locus-tag class description E4K02_RS00105 ENOG4105XB7 anti-repressor protein E4K02_RS00225 ENOG4105DFP Integrase E4K02_RS00235 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding E4K02_RS00255 ENOG4105EJC lysr family transcriptional regulator E4K02_RS00260 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) E4K02_RS00275 ENOG4105DVW rieske (2Fe-2S) E4K02_RS00280 ENOG4105C26 Dehydrogenase E4K02_RS00285 ENOG4105E3J oxidoreductase E4K02_RS00300 ENOG4105C4K Nad synthetase E4K02_RS00310 ENOG4105EUB pirin domain protein E4K02_RS00315 ENOG4108YXA Membrane E4K02_RS00360 ENOG4105KEG ribosomal-protein-alanine acetyltransferase E4K02_RS00370 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) E4K02_RS00375 ENOG4105C3M thioredoxin reductase E4K02_RS00380 ENOG4105CNU cell division protein FtsK E4K02_RS00385 ENOG4105CCF Lysine exporter protein (Lyse ygga) E4K02_RS00400 ENOG4107QMS site-determining protein E4K02_RS00415 ENOG4106HNH Acyl-transferase E4K02_RS00420 ENOG4108ZG0 Ompa motb domain protein E4K02_RS00425 ENOG4105C4R Atp-dependent dna helicase E4K02_RS00435 ENOG4107QKV phosphomannomutase E4K02_RS00455 ENOG4105F9F transposase E4K02_RS00470 ENOG4105F9F transposase E4K02_RS00500 ENOG41090R7 Ferric uptake E4K02_RS00505 ENOG4105CZX twitching motility protein E4K02_RS00510 ENOG4105CZX twitching motility protein E4K02_RS00515 ENOG4105DFA alanine racemase domain protein E4K02_RS00520 ENOG4105EYH Exonuclease E4K02_RS00525 ENOG4107RH8 nuclease SbcCD subunit D E4K02_RS00545 ENOG4105ECP epimerase E4K02_RS00550 ENOG4105MWK D-amino acid dehydrogenase, small subunit E4K02_RS00555 ENOG4105D52 delta-aminolevulinic acid dehydratase E4K02_RS00560 ENOG4108VUY thioesterase Superfamily protein E4K02_RS00565 ENOG4105CW7 secretion protein, HlyD family E4K02_RS00570 ENOG4105C0R drug resistance transporter emrb qaca subfamily E4K02_RS00575 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) E4K02_RS00635 ENOG4105C54 Major Facilitator superfamily E4K02_RS00640 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) E4K02_RS00665 ENOG4105D5Q Arginine ornithine antiporter E4K02_RS00670 ENOG4107QK5 Homocysteine s-methyltransferase E4K02_RS00695 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) E4K02_RS00700 ENOG4105C94 Transporter E4K02_RS00705 ENOG4105C94 Transporter E4K02_RS00715 ENOG4108S4H thioesterase Superfamily protein E4K02_RS00725 ENOG4105CKI cobalamin synthesis protein E4K02_RS00735 ENOG4108VWS Yaeq family E4K02_RS00745 ENOG4107BJW polysaccharide deacetylase E4K02_RS00750 ENOG4105CND Glycosyl transferase, family 2 E4K02_RS00760 ENOG4106YT9 Enoyl-CoA hydratase E4K02_RS00775 ENOG41069M3 Transcriptional regulator E4K02_RS00795 ENOG4105CHR reductase E4K02_RS00805 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase E4K02_RS00810 ENOG4105DJB Major Facilitator Superfamily E4K02_RS00820 ENOG4108MXF Alpha Beta Hydrolase E4K02_RS00825 ENOG4105CHR reductase E4K02_RS00840 ENOG4105C7K acetolactate synthase E4K02_RS00850 ENOG4105CSH Transporter E4K02_RS00855 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) E4K02_RS00860 ENOG4105CSV Glutaminase E4K02_RS00865 ENOG4108R6W Transcriptional regulator, ARAC family E4K02_RS00870 ENOG4105EU0 Major facilitator Superfamily E4K02_RS00880 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) E4K02_RS00895 ENOG4108PZW LysR family Transcriptional regulator E4K02_RS00905 ENOG4105CSP Major Facilitator Superfamily E4K02_RS00920 ENOG4105C3R Methionine synthase E4K02_RS00925 ENOG4105CJ3 phosphate transporter E4K02_RS00945 ENOG4105E6M Sulphatase-modifying factor protein E4K02_RS00950 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) E4K02_RS00965 ENOG4107RNH Outer membrane receptor FepA E4K02_RS00985 ENOG4108UJV acyl-CoA thioesterase i E4K02_RS00990 ENOG4108I0Y (ABC) transporter E4K02_RS00995 ENOG4105CV6 ABC transporter, permease E4K02_RS01000 ENOG4107U91 Rhomboid family E4K02_RS01025 ENOG4105C5Q Transcriptional regulator E4K02_RS01035 ENOG4107QZF nitrite reductase NADPH large subunit E4K02_RS01040 ENOG4105VCQ rubredoxin E4K02_RS01060 ENOG4108MRJ E4K02_RS01075 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) E4K02_RS01090 ENOG4105D4T Citrate transporter E4K02_RS01095 ENOG4105F9F transposase E4K02_RS01105 ENOG4105C37 (CBS) domain E4K02_RS01115 ENOG4107RET Isocitrate lyase E4K02_RS01145 ENOG4105CQM Urea amidohydrolase subunit alpha E4K02_RS01155 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) E4K02_RS01170 ENOG4106H78 methyltransferase E4K02_RS01175 ENOG4105CJN penicillin-binding protein E4K02_RS01200 ENOG4105CSM endonuclease III E4K02_RS01205 ENOG4108R3D Electron transport complex E4K02_RS01210 ENOG4105D82 Glutamate dehydrogenase E4K02_RS01220 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b E4K02_RS01255 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase E4K02_RS01445 ENOG4105UPP uncharacterized protein ydcA E4K02_RS01530 ENOG4105DIJ Phosphoethanolamine transferase E4K02_RS01560 ENOG4107RAQ aminopeptidase E4K02_RS01565 ENOG4105D0A hydroxylase E4K02_RS01570 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family E4K02_RS01590 ENOG4108ZUB Lysine exporter protein (Lyse ygga) E4K02_RS01595 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) E4K02_RS01605 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) E4K02_RS01620 ENOG4105W4M Transport-associated protein E4K02_RS01630 ENOG4105E09 nadh pyrophosphatase E4K02_RS01650 ENOG4107RZZ dna polymerase iii epsilon subunit E4K02_RS01655 ENOG4105E9H Lytic Murein transglycosylase E4K02_RS01655 ENOG4105E9H Lytic Murein transglycosylase E4K02_RS01665 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component E4K02_RS01670 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component E4K02_RS01675 ENOG4108JQ5 ABC transporter E4K02_RS01695 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) E4K02_RS01715 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E4K02_RS01725 ENOG4105D01 (LipO)protein E4K02_RS01755 ENOG4106B0W Curli production assembly transport component CsgG E4K02_RS01765 ENOG4107Y60 (LipO)protein E4K02_RS01775 ENOG4105C85 amino acid E4K02_RS01795 ENOG4105C1G acyl-Coa dehydrogenase E4K02_RS01810 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase E4K02_RS01815 ENOG4108SC4 )-transporter E4K02_RS01830 ENOG4105E3J oxidoreductase E4K02_RS01840 ENOG4105D2S major facilitator superfamily E4K02_RS01845 ENOG4105EPF Outer membrane porin E4K02_RS01865 ENOG4107RN6 Monooxygenase E4K02_RS01875 ENOG4105JQZ Methyltransferase E4K02_RS01880 ENOG4105F95 Monooxygenase E4K02_RS01925 ENOG4105F95 Monooxygenase E4K02_RS01935 ENOG4105C7N Xanthine uracil vitamin C permease E4K02_RS01940 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) E4K02_RS01955 ENOG4105CPW cytochrome b561 E4K02_RS01965 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) E4K02_RS01975 ENOG4105CFH Aspartokinase E4K02_RS01985 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase E4K02_RS02000 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis E4K02_RS02015 ENOG4105CPC Aldo Keto reductase E4K02_RS02020 ENOG4107RYR Transcriptional regulator, Crp Fnr family E4K02_RS02025 ENOG4108UKZ OsmC family E4K02_RS02040 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E4K02_RS02070 ENOG4105CD3 dihydroorotase E4K02_RS02075 ENOG4108ZG0 Ompa motb domain protein E4K02_RS02085 ENOG4108TGY Glutathione S-transferase E4K02_RS02090 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) E4K02_RS02100 ENOG4108K3A Glutathione S-transferase E4K02_RS02110 ENOG4108JU3 Alkyl hydroperoxide reductase E4K02_RS02120 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) E4K02_RS02130 ENOG4105D3R alkyl hydroperoxide reductase E4K02_RS02135 ENOG4105CQ7 ATP-dependent helicase E4K02_RS02150 ENOG4105D2S major facilitator superfamily E4K02_RS02155 ENOG4105DKK Benzoate E4K02_RS02160 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase E4K02_RS02165 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein E4K02_RS02170 ENOG4108UKV benzoate 1,2-dioxygenase E4K02_RS02175 ENOG4105FUY alpha subunit E4K02_RS02180 ENOG4108KB2 LysR family Transcriptional regulator E4K02_RS02240 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) E4K02_RS02275 ENOG410829K Lysine exporter protein (Lyse ygga) E4K02_RS02280 ENOG4105VEQ Cold shock protein E4K02_RS02295 ENOG4105F9F transposase E4K02_RS02320 ENOG4105F9F transposase E4K02_RS02360 ENOG4105F9F transposase E4K02_RS02400 ENOG4105C2X Arabinose 5-phosphate isomerase E4K02_RS02415 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA E4K02_RS02420 ENOG4108IUZ ABC transporter E4K02_RS02425 ENOG4105DFG type I secretion outer membrane protein E4K02_RS02465 ENOG4108Z4U Ferredoxin E4K02_RS02485 ENOG4107AQZ Membrane E4K02_RS02490 ENOG4105BZU Histidine kinase E4K02_RS02495 ENOG4105D1S lipid A biosynthesis E4K02_RS02510 ENOG4105D2S major facilitator superfamily E4K02_RS02530 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) E4K02_RS02560 ENOG4105F9F transposase E4K02_RS02565 ENOG4108WAV Transcriptional regulator E4K02_RS02570 ENOG4105C5A transporter E4K02_RS02590 ENOG4108JIK carboxylase E4K02_RS02595 ENOG4107R4J Chloride channel E4K02_RS02610 ENOG4105R8C Transcriptional regulator E4K02_RS02620 ENOG4105E2A Dehydrogenase E4K02_RS02635 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase E4K02_RS02640 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF E4K02_RS02655 ENOG4105MRR Transcriptional regulator (By similarity) E4K02_RS02700 ENOG4105EMY transcriptional regulator E4K02_RS02710 ENOG4107Y2X deaminase E4K02_RS02725 ENOG4105F9F transposase E4K02_RS02740 ENOG4105WPN DNA integration recombination invertion protein E4K02_RS02745 ENOG4105F9F transposase E4K02_RS02755 ENOG4108Z4X TRANSCRIPTIONal E4K02_RS02770 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) E4K02_RS02790 ENOG4105MWK D-amino acid dehydrogenase, small subunit E4K02_RS02815 ENOG4105CZJ Aldehyde dehydrogenase E4K02_RS02820 ENOG4107QTZ amino acid E4K02_RS02825 ENOG4105EJQ L-serine dehydratase E4K02_RS02830 ENOG4105DXM phenylacetic acid degradation protein E4K02_RS02835 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit E4K02_RS02840 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit E4K02_RS02845 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit E4K02_RS02850 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit E4K02_RS02855 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) E4K02_RS02860 ENOG4105E39 Enoyl-CoA hydratase E4K02_RS02865 ENOG4108UKI Enoyl-CoA hydratase E4K02_RS02870 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase E4K02_RS02875 ENOG4105CHU acetyl-coa acetyltransferase E4K02_RS02880 ENOG4105DZS Phenylacetate-CoA ligase E4K02_RS02885 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein E4K02_RS02890 ENOG4108Z0R Transferase E4K02_RS02895 ENOG4107YAU phenylacetic acid degradation protein E4K02_RS02950 ENOG4107VGR Catalase E4K02_RS02955 ENOG4105CPW cytochrome b561 E4K02_RS02975 ENOG4108MXF Alpha Beta Hydrolase E4K02_RS02980 ENOG4105MXW flavin reductase domain protein, FMN-binding E4K02_RS02985 ENOG4108M8W Monooxygenase E4K02_RS02990 ENOG4105C26 Dehydrogenase E4K02_RS03000 ENOG4105ETS cytosine purines uracil thiamine allantoin E4K02_RS03010 ENOG4105C26 Dehydrogenase E4K02_RS03015 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase E4K02_RS03020 ENOG4105HEI LysR family (Transcriptional regulator E4K02_RS03030 ENOG4107HP6 Transcriptional regulator E4K02_RS03040 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase E4K02_RS03055 ENOG4105C4Y ABC transporter E4K02_RS03060 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) E4K02_RS03065 ENOG4107RCV ABC transporter, permease E4K02_RS03075 ENOG4107STF Involved in phosphonate degradation (By similarity) E4K02_RS03080 ENOG4108KAZ Involved in phosphonate degradation (By similarity) E4K02_RS03085 ENOG4107RGD Major Facilitator superfamily E4K02_RS03090 ENOG4105C1G acyl-Coa dehydrogenase E4K02_RS03105 ENOG4108UKI Enoyl-CoA hydratase E4K02_RS03115 ENOG4105EQ0 Major Facilitator superfamily E4K02_RS03125 ENOG4105CHU acetyl-coa acetyltransferase E4K02_RS03130 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase E4K02_RS03135 ENOG4105CHR reductase E4K02_RS03140 ENOG4105E39 Enoyl-CoA hydratase E4K02_RS03145 ENOG4105C1G acyl-Coa dehydrogenase E4K02_RS03150 ENOG4107RGD Major Facilitator superfamily E4K02_RS03155 ENOG4107QP7 CoA-transferase subunit A E4K02_RS03160 ENOG4107QNJ CoA-transferase subunit B E4K02_RS03180 ENOG4105CSU acyl-Coa dehydrogenase E4K02_RS03195 ENOG4105CC0 LysR family Transcriptional regulator E4K02_RS03210 ENOG4105E39 Enoyl-CoA hydratase E4K02_RS03215 ENOG4107QX3 carboxylase E4K02_RS03220 ENOG4105C1G acyl-Coa dehydrogenase E4K02_RS03225 ENOG4105R8C Transcriptional regulator E4K02_RS03230 ENOG4105CEY Amp-dependent synthetase and ligase E4K02_RS03240 ENOG4105F9F transposase E4K02_RS03265 ENOG4105HEI LysR family (Transcriptional regulator E4K02_RS03280 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) E4K02_RS03330 ENOG4105F9F transposase E4K02_RS03350 ENOG4105CYX Short-chain dehydrogenase reductase Sdr E4K02_RS03375 ENOG4105KT5 UmuD protein E4K02_RS03385 ENOG4105EW9 transcriptional regulator AsnC family E4K02_RS03395 ENOG4105BZU Histidine kinase E4K02_RS03400 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase E4K02_RS03415 ENOG4105EAD ABC transporter E4K02_RS03420 ENOG4108HW4 amino acid AbC transporter E4K02_RS03430 ENOG4107RP9 extracellular solute-binding protein, family 3 E4K02_RS03435 ENOG4105CT1 (ABC) transporter E4K02_RS03445 ENOG4105EXG Transcriptional regulator E4K02_RS03455 ENOG4105C9B Cysteine desulfurase E4K02_RS03460 ENOG4105ESN nucleotide-binding protein E4K02_RS03465 ENOG4105D7W serine acetyltransferase E4K02_RS03475 ENOG4105CHR reductase E4K02_RS03480 ENOG4105CBN LysR family transcriptional regulator E4K02_RS03485 ENOG4105CYM Glutathione S-transferase E4K02_RS03490 ENOG4108SHQ Glutathione S-transferase E4K02_RS03495 ENOG4105CMU LysR family (Transcriptional regulator E4K02_RS03500 ENOG4105VAW lrga family E4K02_RS03505 ENOG41067MG lrgb family E4K02_RS03525 ENOG4105DXI Major Facilitator superfamily E4K02_RS03535 ENOG4105ETT transcriptional Regulator, LysR family E4K02_RS03545 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase E4K02_RS03550 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) E4K02_RS03565 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase E4K02_RS03570 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase E4K02_RS03585 ENOG4108K70 Transcriptional regulator E4K02_RS03590 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E4K02_RS03600 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E4K02_RS03605 ENOG4105C4M (Ubiquinol oxidase) subunit I E4K02_RS03630 ENOG4105F9F transposase E4K02_RS03635 ENOG4105C54 Major Facilitator superfamily E4K02_RS03645 ENOG4105F9F transposase E4K02_RS03655 ENOG4106FTQ Taurine ABC transporter, periplasmic E4K02_RS03660 ENOG4108IY8 ABC, transporter E4K02_RS03665 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component E4K02_RS03680 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease E4K02_RS03695 ENOG4105F9F transposase E4K02_RS03710 ENOG4105CPN adenine deaminase E4K02_RS03725 ENOG41082YX Transcriptional regulator, arsr family E4K02_RS03730 ENOG4105D6J arsenicaL-resistance protein E4K02_RS03735 ENOG4108KB2 LysR family Transcriptional regulator E4K02_RS03750 ENOG4108JU3 Alkyl hydroperoxide reductase E4K02_RS03775 ENOG4105C0B DNA polymerase III (alpha subunit) E4K02_RS03795 ENOG4105CHM Aminotransferase E4K02_RS03805 ENOG4108V06 Glutathione peroxidase E4K02_RS03810 ENOG4105E7U AraC family transcriptional regulator E4K02_RS03840 ENOG4105ZED uncharacterized protein ygaH E4K02_RS03845 ENOG4108UMN azlc family E4K02_RS03870 ENOG4105C3G gtp-binding protein E4K02_RS03875 ENOG4108UMI ABC transporter, permease E4K02_RS03880 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) E4K02_RS03885 ENOG4105D01 (LipO)protein E4K02_RS03890 ENOG4105D01 (LipO)protein E4K02_RS03905 ENOG4107T8P acyl-Coa dehydrogenase E4K02_RS03920 ENOG4105EAD ABC transporter E4K02_RS03925 ENOG4105DRP amino acid AbC transporter E4K02_RS03930 ENOG4105CDA abc transporter atp-binding protein E4K02_RS03945 ENOG4105EW9 transcriptional regulator AsnC family E4K02_RS03965 ENOG4105F9F transposase E4K02_RS04010 ENOG4105CC0 LysR family Transcriptional regulator E4K02_RS04020 ENOG4105ETS cytosine purines uracil thiamine allantoin E4K02_RS04030 ENOG4108IPJ Membrane E4K02_RS04080 ENOG4105X0I Fimbrial E4K02_RS04100 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) E4K02_RS04105 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) E4K02_RS04125 ENOG4108HWY Beta-lactamase E4K02_RS04130 ENOG4105F9F transposase E4K02_RS04155 ENOG4105CV1 Transketolase (EC 2.2.1.1) E4K02_RS04165 ENOG4108YYC ycei family E4K02_RS04185 ENOG4108T58 Mg2 transport protein CorA E4K02_RS04200 ENOG4105YGK Pfam:UPF0157 E4K02_RS04205 ENOG4105C26 Dehydrogenase E4K02_RS04210 ENOG4105EW9 transcriptional regulator AsnC family E4K02_RS04215 ENOG4105CK7 Sodium proline symporter E4K02_RS04220 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) E4K02_RS04230 ENOG4108ZX5 transcriptional regulator E4K02_RS04240 ENOG4105BZ1 (ABC) transporter E4K02_RS04245 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme E4K02_RS04250 ENOG4105XPP Protein of unknown function (DUF1275) E4K02_RS04260 ENOG41080HT Transcriptional regulator, arsr family E4K02_RS04270 ENOG4105EZE Cupin 4 family protein E4K02_RS04275 ENOG4108UHJ MAF-like protein E4K02_RS04295 ENOG4105D2N Aldolase E4K02_RS04300 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) E4K02_RS04305 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) E4K02_RS04310 ENOG4105EHM Aminoglycoside phosphotransferase E4K02_RS04315 ENOG4108S0S Nucleotidyl transferase E4K02_RS04325 ENOG4107QJE Chromosome Partitioning Protein E4K02_RS04330 ENOG4105FA0 parb-like partition protein E4K02_RS04345 ENOG4105BZ1 (ABC) transporter E4K02_RS04350 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) E4K02_RS04360 ENOG4107QRG dna polymerase iii E4K02_RS04370 ENOG4105F8V Hydrolase, tatD family E4K02_RS04395 ENOG4108RTD type II secretion system protein K E4K02_RS04415 ENOG4108Z6B deaminase E4K02_RS04430 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) E4K02_RS04435 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) E4K02_RS04455 ENOG4107RN6 Monooxygenase E4K02_RS04465 ENOG4105D6Z AFG1 family ATPase E4K02_RS04470 ENOG4107QP3 malate synthase g E4K02_RS04480 ENOG4105SG9 biopolymer transport protein, ExbD E4K02_RS04495 ENOG4108DNJ Pfam:TonB E4K02_RS04505 ENOG4105F9F transposase E4K02_RS04520 ENOG4105DGW oligopeptidase A E4K02_RS04530 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E4K02_RS04550 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase E4K02_RS04565 ENOG4105K4T epimerase E4K02_RS04570 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) E4K02_RS04590 ENOG4108JA2 transcriptioN-repair coupling factor E4K02_RS04600 ENOG4105F8J Adenylate Guanylate cyclase E4K02_RS04605 ENOG4108ZIT Ferredoxin, 2FE-2S E4K02_RS04620 ENOG4108Z4V iron-sulfur cluster assembly E4K02_RS04625 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins E4K02_RS04635 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family E4K02_RS04650 ENOG4105K70 DNA-binding protein E4K02_RS04655 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) E4K02_RS04660 ENOG4105E7U AraC family transcriptional regulator E4K02_RS04665 ENOG4105EEF Alkane 1-monooxygenase E4K02_RS04670 ENOG4105C1G acyl-Coa dehydrogenase E4K02_RS04675 ENOG4105C1G acyl-Coa dehydrogenase E4K02_RS04690 ENOG4108Z66 YbaK ebsC protein E4K02_RS04710 ENOG4105DUU IucA IucC family protein E4K02_RS04715 ENOG4105DJU Siderophore biosynthesis protein E4K02_RS04725 ENOG4105JSC dimethylmenaquinone methyltransferase E4K02_RS04765 ENOG4108YZT Adenosylcobinamide kinase E4K02_RS04770 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) E4K02_RS04790 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E4K02_RS04795 ENOG4107TSN permease E4K02_RS04815 ENOG4105CNM Receptor E4K02_RS04820 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) E4K02_RS04835 ENOG4105CJ1 ABC, transporter E4K02_RS04840 ENOG4107QWP ABC-2 type transporter E4K02_RS04845 ENOG4107QWP ABC-2 type transporter E4K02_RS04870 ENOG4105K59 histidine triad (HIT) protein E4K02_RS04885 ENOG4105F9F transposase E4K02_RS04915 ENOG4105F2W methyltransferase E4K02_RS04925 ENOG4105C28 cystathionine E4K02_RS04940 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) E4K02_RS04985 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) E4K02_RS04990 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) E4K02_RS05000 ENOG4105BZU Histidine kinase E4K02_RS05015 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) E4K02_RS05020 ENOG4105F9F transposase E4K02_RS05030 ENOG4107R0V Pyruvate dehydrogenase E4K02_RS05035 ENOG4105CPP Dehydrogenase, E1 component E4K02_RS05050 ENOG4105CHR reductase E4K02_RS05060 ENOG4105FFC UPF0187 protein E4K02_RS05070 ENOG4107QPB Beta-lactamase domain protein E4K02_RS05080 ENOG4108VCT Sulfite exporter TauE/SafE E4K02_RS05095 ENOG4105UEI Transcriptional Regulator AraC Family E4K02_RS05100 ENOG4105KVH Transcriptional regulator E4K02_RS05105 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) E4K02_RS05120 ENOG4105CBX hi0933 family E4K02_RS05130 ENOG4106FTQ Taurine ABC transporter, periplasmic E4K02_RS05135 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component E4K02_RS05155 ENOG4105CSH Transporter E4K02_RS05165 ENOG4108IJ0 Aspartate ammonia-lyase E4K02_RS05180 ENOG4107YNJ LysR family Transcriptional regulator E4K02_RS05190 ENOG4105CHU acetyl-coa acetyltransferase E4K02_RS05195 ENOG4105CRW Short chain fatty acid transporter E4K02_RS05210 ENOG4108M0I Transcriptional regulator E4K02_RS05220 ENOG4105CY2 Citrate transporter E4K02_RS05225 ENOG4105DTD Dehydrogenase E4K02_RS05230 ENOG4105CF7 AraC family transcriptional regulator E4K02_RS05235 ENOG4105D2S major facilitator superfamily E4K02_RS05245 ENOG4105CHR reductase E4K02_RS05270 ENOG4105F57 Anthranilate dioxygenase reductase E4K02_RS05275 ENOG4108YS2 small subunit E4K02_RS05280 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit E4K02_RS05285 ENOG4105F4R Transcriptional regulator mode E4K02_RS05290 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein E4K02_RS05295 ENOG4105E0C molybdate abc transporter E4K02_RS05300 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) E4K02_RS05305 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase E4K02_RS05310 ENOG4105WQI isochorismatase E4K02_RS05315 ENOG4105F9F transposase E4K02_RS05325 ENOG4107T31 5'-nucleotidase E4K02_RS05360 ENOG4108IGT Dipeptidase E4K02_RS05380 ENOG4107RZC phospholipase d E4K02_RS05440 ENOG4105X0I Fimbrial E4K02_RS05485 ENOG4105CEY Amp-dependent synthetase and ligase E4K02_RS05495 ENOG4105CSU acyl-Coa dehydrogenase E4K02_RS05505 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr E4K02_RS05510 ENOG41061TZ Short-chain dehydrogenase reductase Sdr E4K02_RS05515 ENOG41061TZ Short-chain dehydrogenase reductase Sdr E4K02_RS05520 ENOG4108PTX LysR family Transcriptional regulator E4K02_RS05525 ENOG4107Z3H Transcriptional regulator, TetR family E4K02_RS05550 ENOG4108Z6Z Transcriptional regulator E4K02_RS05565 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E4K02_RS05580 ENOG4105CZJ Aldehyde dehydrogenase E4K02_RS05600 ENOG4107EJG GntR family transcriptional regulator E4K02_RS05610 ENOG4108KB2 LysR family Transcriptional regulator E4K02_RS05615 ENOG4105DTQ mandelate racemase muconate lactonizing E4K02_RS05620 ENOG4105NN7 muconolactone delta-isomerase E4K02_RS05630 ENOG4107QP7 CoA-transferase subunit A E4K02_RS05635 ENOG4107QNJ CoA-transferase subunit B E4K02_RS05640 ENOG4105CHU acetyl-coa acetyltransferase E4K02_RS05645 ENOG4105F2Z 3-oxoadipate enol-lactonase E4K02_RS05650 ENOG4105C26 Dehydrogenase E4K02_RS05660 ENOG4105F11 amine oxidase E4K02_RS05680 ENOG4105CHR reductase E4K02_RS05690 ENOG4105FUY alpha subunit E4K02_RS05710 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) E4K02_RS05720 ENOG4105DNH Major Facilitator E4K02_RS05760 ENOG4105C1G acyl-Coa dehydrogenase E4K02_RS05765 ENOG4108PTX LysR family Transcriptional regulator E4K02_RS05770 ENOG4107HP6 Transcriptional regulator E4K02_RS05785 ENOG4105MD1 YeeE YedE family protein E4K02_RS05795 ENOG4105DZG Dehydrogenase E4K02_RS05800 ENOG4105TW1 Carbohydrate-selective porin OprB E4K02_RS05805 ENOG4106JPM 3-dehydroshikimate dehydratase E4K02_RS05825 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha E4K02_RS05830 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta E4K02_RS05835 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase E4K02_RS05840 ENOG4105D2S major facilitator superfamily E4K02_RS05845 ENOG4105F2Z 3-oxoadipate enol-lactonase E4K02_RS05850 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase E4K02_RS05855 ENOG4105CHU acetyl-coa acetyltransferase E4K02_RS05860 ENOG4107QNJ CoA-transferase subunit B E4K02_RS05865 ENOG4107QP7 CoA-transferase subunit A E4K02_RS05875 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) E4K02_RS05880 ENOG4107VMU Membrane E4K02_RS05945 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E4K02_RS05960 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E4K02_RS05970 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E4K02_RS05975 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) E4K02_RS06005 ENOG4105C7B Threonine dehydratase E4K02_RS06015 ENOG4105CZN Potassium uptake protein E4K02_RS06020 ENOG4105HDD phospholipase E4K02_RS06030 ENOG4105E0K tonB-dependent siderophore receptor E4K02_RS06045 ENOG4105PV3 Inner membrane protein yqiJ E4K02_RS06060 ENOG4105C4M (Ubiquinol oxidase) subunit I E4K02_RS06065 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E4K02_RS06085 ENOG41068P6 UPF0319 protein E4K02_RS06095 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) E4K02_RS06125 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) E4K02_RS06130 ENOG4105C8Y Acetylornithine aminotransferase E4K02_RS06135 ENOG4105M2J Glutaredoxin E4K02_RS06145 ENOG4105CC0 LysR family Transcriptional regulator E4K02_RS06150 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) E4K02_RS06155 ENOG4105CWM branched-chain amino acid transport system II carrier protein E4K02_RS06180 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) E4K02_RS06185 ENOG4105DE4 1-phosphofructokinase E4K02_RS06190 ENOG4105DM4 PTS System E4K02_RS06225 ENOG4105D8V Glucose sorbosone dehydrogenase E4K02_RS06230 ENOG4108RAV Conserved protein E4K02_RS06235 ENOG4105CHH sulfate transporter E4K02_RS06250 ENOG4105C85 amino acid E4K02_RS06260 ENOG4105F7P transcriptional regulator AsnC family E4K02_RS06290 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 E4K02_RS06295 ENOG4105VEJ Heat shock protein E4K02_RS06305 ENOG4105Y3E Modulates RecA activity (By similarity) E4K02_RS06320 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) E4K02_RS06340 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane E4K02_RS06345 ENOG4105DZP Membrane-associated zinc metalloprotease E4K02_RS06355 ENOG4105KNE Phosphatidate cytidylyltransferase E4K02_RS06360 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) E4K02_RS06385 ENOG4105CUX Signal transduction histidine kinase E4K02_RS06390 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E4K02_RS06450 ENOG4105CMR udp-glucose 4-epimerase E4K02_RS06455 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) E4K02_RS06475 ENOG4105T38 integral membrane protein E4K02_RS06480 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E4K02_RS06490 ENOG4105CVM Molybdenum cofactor synthesis domain protein E4K02_RS06495 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) E4K02_RS06510 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) E4K02_RS06530 ENOG4108IFG nitrite reductase, (NAD(P)H) E4K02_RS06535 ENOG4107QZF nitrite reductase NADPH large subunit E4K02_RS06545 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E4K02_RS06570 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein E4K02_RS06575 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase E4K02_RS06585 ENOG4105D8G Major Facilitator superfamily E4K02_RS06600 ENOG4105F9F transposase E4K02_RS06610 ENOG4105F9F transposase E4K02_RS06890 ENOG4105F9F transposase E4K02_RS06905 ENOG4105CBC glutamate synthase E4K02_RS06930 ENOG4105F9F transposase E4K02_RS06940 ENOG4105C0A alcohol dehydrogenase E4K02_RS06950 ENOG4105HSS phospholipase C E4K02_RS06955 ENOG4107QMP dna polymerase iii subunits gamma and tau E4K02_RS06980 ENOG4105CHR reductase E4K02_RS06985 ENOG4105CHU acetyl-coa acetyltransferase E4K02_RS06995 ENOG4105F9F transposase E4K02_RS07005 ENOG4105C5Q Transcriptional regulator E4K02_RS07015 ENOG4108NIW Leucine export protein LeuE E4K02_RS07020 ENOG4105EW9 transcriptional regulator AsnC family E4K02_RS07025 ENOG4105DKK Benzoate E4K02_RS07035 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic E4K02_RS07050 ENOG41081QV Universal stress protein E4K02_RS07055 ENOG4105C5H ABC transporter E4K02_RS07060 ENOG4105F9F transposase E4K02_RS07080 ENOG4105CNM Receptor E4K02_RS07095 ENOG4105F9F transposase E4K02_RS07115 ENOG4105CUY Mechanosensitive ion channel E4K02_RS07125 ENOG4105R8C Transcriptional regulator E4K02_RS07135 ENOG4105F9F transposase E4K02_RS07140 ENOG4105EW9 transcriptional regulator AsnC family E4K02_RS07145 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) E4K02_RS07170 ENOG4108D1K outer membrane usher protein E4K02_RS07195 ENOG4105F9F transposase E4K02_RS07200 ENOG4105CD8 aminopeptidase N E4K02_RS07220 ENOG41086D8 Transcriptional regulator E4K02_RS07230 ENOG4107QUV Domain protein E4K02_RS07235 ENOG4105C0A alcohol dehydrogenase E4K02_RS07245 ENOG4107RR1 TRANSCRIPTIONal E4K02_RS07255 ENOG4107R55 ethanolamine transporter E4K02_RS07260 ENOG4105CPD ethanolamine ammonia-lyase E4K02_RS07265 ENOG4107FQ9 ethanolamine ammonia-lyase E4K02_RS07270 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) E4K02_RS07275 ENOG4105CX6 glutaminyL-tRNA synthetase E4K02_RS07295 ENOG4108RCM Nitroreductase E4K02_RS07300 ENOG4108TZV Membrane E4K02_RS07305 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) E4K02_RS07315 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) E4K02_RS07320 ENOG4105K8N protein family UPF0079, ATPase E4K02_RS07355 ENOG4105DZ2 Transcriptional regulator E4K02_RS07370 ENOG4105F27 Major Facilitator E4K02_RS07375 ENOG4105EYW Ion transport protein E4K02_RS07385 ENOG4107QIJ Aconitate hydratase 2 E4K02_RS07405 ENOG4105CFU surface antigen E4K02_RS07410 ENOG4107S74 Lysophospholipid transporter LplT E4K02_RS07425 ENOG4105CFQ glutamine synthetase E4K02_RS07430 ENOG4105EEX Two component transcriptional regulator (Winged helix family E4K02_RS07435 ENOG4105C08 Histidine kinase E4K02_RS07445 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) E4K02_RS07450 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) E4K02_RS07470 ENOG4105D06 uba thif-type nad fad binding protein E4K02_RS07475 ENOG4108MEJ flavin reductase domain protein E4K02_RS07485 ENOG4105C1G acyl-Coa dehydrogenase E4K02_RS07500 ENOG4105GVF (ABC) transporter E4K02_RS07505 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component E4K02_RS07510 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) E4K02_RS07525 ENOG4105CC0 LysR family Transcriptional regulator E4K02_RS07545 ENOG4105DEN Luciferase family E4K02_RS07560 ENOG4105CND Glycosyl transferase, family 2 E4K02_RS07565 ENOG4107BJW polysaccharide deacetylase E4K02_RS07590 ENOG4105E2S oxidase) subunit II E4K02_RS07595 ENOG4105BZ9 Cytochrome C oxidase, subunit I E4K02_RS07600 ENOG4105CCU oxidase (Subunit III) E4K02_RS07605 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) E4K02_RS07630 ENOG4105CDU Replicative dna helicase E4K02_RS07635 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) E4K02_RS07685 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) E4K02_RS07690 ENOG4105DC1 bifunctional purine biosynthesis protein purh E4K02_RS07695 ENOG4105C12 Phosphoribosylglycinamide synthetase E4K02_RS07705 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) E4K02_RS07710 ENOG4108UMI ABC transporter, permease E4K02_RS07715 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) E4K02_RS07725 ENOG4105CK2 sodium dicarboxylate symporter E4K02_RS07760 ENOG4105C3M thioredoxin reductase E4K02_RS07775 ENOG4105DY2 Paraquat-inducible protein b E4K02_RS07780 ENOG4105F1S paraquat-inducible protein a E4K02_RS07805 ENOG4105CSH Transporter E4K02_RS07835 ENOG4105F9F transposase E4K02_RS07865 ENOG4105JXH GntR family transcriptional regulator E4K02_RS07875 ENOG4105D6U Sodium Glutamate Symporter E4K02_RS07915 ENOG4105H4F exported protein E4K02_RS07950 ENOG4105C26 Dehydrogenase E4K02_RS07955 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) E4K02_RS07960 ENOG4105EVZ LysR family transcriptional regulator E4K02_RS07985 ENOG4105D9P serine threonine protein kinase E4K02_RS08015 ENOG4105KTH gatB Yqey E4K02_RS08020 ENOG4105ERG peptidase m48, ste24p E4K02_RS08025 ENOG4105C5I Dehydrogenase E4K02_RS08040 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase E4K02_RS08075 ENOG41069NU Nitroreductase E4K02_RS08085 ENOG4105C1J atp-dependent rna helicase E4K02_RS08090 ENOG4105VEQ Cold shock protein E4K02_RS08100 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E4K02_RS08105 ENOG4105M08 Membrane E4K02_RS08135 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) E4K02_RS08140 ENOG4105CIN aminoacyl-histidine dipeptidase E4K02_RS08150 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase E4K02_RS08155 ENOG4105CQC Prephenate dehydratase E4K02_RS08165 ENOG4105C1G acyl-Coa dehydrogenase E4K02_RS08170 ENOG4105CK2 sodium dicarboxylate symporter E4K02_RS08185 ENOG4105VUT cytoplasmic protein E4K02_RS08190 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) E4K02_RS08195 ENOG4105BZ4 penicillin-binding protein E4K02_RS08205 ENOG4105M6F mutator MutT protein E4K02_RS08215 ENOG4105DHQ Histidine kinase E4K02_RS08220 ENOG4105XJC Two component transcriptional regulator (Winged helix family E4K02_RS08230 ENOG4107QHF type ii secretion system protein e E4K02_RS08240 ENOG4108R96 Methyltransferase, YaeB family E4K02_RS08245 ENOG4105DP0 ferredoxin-NADP reductase E4K02_RS08250 ENOG4105JAB phenazine biosynthesis protein, phzf family E4K02_RS08255 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E4K02_RS08260 ENOG4105CFP Peptidase U32 E4K02_RS08265 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding E4K02_RS08280 ENOG4105ENT Efflux transporter rnd family, mfp subunit E4K02_RS08290 ENOG4105ENJ RND efflux system, outer membrane lipoprotein E4K02_RS08325 ENOG4105DA5 (ABC) transporter E4K02_RS08330 ENOG4105E3A (ABC) transporter E4K02_RS08345 ENOG4105CNI cell division protein FtsW E4K02_RS08350 ENOG4105CVE Lytic murein transglycosylase E4K02_RS08390 ENOG4105CE9 30S ribosomal protein S2 E4K02_RS08395 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) E4K02_RS08405 ENOG4107RNU major facilitator superfamily MFS_1 E4K02_RS08415 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) E4K02_RS08420 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) E4K02_RS08425 ENOG4107QPN acyl-Coa dehydrogenase E4K02_RS08440 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) E4K02_RS08445 ENOG4105SYT Methylenetetrahydrofolate reductase E4K02_RS08450 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) E4K02_RS08455 ENOG4105BZU Histidine kinase E4K02_RS08460 ENOG4105C6K Malic enzyme E4K02_RS08470 ENOG4105C0H protease E4K02_RS08475 ENOG4107QNR UPF0135 protein E4K02_RS08480 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E4K02_RS08515 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) E4K02_RS08530 ENOG4105DUX Transporter E4K02_RS08560 ENOG4105DDQ anthranilate synthase E4K02_RS08565 ENOG4105CD8 aminopeptidase N E4K02_RS08595 ENOG4105C7W Xanthine dehydrogenase E4K02_RS08605 ENOG4105EUJ GTP cyclohydrolase i E4K02_RS08625 ENOG4105NX3 Membrane E4K02_RS08660 ENOG4105BZ1 (ABC) transporter E4K02_RS08675 ENOG4105WQI isochorismatase E4K02_RS08680 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase E4K02_RS08685 ENOG4105C0W non-ribosomal peptide synthetase E4K02_RS08705 ENOG4108IPW abc transporter atp-binding protein E4K02_RS08720 ENOG4105CEY Amp-dependent synthetase and ligase E4K02_RS08735 ENOG4105WWK YheO domain protein E4K02_RS08745 ENOG4105C2I pirin domain protein E4K02_RS08775 ENOG4105VCD cytoplasmic protein E4K02_RS08780 ENOG4105D22 carbon starvation protein E4K02_RS08790 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein E4K02_RS08800 ENOG41066DG (EAL) domain protein E4K02_RS08810 ENOG4105DHU Bile acid E4K02_RS08825 ENOG4105DAN ATP-dependent protease E4K02_RS08830 ENOG4105EJC lysr family transcriptional regulator E4K02_RS08835 ENOG4108K5P (LipO)protein E4K02_RS08855 ENOG4105DZ1 carboxypeptidase E4K02_RS08860 ENOG4108Z0R Transferase E4K02_RS08880 ENOG4107QTF adenylosuccinate lyase E4K02_RS08895 ENOG4105ERU peptidase E4K02_RS08900 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) E4K02_RS08910 ENOG4105C8U phosphate abc transporter E4K02_RS08915 ENOG4105CVA phosphate E4K02_RS08920 ENOG4105C85 amino acid E4K02_RS08925 ENOG4107RA9 decarboxylase E4K02_RS08930 ENOG4105F7P transcriptional regulator AsnC family E4K02_RS08940 ENOG4105DY8 decarboxylase E4K02_RS08945 ENOG4108JPW Aminotransferase E4K02_RS08960 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein E4K02_RS08970 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) E4K02_RS08985 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) E4K02_RS08990 ENOG4105D3G Pseudouridine synthase E4K02_RS09005 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) E4K02_RS09035 ENOG4105JAB phenazine biosynthesis protein, phzf family E4K02_RS09040 ENOG4108ETY sodium dicarboxylate symporter E4K02_RS09045 ENOG4105EGI Transcriptional regulator E4K02_RS09050 ENOG4105CBP Major Facilitator E4K02_RS09075 ENOG4108R99 pseudouridine synthase E4K02_RS09080 ENOG4105E9K Isocitrate dehydrogenase E4K02_RS09090 ENOG4105DZ1 carboxypeptidase E4K02_RS09095 ENOG4105CEP NADH dehydrogenase E4K02_RS09100 ENOG4108YZY peptidylprolyl cis-trans isomerase E4K02_RS09105 ENOG4105CVP deoxyribo-dipyrimidine photolyase E4K02_RS09120 ENOG4107R8N Glycosyl transferase, family 2 E4K02_RS09150 ENOG4105EA8 2-Nitropropane dioxygenase E4K02_RS09155 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) E4K02_RS09160 ENOG4107QS8 (LipO)protein E4K02_RS09195 ENOG4105DTR rard protein E4K02_RS09205 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) E4K02_RS09215 ENOG4105BZU Histidine kinase E4K02_RS09255 ENOG4105EMU Dehydrogenase E4K02_RS09260 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase E4K02_RS09265 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) E4K02_RS09270 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) E4K02_RS09280 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) E4K02_RS09295 ENOG4105C3F Signal peptidase i E4K02_RS09310 ENOG4105C0H protease E4K02_RS09315 ENOG4108IYU L-aspartate oxidase E4K02_RS09330 ENOG4105HHA aminodeoxychorismate lyase E4K02_RS09335 ENOG4105YAZ 4-amino-4-deoxychorismate lyase E4K02_RS09340 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein E4K02_RS09350 ENOG4108I5D sulfate abc transporter E4K02_RS09360 ENOG4108IJ6 ABC transporter E4K02_RS09365 ENOG4107R11 Transcriptional regulator E4K02_RS09380 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) E4K02_RS09385 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) E4K02_RS09400 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E4K02_RS09415 ENOG4108UKI Enoyl-CoA hydratase E4K02_RS09425 ENOG4105C2C drug resistance transporter, Bcr CflA E4K02_RS09430 ENOG4108ETH Formylglycinamide ribotide synthetase E4K02_RS09450 ENOG4105CH2 amidohydrolase E4K02_RS09455 ENOG4107YD3 Thioesterase E4K02_RS09460 ENOG4105E02 MotA TolQ exbB proton channel E4K02_RS09465 ENOG4105M8F Biopolymer transport protein exbD tolR E4K02_RS09475 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) E4K02_RS09480 ENOG4105KCK Peptidoglycan-associated lipoprotein E4K02_RS09530 ENOG4105C02 permease E4K02_RS09540 ENOG4108V3E phosphoribosylglycinamide formyltransferase E4K02_RS09545 ENOG4107R6F Alpha Beta Hydrolase Fold protein E4K02_RS09550 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) E4K02_RS09560 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 E4K02_RS09565 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) E4K02_RS09570 ENOG4105D60 lipoprotein releasing system transmembrane protein E4K02_RS09600 ENOG4107KET secretion protein, HlyD family E4K02_RS09635 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E4K02_RS09640 ENOG4105C10 Electron transfer flavoprotein E4K02_RS09645 ENOG4105BZJ Electron transfer flavoprotein E4K02_RS09650 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E4K02_RS09655 ENOG4105N14 lysine exporter protein LysE YggA E4K02_RS09665 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) E4K02_RS09675 ENOG4105C85 amino acid E4K02_RS09680 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) E4K02_RS09690 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) E4K02_RS09710 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit E4K02_RS09715 ENOG4105BZW Glycerate kinase E4K02_RS09750 ENOG4105YCT UPF0386 protein E4K02_RS09775 ENOG4105CEY Amp-dependent synthetase and ligase E4K02_RS09790 ENOG4108RRZ Transcription elongation factor GreB E4K02_RS09815 ENOG4105E4C Lytic transglycosylase catalytic E4K02_RS09830 ENOG4105BZS acriflavin resistance protein E4K02_RS09835 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase E4K02_RS09845 ENOG41080IJ Diacylglycerol kinase E4K02_RS09860 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) E4K02_RS09875 ENOG4105C6V Glycerol-3-phosphate dehydrogenase E4K02_RS09880 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) E4K02_RS09885 ENOG4105CSH Transporter E4K02_RS09935 ENOG4105EEI dihydropteroate synthase E4K02_RS09940 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) E4K02_RS09950 ENOG4105HBR Rna-binding protein E4K02_RS09965 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain E4K02_RS09970 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain E4K02_RS09980 ENOG4108IG5 Transcriptional regulator E4K02_RS09985 ENOG4108UQ8 endoribonuclease L-psp E4K02_RS09995 ENOG41080TK Universal stress protein E4K02_RS10010 ENOG4105PNM synthesis protein E4K02_RS10045 ENOG4105EEQ Na H antiporter E4K02_RS10050 ENOG4105CGZ zinc metallopeptidase E4K02_RS10055 ENOG4105CKW Inner membrane protein yedI E4K02_RS10065 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha E4K02_RS10075 ENOG4107QN2 dihydrolipoyl dehydrogenase E4K02_RS10080 ENOG4105C7S Dehydrogenase E4K02_RS10085 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 E4K02_RS10100 ENOG4105E33 succinate dehydrogenase E4K02_RS10110 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein E4K02_RS10115 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit E4K02_RS10145 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E4K02_RS10150 ENOG41084BA UPF0250 protein E4K02_RS10155 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) E4K02_RS10170 ENOG4105CUB amino acid E4K02_RS10180 ENOG4105KVH Transcriptional regulator E4K02_RS10185 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) E4K02_RS10190 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) E4K02_RS10205 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) E4K02_RS10235 ENOG410841Q phosphoesterase PA-phosphatase related protein E4K02_RS10240 ENOG4105C1P efflux transporter, rnd family, mfp subunit E4K02_RS10245 ENOG4105BZS acriflavin resistance protein E4K02_RS10250 ENOG4105ENJ RND efflux system, outer membrane lipoprotein E4K02_RS10270 ENOG4105K8R UPF0145 protein E4K02_RS10275 ENOG4105K8R UPF0145 protein E4K02_RS10295 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) E4K02_RS10320 ENOG4105DHQ Histidine kinase E4K02_RS10325 ENOG4105XJC Two component transcriptional regulator (Winged helix family E4K02_RS10330 ENOG4105DIJ Phosphoethanolamine transferase E4K02_RS10350 ENOG4105D78 K07001 NTE family protein E4K02_RS10365 ENOG4105MSB protein, conserved in bacteria E4K02_RS10370 ENOG4105CTB Polyprenyl synthetase E4K02_RS10375 ENOG4105C7F AcnD-accessory protein PrpF E4K02_RS10380 ENOG4105C85 amino acid E4K02_RS10400 ENOG4105CF7 AraC family transcriptional regulator E4K02_RS10425 ENOG4108X0B nad(p)h dehydrogenase (quinone) E4K02_RS10435 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein E4K02_RS10445 ENOG4105D8T Acyltransferase E4K02_RS10455 ENOG4105C03 ribonuclease E4K02_RS10460 ENOG4108Z03 MAF-like protein E4K02_RS10465 ENOG4105VQ7 Rod shape-determining protein MreD E4K02_RS10470 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) E4K02_RS10480 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) E4K02_RS10490 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) E4K02_RS10515 ENOG4105C9K Endothelin-converting enzyme 1 E4K02_RS10520 ENOG4105F9F transposase E4K02_RS10540 ENOG4105C7B Threonine dehydratase E4K02_RS10545 ENOG4105D78 K07001 NTE family protein E4K02_RS10550 ENOG4105BZG amino acid carrier protein E4K02_RS10570 ENOG4105C2C drug resistance transporter, Bcr CflA E4K02_RS10575 ENOG4105EM2 membrane E4K02_RS10625 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E4K02_RS10630 ENOG4105WD1 Membrane E4K02_RS10640 ENOG4107PEH Entericidin EcnA/B family E4K02_RS10660 ENOG4105C8Q Methyl-accepting chemotaxis E4K02_RS10665 ENOG4108ZGA chew protein E4K02_RS10670 ENOG4105M3Z response regulator E4K02_RS10675 ENOG4108UNF response regulator E4K02_RS10705 ENOG4105KWI UPF0339 protein E4K02_RS10710 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA E4K02_RS10715 ENOG4105K78 MarR family Transcriptional regulator E4K02_RS10720 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) E4K02_RS10725 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) E4K02_RS10730 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) E4K02_RS10735 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) E4K02_RS10740 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) E4K02_RS10745 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) E4K02_RS10750 ENOG4105C2W permease E4K02_RS10765 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) E4K02_RS10770 ENOG4105T95 Thiol disulfide interChange protein E4K02_RS10780 ENOG4108N2Y auxin Efflux E4K02_RS10785 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E4K02_RS10790 ENOG4105CHB tonB-dependent Receptor E4K02_RS10795 ENOG4108VX5 3-methyladenine DNA glycosylase E4K02_RS10805 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) E4K02_RS10820 ENOG4105CI3 gtp-binding protein typa E4K02_RS10825 ENOG4105C2W permease E4K02_RS10835 ENOG4108IQI permease E4K02_RS10840 ENOG4105E0Y RtcB Protein E4K02_RS10845 ENOG4108WHA ompa motb domain protein E4K02_RS10855 ENOG4105CHU acetyl-coa acetyltransferase E4K02_RS10875 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) E4K02_RS10880 ENOG4105DZG Dehydrogenase E4K02_RS10885 ENOG4105TW1 Carbohydrate-selective porin OprB E4K02_RS10895 ENOG4108R6W Transcriptional regulator, ARAC family E4K02_RS10900 ENOG4105CHU acetyl-coa acetyltransferase E4K02_RS10930 ENOG4108UT2 hemolysin iii E4K02_RS10950 ENOG4105D3R alkyl hydroperoxide reductase E4K02_RS10970 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase E4K02_RS11020 ENOG4108WBT adenosyltransferase E4K02_RS11040 ENOG4105CNG UPF0061 protein E4K02_RS11045 ENOG4105E3W Two component transcriptional regulator (Winged helix family E4K02_RS11050 ENOG4105EB3 Histidine kinase E4K02_RS11060 ENOG4105CSU acyl-Coa dehydrogenase E4K02_RS11065 ENOG4105CSU acyl-Coa dehydrogenase E4K02_RS11070 ENOG4108VY7 phosphate-starvation-inducible protein PsiE E4K02_RS11090 ENOG4105UGU tonB-dependent Receptor E4K02_RS11120 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase E4K02_RS11130 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase E4K02_RS11135 ENOG4105C1B dTDP-glucose 4-6-dehydratase E4K02_RS11145 ENOG4107TYR Glycosyl Transferase E4K02_RS11150 ENOG4107BJW polysaccharide deacetylase E4K02_RS11160 ENOG4105CM2 brancheD-chain amino acid aminotransferase E4K02_RS11165 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) E4K02_RS11170 ENOG4105BZU Histidine kinase E4K02_RS11205 ENOG4105VIE preprotein translocase, subunit YajC E4K02_RS11210 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) E4K02_RS11215 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) E4K02_RS11230 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase E4K02_RS11240 ENOG4105FFC UPF0187 protein E4K02_RS11245 ENOG4105DB7 PHP domain protein E4K02_RS11255 ENOG4105K9H YciI-like protein E4K02_RS11285 ENOG4105NAU thioesterase Superfamily protein E4K02_RS11310 ENOG4107QN2 dihydrolipoyl dehydrogenase E4K02_RS11345 ENOG4108KHX Diguanylate cyclase E4K02_RS11350 ENOG4105UYK outer membrane protein a E4K02_RS11360 ENOG4107RZC phospholipase d E4K02_RS11370 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) E4K02_RS11400 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) E4K02_RS11405 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) E4K02_RS11410 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) E4K02_RS11420 ENOG4108UJD 30S ribosomal protein S9 E4K02_RS11425 ENOG4107MKT Stringent starvation protein a E4K02_RS11430 ENOG4105KB2 stringent starvation protein b E4K02_RS11450 ENOG4105C1G acyl-Coa dehydrogenase E4K02_RS11455 ENOG4107QX3 carboxylase E4K02_RS11470 ENOG4108RZE Tetr family transcriptional regulator E4K02_RS11475 ENOG4105C1G acyl-Coa dehydrogenase E4K02_RS11520 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase E4K02_RS11525 ENOG4105D6S protein involved in catabolism of external DNA E4K02_RS11555 ENOG4105E4C Lytic transglycosylase catalytic E4K02_RS11565 ENOG4105C9A Phoh family E4K02_RS11595 ENOG4105CS1 NAD(P)H quinone oxidoreductase E4K02_RS11600 ENOG4107S2Z UPF0761 membrane protein E4K02_RS11610 ENOG4108K2B transcriptional regulator E4K02_RS11615 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase E4K02_RS11635 ENOG4105F9F transposase E4K02_RS11665 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) E4K02_RS11670 ENOG4105DGW oligopeptidase A E4K02_RS11675 ENOG4105VKU nucleicacid-binding protein E4K02_RS11710 ENOG4105C1G acyl-Coa dehydrogenase E4K02_RS11750 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) E4K02_RS11860 ENOG41089BK Glutamine amido-transferase E4K02_RS11870 ENOG4105D7A ATP-binding protein E4K02_RS11885 ENOG4105KPV Transcriptional regulator E4K02_RS11900 ENOG4105CK2 sodium dicarboxylate symporter E4K02_RS11905 ENOG4105C29 acyl-CoA thioesterase E4K02_RS11925 ENOG4105CB5 ATP-dependent DNA helicase recG E4K02_RS11930 ENOG4105MJ2 Competence protein E4K02_RS11940 ENOG4108URH decarboxylase E4K02_RS11945 ENOG4105D7N magnesium and cobalt transport protein CorA E4K02_RS11955 ENOG4105E3I toluene tolerance E4K02_RS11965 ENOG4105CY3 ABC transporter, permease E4K02_RS11970 ENOG4105DHJ ABC, transporter E4K02_RS11980 ENOG4105C1J atp-dependent rna helicase E4K02_RS11985 ENOG4105ECY inositol monophosphatase E4K02_RS12000 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) E4K02_RS12015 ENOG4105F9F transposase E4K02_RS12025 ENOG4105CSU acyl-Coa dehydrogenase E4K02_RS12035 ENOG41067S9 phage shock protein C, PspC E4K02_RS12040 ENOG4105W87 Cbs domain E4K02_RS12125 ENOG4105C26 Dehydrogenase E4K02_RS12135 ENOG4105C8Y Acetylornithine aminotransferase E4K02_RS12140 ENOG4105D82 Glutamate dehydrogenase E4K02_RS12145 ENOG4105F9F transposase E4K02_RS12150 ENOG4108IQI permease E4K02_RS12180 ENOG4107SKI cobyrinic Acid a,c-diamide synthase E4K02_RS12185 ENOG4105IPI Membrane E4K02_RS12190 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E4K02_RS12195 ENOG4105EM2 membrane E4K02_RS12200 ENOG4107QF7 multi-drug E4K02_RS12210 ENOG4105NF4 modulator of drug activity E4K02_RS12215 ENOG4105VRH Antibiotic biosynthesis monooxygenase E4K02_RS12225 ENOG4105CQB FAD linked oxidase domain protein E4K02_RS12230 ENOG4108JQ1 Dehydrogenase E4K02_RS12255 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) E4K02_RS12260 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) E4K02_RS12265 ENOG4107IFA Lipase (EC 3.1.1.3) E4K02_RS12280 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) E4K02_RS12330 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) E4K02_RS12345 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) E4K02_RS12350 ENOG4105KME endoribonuclease L-psp E4K02_RS12360 ENOG4108UQY Iron-storage protein E4K02_RS12365 ENOG4108YSG O-Antigen polymerase E4K02_RS12375 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A E4K02_RS12390 ENOG4105HA9 of methanol dehydrogenase type E4K02_RS12395 ENOG4108V0P LemA family E4K02_RS12405 ENOG4105BZ8 glutamate synthase E4K02_RS12410 ENOG4105CBC glutamate synthase E4K02_RS12465 ENOG4108JQC penicillin-binding protein 1A E4K02_RS12470 ENOG4105DHI Methyltransferase E4K02_RS12485 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) E4K02_RS12490 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) E4K02_RS12495 ENOG4105CJN penicillin-binding protein E4K02_RS12510 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein E4K02_RS12535 ENOG4108IQI permease E4K02_RS12555 ENOG4105DFP Integrase E4K02_RS12610 ENOG4105F9F transposase E4K02_RS12615 ENOG4105EUZ Beta-lactamase domain protein E4K02_RS12635 ENOG4105F9F transposase E4K02_RS12750 ENOG4105C5H ABC transporter E4K02_RS12760 ENOG4105PDP Short chain dehydrogenase E4K02_RS12765 ENOG4105CHH sulfate transporter E4K02_RS12780 ENOG4105E0F Histidine kinase E4K02_RS12790 ENOG4105CYC Transferase E4K02_RS12795 ENOG4108R6G acetyltransferase E4K02_RS12820 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) E4K02_RS12840 ENOG4105BZ1 (ABC) transporter E4K02_RS12860 ENOG41061CK Antibiotic biosynthesis monooxygenase E4K02_RS12875 ENOG4105CUV Homoserine Kinase E4K02_RS12965 ENOG4105CDU Replicative dna helicase E4K02_RS13115 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) E4K02_RS13140 ENOG4105EUB pirin domain protein E4K02_RS13145 ENOG4105CHJ isochorismatase hydrolase E4K02_RS13155 ENOG4105C26 Dehydrogenase E4K02_RS13160 ENOG4108JPW Aminotransferase E4K02_RS13170 ENOG4105C85 amino acid E4K02_RS13180 ENOG4108UMN azlc family E4K02_RS13190 ENOG4108UUM single-stranded DNA-binding protein E4K02_RS13195 ENOG4107RDB Major Facilitator E4K02_RS13205 ENOG4105DWF phosphomethylpyrimidine kinase E4K02_RS13210 ENOG4105RA2 Membrane E4K02_RS13220 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein E4K02_RS13225 ENOG4108WUH Transcriptional regulator, TetR family E4K02_RS13230 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) E4K02_RS13235 ENOG4105BZU Histidine kinase E4K02_RS13245 ENOG4105C94 Transporter E4K02_RS13255 ENOG4107QN1 sodium solute E4K02_RS13260 ENOG41062QD Membrane E4K02_RS13265 ENOG4105BZU Histidine kinase E4K02_RS13280 ENOG4108UZX fmn reductase E4K02_RS13285 ENOG4105FBW Monooxygenase E4K02_RS13295 ENOG4108W2Y isochorismatase E4K02_RS13300 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) E4K02_RS13310 ENOG4105D64 Mechanosensitive ion channel E4K02_RS13320 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase E4K02_RS13325 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E4K02_RS13350 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) E4K02_RS13365 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) E4K02_RS13380 ENOG4105E0K tonB-dependent siderophore receptor E4K02_RS13395 ENOG4107QSN dihydrolipoamide acetyltransferase E4K02_RS13400 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) E4K02_RS13405 ENOG41063SB peptidase E4K02_RS13420 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) E4K02_RS13425 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) E4K02_RS13430 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) E4K02_RS13450 ENOG4105D7Z glutathione synthase E4K02_RS13490 ENOG4105CGK Exodeoxyribonuclease III E4K02_RS13495 ENOG4105KUZ arsenate reductase E4K02_RS13510 ENOG4105BZU Histidine kinase E4K02_RS13515 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) E4K02_RS13545 ENOG41084YZ Hydrolase E4K02_RS13560 ENOG41061H0 Monooxygenase E4K02_RS13570 ENOG4108Z2U ureidoglycolate hydrolase E4K02_RS13575 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E4K02_RS13580 ENOG4105IPS esterase E4K02_RS13615 ENOG4105D9M gamma-glutamylcysteine synthetase E4K02_RS13630 ENOG4106BRA Membrane E4K02_RS13635 ENOG4105CHM Aminotransferase E4K02_RS13640 ENOG4107QJQ Mate efflux family protein E4K02_RS13655 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E4K02_RS13660 ENOG4105BZU Histidine kinase E4K02_RS13675 ENOG4107SCA Formamidase (EC 3.5.1.49) E4K02_RS13685 ENOG4105KHC sulfurtransferase E4K02_RS13735 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) E4K02_RS13750 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) E4K02_RS13755 ENOG4108ZAI phosphatidylglycerophosphatase a E4K02_RS13765 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) E4K02_RS13770 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) E4K02_RS13775 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 E4K02_RS13785 ENOG41088SP formiminoglutamate hydrolase E4K02_RS13795 ENOG4105C85 amino acid E4K02_RS13810 ENOG41090B9 response to stress E4K02_RS13815 ENOG4105CZE histidine utilization repressor E4K02_RS13825 ENOG4105CKI cobalamin synthesis protein E4K02_RS13835 ENOG4105F9F transposase E4K02_RS13840 ENOG4105C85 amino acid E4K02_RS13850 ENOG4108RXX maleylacetoacetate isomerase E4K02_RS13870 ENOG4105EWC Purine nucleoside phosphorylase E4K02_RS13875 ENOG4107QI1 Mate efflux family protein E4K02_RS13880 ENOG4105C09 Bile acid E4K02_RS13885 ENOG4108RWI nicotinamidase E4K02_RS13890 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) E4K02_RS13910 ENOG4105S64 Formate nitrite transporter E4K02_RS13915 ENOG4105D1H recombination factor protein RarA E4K02_RS13925 ENOG4108ZZ3 UPF0260 protein E4K02_RS13945 ENOG4105CEN a g-specific adenine glycosylase E4K02_RS13960 ENOG4108R3E Dna-3-methyladenine glycosylase i E4K02_RS13965 ENOG4105DQ4 alcohol dehydrogenase E4K02_RS13985 ENOG4105HEI LysR family (Transcriptional regulator E4K02_RS13990 ENOG4105CV8 reductase E4K02_RS13995 ENOG4105F27 Major Facilitator E4K02_RS14030 ENOG4105DJY efflux transporter, rnd family, mfp subunit E4K02_RS14035 ENOG4108IG5 Transcriptional regulator E4K02_RS14045 ENOG4105C2W permease E4K02_RS14050 ENOG4108W5M transcriptional regulator E4K02_RS14075 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B E4K02_RS14085 ENOG4105C8J )-transporter E4K02_RS14130 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) E4K02_RS14135 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) E4K02_RS14140 ENOG4105D74 hydrolase E4K02_RS14150 ENOG4108821 RND type efflux pump E4K02_RS14155 ENOG4108821 RND type efflux pump E4K02_RS14160 ENOG4108821 RND type efflux pump E4K02_RS14165 ENOG4105C5H ABC transporter E4K02_RS14170 ENOG4105DQR SNARE associated Golgi E4K02_RS14180 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E4K02_RS14190 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) E4K02_RS14215 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins E4K02_RS14230 ENOG4105PGM cation diffusion facilitator family transporter E4K02_RS14235 ENOG4105T95 Thiol disulfide interChange protein E4K02_RS14245 ENOG4108UGV hypoxanthine phosphoribosyltransferase E4K02_RS14250 ENOG4107QUY Guanine deaminase E4K02_RS14260 ENOG4106032 Glutathionylspermidine synthase E4K02_RS14270 ENOG4105DU1 integral membrane protein, terc E4K02_RS14275 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase E4K02_RS14280 ENOG4105D5G Transposase E4K02_RS14290 ENOG4105DFU Cell wall formation (By similarity) E4K02_RS14305 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) E4K02_RS14310 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit E4K02_RS14315 ENOG4105CVE Lytic murein transglycosylase E4K02_RS14385 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) E4K02_RS14425 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase E4K02_RS14435 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) E4K02_RS14440 ENOG4105DTN riboflavin biosynthesis protein ribF E4K02_RS14450 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) E4K02_RS14455 ENOG4108R86 Transcriptional regulator E4K02_RS14460 ENOG4108VM9 ABC, transporter E4K02_RS14465 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component E4K02_RS14470 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) E4K02_RS14475 ENOG4105GVF (ABC) transporter E4K02_RS14480 ENOG4105GVF (ABC) transporter E4K02_RS14485 ENOG4107QZM n-acetylglutamate synthase E4K02_RS14500 ENOG4105UBK short-chain dehydrogenase reductase E4K02_RS14505 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) E4K02_RS14515 ENOG4108Z33 Thiol disulfide Interchange Protein E4K02_RS14520 ENOG41062JF Transcriptional regulator E4K02_RS14545 ENOG4105HSS phospholipase C E4K02_RS14555 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase E4K02_RS14560 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase E4K02_RS14565 ENOG4105CJR Integral membrane protein (MviN E4K02_RS14570 ENOG4108V1T peptidylprolyl cis-trans isomerase E4K02_RS14575 ENOG4108V1T peptidylprolyl cis-trans isomerase E4K02_RS14580 ENOG4105D75 Capsular exopolysaccharide family E4K02_RS14590 ENOG4105DAY polysaccharide export protein E4K02_RS14595 ENOG4107QQG Dehydrogenase E4K02_RS14605 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase E4K02_RS14610 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase E4K02_RS14615 ENOG4105D2T synthase E4K02_RS14630 ENOG4105F0R Cytidylyltransferase E4K02_RS14665 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase E4K02_RS14680 ENOG4107UKG Glycosyl transferase, family 4 E4K02_RS14685 ENOG4105D3Q Sugar transferase E4K02_RS14690 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase E4K02_RS14695 ENOG4105C6Y Udp-glucose 6-dehydrogenase E4K02_RS14705 ENOG4105CMR udp-glucose 4-epimerase E4K02_RS14710 ENOG4107QKV phosphomannomutase E4K02_RS14715 ENOG4105DAA L-lactate E4K02_RS14720 ENOG41073TP transcriptional regulator E4K02_RS14730 ENOG4105CXG d-lactate dehydrogenase E4K02_RS14735 ENOG4105CGF Aromatic amino acid aminotransferase E4K02_RS14745 ENOG4105DRR Transcriptional regulator, GntR family E4K02_RS14750 ENOG4105CR4 methylisocitrate lyase E4K02_RS14755 ENOG4105BZN citrate synthase E4K02_RS14760 ENOG4108I0Z Aconitate hydratase E4K02_RS14820 ENOG4105D3G Pseudouridine synthase E4K02_RS14855 ENOG4105EW9 transcriptional regulator AsnC family E4K02_RS14870 ENOG4105M4H endoribonuclease L-psp E4K02_RS14875 ENOG4105C85 amino acid E4K02_RS14880 ENOG4105C85 amino acid E4K02_RS14890 ENOG4105C26 Dehydrogenase E4K02_RS14895 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E4K02_RS14905 ENOG4105C1G acyl-Coa dehydrogenase E4K02_RS14910 ENOG4105E39 Enoyl-CoA hydratase E4K02_RS14915 ENOG4105E39 Enoyl-CoA hydratase E4K02_RS14920 ENOG4105CSH Transporter E4K02_RS14955 ENOG4107PSF BolA-like protein E4K02_RS14965 ENOG4107QJE Chromosome Partitioning Protein E4K02_RS14980 ENOG4105DQR SNARE associated Golgi E4K02_RS14985 ENOG4108VBZ doxx family E4K02_RS14990 ENOG4106MP8 UPF0754 membrane protein E4K02_RS14995 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) E4K02_RS15015 ENOG4105EUB pirin domain protein E4K02_RS15045 ENOG4107R1I NAD-dependent malic enzyme E4K02_RS15050 ENOG4105EZR dyp-type peroxidase family protein E4K02_RS15055 ENOG410829K Lysine exporter protein (Lyse ygga) E4K02_RS15060 ENOG4105FAV ABC, transporter E4K02_RS15065 ENOG4105FDK ABC transporter E4K02_RS15125 ENOG41090VV Protein of unknown function (DUF2846) E4K02_RS15135 ENOG4108V06 Glutathione peroxidase E4K02_RS15145 ENOG4107RTG Major Facilitator superfamily E4K02_RS15150 ENOG4108IND Tetr family transcriptional regulator E4K02_RS15165 ENOG4105C79 DNA protecting protein DprA E4K02_RS15200 ENOG4105Y7M Transcriptional regulator, TetR family E4K02_RS15235 ENOG4105C6T cysteine synthase E4K02_RS15255 ENOG4105CCT upf0313 protein E4K02_RS15270 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) E4K02_RS15280 ENOG4105C0R drug resistance transporter emrb qaca subfamily E4K02_RS15285 ENOG4108URH decarboxylase E4K02_RS15290 ENOG4105EE5 Membrane protein terC E4K02_RS15295 ENOG4105K5B UPF0225 protein E4K02_RS15300 ENOG4105EN6 Membrane E4K02_RS15305 ENOG41079KZ Major Facilitator Superfamily E4K02_RS15310 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E4K02_RS15315 ENOG4105CEY Amp-dependent synthetase and ligase E4K02_RS15330 ENOG4105F0N pyrophosphate phospho-hydrolase E4K02_RS15335 ENOG4105EPF Outer membrane porin E4K02_RS15350 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) E4K02_RS15355 ENOG4105FB2 class II Aldolase E4K02_RS15360 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E4K02_RS15380 ENOG4105CE1 Ferrous iron transport protein b E4K02_RS15455 ENOG4108ZIT Ferredoxin, 2FE-2S E4K02_RS15475 ENOG4107YCR Transcriptional regulator, ARSR family E4K02_RS15480 ENOG4105PGM cation diffusion facilitator family transporter E4K02_RS15530 ENOG4105C0P Mg chelatase subunit ChlI E4K02_RS15545 ENOG4105BZU Histidine kinase E4K02_RS15555 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) E4K02_RS15600 ENOG4108K5H permease YjgP YjgQ family protein E4K02_RS15605 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) E4K02_RS15610 ENOG4105CN1 protease E4K02_RS15615 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E4K02_RS15620 ENOG4107TUY Histidine kinase E4K02_RS15630 ENOG41061WM D-Alanyl-D-Alanine E4K02_RS15640 ENOG4105D6E homoserine dehydrogenase E4K02_RS15645 ENOG4105T95 Thiol disulfide interChange protein E4K02_RS15650 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E4K02_RS15660 ENOG4105CE1 Ferrous iron transport protein b E4K02_RS15675 ENOG4105CNI cell division protein FtsW E4K02_RS15680 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) E4K02_RS15690 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) E4K02_RS15715 ENOG4108RNG Permease of the drug metabolite transporter E4K02_RS15720 ENOG4105DFG type I secretion outer membrane protein E4K02_RS15725 ENOG4108UTW Plays a role in the regulation of phosphate uptake E4K02_RS15740 ENOG4108HRK Histidine kinase E4K02_RS15745 ENOG4108NEV two component transcriptional regulator, LytTR family E4K02_RS15750 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) E4K02_RS15775 ENOG4105F9F transposase E4K02_RS15785 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS E4K02_RS15800 ENOG4105GVR general secretion pathway protein D E4K02_RS15805 ENOG4105TV9 FHA Domain-Containing protein E4K02_RS15810 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) E4K02_RS15850 ENOG4105PM1 preprotein translocase subunit SecE E4K02_RS15855 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) E4K02_RS15910 ENOG4105D3Y Na H antiporter E4K02_RS15915 ENOG4105F9F transposase E4K02_RS15930 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) E4K02_RS15945 ENOG4107ZXU DSBA oxidoreductase E4K02_RS16000 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase E4K02_RS16005 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E4K02_RS16035 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) E4K02_RS16045 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) E4K02_RS16060 ENOG4105C2N RNA methyltransferase TrmH family group 3 E4K02_RS16070 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) E4K02_RS16095 ENOG4107EJC Preprotein translocase subunit SecG E4K02_RS16120 ENOG4105CHV Transcription elongation factor NusA E4K02_RS16135 ENOG4105KJM monovalent cation h antiporter subunit g E4K02_RS16140 ENOG4105W4C monovalent cation H antiporter subunit F E4K02_RS16145 ENOG4105SC1 monovalent cation H antiporter subunit E E4K02_RS16150 ENOG4107R4Z monovalent cation h antiporter subunit d E4K02_RS16155 ENOG4108ZE9 Monovalent cation H antiporter subunit C E4K02_RS16160 ENOG4105D65 subunit l E4K02_RS16175 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase E4K02_RS16180 ENOG41061H0 Monooxygenase E4K02_RS16195 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) E4K02_RS16205 ENOG4105CSR polyphosphate kinase 2 E4K02_RS16215 ENOG4105DSY exodeoxyribonuclease V, gamma E4K02_RS16220 ENOG4107QKA exodeoxyribonuclease V beta E4K02_RS16225 ENOG4107QYX exodeoxyribonuclease v alpha E4K02_RS16245 ENOG4107QUT magnesium and cobalt transport protein CorA E4K02_RS16250 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) E4K02_RS16255 ENOG4105DVC DnaJ domain protein E4K02_RS16270 ENOG4105CKD glutathione-regulated potassium-efflux system protein E4K02_RS16275 ENOG4105C25 Primosomal protein n' E4K02_RS16280 ENOG4105D7Q type ii secretion system E4K02_RS16285 ENOG4108VAU general secretion pathway protein G E4K02_RS16295 ENOG4108Z7R Chaperone CsaA E4K02_RS16300 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) E4K02_RS16305 ENOG4108JU5 Magnesium and cobalt efflux protein E4K02_RS16310 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) E4K02_RS16315 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase E4K02_RS16325 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) E4K02_RS16340 ENOG4105C5X domain protein E4K02_RS16345 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) E4K02_RS16355 ENOG4105BZ8 glutamate synthase E4K02_RS16390 ENOG4107T8P acyl-Coa dehydrogenase E4K02_RS16400 ENOG4107QI1 Mate efflux family protein E4K02_RS16410 ENOG4105CSA Coproporphyrinogen iii oxidase E4K02_RS16415 ENOG4105EMU Dehydrogenase E4K02_RS16420 ENOG4105CBN LysR family transcriptional regulator E4K02_RS16435 ENOG4105J5T Amp-dependent synthetase and ligase E4K02_RS16440 ENOG4105C03 ribonuclease E4K02_RS16450 ENOG4105EI2 Pseudouridine synthase E4K02_RS16455 ENOG4107XGZ Hydrolase E4K02_RS16460 ENOG4105D29 Helix-turn-helix type 11 domain protein E4K02_RS16475 ENOG4108W5M transcriptional regulator E4K02_RS16490 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase E4K02_RS16505 ENOG4105DUM transcriptional regulator, lysR family E4K02_RS16530 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) E4K02_RS16585 ENOG4105CK2 sodium dicarboxylate symporter E4K02_RS16595 ENOG4105D1S lipid A biosynthesis E4K02_RS16600 ENOG4105N14 lysine exporter protein LysE YggA E4K02_RS16605 ENOG4105C5H ABC transporter E4K02_RS16620 ENOG4105KVH Transcriptional regulator E4K02_RS16630 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) E4K02_RS16645 ENOG4105C4R Atp-dependent dna helicase E4K02_RS16650 ENOG4105VFU Rna-binding protein E4K02_RS16670 ENOG4105CKD glutathione-regulated potassium-efflux system protein E4K02_RS16685 ENOG4107RGH Aldehyde dehydrogenase E4K02_RS16695 ENOG4105CIY formyltetrahydrofolate deformylase E4K02_RS16795 ENOG4105DWV Homoserine O-trans-acetylase E4K02_RS16805 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) E4K02_RS16815 ENOG4108ESX Receptor E4K02_RS16825 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) E4K02_RS16845 ENOG4107GFK fumarate E4K02_RS16850 ENOG4108DNC Involved in acetate metabolism (By similarity) E4K02_RS16855 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) E4K02_RS16860 ENOG4105C01 Dihydroxy-acid dehydratase E4K02_RS16865 ENOG4108UHU Aldolase E4K02_RS16870 ENOG4105C6Z Gluconate E4K02_RS16875 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family E4K02_RS16880 ENOG4105C26 Dehydrogenase E4K02_RS16890 ENOG4106HB6 Alpha beta hydrolase E4K02_RS16905 ENOG4105CN1 protease E4K02_RS16920 ENOG4105WVQ Fe-S assembly protein IscX E4K02_RS16940 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) E4K02_RS16960 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) E4K02_RS16980 ENOG4105VW4 glutaredoxin 3 E4K02_RS16990 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) E4K02_RS16995 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) E4K02_RS17005 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH E4K02_RS17010 ENOG4105ENJ RND efflux system, outer membrane lipoprotein E4K02_RS17015 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) E4K02_RS17020 ENOG4105DJY efflux transporter, rnd family, mfp subunit E4K02_RS17045 ENOG4105C7K acetolactate synthase E4K02_RS17050 ENOG4108ZP8 Acetolactate synthase small subunit E4K02_RS17060 ENOG4105BZU Histidine kinase E4K02_RS17090 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) E4K02_RS17105 ENOG4105F8V Hydrolase, tatD family E4K02_RS17110 ENOG4107QM5 aconitate hydratase E4K02_RS17115 ENOG4105CUZ uba thif-type nad fad binding protein E4K02_RS17125 ENOG4107RSM transcriptional regulator E4K02_RS17135 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) E4K02_RS17150 ENOG4106UX7 integral membrane protein E4K02_RS17155 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) E4K02_RS17160 ENOG4105W8H transhydrogenase (subunit alpha E4K02_RS17165 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) E4K02_RS17180 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) E4K02_RS17185 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E4K02_RS17190 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase E4K02_RS17195 ENOG4105BZU Histidine kinase E4K02_RS17200 ENOG4105C6T cysteine synthase E4K02_RS17215 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) E4K02_RS17225 ENOG4105DXN mazG family E4K02_RS17230 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein E4K02_RS17235 ENOG4105DJ0 Poly(A) Polymerase E4K02_RS17240 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase E4K02_RS17260 ENOG41080Z8 PHOSPHOCARRIER protein E4K02_RS17265 ENOG4105N42 UPF0307 protein E4K02_RS17270 ENOG4105CEY Amp-dependent synthetase and ligase E4K02_RS17285 ENOG4105CYM Glutathione S-transferase E4K02_RS17290 ENOG4105W39 Membrane E4K02_RS17330 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) E4K02_RS17350 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) E4K02_RS17360 ENOG4105C9X ppx gppa phosphatase E4K02_RS17370 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) E4K02_RS17375 ENOG4105II7 pyrroline-5-carboxylate reductase E4K02_RS17380 ENOG4108VIA integral membrane protein E4K02_RS17385 ENOG4105C2M dna polymerase I E4K02_RS17405 ENOG4107QHF type ii secretion system protein e E4K02_RS17410 ENOG4108ZHJ Organic hydroperoxide resistance protein E4K02_RS17415 ENOG4105K56 Transcriptional regulator E4K02_RS17485 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) E4K02_RS17490 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) E4K02_RS17495 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) E4K02_RS17505 ENOG4105CRQ synthase (Component I) E4K02_RS17520 ENOG4105D5G Transposase E4K02_RS17535 ENOG4108Z0R Transferase E4K02_RS17540 ENOG41072GX Peptidase M22 Glycoprotease E4K02_RS17565 ENOG4105DJV ribulose-phosphate 3-epimerase E4K02_RS17570 ENOG4108HCJ Hydrolase E4K02_RS17580 ENOG4105E3B Multicopper oxidase E4K02_RS17585 ENOG4105VR0 copper resistance E4K02_RS17600 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E4K02_RS17605 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) E4K02_RS17610 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) E4K02_RS17645 ENOG4105ETT transcriptional Regulator, LysR family E4K02_RS17650 ENOG4105C1G acyl-Coa dehydrogenase E4K02_RS17655 ENOG4107RGD Major Facilitator superfamily E4K02_RS17660 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F E4K02_RS17680 ENOG4107EFR Flavocytochrome c E4K02_RS17685 ENOG4106P55 Transcriptional regulator E4K02_RS17705 ENOG4106P55 Transcriptional regulator E4K02_RS17715 ENOG4105ETT transcriptional Regulator, LysR family E4K02_RS17730 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) E4K02_RS17750 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E4K02_RS17760 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E4K02_RS17770 ENOG4107EXC regulatoR E4K02_RS17775 ENOG4105E0F Histidine kinase E4K02_RS17785 ENOG4105BZU Histidine kinase E4K02_RS17805 ENOG4105GKE subunit e E4K02_RS17810 ENOG4107QIZ NADH dehydrogenase E4K02_RS17815 ENOG4108IEH NADH dehydrogenase subunit g E4K02_RS17830 ENOG4107UFS subunit j E4K02_RS17840 ENOG4105D65 subunit l E4K02_RS17845 ENOG4105C8S subunit m E4K02_RS17865 ENOG4105DUM transcriptional regulator, lysR family E4K02_RS17870 ENOG4105DP0 ferredoxin-NADP reductase E4K02_RS17895 ENOG4105CBX hi0933 family E4K02_RS17900 ENOG4105K6H D-cysteine desulfhydrase E4K02_RS17930 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) E4K02_RS17940 ENOG4105D1F ATP-binding protein E4K02_RS18000 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) E4K02_RS18010 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY E4K02_RS18025 ENOG4105HF0 Membrane E4K02_RS18035 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) E4K02_RS18055 ENOG4106UW1 Major Facilitator superfamily E4K02_RS18060 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase E4K02_RS18065 ENOG4108K4C ec 3.1.3.12 E4K02_RS18070 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) E4K02_RS18080 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) E4K02_RS18085 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) E4K02_RS18095 ENOG4105FE9 pseudouridine synthase E4K02_RS18100 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) E4K02_RS18105 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) E4K02_RS18110 ENOG4107RTD sua5 ycio yrdc ywlc family protein E4K02_RS18115 ENOG4108BPE -transporting atpase E4K02_RS18120 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein E4K02_RS18130 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase E4K02_RS18135 ENOG4105CHR reductase E4K02_RS18145 ENOG4109066 lysm domain bon superfamily protein E4K02_RS18150 ENOG4105DWF phosphomethylpyrimidine kinase E4K02_RS18160 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) E4K02_RS18170 ENOG4105F9F transposase E4K02_RS18200 ENOG4105C5T Phosphoribosyl pyrophosphate synthase E4K02_RS18230 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) E4K02_RS18245 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) E4K02_RS18250 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane E4K02_RS18255 ENOG4105C34 Pseudouridine synthase E4K02_RS18260 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase E4K02_RS18465 ENOG4108YZA Nitrogen regulatory protein pii E4K02_RS18470 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) E4K02_RS18480 ENOG4105E3J oxidoreductase E4K02_RS18500 ENOG4105WH1 Two component transcriptional regulator luxr family E4K02_RS18505 ENOG4105BZU Histidine kinase E4K02_RS18510 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) E4K02_RS18535 ENOG4105FA0 parb-like partition protein E4K02_RS18540 ENOG4107QJE Chromosome Partitioning Protein E4K02_RS18595 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase E4K02_RS18600 ENOG4108BUD transposase E4K02_RS18605 ENOG4105E4P ATPase (AAA E4K02_RS18610 ENOG4108BUD transposase E4K02_RS18615 ENOG4108JUA Transcriptional regulator E4K02_RS18630 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) E4K02_RS18650 ENOG4105H3G oxidoreductase E4K02_RS18670 ENOG4105XUP Phage derived protein Gp49-like (DUF891) E4K02_RS18820 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E4K02_RS18825 ENOG4105VN1 Heat shock protein E4K02_RS18845 ENOG4107RT3 EamA-like transporter family E4K02_RS18860 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein E4K02_RS18865 ENOG4108WUH Transcriptional regulator, TetR family E4K02_RS18875 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E4K02_RS18885 ENOG4108I6A alcohol dehydrogenase E4K02_RS18895 ENOG4105C4W S-formylglutathione hydrolase E4K02_RS18930 ENOG4108BUD transposase E4K02_RS18940 ENOG4105E2A Dehydrogenase E4K02_RS18980 ENOG4105DJ2 Major Facilitator Superfamily E4K02_RS18990 ENOG4105F9F transposase E4K02_RS19015 ENOG4105VUH addiction module killer protein E4K02_RS19020 ENOG4105YES addiction module antidote protein E4K02_RS19030 ENOG4105VUH addiction module killer protein E4K02_RS19035 ENOG4105YES addiction module antidote protein E4K02_RS19040 ENOG4105EZV Transcriptional regulator E4K02_RS19090 ENOG4105EMU Dehydrogenase E4K02_RS19095 ENOG4108PZW LysR family Transcriptional regulator E4K02_RS19100 ENOG4107QPD alcohol dehydrogenase E4K02_RS19105 ENOG4108JA1 polyketide synthase E4K02_RS19130 ENOG4105CBC glutamate synthase E4K02_RS19135 ENOG4105M90 Glutamate synthase alpha subunit domain protein E4K02_RS19140 ENOG4105EYU Glutamine amido-transferase E4K02_RS19155 ENOG4105BZU Histidine kinase E4K02_RS19160 ENOG4105BZU Histidine kinase E4K02_RS19175 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) E4K02_RS19185 ENOG4105DDR sarcosine oxidase (Beta subunit) E4K02_RS19190 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) E4K02_RS19215 ENOG4105XUP Phage derived protein Gp49-like (DUF891) E4K02_RS19310 ENOG4105RPH Inner membrane protein YddG E4K02_RS19315 ENOG4105CSH Transporter E4K02_RS19325 ENOG4105ECQ AraC Family Transcriptional Regulator E4K02_RS19400 ENOG4107SKI cobyrinic Acid a,c-diamide synthase E4K02_RS19425 ENOG4105DIJ Phosphoethanolamine transferase E4K02_RS19475 ENOG4105K4U addiction module toxin, RelE StbE family E4K02_RS19480 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) E4K02_RS19485 ENOG4105KT5 UmuD protein