD ethanolamine ammonia-lyase H0S62_RS18295 ENOG4107FQ9 ethanolamine ammonia-lyase H0S62_RS18300 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) H0S62_RS18305 ENOG4105CX6 glutaminyL-tRNA synthetase H0S62_RS18315 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) H0S62_RS18325 ENOG4108RCM Nitroreductase H0S62_RS18330 ENOG4108TZV Membrane H0S62_RS18335 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) H0S62_RS18345 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) H0S62_RS18350 ENOG4105K8N protein family UPF0079, ATPase H0S62_RS18385 ENOG4105DZ2 Transcriptional regulator H0S62_RS18400 ENOG4105F27 Major Facilitator H0S62_RS18405 ENOG4105EYW Ion transport protein H0S62_RS18420 ENOG4107QIJ Aconitate hydratase 2 H0S62_RS18435 ENOG4105CFU surface antigen H0S62_RS18440 ENOG4107S74 Lysophospholipid transporter LplT H0S62_RS18455 ENOG4105CFQ glutamine synthetase H0S62_RS18460 ENOG4105EEX Two component transcriptional regulator (Winged helix family H0S62_RS18465 ENOG4105C08 Histidine kinase H0S62_RS18475 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) H0S62_RS18480 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) H0S62_RS18500 ENOG4105D06 uba thif-type nad fad binding protein H0S62_RS18505 ENOG4108MEJ flavin reductase domain protein H0S62_RS18515 ENOG4105C1G acyl-Coa dehydrogenase H0S62_RS18530 ENOG4105GVF (ABC) transporter H0S62_RS18535 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component H0S62_RS18540 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) H0S62_RS18550 ENOG4105D5G Transposase H0S62_RS18580 ENOG4105E2S oxidase) subunit II H0S62_RS18585 ENOG4105BZ9 Cytochrome C oxidase, subunit I H0S62_RS18590 ENOG4105CCU oxidase (Subunit III) H0S62_RS18595 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) H0S62_RS18620 ENOG4105CDU Replicative dna helicase H0S62_RS18625 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) H0S62_RS18675 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) H0S62_RS18680 ENOG4105DC1 bifunctional purine biosynthesis protein purh H0S62_RS18685 ENOG4105C12 Phosphoribosylglycinamide synthetase H0S62_RS18695 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) H0S62_RS18700 ENOG4108UMI ABC transporter, permease H0S62_RS18705 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) H0S62_RS18715 ENOG4105CK2 sodium dicarboxylate symporter H0S62_RS18760 ENOG4105DY2 Paraquat-inducible protein b H0S62_RS18765 ENOG4105F1S paraquat-inducible protein a H0S62_RS18795 ENOG4105CSH Transporter H0S62_RS18880 ENOG4105JXH GntR family transcriptional regulator H0S62_RS18890 ENOG4105D6U Sodium Glutamate Symporter H0S62_RS18980 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) H0S62_RS19000 ENOG4108JA2 transcriptioN-repair coupling factor H0S62_RS19100 ENOG4107TPY serine threonine protein kinase H0S62_RS19105 ENOG4105TMB Formate nitrite transporter H0S62_RS19110 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) H0S62_RS19170 ENOG4107RZZ dna polymerase iii epsilon subunit H0S62_RS19205 ENOG4108BUD transposase H0S62_RS19260 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H0S62_RS19330 ENOG4105C0B DNA polymerase III (alpha subunit) H0S62_RS19340 ENOG4106J5W DNA polymerase III (alpha subunit) H0S62_RS19385 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H0S62_RS19445 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) H0S62_RS19570 ENOG4105BZU Histidine kinase H0S62_RS19660 ENOG4105MZG transcriptional modulator of maze toxin, mazf H0S62_RS19665 ENOG41087RY SpoVT_AbrB