locus-tag	class	description
M1S39_RS00010	COG0592	DNA-directed DNA polymerase activity
M1S39_RS00020	COG0187	DNA topoisomerase II activity
M1S39_RS00030	COG0586	Pfam SNARE associated Golgi protein
M1S39_RS00035	COG0488	(ABC) transporter
M1S39_RS00060	COG0596	Alpha beta hydrolase
M1S39_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M1S39_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M1S39_RS00110	COG0733	neurotransmitter:sodium symporter activity
M1S39_RS00150	COG2233	PERMEase
M1S39_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S39_RS00200	COG2814	Major facilitator Superfamily
M1S39_RS00205	COG0656	L-ascorbic acid biosynthetic process
M1S39_RS00210	COG0583	DNA-binding transcription factor activity
M1S39_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S39_RS00230	COG1064	alcohol dehydrogenase
M1S39_RS00235	COG2818	Glycosylase
M1S39_RS00250	COG1194	a g-specific adenine glycosylase
M1S39_RS00270	COG2983	Belongs to the UPF0260 family
M1S39_RS00275	COG2133	pyrroloquinoline quinone binding
M1S39_RS00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M1S39_RS00285	COG2116	formate transmembrane transporter activity
M1S39_RS00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S39_RS00310	COG1335	isochorismatase
M1S39_RS00315	COG0385	Bile acid
M1S39_RS00320	COG0534	Mate efflux family protein
M1S39_RS00325	COG1683	Conserved Protein
M1S39_RS00345	COG0625	glutathione transferase activity
M1S39_RS00355	COG1113	amino acid transport
M1S39_RS00365	COG0523	cobalamin synthesis protein
M1S39_RS00405	COG0010	Belongs to the arginase family
M1S39_RS00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S39_RS00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1S39_RS00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M1S39_RS00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M1S39_RS00540	COG0534	Mate efflux family protein
M1S39_RS00545	COG0436	Aminotransferase
M1S39_RS00550	COG2733	membrane
M1S39_RS00565	COG2918	glutathione biosynthetic process
M1S39_RS00580	COG0791	NLP P60 protein
M1S39_RS00580	COG1388	LysM domain
M1S39_RS00595	COG3150	esterase
M1S39_RS00605	COG1028	Short-chain dehydrogenase reductase Sdr
M1S39_RS00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
M1S39_RS00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S39_RS00630	COG2233	PERMEase
M1S39_RS00635	COG2351	hydroxyisourate hydrolase activity
M1S39_RS00670	COG3706	GGDEF domain
M1S39_RS00685	COG1393	Belongs to the ArsC family
M1S39_RS00690	COG0708	Exodeoxyribonuclease III
M1S39_RS00710	COG0189	ligase activity
M1S39_RS00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M1S39_RS00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M1S39_RS00755	COG4942	peptidase
M1S39_RS00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S39_RS00775	COG2119	membrane
M1S39_RS00795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S39_RS00795	COG0426	domain, Protein
M1S39_RS00820	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M1S39_RS00840	COG1902	pentaerythritol trinitrate reductase activity
M1S39_RS00845	COG1519	Transferase
M1S39_RS00850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S39_RS00855	COG0668	transmembrane transport
M1S39_RS00865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S39_RS00870	COG1335	isochorismatase
M1S39_RS00875	COG1522	sequence-specific DNA binding
M1S39_RS00880	COG3328	transposase activity
M1S39_RS00905	COG0784	Response regulator, receiver
M1S39_RS00905	COG2198	Histidine kinase
M1S39_RS00905	COG2205	protein histidine kinase activity
M1S39_RS00910	COG3162	membrane
M1S39_RS00915	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S39_RS00925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S39_RS00945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M1S39_RS00950	COG1309	transcriptional regulator
M1S39_RS00970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S39_RS00970	COG0352	thiamine-phosphate diphosphorylase activity
M1S39_RS00970	COG0351	phosphomethylpyrimidine kinase
M1S39_RS00980	COG2814	Major facilitator Superfamily
M1S39_RS00995	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S39_RS01005	COG1113	amino acid transport
M1S39_RS01015	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S39_RS01020	COG1012	belongs to the aldehyde dehydrogenase family
M1S39_RS01030	COG1335	isochorismatase
M1S39_RS01060	COG2814	Major facilitator Superfamily
M1S39_RS01065	COG0583	DNA-binding transcription factor activity
M1S39_RS01085	COG0667	Aldo Keto reductase
M1S39_RS01120	COG1733	regulation of RNA biosynthetic process
M1S39_RS01125	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S39_RS01195	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M1S39_RS01210	COG2329	Antibiotic biosynthesis monooxygenase
M1S39_RS01240	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M1S39_RS01270	COG0427	acetyl-CoA hydrolase
M1S39_RS01295	COG0659	secondary active sulfate transmembrane transporter activity
M1S39_RS01300	COG4221	oxidoreductase activity
M1S39_RS01305	COG2873	o-acetylhomoserine
M1S39_RS01310	COG0488	(ABC) transporter
M1S39_RS01395	COG0833	amino acid
M1S39_RS01440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M1S39_RS01445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M1S39_RS01460	COG2226	methyltransferase
M1S39_RS01510	COG0067	glutamate synthase
M1S39_RS01510	COG0069	glutamate synthase activity
M1S39_RS01510	COG0070	glutamate synthase
M1S39_RS01515	COG0493	'glutamate synthase
M1S39_RS01525	COG1704	LemA family
M1S39_RS01530	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M1S39_RS01550	COG3307	-O-antigen
M1S39_RS01570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S39_RS01585	COG0194	GDP metabolic process
M1S39_RS01635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M1S39_RS01655	COG5380	lipid catabolic process
M1S39_RS01660	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M1S39_RS01685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M1S39_RS01690	COG0277	FAD linked oxidase domain protein
M1S39_RS01700	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M1S39_RS01705	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S39_RS01720	COG1289	transmembrane transporter activity
M1S39_RS01730	COG0628	permease
M1S39_RS01735	COG1192	Involved in chromosome partitioning
M1S39_RS01765	COG0833	amino acid
M1S39_RS01770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S39_RS01775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S39_RS01785	COG1012	belongs to the aldehyde dehydrogenase family
M1S39_RS01825	COG0583	DNA-binding transcription factor activity
M1S39_RS01870	COG0517	IMP dehydrogenase activity
M1S39_RS01875	COG1983	PspC domain protein
M1S39_RS01885	COG1960	acyl-CoA dehydrogenase activity
M1S39_RS01900	COG0408	coproporphyrinogen oxidase activity
M1S39_RS01920	COG0513	Belongs to the DEAD box helicase family
M1S39_RS01930	COG1127	ABC transporter
M1S39_RS01935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M1S39_RS01945	COG2854	intermembrane phospholipid transfer
M1S39_RS01955	COG0598	Magnesium transport protein CorA
M1S39_RS01965	COG0494	nUDIX hydrolase
M1S39_RS01970	COG1040	competence protein
M1S39_RS01975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M1S39_RS01995	COG1946	Acyl-CoA thioesterase
M1S39_RS02000	COG1301	dicarboxylic acid transport
M1S39_RS02015	COG1959	2 iron, 2 sulfur cluster binding
M1S39_RS02020	COG1017	nitric oxide dioxygenase activity
M1S39_RS02020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S39_RS02025	COG0433	COG0433 Predicted ATPase
M1S39_RS02030	COG0626	cystathionine gamma-synthase activity
M1S39_RS02185	COG1960	acyl-CoA dehydrogenase activity
M1S39_RS02190	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M1S39_RS02220	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
M1S39_RS02225	COG0339	signal peptide processing
M1S39_RS02230	COG0557	exoribonuclease II activity
M1S39_RS02275	COG0179	Fumarylacetoacetate (FAA) hydrolase
M1S39_RS02280	COG2169	Transcriptional regulator
M1S39_RS02285	COG0697	spore germination
M1S39_RS02290	COG1295	ribonuclease BN
M1S39_RS02325	COG1702	phosphate starvation-inducible protein PhoH
M1S39_RS02335	COG0741	lytic transglycosylase activity
M1S39_RS02335	COG1196	nuclear chromosome segregation
M1S39_RS02335	COG0739	heme binding
M1S39_RS02365	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M1S39_RS02370	COG1183	phosphatidylcholine synthase activity
M1S39_RS02415	COG1960	acyl-CoA dehydrogenase activity
M1S39_RS02420	COG1309	transcriptional regulator
M1S39_RS02435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S39_RS02440	COG1960	acyl-CoA dehydrogenase activity
M1S39_RS02460	COG2969	positive regulation of protein catabolic process
M1S39_RS02470	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M1S39_RS02485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M1S39_RS02490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M1S39_RS02510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M1S39_RS02520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S39_RS02525	COG1408	metallophosphoesterase
M1S39_RS02535	COG2199	diguanylate cyclase activity
M1S39_RS02595	COG1607	acyl-coa hydrolase
M1S39_RS02625	COG2350	Protein conserved in bacteria
M1S39_RS02635	COG0613	PHP domain protein
M1S39_RS02640	COG3781	membrane
M1S39_RS02650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M1S39_RS02655	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1S39_RS02665	COG1862	Preprotein translocase
M1S39_RS02715	COG2205	protein histidine kinase activity
M1S39_RS02720	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M1S39_RS02740	COG0726	polysaccharide deacetylase
M1S39_RS02745	COG0463	Glycosyl transferase, family 2
M1S39_RS02750	COG0438	transferase activity, transferring glycosyl groups
M1S39_RS02815	COG0625	glutathione transferase activity
M1S39_RS02820	COG0583	DNA-binding transcription factor activity
M1S39_RS02825	COG1960	acyl-CoA dehydrogenase activity
M1S39_RS02830	COG1960	acyl-CoA dehydrogenase activity
M1S39_RS02840	COG2205	protein histidine kinase activity
M1S39_RS02845	COG0745	RESPONSE REGULATOR receiver
M1S39_RS02850	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M1S39_RS02870	COG2096	Adenosyltransferase
M1S39_RS02920	COG0285	dihydrofolate synthase activity
M1S39_RS02940	COG0450	alkyl hydroperoxide reductase
M1S39_RS02955	COG0477	Major facilitator Superfamily
M1S39_RS02960	COG1272	protein, Hemolysin III
M1S39_RS02990	COG0183	Belongs to the thiolase family
M1S39_RS02995	COG2207	Transcriptional regulator
M1S39_RS03015	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S39_RS03035	COG0183	Belongs to the thiolase family
M1S39_RS03045	COG2885	chlorophyll binding
M1S39_RS03045	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M1S39_RS03055	COG1690	Belongs to the RtcB family
M1S39_RS03060	COG0833	amino acid
M1S39_RS03070	COG2233	PERMEase
M1S39_RS03075	COG1217	gtp-binding protein TYPA
M1S39_RS03100	COG2094	Belongs to the DNA glycosylase MPG family
M1S39_RS03120	COG1902	pentaerythritol trinitrate reductase activity
M1S39_RS03135	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S39_RS03140	COG0354	folic acid binding
M1S39_RS03150	COG3189	MarR family transcriptional regulator
M1S39_RS03155	COG2824	Alkylphosphonate utilization operon protein PhnA
M1S39_RS03160	COG3422	double-strand break repair
M1S39_RS03200	COG0840	transmembrane signaling receptor activity
M1S39_RS03220	COG5510	response to toxic substance
M1S39_RS03230	COG2832	Protein of unknown function (DUF454)
M1S39_RS03235	COG1376	ErfK ybiS ycfS ynhG family protein
M1S39_RS03275	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M1S39_RS03285	COG1289	transmembrane transporter activity
M1S39_RS03290	COG2814	Major facilitator Superfamily
M1S39_RS03310	COG1115	amino acid carrier protein
M1S39_RS03315	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S39_RS03320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S39_RS03325	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
M1S39_RS03360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S39_RS03370	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S39_RS03375	COG1077	Cell shape determining protein MreB Mrl
M1S39_RS03380	COG1792	Involved in formation and maintenance of cell shape
M1S39_RS03385	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M1S39_RS03390	COG0424	maF-like protein
M1S39_RS03395	COG1530	ribonuclease E activity
M1S39_RS03405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S39_RS03415	COG0560	Phosphoserine phosphatase
M1S39_RS03425	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S39_RS03450	COG2207	Transcriptional regulator
M1S39_RS03470	COG1113	amino acid transport
M1S39_RS03475	COG2828	Protein conserved in bacteria
M1S39_RS03480	COG0142	geranyltranstransferase activity
M1S39_RS03485	COG2315	Protein conserved in bacteria
M1S39_RS03500	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S39_RS03525	COG0745	RESPONSE REGULATOR receiver
M1S39_RS03530	COG0642	Histidine kinase
M1S39_RS03540	COG0004	ammonium transporteR
M1S39_RS03545	COG0583	DNA-binding transcription factor activity
M1S39_RS03565	COG0525	valine-tRNA ligase activity
M1S39_RS03575	COG1028	Short-chain dehydrogenase reductase Sdr
M1S39_RS03585	COG0393	Putative heavy-metal-binding
M1S39_RS03590	COG0393	Putative heavy-metal-binding
M1S39_RS03595	COG1538	Outer membrane efflux protein
M1S39_RS03605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S39_RS03610	COG0671	phosphoesterase, PA-phosphatase related
M1S39_RS03640	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M1S39_RS03655	COG1648	precorrin-2 dehydrogenase activity
M1S39_RS03655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M1S39_RS03660	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M1S39_RS03665	COG1733	regulation of RNA biosynthetic process
M1S39_RS03675	COG0531	amino acid
M1S39_RS03690	COG0321	lipoyl(octanoyl) transferase activity
M1S39_RS03695	COG2921	Belongs to the UPF0250 family
M1S39_RS03735	COG2009	succinate dehydrogenase
M1S39_RS03740	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M1S39_RS03745	COG1053	succinate dehydrogenase
M1S39_RS03750	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M1S39_RS03775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S39_RS03795	COG2354	Protein conserved in bacteria
M1S39_RS03800	COG2321	neutral zinc metallopeptidase
M1S39_RS03835	COG0589	response to stress
M1S39_RS03855	COG0505	Belongs to the CarA family
M1S39_RS03880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S39_RS03885	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M1S39_RS03935	COG0477	Major facilitator Superfamily
M1S39_RS03940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M1S39_RS03955	COG1597	lipid kinase activity
M1S39_RS03960	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S39_RS03985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S39_RS03990	COG0584	glycerophosphoryl diester phosphodiesterase
M1S39_RS04010	COG0741	lytic transglycosylase activity
M1S39_RS04030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M1S39_RS04045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S39_RS04075	COG0778	Nitroreductase
M1S39_RS04090	COG1929	Belongs to the glycerate kinase type-1 family
M1S39_RS04095	COG0243	molybdopterin cofactor binding
M1S39_RS04100	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M1S39_RS04105	COG3339	Conserved Protein
M1S39_RS04115	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M1S39_RS04130	COG1113	amino acid transport
M1S39_RS04140	COG0019	diaminopimelate decarboxylase activity
M1S39_RS04150	COG1280	lysine exporter protein (LysE YggA)
M1S39_RS04155	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S39_RS04185	COG0463	Glycosyl transferase, family 2
M1S39_RS04205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S39_RS04240	COG4591	ABC-type transport system involved in lipoprotein release permease component
M1S39_RS04245	COG1136	(ABC) transporter
M1S39_RS04250	COG2333	competence protein COMEC
M1S39_RS04250	COG0658	competence protein
M1S39_RS04260	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M1S39_RS04260	COG0616	signal peptide processing
M1S39_RS04265	COG0596	Alpha beta hydrolase
M1S39_RS04270	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M1S39_RS04280	COG0628	permease
M1S39_RS04325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S39_RS04345	COG0823	Involved in the tonB-independent uptake of proteins
M1S39_RS04365	COG0824	Thioesterase
M1S39_RS04370	COG1473	amidohydrolase
M1S39_RS04390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M1S39_RS04390	COG0047	phosphoribosylformylglycinamidine synthase activity
M1S39_RS04395	COG2814	Major facilitator Superfamily
M1S39_RS04405	COG1024	Enoyl-CoA hydratase
M1S39_RS04410	COG1051	belongs to the nudix hydrolase family
M1S39_RS04410	COG1056	cytidyltransferase-related domain
M1S39_RS04420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1S39_RS04435	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M1S39_RS04450	COG4625	pathogenesis
M1S39_RS04455	COG0583	DNA-binding transcription factor activity
M1S39_RS04460	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M1S39_RS04465	COG4208	sulfate ABC transporter
M1S39_RS04470	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M1S39_RS04480	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M1S39_RS04485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1S39_RS04490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M1S39_RS04510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S39_RS04525	COG0681	Belongs to the peptidase S26 family
M1S39_RS04540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M1S39_RS04550	COG1381	Involved in DNA repair and RecF pathway recombination
M1S39_RS04555	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M1S39_RS04565	COG4221	oxidoreductase activity
M1S39_RS04595	COG0436	Aminotransferase
M1S39_RS04615	COG0556	nucleotide-excision repair
M1S39_RS04670	COG2070	2-Nitropropane dioxygenase
M1S39_RS04700	COG1215	transferase activity, transferring glycosyl groups
M1S39_RS04715	COG0415	Belongs to the DNA photolyase family
M1S39_RS04725	COG1252	NADH dehydrogenase
M1S39_RS04730	COG1686	Belongs to the peptidase S11 family
M1S39_RS04745	COG1187	pseudouridine synthase activity
M1S39_RS04770	COG0477	Major facilitator Superfamily
M1S39_RS04775	COG0583	DNA-binding transcription factor activity
M1S39_RS04780	COG1823	symporter activity
M1S39_RS04790	COG0612	Peptidase, M16
M1S39_RS04815	COG0352	thiamine-phosphate diphosphorylase activity
M1S39_RS04850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S39_RS04865	COG1309	transcriptional regulator
M1S39_RS04875	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S39_RS04880	COG0076	glutamate decarboxylase activity
M1S39_RS04890	COG1522	sequence-specific DNA binding
M1S39_RS04895	COG3961	Belongs to the TPP enzyme family
M1S39_RS04900	COG1113	amino acid transport
M1S39_RS04905	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S39_RS04910	COG0573	inorganic phosphate transmembrane transporter activity
M1S39_RS04920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M1S39_RS04925	COG0616	signal peptide processing
M1S39_RS04960	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M1S39_RS04965	COG1686	Belongs to the peptidase S11 family
M1S39_RS04990	COG0583	DNA-binding transcription factor activity
M1S39_RS04995	COG1067	ATP-dependent peptidase activity
M1S39_RS05040	COG1966	Carbon starvation protein
M1S39_RS05045	COG2879	small protein
M1S39_RS05080	COG2508	Transcriptional regulator
M1S39_RS05080	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M1S39_RS05100	COG1113	amino acid transport
M1S39_RS05105	COG0583	DNA-binding transcription factor activity
M1S39_RS05110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S39_RS05115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S39_RS05125	COG1012	belongs to the aldehyde dehydrogenase family
M1S39_RS05135	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S39_RS05140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S39_RS05140	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M1S39_RS05175	COG2814	Major facilitator Superfamily
M1S39_RS05180	COG4948	Mandelate Racemase Muconate Lactonizing
M1S39_RS05190	COG1309	transcriptional regulator
M1S39_RS05210	COG1741	Belongs to the pirin family
M1S39_RS05220	COG2964	Protein conserved in bacteria
M1S39_RS05235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S39_RS05240	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S39_RS05245	COG4605	iron ion homeostasis
M1S39_RS05250	COG4604	ABC transporter, ATP-binding protein
M1S39_RS05255	COG4607	ABC-type enterochelin transport system periplasmic component
M1S39_RS05260	COG4774	siderophore transport
M1S39_RS05270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S39_RS05275	COG1021	2,3-dihydroxybenzoate-AMP ligase
M1S39_RS05280	COG1535	isochorismatase
M1S39_RS05280	COG3433	isochorismatase activity
M1S39_RS05295	COG1132	(ABC) transporter
M1S39_RS05300	COG1132	(ABC) transporter
M1S39_RS05305	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M1S39_RS05315	COG1169	isochorismate synthase
M1S39_RS05330	COG3739	integral membrane protein
M1S39_RS05355	COG0302	gtp cyclohydrolase
M1S39_RS05365	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M1S39_RS05395	COG0308	aminopeptidase N
M1S39_RS05400	COG0512	Glutamine amidotransferase of anthranilate synthase
M1S39_RS05415	COG0174	glutamine synthetase
M1S39_RS05425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M1S39_RS05460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1S39_RS05465	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M1S39_RS05470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S39_RS05490	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S39_RS05495	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M1S39_RS05500	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M1S39_RS05515	COG1960	acyl-CoA dehydrogenase activity
M1S39_RS05520	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S39_RS05525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S39_RS05535	COG2223	nitrite transmembrane transporter activity
M1S39_RS05545	COG0024	Methionine aminopeptidase
M1S39_RS05565	COG2207	Transcriptional regulator
M1S39_RS05590	COG2951	lytic endotransglycosylase activity
M1S39_RS05595	COG0772	Belongs to the SEDS family
M1S39_RS05610	COG0842	Transport permease protein
M1S39_RS05615	COG1131	(ABC) transporter
M1S39_RS05660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S39_RS05675	COG4215	(ABC) transporter
M1S39_RS05680	COG4160	amino acid transport
M1S39_RS05685	COG4598	ABC transporter
M1S39_RS05695	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S39_RS05700	COG0826	peptidase U32
M1S39_RS05705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S39_RS05720	COG1720	tRNA m6t6A37 methyltransferase activity
M1S39_RS05730	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M1S39_RS05745	COG0642	Histidine kinase
M1S39_RS05755	COG0494	nUDIX hydrolase
M1S39_RS05765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1S39_RS05770	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M1S39_RS05775	COG3139	Protein of unknown function (DUF1315)
M1S39_RS05780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M1S39_RS05785	COG1301	dicarboxylic acid transport
M1S39_RS05790	COG1960	acyl-CoA dehydrogenase activity
M1S39_RS05795	COG2819	hydrolase of the alpha beta superfamily
M1S39_RS05805	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M1S39_RS05815	COG2195	Cleaves the N-terminal amino acid of tripeptides
M1S39_RS05820	COG1234	tRNA 3'-trailer cleavage
M1S39_RS05850	COG2363	Small membrane protein
M1S39_RS05875	COG0513	Belongs to the DEAD box helicase family
M1S39_RS05885	COG0778	Nitroreductase
M1S39_RS06230	COG1286	toxin biosynthetic process
M1S39_RS06255	COG4783	chaperone-mediated protein folding
M1S39_RS06260	COG1610	YqeY-like protein
M1S39_RS06360	COG3111	PFAM Bacterial OB fold (BOF) protein
M1S39_RS06385	COG3243	poly(R)-hydroxyalkanoic acid synthase
M1S39_RS06390	COG0786	glutamate:sodium symporter activity
M1S39_RS06420	COG1301	dicarboxylic acid transport
M1S39_RS06430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S39_RS06435	COG2011	ABC-type metal ion transport system permease component
M1S39_RS06440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S39_RS06445	COG1464	Belongs to the NlpA lipoprotein family
M1S39_RS06450	COG0151	Belongs to the GarS family
M1S39_RS06455	COG0138	bifunctional purine biosynthesis protein purh
M1S39_RS06460	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M1S39_RS06490	COG2308	Evidence 4 Homologs of previously reported genes of
M1S39_RS06500	COG1305	Transglutaminase-like
M1S39_RS06510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M1S39_RS06515	COG0305	Participates in initiation and elongation during chromosome replication
M1S39_RS06540	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M1S39_RS06550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M1S39_RS06555	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M1S39_RS06580	COG0726	polysaccharide deacetylase
M1S39_RS06580	COG1649	PFAM Uncharacterised BCR, COG1649
M1S39_RS06585	COG1215	transferase activity, transferring glycosyl groups
M1S39_RS06590	COG3658	cytochrome
M1S39_RS06600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S39_RS06615	COG0583	DNA-binding transcription factor activity
M1S39_RS06635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S39_RS06640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S39_RS06655	COG1960	acyl-CoA dehydrogenase activity
M1S39_RS06660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S39_RS06665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S39_RS06690	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M1S39_RS06695	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M1S39_RS06705	COG2205	protein histidine kinase activity
M1S39_RS06710	COG0745	RESPONSE REGULATOR receiver
M1S39_RS06715	COG0174	glutamine synthetase
M1S39_RS06735	COG0729	surface antigen
M1S39_RS06760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S39_RS06765	COG2814	Major facilitator Superfamily
M1S39_RS06780	COG0583	DNA-binding transcription factor activity
M1S39_RS06795	COG1187	pseudouridine synthase activity
M1S39_RS06815	COG0802	atpase or kinase
M1S39_RS06820	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M1S39_RS06830	COG1923	regulation of RNA biosynthetic process
M1S39_RS06835	COG0697	spore germination
M1S39_RS06850	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S39_RS06860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S39_RS06865	COG0519	Catalyzes the synthesis of GMP from XMP
M1S39_RS06865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S39_RS06870	COG4302	ethanolamine ammonia-lyase activity
M1S39_RS06880	COG0531	amino acid
M1S39_RS06900	COG1454	alcohol dehydrogenase
M1S39_RS06905	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S39_RS06915	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M1S39_RS06935	COG0308	aminopeptidase N
M1S39_RS06945	COG4221	oxidoreductase activity
M1S39_RS06955	COG1605	Chorismate mutase
M1S39_RS06975	COG1309	transcriptional regulator
M1S39_RS06985	COG0668	transmembrane transport
M1S39_RS07020	COG4773	Receptor
M1S39_RS07040	COG0488	(ABC) transporter
M1S39_RS07045	COG0589	response to stress
M1S39_RS07070	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M1S39_RS07080	COG3135	benzoate transporter
M1S39_RS07085	COG1522	sequence-specific DNA binding
M1S39_RS07095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M1S39_RS07100	COG0583	DNA-binding transcription factor activity
M1S39_RS07110	COG0183	Belongs to the thiolase family
M1S39_RS07120	COG2030	dehydratase
M1S39_RS07125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S39_RS07140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M1S39_RS07150	COG0824	Thioesterase
M1S39_RS07155	COG1454	alcohol dehydrogenase
M1S39_RS07165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M1S39_RS07185	COG0069	glutamate synthase activity
M1S39_RS07560	COG2814	Major facilitator Superfamily
M1S39_RS07575	COG0511	ligase activity, forming carbon-carbon bonds
M1S39_RS07595	COG1116	anion transmembrane transporter activity
M1S39_RS07595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S39_RS07600	COG0745	RESPONSE REGULATOR receiver
M1S39_RS07610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S39_RS07610	COG2146	nitrite reductase [NAD(P)H] activity
M1S39_RS07615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S39_RS07620	COG0243	molybdopterin cofactor binding
M1S39_RS07630	COG0243	molybdopterin cofactor binding
M1S39_RS07635	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1S39_RS07650	COG0315	cyclic pyranopterin monophosphate synthase activity
M1S39_RS07650	COG0521	Mo-molybdopterin cofactor biosynthetic process
M1S39_RS07655	COG0303	'Molybdopterin
M1S39_RS07665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S39_RS07670	COG0697	spore germination
M1S39_RS07690	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M1S39_RS07695	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S39_RS07760	COG2204	response regulator
M1S39_RS07765	COG3852	Histidine kinase
M1S39_RS07785	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1S39_RS07790	COG0575	Belongs to the CDS family
M1S39_RS07825	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S39_RS07840	COG2137	regulation of response to DNA damage stimulus
M1S39_RS07850	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M1S39_RS07855	COG1011	Hydrolase
M1S39_RS07880	COG1522	sequence-specific DNA binding
M1S39_RS07890	COG1113	amino acid transport
M1S39_RS07910	COG0659	secondary active sulfate transmembrane transporter activity
M1S39_RS07915	COG2135	peptidase activity
M1S39_RS07930	COG3300	MHYT domain
M1S39_RS07930	COG5001	Diguanylate cyclase
M1S39_RS07950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S39_RS07950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S39_RS07950	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M1S39_RS07955	COG1105	Belongs to the carbohydrate kinase PfkB family
M1S39_RS07960	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S39_RS07960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1S39_RS07990	COG0024	Methionine aminopeptidase
M1S39_RS07995	COG0583	DNA-binding transcription factor activity
M1S39_RS08005	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M1S39_RS08010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S39_RS08015	COG0516	GMP reductase activity
M1S39_RS08015	COG0517	IMP dehydrogenase activity
M1S39_RS08040	COG0552	protein localization to endoplasmic reticulum
M1S39_RS08050	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M1S39_RS08065	COG4890	Cyd operon protein YbgT
M1S39_RS08070	COG1294	oxidase, subunit
M1S39_RS08085	COG1585	Membrane protein implicated in regulation of membrane protease activity
M1S39_RS08095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1S39_RS08100	COG4774	siderophore transport
M1S39_RS08115	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1S39_RS08120	COG0569	domain protein
M1S39_RS08125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S39_RS08155	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M1S39_RS08160	COG0542	response to heat
M1S39_RS08185	COG1902	pentaerythritol trinitrate reductase activity
M1S39_RS08185	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S39_RS08230	COG2323	membrane
M1S39_RS08235	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M1S39_RS08245	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S39_RS08250	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S39_RS08255	COG0183	Belongs to the thiolase family
M1S39_RS08260	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M1S39_RS08265	COG0596	Alpha beta hydrolase
M1S39_RS08270	COG2271	Major facilitator Superfamily
M1S39_RS08275	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S39_RS08280	COG3485	protocatechuate 3,4-dioxygenase
M1S39_RS08285	COG3485	protocatechuate 3,4-dioxygenase
M1S39_RS08290	COG0710	3-dehydroquinate dehydratase activity
M1S39_RS08295	COG3420	alginic acid biosynthetic process
M1S39_RS08300	COG3659	wide pore channel activity
M1S39_RS08305	COG4993	Dehydrogenase
M1S39_RS08315	COG2391	methyltransferase activity
M1S39_RS08330	COG1414	Transcriptional regulator
M1S39_RS08335	COG0583	DNA-binding transcription factor activity
M1S39_RS08340	COG1960	acyl-CoA dehydrogenase activity
M1S39_RS08365	COG2814	Major facilitator Superfamily
M1S39_RS08375	COG0154	amidase activity
M1S39_RS08395	COG4638	Rieske (2fe-2S)
M1S39_RS08405	COG1028	Short-chain dehydrogenase reductase Sdr
M1S39_RS08415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S39_RS08425	COG3733	amine oxidase
M1S39_RS08435	COG1012	belongs to the aldehyde dehydrogenase family
M1S39_RS08445	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S39_RS08450	COG0183	Belongs to the thiolase family
M1S39_RS08455	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S39_RS08475	COG4829	muconolactone delta-isomerase
M1S39_RS08480	COG4948	Mandelate Racemase Muconate Lactonizing
M1S39_RS08485	COG0583	DNA-binding transcription factor activity
M1S39_RS08495	COG2186	Transcriptional regulator
M1S39_RS08515	COG1012	belongs to the aldehyde dehydrogenase family
M1S39_RS08535	COG1960	acyl-CoA dehydrogenase activity
M1S39_RS08540	COG1028	Short-chain dehydrogenase reductase Sdr
M1S39_RS08545	COG3829	transcription factor binding
M1S39_RS08555	COG3162	membrane
M1S39_RS08570	COG1012	belongs to the aldehyde dehydrogenase family
M1S39_RS08585	COG0753	catalase activity
M1S39_RS08605	COG1846	Transcriptional regulator
M1S39_RS08610	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S39_RS08610	COG1902	pentaerythritol trinitrate reductase activity
M1S39_RS08620	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M1S39_RS08650	COG1309	transcriptional regulator
M1S39_RS08660	COG1335	isochorismatase
M1S39_RS08665	COG0583	DNA-binding transcription factor activity
M1S39_RS08675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S39_RS08675	COG0475	glutathione-regulated potassium exporter activity
M1S39_RS08685	COG1473	amidohydrolase
M1S39_RS08695	COG2831	hemolysin activation secretion protein
M1S39_RS08700	COG3210	domain, Protein
M1S39_RS08730	COG2188	Transcriptional regulator
M1S39_RS08745	COG0583	DNA-binding transcription factor activity
M1S39_RS08775	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S39_RS08805	COG1566	PFAM secretion protein HlyD family protein
M1S39_RS08820	COG1012	belongs to the aldehyde dehydrogenase family
M1S39_RS08825	COG1012	belongs to the aldehyde dehydrogenase family
M1S39_RS08830	COG0129	dihydroxy-acid dehydratase activity
M1S39_RS08840	COG0583	DNA-binding transcription factor activity
M1S39_RS08845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1S39_RS08855	COG2084	Dehydrogenase
M1S39_RS08860	COG2207	Transcriptional regulator
M1S39_RS08875	COG1064	alcohol dehydrogenase
M1S39_RS08885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S39_RS08890	COG1120	ATPase activity
M1S39_RS08910	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S39_RS09030	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M1S39_RS09080	COG1028	Short-chain dehydrogenase reductase Sdr
M1S39_RS09095	COG2207	Transcriptional regulator
M1S39_RS09105	COG2205	protein histidine kinase activity
M1S39_RS09125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S39_RS09130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S39_RS09135	COG1538	Outer membrane efflux protein
M1S39_RS09145	COG2072	flavoprotein involved in K transport
M1S39_RS09165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S39_RS09185	COG3539	Fimbrial protein
M1S39_RS09215	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M1S39_RS09225	COG0753	catalase activity
M1S39_RS09240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S39_RS09300	COG3433	isochorismatase activity
M1S39_RS09300	COG1535	isochorismatase
M1S39_RS09305	COG1028	Short-chain dehydrogenase reductase Sdr
M1S39_RS09310	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M1S39_RS09315	COG4149	molybdate abc transporter
M1S39_RS09320	COG0725	ABC transporter, periplasmic molybdate-binding protein
M1S39_RS09330	COG4638	Rieske (2fe-2S)
M1S39_RS09335	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S39_RS09340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S39_RS09340	COG0543	2 iron, 2 sulfur cluster binding
M1S39_RS09365	COG1028	Short-chain dehydrogenase reductase Sdr
M1S39_RS09380	COG2207	Transcriptional regulator
M1S39_RS09390	COG1028	Short-chain dehydrogenase reductase Sdr
M1S39_RS09395	COG2610	gluconate transmembrane transporter activity
M1S39_RS09405	COG0583	DNA-binding transcription factor activity
M1S39_RS09415	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S39_RS09420	COG2031	fatty acid transporter
M1S39_RS09425	COG0183	Belongs to the thiolase family
M1S39_RS09430	COG0583	DNA-binding transcription factor activity
M1S39_RS09435	COG0583	DNA-binding transcription factor activity
M1S39_RS09450	COG1027	Aspartate ammonia-lyase
M1S39_RS09460	COG0477	Major facilitator Superfamily
M1S39_RS09480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S39_RS09485	COG4521	taurine ABC transporter
M1S39_RS09500	COG2188	Transcriptional regulator
M1S39_RS09510	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M1S39_RS09515	COG1733	regulation of RNA biosynthetic process
M1S39_RS09520	COG2207	Transcriptional regulator
M1S39_RS09520	COG3708	Transcriptional regulator
M1S39_RS09535	COG0730	response to heat
M1S39_RS09550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S39_RS09550	COG3453	Protein conserved in bacteria
M1S39_RS09560	COG3781	membrane
M1S39_RS09565	COG1063	alcohol dehydrogenase
M1S39_RS09575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S39_RS09580	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S39_RS09585	COG0022	dehydrogenase e1 component
M1S39_RS09590	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1S39_RS09595	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S39_RS09610	COG3706	GGDEF domain
M1S39_RS09625	COG0133	tryptophan synthase activity
M1S39_RS09635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S39_RS09670	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M1S39_RS09695	COG2226	methyltransferase
M1S39_RS09750	COG0842	Transport permease protein
M1S39_RS09755	COG0842	Transport permease protein
M1S39_RS09760	COG1131	(ABC) transporter
M1S39_RS09775	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S39_RS09780	COG4773	Receptor
M1S39_RS09800	COG0730	response to heat
M1S39_RS09805	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M1S39_RS09825	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M1S39_RS09840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S39_RS09880	COG4264	IucA IucC family
M1S39_RS09885	COG4264	IucA IucC family
M1S39_RS09905	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M1S39_RS09920	COG1960	acyl-CoA dehydrogenase activity
M1S39_RS09925	COG1960	acyl-CoA dehydrogenase activity
M1S39_RS09930	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S39_RS09935	COG2207	Transcriptional regulator
M1S39_RS09940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S39_RS09945	COG0776	regulation of translation
M1S39_RS09970	COG0822	iron-sulfur transferase activity
M1S39_RS09975	COG0316	Belongs to the HesB IscA family
M1S39_RS10005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S39_RS10025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S39_RS10030	COG0702	epimerase
M1S39_RS10065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1S39_RS10075	COG0339	signal peptide processing
M1S39_RS10125	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M1S39_RS10130	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M1S39_RS10160	COG0776	regulation of translation
M1S39_RS10225	COG0084	hydrolase, TatD family'
M1S39_RS10245	COG1663	tetraacyldisaccharide 4'-kinase activity
M1S39_RS10250	COG1132	(ABC) transporter
M1S39_RS10260	COG0811	peptide transport
M1S39_RS10265	COG1475	DNA binding
M1S39_RS10270	COG1192	Involved in chromosome partitioning
M1S39_RS10280	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M1S39_RS10295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S39_RS10300	COG0191	fructose-bisphosphate aldolase activity
M1S39_RS10320	COG0424	maF-like protein
M1S39_RS10325	COG2850	peptidyl-arginine hydroxylation
M1S39_RS10335	COG0640	Transcriptional regulator
M1S39_RS10345	COG3619	membrane
M1S39_RS10350	COG3122	Protein conserved in bacteria
M1S39_RS10355	COG1132	(ABC) transporter
M1S39_RS10375	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M1S39_RS10380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S39_RS10390	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S39_RS10390	COG0506	proline dehydrogenase activity
M1S39_RS10390	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S39_RS10395	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M1S39_RS10410	COG3698	Phosphodiester glycosidase
M1S39_RS10420	COG2353	YceI-like domain
M1S39_RS10430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M1S39_RS10480	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M1S39_RS10480	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M1S39_RS10505	COG3539	Fimbrial protein
M1S39_RS10510	COG3121	Chaperone
M1S39_RS10535	COG0697	spore germination
M1S39_RS10545	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S39_RS10555	COG0583	DNA-binding transcription factor activity
M1S39_RS10575	COG1309	transcriptional regulator
M1S39_RS10590	COG1522	sequence-specific DNA binding
M1S39_RS10600	COG1126	abc transporter atp-binding protein
M1S39_RS10605	COG0765	amino acid transport
M1S39_RS10610	COG0765	amino acid transport
M1S39_RS10640	COG1464	Belongs to the NlpA lipoprotein family
M1S39_RS10650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S39_RS10655	COG2011	ABC-type metal ion transport system permease component
M1S39_RS10660	COG0012	GTP binding
M1S39_RS10685	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S39_RS10725	COG0386	Belongs to the glutathione peroxidase family
M1S39_RS10735	COG0436	Aminotransferase
M1S39_RS10780	COG3634	alkyl hydroperoxide reductase activity
M1S39_RS10795	COG0583	DNA-binding transcription factor activity
M1S39_RS10800	COG0798	PFAM Bile acid sodium symporter
M1S39_RS10805	COG0640	Transcriptional regulator
M1S39_RS10820	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M1S39_RS10830	COG0583	DNA-binding transcription factor activity
M1S39_RS10840	COG1953	Uracil, thiamine, allantoin
M1S39_RS10850	COG2175	clavaminate synthase activity
M1S39_RS10855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S39_RS10860	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M1S39_RS10865	COG4521	taurine ABC transporter
M1S39_RS10875	COG0477	Major facilitator Superfamily
M1S39_RS10895	COG1271	oxidase subunit
M1S39_RS10900	COG1294	oxidase, subunit
M1S39_RS10910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S39_RS10930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M1S39_RS10950	COG3052	prosthetic group binding
M1S39_RS10955	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
M1S39_RS10965	COG2814	Major facilitator Superfamily
M1S39_RS10985	COG1346	cytolysis
M1S39_RS10995	COG0583	DNA-binding transcription factor activity
M1S39_RS11000	COG0625	glutathione transferase activity
M1S39_RS11005	COG0625	glutathione transferase activity
M1S39_RS11010	COG0583	DNA-binding transcription factor activity
M1S39_RS11025	COG1045	serine acetyltransferase
M1S39_RS11030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S39_RS11035	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M1S39_RS11045	COG1280	lysine exporter protein (LysE YggA)
M1S39_RS11060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S39_RS11065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S39_RS11070	COG1126	abc transporter atp-binding protein
M1S39_RS11075	COG0765	amino acid transport
M1S39_RS11080	COG0765	amino acid transport
M1S39_RS11100	COG0784	Response regulator, receiver
M1S39_RS11100	COG2205	protein histidine kinase activity
M1S39_RS11120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S39_RS11145	COG1028	Short-chain dehydrogenase reductase Sdr
M1S39_RS11195	COG0583	DNA-binding transcription factor activity
M1S39_RS11215	COG0318	PFAM AMP-dependent synthetase and ligase
M1S39_RS11220	COG1309	transcriptional regulator
M1S39_RS11225	COG1960	acyl-CoA dehydrogenase activity
M1S39_RS11230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S39_RS11235	COG1024	Enoyl-CoA hydratase
M1S39_RS11240	COG4770	biotin carboxylase activity
M1S39_RS11250	COG0583	DNA-binding transcription factor activity
M1S39_RS11265	COG1960	acyl-CoA dehydrogenase activity
M1S39_RS11275	COG2814	Major facilitator Superfamily
M1S39_RS11285	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S39_RS11290	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S39_RS11295	COG2814	Major facilitator Superfamily
M1S39_RS11300	COG1960	acyl-CoA dehydrogenase activity
M1S39_RS11305	COG1024	Enoyl-CoA hydratase
M1S39_RS11310	COG1028	Short-chain dehydrogenase reductase Sdr
M1S39_RS11315	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S39_RS11320	COG0183	Belongs to the thiolase family
M1S39_RS11330	COG2814	Major facilitator Superfamily
M1S39_RS11340	COG1024	Enoyl-CoA hydratase
M1S39_RS11355	COG1960	acyl-CoA dehydrogenase activity
M1S39_RS11360	COG2814	Major facilitator Superfamily
M1S39_RS11365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S39_RS11370	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M1S39_RS11385	COG3842	ATPase activity
M1S39_RS11390	COG1840	ABC-type Fe3 transport system, periplasmic component
M1S39_RS11400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S39_RS11405	COG1414	Transcriptional regulator
M1S39_RS11415	COG0583	DNA-binding transcription factor activity
M1S39_RS11420	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S39_RS11425	COG1012	belongs to the aldehyde dehydrogenase family
M1S39_RS11435	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S39_RS11445	COG1012	belongs to the aldehyde dehydrogenase family
M1S39_RS11450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S39_RS11455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S39_RS11460	COG2267	carboxylic ester hydrolase activity
M1S39_RS11480	COG3038	cytochrome b561
M1S39_RS11485	COG0753	catalase activity
M1S39_RS11520	COG2050	protein possibly involved in aromatic compounds catabolism
M1S39_RS11530	COG3327	negative regulation of DNA-templated transcription, initiation
M1S39_RS11535	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
M1S39_RS11540	COG0183	Belongs to the thiolase family
M1S39_RS11545	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S39_RS11550	COG1024	Enoyl-CoA hydratase
M1S39_RS11555	COG1024	Enoyl-CoA hydratase
M1S39_RS11560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S39_RS11565	COG2151	metal-sulfur cluster biosynthetic enzyme
M1S39_RS11570	COG3396	Phenylacetate-CoA oxygenase
M1S39_RS11575	COG3460	Phenylacetate-CoA oxygenase
M1S39_RS11580	COG3396	Phenylacetate-CoA oxygenase
M1S39_RS11585	COG2030	dehydratase
M1S39_RS11585	COG1012	belongs to the aldehyde dehydrogenase family
M1S39_RS11590	COG1760	l-serine dehydratase
M1S39_RS11595	COG0531	amino acid
M1S39_RS11600	COG1012	belongs to the aldehyde dehydrogenase family
M1S39_RS11615	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S39_RS11625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S39_RS11645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S39_RS11655	COG0789	Transcriptional regulator
M1S39_RS11670	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M1S39_RS11685	COG2807	transmembrane transport
M1S39_RS11690	COG0590	tRNA wobble adenosine to inosine editing
M1S39_RS11810	COG1116	anion transmembrane transporter activity
M1S39_RS11815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S39_RS11825	COG0864	Transcriptional regulator
M1S39_RS11845	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S39_RS11850	COG0439	Biotin carboxylase
M1S39_RS11865	COG1063	alcohol dehydrogenase
M1S39_RS11875	COG1309	transcriptional regulator
M1S39_RS11895	COG0038	chloride channel
M1S39_RS11900	COG4770	biotin carboxylase activity
M1S39_RS11920	COG1914	H( )-stimulated, divalent metal cation uptake system
M1S39_RS11925	COG0583	DNA-binding transcription factor activity
M1S39_RS11960	COG2433	Pfam Transposase IS66
M1S39_RS11990	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S39_RS12010	COG2814	Major facilitator Superfamily
M1S39_RS12025	COG1560	Kdo2-lipid A biosynthetic process
M1S39_RS12035	COG5006	permease, DMT superfamily
M1S39_RS12040	COG1522	sequence-specific DNA binding
M1S39_RS12055	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M1S39_RS12065	COG4122	O-methyltransferase activity
M1S39_RS12095	COG1538	Outer membrane efflux protein
M1S39_RS12100	COG1137	ATPase activity
M1S39_RS12105	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M1S39_RS12115	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M1S39_RS12120	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M1S39_RS12120	COG0517	IMP dehydrogenase activity
M1S39_RS12155	COG2814	Major facilitator Superfamily
M1S39_RS12190	COG1278	Cold shock
M1S39_RS12195	COG1280	lysine exporter protein (LysE YggA)
M1S39_RS12225	COG1570	exodeoxyribonuclease VII activity
M1S39_RS12275	COG0583	DNA-binding transcription factor activity
M1S39_RS12285	COG4638	Rieske (2fe-2S)
M1S39_RS12290	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S39_RS12295	COG0543	2 iron, 2 sulfur cluster binding
M1S39_RS12295	COG0633	Ferredoxin
M1S39_RS12300	COG1028	Short-chain dehydrogenase reductase Sdr
M1S39_RS12305	COG3135	benzoate transporter
M1S39_RS12310	COG2814	Major facilitator Superfamily
M1S39_RS12325	COG1643	Atp-dependent helicase
M1S39_RS12330	COG0450	alkyl hydroperoxide reductase
M1S39_RS12340	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M1S39_RS12370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M1S39_RS12375	COG0625	glutathione transferase activity
M1S39_RS12385	COG2885	chlorophyll binding
M1S39_RS12420	COG0542	response to heat
M1S39_RS12435	COG1765	OsmC-like protein
M1S39_RS12455	COG0667	Aldo Keto reductase
M1S39_RS12470	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M1S39_RS12480	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M1S39_RS12490	COG0527	aspartate kinase activity
M1S39_RS12500	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M1S39_RS12510	COG3038	cytochrome b561
M1S39_RS12515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M1S39_RS12520	COG2252	PERMEase
M1S39_RS12530	COG2072	flavoprotein involved in K transport
M1S39_RS12545	COG1741	Belongs to the pirin family
M1S39_RS12550	COG1309	transcriptional regulator
M1S39_RS12560	COG0300	oxidoreductase activity
M1S39_RS12590	COG0531	amino acid
M1S39_RS12600	COG1113	amino acid transport
M1S39_RS12640	COG3209	COG3209 Rhs family protein
M1S39_RS12670	COG4269	membrane
M1S39_RS12685	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S39_RS12685	COG1902	pentaerythritol trinitrate reductase activity
M1S39_RS12695	COG2203	Gaf domain
M1S39_RS12695	COG5001	Diguanylate cyclase
M1S39_RS12695	COG4251	negative regulation of phosphorylation
M1S39_RS12695	COG3706	GGDEF domain
M1S39_RS12705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S39_RS12725	COG4172	Belongs to the ABC transporter superfamily
M1S39_RS12730	COG4239	(ABC) transporter, permease
M1S39_RS12735	COG4174	ABC transporter (Permease)
M1S39_RS12745	COG0741	lytic transglycosylase activity
M1S39_RS12745	COG1388	LysM domain
M1S39_RS12745	COG0741	lytic transglycosylase activity
M1S39_RS12745	COG1388	LysM domain
M1S39_RS12750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S39_RS12790	COG0583	DNA-binding transcription factor activity
M1S39_RS12795	COG1279	arginine transmembrane transporter activity
M1S39_RS12815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S39_RS12820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S39_RS12825	COG0006	proline dipeptidase activity
M1S39_RS12910	COG0739	heme binding
M1S39_RS13235	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M1S39_RS13260	COG3384	dioxygenase
M1S39_RS13270	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S39_RS13275	COG2878	Part of a membrane complex involved in electron transport
M1S39_RS13280	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M1S39_RS13305	COG0768	penicillin binding
M1S39_RS13310	COG0742	ribosomal rna small subunit methyltransferase
M1S39_RS13325	COG0830	nickel cation binding
M1S39_RS13335	COG0804	urea catabolic process
M1S39_RS13375	COG1253	flavin adenine dinucleotide binding
M1S39_RS13380	COG2851	Citrate transporter
M1S39_RS13430	COG1773	rubredoxin
M1S39_RS13435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S39_RS13445	COG0583	DNA-binding transcription factor activity
M1S39_RS13470	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M1S39_RS13475	COG4181	ATPase activity
M1S39_RS13520	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M1S39_RS13540	COG0306	phosphate transporter
M1S39_RS13550	COG3958	Transketolase
M1S39_RS13555	COG3959	Transketolase, thiamine diphosphate binding domain
M1S39_RS13560	COG2271	Major facilitator Superfamily
M1S39_RS13565	COG1028	Short-chain dehydrogenase reductase Sdr
M1S39_RS13570	COG0583	DNA-binding transcription factor activity
M1S39_RS13585	COG2223	nitrite transmembrane transporter activity
M1S39_RS13590	COG2207	Transcriptional regulator
M1S39_RS13595	COG2066	Belongs to the glutaminase family
M1S39_RS13600	COG0242	peptide deformylase activity
M1S39_RS13605	COG0477	Major facilitator Superfamily
M1S39_RS13615	COG0028	Belongs to the TPP enzyme family
M1S39_RS13630	COG1028	Short-chain dehydrogenase reductase Sdr
M1S39_RS13635	COG2267	carboxylic ester hydrolase activity
M1S39_RS13645	COG2271	Major facilitator Superfamily
M1S39_RS13650	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S39_RS13660	COG1028	Short-chain dehydrogenase reductase Sdr
M1S39_RS13680	COG1414	Transcriptional regulator
M1S39_RS13695	COG1024	Enoyl-CoA hydratase
M1S39_RS13705	COG1215	transferase activity, transferring glycosyl groups
M1S39_RS13710	COG0726	polysaccharide deacetylase
M1S39_RS13710	COG1649	PFAM Uncharacterised BCR, COG1649
M1S39_RS13720	COG4681	YaeQ
M1S39_RS13730	COG0523	cobalamin synthesis protein
M1S39_RS13740	COG1607	acyl-coa hydrolase
M1S39_RS13750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S39_RS13755	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S39_RS13760	COG1309	transcriptional regulator
M1S39_RS13785	COG2040	homocysteine
M1S39_RS13790	COG0531	amino acid
M1S39_RS13815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S39_RS13820	COG0477	Major facilitator Superfamily
M1S39_RS13880	COG1061	Type III restriction enzyme res subunit
M1S39_RS13890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S39_RS13895	COG1192	Involved in chromosome partitioning
M1S39_RS13905	COG1061	Type III restriction enzyme res subunit
M1S39_RS14000	COG0592	DNA-directed DNA polymerase activity
M1S39_RS14040	COG2026	Addiction module toxin, RelE StbE family
M1S39_RS14190	COG3755	Protein conserved in bacteria
M1S39_RS14235	COG1484	DNA-dependent DNA replication
M1S39_RS14325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S39_RS14395	COG0405	Gamma-glutamyltransferase
M1S39_RS14400	COG2814	Major facilitator Superfamily
M1S39_RS14410	COG2050	protein possibly involved in aromatic compounds catabolism
M1S39_RS14425	COG1090	epimerase
M1S39_RS14445	COG0420	3'-5' exonuclease activity
M1S39_RS14470	COG0735	belongs to the Fur family
M1S39_RS14475	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M1S39_RS14495	COG0121	glutamine amidotransferase
M1S39_RS14510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S39_RS14520	COG0210	DNA helicase
M1S39_RS14525	COG2885	chlorophyll binding
M1S39_RS14530	COG0204	Acyl-transferase
M1S39_RS14545	COG2894	cell division
M1S39_RS14570	COG1280	lysine exporter protein (LysE YggA)
M1S39_RS14575	COG1674	ftsk spoiiie
M1S39_RS14575	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M1S39_RS14580	COG0492	ferredoxin-NADP+ reductase activity
M1S39_RS14585	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M1S39_RS14595	COG0456	acetyltransferase
M1S39_RS14640	COG1981	membrane
M1S39_RS14655	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M1S39_RS14655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S39_RS14675	COG1012	belongs to the aldehyde dehydrogenase family
M1S39_RS14685	COG0657	acetylesterase activity
M1S39_RS14695	COG0473	3-isopropylmalate dehydrogenase activity
M1S39_RS14700	COG0583	DNA-binding transcription factor activity
M1S39_RS14720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S39_RS14745	COG0564	pseudouridine synthase activity
M1S39_RS14755	COG0358	DNA primase activity
M1S39_RS14770	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M1S39_RS14800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S39_RS14830	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M1S39_RS14840	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S39_RS14840	COG0352	thiamine-phosphate diphosphorylase activity
M1S39_RS14840	COG0351	phosphomethylpyrimidine kinase
M1S39_RS14845	COG1652	LysM domain
M1S39_RS14870	COG1399	metal-binding, possibly nucleic acid-binding protein
M1S39_RS14875	COG3101	peptidyl-lysine hydroxylation
M1S39_RS14880	COG0009	L-threonylcarbamoyladenylate synthase
M1S39_RS14885	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M1S39_RS14890	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M1S39_RS14905	COG4106	trans-aconitate 2-methyltransferase activity
M1S39_RS14920	COG0596	Alpha beta hydrolase
M1S39_RS14920	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S39_RS14920	COG2226	methyltransferase
M1S39_RS14925	COG1877	trehalose-phosphatase activity
M1S39_RS14930	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
M1S39_RS14935	COG2223	nitrite transmembrane transporter activity
M1S39_RS14955	COG1196	nuclear chromosome segregation
M1S39_RS14965	COG0730	response to heat
M1S39_RS14980	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M1S39_RS14990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S39_RS15040	COG0489	protein tyrosine kinase activity
M1S39_RS15050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S39_RS15050	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S39_RS15080	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M1S39_RS15085	COG2081	HI0933 family
M1S39_RS15095	COG0668	transmembrane transport
M1S39_RS15115	COG0583	DNA-binding transcription factor activity
M1S39_RS15135	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1S39_RS15140	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S39_RS15170	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M1S39_RS15210	COG0745	RESPONSE REGULATOR receiver
M1S39_RS15230	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S39_RS15240	COG2205	protein histidine kinase activity
M1S39_RS15310	COG4993	Dehydrogenase
M1S39_RS15335	COG0384	phenazine biosynthesis protein PhzF
M1S39_RS15360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S39_RS15375	COG0583	DNA-binding transcription factor activity
M1S39_RS15405	COG0583	DNA-binding transcription factor activity
M1S39_RS15420	COG0583	DNA-binding transcription factor activity
M1S39_RS15425	COG1053	succinate dehydrogenase
M1S39_RS15435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M1S39_RS15440	COG2814	Major facilitator Superfamily
M1S39_RS15445	COG1960	acyl-CoA dehydrogenase activity
M1S39_RS15450	COG0583	DNA-binding transcription factor activity
M1S39_RS15455	COG1063	alcohol dehydrogenase
M1S39_RS15485	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M1S39_RS15490	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M1S39_RS15495	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S39_RS15510	COG3667	copper resistance
M1S39_RS15515	COG2132	Multicopper oxidase
M1S39_RS15525	COG0561	phosphatase activity
M1S39_RS15530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M1S39_RS15555	COG1214	PFAM Peptidase M22, glycoprotease
M1S39_RS15605	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M1S39_RS15615	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M1S39_RS15620	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M1S39_RS15625	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M1S39_RS15685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S39_RS15695	COG1846	Transcriptional regulator
M1S39_RS15700	COG1764	response to oxidative stress
M1S39_RS15740	COG0037	tRNA processing
M1S39_RS15750	COG0248	Ppx GppA phosphatase
M1S39_RS15780	COG0072	phenylalanine-tRNA ligase activity
M1S39_RS15825	COG1238	metal cluster binding
M1S39_RS15830	COG0625	glutathione transferase activity
M1S39_RS15845	COG0318	PFAM AMP-dependent synthetase and ligase
M1S39_RS15850	COG3028	Belongs to the UPF0307 family
M1S39_RS15855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S39_RS15875	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M1S39_RS15880	COG0617	tRNA 3'-terminal CCA addition
M1S39_RS15885	COG1555	photosystem II stabilization
M1S39_RS15890	COG3956	TIGRFAM MazG family protein
M1S39_RS15900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S39_RS15920	COG0784	Response regulator, receiver
M1S39_RS15920	COG2205	protein histidine kinase activity
M1S39_RS15920	COG5002	protein histidine kinase activity
M1S39_RS15925	COG1024	Enoyl-CoA hydratase
M1S39_RS15930	COG2084	Dehydrogenase
M1S39_RS15935	COG3622	Belongs to the hyi family
M1S39_RS15965	COG0697	spore germination
M1S39_RS15975	COG2814	Major facilitator Superfamily
M1S39_RS15980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S39_RS15990	COG0583	DNA-binding transcription factor activity
M1S39_RS16000	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M1S39_RS16015	COG0084	hydrolase, TatD family'
M1S39_RS16030	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M1S39_RS16060	COG0440	acetolactate synthase activity
M1S39_RS16065	COG0028	Belongs to the TPP enzyme family
M1S39_RS16090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S39_RS16095	COG1136	(ABC) transporter
M1S39_RS16095	COG0577	efflux transmembrane transporter activity
M1S39_RS16100	COG1538	Outer membrane efflux protein
M1S39_RS16115	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M1S39_RS16120	COG1162	GTPase activity
M1S39_RS16130	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M1S39_RS16150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M1S39_RS16155	COG1028	Short-chain dehydrogenase reductase Sdr
M1S39_RS16195	COG2986	histidine ammonia-lyase
M1S39_RS16210	COG0318	PFAM AMP-dependent synthetase and ligase
M1S39_RS16220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S39_RS16265	COG1426	Protein conserved in bacteria
M1S39_RS16300	COG0793	Belongs to the peptidase S41A family
M1S39_RS16315	COG2267	carboxylic ester hydrolase activity
M1S39_RS16325	COG1012	belongs to the aldehyde dehydrogenase family
M1S39_RS16330	COG3265	gluconokinase activity
M1S39_RS16340	COG0800	Aldolase
M1S39_RS16350	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M1S39_RS16355	COG0857	belongs to the CobB CobQ family
M1S39_RS16355	COG0280	phosphate acetyltransferase
M1S39_RS16360	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S39_RS16360	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S39_RS16380	COG0740	serine-type endopeptidase activity
M1S39_RS16390	COG4774	siderophore transport
M1S39_RS16400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1S39_RS16410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S39_RS16410	COG2813	Specifically methylates the guanine in position
M1S39_RS16510	COG0788	formyltetrahydrofolate deformylase activity
M1S39_RS16535	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S39_RS16535	COG4651	solute:proton antiporter activity
M1S39_RS16555	COG0724	RNA recognition motif
M1S39_RS16560	COG0210	DNA helicase
M1S39_RS16585	COG1733	regulation of RNA biosynthetic process
M1S39_RS16595	COG2900	Belongs to the SlyX family
M1S39_RS16600	COG0488	(ABC) transporter
M1S39_RS16605	COG1280	lysine exporter protein (LysE YggA)
M1S39_RS16610	COG1560	Kdo2-lipid A biosynthetic process
M1S39_RS16620	COG1301	dicarboxylic acid transport
M1S39_RS16675	COG0473	3-isopropylmalate dehydrogenase activity
M1S39_RS16740	COG0583	DNA-binding transcription factor activity
M1S39_RS16750	COG0625	glutathione transferase activity
M1S39_RS16755	COG2378	regulation of single-species biofilm formation
M1S39_RS16760	COG0546	phosphoglycolate phosphatase activity
M1S39_RS16770	COG1530	ribonuclease E activity
M1S39_RS16775	COG0318	PFAM AMP-dependent synthetase and ligase
M1S39_RS16790	COG0583	DNA-binding transcription factor activity
M1S39_RS16795	COG4221	oxidoreductase activity
M1S39_RS16800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M1S39_RS16810	COG0534	Mate efflux family protein
M1S39_RS16825	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M1S39_RS16865	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M1S39_RS16870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S39_RS16885	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S39_RS16895	COG0644	oxidoreductase
M1S39_RS16895	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
M1S39_RS16900	COG0425	Belongs to the sulfur carrier protein TusA family
M1S39_RS16905	COG4535	Mg2 and Co2 transporter CorC
M1S39_RS16915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S39_RS16935	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M1S39_RS16940	COG0475	glutathione-regulated potassium exporter activity
M1S39_RS16940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S39_RS16945	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M1S39_RS16955	COG0484	heat shock protein binding
M1S39_RS16960	COG0789	Transcriptional regulator
M1S39_RS16965	COG0598	Magnesium transport protein CorA
M1S39_RS16980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S39_RS16985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S39_RS16990	COG1074	ATP-dependent DNA helicase activity
M1S39_RS16995	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M1S39_RS17015	COG2226	methyltransferase
M1S39_RS17030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S39_RS17035	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M1S39_RS17050	COG2111	Na H antiporter
M1S39_RS17050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S39_RS17055	COG1006	Multisubunit Na H antiporter MnhC subunit
M1S39_RS17060	COG0651	ATP synthesis coupled electron transport
M1S39_RS17065	COG1863	multisubunit Na H antiporter MnhE subunit
M1S39_RS17070	COG2212	antiporter activity
M1S39_RS17075	COG1320	monovalent cation:proton antiporter activity
M1S39_RS17090	COG0195	Participates in both transcription termination and antitermination
M1S39_RS17140	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M1S39_RS17145	COG0237	dephospho-CoA kinase activity
M1S39_RS17155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S39_RS17170	COG0497	DNA recombination
M1S39_RS17180	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M1S39_RS17210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S39_RS17210	COG2169	Transcriptional regulator
M1S39_RS17215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M1S39_RS17280	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M1S39_RS17295	COG0326	Molecular chaperone. Has ATPase activity
M1S39_RS17310	COG2056	Na+-H+ antiporter family
M1S39_RS17315	COG0596	Alpha beta hydrolase
M1S39_RS17410	COG0546	phosphoglycolate phosphatase activity
M1S39_RS17415	COG1716	ATPase activity
M1S39_RS17460	COG0181	hydroxymethylbilane synthase activity
M1S39_RS17470	COG3275	phosphorelay sensor kinase activity
M1S39_RS17490	COG1538	Outer membrane efflux protein
M1S39_RS17495	COG0697	spore germination
M1S39_RS17520	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S39_RS17525	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M1S39_RS17530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S39_RS17535	COG0772	Belongs to the SEDS family
M1S39_RS17560	COG4974	Belongs to the 'phage' integrase family
M1S39_RS17565	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S39_RS17575	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M1S39_RS17585	COG2197	response regulator
M1S39_RS17600	COG0793	Belongs to the peptidase S41A family
M1S39_RS17605	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M1S39_RS17610	COG0795	lipopolysaccharide-transporting ATPase activity
M1S39_RS17650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S39_RS17650	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S39_RS17660	COG0004	ammonium transporteR
M1S39_RS17665	COG0347	Belongs to the P(II) protein family
M1S39_RS17725	COG0659	secondary active sulfate transmembrane transporter activity
M1S39_RS17760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S39_RS17805	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S39_RS17885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S39_RS17895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S39_RS17915	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M1S39_RS17930	COG0318	PFAM AMP-dependent synthetase and ligase
M1S39_RS17940	COG0477	Major facilitator Superfamily
M1S39_RS17945	COG2860	membrane
M1S39_RS17955	COG1253	flavin adenine dinucleotide binding
M1S39_RS17975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1S39_RS18015	COG0655	NAD(P)H dehydrogenase (quinone) activity
M1S39_RS18025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M1S39_RS18095	COG0758	DNA mediated transformation
M1S39_RS18105	COG0697	spore germination
M1S39_RS18110	COG1309	transcriptional regulator
M1S39_RS18125	COG0386	Belongs to the glutathione peroxidase family
M1S39_RS18190	COG1121	(ABC) transporter
M1S39_RS18195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1S39_RS18200	COG1280	lysine exporter protein (LysE YggA)
M1S39_RS18205	COG2837	iron assimilation
M1S39_RS18215	COG0281	malic enzyme
M1S39_RS18260	COG0519	Catalyzes the synthesis of GMP from XMP
M1S39_RS18260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S39_RS18265	COG4399	Belongs to the UPF0754 family
M1S39_RS18270	COG2259	Doxx family
M1S39_RS18275	COG0586	Pfam SNARE associated Golgi protein
M1S39_RS18290	COG1192	Involved in chromosome partitioning
M1S39_RS18300	COG0271	Belongs to the BolA IbaG family
M1S39_RS18320	COG2267	carboxylic ester hydrolase activity
M1S39_RS18340	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M1S39_RS18340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M1S39_RS18340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S39_RS18340	COG3321	synthase
M1S39_RS18345	COG1960	acyl-CoA dehydrogenase activity
M1S39_RS18355	COG2197	response regulator
M1S39_RS18365	COG3916	Acyl-homoserine-lactone synthase
M1S39_RS18370	COG0477	Major facilitator Superfamily
M1S39_RS18375	COG1024	Enoyl-CoA hydratase
M1S39_RS18380	COG1024	Enoyl-CoA hydratase
M1S39_RS18385	COG1960	acyl-CoA dehydrogenase activity
M1S39_RS18390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S39_RS18410	COG1113	amino acid transport
M1S39_RS18415	COG1113	amino acid transport
M1S39_RS18420	COG0251	oxidation-reduction process
M1S39_RS18460	COG0564	pseudouridine synthase activity
M1S39_RS18520	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M1S39_RS18535	COG1802	Transcriptional regulator
M1S39_RS18545	COG1448	Aminotransferase
M1S39_RS18550	COG0277	FAD linked oxidase domain protein
M1S39_RS18560	COG2186	Transcriptional regulator
M1S39_RS18570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S39_RS18575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S39_RS18590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M1S39_RS18595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M1S39_RS18600	COG1216	Glycosyl transferase, family 2
M1S39_RS18630	COG2089	acid synthase
M1S39_RS18645	COG1083	cytidylyl-transferase
M1S39_RS18650	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M1S39_RS18655	COG1086	Polysaccharide biosynthesis protein
M1S39_RS18660	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M1S39_RS18665	COG1596	polysaccharide export
M1S39_RS18690	COG0728	peptidoglycan biosynthetic process
M1S39_RS18695	COG3023	N-Acetylmuramoyl-L-alanine amidase
M1S39_RS18755	COG0546	phosphoglycolate phosphatase activity
M1S39_RS18760	COG1028	Short-chain dehydrogenase reductase Sdr
M1S39_RS18780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S39_RS18785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S39_RS18790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S39_RS18795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S39_RS18800	COG1116	anion transmembrane transporter activity
M1S39_RS18805	COG1309	transcriptional regulator
M1S39_RS18810	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M1S39_RS18820	COG0196	riboflavin kinase activity
M1S39_RS18825	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M1S39_RS18835	COG1047	Peptidyl-prolyl cis-trans
M1S39_RS18875	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M1S39_RS18880	COG0657	acetylesterase activity
M1S39_RS18900	COG0583	DNA-binding transcription factor activity
M1S39_RS18930	COG2951	lytic endotransglycosylase activity
M1S39_RS18935	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M1S39_RS18950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M1S39_RS18960	COG0671	phosphoesterase, PA-phosphatase related
M1S39_RS18965	COG0861	Integral membrane protein TerC family
M1S39_RS18975	COG0754	glutathionylspermidine amidase activity
M1S39_RS18985	COG0402	S-adenosylhomocysteine deaminase activity
M1S39_RS19000	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S39_RS19005	COG1230	cation diffusion facilitator family transporter
M1S39_RS19020	COG0706	membrane insertase activity
M1S39_RS19045	COG1475	DNA binding
M1S39_RS19060	COG3853	Toxic anion resistance protein (TelA)
M1S39_RS19255	COG0741	lytic transglycosylase activity
M1S39_RS19290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S39_RS19460	COG1525	nuclease