locus-tag	class	description
M1S24_RS00010	COG0592	DNA-directed DNA polymerase activity
M1S24_RS00020	COG0187	DNA topoisomerase II activity
M1S24_RS00030	COG0586	Pfam SNARE associated Golgi protein
M1S24_RS00035	COG0488	(ABC) transporter
M1S24_RS00060	COG0596	Alpha beta hydrolase
M1S24_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M1S24_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M1S24_RS00110	COG0733	neurotransmitter:sodium symporter activity
M1S24_RS00150	COG2233	PERMEase
M1S24_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S24_RS00200	COG2814	Major facilitator Superfamily
M1S24_RS00205	COG0656	L-ascorbic acid biosynthetic process
M1S24_RS00210	COG0583	DNA-binding transcription factor activity
M1S24_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S24_RS00230	COG1064	alcohol dehydrogenase
M1S24_RS00235	COG2818	Glycosylase
M1S24_RS00250	COG1194	a g-specific adenine glycosylase
M1S24_RS00270	COG2983	Belongs to the UPF0260 family
M1S24_RS00275	COG2133	pyrroloquinoline quinone binding
M1S24_RS00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M1S24_RS00285	COG2116	formate transmembrane transporter activity
M1S24_RS00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S24_RS00310	COG1335	isochorismatase
M1S24_RS00315	COG0385	Bile acid
M1S24_RS00320	COG0534	Mate efflux family protein
M1S24_RS00325	COG1683	Conserved Protein
M1S24_RS00345	COG0625	glutathione transferase activity
M1S24_RS00355	COG1113	amino acid transport
M1S24_RS00365	COG0523	cobalamin synthesis protein
M1S24_RS00375	COG2188	Transcriptional regulator
M1S24_RS00405	COG0010	Belongs to the arginase family
M1S24_RS00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S24_RS00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1S24_RS00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M1S24_RS00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M1S24_RS00540	COG0534	Mate efflux family protein
M1S24_RS00545	COG0436	Aminotransferase
M1S24_RS00550	COG2733	membrane
M1S24_RS00565	COG2918	glutathione biosynthetic process
M1S24_RS00580	COG0791	NLP P60 protein
M1S24_RS00580	COG1388	LysM domain
M1S24_RS00595	COG3150	esterase
M1S24_RS00605	COG1028	Short-chain dehydrogenase reductase Sdr
M1S24_RS00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
M1S24_RS00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S24_RS00630	COG2233	PERMEase
M1S24_RS00635	COG2351	hydroxyisourate hydrolase activity
M1S24_RS00670	COG3706	GGDEF domain
M1S24_RS00685	COG1393	Belongs to the ArsC family
M1S24_RS00690	COG0708	Exodeoxyribonuclease III
M1S24_RS00710	COG0189	ligase activity
M1S24_RS00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M1S24_RS00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M1S24_RS00755	COG4942	peptidase
M1S24_RS00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S24_RS00775	COG2119	membrane
M1S24_RS00780	COG4774	siderophore transport
M1S24_RS00785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S24_RS00785	COG0426	domain, Protein
M1S24_RS00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M1S24_RS00830	COG1902	pentaerythritol trinitrate reductase activity
M1S24_RS00835	COG1519	Transferase
M1S24_RS00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S24_RS00845	COG0668	transmembrane transport
M1S24_RS00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S24_RS00860	COG1335	isochorismatase
M1S24_RS00865	COG1522	sequence-specific DNA binding
M1S24_RS00870	COG3328	transposase activity
M1S24_RS00900	COG2205	protein histidine kinase activity
M1S24_RS00900	COG2198	Histidine kinase
M1S24_RS00900	COG0784	Response regulator, receiver
M1S24_RS00905	COG3162	membrane
M1S24_RS00910	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S24_RS00920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S24_RS00940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M1S24_RS00945	COG1309	transcriptional regulator
M1S24_RS00965	COG0351	phosphomethylpyrimidine kinase
M1S24_RS00965	COG0352	thiamine-phosphate diphosphorylase activity
M1S24_RS00965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S24_RS00975	COG2814	Major facilitator Superfamily
M1S24_RS00990	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S24_RS01000	COG1113	amino acid transport
M1S24_RS01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S24_RS01015	COG1012	belongs to the aldehyde dehydrogenase family
M1S24_RS01025	COG1335	isochorismatase
M1S24_RS01055	COG2814	Major facilitator Superfamily
M1S24_RS01060	COG0583	DNA-binding transcription factor activity
M1S24_RS01080	COG0667	Aldo Keto reductase
M1S24_RS01115	COG1733	regulation of RNA biosynthetic process
M1S24_RS01120	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S24_RS01185	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M1S24_RS01200	COG2329	Antibiotic biosynthesis monooxygenase
M1S24_RS01230	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M1S24_RS01260	COG0427	acetyl-CoA hydrolase
M1S24_RS01285	COG0659	secondary active sulfate transmembrane transporter activity
M1S24_RS01290	COG4221	oxidoreductase activity
M1S24_RS01295	COG2873	o-acetylhomoserine
M1S24_RS01300	COG0488	(ABC) transporter
M1S24_RS01385	COG0833	amino acid
M1S24_RS01430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M1S24_RS01435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M1S24_RS01450	COG2226	methyltransferase
M1S24_RS01505	COG0493	'glutamate synthase
M1S24_RS01515	COG1704	LemA family
M1S24_RS01520	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M1S24_RS01540	COG3307	-O-antigen
M1S24_RS01565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S24_RS01580	COG0194	GDP metabolic process
M1S24_RS01630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M1S24_RS01650	COG5380	lipid catabolic process
M1S24_RS01655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M1S24_RS01680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M1S24_RS01685	COG0277	FAD linked oxidase domain protein
M1S24_RS01695	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M1S24_RS01700	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S24_RS01715	COG1289	transmembrane transporter activity
M1S24_RS01725	COG0628	permease
M1S24_RS01730	COG1192	Involved in chromosome partitioning
M1S24_RS01760	COG0833	amino acid
M1S24_RS01765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S24_RS01770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S24_RS01780	COG1012	belongs to the aldehyde dehydrogenase family
M1S24_RS01820	COG0583	DNA-binding transcription factor activity
M1S24_RS01865	COG0517	IMP dehydrogenase activity
M1S24_RS01870	COG1983	PspC domain protein
M1S24_RS01880	COG1960	acyl-CoA dehydrogenase activity
M1S24_RS01895	COG0408	coproporphyrinogen oxidase activity
M1S24_RS01915	COG0513	Belongs to the DEAD box helicase family
M1S24_RS01925	COG1127	ABC transporter
M1S24_RS01930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M1S24_RS01940	COG2854	intermembrane phospholipid transfer
M1S24_RS01950	COG0598	Magnesium transport protein CorA
M1S24_RS01960	COG0494	nUDIX hydrolase
M1S24_RS01965	COG1040	competence protein
M1S24_RS01970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M1S24_RS01990	COG1946	Acyl-CoA thioesterase
M1S24_RS01995	COG1301	dicarboxylic acid transport
M1S24_RS02010	COG1959	2 iron, 2 sulfur cluster binding
M1S24_RS02015	COG1017	nitric oxide dioxygenase activity
M1S24_RS02015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S24_RS02020	COG0433	COG0433 Predicted ATPase
M1S24_RS02025	COG0626	cystathionine gamma-synthase activity
M1S24_RS02180	COG1960	acyl-CoA dehydrogenase activity
M1S24_RS02185	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M1S24_RS02215	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
M1S24_RS02220	COG0339	signal peptide processing
M1S24_RS02225	COG0557	exoribonuclease II activity
M1S24_RS02270	COG0179	Fumarylacetoacetate (FAA) hydrolase
M1S24_RS02275	COG2169	Transcriptional regulator
M1S24_RS02280	COG0697	spore germination
M1S24_RS02285	COG1295	ribonuclease BN
M1S24_RS02320	COG1702	phosphate starvation-inducible protein PhoH
M1S24_RS02330	COG0739	heme binding
M1S24_RS02330	COG0741	lytic transglycosylase activity
M1S24_RS02330	COG1196	nuclear chromosome segregation
M1S24_RS02360	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M1S24_RS02365	COG1183	phosphatidylcholine synthase activity
M1S24_RS02410	COG1960	acyl-CoA dehydrogenase activity
M1S24_RS02415	COG1309	transcriptional regulator
M1S24_RS02430	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S24_RS02435	COG1960	acyl-CoA dehydrogenase activity
M1S24_RS02455	COG2969	positive regulation of protein catabolic process
M1S24_RS02465	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M1S24_RS02480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M1S24_RS02485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M1S24_RS02505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M1S24_RS02515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S24_RS02520	COG1408	metallophosphoesterase
M1S24_RS02530	COG2199	diguanylate cyclase activity
M1S24_RS02590	COG1607	acyl-coa hydrolase
M1S24_RS02620	COG2350	Protein conserved in bacteria
M1S24_RS02630	COG0613	PHP domain protein
M1S24_RS02635	COG3781	membrane
M1S24_RS02645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M1S24_RS02650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1S24_RS02660	COG1862	Preprotein translocase
M1S24_RS02690	COG2205	protein histidine kinase activity
M1S24_RS02695	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M1S24_RS02715	COG0726	polysaccharide deacetylase
M1S24_RS02720	COG0463	Glycosyl transferase, family 2
M1S24_RS02725	COG0438	transferase activity, transferring glycosyl groups
M1S24_RS02790	COG0625	glutathione transferase activity
M1S24_RS02795	COG0583	DNA-binding transcription factor activity
M1S24_RS02800	COG1960	acyl-CoA dehydrogenase activity
M1S24_RS02805	COG1960	acyl-CoA dehydrogenase activity
M1S24_RS02815	COG2205	protein histidine kinase activity
M1S24_RS02820	COG0745	RESPONSE REGULATOR receiver
M1S24_RS02825	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M1S24_RS02845	COG2096	Adenosyltransferase
M1S24_RS02895	COG0285	dihydrofolate synthase activity
M1S24_RS02915	COG0450	alkyl hydroperoxide reductase
M1S24_RS02930	COG0477	Major facilitator Superfamily
M1S24_RS02975	COG0183	Belongs to the thiolase family
M1S24_RS02980	COG2207	Transcriptional regulator
M1S24_RS03000	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S24_RS03020	COG0183	Belongs to the thiolase family
M1S24_RS03030	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M1S24_RS03030	COG2885	chlorophyll binding
M1S24_RS03040	COG1690	Belongs to the RtcB family
M1S24_RS03045	COG0833	amino acid
M1S24_RS03055	COG2233	PERMEase
M1S24_RS03060	COG1217	gtp-binding protein TYPA
M1S24_RS03085	COG2094	Belongs to the DNA glycosylase MPG family
M1S24_RS03105	COG1902	pentaerythritol trinitrate reductase activity
M1S24_RS03120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S24_RS03125	COG0354	folic acid binding
M1S24_RS03135	COG3189	MarR family transcriptional regulator
M1S24_RS03140	COG2824	Alkylphosphonate utilization operon protein PhnA
M1S24_RS03145	COG3422	double-strand break repair
M1S24_RS03185	COG0840	transmembrane signaling receptor activity
M1S24_RS03205	COG5510	response to toxic substance
M1S24_RS03215	COG2832	Protein of unknown function (DUF454)
M1S24_RS03220	COG1376	ErfK ybiS ycfS ynhG family protein
M1S24_RS03260	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M1S24_RS03270	COG1289	transmembrane transporter activity
M1S24_RS03275	COG2814	Major facilitator Superfamily
M1S24_RS03295	COG1115	amino acid carrier protein
M1S24_RS03300	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S24_RS03305	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S24_RS03310	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
M1S24_RS03340	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S24_RS03350	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S24_RS03355	COG1077	Cell shape determining protein MreB Mrl
M1S24_RS03360	COG1792	Involved in formation and maintenance of cell shape
M1S24_RS03365	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M1S24_RS03370	COG0424	maF-like protein
M1S24_RS03375	COG1530	ribonuclease E activity
M1S24_RS03385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S24_RS03395	COG0560	Phosphoserine phosphatase
M1S24_RS03405	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S24_RS03440	COG2207	Transcriptional regulator
M1S24_RS03460	COG1113	amino acid transport
M1S24_RS03465	COG2828	Protein conserved in bacteria
M1S24_RS03470	COG0142	geranyltranstransferase activity
M1S24_RS03475	COG2315	Protein conserved in bacteria
M1S24_RS03490	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S24_RS03515	COG0745	RESPONSE REGULATOR receiver
M1S24_RS03520	COG0642	Histidine kinase
M1S24_RS03530	COG0004	ammonium transporteR
M1S24_RS03535	COG0583	DNA-binding transcription factor activity
M1S24_RS03555	COG0525	valine-tRNA ligase activity
M1S24_RS03565	COG1028	Short-chain dehydrogenase reductase Sdr
M1S24_RS03575	COG0393	Putative heavy-metal-binding
M1S24_RS03580	COG0393	Putative heavy-metal-binding
M1S24_RS03585	COG1538	Outer membrane efflux protein
M1S24_RS03595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S24_RS03600	COG0671	phosphoesterase, PA-phosphatase related
M1S24_RS03630	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M1S24_RS03645	COG1648	precorrin-2 dehydrogenase activity
M1S24_RS03645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M1S24_RS03650	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M1S24_RS03655	COG1733	regulation of RNA biosynthetic process
M1S24_RS03665	COG0531	amino acid
M1S24_RS03680	COG0321	lipoyl(octanoyl) transferase activity
M1S24_RS03685	COG2921	Belongs to the UPF0250 family
M1S24_RS03725	COG2009	succinate dehydrogenase
M1S24_RS03730	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M1S24_RS03735	COG1053	succinate dehydrogenase
M1S24_RS03740	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M1S24_RS03765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S24_RS03785	COG2354	Protein conserved in bacteria
M1S24_RS03790	COG2321	neutral zinc metallopeptidase
M1S24_RS03810	COG2843	Capsule synthesis protein
M1S24_RS03825	COG0589	response to stress
M1S24_RS03845	COG0505	Belongs to the CarA family
M1S24_RS03870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S24_RS03875	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M1S24_RS03925	COG0477	Major facilitator Superfamily
M1S24_RS03930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M1S24_RS03945	COG1597	lipid kinase activity
M1S24_RS03950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S24_RS03980	COG0584	glycerophosphoryl diester phosphodiesterase
M1S24_RS04000	COG0741	lytic transglycosylase activity
M1S24_RS04020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M1S24_RS04035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S24_RS04065	COG0778	Nitroreductase
M1S24_RS04080	COG1929	Belongs to the glycerate kinase type-1 family
M1S24_RS04085	COG0243	molybdopterin cofactor binding
M1S24_RS04090	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M1S24_RS04095	COG3339	Conserved Protein
M1S24_RS04105	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M1S24_RS04120	COG1113	amino acid transport
M1S24_RS04130	COG0019	diaminopimelate decarboxylase activity
M1S24_RS04145	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S24_RS04175	COG0463	Glycosyl transferase, family 2
M1S24_RS04195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S24_RS04230	COG4591	ABC-type transport system involved in lipoprotein release permease component
M1S24_RS04235	COG1136	(ABC) transporter
M1S24_RS04240	COG0658	competence protein
M1S24_RS04240	COG2333	competence protein COMEC
M1S24_RS04250	COG0616	signal peptide processing
M1S24_RS04250	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M1S24_RS04255	COG0596	Alpha beta hydrolase
M1S24_RS04260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M1S24_RS04270	COG0628	permease
M1S24_RS04305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S24_RS04325	COG0823	Involved in the tonB-independent uptake of proteins
M1S24_RS04345	COG0824	Thioesterase
M1S24_RS04350	COG1473	amidohydrolase
M1S24_RS04370	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M1S24_RS04370	COG0047	phosphoribosylformylglycinamidine synthase activity
M1S24_RS04375	COG2814	Major facilitator Superfamily
M1S24_RS04385	COG1024	Enoyl-CoA hydratase
M1S24_RS04390	COG1051	belongs to the nudix hydrolase family
M1S24_RS04390	COG1056	cytidyltransferase-related domain
M1S24_RS04400	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1S24_RS04415	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M1S24_RS04430	COG4625	pathogenesis
M1S24_RS04435	COG0583	DNA-binding transcription factor activity
M1S24_RS04440	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M1S24_RS04445	COG4208	sulfate ABC transporter
M1S24_RS04450	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M1S24_RS04460	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M1S24_RS04465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1S24_RS04470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M1S24_RS04490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S24_RS04505	COG0681	Belongs to the peptidase S26 family
M1S24_RS04520	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M1S24_RS04530	COG1381	Involved in DNA repair and RecF pathway recombination
M1S24_RS04535	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M1S24_RS04545	COG4221	oxidoreductase activity
M1S24_RS04575	COG0436	Aminotransferase
M1S24_RS04595	COG0556	nucleotide-excision repair
M1S24_RS04650	COG2070	2-Nitropropane dioxygenase
M1S24_RS04680	COG1215	transferase activity, transferring glycosyl groups
M1S24_RS04695	COG0415	Belongs to the DNA photolyase family
M1S24_RS04705	COG1252	NADH dehydrogenase
M1S24_RS04710	COG1686	Belongs to the peptidase S11 family
M1S24_RS04725	COG1187	pseudouridine synthase activity
M1S24_RS04750	COG0477	Major facilitator Superfamily
M1S24_RS04755	COG0583	DNA-binding transcription factor activity
M1S24_RS04760	COG1823	symporter activity
M1S24_RS04770	COG0612	Peptidase, M16
M1S24_RS04795	COG0352	thiamine-phosphate diphosphorylase activity
M1S24_RS04830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S24_RS04845	COG1309	transcriptional regulator
M1S24_RS04855	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S24_RS04860	COG0076	glutamate decarboxylase activity
M1S24_RS04870	COG1522	sequence-specific DNA binding
M1S24_RS04875	COG3961	Belongs to the TPP enzyme family
M1S24_RS04880	COG1113	amino acid transport
M1S24_RS04885	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S24_RS04890	COG0573	inorganic phosphate transmembrane transporter activity
M1S24_RS04900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M1S24_RS04905	COG0616	signal peptide processing
M1S24_RS04940	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M1S24_RS04970	COG0583	DNA-binding transcription factor activity
M1S24_RS04975	COG1067	ATP-dependent peptidase activity
M1S24_RS05020	COG1966	Carbon starvation protein
M1S24_RS05025	COG2879	small protein
M1S24_RS05060	COG2508	Transcriptional regulator
M1S24_RS05060	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M1S24_RS05085	COG1113	amino acid transport
M1S24_RS05090	COG0583	DNA-binding transcription factor activity
M1S24_RS05095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S24_RS05100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S24_RS05110	COG1012	belongs to the aldehyde dehydrogenase family
M1S24_RS05120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S24_RS05125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S24_RS05125	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M1S24_RS05160	COG2814	Major facilitator Superfamily
M1S24_RS05165	COG4948	Mandelate Racemase Muconate Lactonizing
M1S24_RS05175	COG1309	transcriptional regulator
M1S24_RS05195	COG1741	Belongs to the pirin family
M1S24_RS05205	COG2964	Protein conserved in bacteria
M1S24_RS05220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S24_RS05230	COG4605	iron ion homeostasis
M1S24_RS05235	COG4604	ABC transporter, ATP-binding protein
M1S24_RS05240	COG4607	ABC-type enterochelin transport system periplasmic component
M1S24_RS05245	COG4774	siderophore transport
M1S24_RS05255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S24_RS05260	COG1021	2,3-dihydroxybenzoate-AMP ligase
M1S24_RS05265	COG3433	isochorismatase activity
M1S24_RS05265	COG1535	isochorismatase
M1S24_RS05280	COG1132	(ABC) transporter
M1S24_RS05285	COG1132	(ABC) transporter
M1S24_RS05290	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M1S24_RS05300	COG1169	isochorismate synthase
M1S24_RS05315	COG3739	integral membrane protein
M1S24_RS05340	COG0302	gtp cyclohydrolase
M1S24_RS05350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M1S24_RS05380	COG0308	aminopeptidase N
M1S24_RS05385	COG0512	Glutamine amidotransferase of anthranilate synthase
M1S24_RS05400	COG0174	glutamine synthetase
M1S24_RS05410	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M1S24_RS05445	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1S24_RS05450	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M1S24_RS05455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S24_RS05475	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S24_RS05480	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M1S24_RS05485	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M1S24_RS05500	COG1960	acyl-CoA dehydrogenase activity
M1S24_RS05505	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S24_RS05510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S24_RS05520	COG2223	nitrite transmembrane transporter activity
M1S24_RS05530	COG0024	Methionine aminopeptidase
M1S24_RS05535	COG0052	Belongs to the universal ribosomal protein uS2 family
M1S24_RS05550	COG2207	Transcriptional regulator
M1S24_RS05575	COG2951	lytic endotransglycosylase activity
M1S24_RS05580	COG0772	Belongs to the SEDS family
M1S24_RS05595	COG0842	Transport permease protein
M1S24_RS05600	COG1131	(ABC) transporter
M1S24_RS05645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S24_RS05660	COG4215	(ABC) transporter
M1S24_RS05665	COG4160	amino acid transport
M1S24_RS05670	COG4598	ABC transporter
M1S24_RS05680	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S24_RS05685	COG0826	peptidase U32
M1S24_RS05690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S24_RS05705	COG1720	tRNA m6t6A37 methyltransferase activity
M1S24_RS05715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M1S24_RS05730	COG0642	Histidine kinase
M1S24_RS05740	COG0494	nUDIX hydrolase
M1S24_RS05750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1S24_RS05755	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M1S24_RS05760	COG3139	Protein of unknown function (DUF1315)
M1S24_RS05765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M1S24_RS05770	COG1301	dicarboxylic acid transport
M1S24_RS05775	COG1960	acyl-CoA dehydrogenase activity
M1S24_RS05780	COG2819	hydrolase of the alpha beta superfamily
M1S24_RS05790	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M1S24_RS05800	COG2195	Cleaves the N-terminal amino acid of tripeptides
M1S24_RS05805	COG1234	tRNA 3'-trailer cleavage
M1S24_RS05835	COG2363	Small membrane protein
M1S24_RS05860	COG0513	Belongs to the DEAD box helicase family
M1S24_RS05870	COG0778	Nitroreductase
M1S24_RS06220	COG1286	toxin biosynthetic process
M1S24_RS06245	COG4783	chaperone-mediated protein folding
M1S24_RS06250	COG1610	YqeY-like protein
M1S24_RS06350	COG3111	PFAM Bacterial OB fold (BOF) protein
M1S24_RS06375	COG3243	poly(R)-hydroxyalkanoic acid synthase
M1S24_RS06380	COG0786	glutamate:sodium symporter activity
M1S24_RS06390	COG2186	Transcriptional regulator
M1S24_RS06440	COG0477	Major facilitator Superfamily
M1S24_RS06470	COG2985	domain, Protein
M1S24_RS06480	COG2995	paraquat-inducible protein a
M1S24_RS06485	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M1S24_RS06485	COG3008	intermembrane lipid transfer
M1S24_RS06510	COG1309	transcriptional regulator
M1S24_RS06515	COG1741	Belongs to the pirin family
M1S24_RS06530	COG2072	flavoprotein involved in K transport
M1S24_RS06540	COG2252	PERMEase
M1S24_RS06545	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M1S24_RS06550	COG3038	cytochrome b561
M1S24_RS06560	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M1S24_RS06570	COG0527	aspartate kinase activity
M1S24_RS06580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M1S24_RS06590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M1S24_RS06605	COG0667	Aldo Keto reductase
M1S24_RS06625	COG1765	OsmC-like protein
M1S24_RS06640	COG0542	response to heat
M1S24_RS06675	COG2885	chlorophyll binding
M1S24_RS06685	COG0625	glutathione transferase activity
M1S24_RS06690	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M1S24_RS06720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M1S24_RS06730	COG0450	alkyl hydroperoxide reductase
M1S24_RS06735	COG1643	Atp-dependent helicase
M1S24_RS06750	COG2814	Major facilitator Superfamily
M1S24_RS06755	COG3135	benzoate transporter
M1S24_RS06760	COG1028	Short-chain dehydrogenase reductase Sdr
M1S24_RS06765	COG0543	2 iron, 2 sulfur cluster binding
M1S24_RS06765	COG0633	Ferredoxin
M1S24_RS06770	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S24_RS06775	COG4638	Rieske (2fe-2S)
M1S24_RS06785	COG0583	DNA-binding transcription factor activity
M1S24_RS06835	COG1570	exodeoxyribonuclease VII activity
M1S24_RS06865	COG1280	lysine exporter protein (LysE YggA)
M1S24_RS06870	COG1278	Cold shock
M1S24_RS06905	COG2814	Major facilitator Superfamily
M1S24_RS06940	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M1S24_RS06940	COG0517	IMP dehydrogenase activity
M1S24_RS06945	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M1S24_RS06955	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M1S24_RS06960	COG1137	ATPase activity
M1S24_RS06965	COG1538	Outer membrane efflux protein
M1S24_RS06995	COG4122	O-methyltransferase activity
M1S24_RS07005	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M1S24_RS07020	COG1522	sequence-specific DNA binding
M1S24_RS07025	COG5006	permease, DMT superfamily
M1S24_RS07035	COG1560	Kdo2-lipid A biosynthetic process
M1S24_RS07050	COG2814	Major facilitator Superfamily
M1S24_RS07070	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S24_RS07120	COG0583	DNA-binding transcription factor activity
M1S24_RS07125	COG1914	H( )-stimulated, divalent metal cation uptake system
M1S24_RS07145	COG4770	biotin carboxylase activity
M1S24_RS07150	COG0038	chloride channel
M1S24_RS07180	COG1063	alcohol dehydrogenase
M1S24_RS07195	COG0439	Biotin carboxylase
M1S24_RS07200	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S24_RS07220	COG0864	Transcriptional regulator
M1S24_RS07230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S24_RS07235	COG1116	anion transmembrane transporter activity
M1S24_RS07355	COG0590	tRNA wobble adenosine to inosine editing
M1S24_RS07360	COG2807	transmembrane transport
M1S24_RS07375	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M1S24_RS07390	COG0789	Transcriptional regulator
M1S24_RS07400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S24_RS07420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S24_RS07430	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S24_RS07445	COG1012	belongs to the aldehyde dehydrogenase family
M1S24_RS07450	COG0531	amino acid
M1S24_RS07455	COG1760	l-serine dehydratase
M1S24_RS07460	COG2030	dehydratase
M1S24_RS07460	COG1012	belongs to the aldehyde dehydrogenase family
M1S24_RS07465	COG3396	Phenylacetate-CoA oxygenase
M1S24_RS07470	COG3460	Phenylacetate-CoA oxygenase
M1S24_RS07475	COG3396	Phenylacetate-CoA oxygenase
M1S24_RS07480	COG2151	metal-sulfur cluster biosynthetic enzyme
M1S24_RS07485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S24_RS07490	COG1024	Enoyl-CoA hydratase
M1S24_RS07495	COG1024	Enoyl-CoA hydratase
M1S24_RS07500	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S24_RS07505	COG0183	Belongs to the thiolase family
M1S24_RS07510	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
M1S24_RS07515	COG3327	negative regulation of DNA-templated transcription, initiation
M1S24_RS07525	COG2050	protein possibly involved in aromatic compounds catabolism
M1S24_RS07560	COG0753	catalase activity
M1S24_RS07565	COG3038	cytochrome b561
M1S24_RS07585	COG2267	carboxylic ester hydrolase activity
M1S24_RS07590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S24_RS07595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S24_RS07600	COG1012	belongs to the aldehyde dehydrogenase family
M1S24_RS07610	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S24_RS07620	COG1012	belongs to the aldehyde dehydrogenase family
M1S24_RS07625	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S24_RS07630	COG0583	DNA-binding transcription factor activity
M1S24_RS07640	COG1414	Transcriptional regulator
M1S24_RS07645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S24_RS07655	COG1840	ABC-type Fe3 transport system, periplasmic component
M1S24_RS07660	COG3842	ATPase activity
M1S24_RS07675	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M1S24_RS07680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S24_RS07685	COG2814	Major facilitator Superfamily
M1S24_RS07690	COG1960	acyl-CoA dehydrogenase activity
M1S24_RS07705	COG1024	Enoyl-CoA hydratase
M1S24_RS07715	COG2814	Major facilitator Superfamily
M1S24_RS07725	COG0183	Belongs to the thiolase family
M1S24_RS07730	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S24_RS07735	COG1028	Short-chain dehydrogenase reductase Sdr
M1S24_RS07740	COG1024	Enoyl-CoA hydratase
M1S24_RS07745	COG1960	acyl-CoA dehydrogenase activity
M1S24_RS07750	COG2814	Major facilitator Superfamily
M1S24_RS07755	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S24_RS07760	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S24_RS07770	COG2814	Major facilitator Superfamily
M1S24_RS07780	COG1960	acyl-CoA dehydrogenase activity
M1S24_RS07795	COG0583	DNA-binding transcription factor activity
M1S24_RS07805	COG4770	biotin carboxylase activity
M1S24_RS07810	COG1024	Enoyl-CoA hydratase
M1S24_RS07815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S24_RS07820	COG1960	acyl-CoA dehydrogenase activity
M1S24_RS07825	COG1309	transcriptional regulator
M1S24_RS07830	COG0318	PFAM AMP-dependent synthetase and ligase
M1S24_RS07855	COG0583	DNA-binding transcription factor activity
M1S24_RS07905	COG1028	Short-chain dehydrogenase reductase Sdr
M1S24_RS07925	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S24_RS07945	COG2205	protein histidine kinase activity
M1S24_RS07945	COG0784	Response regulator, receiver
M1S24_RS07965	COG0765	amino acid transport
M1S24_RS07970	COG0765	amino acid transport
M1S24_RS07975	COG1126	abc transporter atp-binding protein
M1S24_RS07980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S24_RS07985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S24_RS08000	COG1280	lysine exporter protein (LysE YggA)
M1S24_RS08010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M1S24_RS08015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S24_RS08020	COG1045	serine acetyltransferase
M1S24_RS08035	COG0583	DNA-binding transcription factor activity
M1S24_RS08040	COG0625	glutathione transferase activity
M1S24_RS08045	COG0625	glutathione transferase activity
M1S24_RS08050	COG0583	DNA-binding transcription factor activity
M1S24_RS08060	COG1346	cytolysis
M1S24_RS08080	COG2814	Major facilitator Superfamily
M1S24_RS08090	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
M1S24_RS08095	COG3052	prosthetic group binding
M1S24_RS08115	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M1S24_RS08135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S24_RS08145	COG1294	oxidase, subunit
M1S24_RS08150	COG1271	oxidase subunit
M1S24_RS08170	COG0477	Major facilitator Superfamily
M1S24_RS08180	COG4521	taurine ABC transporter
M1S24_RS08185	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M1S24_RS08190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S24_RS08195	COG2175	clavaminate synthase activity
M1S24_RS08215	COG0583	DNA-binding transcription factor activity
M1S24_RS08225	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M1S24_RS08240	COG0640	Transcriptional regulator
M1S24_RS08245	COG0798	PFAM Bile acid sodium symporter
M1S24_RS08250	COG0583	DNA-binding transcription factor activity
M1S24_RS08305	COG0436	Aminotransferase
M1S24_RS08315	COG0386	Belongs to the glutathione peroxidase family
M1S24_RS08355	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S24_RS08380	COG0012	GTP binding
M1S24_RS08385	COG2011	ABC-type metal ion transport system permease component
M1S24_RS08390	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S24_RS08400	COG1464	Belongs to the NlpA lipoprotein family
M1S24_RS08430	COG0765	amino acid transport
M1S24_RS08435	COG0765	amino acid transport
M1S24_RS08440	COG1126	abc transporter atp-binding protein
M1S24_RS08455	COG1522	sequence-specific DNA binding
M1S24_RS08470	COG1309	transcriptional regulator
M1S24_RS08490	COG0583	DNA-binding transcription factor activity
M1S24_RS08500	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S24_RS08510	COG0697	spore germination
M1S24_RS08535	COG3121	Chaperone
M1S24_RS08540	COG3539	Fimbrial protein
M1S24_RS08565	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M1S24_RS08565	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M1S24_RS08610	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M1S24_RS08620	COG2353	YceI-like domain
M1S24_RS08630	COG3698	Phosphodiester glycosidase
M1S24_RS08645	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M1S24_RS08650	COG0506	proline dehydrogenase activity
M1S24_RS08650	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S24_RS08650	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S24_RS08660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S24_RS08665	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M1S24_RS08685	COG1132	(ABC) transporter
M1S24_RS08690	COG3122	Protein conserved in bacteria
M1S24_RS08695	COG3619	membrane
M1S24_RS08705	COG0640	Transcriptional regulator
M1S24_RS08715	COG2850	peptidyl-arginine hydroxylation
M1S24_RS08720	COG0424	maF-like protein
M1S24_RS08740	COG0191	fructose-bisphosphate aldolase activity
M1S24_RS08745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S24_RS08760	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M1S24_RS08770	COG1192	Involved in chromosome partitioning
M1S24_RS08775	COG1475	DNA binding
M1S24_RS08780	COG0811	peptide transport
M1S24_RS08790	COG1132	(ABC) transporter
M1S24_RS08795	COG1663	tetraacyldisaccharide 4'-kinase activity
M1S24_RS08815	COG0084	hydrolase, TatD family'
M1S24_RS08880	COG0776	regulation of translation
M1S24_RS08910	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M1S24_RS08915	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M1S24_RS08965	COG0339	signal peptide processing
M1S24_RS08975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1S24_RS09010	COG0702	epimerase
M1S24_RS09015	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S24_RS09045	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S24_RS09075	COG0316	Belongs to the HesB IscA family
M1S24_RS09080	COG0822	iron-sulfur transferase activity
M1S24_RS09105	COG0776	regulation of translation
M1S24_RS09110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S24_RS09115	COG2207	Transcriptional regulator
M1S24_RS09120	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S24_RS09125	COG1960	acyl-CoA dehydrogenase activity
M1S24_RS09130	COG1960	acyl-CoA dehydrogenase activity
M1S24_RS09145	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M1S24_RS09165	COG4264	IucA IucC family
M1S24_RS09170	COG4264	IucA IucC family
M1S24_RS09210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S24_RS09225	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M1S24_RS09245	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M1S24_RS09250	COG0730	response to heat
M1S24_RS09270	COG4773	Receptor
M1S24_RS09275	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S24_RS09290	COG1131	(ABC) transporter
M1S24_RS09295	COG0842	Transport permease protein
M1S24_RS09300	COG0842	Transport permease protein
M1S24_RS09355	COG2226	methyltransferase
M1S24_RS09380	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M1S24_RS09415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S24_RS09425	COG0133	tryptophan synthase activity
M1S24_RS09440	COG3706	GGDEF domain
M1S24_RS09455	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S24_RS09460	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1S24_RS09465	COG0022	dehydrogenase e1 component
M1S24_RS09470	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S24_RS09475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S24_RS09485	COG1063	alcohol dehydrogenase
M1S24_RS09490	COG3781	membrane
M1S24_RS09500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S24_RS09500	COG3453	Protein conserved in bacteria
M1S24_RS09515	COG0730	response to heat
M1S24_RS09530	COG2207	Transcriptional regulator
M1S24_RS09530	COG3708	Transcriptional regulator
M1S24_RS09535	COG1733	regulation of RNA biosynthetic process
M1S24_RS09540	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M1S24_RS09550	COG2188	Transcriptional regulator
M1S24_RS09565	COG4521	taurine ABC transporter
M1S24_RS09570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S24_RS09590	COG0477	Major facilitator Superfamily
M1S24_RS09600	COG1027	Aspartate ammonia-lyase
M1S24_RS09620	COG0583	DNA-binding transcription factor activity
M1S24_RS09625	COG0183	Belongs to the thiolase family
M1S24_RS09630	COG2031	fatty acid transporter
M1S24_RS09635	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S24_RS09645	COG0583	DNA-binding transcription factor activity
M1S24_RS09655	COG2610	gluconate transmembrane transporter activity
M1S24_RS09660	COG1028	Short-chain dehydrogenase reductase Sdr
M1S24_RS09670	COG2207	Transcriptional regulator
M1S24_RS09685	COG1028	Short-chain dehydrogenase reductase Sdr
M1S24_RS09710	COG0543	2 iron, 2 sulfur cluster binding
M1S24_RS09710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S24_RS09715	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S24_RS09720	COG4638	Rieske (2fe-2S)
M1S24_RS09730	COG0725	ABC transporter, periplasmic molybdate-binding protein
M1S24_RS09735	COG4149	molybdate abc transporter
M1S24_RS09740	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M1S24_RS09745	COG1028	Short-chain dehydrogenase reductase Sdr
M1S24_RS09750	COG3433	isochorismatase activity
M1S24_RS09750	COG1535	isochorismatase
M1S24_RS09810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S24_RS09825	COG0753	catalase activity
M1S24_RS09835	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M1S24_RS09865	COG3539	Fimbrial protein
M1S24_RS09885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S24_RS09905	COG2072	flavoprotein involved in K transport
M1S24_RS09915	COG1538	Outer membrane efflux protein
M1S24_RS09920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S24_RS09925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S24_RS09930	COG0745	RESPONSE REGULATOR receiver
M1S24_RS09935	COG2205	protein histidine kinase activity
M1S24_RS09950	COG2207	Transcriptional regulator
M1S24_RS09965	COG1028	Short-chain dehydrogenase reductase Sdr
M1S24_RS10015	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M1S24_RS10135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S24_RS10155	COG1120	ATPase activity
M1S24_RS10160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S24_RS10170	COG1064	alcohol dehydrogenase
M1S24_RS10185	COG2207	Transcriptional regulator
M1S24_RS10190	COG2084	Dehydrogenase
M1S24_RS10200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1S24_RS10205	COG0583	DNA-binding transcription factor activity
M1S24_RS10215	COG0129	dihydroxy-acid dehydratase activity
M1S24_RS10220	COG1012	belongs to the aldehyde dehydrogenase family
M1S24_RS10235	COG1566	PFAM secretion protein HlyD family protein
M1S24_RS10270	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S24_RS10300	COG0583	DNA-binding transcription factor activity
M1S24_RS10345	COG3210	domain, Protein
M1S24_RS10350	COG2831	hemolysin activation secretion protein
M1S24_RS10360	COG1473	amidohydrolase
M1S24_RS10370	COG0475	glutathione-regulated potassium exporter activity
M1S24_RS10370	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S24_RS10380	COG0583	DNA-binding transcription factor activity
M1S24_RS10385	COG1335	isochorismatase
M1S24_RS10395	COG1309	transcriptional regulator
M1S24_RS10425	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M1S24_RS10435	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S24_RS10435	COG1902	pentaerythritol trinitrate reductase activity
M1S24_RS10440	COG1846	Transcriptional regulator
M1S24_RS10460	COG0753	catalase activity
M1S24_RS10475	COG1012	belongs to the aldehyde dehydrogenase family
M1S24_RS10490	COG3162	membrane
M1S24_RS10500	COG3829	transcription factor binding
M1S24_RS10505	COG1028	Short-chain dehydrogenase reductase Sdr
M1S24_RS10510	COG1960	acyl-CoA dehydrogenase activity
M1S24_RS10550	COG2186	Transcriptional regulator
M1S24_RS10560	COG0583	DNA-binding transcription factor activity
M1S24_RS10565	COG4948	Mandelate Racemase Muconate Lactonizing
M1S24_RS10570	COG4829	muconolactone delta-isomerase
M1S24_RS10580	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S24_RS10585	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S24_RS10590	COG0183	Belongs to the thiolase family
M1S24_RS10595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S24_RS10605	COG1012	belongs to the aldehyde dehydrogenase family
M1S24_RS10615	COG3733	amine oxidase
M1S24_RS10625	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S24_RS10635	COG1028	Short-chain dehydrogenase reductase Sdr
M1S24_RS10645	COG4638	Rieske (2fe-2S)
M1S24_RS10665	COG0154	amidase activity
M1S24_RS10675	COG2814	Major facilitator Superfamily
M1S24_RS10700	COG1960	acyl-CoA dehydrogenase activity
M1S24_RS10705	COG0583	DNA-binding transcription factor activity
M1S24_RS10710	COG1414	Transcriptional regulator
M1S24_RS10725	COG2391	methyltransferase activity
M1S24_RS10735	COG4993	Dehydrogenase
M1S24_RS10740	COG3659	wide pore channel activity
M1S24_RS10745	COG3420	alginic acid biosynthetic process
M1S24_RS10750	COG0710	3-dehydroquinate dehydratase activity
M1S24_RS10755	COG3485	protocatechuate 3,4-dioxygenase
M1S24_RS10760	COG3485	protocatechuate 3,4-dioxygenase
M1S24_RS10765	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S24_RS10770	COG2271	Major facilitator Superfamily
M1S24_RS10775	COG0596	Alpha beta hydrolase
M1S24_RS10780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M1S24_RS10785	COG0183	Belongs to the thiolase family
M1S24_RS10790	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S24_RS10805	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M1S24_RS10810	COG2323	membrane
M1S24_RS10855	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S24_RS10855	COG1902	pentaerythritol trinitrate reductase activity
M1S24_RS10880	COG0542	response to heat
M1S24_RS10885	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M1S24_RS10915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S24_RS10920	COG0569	domain protein
M1S24_RS10925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1S24_RS10940	COG4774	siderophore transport
M1S24_RS10945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1S24_RS10955	COG1585	Membrane protein implicated in regulation of membrane protease activity
M1S24_RS10970	COG1294	oxidase, subunit
M1S24_RS10975	COG4890	Cyd operon protein YbgT
M1S24_RS10990	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M1S24_RS11000	COG0552	protein localization to endoplasmic reticulum
M1S24_RS11025	COG0516	GMP reductase activity
M1S24_RS11025	COG0517	IMP dehydrogenase activity
M1S24_RS11030	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S24_RS11035	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M1S24_RS11045	COG0583	DNA-binding transcription factor activity
M1S24_RS11050	COG0024	Methionine aminopeptidase
M1S24_RS11080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1S24_RS11080	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S24_RS11085	COG1105	Belongs to the carbohydrate kinase PfkB family
M1S24_RS11115	COG5001	Diguanylate cyclase
M1S24_RS11115	COG3300	MHYT domain
M1S24_RS11130	COG2135	peptidase activity
M1S24_RS11135	COG0659	secondary active sulfate transmembrane transporter activity
M1S24_RS11155	COG1113	amino acid transport
M1S24_RS11165	COG1522	sequence-specific DNA binding
M1S24_RS11190	COG1011	Hydrolase
M1S24_RS11195	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M1S24_RS11205	COG2137	regulation of response to DNA damage stimulus
M1S24_RS11220	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S24_RS11255	COG0575	Belongs to the CDS family
M1S24_RS11260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1S24_RS11280	COG3852	Histidine kinase
M1S24_RS11285	COG2204	response regulator
M1S24_RS11350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S24_RS11355	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M1S24_RS11375	COG0697	spore germination
M1S24_RS11380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S24_RS11390	COG0303	'Molybdopterin
M1S24_RS11395	COG0315	cyclic pyranopterin monophosphate synthase activity
M1S24_RS11395	COG0521	Mo-molybdopterin cofactor biosynthetic process
M1S24_RS11410	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1S24_RS11415	COG0243	molybdopterin cofactor binding
M1S24_RS11425	COG0243	molybdopterin cofactor binding
M1S24_RS11430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S24_RS11435	COG2146	nitrite reductase [NAD(P)H] activity
M1S24_RS11435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S24_RS11445	COG0745	RESPONSE REGULATOR receiver
M1S24_RS11450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S24_RS11450	COG1116	anion transmembrane transporter activity
M1S24_RS11470	COG0511	ligase activity, forming carbon-carbon bonds
M1S24_RS11485	COG2814	Major facilitator Superfamily
M1S24_RS11550	COG0739	heme binding
M1S24_RS11670	COG5410	chromosome segregation
M1S24_RS11840	COG0069	glutamate synthase activity
M1S24_RS11860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M1S24_RS11870	COG1454	alcohol dehydrogenase
M1S24_RS11875	COG0824	Thioesterase
M1S24_RS11885	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M1S24_RS11900	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S24_RS11905	COG2030	dehydratase
M1S24_RS11915	COG0183	Belongs to the thiolase family
M1S24_RS11925	COG0583	DNA-binding transcription factor activity
M1S24_RS11930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M1S24_RS11940	COG1522	sequence-specific DNA binding
M1S24_RS11945	COG3135	benzoate transporter
M1S24_RS11955	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M1S24_RS11980	COG0589	response to stress
M1S24_RS11985	COG0488	(ABC) transporter
M1S24_RS12005	COG4773	Receptor
M1S24_RS12040	COG0668	transmembrane transport
M1S24_RS12050	COG1309	transcriptional regulator
M1S24_RS12070	COG1605	Chorismate mutase
M1S24_RS12080	COG4221	oxidoreductase activity
M1S24_RS12090	COG0308	aminopeptidase N
M1S24_RS12110	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M1S24_RS12120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S24_RS12125	COG1454	alcohol dehydrogenase
M1S24_RS12145	COG0531	amino acid
M1S24_RS12150	COG4303	Ethanolamine ammonia lyase large subunit
M1S24_RS12155	COG4302	ethanolamine ammonia-lyase activity
M1S24_RS12160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S24_RS12160	COG0519	Catalyzes the synthesis of GMP from XMP
M1S24_RS12165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S24_RS12175	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S24_RS12190	COG0697	spore germination
M1S24_RS12195	COG1923	regulation of RNA biosynthetic process
M1S24_RS12205	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M1S24_RS12210	COG0802	atpase or kinase
M1S24_RS12230	COG1187	pseudouridine synthase activity
M1S24_RS12250	COG0583	DNA-binding transcription factor activity
M1S24_RS12265	COG2814	Major facilitator Superfamily
M1S24_RS12270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S24_RS12295	COG0729	surface antigen
M1S24_RS12315	COG0174	glutamine synthetase
M1S24_RS12320	COG0745	RESPONSE REGULATOR receiver
M1S24_RS12325	COG2205	protein histidine kinase activity
M1S24_RS12335	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M1S24_RS12365	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S24_RS12370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S24_RS12375	COG1960	acyl-CoA dehydrogenase activity
M1S24_RS12390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S24_RS12395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S24_RS12415	COG0583	DNA-binding transcription factor activity
M1S24_RS12430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S24_RS12440	COG3658	cytochrome
M1S24_RS12445	COG1215	transferase activity, transferring glycosyl groups
M1S24_RS12450	COG0726	polysaccharide deacetylase
M1S24_RS12450	COG1649	PFAM Uncharacterised BCR, COG1649
M1S24_RS12475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M1S24_RS12480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M1S24_RS12490	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M1S24_RS12515	COG0305	Participates in initiation and elongation during chromosome replication
M1S24_RS12520	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M1S24_RS12530	COG1305	Transglutaminase-like
M1S24_RS12540	COG2308	Evidence 4 Homologs of previously reported genes of
M1S24_RS12570	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M1S24_RS12575	COG0138	bifunctional purine biosynthesis protein purh
M1S24_RS12580	COG0151	Belongs to the GarS family
M1S24_RS12585	COG1464	Belongs to the NlpA lipoprotein family
M1S24_RS12590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S24_RS12595	COG2011	ABC-type metal ion transport system permease component
M1S24_RS12600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S24_RS12610	COG1301	dicarboxylic acid transport
M1S24_RS12735	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M1S24_RS12785	COG1012	belongs to the aldehyde dehydrogenase family
M1S24_RS12805	COG0531	amino acid
M1S24_RS12815	COG1113	amino acid transport
M1S24_RS12855	COG3209	COG3209 Rhs family protein
M1S24_RS12885	COG4269	membrane
M1S24_RS12900	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S24_RS12900	COG1902	pentaerythritol trinitrate reductase activity
M1S24_RS12910	COG3706	GGDEF domain
M1S24_RS12910	COG4251	negative regulation of phosphorylation
M1S24_RS12910	COG2203	Gaf domain
M1S24_RS12910	COG5001	Diguanylate cyclase
M1S24_RS12920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S24_RS12940	COG4172	Belongs to the ABC transporter superfamily
M1S24_RS12945	COG4239	(ABC) transporter, permease
M1S24_RS12950	COG4174	ABC transporter (Permease)
M1S24_RS12960	COG0741	lytic transglycosylase activity
M1S24_RS12960	COG1388	LysM domain
M1S24_RS12960	COG0741	lytic transglycosylase activity
M1S24_RS12960	COG1388	LysM domain
M1S24_RS12965	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S24_RS13005	COG0583	DNA-binding transcription factor activity
M1S24_RS13010	COG1279	arginine transmembrane transporter activity
M1S24_RS13030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S24_RS13035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S24_RS13040	COG0006	proline dipeptidase activity
M1S24_RS13125	COG1196	nuclear chromosome segregation
M1S24_RS13125	COG0741	lytic transglycosylase activity
M1S24_RS13125	COG0739	heme binding
M1S24_RS13185	COG4695	Portal protein
M1S24_RS13285	COG0305	Participates in initiation and elongation during chromosome replication
M1S24_RS13300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S24_RS13730	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M1S24_RS13755	COG3384	dioxygenase
M1S24_RS13770	COG2878	Part of a membrane complex involved in electron transport
M1S24_RS13775	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M1S24_RS13800	COG0768	penicillin binding
M1S24_RS13805	COG0742	ribosomal rna small subunit methyltransferase
M1S24_RS13820	COG0830	nickel cation binding
M1S24_RS13830	COG0804	urea catabolic process
M1S24_RS13870	COG1253	flavin adenine dinucleotide binding
M1S24_RS13875	COG2851	Citrate transporter
M1S24_RS13925	COG1773	rubredoxin
M1S24_RS13930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S24_RS13940	COG0583	DNA-binding transcription factor activity
M1S24_RS13965	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M1S24_RS13970	COG4181	ATPase activity
M1S24_RS14015	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M1S24_RS14035	COG0306	phosphate transporter
M1S24_RS14045	COG3958	Transketolase
M1S24_RS14050	COG3959	Transketolase, thiamine diphosphate binding domain
M1S24_RS14055	COG2271	Major facilitator Superfamily
M1S24_RS14060	COG1028	Short-chain dehydrogenase reductase Sdr
M1S24_RS14065	COG0583	DNA-binding transcription factor activity
M1S24_RS14080	COG2223	nitrite transmembrane transporter activity
M1S24_RS14085	COG2207	Transcriptional regulator
M1S24_RS14090	COG2066	Belongs to the glutaminase family
M1S24_RS14095	COG0242	peptide deformylase activity
M1S24_RS14100	COG0477	Major facilitator Superfamily
M1S24_RS14110	COG0028	Belongs to the TPP enzyme family
M1S24_RS14125	COG1028	Short-chain dehydrogenase reductase Sdr
M1S24_RS14130	COG2267	carboxylic ester hydrolase activity
M1S24_RS14140	COG2271	Major facilitator Superfamily
M1S24_RS14145	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S24_RS14155	COG1028	Short-chain dehydrogenase reductase Sdr
M1S24_RS14175	COG1414	Transcriptional regulator
M1S24_RS14190	COG1024	Enoyl-CoA hydratase
M1S24_RS14200	COG1215	transferase activity, transferring glycosyl groups
M1S24_RS14205	COG0726	polysaccharide deacetylase
M1S24_RS14205	COG1649	PFAM Uncharacterised BCR, COG1649
M1S24_RS14215	COG4681	YaeQ
M1S24_RS14225	COG0523	cobalamin synthesis protein
M1S24_RS14235	COG1607	acyl-coa hydrolase
M1S24_RS14245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S24_RS14250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S24_RS14255	COG1309	transcriptional regulator
M1S24_RS14280	COG2040	homocysteine
M1S24_RS14285	COG0531	amino acid
M1S24_RS14340	COG1595	DNA-templated transcription, initiation
M1S24_RS14350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S24_RS14355	COG0477	Major facilitator Superfamily
M1S24_RS14375	COG0084	hydrolase, TatD family'
M1S24_RS14410	COG0629	single-stranded DNA binding
M1S24_RS14465	COG0582	viral genome integration into host DNA
M1S24_RS14495	COG1061	Type III restriction enzyme res subunit
M1S24_RS14505	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S24_RS14510	COG1192	Involved in chromosome partitioning
M1S24_RS14520	COG1061	Type III restriction enzyme res subunit
M1S24_RS14610	COG0592	DNA-directed DNA polymerase activity
M1S24_RS14650	COG2026	Addiction module toxin, RelE StbE family
M1S24_RS14800	COG3755	Protein conserved in bacteria
M1S24_RS14845	COG1484	DNA-dependent DNA replication
M1S24_RS14935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S24_RS15005	COG0405	Gamma-glutamyltransferase
M1S24_RS15010	COG2814	Major facilitator Superfamily
M1S24_RS15020	COG2050	protein possibly involved in aromatic compounds catabolism
M1S24_RS15035	COG1090	epimerase
M1S24_RS15055	COG0420	3'-5' exonuclease activity
M1S24_RS15080	COG0735	belongs to the Fur family
M1S24_RS15085	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M1S24_RS15105	COG0121	glutamine amidotransferase
M1S24_RS15120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S24_RS15130	COG0210	DNA helicase
M1S24_RS15135	COG2885	chlorophyll binding
M1S24_RS15140	COG0204	Acyl-transferase
M1S24_RS15155	COG2894	cell division
M1S24_RS15180	COG1280	lysine exporter protein (LysE YggA)
M1S24_RS15185	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M1S24_RS15185	COG1674	ftsk spoiiie
M1S24_RS15190	COG0492	ferredoxin-NADP+ reductase activity
M1S24_RS15195	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M1S24_RS15205	COG0456	acetyltransferase
M1S24_RS15250	COG1981	membrane
M1S24_RS15265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S24_RS15265	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M1S24_RS15285	COG1012	belongs to the aldehyde dehydrogenase family
M1S24_RS15295	COG0657	acetylesterase activity
M1S24_RS15305	COG0473	3-isopropylmalate dehydrogenase activity
M1S24_RS15310	COG0583	DNA-binding transcription factor activity
M1S24_RS15330	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S24_RS15355	COG0564	pseudouridine synthase activity
M1S24_RS15365	COG0358	DNA primase activity
M1S24_RS15380	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M1S24_RS15410	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S24_RS15440	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M1S24_RS15450	COG0351	phosphomethylpyrimidine kinase
M1S24_RS15450	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S24_RS15450	COG0352	thiamine-phosphate diphosphorylase activity
M1S24_RS15455	COG1652	LysM domain
M1S24_RS15480	COG1399	metal-binding, possibly nucleic acid-binding protein
M1S24_RS15485	COG3101	peptidyl-lysine hydroxylation
M1S24_RS15490	COG0009	L-threonylcarbamoyladenylate synthase
M1S24_RS15495	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M1S24_RS15500	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M1S24_RS15515	COG4106	trans-aconitate 2-methyltransferase activity
M1S24_RS15530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S24_RS15530	COG2226	methyltransferase
M1S24_RS15530	COG0596	Alpha beta hydrolase
M1S24_RS15535	COG1877	trehalose-phosphatase activity
M1S24_RS15540	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
M1S24_RS15545	COG2223	nitrite transmembrane transporter activity
M1S24_RS15565	COG1196	nuclear chromosome segregation
M1S24_RS15575	COG0730	response to heat
M1S24_RS15590	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M1S24_RS15600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S24_RS15660	COG0489	protein tyrosine kinase activity
M1S24_RS15670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S24_RS15670	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S24_RS15700	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M1S24_RS15705	COG2081	HI0933 family
M1S24_RS15715	COG0668	transmembrane transport
M1S24_RS15735	COG0583	DNA-binding transcription factor activity
M1S24_RS15755	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1S24_RS15760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S24_RS15790	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M1S24_RS15830	COG0745	RESPONSE REGULATOR receiver
M1S24_RS15850	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S24_RS15860	COG2205	protein histidine kinase activity
M1S24_RS15930	COG4993	Dehydrogenase
M1S24_RS15955	COG0384	phenazine biosynthesis protein PhzF
M1S24_RS15980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S24_RS15995	COG0583	DNA-binding transcription factor activity
M1S24_RS16025	COG0583	DNA-binding transcription factor activity
M1S24_RS16040	COG0583	DNA-binding transcription factor activity
M1S24_RS16045	COG1053	succinate dehydrogenase
M1S24_RS16055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M1S24_RS16060	COG2814	Major facilitator Superfamily
M1S24_RS16065	COG1960	acyl-CoA dehydrogenase activity
M1S24_RS16070	COG0583	DNA-binding transcription factor activity
M1S24_RS16075	COG1063	alcohol dehydrogenase
M1S24_RS16105	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M1S24_RS16110	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M1S24_RS16115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S24_RS16130	COG3667	copper resistance
M1S24_RS16135	COG2132	Multicopper oxidase
M1S24_RS16145	COG0561	phosphatase activity
M1S24_RS16150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M1S24_RS16175	COG1214	PFAM Peptidase M22, glycoprotease
M1S24_RS16225	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M1S24_RS16235	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M1S24_RS16240	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M1S24_RS16245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M1S24_RS16305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S24_RS16315	COG1846	Transcriptional regulator
M1S24_RS16320	COG1764	response to oxidative stress
M1S24_RS16360	COG0037	tRNA processing
M1S24_RS16370	COG0248	Ppx GppA phosphatase
M1S24_RS16400	COG0072	phenylalanine-tRNA ligase activity
M1S24_RS16445	COG1238	metal cluster binding
M1S24_RS16450	COG0625	glutathione transferase activity
M1S24_RS16465	COG0318	PFAM AMP-dependent synthetase and ligase
M1S24_RS16470	COG3028	Belongs to the UPF0307 family
M1S24_RS16475	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S24_RS16495	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M1S24_RS16500	COG0617	tRNA 3'-terminal CCA addition
M1S24_RS16505	COG1555	photosystem II stabilization
M1S24_RS16510	COG3956	TIGRFAM MazG family protein
M1S24_RS16520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S24_RS16540	COG5002	protein histidine kinase activity
M1S24_RS16540	COG2205	protein histidine kinase activity
M1S24_RS16540	COG0784	Response regulator, receiver
M1S24_RS16545	COG1024	Enoyl-CoA hydratase
M1S24_RS16550	COG2084	Dehydrogenase
M1S24_RS16555	COG3622	Belongs to the hyi family
M1S24_RS16585	COG0697	spore germination
M1S24_RS16595	COG2814	Major facilitator Superfamily
M1S24_RS16600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S24_RS16610	COG0583	DNA-binding transcription factor activity
M1S24_RS16620	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M1S24_RS16635	COG0084	hydrolase, TatD family'
M1S24_RS16650	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M1S24_RS16680	COG0440	acetolactate synthase activity
M1S24_RS16685	COG0028	Belongs to the TPP enzyme family
M1S24_RS16710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S24_RS16715	COG1136	(ABC) transporter
M1S24_RS16715	COG0577	efflux transmembrane transporter activity
M1S24_RS16720	COG1538	Outer membrane efflux protein
M1S24_RS16735	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M1S24_RS16740	COG1162	GTPase activity
M1S24_RS16750	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M1S24_RS16770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M1S24_RS16775	COG1028	Short-chain dehydrogenase reductase Sdr
M1S24_RS16815	COG2986	histidine ammonia-lyase
M1S24_RS16830	COG0318	PFAM AMP-dependent synthetase and ligase
M1S24_RS16840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S24_RS16885	COG1426	Protein conserved in bacteria
M1S24_RS16920	COG0793	Belongs to the peptidase S41A family
M1S24_RS16935	COG2267	carboxylic ester hydrolase activity
M1S24_RS16945	COG1012	belongs to the aldehyde dehydrogenase family
M1S24_RS16950	COG3265	gluconokinase activity
M1S24_RS16960	COG0800	Aldolase
M1S24_RS16970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M1S24_RS16975	COG0857	belongs to the CobB CobQ family
M1S24_RS16975	COG0280	phosphate acetyltransferase
M1S24_RS16980	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S24_RS16980	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S24_RS17000	COG0740	serine-type endopeptidase activity
M1S24_RS17010	COG4774	siderophore transport
M1S24_RS17020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1S24_RS17030	COG2813	Specifically methylates the guanine in position
M1S24_RS17030	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S24_RS17130	COG0788	formyltetrahydrofolate deformylase activity
M1S24_RS17155	COG4651	solute:proton antiporter activity
M1S24_RS17155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S24_RS17175	COG0724	RNA recognition motif
M1S24_RS17180	COG0210	DNA helicase
M1S24_RS17205	COG1733	regulation of RNA biosynthetic process
M1S24_RS17215	COG2900	Belongs to the SlyX family
M1S24_RS17220	COG0488	(ABC) transporter
M1S24_RS17225	COG1280	lysine exporter protein (LysE YggA)
M1S24_RS17230	COG1560	Kdo2-lipid A biosynthetic process
M1S24_RS17240	COG1301	dicarboxylic acid transport
M1S24_RS17295	COG0473	3-isopropylmalate dehydrogenase activity
M1S24_RS17360	COG0583	DNA-binding transcription factor activity
M1S24_RS17370	COG0625	glutathione transferase activity
M1S24_RS17375	COG2378	regulation of single-species biofilm formation
M1S24_RS17380	COG0546	phosphoglycolate phosphatase activity
M1S24_RS17390	COG1530	ribonuclease E activity
M1S24_RS17395	COG0318	PFAM AMP-dependent synthetase and ligase
M1S24_RS17410	COG0583	DNA-binding transcription factor activity
M1S24_RS17415	COG4221	oxidoreductase activity
M1S24_RS17420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M1S24_RS17430	COG0534	Mate efflux family protein
M1S24_RS17445	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M1S24_RS17485	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M1S24_RS17490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S24_RS17505	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S24_RS17515	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
M1S24_RS17515	COG0644	oxidoreductase
M1S24_RS17520	COG0425	Belongs to the sulfur carrier protein TusA family
M1S24_RS17525	COG4535	Mg2 and Co2 transporter CorC
M1S24_RS17535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S24_RS17555	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M1S24_RS17560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S24_RS17560	COG0475	glutathione-regulated potassium exporter activity
M1S24_RS17565	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M1S24_RS17575	COG0484	heat shock protein binding
M1S24_RS17580	COG0789	Transcriptional regulator
M1S24_RS17585	COG0598	Magnesium transport protein CorA
M1S24_RS17600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S24_RS17605	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S24_RS17610	COG1074	ATP-dependent DNA helicase activity
M1S24_RS17615	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M1S24_RS17635	COG2226	methyltransferase
M1S24_RS17650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S24_RS17655	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M1S24_RS17670	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S24_RS17670	COG2111	Na H antiporter
M1S24_RS17675	COG1006	Multisubunit Na H antiporter MnhC subunit
M1S24_RS17680	COG0651	ATP synthesis coupled electron transport
M1S24_RS17685	COG1863	multisubunit Na H antiporter MnhE subunit
M1S24_RS17690	COG2212	antiporter activity
M1S24_RS17695	COG1320	monovalent cation:proton antiporter activity
M1S24_RS17710	COG0195	Participates in both transcription termination and antitermination
M1S24_RS17760	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M1S24_RS17765	COG0237	dephospho-CoA kinase activity
M1S24_RS17775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S24_RS17790	COG0497	DNA recombination
M1S24_RS17800	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M1S24_RS17830	COG2169	Transcriptional regulator
M1S24_RS17830	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S24_RS17835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M1S24_RS17900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M1S24_RS17915	COG0326	Molecular chaperone. Has ATPase activity
M1S24_RS17930	COG2056	Na+-H+ antiporter family
M1S24_RS17935	COG0596	Alpha beta hydrolase
M1S24_RS18030	COG0546	phosphoglycolate phosphatase activity
M1S24_RS18035	COG1716	ATPase activity
M1S24_RS18080	COG0181	hydroxymethylbilane synthase activity
M1S24_RS18090	COG3275	phosphorelay sensor kinase activity
M1S24_RS18110	COG1538	Outer membrane efflux protein
M1S24_RS18115	COG0697	spore germination
M1S24_RS18140	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S24_RS18145	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M1S24_RS18150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S24_RS18155	COG0772	Belongs to the SEDS family
M1S24_RS18180	COG4974	Belongs to the 'phage' integrase family
M1S24_RS18185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S24_RS18195	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M1S24_RS18205	COG2197	response regulator
M1S24_RS18220	COG0793	Belongs to the peptidase S41A family
M1S24_RS18225	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M1S24_RS18230	COG0795	lipopolysaccharide-transporting ATPase activity
M1S24_RS18270	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S24_RS18270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S24_RS18280	COG0004	ammonium transporteR
M1S24_RS18285	COG0347	Belongs to the P(II) protein family
M1S24_RS18345	COG0659	secondary active sulfate transmembrane transporter activity
M1S24_RS18350	COG0589	response to stress
M1S24_RS18385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S24_RS18395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S24_RS18415	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M1S24_RS18430	COG0318	PFAM AMP-dependent synthetase and ligase
M1S24_RS18440	COG0477	Major facilitator Superfamily
M1S24_RS18445	COG2860	membrane
M1S24_RS18455	COG1253	flavin adenine dinucleotide binding
M1S24_RS18475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1S24_RS18515	COG0655	NAD(P)H dehydrogenase (quinone) activity
M1S24_RS18525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M1S24_RS18595	COG0758	DNA mediated transformation
M1S24_RS18605	COG0697	spore germination
M1S24_RS18610	COG1309	transcriptional regulator
M1S24_RS18625	COG0386	Belongs to the glutathione peroxidase family
M1S24_RS18690	COG1121	(ABC) transporter
M1S24_RS18695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1S24_RS18700	COG1280	lysine exporter protein (LysE YggA)
M1S24_RS18705	COG2837	iron assimilation
M1S24_RS18715	COG0281	malic enzyme
M1S24_RS18760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S24_RS18760	COG0519	Catalyzes the synthesis of GMP from XMP
M1S24_RS18770	COG2259	Doxx family
M1S24_RS18775	COG0586	Pfam SNARE associated Golgi protein
M1S24_RS18790	COG1192	Involved in chromosome partitioning
M1S24_RS18800	COG0271	Belongs to the BolA IbaG family
M1S24_RS18820	COG2267	carboxylic ester hydrolase activity
M1S24_RS18840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S24_RS18840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M1S24_RS18840	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M1S24_RS18840	COG3321	synthase
M1S24_RS18845	COG1960	acyl-CoA dehydrogenase activity
M1S24_RS18855	COG2197	response regulator
M1S24_RS18865	COG3916	Acyl-homoserine-lactone synthase
M1S24_RS18870	COG0477	Major facilitator Superfamily
M1S24_RS18875	COG1024	Enoyl-CoA hydratase
M1S24_RS18880	COG1024	Enoyl-CoA hydratase
M1S24_RS18885	COG1960	acyl-CoA dehydrogenase activity
M1S24_RS18890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S24_RS18910	COG1113	amino acid transport
M1S24_RS18915	COG1113	amino acid transport
M1S24_RS18920	COG0251	oxidation-reduction process
M1S24_RS18960	COG0564	pseudouridine synthase activity
M1S24_RS19020	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M1S24_RS19040	COG1448	Aminotransferase
M1S24_RS19045	COG0277	FAD linked oxidase domain protein
M1S24_RS19055	COG2186	Transcriptional regulator
M1S24_RS19065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S24_RS19070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S24_RS19085	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M1S24_RS19095	COG1216	Glycosyl transferase, family 2
M1S24_RS19115	COG3562	capsule polysaccharide
M1S24_RS19130	COG2089	acid synthase
M1S24_RS19145	COG1083	cytidylyl-transferase
M1S24_RS19150	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M1S24_RS19155	COG1086	Polysaccharide biosynthesis protein
M1S24_RS19160	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M1S24_RS19165	COG1596	polysaccharide export
M1S24_RS19190	COG0728	peptidoglycan biosynthetic process
M1S24_RS19195	COG3023	N-Acetylmuramoyl-L-alanine amidase
M1S24_RS19255	COG0546	phosphoglycolate phosphatase activity
M1S24_RS19260	COG1028	Short-chain dehydrogenase reductase Sdr
M1S24_RS19280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S24_RS19285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S24_RS19290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S24_RS19295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S24_RS19300	COG1116	anion transmembrane transporter activity
M1S24_RS19305	COG1309	transcriptional regulator
M1S24_RS19310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M1S24_RS19320	COG0196	riboflavin kinase activity
M1S24_RS19325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M1S24_RS19335	COG1047	Peptidyl-prolyl cis-trans
M1S24_RS19375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M1S24_RS19380	COG0657	acetylesterase activity
M1S24_RS19400	COG0583	DNA-binding transcription factor activity
M1S24_RS19430	COG2951	lytic endotransglycosylase activity
M1S24_RS19435	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M1S24_RS19450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M1S24_RS19460	COG0671	phosphoesterase, PA-phosphatase related
M1S24_RS19465	COG0861	Integral membrane protein TerC family
M1S24_RS19475	COG0754	glutathionylspermidine amidase activity
M1S24_RS19485	COG0402	S-adenosylhomocysteine deaminase activity
M1S24_RS19500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S24_RS19505	COG1230	cation diffusion facilitator family transporter
M1S24_RS19520	COG0706	membrane insertase activity
M1S24_RS19560	COG0358	DNA primase activity
M1S24_RS19615	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S24_RS19660	COG0587	DNA-directed DNA polymerase activity
M1S24_RS19675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1S24_RS19675	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1S24_RS19725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S24_RS19725	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M1S24_RS19730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S24_RS19770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S24_RS19815	COG1309	transcriptional regulator
M1S24_RS19825	COG1902	pentaerythritol trinitrate reductase activity
M1S24_RS19835	COG1979	alcohol dehydrogenase
M1S24_RS19850	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
M1S24_RS19875	COG1063	alcohol dehydrogenase
M1S24_RS19950	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S24_RS19975	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system