locus-tag	class	description
M1S18_RS00010	COG0592	DNA-directed DNA polymerase activity
M1S18_RS00020	COG0187	DNA topoisomerase II activity
M1S18_RS00030	COG0586	Pfam SNARE associated Golgi protein
M1S18_RS00035	COG0488	(ABC) transporter
M1S18_RS00060	COG0596	Alpha beta hydrolase
M1S18_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M1S18_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M1S18_RS00115	COG0733	neurotransmitter:sodium symporter activity
M1S18_RS00155	COG2233	PERMEase
M1S18_RS00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S18_RS00205	COG2814	Major facilitator Superfamily
M1S18_RS00210	COG0656	L-ascorbic acid biosynthetic process
M1S18_RS00215	COG0583	DNA-binding transcription factor activity
M1S18_RS00230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S18_RS00235	COG1064	alcohol dehydrogenase
M1S18_RS00240	COG2818	Glycosylase
M1S18_RS00255	COG1194	a g-specific adenine glycosylase
M1S18_RS00275	COG2983	Belongs to the UPF0260 family
M1S18_RS00280	COG2133	pyrroloquinoline quinone binding
M1S18_RS00285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M1S18_RS00290	COG2116	formate transmembrane transporter activity
M1S18_RS00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S18_RS00315	COG1335	isochorismatase
M1S18_RS00320	COG0385	Bile acid
M1S18_RS00325	COG0534	Mate efflux family protein
M1S18_RS00330	COG1683	Conserved Protein
M1S18_RS00350	COG0625	glutathione transferase activity
M1S18_RS00360	COG1113	amino acid transport
M1S18_RS00370	COG0523	cobalamin synthesis protein
M1S18_RS00380	COG2188	Transcriptional regulator
M1S18_RS00410	COG0010	Belongs to the arginase family
M1S18_RS00425	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S18_RS00430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1S18_RS00440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M1S18_RS00445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M1S18_RS00545	COG0534	Mate efflux family protein
M1S18_RS00550	COG0436	Aminotransferase
M1S18_RS00555	COG2733	membrane
M1S18_RS00570	COG2918	glutathione biosynthetic process
M1S18_RS00585	COG0791	NLP P60 protein
M1S18_RS00585	COG1388	LysM domain
M1S18_RS00600	COG3150	esterase
M1S18_RS00610	COG1028	Short-chain dehydrogenase reductase Sdr
M1S18_RS00615	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
M1S18_RS00625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S18_RS00635	COG2233	PERMEase
M1S18_RS00640	COG2351	hydroxyisourate hydrolase activity
M1S18_RS00675	COG3706	GGDEF domain
M1S18_RS00690	COG1393	Belongs to the ArsC family
M1S18_RS00695	COG0708	Exodeoxyribonuclease III
M1S18_RS00715	COG0189	ligase activity
M1S18_RS00735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M1S18_RS00745	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M1S18_RS00760	COG4942	peptidase
M1S18_RS00770	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S18_RS00780	COG2119	membrane
M1S18_RS00785	COG4774	siderophore transport
M1S18_RS00790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S18_RS00790	COG0426	domain, Protein
M1S18_RS00815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M1S18_RS00835	COG1902	pentaerythritol trinitrate reductase activity
M1S18_RS00840	COG1519	Transferase
M1S18_RS00845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S18_RS00850	COG0668	transmembrane transport
M1S18_RS00860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S18_RS00865	COG1335	isochorismatase
M1S18_RS00870	COG1522	sequence-specific DNA binding
M1S18_RS00875	COG3328	transposase activity
M1S18_RS00900	COG0784	Response regulator, receiver
M1S18_RS00900	COG2205	protein histidine kinase activity
M1S18_RS00900	COG2198	Histidine kinase
M1S18_RS00905	COG3162	membrane
M1S18_RS00910	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S18_RS00920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S18_RS00940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M1S18_RS00945	COG1309	transcriptional regulator
M1S18_RS00965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S18_RS00965	COG0352	thiamine-phosphate diphosphorylase activity
M1S18_RS00965	COG0351	phosphomethylpyrimidine kinase
M1S18_RS00975	COG2814	Major facilitator Superfamily
M1S18_RS00990	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S18_RS01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S18_RS01015	COG1012	belongs to the aldehyde dehydrogenase family
M1S18_RS01025	COG1335	isochorismatase
M1S18_RS01055	COG2814	Major facilitator Superfamily
M1S18_RS01060	COG0583	DNA-binding transcription factor activity
M1S18_RS01080	COG0667	Aldo Keto reductase
M1S18_RS01115	COG1733	regulation of RNA biosynthetic process
M1S18_RS01120	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S18_RS01185	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M1S18_RS01200	COG2329	Antibiotic biosynthesis monooxygenase
M1S18_RS01230	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M1S18_RS01260	COG0427	acetyl-CoA hydrolase
M1S18_RS01285	COG0659	secondary active sulfate transmembrane transporter activity
M1S18_RS01290	COG4221	oxidoreductase activity
M1S18_RS01295	COG2873	o-acetylhomoserine
M1S18_RS01300	COG0488	(ABC) transporter
M1S18_RS01385	COG0833	amino acid
M1S18_RS01430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M1S18_RS01435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M1S18_RS01450	COG2226	methyltransferase
M1S18_RS01500	COG0067	glutamate synthase
M1S18_RS01500	COG0070	glutamate synthase
M1S18_RS01500	COG0069	glutamate synthase activity
M1S18_RS01505	COG0493	'glutamate synthase
M1S18_RS01515	COG1704	LemA family
M1S18_RS01520	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M1S18_RS01540	COG3307	-O-antigen
M1S18_RS01565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S18_RS01580	COG0194	GDP metabolic process
M1S18_RS01630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M1S18_RS01650	COG5380	lipid catabolic process
M1S18_RS01655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M1S18_RS01680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M1S18_RS01685	COG0277	FAD linked oxidase domain protein
M1S18_RS01695	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M1S18_RS01700	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S18_RS01715	COG1289	transmembrane transporter activity
M1S18_RS01725	COG0628	permease
M1S18_RS01730	COG1192	Involved in chromosome partitioning
M1S18_RS01760	COG0833	amino acid
M1S18_RS01765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S18_RS01770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S18_RS01780	COG1012	belongs to the aldehyde dehydrogenase family
M1S18_RS01820	COG0583	DNA-binding transcription factor activity
M1S18_RS01870	COG1983	PspC domain protein
M1S18_RS01895	COG0408	coproporphyrinogen oxidase activity
M1S18_RS01915	COG0513	Belongs to the DEAD box helicase family
M1S18_RS01925	COG1127	ABC transporter
M1S18_RS01930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M1S18_RS01940	COG2854	intermembrane phospholipid transfer
M1S18_RS01950	COG0598	Magnesium transport protein CorA
M1S18_RS01960	COG0494	nUDIX hydrolase
M1S18_RS01965	COG1040	competence protein
M1S18_RS01970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M1S18_RS01990	COG1946	Acyl-CoA thioesterase
M1S18_RS01995	COG1301	dicarboxylic acid transport
M1S18_RS02010	COG1959	2 iron, 2 sulfur cluster binding
M1S18_RS02015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S18_RS02015	COG1017	nitric oxide dioxygenase activity
M1S18_RS02020	COG0433	COG0433 Predicted ATPase
M1S18_RS02025	COG0626	cystathionine gamma-synthase activity
M1S18_RS02180	COG1960	acyl-CoA dehydrogenase activity
M1S18_RS02185	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M1S18_RS02215	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
M1S18_RS02220	COG0339	signal peptide processing
M1S18_RS02225	COG0557	exoribonuclease II activity
M1S18_RS02270	COG0179	Fumarylacetoacetate (FAA) hydrolase
M1S18_RS02275	COG2169	Transcriptional regulator
M1S18_RS02280	COG0697	spore germination
M1S18_RS02285	COG1295	ribonuclease BN
M1S18_RS02320	COG1702	phosphate starvation-inducible protein PhoH
M1S18_RS02330	COG0739	heme binding
M1S18_RS02330	COG0741	lytic transglycosylase activity
M1S18_RS02330	COG1196	nuclear chromosome segregation
M1S18_RS02360	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M1S18_RS02365	COG1183	phosphatidylcholine synthase activity
M1S18_RS02410	COG1960	acyl-CoA dehydrogenase activity
M1S18_RS02415	COG1309	transcriptional regulator
M1S18_RS02430	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S18_RS02435	COG1960	acyl-CoA dehydrogenase activity
M1S18_RS02455	COG2969	positive regulation of protein catabolic process
M1S18_RS02465	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M1S18_RS02480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M1S18_RS02485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M1S18_RS02505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M1S18_RS02515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S18_RS02520	COG1408	metallophosphoesterase
M1S18_RS02530	COG2199	diguanylate cyclase activity
M1S18_RS02590	COG1607	acyl-coa hydrolase
M1S18_RS02620	COG2350	Protein conserved in bacteria
M1S18_RS02630	COG0613	PHP domain protein
M1S18_RS02635	COG3781	membrane
M1S18_RS02645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M1S18_RS02650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1S18_RS02660	COG1862	Preprotein translocase
M1S18_RS02690	COG2205	protein histidine kinase activity
M1S18_RS02695	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M1S18_RS02715	COG0726	polysaccharide deacetylase
M1S18_RS02720	COG0463	Glycosyl transferase, family 2
M1S18_RS02725	COG0438	transferase activity, transferring glycosyl groups
M1S18_RS02790	COG0625	glutathione transferase activity
M1S18_RS02795	COG0583	DNA-binding transcription factor activity
M1S18_RS02800	COG1960	acyl-CoA dehydrogenase activity
M1S18_RS02805	COG1960	acyl-CoA dehydrogenase activity
M1S18_RS02815	COG2205	protein histidine kinase activity
M1S18_RS02820	COG0745	RESPONSE REGULATOR receiver
M1S18_RS02825	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M1S18_RS02845	COG2096	Adenosyltransferase
M1S18_RS02895	COG0285	dihydrofolate synthase activity
M1S18_RS02915	COG0450	alkyl hydroperoxide reductase
M1S18_RS02930	COG0477	Major facilitator Superfamily
M1S18_RS02935	COG1272	protein, Hemolysin III
M1S18_RS02965	COG0183	Belongs to the thiolase family
M1S18_RS02970	COG2207	Transcriptional regulator
M1S18_RS02990	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S18_RS03010	COG0183	Belongs to the thiolase family
M1S18_RS03020	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M1S18_RS03020	COG2885	chlorophyll binding
M1S18_RS03030	COG1690	Belongs to the RtcB family
M1S18_RS03035	COG0833	amino acid
M1S18_RS03045	COG2233	PERMEase
M1S18_RS03050	COG1217	gtp-binding protein TYPA
M1S18_RS03075	COG2094	Belongs to the DNA glycosylase MPG family
M1S18_RS03095	COG1902	pentaerythritol trinitrate reductase activity
M1S18_RS03110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S18_RS03115	COG0354	folic acid binding
M1S18_RS03125	COG3189	MarR family transcriptional regulator
M1S18_RS03130	COG2824	Alkylphosphonate utilization operon protein PhnA
M1S18_RS03135	COG3422	double-strand break repair
M1S18_RS03175	COG0840	transmembrane signaling receptor activity
M1S18_RS03195	COG5510	response to toxic substance
M1S18_RS03205	COG2832	Protein of unknown function (DUF454)
M1S18_RS03210	COG1376	ErfK ybiS ycfS ynhG family protein
M1S18_RS03250	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M1S18_RS03260	COG1289	transmembrane transporter activity
M1S18_RS03265	COG2814	Major facilitator Superfamily
M1S18_RS03285	COG1115	amino acid carrier protein
M1S18_RS03290	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S18_RS03295	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S18_RS03300	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
M1S18_RS03330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S18_RS03340	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S18_RS03345	COG1077	Cell shape determining protein MreB Mrl
M1S18_RS03350	COG1792	Involved in formation and maintenance of cell shape
M1S18_RS03355	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M1S18_RS03360	COG0424	maF-like protein
M1S18_RS03365	COG1530	ribonuclease E activity
M1S18_RS03375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S18_RS03385	COG0560	Phosphoserine phosphatase
M1S18_RS03395	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S18_RS03420	COG2207	Transcriptional regulator
M1S18_RS03440	COG1113	amino acid transport
M1S18_RS03445	COG2828	Protein conserved in bacteria
M1S18_RS03450	COG0142	geranyltranstransferase activity
M1S18_RS03455	COG2315	Protein conserved in bacteria
M1S18_RS03470	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S18_RS03495	COG0745	RESPONSE REGULATOR receiver
M1S18_RS03500	COG0642	Histidine kinase
M1S18_RS03510	COG0004	ammonium transporteR
M1S18_RS03515	COG0583	DNA-binding transcription factor activity
M1S18_RS03535	COG0525	valine-tRNA ligase activity
M1S18_RS03545	COG1028	Short-chain dehydrogenase reductase Sdr
M1S18_RS03555	COG0393	Putative heavy-metal-binding
M1S18_RS03560	COG0393	Putative heavy-metal-binding
M1S18_RS03565	COG1538	Outer membrane efflux protein
M1S18_RS03575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S18_RS03580	COG0671	phosphoesterase, PA-phosphatase related
M1S18_RS03610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M1S18_RS03625	COG1648	precorrin-2 dehydrogenase activity
M1S18_RS03625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M1S18_RS03630	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M1S18_RS03635	COG1733	regulation of RNA biosynthetic process
M1S18_RS03645	COG0531	amino acid
M1S18_RS03660	COG0321	lipoyl(octanoyl) transferase activity
M1S18_RS03665	COG2921	Belongs to the UPF0250 family
M1S18_RS03705	COG2009	succinate dehydrogenase
M1S18_RS03710	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M1S18_RS03715	COG1053	succinate dehydrogenase
M1S18_RS03720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M1S18_RS03745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S18_RS03765	COG2354	Protein conserved in bacteria
M1S18_RS03790	COG2843	Capsule synthesis protein
M1S18_RS03805	COG0589	response to stress
M1S18_RS03830	COG0505	Belongs to the CarA family
M1S18_RS03855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S18_RS03860	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M1S18_RS03910	COG0477	Major facilitator Superfamily
M1S18_RS03915	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M1S18_RS03930	COG1597	lipid kinase activity
M1S18_RS03935	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S18_RS03965	COG0584	glycerophosphoryl diester phosphodiesterase
M1S18_RS03985	COG0741	lytic transglycosylase activity
M1S18_RS04005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M1S18_RS04020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S18_RS04050	COG0778	Nitroreductase
M1S18_RS04065	COG1929	Belongs to the glycerate kinase type-1 family
M1S18_RS04070	COG0243	molybdopterin cofactor binding
M1S18_RS04075	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M1S18_RS04080	COG3339	Conserved Protein
M1S18_RS04090	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M1S18_RS04105	COG1113	amino acid transport
M1S18_RS04115	COG0019	diaminopimelate decarboxylase activity
M1S18_RS04125	COG1280	lysine exporter protein (LysE YggA)
M1S18_RS04130	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S18_RS04160	COG0463	Glycosyl transferase, family 2
M1S18_RS04180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S18_RS04215	COG4591	ABC-type transport system involved in lipoprotein release permease component
M1S18_RS04220	COG1136	(ABC) transporter
M1S18_RS04225	COG0658	competence protein
M1S18_RS04225	COG2333	competence protein COMEC
M1S18_RS04235	COG0616	signal peptide processing
M1S18_RS04235	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M1S18_RS04240	COG0596	Alpha beta hydrolase
M1S18_RS04245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M1S18_RS04255	COG0628	permease
M1S18_RS04290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S18_RS04310	COG0823	Involved in the tonB-independent uptake of proteins
M1S18_RS04335	COG1473	amidohydrolase
M1S18_RS04355	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M1S18_RS04355	COG0047	phosphoribosylformylglycinamidine synthase activity
M1S18_RS04360	COG2814	Major facilitator Superfamily
M1S18_RS04370	COG1024	Enoyl-CoA hydratase
M1S18_RS04375	COG1051	belongs to the nudix hydrolase family
M1S18_RS04375	COG1056	cytidyltransferase-related domain
M1S18_RS04385	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1S18_RS04400	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M1S18_RS04415	COG4625	pathogenesis
M1S18_RS04420	COG0583	DNA-binding transcription factor activity
M1S18_RS04425	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M1S18_RS04430	COG4208	sulfate ABC transporter
M1S18_RS04435	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M1S18_RS04445	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M1S18_RS04450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1S18_RS04455	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M1S18_RS04475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S18_RS04490	COG0681	Belongs to the peptidase S26 family
M1S18_RS04505	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M1S18_RS04515	COG1381	Involved in DNA repair and RecF pathway recombination
M1S18_RS04520	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M1S18_RS04530	COG4221	oxidoreductase activity
M1S18_RS04560	COG0436	Aminotransferase
M1S18_RS04580	COG0556	nucleotide-excision repair
M1S18_RS04635	COG2070	2-Nitropropane dioxygenase
M1S18_RS04665	COG1215	transferase activity, transferring glycosyl groups
M1S18_RS04680	COG0415	Belongs to the DNA photolyase family
M1S18_RS04690	COG1252	NADH dehydrogenase
M1S18_RS04695	COG1686	Belongs to the peptidase S11 family
M1S18_RS04710	COG1187	pseudouridine synthase activity
M1S18_RS04735	COG0477	Major facilitator Superfamily
M1S18_RS04740	COG0583	DNA-binding transcription factor activity
M1S18_RS04755	COG0612	Peptidase, M16
M1S18_RS04780	COG0352	thiamine-phosphate diphosphorylase activity
M1S18_RS04815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S18_RS04830	COG1309	transcriptional regulator
M1S18_RS04840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S18_RS04845	COG0076	glutamate decarboxylase activity
M1S18_RS04855	COG1522	sequence-specific DNA binding
M1S18_RS04860	COG3961	Belongs to the TPP enzyme family
M1S18_RS04865	COG1113	amino acid transport
M1S18_RS04870	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S18_RS04875	COG0573	inorganic phosphate transmembrane transporter activity
M1S18_RS04885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M1S18_RS04890	COG0616	signal peptide processing
M1S18_RS04925	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M1S18_RS04930	COG1686	Belongs to the peptidase S11 family
M1S18_RS04955	COG0583	DNA-binding transcription factor activity
M1S18_RS04960	COG1067	ATP-dependent peptidase activity
M1S18_RS05005	COG1966	Carbon starvation protein
M1S18_RS05010	COG2879	small protein
M1S18_RS05045	COG2508	Transcriptional regulator
M1S18_RS05045	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M1S18_RS05065	COG1113	amino acid transport
M1S18_RS05070	COG0583	DNA-binding transcription factor activity
M1S18_RS05075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S18_RS05080	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S18_RS05090	COG1012	belongs to the aldehyde dehydrogenase family
M1S18_RS05100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S18_RS05105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S18_RS05105	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M1S18_RS05140	COG2814	Major facilitator Superfamily
M1S18_RS05145	COG4948	Mandelate Racemase Muconate Lactonizing
M1S18_RS05155	COG1309	transcriptional regulator
M1S18_RS05175	COG1741	Belongs to the pirin family
M1S18_RS05185	COG2964	Protein conserved in bacteria
M1S18_RS05200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S18_RS05205	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S18_RS05210	COG4605	iron ion homeostasis
M1S18_RS05215	COG4604	ABC transporter, ATP-binding protein
M1S18_RS05220	COG4607	ABC-type enterochelin transport system periplasmic component
M1S18_RS05225	COG4774	siderophore transport
M1S18_RS05235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S18_RS05240	COG1021	2,3-dihydroxybenzoate-AMP ligase
M1S18_RS05245	COG1535	isochorismatase
M1S18_RS05245	COG3433	isochorismatase activity
M1S18_RS05260	COG1132	(ABC) transporter
M1S18_RS05265	COG1132	(ABC) transporter
M1S18_RS05270	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M1S18_RS05280	COG1169	isochorismate synthase
M1S18_RS05295	COG3739	integral membrane protein
M1S18_RS05320	COG0302	gtp cyclohydrolase
M1S18_RS05330	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M1S18_RS05360	COG0308	aminopeptidase N
M1S18_RS05365	COG0512	Glutamine amidotransferase of anthranilate synthase
M1S18_RS05380	COG0174	glutamine synthetase
M1S18_RS05390	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M1S18_RS05425	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1S18_RS05430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M1S18_RS05435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S18_RS05455	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S18_RS05460	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M1S18_RS05465	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M1S18_RS05480	COG1960	acyl-CoA dehydrogenase activity
M1S18_RS05485	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S18_RS05490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S18_RS05500	COG2223	nitrite transmembrane transporter activity
M1S18_RS05510	COG0024	Methionine aminopeptidase
M1S18_RS05515	COG0052	Belongs to the universal ribosomal protein uS2 family
M1S18_RS05530	COG2207	Transcriptional regulator
M1S18_RS05555	COG2951	lytic endotransglycosylase activity
M1S18_RS05560	COG0772	Belongs to the SEDS family
M1S18_RS05575	COG0842	Transport permease protein
M1S18_RS05580	COG1131	(ABC) transporter
M1S18_RS05625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S18_RS05640	COG4215	(ABC) transporter
M1S18_RS05645	COG4160	amino acid transport
M1S18_RS05650	COG4598	ABC transporter
M1S18_RS05660	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S18_RS05665	COG0826	peptidase U32
M1S18_RS05670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S18_RS05685	COG1720	tRNA m6t6A37 methyltransferase activity
M1S18_RS05695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M1S18_RS05710	COG0642	Histidine kinase
M1S18_RS05720	COG0494	nUDIX hydrolase
M1S18_RS05730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1S18_RS05735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M1S18_RS05740	COG3139	Protein of unknown function (DUF1315)
M1S18_RS05745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M1S18_RS05750	COG1301	dicarboxylic acid transport
M1S18_RS05755	COG1960	acyl-CoA dehydrogenase activity
M1S18_RS05760	COG2819	hydrolase of the alpha beta superfamily
M1S18_RS05770	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M1S18_RS05780	COG2195	Cleaves the N-terminal amino acid of tripeptides
M1S18_RS05785	COG1234	tRNA 3'-trailer cleavage
M1S18_RS05815	COG2363	Small membrane protein
M1S18_RS05840	COG0513	Belongs to the DEAD box helicase family
M1S18_RS05850	COG0778	Nitroreductase
M1S18_RS06205	COG1286	toxin biosynthetic process
M1S18_RS06230	COG4783	chaperone-mediated protein folding
M1S18_RS06235	COG1610	YqeY-like protein
M1S18_RS06380	COG0488	(ABC) transporter
M1S18_RS06385	COG3173	Aminoglycoside phosphotransferase
M1S18_RS06435	COG1301	dicarboxylic acid transport
M1S18_RS06445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S18_RS06450	COG2011	ABC-type metal ion transport system permease component
M1S18_RS06455	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S18_RS06460	COG1464	Belongs to the NlpA lipoprotein family
M1S18_RS06465	COG0151	Belongs to the GarS family
M1S18_RS06470	COG0138	bifunctional purine biosynthesis protein purh
M1S18_RS06475	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M1S18_RS06505	COG2308	Evidence 4 Homologs of previously reported genes of
M1S18_RS06515	COG1305	Transglutaminase-like
M1S18_RS06525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M1S18_RS06530	COG0305	Participates in initiation and elongation during chromosome replication
M1S18_RS06555	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M1S18_RS06565	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M1S18_RS06570	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M1S18_RS06595	COG1649	PFAM Uncharacterised BCR, COG1649
M1S18_RS06595	COG0726	polysaccharide deacetylase
M1S18_RS06600	COG1215	transferase activity, transferring glycosyl groups
M1S18_RS06605	COG3658	cytochrome
M1S18_RS06615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S18_RS06630	COG0583	DNA-binding transcription factor activity
M1S18_RS06650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S18_RS06655	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S18_RS06670	COG1960	acyl-CoA dehydrogenase activity
M1S18_RS06675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S18_RS06680	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S18_RS06705	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M1S18_RS06710	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M1S18_RS06720	COG2205	protein histidine kinase activity
M1S18_RS06725	COG0745	RESPONSE REGULATOR receiver
M1S18_RS06730	COG0174	glutamine synthetase
M1S18_RS06750	COG0729	surface antigen
M1S18_RS06775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S18_RS06780	COG2814	Major facilitator Superfamily
M1S18_RS06795	COG0583	DNA-binding transcription factor activity
M1S18_RS06810	COG1187	pseudouridine synthase activity
M1S18_RS06830	COG0802	atpase or kinase
M1S18_RS06835	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M1S18_RS06845	COG1923	regulation of RNA biosynthetic process
M1S18_RS06850	COG0697	spore germination
M1S18_RS06865	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S18_RS06875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S18_RS06880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S18_RS06880	COG0519	Catalyzes the synthesis of GMP from XMP
M1S18_RS06885	COG4302	ethanolamine ammonia-lyase activity
M1S18_RS06890	COG4303	Ethanolamine ammonia lyase large subunit
M1S18_RS06895	COG0531	amino acid
M1S18_RS06915	COG1454	alcohol dehydrogenase
M1S18_RS06920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S18_RS06930	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M1S18_RS06950	COG0308	aminopeptidase N
M1S18_RS06960	COG4221	oxidoreductase activity
M1S18_RS06970	COG1605	Chorismate mutase
M1S18_RS06990	COG1309	transcriptional regulator
M1S18_RS07000	COG0668	transmembrane transport
M1S18_RS07035	COG4773	Receptor
M1S18_RS07055	COG0488	(ABC) transporter
M1S18_RS07060	COG0589	response to stress
M1S18_RS07085	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M1S18_RS07095	COG3135	benzoate transporter
M1S18_RS07100	COG1522	sequence-specific DNA binding
M1S18_RS07110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M1S18_RS07115	COG0583	DNA-binding transcription factor activity
M1S18_RS07125	COG0183	Belongs to the thiolase family
M1S18_RS07135	COG2030	dehydratase
M1S18_RS07140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S18_RS07155	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M1S18_RS07165	COG0824	Thioesterase
M1S18_RS07170	COG1454	alcohol dehydrogenase
M1S18_RS07180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M1S18_RS07200	COG0069	glutamate synthase activity
M1S18_RS07375	COG5410	chromosome segregation
M1S18_RS07515	COG1196	nuclear chromosome segregation
M1S18_RS07515	COG0739	heme binding
M1S18_RS07515	COG0741	lytic transglycosylase activity
M1S18_RS07585	COG2814	Major facilitator Superfamily
M1S18_RS07600	COG0511	ligase activity, forming carbon-carbon bonds
M1S18_RS07620	COG1116	anion transmembrane transporter activity
M1S18_RS07620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S18_RS07625	COG0745	RESPONSE REGULATOR receiver
M1S18_RS07635	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S18_RS07635	COG2146	nitrite reductase [NAD(P)H] activity
M1S18_RS07640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S18_RS07645	COG0243	molybdopterin cofactor binding
M1S18_RS07655	COG0243	molybdopterin cofactor binding
M1S18_RS07660	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1S18_RS07675	COG0521	Mo-molybdopterin cofactor biosynthetic process
M1S18_RS07675	COG0315	cyclic pyranopterin monophosphate synthase activity
M1S18_RS07680	COG0303	'Molybdopterin
M1S18_RS07690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S18_RS07695	COG0697	spore germination
M1S18_RS07715	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M1S18_RS07720	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S18_RS07785	COG2204	response regulator
M1S18_RS07790	COG3852	Histidine kinase
M1S18_RS07810	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1S18_RS07815	COG0575	Belongs to the CDS family
M1S18_RS07850	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S18_RS07865	COG2137	regulation of response to DNA damage stimulus
M1S18_RS07875	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M1S18_RS07880	COG1011	Hydrolase
M1S18_RS07905	COG1522	sequence-specific DNA binding
M1S18_RS07915	COG1113	amino acid transport
M1S18_RS07935	COG0659	secondary active sulfate transmembrane transporter activity
M1S18_RS07940	COG2135	peptidase activity
M1S18_RS07955	COG5001	Diguanylate cyclase
M1S18_RS07955	COG3300	MHYT domain
M1S18_RS07975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S18_RS07975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S18_RS07975	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M1S18_RS07980	COG1105	Belongs to the carbohydrate kinase PfkB family
M1S18_RS07985	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S18_RS07985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1S18_RS08015	COG0024	Methionine aminopeptidase
M1S18_RS08020	COG0583	DNA-binding transcription factor activity
M1S18_RS08030	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M1S18_RS08035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S18_RS08040	COG0517	IMP dehydrogenase activity
M1S18_RS08040	COG0516	GMP reductase activity
M1S18_RS08065	COG0552	protein localization to endoplasmic reticulum
M1S18_RS08075	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M1S18_RS08090	COG4890	Cyd operon protein YbgT
M1S18_RS08095	COG1294	oxidase, subunit
M1S18_RS08110	COG1585	Membrane protein implicated in regulation of membrane protease activity
M1S18_RS08120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1S18_RS08125	COG4774	siderophore transport
M1S18_RS08140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1S18_RS08145	COG0569	domain protein
M1S18_RS08150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S18_RS08180	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M1S18_RS08185	COG0542	response to heat
M1S18_RS08210	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S18_RS08210	COG1902	pentaerythritol trinitrate reductase activity
M1S18_RS08255	COG2323	membrane
M1S18_RS08260	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M1S18_RS08270	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S18_RS08275	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S18_RS08280	COG0183	Belongs to the thiolase family
M1S18_RS08285	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M1S18_RS08290	COG0596	Alpha beta hydrolase
M1S18_RS08295	COG2271	Major facilitator Superfamily
M1S18_RS08300	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S18_RS08305	COG3485	protocatechuate 3,4-dioxygenase
M1S18_RS08310	COG3485	protocatechuate 3,4-dioxygenase
M1S18_RS08315	COG0710	3-dehydroquinate dehydratase activity
M1S18_RS08320	COG3420	alginic acid biosynthetic process
M1S18_RS08325	COG3659	wide pore channel activity
M1S18_RS08330	COG4993	Dehydrogenase
M1S18_RS08340	COG2391	methyltransferase activity
M1S18_RS08355	COG1414	Transcriptional regulator
M1S18_RS08360	COG0583	DNA-binding transcription factor activity
M1S18_RS08365	COG1960	acyl-CoA dehydrogenase activity
M1S18_RS08390	COG2814	Major facilitator Superfamily
M1S18_RS08400	COG0154	amidase activity
M1S18_RS08420	COG4638	Rieske (2fe-2S)
M1S18_RS08430	COG1028	Short-chain dehydrogenase reductase Sdr
M1S18_RS08440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S18_RS08450	COG3733	amine oxidase
M1S18_RS08460	COG1012	belongs to the aldehyde dehydrogenase family
M1S18_RS08470	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S18_RS08475	COG0183	Belongs to the thiolase family
M1S18_RS08480	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S18_RS08485	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S18_RS08495	COG4829	muconolactone delta-isomerase
M1S18_RS08500	COG4948	Mandelate Racemase Muconate Lactonizing
M1S18_RS08505	COG0583	DNA-binding transcription factor activity
M1S18_RS08515	COG2186	Transcriptional regulator
M1S18_RS08535	COG1012	belongs to the aldehyde dehydrogenase family
M1S18_RS08555	COG1960	acyl-CoA dehydrogenase activity
M1S18_RS08560	COG1028	Short-chain dehydrogenase reductase Sdr
M1S18_RS08565	COG3829	transcription factor binding
M1S18_RS08575	COG3162	membrane
M1S18_RS08590	COG1012	belongs to the aldehyde dehydrogenase family
M1S18_RS08605	COG0753	catalase activity
M1S18_RS08625	COG1846	Transcriptional regulator
M1S18_RS08630	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S18_RS08630	COG1902	pentaerythritol trinitrate reductase activity
M1S18_RS08640	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M1S18_RS08670	COG1309	transcriptional regulator
M1S18_RS08680	COG1335	isochorismatase
M1S18_RS08685	COG0583	DNA-binding transcription factor activity
M1S18_RS08705	COG1538	Outer membrane efflux protein
M1S18_RS08715	COG2072	flavoprotein involved in K transport
M1S18_RS08735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S18_RS08755	COG3539	Fimbrial protein
M1S18_RS08785	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M1S18_RS08795	COG0753	catalase activity
M1S18_RS08810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S18_RS08870	COG3433	isochorismatase activity
M1S18_RS08870	COG1535	isochorismatase
M1S18_RS08875	COG1028	Short-chain dehydrogenase reductase Sdr
M1S18_RS08880	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M1S18_RS08885	COG4149	molybdate abc transporter
M1S18_RS08890	COG0725	ABC transporter, periplasmic molybdate-binding protein
M1S18_RS08900	COG4638	Rieske (2fe-2S)
M1S18_RS08905	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S18_RS08910	COG0543	2 iron, 2 sulfur cluster binding
M1S18_RS08910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S18_RS08935	COG1028	Short-chain dehydrogenase reductase Sdr
M1S18_RS08950	COG2207	Transcriptional regulator
M1S18_RS08960	COG1028	Short-chain dehydrogenase reductase Sdr
M1S18_RS08965	COG2610	gluconate transmembrane transporter activity
M1S18_RS08975	COG0583	DNA-binding transcription factor activity
M1S18_RS08985	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S18_RS08990	COG2031	fatty acid transporter
M1S18_RS08995	COG0183	Belongs to the thiolase family
M1S18_RS09000	COG0583	DNA-binding transcription factor activity
M1S18_RS09005	COG0583	DNA-binding transcription factor activity
M1S18_RS09030	COG0477	Major facilitator Superfamily
M1S18_RS09050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S18_RS09055	COG4521	taurine ABC transporter
M1S18_RS09070	COG2188	Transcriptional regulator
M1S18_RS09080	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M1S18_RS09085	COG1733	regulation of RNA biosynthetic process
M1S18_RS09090	COG2207	Transcriptional regulator
M1S18_RS09090	COG3708	Transcriptional regulator
M1S18_RS09105	COG0730	response to heat
M1S18_RS09120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S18_RS09120	COG3453	Protein conserved in bacteria
M1S18_RS09130	COG3781	membrane
M1S18_RS09135	COG1063	alcohol dehydrogenase
M1S18_RS09145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S18_RS09150	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S18_RS09155	COG0022	dehydrogenase e1 component
M1S18_RS09160	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1S18_RS09165	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S18_RS09180	COG3706	GGDEF domain
M1S18_RS09195	COG0133	tryptophan synthase activity
M1S18_RS09205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S18_RS09240	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M1S18_RS09265	COG2226	methyltransferase
M1S18_RS09320	COG0842	Transport permease protein
M1S18_RS09325	COG0842	Transport permease protein
M1S18_RS09330	COG1131	(ABC) transporter
M1S18_RS09345	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S18_RS09350	COG4773	Receptor
M1S18_RS09370	COG0730	response to heat
M1S18_RS09375	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M1S18_RS09395	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M1S18_RS09410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S18_RS09450	COG4264	IucA IucC family
M1S18_RS09455	COG4264	IucA IucC family
M1S18_RS09460	COG2814	Major facilitator Superfamily
M1S18_RS09475	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M1S18_RS09490	COG1960	acyl-CoA dehydrogenase activity
M1S18_RS09495	COG1960	acyl-CoA dehydrogenase activity
M1S18_RS09500	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S18_RS09505	COG2207	Transcriptional regulator
M1S18_RS09510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S18_RS09515	COG0776	regulation of translation
M1S18_RS09540	COG0822	iron-sulfur transferase activity
M1S18_RS09545	COG0316	Belongs to the HesB IscA family
M1S18_RS09575	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S18_RS09595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S18_RS09600	COG0702	epimerase
M1S18_RS09635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1S18_RS09645	COG0339	signal peptide processing
M1S18_RS09695	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M1S18_RS09700	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M1S18_RS09730	COG0776	regulation of translation
M1S18_RS09795	COG0084	hydrolase, TatD family'
M1S18_RS09815	COG1663	tetraacyldisaccharide 4'-kinase activity
M1S18_RS09820	COG1132	(ABC) transporter
M1S18_RS09830	COG0811	peptide transport
M1S18_RS09835	COG1475	DNA binding
M1S18_RS09840	COG1192	Involved in chromosome partitioning
M1S18_RS09850	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M1S18_RS09865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S18_RS09870	COG0191	fructose-bisphosphate aldolase activity
M1S18_RS09890	COG0424	maF-like protein
M1S18_RS09895	COG2850	peptidyl-arginine hydroxylation
M1S18_RS09905	COG0640	Transcriptional regulator
M1S18_RS09915	COG3619	membrane
M1S18_RS09920	COG3122	Protein conserved in bacteria
M1S18_RS09925	COG1132	(ABC) transporter
M1S18_RS09945	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M1S18_RS09950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S18_RS09960	COG0506	proline dehydrogenase activity
M1S18_RS09960	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S18_RS09960	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S18_RS09965	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M1S18_RS09980	COG3698	Phosphodiester glycosidase
M1S18_RS09990	COG2353	YceI-like domain
M1S18_RS10000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M1S18_RS10050	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M1S18_RS10050	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M1S18_RS10075	COG3539	Fimbrial protein
M1S18_RS10080	COG3121	Chaperone
M1S18_RS10105	COG0697	spore germination
M1S18_RS10115	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S18_RS10125	COG0583	DNA-binding transcription factor activity
M1S18_RS10145	COG1309	transcriptional regulator
M1S18_RS10160	COG1522	sequence-specific DNA binding
M1S18_RS10175	COG1126	abc transporter atp-binding protein
M1S18_RS10180	COG0765	amino acid transport
M1S18_RS10185	COG0765	amino acid transport
M1S18_RS10215	COG1464	Belongs to the NlpA lipoprotein family
M1S18_RS10225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S18_RS10230	COG2011	ABC-type metal ion transport system permease component
M1S18_RS10235	COG0012	GTP binding
M1S18_RS10260	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S18_RS10300	COG0386	Belongs to the glutathione peroxidase family
M1S18_RS10310	COG0436	Aminotransferase
M1S18_RS10365	COG0583	DNA-binding transcription factor activity
M1S18_RS10370	COG0798	PFAM Bile acid sodium symporter
M1S18_RS10375	COG0640	Transcriptional regulator
M1S18_RS10390	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M1S18_RS10400	COG0583	DNA-binding transcription factor activity
M1S18_RS10410	COG1953	Uracil, thiamine, allantoin
M1S18_RS10420	COG2175	clavaminate synthase activity
M1S18_RS10425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S18_RS10430	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M1S18_RS10435	COG4521	taurine ABC transporter
M1S18_RS10445	COG0477	Major facilitator Superfamily
M1S18_RS10465	COG1271	oxidase subunit
M1S18_RS10470	COG1294	oxidase, subunit
M1S18_RS10480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S18_RS10500	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M1S18_RS10520	COG3052	prosthetic group binding
M1S18_RS10525	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
M1S18_RS10535	COG2814	Major facilitator Superfamily
M1S18_RS10555	COG1346	cytolysis
M1S18_RS10565	COG0583	DNA-binding transcription factor activity
M1S18_RS10570	COG0625	glutathione transferase activity
M1S18_RS10575	COG0625	glutathione transferase activity
M1S18_RS10580	COG0583	DNA-binding transcription factor activity
M1S18_RS10595	COG1045	serine acetyltransferase
M1S18_RS10600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S18_RS10605	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M1S18_RS10615	COG1280	lysine exporter protein (LysE YggA)
M1S18_RS10630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S18_RS10635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S18_RS10640	COG1126	abc transporter atp-binding protein
M1S18_RS10645	COG0765	amino acid transport
M1S18_RS10650	COG0765	amino acid transport
M1S18_RS10670	COG0784	Response regulator, receiver
M1S18_RS10670	COG2205	protein histidine kinase activity
M1S18_RS10690	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S18_RS10710	COG1028	Short-chain dehydrogenase reductase Sdr
M1S18_RS10760	COG0583	DNA-binding transcription factor activity
M1S18_RS10780	COG0318	PFAM AMP-dependent synthetase and ligase
M1S18_RS10785	COG1309	transcriptional regulator
M1S18_RS10790	COG1960	acyl-CoA dehydrogenase activity
M1S18_RS10795	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S18_RS10800	COG1024	Enoyl-CoA hydratase
M1S18_RS10805	COG4770	biotin carboxylase activity
M1S18_RS10815	COG0583	DNA-binding transcription factor activity
M1S18_RS10830	COG1960	acyl-CoA dehydrogenase activity
M1S18_RS10840	COG2814	Major facilitator Superfamily
M1S18_RS10850	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S18_RS10855	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S18_RS10860	COG2814	Major facilitator Superfamily
M1S18_RS10865	COG1960	acyl-CoA dehydrogenase activity
M1S18_RS10870	COG1024	Enoyl-CoA hydratase
M1S18_RS10875	COG1028	Short-chain dehydrogenase reductase Sdr
M1S18_RS10880	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S18_RS10885	COG0183	Belongs to the thiolase family
M1S18_RS10895	COG2814	Major facilitator Superfamily
M1S18_RS10905	COG1024	Enoyl-CoA hydratase
M1S18_RS10920	COG1960	acyl-CoA dehydrogenase activity
M1S18_RS10925	COG2814	Major facilitator Superfamily
M1S18_RS10930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S18_RS10935	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M1S18_RS10950	COG3842	ATPase activity
M1S18_RS10955	COG1840	ABC-type Fe3 transport system, periplasmic component
M1S18_RS10965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S18_RS10970	COG1414	Transcriptional regulator
M1S18_RS10980	COG0583	DNA-binding transcription factor activity
M1S18_RS10985	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S18_RS10990	COG1012	belongs to the aldehyde dehydrogenase family
M1S18_RS11000	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S18_RS11010	COG1012	belongs to the aldehyde dehydrogenase family
M1S18_RS11015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S18_RS11020	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S18_RS11025	COG2267	carboxylic ester hydrolase activity
M1S18_RS11045	COG3038	cytochrome b561
M1S18_RS11050	COG0753	catalase activity
M1S18_RS11085	COG2050	protein possibly involved in aromatic compounds catabolism
M1S18_RS11095	COG3327	negative regulation of DNA-templated transcription, initiation
M1S18_RS11100	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
M1S18_RS11105	COG0183	Belongs to the thiolase family
M1S18_RS11110	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S18_RS11115	COG1024	Enoyl-CoA hydratase
M1S18_RS11120	COG1024	Enoyl-CoA hydratase
M1S18_RS11125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S18_RS11130	COG2151	metal-sulfur cluster biosynthetic enzyme
M1S18_RS11135	COG3396	Phenylacetate-CoA oxygenase
M1S18_RS11140	COG3460	Phenylacetate-CoA oxygenase
M1S18_RS11145	COG3396	Phenylacetate-CoA oxygenase
M1S18_RS11150	COG1012	belongs to the aldehyde dehydrogenase family
M1S18_RS11150	COG2030	dehydratase
M1S18_RS11155	COG1760	l-serine dehydratase
M1S18_RS11160	COG0531	amino acid
M1S18_RS11165	COG1012	belongs to the aldehyde dehydrogenase family
M1S18_RS11180	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S18_RS11190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S18_RS11210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S18_RS11220	COG0789	Transcriptional regulator
M1S18_RS11235	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M1S18_RS11250	COG2807	transmembrane transport
M1S18_RS11255	COG0590	tRNA wobble adenosine to inosine editing
M1S18_RS11375	COG1116	anion transmembrane transporter activity
M1S18_RS11380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S18_RS11390	COG0864	Transcriptional regulator
M1S18_RS11410	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S18_RS11415	COG0439	Biotin carboxylase
M1S18_RS11430	COG1063	alcohol dehydrogenase
M1S18_RS11440	COG1309	transcriptional regulator
M1S18_RS11460	COG0038	chloride channel
M1S18_RS11465	COG4770	biotin carboxylase activity
M1S18_RS11485	COG1914	H( )-stimulated, divalent metal cation uptake system
M1S18_RS11490	COG0583	DNA-binding transcription factor activity
M1S18_RS11540	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S18_RS11560	COG2814	Major facilitator Superfamily
M1S18_RS11575	COG1560	Kdo2-lipid A biosynthetic process
M1S18_RS11585	COG5006	permease, DMT superfamily
M1S18_RS11590	COG1522	sequence-specific DNA binding
M1S18_RS11605	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M1S18_RS11615	COG4122	O-methyltransferase activity
M1S18_RS11645	COG1538	Outer membrane efflux protein
M1S18_RS11650	COG1137	ATPase activity
M1S18_RS11655	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M1S18_RS11665	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M1S18_RS11670	COG0517	IMP dehydrogenase activity
M1S18_RS11670	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M1S18_RS11705	COG2814	Major facilitator Superfamily
M1S18_RS11740	COG1278	Cold shock
M1S18_RS11745	COG1280	lysine exporter protein (LysE YggA)
M1S18_RS11775	COG1570	exodeoxyribonuclease VII activity
M1S18_RS11825	COG0583	DNA-binding transcription factor activity
M1S18_RS11835	COG4638	Rieske (2fe-2S)
M1S18_RS11840	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S18_RS11845	COG0543	2 iron, 2 sulfur cluster binding
M1S18_RS11845	COG0633	Ferredoxin
M1S18_RS11850	COG1028	Short-chain dehydrogenase reductase Sdr
M1S18_RS11855	COG3135	benzoate transporter
M1S18_RS11860	COG2814	Major facilitator Superfamily
M1S18_RS11875	COG1643	Atp-dependent helicase
M1S18_RS11880	COG0450	alkyl hydroperoxide reductase
M1S18_RS11890	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M1S18_RS11900	COG3634	alkyl hydroperoxide reductase activity
M1S18_RS11925	COG0625	glutathione transferase activity
M1S18_RS11935	COG2885	chlorophyll binding
M1S18_RS11970	COG0542	response to heat
M1S18_RS11985	COG1765	OsmC-like protein
M1S18_RS12005	COG0667	Aldo Keto reductase
M1S18_RS12020	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M1S18_RS12030	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M1S18_RS12040	COG0527	aspartate kinase activity
M1S18_RS12050	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M1S18_RS12060	COG3038	cytochrome b561
M1S18_RS12065	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M1S18_RS12070	COG2252	PERMEase
M1S18_RS12080	COG2072	flavoprotein involved in K transport
M1S18_RS12095	COG1741	Belongs to the pirin family
M1S18_RS12190	COG0300	oxidoreductase activity
M1S18_RS12210	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M1S18_RS12245	COG2072	flavoprotein involved in K transport
M1S18_RS12250	COG0300	oxidoreductase activity
M1S18_RS12270	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M1S18_RS12320	COG1012	belongs to the aldehyde dehydrogenase family
M1S18_RS12340	COG0531	amino acid
M1S18_RS12350	COG1113	amino acid transport
M1S18_RS12390	COG3209	COG3209 Rhs family protein
M1S18_RS12420	COG4269	membrane
M1S18_RS12435	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S18_RS12435	COG1902	pentaerythritol trinitrate reductase activity
M1S18_RS12445	COG2203	Gaf domain
M1S18_RS12445	COG3706	GGDEF domain
M1S18_RS12445	COG4251	negative regulation of phosphorylation
M1S18_RS12445	COG5001	Diguanylate cyclase
M1S18_RS12455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S18_RS12475	COG4172	Belongs to the ABC transporter superfamily
M1S18_RS12480	COG4239	(ABC) transporter, permease
M1S18_RS12485	COG4174	ABC transporter (Permease)
M1S18_RS12495	COG0741	lytic transglycosylase activity
M1S18_RS12495	COG0741	lytic transglycosylase activity
M1S18_RS12495	COG1388	LysM domain
M1S18_RS12495	COG1388	LysM domain
M1S18_RS12500	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S18_RS12540	COG0583	DNA-binding transcription factor activity
M1S18_RS12545	COG1279	arginine transmembrane transporter activity
M1S18_RS12565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S18_RS12570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S18_RS12575	COG0006	proline dipeptidase activity
M1S18_RS12660	COG0741	lytic transglycosylase activity
M1S18_RS12660	COG1196	nuclear chromosome segregation
M1S18_RS12660	COG0739	heme binding
M1S18_RS12720	COG4695	Portal protein
M1S18_RS12820	COG0305	Participates in initiation and elongation during chromosome replication
M1S18_RS12835	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S18_RS12895	COG2194	sulfuric ester hydrolase activity
M1S18_RS12940	COG0739	heme binding
M1S18_RS13265	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M1S18_RS13290	COG3384	dioxygenase
M1S18_RS13300	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S18_RS13305	COG2878	Part of a membrane complex involved in electron transport
M1S18_RS13310	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M1S18_RS13335	COG0768	penicillin binding
M1S18_RS13340	COG0742	ribosomal rna small subunit methyltransferase
M1S18_RS13355	COG0830	nickel cation binding
M1S18_RS13365	COG0804	urea catabolic process
M1S18_RS13405	COG1253	flavin adenine dinucleotide binding
M1S18_RS13410	COG2851	Citrate transporter
M1S18_RS13460	COG1773	rubredoxin
M1S18_RS13465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S18_RS13500	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M1S18_RS13505	COG4181	ATPase activity
M1S18_RS13550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M1S18_RS13570	COG0306	phosphate transporter
M1S18_RS13580	COG3958	Transketolase
M1S18_RS13585	COG3959	Transketolase, thiamine diphosphate binding domain
M1S18_RS13590	COG2271	Major facilitator Superfamily
M1S18_RS13595	COG1028	Short-chain dehydrogenase reductase Sdr
M1S18_RS13600	COG0583	DNA-binding transcription factor activity
M1S18_RS13615	COG2223	nitrite transmembrane transporter activity
M1S18_RS13620	COG2207	Transcriptional regulator
M1S18_RS13625	COG2066	Belongs to the glutaminase family
M1S18_RS13630	COG0242	peptide deformylase activity
M1S18_RS13635	COG0477	Major facilitator Superfamily
M1S18_RS13645	COG0028	Belongs to the TPP enzyme family
M1S18_RS13660	COG1028	Short-chain dehydrogenase reductase Sdr
M1S18_RS13665	COG2267	carboxylic ester hydrolase activity
M1S18_RS13675	COG2271	Major facilitator Superfamily
M1S18_RS13680	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S18_RS13690	COG1028	Short-chain dehydrogenase reductase Sdr
M1S18_RS13710	COG1414	Transcriptional regulator
M1S18_RS13725	COG1024	Enoyl-CoA hydratase
M1S18_RS13735	COG1215	transferase activity, transferring glycosyl groups
M1S18_RS13740	COG0726	polysaccharide deacetylase
M1S18_RS13740	COG1649	PFAM Uncharacterised BCR, COG1649
M1S18_RS13750	COG4681	YaeQ
M1S18_RS13760	COG0523	cobalamin synthesis protein
M1S18_RS13770	COG1607	acyl-coa hydrolase
M1S18_RS13780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S18_RS13785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S18_RS13790	COG1309	transcriptional regulator
M1S18_RS13815	COG2040	homocysteine
M1S18_RS13820	COG0531	amino acid
M1S18_RS13875	COG1595	DNA-templated transcription, initiation
M1S18_RS13885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S18_RS13890	COG0477	Major facilitator Superfamily
M1S18_RS13910	COG0084	hydrolase, TatD family'
M1S18_RS13945	COG0629	single-stranded DNA binding
M1S18_RS14000	COG0582	viral genome integration into host DNA
M1S18_RS14090	COG0592	DNA-directed DNA polymerase activity
M1S18_RS14130	COG2026	Addiction module toxin, RelE StbE family
M1S18_RS14280	COG3755	Protein conserved in bacteria
M1S18_RS14325	COG1484	DNA-dependent DNA replication
M1S18_RS14415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S18_RS14485	COG0405	Gamma-glutamyltransferase
M1S18_RS14490	COG2814	Major facilitator Superfamily
M1S18_RS14500	COG2050	protein possibly involved in aromatic compounds catabolism
M1S18_RS14515	COG1090	epimerase
M1S18_RS14535	COG0420	3'-5' exonuclease activity
M1S18_RS14560	COG0735	belongs to the Fur family
M1S18_RS14565	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M1S18_RS14585	COG0121	glutamine amidotransferase
M1S18_RS14600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S18_RS14610	COG0210	DNA helicase
M1S18_RS14615	COG2885	chlorophyll binding
M1S18_RS14620	COG0204	Acyl-transferase
M1S18_RS14635	COG2894	cell division
M1S18_RS14655	COG1280	lysine exporter protein (LysE YggA)
M1S18_RS14660	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M1S18_RS14660	COG1674	ftsk spoiiie
M1S18_RS14665	COG0492	ferredoxin-NADP+ reductase activity
M1S18_RS14670	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M1S18_RS14680	COG0456	acetyltransferase
M1S18_RS14725	COG1981	membrane
M1S18_RS14740	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M1S18_RS14740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S18_RS14760	COG1012	belongs to the aldehyde dehydrogenase family
M1S18_RS14770	COG0657	acetylesterase activity
M1S18_RS14780	COG0473	3-isopropylmalate dehydrogenase activity
M1S18_RS14785	COG0583	DNA-binding transcription factor activity
M1S18_RS14805	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S18_RS14830	COG0564	pseudouridine synthase activity
M1S18_RS14840	COG0358	DNA primase activity
M1S18_RS14855	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M1S18_RS14885	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S18_RS14915	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M1S18_RS14925	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S18_RS14925	COG0351	phosphomethylpyrimidine kinase
M1S18_RS14925	COG0352	thiamine-phosphate diphosphorylase activity
M1S18_RS14930	COG1652	LysM domain
M1S18_RS14955	COG1399	metal-binding, possibly nucleic acid-binding protein
M1S18_RS14960	COG3101	peptidyl-lysine hydroxylation
M1S18_RS14965	COG0009	L-threonylcarbamoyladenylate synthase
M1S18_RS14970	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M1S18_RS14975	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M1S18_RS14990	COG4106	trans-aconitate 2-methyltransferase activity
M1S18_RS15005	COG0596	Alpha beta hydrolase
M1S18_RS15005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S18_RS15005	COG2226	methyltransferase
M1S18_RS15010	COG1877	trehalose-phosphatase activity
M1S18_RS15015	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
M1S18_RS15020	COG2223	nitrite transmembrane transporter activity
M1S18_RS15040	COG1196	nuclear chromosome segregation
M1S18_RS15050	COG0730	response to heat
M1S18_RS15065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M1S18_RS15075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S18_RS15125	COG0489	protein tyrosine kinase activity
M1S18_RS15135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S18_RS15135	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S18_RS15165	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M1S18_RS15170	COG2081	HI0933 family
M1S18_RS15180	COG0668	transmembrane transport
M1S18_RS15200	COG0583	DNA-binding transcription factor activity
M1S18_RS15220	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1S18_RS15225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S18_RS15255	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M1S18_RS15295	COG0745	RESPONSE REGULATOR receiver
M1S18_RS15315	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S18_RS15325	COG2205	protein histidine kinase activity
M1S18_RS15395	COG4993	Dehydrogenase
M1S18_RS15420	COG0384	phenazine biosynthesis protein PhzF
M1S18_RS15445	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S18_RS15460	COG0583	DNA-binding transcription factor activity
M1S18_RS15490	COG0583	DNA-binding transcription factor activity
M1S18_RS15505	COG0583	DNA-binding transcription factor activity
M1S18_RS15510	COG1053	succinate dehydrogenase
M1S18_RS15520	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M1S18_RS15525	COG2814	Major facilitator Superfamily
M1S18_RS15530	COG1960	acyl-CoA dehydrogenase activity
M1S18_RS15535	COG0583	DNA-binding transcription factor activity
M1S18_RS15540	COG1063	alcohol dehydrogenase
M1S18_RS15570	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M1S18_RS15575	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M1S18_RS15580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S18_RS15595	COG3667	copper resistance
M1S18_RS15600	COG2132	Multicopper oxidase
M1S18_RS15610	COG0561	phosphatase activity
M1S18_RS15615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M1S18_RS15640	COG1214	PFAM Peptidase M22, glycoprotease
M1S18_RS15690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M1S18_RS15700	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M1S18_RS15705	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M1S18_RS15710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M1S18_RS15770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S18_RS15780	COG1846	Transcriptional regulator
M1S18_RS15785	COG1764	response to oxidative stress
M1S18_RS15825	COG0037	tRNA processing
M1S18_RS15835	COG0248	Ppx GppA phosphatase
M1S18_RS15865	COG0072	phenylalanine-tRNA ligase activity
M1S18_RS15910	COG1238	metal cluster binding
M1S18_RS15915	COG0625	glutathione transferase activity
M1S18_RS15930	COG0318	PFAM AMP-dependent synthetase and ligase
M1S18_RS15935	COG3028	Belongs to the UPF0307 family
M1S18_RS15940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S18_RS15960	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M1S18_RS15965	COG0617	tRNA 3'-terminal CCA addition
M1S18_RS15970	COG1555	photosystem II stabilization
M1S18_RS15975	COG3956	TIGRFAM MazG family protein
M1S18_RS15985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S18_RS16005	COG2205	protein histidine kinase activity
M1S18_RS16005	COG5002	protein histidine kinase activity
M1S18_RS16005	COG0784	Response regulator, receiver
M1S18_RS16010	COG1024	Enoyl-CoA hydratase
M1S18_RS16015	COG2084	Dehydrogenase
M1S18_RS16020	COG3622	Belongs to the hyi family
M1S18_RS16050	COG0697	spore germination
M1S18_RS16060	COG2814	Major facilitator Superfamily
M1S18_RS16065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S18_RS16075	COG0583	DNA-binding transcription factor activity
M1S18_RS16085	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M1S18_RS16100	COG0084	hydrolase, TatD family'
M1S18_RS16115	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M1S18_RS16145	COG0440	acetolactate synthase activity
M1S18_RS16150	COG0028	Belongs to the TPP enzyme family
M1S18_RS16175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S18_RS16180	COG1136	(ABC) transporter
M1S18_RS16180	COG0577	efflux transmembrane transporter activity
M1S18_RS16185	COG1538	Outer membrane efflux protein
M1S18_RS16200	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M1S18_RS16205	COG1162	GTPase activity
M1S18_RS16215	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M1S18_RS16235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M1S18_RS16240	COG1028	Short-chain dehydrogenase reductase Sdr
M1S18_RS16280	COG2986	histidine ammonia-lyase
M1S18_RS16295	COG0318	PFAM AMP-dependent synthetase and ligase
M1S18_RS16305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S18_RS16350	COG1426	Protein conserved in bacteria
M1S18_RS16385	COG0793	Belongs to the peptidase S41A family
M1S18_RS16400	COG2267	carboxylic ester hydrolase activity
M1S18_RS16410	COG1012	belongs to the aldehyde dehydrogenase family
M1S18_RS16415	COG3265	gluconokinase activity
M1S18_RS16425	COG0800	Aldolase
M1S18_RS16435	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M1S18_RS16440	COG0280	phosphate acetyltransferase
M1S18_RS16440	COG0857	belongs to the CobB CobQ family
M1S18_RS16445	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S18_RS16445	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S18_RS16465	COG0740	serine-type endopeptidase activity
M1S18_RS16475	COG4774	siderophore transport
M1S18_RS16485	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1S18_RS16495	COG2813	Specifically methylates the guanine in position
M1S18_RS16495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S18_RS16595	COG0788	formyltetrahydrofolate deformylase activity
M1S18_RS16620	COG4651	solute:proton antiporter activity
M1S18_RS16620	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S18_RS16640	COG0724	RNA recognition motif
M1S18_RS16645	COG0210	DNA helicase
M1S18_RS16670	COG1733	regulation of RNA biosynthetic process
M1S18_RS16680	COG2900	Belongs to the SlyX family
M1S18_RS16685	COG0488	(ABC) transporter
M1S18_RS16690	COG1280	lysine exporter protein (LysE YggA)
M1S18_RS16695	COG1560	Kdo2-lipid A biosynthetic process
M1S18_RS16705	COG1301	dicarboxylic acid transport
M1S18_RS16760	COG0473	3-isopropylmalate dehydrogenase activity
M1S18_RS16825	COG0583	DNA-binding transcription factor activity
M1S18_RS16835	COG0625	glutathione transferase activity
M1S18_RS16840	COG2378	regulation of single-species biofilm formation
M1S18_RS16845	COG0546	phosphoglycolate phosphatase activity
M1S18_RS16855	COG1530	ribonuclease E activity
M1S18_RS16860	COG0318	PFAM AMP-dependent synthetase and ligase
M1S18_RS16875	COG0583	DNA-binding transcription factor activity
M1S18_RS16880	COG4221	oxidoreductase activity
M1S18_RS16885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M1S18_RS16895	COG0534	Mate efflux family protein
M1S18_RS16910	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M1S18_RS16950	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M1S18_RS16955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S18_RS16970	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S18_RS16980	COG0644	oxidoreductase
M1S18_RS16980	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
M1S18_RS16985	COG0425	Belongs to the sulfur carrier protein TusA family
M1S18_RS16990	COG4535	Mg2 and Co2 transporter CorC
M1S18_RS17000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S18_RS17020	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M1S18_RS17025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S18_RS17025	COG0475	glutathione-regulated potassium exporter activity
M1S18_RS17030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M1S18_RS17040	COG0484	heat shock protein binding
M1S18_RS17045	COG0789	Transcriptional regulator
M1S18_RS17050	COG0598	Magnesium transport protein CorA
M1S18_RS17065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S18_RS17070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S18_RS17075	COG1074	ATP-dependent DNA helicase activity
M1S18_RS17080	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M1S18_RS17100	COG2226	methyltransferase
M1S18_RS17115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S18_RS17120	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M1S18_RS17135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S18_RS17135	COG2111	Na H antiporter
M1S18_RS17140	COG1006	Multisubunit Na H antiporter MnhC subunit
M1S18_RS17145	COG0651	ATP synthesis coupled electron transport
M1S18_RS17150	COG1863	multisubunit Na H antiporter MnhE subunit
M1S18_RS17155	COG2212	antiporter activity
M1S18_RS17160	COG1320	monovalent cation:proton antiporter activity
M1S18_RS17175	COG0195	Participates in both transcription termination and antitermination
M1S18_RS17225	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M1S18_RS17230	COG0237	dephospho-CoA kinase activity
M1S18_RS17240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S18_RS17255	COG0497	DNA recombination
M1S18_RS17265	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M1S18_RS17295	COG2169	Transcriptional regulator
M1S18_RS17295	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S18_RS17300	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M1S18_RS17365	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M1S18_RS17380	COG0326	Molecular chaperone. Has ATPase activity
M1S18_RS17395	COG2056	Na+-H+ antiporter family
M1S18_RS17400	COG0596	Alpha beta hydrolase
M1S18_RS17495	COG0546	phosphoglycolate phosphatase activity
M1S18_RS17500	COG1716	ATPase activity
M1S18_RS17545	COG0181	hydroxymethylbilane synthase activity
M1S18_RS17555	COG3275	phosphorelay sensor kinase activity
M1S18_RS17575	COG1538	Outer membrane efflux protein
M1S18_RS17580	COG0697	spore germination
M1S18_RS17605	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S18_RS17610	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M1S18_RS17615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S18_RS17620	COG0772	Belongs to the SEDS family
M1S18_RS17645	COG4974	Belongs to the 'phage' integrase family
M1S18_RS17650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S18_RS17660	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M1S18_RS17670	COG2197	response regulator
M1S18_RS17685	COG0793	Belongs to the peptidase S41A family
M1S18_RS17690	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M1S18_RS17695	COG0795	lipopolysaccharide-transporting ATPase activity
M1S18_RS17735	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S18_RS17735	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S18_RS17745	COG0004	ammonium transporteR
M1S18_RS17750	COG0347	Belongs to the P(II) protein family
M1S18_RS17810	COG0659	secondary active sulfate transmembrane transporter activity
M1S18_RS17815	COG0589	response to stress
M1S18_RS17855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S18_RS17900	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S18_RS17930	COG0659	secondary active sulfate transmembrane transporter activity
M1S18_RS17935	COG0589	response to stress
M1S18_RS17970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S18_RS17980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S18_RS18000	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M1S18_RS18015	COG0318	PFAM AMP-dependent synthetase and ligase
M1S18_RS18025	COG0477	Major facilitator Superfamily
M1S18_RS18030	COG2860	membrane
M1S18_RS18040	COG1253	flavin adenine dinucleotide binding
M1S18_RS18060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1S18_RS18100	COG0655	NAD(P)H dehydrogenase (quinone) activity
M1S18_RS18110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M1S18_RS18180	COG0758	DNA mediated transformation
M1S18_RS18190	COG0697	spore germination
M1S18_RS18195	COG1309	transcriptional regulator
M1S18_RS18210	COG0386	Belongs to the glutathione peroxidase family
M1S18_RS18275	COG1121	(ABC) transporter
M1S18_RS18280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1S18_RS18285	COG1280	lysine exporter protein (LysE YggA)
M1S18_RS18290	COG2837	iron assimilation
M1S18_RS18300	COG0281	malic enzyme
M1S18_RS18345	COG0519	Catalyzes the synthesis of GMP from XMP
M1S18_RS18345	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S18_RS18350	COG4399	Belongs to the UPF0754 family
M1S18_RS18355	COG2259	Doxx family
M1S18_RS18360	COG0586	Pfam SNARE associated Golgi protein
M1S18_RS18375	COG1192	Involved in chromosome partitioning
M1S18_RS18385	COG0271	Belongs to the BolA IbaG family
M1S18_RS18405	COG2267	carboxylic ester hydrolase activity
M1S18_RS18425	COG3321	synthase
M1S18_RS18425	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M1S18_RS18425	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M1S18_RS18425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S18_RS18430	COG1960	acyl-CoA dehydrogenase activity
M1S18_RS18440	COG2197	response regulator
M1S18_RS18450	COG3916	Acyl-homoserine-lactone synthase
M1S18_RS18455	COG0477	Major facilitator Superfamily
M1S18_RS18460	COG1024	Enoyl-CoA hydratase
M1S18_RS18465	COG1024	Enoyl-CoA hydratase
M1S18_RS18470	COG1960	acyl-CoA dehydrogenase activity
M1S18_RS18475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S18_RS18495	COG1113	amino acid transport
M1S18_RS18500	COG1113	amino acid transport
M1S18_RS18505	COG0251	oxidation-reduction process
M1S18_RS18545	COG0564	pseudouridine synthase activity
M1S18_RS18605	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M1S18_RS18620	COG1802	Transcriptional regulator
M1S18_RS18630	COG1448	Aminotransferase
M1S18_RS18635	COG0277	FAD linked oxidase domain protein
M1S18_RS18645	COG2186	Transcriptional regulator
M1S18_RS18655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S18_RS18660	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S18_RS18675	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M1S18_RS18680	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M1S18_RS18685	COG1216	Glycosyl transferase, family 2
M1S18_RS18715	COG2089	acid synthase
M1S18_RS18730	COG1083	cytidylyl-transferase
M1S18_RS18735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M1S18_RS18740	COG1086	Polysaccharide biosynthesis protein
M1S18_RS18745	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M1S18_RS18750	COG1596	polysaccharide export
M1S18_RS18775	COG0728	peptidoglycan biosynthetic process
M1S18_RS18780	COG3023	N-Acetylmuramoyl-L-alanine amidase
M1S18_RS18840	COG0546	phosphoglycolate phosphatase activity
M1S18_RS18845	COG1028	Short-chain dehydrogenase reductase Sdr
M1S18_RS18865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S18_RS18870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S18_RS18875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S18_RS18880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S18_RS18885	COG1116	anion transmembrane transporter activity
M1S18_RS18890	COG1309	transcriptional regulator
M1S18_RS18895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M1S18_RS18905	COG0196	riboflavin kinase activity
M1S18_RS18910	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M1S18_RS18920	COG1047	Peptidyl-prolyl cis-trans
M1S18_RS18960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M1S18_RS18965	COG0657	acetylesterase activity
M1S18_RS18985	COG0583	DNA-binding transcription factor activity
M1S18_RS19015	COG2951	lytic endotransglycosylase activity
M1S18_RS19020	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M1S18_RS19035	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M1S18_RS19045	COG0671	phosphoesterase, PA-phosphatase related
M1S18_RS19050	COG0861	Integral membrane protein TerC family
M1S18_RS19060	COG0754	glutathionylspermidine amidase activity
M1S18_RS19070	COG0402	S-adenosylhomocysteine deaminase activity
M1S18_RS19085	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S18_RS19090	COG1230	cation diffusion facilitator family transporter
M1S18_RS19105	COG0706	membrane insertase activity
M1S18_RS19140	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
M1S18_RS19210	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
M1S18_RS19265	COG1192	Involved in chromosome partitioning
M1S18_RS19340	COG1061	Type III restriction enzyme res subunit
M1S18_RS19350	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S18_RS19355	COG1192	Involved in chromosome partitioning
M1S18_RS19420	COG0484	heat shock protein binding
M1S18_RS19550	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S18_RS19670	COG1525	nuclease