locus-tag	class	description
M1S43_RS00010	COG0592	DNA-directed DNA polymerase activity
M1S43_RS00020	COG0187	DNA topoisomerase II activity
M1S43_RS00045	COG0488	(ABC) transporter
M1S43_RS00070	COG0596	Alpha beta hydrolase
M1S43_RS00075	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M1S43_RS00080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M1S43_RS00120	COG0733	neurotransmitter:sodium symporter activity
M1S43_RS00160	COG2233	PERMEase
M1S43_RS00175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S43_RS00210	COG2814	Major facilitator Superfamily
M1S43_RS00215	COG0656	L-ascorbic acid biosynthetic process
M1S43_RS00220	COG0583	DNA-binding transcription factor activity
M1S43_RS00235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S43_RS00240	COG1064	alcohol dehydrogenase
M1S43_RS00245	COG2818	Glycosylase
M1S43_RS00260	COG1194	a g-specific adenine glycosylase
M1S43_RS00280	COG2983	Belongs to the UPF0260 family
M1S43_RS00285	COG2133	pyrroloquinoline quinone binding
M1S43_RS00290	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M1S43_RS00295	COG2116	formate transmembrane transporter activity
M1S43_RS00315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S43_RS00320	COG1335	isochorismatase
M1S43_RS00325	COG0385	Bile acid
M1S43_RS00330	COG0534	Mate efflux family protein
M1S43_RS00335	COG1683	Conserved Protein
M1S43_RS00355	COG0625	glutathione transferase activity
M1S43_RS00365	COG1113	amino acid transport
M1S43_RS00375	COG0523	cobalamin synthesis protein
M1S43_RS00385	COG2188	Transcriptional regulator
M1S43_RS00415	COG0010	Belongs to the arginase family
M1S43_RS00430	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S43_RS00435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1S43_RS00445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M1S43_RS00450	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M1S43_RS00550	COG0534	Mate efflux family protein
M1S43_RS00555	COG0436	Aminotransferase
M1S43_RS00560	COG2733	membrane
M1S43_RS00575	COG2918	glutathione biosynthetic process
M1S43_RS00590	COG1388	LysM domain
M1S43_RS00590	COG0791	NLP P60 protein
M1S43_RS00605	COG3150	esterase
M1S43_RS00615	COG1028	Short-chain dehydrogenase reductase Sdr
M1S43_RS00620	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
M1S43_RS00630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S43_RS00640	COG2233	PERMEase
M1S43_RS00645	COG2351	hydroxyisourate hydrolase activity
M1S43_RS00680	COG3706	GGDEF domain
M1S43_RS00695	COG1393	Belongs to the ArsC family
M1S43_RS00700	COG0708	Exodeoxyribonuclease III
M1S43_RS00720	COG0189	ligase activity
M1S43_RS00740	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M1S43_RS00750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M1S43_RS00765	COG4942	peptidase
M1S43_RS00775	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S43_RS00785	COG2119	membrane
M1S43_RS00805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S43_RS00805	COG0426	domain, Protein
M1S43_RS00830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M1S43_RS00850	COG1902	pentaerythritol trinitrate reductase activity
M1S43_RS00855	COG1519	Transferase
M1S43_RS00860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S43_RS00865	COG0668	transmembrane transport
M1S43_RS00875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S43_RS00880	COG1335	isochorismatase
M1S43_RS00885	COG1522	sequence-specific DNA binding
M1S43_RS00890	COG3328	transposase activity
M1S43_RS00920	COG2198	Histidine kinase
M1S43_RS00920	COG0784	Response regulator, receiver
M1S43_RS00920	COG2205	protein histidine kinase activity
M1S43_RS00925	COG3162	membrane
M1S43_RS00930	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S43_RS00940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S43_RS00960	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M1S43_RS00965	COG1309	transcriptional regulator
M1S43_RS00985	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S43_RS00985	COG0352	thiamine-phosphate diphosphorylase activity
M1S43_RS00985	COG0351	phosphomethylpyrimidine kinase
M1S43_RS00995	COG2814	Major facilitator Superfamily
M1S43_RS01010	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S43_RS01020	COG1113	amino acid transport
M1S43_RS01030	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S43_RS01045	COG1335	isochorismatase
M1S43_RS01075	COG2814	Major facilitator Superfamily
M1S43_RS01080	COG0583	DNA-binding transcription factor activity
M1S43_RS01100	COG0667	Aldo Keto reductase
M1S43_RS01135	COG1733	regulation of RNA biosynthetic process
M1S43_RS01140	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S43_RS01205	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M1S43_RS01225	COG2329	Antibiotic biosynthesis monooxygenase
M1S43_RS01255	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M1S43_RS01285	COG0427	acetyl-CoA hydrolase
M1S43_RS01310	COG0659	secondary active sulfate transmembrane transporter activity
M1S43_RS01315	COG4221	oxidoreductase activity
M1S43_RS01320	COG2873	o-acetylhomoserine
M1S43_RS01325	COG0488	(ABC) transporter
M1S43_RS01410	COG0833	amino acid
M1S43_RS01455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M1S43_RS01460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M1S43_RS01475	COG2226	methyltransferase
M1S43_RS01525	COG0067	glutamate synthase
M1S43_RS01525	COG0069	glutamate synthase activity
M1S43_RS01525	COG0070	glutamate synthase
M1S43_RS01530	COG0493	'glutamate synthase
M1S43_RS01540	COG1704	LemA family
M1S43_RS01545	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M1S43_RS01565	COG3307	-O-antigen
M1S43_RS01585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S43_RS01600	COG0194	GDP metabolic process
M1S43_RS01650	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M1S43_RS01670	COG5380	lipid catabolic process
M1S43_RS01675	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M1S43_RS01700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M1S43_RS01705	COG0277	FAD linked oxidase domain protein
M1S43_RS01715	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M1S43_RS01720	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S43_RS01735	COG1289	transmembrane transporter activity
M1S43_RS01745	COG0628	permease
M1S43_RS01750	COG1192	Involved in chromosome partitioning
M1S43_RS01780	COG0833	amino acid
M1S43_RS01785	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S43_RS01790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S43_RS01800	COG1012	belongs to the aldehyde dehydrogenase family
M1S43_RS01840	COG0583	DNA-binding transcription factor activity
M1S43_RS01885	COG0517	IMP dehydrogenase activity
M1S43_RS01890	COG1983	PspC domain protein
M1S43_RS01900	COG1960	acyl-CoA dehydrogenase activity
M1S43_RS01915	COG0408	coproporphyrinogen oxidase activity
M1S43_RS01935	COG0513	Belongs to the DEAD box helicase family
M1S43_RS01945	COG1127	ABC transporter
M1S43_RS01950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M1S43_RS01960	COG2854	intermembrane phospholipid transfer
M1S43_RS01970	COG0598	Magnesium transport protein CorA
M1S43_RS01980	COG0494	nUDIX hydrolase
M1S43_RS01985	COG1040	competence protein
M1S43_RS01990	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M1S43_RS02010	COG1946	Acyl-CoA thioesterase
M1S43_RS02015	COG1301	dicarboxylic acid transport
M1S43_RS02030	COG1959	2 iron, 2 sulfur cluster binding
M1S43_RS02035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S43_RS02035	COG1017	nitric oxide dioxygenase activity
M1S43_RS02040	COG0433	COG0433 Predicted ATPase
M1S43_RS02045	COG0626	cystathionine gamma-synthase activity
M1S43_RS02200	COG1960	acyl-CoA dehydrogenase activity
M1S43_RS02205	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M1S43_RS02235	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
M1S43_RS02240	COG0339	signal peptide processing
M1S43_RS02245	COG0557	exoribonuclease II activity
M1S43_RS02290	COG0179	Fumarylacetoacetate (FAA) hydrolase
M1S43_RS02295	COG2169	Transcriptional regulator
M1S43_RS02300	COG0697	spore germination
M1S43_RS02305	COG1295	ribonuclease BN
M1S43_RS02340	COG1702	phosphate starvation-inducible protein PhoH
M1S43_RS02350	COG0739	heme binding
M1S43_RS02350	COG0741	lytic transglycosylase activity
M1S43_RS02350	COG1196	nuclear chromosome segregation
M1S43_RS02380	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M1S43_RS02385	COG1183	phosphatidylcholine synthase activity
M1S43_RS02430	COG1960	acyl-CoA dehydrogenase activity
M1S43_RS02435	COG1309	transcriptional regulator
M1S43_RS02450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S43_RS02455	COG1960	acyl-CoA dehydrogenase activity
M1S43_RS02475	COG2969	positive regulation of protein catabolic process
M1S43_RS02485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M1S43_RS02500	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M1S43_RS02505	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M1S43_RS02525	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M1S43_RS02535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S43_RS02540	COG1408	metallophosphoesterase
M1S43_RS02550	COG2199	diguanylate cyclase activity
M1S43_RS02610	COG1607	acyl-coa hydrolase
M1S43_RS02640	COG2350	Protein conserved in bacteria
M1S43_RS02650	COG0613	PHP domain protein
M1S43_RS02655	COG3781	membrane
M1S43_RS02665	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M1S43_RS02670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1S43_RS02680	COG1862	Preprotein translocase
M1S43_RS02730	COG2205	protein histidine kinase activity
M1S43_RS02735	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M1S43_RS02755	COG0726	polysaccharide deacetylase
M1S43_RS02760	COG0463	Glycosyl transferase, family 2
M1S43_RS02765	COG0438	transferase activity, transferring glycosyl groups
M1S43_RS02830	COG0625	glutathione transferase activity
M1S43_RS02835	COG0583	DNA-binding transcription factor activity
M1S43_RS02840	COG1960	acyl-CoA dehydrogenase activity
M1S43_RS02845	COG1960	acyl-CoA dehydrogenase activity
M1S43_RS02855	COG2205	protein histidine kinase activity
M1S43_RS02860	COG0745	RESPONSE REGULATOR receiver
M1S43_RS02865	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M1S43_RS02885	COG2096	Adenosyltransferase
M1S43_RS02935	COG0285	dihydrofolate synthase activity
M1S43_RS02955	COG0450	alkyl hydroperoxide reductase
M1S43_RS02970	COG0477	Major facilitator Superfamily
M1S43_RS02975	COG1272	protein, Hemolysin III
M1S43_RS03005	COG0183	Belongs to the thiolase family
M1S43_RS03010	COG2207	Transcriptional regulator
M1S43_RS03030	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S43_RS03050	COG0183	Belongs to the thiolase family
M1S43_RS03060	COG2885	chlorophyll binding
M1S43_RS03060	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M1S43_RS03070	COG1690	Belongs to the RtcB family
M1S43_RS03075	COG0833	amino acid
M1S43_RS03085	COG2233	PERMEase
M1S43_RS03090	COG1217	gtp-binding protein TYPA
M1S43_RS03115	COG2094	Belongs to the DNA glycosylase MPG family
M1S43_RS03135	COG1902	pentaerythritol trinitrate reductase activity
M1S43_RS03150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S43_RS03155	COG0354	folic acid binding
M1S43_RS03165	COG3189	MarR family transcriptional regulator
M1S43_RS03170	COG2824	Alkylphosphonate utilization operon protein PhnA
M1S43_RS03175	COG3422	double-strand break repair
M1S43_RS03215	COG0840	transmembrane signaling receptor activity
M1S43_RS03235	COG5510	response to toxic substance
M1S43_RS03245	COG2832	Protein of unknown function (DUF454)
M1S43_RS03250	COG1376	ErfK ybiS ycfS ynhG family protein
M1S43_RS03290	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M1S43_RS03300	COG1289	transmembrane transporter activity
M1S43_RS03305	COG2814	Major facilitator Superfamily
M1S43_RS03325	COG1115	amino acid carrier protein
M1S43_RS03330	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S43_RS03335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S43_RS03340	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
M1S43_RS03370	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S43_RS03380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S43_RS03385	COG1077	Cell shape determining protein MreB Mrl
M1S43_RS03390	COG1792	Involved in formation and maintenance of cell shape
M1S43_RS03395	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M1S43_RS03400	COG0424	maF-like protein
M1S43_RS03405	COG1530	ribonuclease E activity
M1S43_RS03415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S43_RS03425	COG0560	Phosphoserine phosphatase
M1S43_RS03435	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S43_RS03460	COG2207	Transcriptional regulator
M1S43_RS03480	COG1113	amino acid transport
M1S43_RS03485	COG2828	Protein conserved in bacteria
M1S43_RS03490	COG0142	geranyltranstransferase activity
M1S43_RS03495	COG2315	Protein conserved in bacteria
M1S43_RS03510	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S43_RS03840	COG2194	sulfuric ester hydrolase activity
M1S43_RS03845	COG0745	RESPONSE REGULATOR receiver
M1S43_RS03850	COG0642	Histidine kinase
M1S43_RS03860	COG0004	ammonium transporteR
M1S43_RS03865	COG0583	DNA-binding transcription factor activity
M1S43_RS03885	COG0525	valine-tRNA ligase activity
M1S43_RS03895	COG1028	Short-chain dehydrogenase reductase Sdr
M1S43_RS03905	COG0393	Putative heavy-metal-binding
M1S43_RS03910	COG0393	Putative heavy-metal-binding
M1S43_RS03915	COG1538	Outer membrane efflux protein
M1S43_RS03925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S43_RS03930	COG0671	phosphoesterase, PA-phosphatase related
M1S43_RS03960	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M1S43_RS03975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M1S43_RS03975	COG1648	precorrin-2 dehydrogenase activity
M1S43_RS03980	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M1S43_RS03985	COG1733	regulation of RNA biosynthetic process
M1S43_RS03995	COG0531	amino acid
M1S43_RS04010	COG0321	lipoyl(octanoyl) transferase activity
M1S43_RS04015	COG2921	Belongs to the UPF0250 family
M1S43_RS04055	COG2009	succinate dehydrogenase
M1S43_RS04060	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M1S43_RS04065	COG1053	succinate dehydrogenase
M1S43_RS04070	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M1S43_RS04095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S43_RS04115	COG2354	Protein conserved in bacteria
M1S43_RS04120	COG2321	neutral zinc metallopeptidase
M1S43_RS04165	COG0589	response to stress
M1S43_RS04185	COG0505	Belongs to the CarA family
M1S43_RS04210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S43_RS04215	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M1S43_RS04265	COG0477	Major facilitator Superfamily
M1S43_RS04270	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M1S43_RS04285	COG1597	lipid kinase activity
M1S43_RS04290	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S43_RS04315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S43_RS04320	COG0584	glycerophosphoryl diester phosphodiesterase
M1S43_RS04340	COG0741	lytic transglycosylase activity
M1S43_RS04360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M1S43_RS04375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S43_RS04405	COG0778	Nitroreductase
M1S43_RS04420	COG1929	Belongs to the glycerate kinase type-1 family
M1S43_RS04430	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M1S43_RS04435	COG3339	Conserved Protein
M1S43_RS04445	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M1S43_RS04460	COG1113	amino acid transport
M1S43_RS04470	COG0019	diaminopimelate decarboxylase activity
M1S43_RS04480	COG1280	lysine exporter protein (LysE YggA)
M1S43_RS04485	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S43_RS04515	COG0463	Glycosyl transferase, family 2
M1S43_RS04535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S43_RS04570	COG4591	ABC-type transport system involved in lipoprotein release permease component
M1S43_RS04575	COG1136	(ABC) transporter
M1S43_RS04580	COG0658	competence protein
M1S43_RS04580	COG2333	competence protein COMEC
M1S43_RS04590	COG0616	signal peptide processing
M1S43_RS04590	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M1S43_RS04595	COG0596	Alpha beta hydrolase
M1S43_RS04600	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M1S43_RS04610	COG0628	permease
M1S43_RS04645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S43_RS04665	COG0823	Involved in the tonB-independent uptake of proteins
M1S43_RS04685	COG0824	Thioesterase
M1S43_RS04690	COG1473	amidohydrolase
M1S43_RS04710	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M1S43_RS04710	COG0047	phosphoribosylformylglycinamidine synthase activity
M1S43_RS04715	COG2814	Major facilitator Superfamily
M1S43_RS04725	COG1024	Enoyl-CoA hydratase
M1S43_RS04730	COG1051	belongs to the nudix hydrolase family
M1S43_RS04730	COG1056	cytidyltransferase-related domain
M1S43_RS04740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1S43_RS04755	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M1S43_RS04770	COG4625	pathogenesis
M1S43_RS04775	COG0583	DNA-binding transcription factor activity
M1S43_RS04780	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M1S43_RS04785	COG4208	sulfate ABC transporter
M1S43_RS04790	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M1S43_RS04800	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M1S43_RS04805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1S43_RS04810	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M1S43_RS04830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S43_RS04845	COG0681	Belongs to the peptidase S26 family
M1S43_RS04860	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M1S43_RS04870	COG1381	Involved in DNA repair and RecF pathway recombination
M1S43_RS04875	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M1S43_RS04885	COG4221	oxidoreductase activity
M1S43_RS04915	COG0436	Aminotransferase
M1S43_RS04935	COG0556	nucleotide-excision repair
M1S43_RS04990	COG2070	2-Nitropropane dioxygenase
M1S43_RS05020	COG1215	transferase activity, transferring glycosyl groups
M1S43_RS05035	COG0415	Belongs to the DNA photolyase family
M1S43_RS05045	COG1252	NADH dehydrogenase
M1S43_RS05050	COG1686	Belongs to the peptidase S11 family
M1S43_RS05065	COG1187	pseudouridine synthase activity
M1S43_RS05090	COG0477	Major facilitator Superfamily
M1S43_RS05095	COG0583	DNA-binding transcription factor activity
M1S43_RS05100	COG1823	symporter activity
M1S43_RS05110	COG0612	Peptidase, M16
M1S43_RS05135	COG0352	thiamine-phosphate diphosphorylase activity
M1S43_RS05170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S43_RS05185	COG1309	transcriptional regulator
M1S43_RS05195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S43_RS05200	COG0076	glutamate decarboxylase activity
M1S43_RS05210	COG1522	sequence-specific DNA binding
M1S43_RS05215	COG3961	Belongs to the TPP enzyme family
M1S43_RS05220	COG1113	amino acid transport
M1S43_RS05225	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S43_RS05230	COG0573	inorganic phosphate transmembrane transporter activity
M1S43_RS05240	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M1S43_RS05245	COG0616	signal peptide processing
M1S43_RS05280	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M1S43_RS05285	COG1686	Belongs to the peptidase S11 family
M1S43_RS05310	COG0583	DNA-binding transcription factor activity
M1S43_RS05315	COG1067	ATP-dependent peptidase activity
M1S43_RS05365	COG1966	Carbon starvation protein
M1S43_RS05370	COG2879	small protein
M1S43_RS05405	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M1S43_RS05405	COG2508	Transcriptional regulator
M1S43_RS05425	COG1113	amino acid transport
M1S43_RS05430	COG0583	DNA-binding transcription factor activity
M1S43_RS05435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S43_RS05440	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S43_RS05450	COG1012	belongs to the aldehyde dehydrogenase family
M1S43_RS05460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S43_RS05465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S43_RS05465	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M1S43_RS05500	COG2814	Major facilitator Superfamily
M1S43_RS05505	COG4948	Mandelate Racemase Muconate Lactonizing
M1S43_RS05515	COG1309	transcriptional regulator
M1S43_RS05535	COG1741	Belongs to the pirin family
M1S43_RS05545	COG2964	Protein conserved in bacteria
M1S43_RS05560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S43_RS05565	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S43_RS05570	COG4605	iron ion homeostasis
M1S43_RS05575	COG4604	ABC transporter, ATP-binding protein
M1S43_RS05580	COG4607	ABC-type enterochelin transport system periplasmic component
M1S43_RS05585	COG4774	siderophore transport
M1S43_RS05600	COG1021	2,3-dihydroxybenzoate-AMP ligase
M1S43_RS05605	COG3433	isochorismatase activity
M1S43_RS05605	COG1535	isochorismatase
M1S43_RS05620	COG1132	(ABC) transporter
M1S43_RS05625	COG1132	(ABC) transporter
M1S43_RS05630	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M1S43_RS05640	COG1169	isochorismate synthase
M1S43_RS05655	COG3739	integral membrane protein
M1S43_RS05680	COG0302	gtp cyclohydrolase
M1S43_RS05690	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M1S43_RS05720	COG0308	aminopeptidase N
M1S43_RS05725	COG0512	Glutamine amidotransferase of anthranilate synthase
M1S43_RS05740	COG0174	glutamine synthetase
M1S43_RS05750	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M1S43_RS05785	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1S43_RS05795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S43_RS05815	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S43_RS05820	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M1S43_RS05825	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M1S43_RS05840	COG1960	acyl-CoA dehydrogenase activity
M1S43_RS05845	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S43_RS05850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S43_RS05860	COG2223	nitrite transmembrane transporter activity
M1S43_RS05870	COG0024	Methionine aminopeptidase
M1S43_RS05875	COG0052	Belongs to the universal ribosomal protein uS2 family
M1S43_RS05890	COG2207	Transcriptional regulator
M1S43_RS05915	COG2951	lytic endotransglycosylase activity
M1S43_RS05920	COG0772	Belongs to the SEDS family
M1S43_RS05935	COG0842	Transport permease protein
M1S43_RS05940	COG1131	(ABC) transporter
M1S43_RS05985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S43_RS06000	COG4215	(ABC) transporter
M1S43_RS06005	COG4160	amino acid transport
M1S43_RS06010	COG4598	ABC transporter
M1S43_RS06020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S43_RS06025	COG0826	peptidase U32
M1S43_RS06030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S43_RS06045	COG1720	tRNA m6t6A37 methyltransferase activity
M1S43_RS06055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M1S43_RS06070	COG0642	Histidine kinase
M1S43_RS06080	COG0494	nUDIX hydrolase
M1S43_RS06090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1S43_RS06095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M1S43_RS06100	COG3139	Protein of unknown function (DUF1315)
M1S43_RS06105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M1S43_RS06110	COG1301	dicarboxylic acid transport
M1S43_RS06115	COG1960	acyl-CoA dehydrogenase activity
M1S43_RS06120	COG2819	hydrolase of the alpha beta superfamily
M1S43_RS06130	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M1S43_RS06140	COG2195	Cleaves the N-terminal amino acid of tripeptides
M1S43_RS06145	COG1234	tRNA 3'-trailer cleavage
M1S43_RS06175	COG2363	Small membrane protein
M1S43_RS06200	COG0513	Belongs to the DEAD box helicase family
M1S43_RS06210	COG0778	Nitroreductase
M1S43_RS06240	COG1286	toxin biosynthetic process
M1S43_RS06265	COG4783	chaperone-mediated protein folding
M1S43_RS06270	COG1610	YqeY-like protein
M1S43_RS06380	COG3111	PFAM Bacterial OB fold (BOF) protein
M1S43_RS06405	COG3243	poly(R)-hydroxyalkanoic acid synthase
M1S43_RS06410	COG0786	glutamate:sodium symporter activity
M1S43_RS06420	COG2186	Transcriptional regulator
M1S43_RS06470	COG0477	Major facilitator Superfamily
M1S43_RS06500	COG2985	domain, Protein
M1S43_RS06510	COG2995	paraquat-inducible protein a
M1S43_RS06515	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M1S43_RS06515	COG3008	intermembrane lipid transfer
M1S43_RS06525	COG1794	racemase activity, acting on amino acids and derivatives
M1S43_RS06620	COG0488	(ABC) transporter
M1S43_RS06625	COG3173	Aminoglycoside phosphotransferase
M1S43_RS06635	COG2433	Pfam Transposase IS66
M1S43_RS06675	COG1301	dicarboxylic acid transport
M1S43_RS06685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S43_RS06690	COG2011	ABC-type metal ion transport system permease component
M1S43_RS06695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S43_RS06700	COG1464	Belongs to the NlpA lipoprotein family
M1S43_RS06705	COG0151	Belongs to the GarS family
M1S43_RS06710	COG0138	bifunctional purine biosynthesis protein purh
M1S43_RS06715	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M1S43_RS06745	COG2308	Evidence 4 Homologs of previously reported genes of
M1S43_RS06755	COG1305	Transglutaminase-like
M1S43_RS06765	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M1S43_RS06770	COG0305	Participates in initiation and elongation during chromosome replication
M1S43_RS06795	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M1S43_RS06805	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M1S43_RS06810	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M1S43_RS06835	COG0726	polysaccharide deacetylase
M1S43_RS06835	COG1649	PFAM Uncharacterised BCR, COG1649
M1S43_RS06840	COG1215	transferase activity, transferring glycosyl groups
M1S43_RS06845	COG3658	cytochrome
M1S43_RS06855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S43_RS06870	COG0583	DNA-binding transcription factor activity
M1S43_RS06890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S43_RS06895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S43_RS06910	COG1960	acyl-CoA dehydrogenase activity
M1S43_RS06915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S43_RS06920	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S43_RS06945	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M1S43_RS06950	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M1S43_RS06960	COG2205	protein histidine kinase activity
M1S43_RS06965	COG0745	RESPONSE REGULATOR receiver
M1S43_RS06970	COG0174	glutamine synthetase
M1S43_RS06990	COG0729	surface antigen
M1S43_RS07015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S43_RS07020	COG2814	Major facilitator Superfamily
M1S43_RS07035	COG0583	DNA-binding transcription factor activity
M1S43_RS07050	COG1187	pseudouridine synthase activity
M1S43_RS07070	COG0802	atpase or kinase
M1S43_RS07075	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M1S43_RS07085	COG1923	regulation of RNA biosynthetic process
M1S43_RS07090	COG0697	spore germination
M1S43_RS07105	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S43_RS07115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S43_RS07120	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S43_RS07120	COG0519	Catalyzes the synthesis of GMP from XMP
M1S43_RS07125	COG4302	ethanolamine ammonia-lyase activity
M1S43_RS07130	COG4303	Ethanolamine ammonia lyase large subunit
M1S43_RS07135	COG0531	amino acid
M1S43_RS07155	COG1454	alcohol dehydrogenase
M1S43_RS07160	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S43_RS07170	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M1S43_RS07190	COG0308	aminopeptidase N
M1S43_RS07200	COG4221	oxidoreductase activity
M1S43_RS07210	COG1605	Chorismate mutase
M1S43_RS07230	COG1309	transcriptional regulator
M1S43_RS07240	COG0668	transmembrane transport
M1S43_RS07285	COG4773	Receptor
M1S43_RS07305	COG0488	(ABC) transporter
M1S43_RS07310	COG0589	response to stress
M1S43_RS07335	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M1S43_RS07345	COG3135	benzoate transporter
M1S43_RS07350	COG1522	sequence-specific DNA binding
M1S43_RS07360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M1S43_RS07365	COG0583	DNA-binding transcription factor activity
M1S43_RS07375	COG0183	Belongs to the thiolase family
M1S43_RS07385	COG2030	dehydratase
M1S43_RS07390	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S43_RS07405	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M1S43_RS07415	COG0824	Thioesterase
M1S43_RS07420	COG1454	alcohol dehydrogenase
M1S43_RS07450	COG0069	glutamate synthase activity
M1S43_RS07635	COG5410	chromosome segregation
M1S43_RS07745	COG1598	PFAM Uncharacterised protein family UPF0150
M1S43_RS07850	COG2814	Major facilitator Superfamily
M1S43_RS07865	COG0511	ligase activity, forming carbon-carbon bonds
M1S43_RS07885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S43_RS07885	COG1116	anion transmembrane transporter activity
M1S43_RS07890	COG0745	RESPONSE REGULATOR receiver
M1S43_RS07900	COG2146	nitrite reductase [NAD(P)H] activity
M1S43_RS07900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S43_RS07905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S43_RS07910	COG0243	molybdopterin cofactor binding
M1S43_RS07920	COG0243	molybdopterin cofactor binding
M1S43_RS07925	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1S43_RS07940	COG0521	Mo-molybdopterin cofactor biosynthetic process
M1S43_RS07940	COG0315	cyclic pyranopterin monophosphate synthase activity
M1S43_RS07945	COG0303	'Molybdopterin
M1S43_RS07955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S43_RS07960	COG0697	spore germination
M1S43_RS07980	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M1S43_RS07985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S43_RS08040	COG2204	response regulator
M1S43_RS08045	COG3852	Histidine kinase
M1S43_RS08065	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1S43_RS08070	COG0575	Belongs to the CDS family
M1S43_RS08105	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S43_RS08120	COG2137	regulation of response to DNA damage stimulus
M1S43_RS08130	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M1S43_RS08135	COG1011	Hydrolase
M1S43_RS08160	COG1522	sequence-specific DNA binding
M1S43_RS08170	COG1113	amino acid transport
M1S43_RS08190	COG0659	secondary active sulfate transmembrane transporter activity
M1S43_RS08195	COG2135	peptidase activity
M1S43_RS08210	COG5001	Diguanylate cyclase
M1S43_RS08210	COG3300	MHYT domain
M1S43_RS08230	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M1S43_RS08230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S43_RS08230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S43_RS08235	COG1105	Belongs to the carbohydrate kinase PfkB family
M1S43_RS08240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1S43_RS08240	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S43_RS08270	COG0024	Methionine aminopeptidase
M1S43_RS08275	COG0583	DNA-binding transcription factor activity
M1S43_RS08285	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M1S43_RS08290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S43_RS08295	COG0516	GMP reductase activity
M1S43_RS08295	COG0517	IMP dehydrogenase activity
M1S43_RS08320	COG0552	protein localization to endoplasmic reticulum
M1S43_RS08330	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M1S43_RS08345	COG4890	Cyd operon protein YbgT
M1S43_RS08350	COG1294	oxidase, subunit
M1S43_RS08365	COG1585	Membrane protein implicated in regulation of membrane protease activity
M1S43_RS08375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1S43_RS08380	COG4774	siderophore transport
M1S43_RS08395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1S43_RS08400	COG0569	domain protein
M1S43_RS08405	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S43_RS08435	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M1S43_RS08440	COG0542	response to heat
M1S43_RS08465	COG1902	pentaerythritol trinitrate reductase activity
M1S43_RS08465	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S43_RS08510	COG2323	membrane
M1S43_RS08515	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M1S43_RS08525	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S43_RS08530	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S43_RS08535	COG0183	Belongs to the thiolase family
M1S43_RS08540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M1S43_RS08545	COG0596	Alpha beta hydrolase
M1S43_RS08550	COG2271	Major facilitator Superfamily
M1S43_RS08555	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S43_RS08560	COG3485	protocatechuate 3,4-dioxygenase
M1S43_RS08565	COG3485	protocatechuate 3,4-dioxygenase
M1S43_RS08570	COG0710	3-dehydroquinate dehydratase activity
M1S43_RS08575	COG3420	alginic acid biosynthetic process
M1S43_RS08580	COG3659	wide pore channel activity
M1S43_RS08585	COG4993	Dehydrogenase
M1S43_RS08600	COG2391	methyltransferase activity
M1S43_RS08615	COG1414	Transcriptional regulator
M1S43_RS08620	COG0583	DNA-binding transcription factor activity
M1S43_RS08625	COG1960	acyl-CoA dehydrogenase activity
M1S43_RS08650	COG2814	Major facilitator Superfamily
M1S43_RS08660	COG0154	amidase activity
M1S43_RS08680	COG4638	Rieske (2fe-2S)
M1S43_RS08690	COG1028	Short-chain dehydrogenase reductase Sdr
M1S43_RS08700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S43_RS08710	COG3733	amine oxidase
M1S43_RS08720	COG1012	belongs to the aldehyde dehydrogenase family
M1S43_RS08730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S43_RS08735	COG0183	Belongs to the thiolase family
M1S43_RS08740	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S43_RS08745	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S43_RS08755	COG4829	muconolactone delta-isomerase
M1S43_RS08760	COG4948	Mandelate Racemase Muconate Lactonizing
M1S43_RS08765	COG0583	DNA-binding transcription factor activity
M1S43_RS08775	COG2186	Transcriptional regulator
M1S43_RS08795	COG1012	belongs to the aldehyde dehydrogenase family
M1S43_RS08815	COG1960	acyl-CoA dehydrogenase activity
M1S43_RS08820	COG1028	Short-chain dehydrogenase reductase Sdr
M1S43_RS08825	COG3829	transcription factor binding
M1S43_RS08835	COG3162	membrane
M1S43_RS08850	COG1012	belongs to the aldehyde dehydrogenase family
M1S43_RS08865	COG0753	catalase activity
M1S43_RS08885	COG1846	Transcriptional regulator
M1S43_RS08890	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S43_RS08890	COG1902	pentaerythritol trinitrate reductase activity
M1S43_RS08900	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M1S43_RS08930	COG1309	transcriptional regulator
M1S43_RS08940	COG1335	isochorismatase
M1S43_RS08945	COG0583	DNA-binding transcription factor activity
M1S43_RS08955	COG0475	glutathione-regulated potassium exporter activity
M1S43_RS08955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S43_RS08965	COG1473	amidohydrolase
M1S43_RS08975	COG2831	hemolysin activation secretion protein
M1S43_RS08980	COG3210	domain, Protein
M1S43_RS09010	COG2188	Transcriptional regulator
M1S43_RS09025	COG0583	DNA-binding transcription factor activity
M1S43_RS09055	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S43_RS09085	COG1566	PFAM secretion protein HlyD family protein
M1S43_RS09100	COG1012	belongs to the aldehyde dehydrogenase family
M1S43_RS09105	COG0129	dihydroxy-acid dehydratase activity
M1S43_RS09115	COG0583	DNA-binding transcription factor activity
M1S43_RS09120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1S43_RS09130	COG2084	Dehydrogenase
M1S43_RS09135	COG2207	Transcriptional regulator
M1S43_RS09150	COG1064	alcohol dehydrogenase
M1S43_RS09160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S43_RS09165	COG1120	ATPase activity
M1S43_RS09185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S43_RS09305	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M1S43_RS09355	COG1028	Short-chain dehydrogenase reductase Sdr
M1S43_RS09370	COG2207	Transcriptional regulator
M1S43_RS09380	COG2205	protein histidine kinase activity
M1S43_RS09385	COG0745	RESPONSE REGULATOR receiver
M1S43_RS09390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S43_RS09395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S43_RS09400	COG1538	Outer membrane efflux protein
M1S43_RS09410	COG2072	flavoprotein involved in K transport
M1S43_RS09430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S43_RS09450	COG3539	Fimbrial protein
M1S43_RS09480	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M1S43_RS09490	COG0753	catalase activity
M1S43_RS09505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S43_RS09565	COG1535	isochorismatase
M1S43_RS09565	COG3433	isochorismatase activity
M1S43_RS09570	COG1028	Short-chain dehydrogenase reductase Sdr
M1S43_RS09575	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M1S43_RS09580	COG4149	molybdate abc transporter
M1S43_RS09585	COG0725	ABC transporter, periplasmic molybdate-binding protein
M1S43_RS09595	COG4638	Rieske (2fe-2S)
M1S43_RS09600	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S43_RS09605	COG0543	2 iron, 2 sulfur cluster binding
M1S43_RS09605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S43_RS09630	COG1028	Short-chain dehydrogenase reductase Sdr
M1S43_RS09645	COG2207	Transcriptional regulator
M1S43_RS09655	COG1028	Short-chain dehydrogenase reductase Sdr
M1S43_RS09660	COG2610	gluconate transmembrane transporter activity
M1S43_RS09670	COG0583	DNA-binding transcription factor activity
M1S43_RS09680	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S43_RS09685	COG2031	fatty acid transporter
M1S43_RS09690	COG0183	Belongs to the thiolase family
M1S43_RS09695	COG0583	DNA-binding transcription factor activity
M1S43_RS09700	COG0583	DNA-binding transcription factor activity
M1S43_RS09715	COG1027	Aspartate ammonia-lyase
M1S43_RS09725	COG0477	Major facilitator Superfamily
M1S43_RS09745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S43_RS09750	COG4521	taurine ABC transporter
M1S43_RS09765	COG2188	Transcriptional regulator
M1S43_RS09775	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M1S43_RS09780	COG1733	regulation of RNA biosynthetic process
M1S43_RS09785	COG3708	Transcriptional regulator
M1S43_RS09785	COG2207	Transcriptional regulator
M1S43_RS09800	COG0730	response to heat
M1S43_RS09815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S43_RS09815	COG3453	Protein conserved in bacteria
M1S43_RS09825	COG3781	membrane
M1S43_RS09830	COG1063	alcohol dehydrogenase
M1S43_RS09840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S43_RS09845	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S43_RS09850	COG0022	dehydrogenase e1 component
M1S43_RS09855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1S43_RS09860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S43_RS09875	COG3706	GGDEF domain
M1S43_RS09890	COG0133	tryptophan synthase activity
M1S43_RS09900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S43_RS09935	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M1S43_RS09960	COG2226	methyltransferase
M1S43_RS10015	COG0842	Transport permease protein
M1S43_RS10020	COG0842	Transport permease protein
M1S43_RS10025	COG1131	(ABC) transporter
M1S43_RS10040	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S43_RS10045	COG4773	Receptor
M1S43_RS10065	COG0730	response to heat
M1S43_RS10070	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M1S43_RS10090	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M1S43_RS10105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S43_RS10145	COG4264	IucA IucC family
M1S43_RS10150	COG4264	IucA IucC family
M1S43_RS10170	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M1S43_RS10185	COG1960	acyl-CoA dehydrogenase activity
M1S43_RS10190	COG1960	acyl-CoA dehydrogenase activity
M1S43_RS10195	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S43_RS10200	COG2207	Transcriptional regulator
M1S43_RS10205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S43_RS10210	COG0776	regulation of translation
M1S43_RS10235	COG0822	iron-sulfur transferase activity
M1S43_RS10240	COG0316	Belongs to the HesB IscA family
M1S43_RS10270	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S43_RS10290	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S43_RS10295	COG0702	epimerase
M1S43_RS10330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1S43_RS10340	COG0339	signal peptide processing
M1S43_RS10390	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M1S43_RS10395	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M1S43_RS10425	COG0776	regulation of translation
M1S43_RS10490	COG0084	hydrolase, TatD family'
M1S43_RS10510	COG1663	tetraacyldisaccharide 4'-kinase activity
M1S43_RS10515	COG1132	(ABC) transporter
M1S43_RS10525	COG0811	peptide transport
M1S43_RS10530	COG1475	DNA binding
M1S43_RS10535	COG1192	Involved in chromosome partitioning
M1S43_RS10545	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M1S43_RS10560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S43_RS10565	COG0191	fructose-bisphosphate aldolase activity
M1S43_RS10585	COG0424	maF-like protein
M1S43_RS10590	COG2850	peptidyl-arginine hydroxylation
M1S43_RS10600	COG0640	Transcriptional regulator
M1S43_RS10610	COG3619	membrane
M1S43_RS10615	COG3122	Protein conserved in bacteria
M1S43_RS10620	COG1132	(ABC) transporter
M1S43_RS10640	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M1S43_RS10645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S43_RS10655	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S43_RS10655	COG0506	proline dehydrogenase activity
M1S43_RS10655	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S43_RS10660	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M1S43_RS10675	COG3698	Phosphodiester glycosidase
M1S43_RS10685	COG2353	YceI-like domain
M1S43_RS10695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M1S43_RS10740	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M1S43_RS10740	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M1S43_RS10765	COG3539	Fimbrial protein
M1S43_RS10770	COG3121	Chaperone
M1S43_RS10795	COG0697	spore germination
M1S43_RS10805	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S43_RS10815	COG0583	DNA-binding transcription factor activity
M1S43_RS10835	COG1309	transcriptional regulator
M1S43_RS10850	COG1522	sequence-specific DNA binding
M1S43_RS10860	COG1126	abc transporter atp-binding protein
M1S43_RS10865	COG0765	amino acid transport
M1S43_RS10870	COG0765	amino acid transport
M1S43_RS10900	COG1464	Belongs to the NlpA lipoprotein family
M1S43_RS10910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S43_RS10915	COG2011	ABC-type metal ion transport system permease component
M1S43_RS10920	COG0012	GTP binding
M1S43_RS10945	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S43_RS10985	COG0386	Belongs to the glutathione peroxidase family
M1S43_RS10995	COG0436	Aminotransferase
M1S43_RS11050	COG0583	DNA-binding transcription factor activity
M1S43_RS11055	COG0798	PFAM Bile acid sodium symporter
M1S43_RS11060	COG0640	Transcriptional regulator
M1S43_RS11075	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M1S43_RS11085	COG0583	DNA-binding transcription factor activity
M1S43_RS11095	COG1953	Uracil, thiamine, allantoin
M1S43_RS11105	COG2175	clavaminate synthase activity
M1S43_RS11110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S43_RS11115	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M1S43_RS11120	COG4521	taurine ABC transporter
M1S43_RS11130	COG0477	Major facilitator Superfamily
M1S43_RS11150	COG1271	oxidase subunit
M1S43_RS11155	COG1294	oxidase, subunit
M1S43_RS11165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S43_RS11185	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M1S43_RS11205	COG3052	prosthetic group binding
M1S43_RS11210	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
M1S43_RS11220	COG2814	Major facilitator Superfamily
M1S43_RS11240	COG1346	cytolysis
M1S43_RS11250	COG0583	DNA-binding transcription factor activity
M1S43_RS11255	COG0625	glutathione transferase activity
M1S43_RS11260	COG0625	glutathione transferase activity
M1S43_RS11265	COG0583	DNA-binding transcription factor activity
M1S43_RS11280	COG1045	serine acetyltransferase
M1S43_RS11285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S43_RS11290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M1S43_RS11300	COG1280	lysine exporter protein (LysE YggA)
M1S43_RS11315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S43_RS11320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S43_RS11325	COG1126	abc transporter atp-binding protein
M1S43_RS11330	COG0765	amino acid transport
M1S43_RS11335	COG0765	amino acid transport
M1S43_RS11355	COG0784	Response regulator, receiver
M1S43_RS11355	COG2205	protein histidine kinase activity
M1S43_RS11375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S43_RS11395	COG1028	Short-chain dehydrogenase reductase Sdr
M1S43_RS11445	COG0583	DNA-binding transcription factor activity
M1S43_RS11465	COG0318	PFAM AMP-dependent synthetase and ligase
M1S43_RS11470	COG1309	transcriptional regulator
M1S43_RS11475	COG1960	acyl-CoA dehydrogenase activity
M1S43_RS11480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S43_RS11485	COG1024	Enoyl-CoA hydratase
M1S43_RS11490	COG4770	biotin carboxylase activity
M1S43_RS11500	COG0583	DNA-binding transcription factor activity
M1S43_RS11515	COG1960	acyl-CoA dehydrogenase activity
M1S43_RS11525	COG2814	Major facilitator Superfamily
M1S43_RS11535	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S43_RS11540	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S43_RS11545	COG2814	Major facilitator Superfamily
M1S43_RS11550	COG1960	acyl-CoA dehydrogenase activity
M1S43_RS11555	COG1024	Enoyl-CoA hydratase
M1S43_RS11560	COG1028	Short-chain dehydrogenase reductase Sdr
M1S43_RS11565	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S43_RS11570	COG0183	Belongs to the thiolase family
M1S43_RS11580	COG2814	Major facilitator Superfamily
M1S43_RS11590	COG1024	Enoyl-CoA hydratase
M1S43_RS11605	COG1960	acyl-CoA dehydrogenase activity
M1S43_RS11610	COG2814	Major facilitator Superfamily
M1S43_RS11615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S43_RS11620	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M1S43_RS11635	COG3842	ATPase activity
M1S43_RS11640	COG1840	ABC-type Fe3 transport system, periplasmic component
M1S43_RS11650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S43_RS11655	COG1414	Transcriptional regulator
M1S43_RS11665	COG0583	DNA-binding transcription factor activity
M1S43_RS11670	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S43_RS11675	COG1012	belongs to the aldehyde dehydrogenase family
M1S43_RS11685	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S43_RS11695	COG1012	belongs to the aldehyde dehydrogenase family
M1S43_RS11700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S43_RS11705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S43_RS11710	COG2267	carboxylic ester hydrolase activity
M1S43_RS11730	COG3038	cytochrome b561
M1S43_RS11735	COG0753	catalase activity
M1S43_RS11770	COG2050	protein possibly involved in aromatic compounds catabolism
M1S43_RS11780	COG3327	negative regulation of DNA-templated transcription, initiation
M1S43_RS11785	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
M1S43_RS11790	COG0183	Belongs to the thiolase family
M1S43_RS11795	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S43_RS11800	COG1024	Enoyl-CoA hydratase
M1S43_RS11805	COG1024	Enoyl-CoA hydratase
M1S43_RS11810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S43_RS11815	COG2151	metal-sulfur cluster biosynthetic enzyme
M1S43_RS11820	COG3396	Phenylacetate-CoA oxygenase
M1S43_RS11825	COG3460	Phenylacetate-CoA oxygenase
M1S43_RS11830	COG3396	Phenylacetate-CoA oxygenase
M1S43_RS11835	COG2030	dehydratase
M1S43_RS11835	COG1012	belongs to the aldehyde dehydrogenase family
M1S43_RS11840	COG1760	l-serine dehydratase
M1S43_RS11845	COG0531	amino acid
M1S43_RS11850	COG1012	belongs to the aldehyde dehydrogenase family
M1S43_RS11865	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S43_RS11875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S43_RS11895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S43_RS11905	COG0789	Transcriptional regulator
M1S43_RS11920	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M1S43_RS11935	COG2807	transmembrane transport
M1S43_RS11940	COG0590	tRNA wobble adenosine to inosine editing
M1S43_RS12060	COG1116	anion transmembrane transporter activity
M1S43_RS12065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S43_RS12075	COG0864	Transcriptional regulator
M1S43_RS12095	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S43_RS12100	COG0439	Biotin carboxylase
M1S43_RS12115	COG1063	alcohol dehydrogenase
M1S43_RS12125	COG1309	transcriptional regulator
M1S43_RS12145	COG0038	chloride channel
M1S43_RS12150	COG4770	biotin carboxylase activity
M1S43_RS12170	COG1914	H( )-stimulated, divalent metal cation uptake system
M1S43_RS12175	COG0583	DNA-binding transcription factor activity
M1S43_RS12225	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S43_RS12245	COG2814	Major facilitator Superfamily
M1S43_RS12260	COG1560	Kdo2-lipid A biosynthetic process
M1S43_RS12270	COG5006	permease, DMT superfamily
M1S43_RS12275	COG1522	sequence-specific DNA binding
M1S43_RS12290	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M1S43_RS12300	COG4122	O-methyltransferase activity
M1S43_RS12330	COG1538	Outer membrane efflux protein
M1S43_RS12335	COG1137	ATPase activity
M1S43_RS12340	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M1S43_RS12350	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M1S43_RS12355	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M1S43_RS12355	COG0517	IMP dehydrogenase activity
M1S43_RS12390	COG2814	Major facilitator Superfamily
M1S43_RS12425	COG1278	Cold shock
M1S43_RS12430	COG1280	lysine exporter protein (LysE YggA)
M1S43_RS12460	COG1570	exodeoxyribonuclease VII activity
M1S43_RS12510	COG0583	DNA-binding transcription factor activity
M1S43_RS12520	COG4638	Rieske (2fe-2S)
M1S43_RS12525	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S43_RS12530	COG0633	Ferredoxin
M1S43_RS12530	COG0543	2 iron, 2 sulfur cluster binding
M1S43_RS12535	COG1028	Short-chain dehydrogenase reductase Sdr
M1S43_RS12540	COG3135	benzoate transporter
M1S43_RS12545	COG2814	Major facilitator Superfamily
M1S43_RS12560	COG1643	Atp-dependent helicase
M1S43_RS12565	COG0450	alkyl hydroperoxide reductase
M1S43_RS12575	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M1S43_RS12605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M1S43_RS12610	COG0625	glutathione transferase activity
M1S43_RS12620	COG2885	chlorophyll binding
M1S43_RS12655	COG0542	response to heat
M1S43_RS12670	COG1765	OsmC-like protein
M1S43_RS12690	COG0667	Aldo Keto reductase
M1S43_RS12705	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M1S43_RS12715	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M1S43_RS12725	COG0527	aspartate kinase activity
M1S43_RS12735	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M1S43_RS12745	COG3038	cytochrome b561
M1S43_RS12750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M1S43_RS12755	COG2252	PERMEase
M1S43_RS12765	COG2072	flavoprotein involved in K transport
M1S43_RS12780	COG1741	Belongs to the pirin family
M1S43_RS12785	COG1309	transcriptional regulator
M1S43_RS12795	COG0300	oxidoreductase activity
M1S43_RS12905	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M1S43_RS12955	COG1012	belongs to the aldehyde dehydrogenase family
M1S43_RS12975	COG0531	amino acid
M1S43_RS12985	COG1113	amino acid transport
M1S43_RS13065	COG4269	membrane
M1S43_RS13080	COG1902	pentaerythritol trinitrate reductase activity
M1S43_RS13080	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S43_RS13090	COG3706	GGDEF domain
M1S43_RS13090	COG2203	Gaf domain
M1S43_RS13090	COG5001	Diguanylate cyclase
M1S43_RS13090	COG4251	negative regulation of phosphorylation
M1S43_RS13100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S43_RS13120	COG4172	Belongs to the ABC transporter superfamily
M1S43_RS13125	COG4239	(ABC) transporter, permease
M1S43_RS13130	COG4174	ABC transporter (Permease)
M1S43_RS13140	COG0741	lytic transglycosylase activity
M1S43_RS13140	COG1388	LysM domain
M1S43_RS13140	COG1388	LysM domain
M1S43_RS13140	COG0741	lytic transglycosylase activity
M1S43_RS13145	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S43_RS13185	COG0583	DNA-binding transcription factor activity
M1S43_RS13190	COG1279	arginine transmembrane transporter activity
M1S43_RS13210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S43_RS13215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S43_RS13220	COG0006	proline dipeptidase activity
M1S43_RS13305	COG1196	nuclear chromosome segregation
M1S43_RS13305	COG0739	heme binding
M1S43_RS13305	COG0741	lytic transglycosylase activity
M1S43_RS13365	COG4695	Portal protein
M1S43_RS13465	COG0305	Participates in initiation and elongation during chromosome replication
M1S43_RS13480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S43_RS13535	COG2194	sulfuric ester hydrolase activity
M1S43_RS13905	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M1S43_RS13930	COG3384	dioxygenase
M1S43_RS13940	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S43_RS13945	COG2878	Part of a membrane complex involved in electron transport
M1S43_RS13950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M1S43_RS13975	COG0768	penicillin binding
M1S43_RS13980	COG0742	ribosomal rna small subunit methyltransferase
M1S43_RS13995	COG0830	nickel cation binding
M1S43_RS14005	COG0804	urea catabolic process
M1S43_RS14045	COG1253	flavin adenine dinucleotide binding
M1S43_RS14050	COG2851	Citrate transporter
M1S43_RS14100	COG1773	rubredoxin
M1S43_RS14105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S43_RS14115	COG0583	DNA-binding transcription factor activity
M1S43_RS14140	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M1S43_RS14145	COG4181	ATPase activity
M1S43_RS14190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M1S43_RS14210	COG0306	phosphate transporter
M1S43_RS14220	COG3958	Transketolase
M1S43_RS14225	COG3959	Transketolase, thiamine diphosphate binding domain
M1S43_RS14230	COG2271	Major facilitator Superfamily
M1S43_RS14235	COG1028	Short-chain dehydrogenase reductase Sdr
M1S43_RS14240	COG0583	DNA-binding transcription factor activity
M1S43_RS14255	COG2223	nitrite transmembrane transporter activity
M1S43_RS14260	COG2207	Transcriptional regulator
M1S43_RS14265	COG2066	Belongs to the glutaminase family
M1S43_RS14270	COG0242	peptide deformylase activity
M1S43_RS14275	COG0477	Major facilitator Superfamily
M1S43_RS14285	COG0028	Belongs to the TPP enzyme family
M1S43_RS14300	COG1028	Short-chain dehydrogenase reductase Sdr
M1S43_RS14305	COG2267	carboxylic ester hydrolase activity
M1S43_RS14315	COG2271	Major facilitator Superfamily
M1S43_RS14320	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S43_RS14330	COG1028	Short-chain dehydrogenase reductase Sdr
M1S43_RS14350	COG1414	Transcriptional regulator
M1S43_RS14365	COG1024	Enoyl-CoA hydratase
M1S43_RS14375	COG1215	transferase activity, transferring glycosyl groups
M1S43_RS14380	COG0726	polysaccharide deacetylase
M1S43_RS14380	COG1649	PFAM Uncharacterised BCR, COG1649
M1S43_RS14390	COG4681	YaeQ
M1S43_RS14400	COG0523	cobalamin synthesis protein
M1S43_RS14410	COG1607	acyl-coa hydrolase
M1S43_RS14420	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S43_RS14425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S43_RS14430	COG1309	transcriptional regulator
M1S43_RS14455	COG2040	homocysteine
M1S43_RS14460	COG0531	amino acid
M1S43_RS14485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S43_RS14490	COG0477	Major facilitator Superfamily
M1S43_RS14610	COG0592	DNA-directed DNA polymerase activity
M1S43_RS14650	COG2026	Addiction module toxin, RelE StbE family
M1S43_RS14805	COG3755	Protein conserved in bacteria
M1S43_RS14850	COG1484	DNA-dependent DNA replication
M1S43_RS14940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S43_RS15010	COG0405	Gamma-glutamyltransferase
M1S43_RS15015	COG2814	Major facilitator Superfamily
M1S43_RS15025	COG2050	protein possibly involved in aromatic compounds catabolism
M1S43_RS15040	COG1090	epimerase
M1S43_RS15060	COG0420	3'-5' exonuclease activity
M1S43_RS15085	COG0735	belongs to the Fur family
M1S43_RS15090	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M1S43_RS15110	COG0121	glutamine amidotransferase
M1S43_RS15125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S43_RS15135	COG0210	DNA helicase
M1S43_RS15140	COG2885	chlorophyll binding
M1S43_RS15160	COG2894	cell division
M1S43_RS15185	COG1280	lysine exporter protein (LysE YggA)
M1S43_RS15190	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M1S43_RS15190	COG1674	ftsk spoiiie
M1S43_RS15195	COG0492	ferredoxin-NADP+ reductase activity
M1S43_RS15200	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M1S43_RS15210	COG0456	acetyltransferase
M1S43_RS15255	COG1981	membrane
M1S43_RS15270	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M1S43_RS15270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S43_RS15290	COG1012	belongs to the aldehyde dehydrogenase family
M1S43_RS15300	COG0657	acetylesterase activity
M1S43_RS15310	COG0473	3-isopropylmalate dehydrogenase activity
M1S43_RS15315	COG0583	DNA-binding transcription factor activity
M1S43_RS15335	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S43_RS15360	COG0564	pseudouridine synthase activity
M1S43_RS15370	COG0358	DNA primase activity
M1S43_RS15385	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M1S43_RS15415	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S43_RS15445	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M1S43_RS15455	COG0352	thiamine-phosphate diphosphorylase activity
M1S43_RS15455	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S43_RS15455	COG0351	phosphomethylpyrimidine kinase
M1S43_RS15460	COG1652	LysM domain
M1S43_RS15485	COG1399	metal-binding, possibly nucleic acid-binding protein
M1S43_RS15490	COG3101	peptidyl-lysine hydroxylation
M1S43_RS15495	COG0009	L-threonylcarbamoyladenylate synthase
M1S43_RS15500	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M1S43_RS15505	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M1S43_RS15520	COG4106	trans-aconitate 2-methyltransferase activity
M1S43_RS15535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S43_RS15535	COG0596	Alpha beta hydrolase
M1S43_RS15535	COG2226	methyltransferase
M1S43_RS15540	COG1877	trehalose-phosphatase activity
M1S43_RS15545	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
M1S43_RS15550	COG2223	nitrite transmembrane transporter activity
M1S43_RS15570	COG1196	nuclear chromosome segregation
M1S43_RS15580	COG0730	response to heat
M1S43_RS15595	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M1S43_RS15605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S43_RS15655	COG0489	protein tyrosine kinase activity
M1S43_RS15665	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S43_RS15665	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S43_RS15695	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M1S43_RS15700	COG2081	HI0933 family
M1S43_RS15710	COG0668	transmembrane transport
M1S43_RS15730	COG0583	DNA-binding transcription factor activity
M1S43_RS15750	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1S43_RS15755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S43_RS15785	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M1S43_RS15825	COG0745	RESPONSE REGULATOR receiver
M1S43_RS15845	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S43_RS15855	COG2205	protein histidine kinase activity
M1S43_RS15925	COG4993	Dehydrogenase
M1S43_RS15950	COG0384	phenazine biosynthesis protein PhzF
M1S43_RS15975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S43_RS15990	COG0583	DNA-binding transcription factor activity
M1S43_RS16020	COG0583	DNA-binding transcription factor activity
M1S43_RS16035	COG0583	DNA-binding transcription factor activity
M1S43_RS16040	COG1053	succinate dehydrogenase
M1S43_RS16050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M1S43_RS16055	COG2814	Major facilitator Superfamily
M1S43_RS16060	COG1960	acyl-CoA dehydrogenase activity
M1S43_RS16065	COG0583	DNA-binding transcription factor activity
M1S43_RS16070	COG1063	alcohol dehydrogenase
M1S43_RS16100	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M1S43_RS16105	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M1S43_RS16110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S43_RS16130	COG2132	Multicopper oxidase
M1S43_RS16140	COG0561	phosphatase activity
M1S43_RS16145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M1S43_RS16170	COG1214	PFAM Peptidase M22, glycoprotease
M1S43_RS16220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M1S43_RS16230	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M1S43_RS16235	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M1S43_RS16240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M1S43_RS16300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S43_RS16310	COG1846	Transcriptional regulator
M1S43_RS16315	COG1764	response to oxidative stress
M1S43_RS16355	COG0037	tRNA processing
M1S43_RS16365	COG0248	Ppx GppA phosphatase
M1S43_RS16395	COG0072	phenylalanine-tRNA ligase activity
M1S43_RS16440	COG1238	metal cluster binding
M1S43_RS16445	COG0625	glutathione transferase activity
M1S43_RS16460	COG0318	PFAM AMP-dependent synthetase and ligase
M1S43_RS16465	COG3028	Belongs to the UPF0307 family
M1S43_RS16470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S43_RS16490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M1S43_RS16495	COG0617	tRNA 3'-terminal CCA addition
M1S43_RS16500	COG1555	photosystem II stabilization
M1S43_RS16505	COG3956	TIGRFAM MazG family protein
M1S43_RS16515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S43_RS16535	COG0784	Response regulator, receiver
M1S43_RS16535	COG5002	protein histidine kinase activity
M1S43_RS16535	COG2205	protein histidine kinase activity
M1S43_RS16540	COG1024	Enoyl-CoA hydratase
M1S43_RS16545	COG2084	Dehydrogenase
M1S43_RS16550	COG3622	Belongs to the hyi family
M1S43_RS16580	COG0697	spore germination
M1S43_RS16590	COG2814	Major facilitator Superfamily
M1S43_RS16595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S43_RS16605	COG0583	DNA-binding transcription factor activity
M1S43_RS16615	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M1S43_RS16630	COG0084	hydrolase, TatD family'
M1S43_RS16645	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M1S43_RS16675	COG0440	acetolactate synthase activity
M1S43_RS16680	COG0028	Belongs to the TPP enzyme family
M1S43_RS16705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S43_RS16710	COG0577	efflux transmembrane transporter activity
M1S43_RS16710	COG1136	(ABC) transporter
M1S43_RS16715	COG1538	Outer membrane efflux protein
M1S43_RS16730	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M1S43_RS16735	COG1162	GTPase activity
M1S43_RS16745	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M1S43_RS16765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M1S43_RS16770	COG1028	Short-chain dehydrogenase reductase Sdr
M1S43_RS16810	COG2986	histidine ammonia-lyase
M1S43_RS16825	COG0318	PFAM AMP-dependent synthetase and ligase
M1S43_RS16835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S43_RS16880	COG1426	Protein conserved in bacteria
M1S43_RS16915	COG0793	Belongs to the peptidase S41A family
M1S43_RS16930	COG2267	carboxylic ester hydrolase activity
M1S43_RS16940	COG1012	belongs to the aldehyde dehydrogenase family
M1S43_RS16945	COG3265	gluconokinase activity
M1S43_RS16955	COG0800	Aldolase
M1S43_RS16965	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M1S43_RS16970	COG0280	phosphate acetyltransferase
M1S43_RS16970	COG0857	belongs to the CobB CobQ family
M1S43_RS16975	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S43_RS16975	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S43_RS16995	COG0740	serine-type endopeptidase activity
M1S43_RS17005	COG4774	siderophore transport
M1S43_RS17015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1S43_RS17025	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S43_RS17025	COG2813	Specifically methylates the guanine in position
M1S43_RS17125	COG0788	formyltetrahydrofolate deformylase activity
M1S43_RS17150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S43_RS17150	COG4651	solute:proton antiporter activity
M1S43_RS17170	COG0724	RNA recognition motif
M1S43_RS17175	COG0210	DNA helicase
M1S43_RS17200	COG1733	regulation of RNA biosynthetic process
M1S43_RS17210	COG2900	Belongs to the SlyX family
M1S43_RS17215	COG0488	(ABC) transporter
M1S43_RS17220	COG1280	lysine exporter protein (LysE YggA)
M1S43_RS17225	COG1560	Kdo2-lipid A biosynthetic process
M1S43_RS17235	COG1301	dicarboxylic acid transport
M1S43_RS17290	COG0473	3-isopropylmalate dehydrogenase activity
M1S43_RS17355	COG0583	DNA-binding transcription factor activity
M1S43_RS17365	COG0625	glutathione transferase activity
M1S43_RS17370	COG2378	regulation of single-species biofilm formation
M1S43_RS17375	COG0546	phosphoglycolate phosphatase activity
M1S43_RS17385	COG1530	ribonuclease E activity
M1S43_RS17390	COG0318	PFAM AMP-dependent synthetase and ligase
M1S43_RS17405	COG0583	DNA-binding transcription factor activity
M1S43_RS17410	COG4221	oxidoreductase activity
M1S43_RS17415	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M1S43_RS17425	COG0534	Mate efflux family protein
M1S43_RS17440	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M1S43_RS17480	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M1S43_RS17485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S43_RS17500	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S43_RS17510	COG0644	oxidoreductase
M1S43_RS17510	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
M1S43_RS17515	COG0425	Belongs to the sulfur carrier protein TusA family
M1S43_RS17520	COG4535	Mg2 and Co2 transporter CorC
M1S43_RS17530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S43_RS17550	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M1S43_RS17555	COG0475	glutathione-regulated potassium exporter activity
M1S43_RS17555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S43_RS17560	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M1S43_RS17570	COG0484	heat shock protein binding
M1S43_RS17575	COG0789	Transcriptional regulator
M1S43_RS17580	COG0598	Magnesium transport protein CorA
M1S43_RS17595	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S43_RS17600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S43_RS17605	COG1074	ATP-dependent DNA helicase activity
M1S43_RS17610	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M1S43_RS17630	COG2226	methyltransferase
M1S43_RS17645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S43_RS17650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M1S43_RS17665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S43_RS17665	COG2111	Na H antiporter
M1S43_RS17670	COG1006	Multisubunit Na H antiporter MnhC subunit
M1S43_RS17675	COG0651	ATP synthesis coupled electron transport
M1S43_RS17680	COG1863	multisubunit Na H antiporter MnhE subunit
M1S43_RS17685	COG2212	antiporter activity
M1S43_RS17690	COG1320	monovalent cation:proton antiporter activity
M1S43_RS17705	COG0195	Participates in both transcription termination and antitermination
M1S43_RS17755	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M1S43_RS17760	COG0237	dephospho-CoA kinase activity
M1S43_RS17770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S43_RS17785	COG0497	DNA recombination
M1S43_RS17795	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M1S43_RS17825	COG2169	Transcriptional regulator
M1S43_RS17825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S43_RS17830	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M1S43_RS17895	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M1S43_RS17910	COG0326	Molecular chaperone. Has ATPase activity
M1S43_RS17925	COG2056	Na+-H+ antiporter family
M1S43_RS17930	COG0596	Alpha beta hydrolase
M1S43_RS18025	COG0546	phosphoglycolate phosphatase activity
M1S43_RS18030	COG1716	ATPase activity
M1S43_RS18075	COG0181	hydroxymethylbilane synthase activity
M1S43_RS18085	COG3275	phosphorelay sensor kinase activity
M1S43_RS18105	COG1538	Outer membrane efflux protein
M1S43_RS18110	COG0697	spore germination
M1S43_RS18135	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S43_RS18140	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M1S43_RS18145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S43_RS18150	COG0772	Belongs to the SEDS family
M1S43_RS18175	COG4974	Belongs to the 'phage' integrase family
M1S43_RS18180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S43_RS18190	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M1S43_RS18200	COG2197	response regulator
M1S43_RS18215	COG0793	Belongs to the peptidase S41A family
M1S43_RS18220	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M1S43_RS18225	COG0795	lipopolysaccharide-transporting ATPase activity
M1S43_RS18265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S43_RS18265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S43_RS18275	COG0004	ammonium transporteR
M1S43_RS18280	COG0347	Belongs to the P(II) protein family
M1S43_RS18340	COG0659	secondary active sulfate transmembrane transporter activity
M1S43_RS18345	COG0589	response to stress
M1S43_RS18385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S43_RS18430	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S43_RS18460	COG0659	secondary active sulfate transmembrane transporter activity
M1S43_RS18465	COG0589	response to stress
M1S43_RS18500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S43_RS18510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S43_RS18530	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M1S43_RS18545	COG0318	PFAM AMP-dependent synthetase and ligase
M1S43_RS18555	COG0477	Major facilitator Superfamily
M1S43_RS18560	COG2860	membrane
M1S43_RS18570	COG1253	flavin adenine dinucleotide binding
M1S43_RS18590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1S43_RS18630	COG0655	NAD(P)H dehydrogenase (quinone) activity
M1S43_RS18640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M1S43_RS18710	COG0758	DNA mediated transformation
M1S43_RS18720	COG0697	spore germination
M1S43_RS18725	COG1309	transcriptional regulator
M1S43_RS18740	COG0386	Belongs to the glutathione peroxidase family
M1S43_RS18805	COG1121	(ABC) transporter
M1S43_RS18810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1S43_RS18815	COG1280	lysine exporter protein (LysE YggA)
M1S43_RS18820	COG2837	iron assimilation
M1S43_RS18830	COG0281	malic enzyme
M1S43_RS18875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S43_RS18875	COG0519	Catalyzes the synthesis of GMP from XMP
M1S43_RS18880	COG4399	Belongs to the UPF0754 family
M1S43_RS18885	COG2259	Doxx family
M1S43_RS18890	COG0586	Pfam SNARE associated Golgi protein
M1S43_RS18905	COG1192	Involved in chromosome partitioning
M1S43_RS18915	COG0271	Belongs to the BolA IbaG family
M1S43_RS18935	COG2267	carboxylic ester hydrolase activity
M1S43_RS18955	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M1S43_RS18955	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M1S43_RS18955	COG3321	synthase
M1S43_RS18955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S43_RS18960	COG1960	acyl-CoA dehydrogenase activity
M1S43_RS18970	COG2197	response regulator
M1S43_RS18980	COG3916	Acyl-homoserine-lactone synthase
M1S43_RS18985	COG0477	Major facilitator Superfamily
M1S43_RS18990	COG1024	Enoyl-CoA hydratase
M1S43_RS18995	COG1024	Enoyl-CoA hydratase
M1S43_RS19000	COG1960	acyl-CoA dehydrogenase activity
M1S43_RS19005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S43_RS19025	COG1113	amino acid transport
M1S43_RS19030	COG1113	amino acid transport
M1S43_RS19035	COG0251	oxidation-reduction process
M1S43_RS19075	COG0564	pseudouridine synthase activity
M1S43_RS19135	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M1S43_RS19150	COG1802	Transcriptional regulator
M1S43_RS19160	COG1448	Aminotransferase
M1S43_RS19165	COG0277	FAD linked oxidase domain protein
M1S43_RS19175	COG2186	Transcriptional regulator
M1S43_RS19185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S43_RS19190	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S43_RS19205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M1S43_RS19210	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M1S43_RS19215	COG1216	Glycosyl transferase, family 2
M1S43_RS19245	COG2089	acid synthase
M1S43_RS19260	COG1083	cytidylyl-transferase
M1S43_RS19265	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M1S43_RS19270	COG1086	Polysaccharide biosynthesis protein
M1S43_RS19275	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M1S43_RS19280	COG1596	polysaccharide export
M1S43_RS19305	COG0728	peptidoglycan biosynthetic process
M1S43_RS19310	COG3023	N-Acetylmuramoyl-L-alanine amidase
M1S43_RS19370	COG0546	phosphoglycolate phosphatase activity
M1S43_RS19375	COG1028	Short-chain dehydrogenase reductase Sdr
M1S43_RS19395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S43_RS19400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S43_RS19405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S43_RS19410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S43_RS19415	COG1116	anion transmembrane transporter activity
M1S43_RS19420	COG1309	transcriptional regulator
M1S43_RS19425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M1S43_RS19435	COG0196	riboflavin kinase activity
M1S43_RS19440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M1S43_RS19450	COG1047	Peptidyl-prolyl cis-trans
M1S43_RS19490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M1S43_RS19495	COG0657	acetylesterase activity
M1S43_RS19515	COG0583	DNA-binding transcription factor activity
M1S43_RS19545	COG2951	lytic endotransglycosylase activity
M1S43_RS19550	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M1S43_RS19565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M1S43_RS19575	COG0671	phosphoesterase, PA-phosphatase related
M1S43_RS19580	COG0861	Integral membrane protein TerC family
M1S43_RS19590	COG0754	glutathionylspermidine amidase activity
M1S43_RS19600	COG0402	S-adenosylhomocysteine deaminase activity
M1S43_RS19615	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S43_RS19620	COG1230	cation diffusion facilitator family transporter
M1S43_RS19635	COG0706	membrane insertase activity
M1S43_RS19655	COG1192	Involved in chromosome partitioning
M1S43_RS19730	COG1061	Type III restriction enzyme res subunit
M1S43_RS19740	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S43_RS19745	COG1192	Involved in chromosome partitioning
M1S43_RS19810	COG0484	heat shock protein binding
M1S43_RS19940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S43_RS20060	COG1525	nuclease
M1S43_RS20145	COG0358	DNA primase activity
M1S43_RS20200	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S43_RS20245	COG0587	DNA-directed DNA polymerase activity
M1S43_RS20260	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1S43_RS20260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1S43_RS20310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M1S43_RS20310	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S43_RS20315	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S43_RS20355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S43_RS20400	COG1309	transcriptional regulator
M1S43_RS20410	COG1902	pentaerythritol trinitrate reductase activity
M1S43_RS20420	COG1979	alcohol dehydrogenase
M1S43_RS20435	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
M1S43_RS20460	COG1063	alcohol dehydrogenase
M1S43_RS20540	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S43_RS20560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system