locus-tag	class	description
L2Z08_RS00035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2Z08_RS00045	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2Z08_RS00085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z08_RS00095	COG2814	Major facilitator Superfamily
L2Z08_RS00105	COG1253	flavin adenine dinucleotide binding
L2Z08_RS00115	COG2860	membrane
L2Z08_RS00120	COG0477	Major facilitator Superfamily
L2Z08_RS00130	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z08_RS00145	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Z08_RS00165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z08_RS00175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z08_RS00220	COG0589	response to stress
L2Z08_RS00225	COG0659	secondary active sulfate transmembrane transporter activity
L2Z08_RS00285	COG0347	Belongs to the P(II) protein family
L2Z08_RS00290	COG0004	ammonium transporteR
L2Z08_RS00300	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z08_RS00300	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z08_RS00340	COG0795	lipopolysaccharide-transporting ATPase activity
L2Z08_RS00345	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Z08_RS00350	COG0793	Belongs to the peptidase S41A family
L2Z08_RS00365	COG2197	response regulator
L2Z08_RS00375	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2Z08_RS00385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z08_RS00390	COG4974	Belongs to the 'phage' integrase family
L2Z08_RS00415	COG0772	Belongs to the SEDS family
L2Z08_RS00420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z08_RS00425	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Z08_RS00430	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z08_RS00455	COG0697	spore germination
L2Z08_RS00460	COG1538	Outer membrane efflux protein
L2Z08_RS00480	COG3275	phosphorelay sensor kinase activity
L2Z08_RS00490	COG0181	hydroxymethylbilane synthase activity
L2Z08_RS00535	COG1716	ATPase activity
L2Z08_RS00540	COG0546	phosphoglycolate phosphatase activity
L2Z08_RS00645	COG0596	Alpha beta hydrolase
L2Z08_RS00650	COG2056	Na+-H+ antiporter family
L2Z08_RS00665	COG0326	Molecular chaperone. Has ATPase activity
L2Z08_RS00680	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2Z08_RS00745	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2Z08_RS00750	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z08_RS00750	COG2169	Transcriptional regulator
L2Z08_RS00780	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Z08_RS00790	COG0497	DNA recombination
L2Z08_RS00805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z08_RS00815	COG0237	dephospho-CoA kinase activity
L2Z08_RS00820	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L2Z08_RS00870	COG0195	Participates in both transcription termination and antitermination
L2Z08_RS00885	COG1320	monovalent cation:proton antiporter activity
L2Z08_RS00890	COG2212	antiporter activity
L2Z08_RS00895	COG1863	multisubunit Na H antiporter MnhE subunit
L2Z08_RS00900	COG0651	ATP synthesis coupled electron transport
L2Z08_RS00905	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Z08_RS00910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z08_RS00910	COG2111	Na H antiporter
L2Z08_RS00925	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Z08_RS00930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z08_RS00945	COG2226	methyltransferase
L2Z08_RS00965	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Z08_RS00970	COG1074	ATP-dependent DNA helicase activity
L2Z08_RS00975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z08_RS00980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z08_RS00995	COG0598	Magnesium transport protein CorA
L2Z08_RS01000	COG0789	Transcriptional regulator
L2Z08_RS01005	COG0484	heat shock protein binding
L2Z08_RS01015	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L2Z08_RS01020	COG0475	glutathione-regulated potassium exporter activity
L2Z08_RS01020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z08_RS01025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Z08_RS01045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z08_RS01055	COG4535	Mg2 and Co2 transporter CorC
L2Z08_RS01060	COG0425	Belongs to the sulfur carrier protein TusA family
L2Z08_RS01065	COG0644	oxidoreductase
L2Z08_RS01065	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2Z08_RS01075	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z08_RS01090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z08_RS01095	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2Z08_RS01135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Z08_RS01150	COG0534	Mate efflux family protein
L2Z08_RS01160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z08_RS01165	COG4221	oxidoreductase activity
L2Z08_RS01170	COG0583	DNA-binding transcription factor activity
L2Z08_RS01185	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z08_RS01190	COG1530	ribonuclease E activity
L2Z08_RS01200	COG0546	phosphoglycolate phosphatase activity
L2Z08_RS01205	COG2378	regulation of single-species biofilm formation
L2Z08_RS01210	COG0625	glutathione transferase activity
L2Z08_RS01220	COG0583	DNA-binding transcription factor activity
L2Z08_RS01285	COG0473	3-isopropylmalate dehydrogenase activity
L2Z08_RS01340	COG1301	dicarboxylic acid transport
L2Z08_RS01350	COG1560	Kdo2-lipid A biosynthetic process
L2Z08_RS01355	COG1280	lysine exporter protein (LysE YggA)
L2Z08_RS01360	COG0488	(ABC) transporter
L2Z08_RS01365	COG2900	Belongs to the SlyX family
L2Z08_RS01375	COG1733	regulation of RNA biosynthetic process
L2Z08_RS01400	COG0210	DNA helicase
L2Z08_RS01405	COG0724	RNA recognition motif
L2Z08_RS01425	COG4651	solute:proton antiporter activity
L2Z08_RS01425	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z08_RS01450	COG0788	formyltetrahydrofolate deformylase activity
L2Z08_RS01550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z08_RS01550	COG2813	Specifically methylates the guanine in position
L2Z08_RS01560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z08_RS01580	COG0740	serine-type endopeptidase activity
L2Z08_RS01600	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z08_RS01600	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z08_RS01605	COG0857	belongs to the CobB CobQ family
L2Z08_RS01605	COG0280	phosphate acetyltransferase
L2Z08_RS01610	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Z08_RS01620	COG0800	Aldolase
L2Z08_RS01630	COG3265	gluconokinase activity
L2Z08_RS01635	COG1012	belongs to the aldehyde dehydrogenase family
L2Z08_RS01645	COG2267	carboxylic ester hydrolase activity
L2Z08_RS01660	COG0793	Belongs to the peptidase S41A family
L2Z08_RS01695	COG1426	Protein conserved in bacteria
L2Z08_RS01740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z08_RS01755	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z08_RS01770	COG2986	histidine ammonia-lyase
L2Z08_RS01810	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z08_RS01815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L2Z08_RS01835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2Z08_RS01845	COG1162	GTPase activity
L2Z08_RS01850	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Z08_RS01865	COG1538	Outer membrane efflux protein
L2Z08_RS01870	COG1136	(ABC) transporter
L2Z08_RS01870	COG0577	efflux transmembrane transporter activity
L2Z08_RS01875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z08_RS01900	COG0028	Belongs to the TPP enzyme family
L2Z08_RS01905	COG0440	acetolactate synthase activity
L2Z08_RS01935	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Z08_RS01950	COG0084	hydrolase, TatD family'
L2Z08_RS01970	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Z08_RS01980	COG0583	DNA-binding transcription factor activity
L2Z08_RS01990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z08_RS01995	COG2814	Major facilitator Superfamily
L2Z08_RS02005	COG0697	spore germination
L2Z08_RS02035	COG3622	Belongs to the hyi family
L2Z08_RS02040	COG2084	Dehydrogenase
L2Z08_RS02045	COG1024	Enoyl-CoA hydratase
L2Z08_RS02050	COG0784	Response regulator, receiver
L2Z08_RS02050	COG2205	protein histidine kinase activity
L2Z08_RS02050	COG5002	protein histidine kinase activity
L2Z08_RS02070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z08_RS02080	COG3956	TIGRFAM MazG family protein
L2Z08_RS02085	COG1555	photosystem II stabilization
L2Z08_RS02090	COG0617	tRNA 3'-terminal CCA addition
L2Z08_RS02095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Z08_RS02115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z08_RS02120	COG3028	Belongs to the UPF0307 family
L2Z08_RS02125	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z08_RS02140	COG0625	glutathione transferase activity
L2Z08_RS02145	COG1238	metal cluster binding
L2Z08_RS02190	COG0072	phenylalanine-tRNA ligase activity
L2Z08_RS02220	COG0248	Ppx GppA phosphatase
L2Z08_RS02230	COG0037	tRNA processing
L2Z08_RS02270	COG1764	response to oxidative stress
L2Z08_RS02275	COG1846	Transcriptional regulator
L2Z08_RS02285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z08_RS02345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2Z08_RS02350	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Z08_RS02355	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Z08_RS02365	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L2Z08_RS02415	COG1214	PFAM Peptidase M22, glycoprotease
L2Z08_RS02440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z08_RS02445	COG0561	phosphatase activity
L2Z08_RS02455	COG2132	Multicopper oxidase
L2Z08_RS02460	COG3667	copper resistance
L2Z08_RS02475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z08_RS02480	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Z08_RS02485	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Z08_RS02515	COG1063	alcohol dehydrogenase
L2Z08_RS02520	COG0583	DNA-binding transcription factor activity
L2Z08_RS02525	COG1960	acyl-CoA dehydrogenase activity
L2Z08_RS02530	COG2814	Major facilitator Superfamily
L2Z08_RS02535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z08_RS02545	COG1053	succinate dehydrogenase
L2Z08_RS02550	COG0583	DNA-binding transcription factor activity
L2Z08_RS02565	COG0583	DNA-binding transcription factor activity
L2Z08_RS02595	COG0583	DNA-binding transcription factor activity
L2Z08_RS02610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z08_RS02635	COG0384	phenazine biosynthesis protein PhzF
L2Z08_RS02655	COG4993	Dehydrogenase
L2Z08_RS02720	COG2205	protein histidine kinase activity
L2Z08_RS02740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Z08_RS02760	COG0745	RESPONSE REGULATOR receiver
L2Z08_RS02800	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Z08_RS02830	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z08_RS02835	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Z08_RS02855	COG0583	DNA-binding transcription factor activity
L2Z08_RS02875	COG0668	transmembrane transport
L2Z08_RS02885	COG2081	HI0933 family
L2Z08_RS02890	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z08_RS02920	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z08_RS02920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z08_RS02930	COG0489	protein tyrosine kinase activity
L2Z08_RS02980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z08_RS02990	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Z08_RS03005	COG0730	response to heat
L2Z08_RS03015	COG1196	nuclear chromosome segregation
L2Z08_RS03035	COG2223	nitrite transmembrane transporter activity
L2Z08_RS03040	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2Z08_RS03050	COG2226	methyltransferase
L2Z08_RS03050	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z08_RS03050	COG0596	Alpha beta hydrolase
L2Z08_RS03065	COG4106	trans-aconitate 2-methyltransferase activity
L2Z08_RS03080	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Z08_RS03085	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2Z08_RS03090	COG0009	L-threonylcarbamoyladenylate synthase
L2Z08_RS03095	COG3101	peptidyl-lysine hydroxylation
L2Z08_RS03100	COG1399	metal-binding, possibly nucleic acid-binding protein
L2Z08_RS03125	COG1652	LysM domain
L2Z08_RS03130	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z08_RS03130	COG0351	phosphomethylpyrimidine kinase
L2Z08_RS03130	COG0352	thiamine-phosphate diphosphorylase activity
L2Z08_RS03140	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2Z08_RS03170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z08_RS03200	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Z08_RS03215	COG0358	DNA primase activity
L2Z08_RS03225	COG0564	pseudouridine synthase activity
L2Z08_RS03250	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z08_RS03270	COG0583	DNA-binding transcription factor activity
L2Z08_RS03275	COG0473	3-isopropylmalate dehydrogenase activity
L2Z08_RS03285	COG0657	acetylesterase activity
L2Z08_RS03295	COG1012	belongs to the aldehyde dehydrogenase family
L2Z08_RS03315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z08_RS03315	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Z08_RS03330	COG1981	membrane
L2Z08_RS03375	COG0456	acetyltransferase
L2Z08_RS03385	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Z08_RS03390	COG0492	ferredoxin-NADP+ reductase activity
L2Z08_RS03395	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Z08_RS03395	COG1674	ftsk spoiiie
L2Z08_RS03400	COG1280	lysine exporter protein (LysE YggA)
L2Z08_RS03425	COG2894	cell division
L2Z08_RS03440	COG0204	Acyl-transferase
L2Z08_RS03445	COG2885	chlorophyll binding
L2Z08_RS03450	COG0210	DNA helicase
L2Z08_RS03460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z08_RS03475	COG0121	glutamine amidotransferase
L2Z08_RS03495	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z08_RS03500	COG0735	belongs to the Fur family
L2Z08_RS03525	COG0420	3'-5' exonuclease activity
L2Z08_RS03545	COG1090	epimerase
L2Z08_RS03560	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z08_RS03570	COG2814	Major facilitator Superfamily
L2Z08_RS03575	COG0405	Gamma-glutamyltransferase
L2Z08_RS03585	COG0582	viral genome integration into host DNA
L2Z08_RS03620	COG2801	Transposase and inactivated derivatives
L2Z08_RS03640	COG0629	single-stranded DNA binding
L2Z08_RS03700	COG0477	Major facilitator Superfamily
L2Z08_RS03705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z08_RS03730	COG0531	amino acid
L2Z08_RS03735	COG2040	homocysteine
L2Z08_RS03760	COG1309	transcriptional regulator
L2Z08_RS03765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z08_RS03770	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z08_RS03780	COG1607	acyl-coa hydrolase
L2Z08_RS03790	COG0523	cobalamin synthesis protein
L2Z08_RS03800	COG4681	YaeQ
L2Z08_RS03810	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z08_RS03810	COG0726	polysaccharide deacetylase
L2Z08_RS03815	COG1215	transferase activity, transferring glycosyl groups
L2Z08_RS03825	COG1024	Enoyl-CoA hydratase
L2Z08_RS03840	COG1414	Transcriptional regulator
L2Z08_RS03860	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z08_RS03870	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z08_RS03875	COG2271	Major facilitator Superfamily
L2Z08_RS03885	COG2267	carboxylic ester hydrolase activity
L2Z08_RS03890	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z08_RS03905	COG0028	Belongs to the TPP enzyme family
L2Z08_RS03915	COG0477	Major facilitator Superfamily
L2Z08_RS03920	COG0242	peptide deformylase activity
L2Z08_RS03925	COG2066	Belongs to the glutaminase family
L2Z08_RS03930	COG2207	Transcriptional regulator
L2Z08_RS03935	COG2223	nitrite transmembrane transporter activity
L2Z08_RS03950	COG0583	DNA-binding transcription factor activity
L2Z08_RS03955	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z08_RS03960	COG2271	Major facilitator Superfamily
L2Z08_RS03965	COG3959	Transketolase, thiamine diphosphate binding domain
L2Z08_RS03970	COG3958	Transketolase
L2Z08_RS03980	COG0306	phosphate transporter
L2Z08_RS04000	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z08_RS04045	COG4181	ATPase activity
L2Z08_RS04050	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Z08_RS04075	COG0583	DNA-binding transcription factor activity
L2Z08_RS04085	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z08_RS04090	COG1773	rubredoxin
L2Z08_RS04140	COG2851	Citrate transporter
L2Z08_RS04145	COG1253	flavin adenine dinucleotide binding
L2Z08_RS04185	COG0804	urea catabolic process
L2Z08_RS04195	COG0830	nickel cation binding
L2Z08_RS04210	COG0742	ribosomal rna small subunit methyltransferase
L2Z08_RS04215	COG0768	penicillin binding
L2Z08_RS04240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Z08_RS04245	COG2878	Part of a membrane complex involved in electron transport
L2Z08_RS04250	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z08_RS04260	COG3384	dioxygenase
L2Z08_RS04290	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2Z08_RS04615	COG0739	heme binding
L2Z08_RS04700	COG0006	proline dipeptidase activity
L2Z08_RS04705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z08_RS04710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z08_RS04730	COG1279	arginine transmembrane transporter activity
L2Z08_RS04735	COG0583	DNA-binding transcription factor activity
L2Z08_RS04775	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z08_RS04780	COG0741	lytic transglycosylase activity
L2Z08_RS04780	COG0741	lytic transglycosylase activity
L2Z08_RS04780	COG1388	LysM domain
L2Z08_RS04780	COG1388	LysM domain
L2Z08_RS04790	COG4174	ABC transporter (Permease)
L2Z08_RS04795	COG4239	(ABC) transporter, permease
L2Z08_RS04800	COG4172	Belongs to the ABC transporter superfamily
L2Z08_RS04820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z08_RS04830	COG4251	negative regulation of phosphorylation
L2Z08_RS04830	COG3706	GGDEF domain
L2Z08_RS04830	COG2203	Gaf domain
L2Z08_RS04830	COG5001	Diguanylate cyclase
L2Z08_RS04840	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z08_RS04840	COG1902	pentaerythritol trinitrate reductase activity
L2Z08_RS04855	COG4269	membrane
L2Z08_RS04885	COG3209	COG3209 Rhs family protein
L2Z08_RS04935	COG1113	amino acid transport
L2Z08_RS04945	COG0531	amino acid
L2Z08_RS04965	COG1012	belongs to the aldehyde dehydrogenase family
L2Z08_RS05095	COG0300	oxidoreductase activity
L2Z08_RS05105	COG1309	transcriptional regulator
L2Z08_RS05110	COG1741	Belongs to the pirin family
L2Z08_RS05125	COG2072	flavoprotein involved in K transport
L2Z08_RS05135	COG2252	PERMEase
L2Z08_RS05140	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2Z08_RS05145	COG3038	cytochrome b561
L2Z08_RS05155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2Z08_RS05165	COG0527	aspartate kinase activity
L2Z08_RS05175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Z08_RS05185	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Z08_RS05200	COG0667	Aldo Keto reductase
L2Z08_RS05220	COG1765	OsmC-like protein
L2Z08_RS05235	COG0542	response to heat
L2Z08_RS05270	COG2885	chlorophyll binding
L2Z08_RS05280	COG0625	glutathione transferase activity
L2Z08_RS05285	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2Z08_RS05305	COG3634	alkyl hydroperoxide reductase activity
L2Z08_RS05315	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2Z08_RS05325	COG0450	alkyl hydroperoxide reductase
L2Z08_RS05330	COG1643	Atp-dependent helicase
L2Z08_RS05345	COG2814	Major facilitator Superfamily
L2Z08_RS05350	COG3135	benzoate transporter
L2Z08_RS05355	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z08_RS05360	COG0543	2 iron, 2 sulfur cluster binding
L2Z08_RS05360	COG0633	Ferredoxin
L2Z08_RS05365	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z08_RS05370	COG4638	Rieske (2fe-2S)
L2Z08_RS05380	COG0583	DNA-binding transcription factor activity
L2Z08_RS05430	COG1570	exodeoxyribonuclease VII activity
L2Z08_RS05465	COG1278	Cold shock
L2Z08_RS05500	COG2814	Major facilitator Superfamily
L2Z08_RS05535	COG0517	IMP dehydrogenase activity
L2Z08_RS05535	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L2Z08_RS05540	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Z08_RS05550	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2Z08_RS05555	COG1137	ATPase activity
L2Z08_RS05560	COG1538	Outer membrane efflux protein
L2Z08_RS05590	COG4122	O-methyltransferase activity
L2Z08_RS05600	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2Z08_RS05615	COG1522	sequence-specific DNA binding
L2Z08_RS05620	COG5006	permease, DMT superfamily
L2Z08_RS05630	COG1560	Kdo2-lipid A biosynthetic process
L2Z08_RS05645	COG2814	Major facilitator Superfamily
L2Z08_RS05665	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z08_RS05715	COG0583	DNA-binding transcription factor activity
L2Z08_RS05720	COG1914	H( )-stimulated, divalent metal cation uptake system
L2Z08_RS05740	COG4770	biotin carboxylase activity
L2Z08_RS05745	COG0038	chloride channel
L2Z08_RS05765	COG1309	transcriptional regulator
L2Z08_RS05775	COG1063	alcohol dehydrogenase
L2Z08_RS05790	COG0439	Biotin carboxylase
L2Z08_RS05795	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z08_RS05815	COG0864	Transcriptional regulator
L2Z08_RS05825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z08_RS05830	COG1116	anion transmembrane transporter activity
L2Z08_RS05950	COG0590	tRNA wobble adenosine to inosine editing
L2Z08_RS05955	COG2807	transmembrane transport
L2Z08_RS05970	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2Z08_RS05985	COG0789	Transcriptional regulator
L2Z08_RS05995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z08_RS06015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z08_RS06025	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z08_RS06040	COG1012	belongs to the aldehyde dehydrogenase family
L2Z08_RS06045	COG0531	amino acid
L2Z08_RS06050	COG1760	l-serine dehydratase
L2Z08_RS06055	COG1012	belongs to the aldehyde dehydrogenase family
L2Z08_RS06055	COG2030	dehydratase
L2Z08_RS06060	COG3396	Phenylacetate-CoA oxygenase
L2Z08_RS06065	COG3460	Phenylacetate-CoA oxygenase
L2Z08_RS06070	COG3396	Phenylacetate-CoA oxygenase
L2Z08_RS06075	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Z08_RS06080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z08_RS06085	COG1024	Enoyl-CoA hydratase
L2Z08_RS06090	COG1024	Enoyl-CoA hydratase
L2Z08_RS06095	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z08_RS06100	COG0183	Belongs to the thiolase family
L2Z08_RS06105	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L2Z08_RS06110	COG3327	negative regulation of DNA-templated transcription, initiation
L2Z08_RS06120	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z08_RS06155	COG0753	catalase activity
L2Z08_RS06160	COG3038	cytochrome b561
L2Z08_RS06180	COG2267	carboxylic ester hydrolase activity
L2Z08_RS06185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z08_RS06190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z08_RS06195	COG1012	belongs to the aldehyde dehydrogenase family
L2Z08_RS06205	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z08_RS06215	COG1012	belongs to the aldehyde dehydrogenase family
L2Z08_RS06220	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z08_RS06225	COG0583	DNA-binding transcription factor activity
L2Z08_RS06235	COG1414	Transcriptional regulator
L2Z08_RS06240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z08_RS06250	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Z08_RS06255	COG3842	ATPase activity
L2Z08_RS06270	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Z08_RS06275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z08_RS06280	COG2814	Major facilitator Superfamily
L2Z08_RS06285	COG1960	acyl-CoA dehydrogenase activity
L2Z08_RS06300	COG1024	Enoyl-CoA hydratase
L2Z08_RS06330	COG0183	Belongs to the thiolase family
L2Z08_RS06335	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z08_RS06340	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z08_RS06345	COG1024	Enoyl-CoA hydratase
L2Z08_RS06350	COG1960	acyl-CoA dehydrogenase activity
L2Z08_RS06355	COG2814	Major facilitator Superfamily
L2Z08_RS06360	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z08_RS06365	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z08_RS06375	COG2814	Major facilitator Superfamily
L2Z08_RS06385	COG1960	acyl-CoA dehydrogenase activity
L2Z08_RS06400	COG0583	DNA-binding transcription factor activity
L2Z08_RS06415	COG4770	biotin carboxylase activity
L2Z08_RS06420	COG1024	Enoyl-CoA hydratase
L2Z08_RS06425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z08_RS06430	COG1960	acyl-CoA dehydrogenase activity
L2Z08_RS06435	COG1309	transcriptional regulator
L2Z08_RS06440	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z08_RS06460	COG0583	DNA-binding transcription factor activity
L2Z08_RS06510	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z08_RS06530	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Z08_RS06550	COG2205	protein histidine kinase activity
L2Z08_RS06550	COG0784	Response regulator, receiver
L2Z08_RS06570	COG0765	amino acid transport
L2Z08_RS06575	COG0765	amino acid transport
L2Z08_RS06580	COG1126	abc transporter atp-binding protein
L2Z08_RS06585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z08_RS06590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z08_RS06605	COG1280	lysine exporter protein (LysE YggA)
L2Z08_RS06615	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2Z08_RS06620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z08_RS06625	COG1045	serine acetyltransferase
L2Z08_RS06640	COG0583	DNA-binding transcription factor activity
L2Z08_RS06645	COG0625	glutathione transferase activity
L2Z08_RS06650	COG0625	glutathione transferase activity
L2Z08_RS06655	COG0583	DNA-binding transcription factor activity
L2Z08_RS06665	COG1346	cytolysis
L2Z08_RS06685	COG2814	Major facilitator Superfamily
L2Z08_RS06695	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2Z08_RS06700	COG3052	prosthetic group binding
L2Z08_RS06720	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Z08_RS06740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z08_RS06750	COG1294	oxidase, subunit
L2Z08_RS06755	COG1271	oxidase subunit
L2Z08_RS06775	COG0477	Major facilitator Superfamily
L2Z08_RS06795	COG4521	taurine ABC transporter
L2Z08_RS06800	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2Z08_RS06805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z08_RS06810	COG2175	clavaminate synthase activity
L2Z08_RS06820	COG1953	Uracil, thiamine, allantoin
L2Z08_RS06830	COG0583	DNA-binding transcription factor activity
L2Z08_RS06840	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L2Z08_RS06855	COG0640	Transcriptional regulator
L2Z08_RS06860	COG0798	PFAM Bile acid sodium symporter
L2Z08_RS06865	COG0583	DNA-binding transcription factor activity
L2Z08_RS06880	COG3634	alkyl hydroperoxide reductase activity
L2Z08_RS06920	COG0436	Aminotransferase
L2Z08_RS06930	COG0386	Belongs to the glutathione peroxidase family
L2Z08_RS06970	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z08_RS06995	COG0012	GTP binding
L2Z08_RS07000	COG2011	ABC-type metal ion transport system permease component
L2Z08_RS07005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z08_RS07015	COG1464	Belongs to the NlpA lipoprotein family
L2Z08_RS07045	COG0765	amino acid transport
L2Z08_RS07050	COG0765	amino acid transport
L2Z08_RS07055	COG1126	abc transporter atp-binding protein
L2Z08_RS07065	COG1522	sequence-specific DNA binding
L2Z08_RS07100	COG0583	DNA-binding transcription factor activity
L2Z08_RS07110	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z08_RS07120	COG0697	spore germination
L2Z08_RS07145	COG3121	Chaperone
L2Z08_RS07150	COG3539	Fimbrial protein
L2Z08_RS07175	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Z08_RS07175	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Z08_RS07220	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Z08_RS07230	COG2353	YceI-like domain
L2Z08_RS07240	COG3698	Phosphodiester glycosidase
L2Z08_RS07260	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z08_RS07260	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z08_RS07260	COG0506	proline dehydrogenase activity
L2Z08_RS07270	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z08_RS07275	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Z08_RS07295	COG1132	(ABC) transporter
L2Z08_RS07300	COG3122	Protein conserved in bacteria
L2Z08_RS07305	COG3619	membrane
L2Z08_RS07315	COG0640	Transcriptional regulator
L2Z08_RS07325	COG2850	peptidyl-arginine hydroxylation
L2Z08_RS07330	COG0424	maF-like protein
L2Z08_RS07350	COG0191	fructose-bisphosphate aldolase activity
L2Z08_RS07355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z08_RS07370	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z08_RS07380	COG1192	Involved in chromosome partitioning
L2Z08_RS07385	COG1475	DNA binding
L2Z08_RS07390	COG0811	peptide transport
L2Z08_RS07400	COG1132	(ABC) transporter
L2Z08_RS07405	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Z08_RS07425	COG0084	hydrolase, TatD family'
L2Z08_RS07490	COG0776	regulation of translation
L2Z08_RS07530	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Z08_RS07535	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Z08_RS07585	COG0339	signal peptide processing
L2Z08_RS07595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Z08_RS07630	COG0702	epimerase
L2Z08_RS07635	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z08_RS07655	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Z08_RS07685	COG0316	Belongs to the HesB IscA family
L2Z08_RS07690	COG0822	iron-sulfur transferase activity
L2Z08_RS07715	COG0776	regulation of translation
L2Z08_RS07720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z08_RS07725	COG2207	Transcriptional regulator
L2Z08_RS07730	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z08_RS07735	COG1960	acyl-CoA dehydrogenase activity
L2Z08_RS07740	COG1960	acyl-CoA dehydrogenase activity
L2Z08_RS07755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Z08_RS07775	COG4264	IucA IucC family
L2Z08_RS07780	COG4264	IucA IucC family
L2Z08_RS07820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z08_RS07835	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2Z08_RS07865	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Z08_RS07870	COG0730	response to heat
L2Z08_RS07890	COG4773	Receptor
L2Z08_RS07895	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z08_RS07910	COG1131	(ABC) transporter
L2Z08_RS07915	COG0842	Transport permease protein
L2Z08_RS07920	COG0842	Transport permease protein
L2Z08_RS07975	COG2226	methyltransferase
L2Z08_RS08000	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Z08_RS08040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z08_RS08050	COG0133	tryptophan synthase activity
L2Z08_RS08065	COG3706	GGDEF domain
L2Z08_RS08080	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z08_RS08085	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2Z08_RS08090	COG0022	dehydrogenase e1 component
L2Z08_RS08095	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z08_RS08100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z08_RS08110	COG1063	alcohol dehydrogenase
L2Z08_RS08115	COG3781	membrane
L2Z08_RS08125	COG3453	Protein conserved in bacteria
L2Z08_RS08125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z08_RS08140	COG0730	response to heat
L2Z08_RS08155	COG3708	Transcriptional regulator
L2Z08_RS08155	COG2207	Transcriptional regulator
L2Z08_RS08160	COG1733	regulation of RNA biosynthetic process
L2Z08_RS08165	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Z08_RS08175	COG2188	Transcriptional regulator
L2Z08_RS08190	COG4521	taurine ABC transporter
L2Z08_RS08195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z08_RS08215	COG0477	Major facilitator Superfamily
L2Z08_RS08225	COG1027	Aspartate ammonia-lyase
L2Z08_RS08240	COG0583	DNA-binding transcription factor activity
L2Z08_RS08245	COG0583	DNA-binding transcription factor activity
L2Z08_RS08250	COG0183	Belongs to the thiolase family
L2Z08_RS08255	COG2031	fatty acid transporter
L2Z08_RS08260	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z08_RS08270	COG0583	DNA-binding transcription factor activity
L2Z08_RS08285	COG2207	Transcriptional regulator
L2Z08_RS08300	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z08_RS08325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z08_RS08325	COG0543	2 iron, 2 sulfur cluster binding
L2Z08_RS08330	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z08_RS08335	COG4638	Rieske (2fe-2S)
L2Z08_RS08345	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2Z08_RS08350	COG4149	molybdate abc transporter
L2Z08_RS08355	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2Z08_RS08360	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z08_RS08365	COG1535	isochorismatase
L2Z08_RS08365	COG3433	isochorismatase activity
L2Z08_RS08425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z08_RS08440	COG0753	catalase activity
L2Z08_RS08450	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L2Z08_RS08480	COG3539	Fimbrial protein
L2Z08_RS08500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z08_RS08520	COG2072	flavoprotein involved in K transport
L2Z08_RS08530	COG1538	Outer membrane efflux protein
L2Z08_RS08535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z08_RS08540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z08_RS08545	COG0745	RESPONSE REGULATOR receiver
L2Z08_RS08550	COG2205	protein histidine kinase activity
L2Z08_RS08560	COG2207	Transcriptional regulator
L2Z08_RS08575	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z08_RS08625	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2Z08_RS08755	COG0739	heme binding
L2Z08_RS08755	COG0741	lytic transglycosylase activity
L2Z08_RS08755	COG1196	nuclear chromosome segregation
L2Z08_RS08770	COG1598	PFAM Uncharacterised protein family UPF0150
L2Z08_RS08875	COG5410	chromosome segregation
L2Z08_RS09120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z08_RS09140	COG1120	ATPase activity
L2Z08_RS09145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z08_RS09155	COG1064	alcohol dehydrogenase
L2Z08_RS09170	COG2207	Transcriptional regulator
L2Z08_RS09175	COG2084	Dehydrogenase
L2Z08_RS09185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z08_RS09190	COG0583	DNA-binding transcription factor activity
L2Z08_RS09200	COG0129	dihydroxy-acid dehydratase activity
L2Z08_RS09205	COG1012	belongs to the aldehyde dehydrogenase family
L2Z08_RS09220	COG1566	PFAM secretion protein HlyD family protein
L2Z08_RS09250	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z08_RS09280	COG0583	DNA-binding transcription factor activity
L2Z08_RS09295	COG2188	Transcriptional regulator
L2Z08_RS09335	COG3210	domain, Protein
L2Z08_RS09340	COG2831	hemolysin activation secretion protein
L2Z08_RS09360	COG1473	amidohydrolase
L2Z08_RS09370	COG0475	glutathione-regulated potassium exporter activity
L2Z08_RS09370	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z08_RS09380	COG0583	DNA-binding transcription factor activity
L2Z08_RS09385	COG1335	isochorismatase
L2Z08_RS09395	COG1309	transcriptional regulator
L2Z08_RS09425	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L2Z08_RS09435	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z08_RS09435	COG1902	pentaerythritol trinitrate reductase activity
L2Z08_RS09440	COG1846	Transcriptional regulator
L2Z08_RS09460	COG0753	catalase activity
L2Z08_RS09475	COG1012	belongs to the aldehyde dehydrogenase family
L2Z08_RS09490	COG3162	membrane
L2Z08_RS09505	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z08_RS09510	COG1960	acyl-CoA dehydrogenase activity
L2Z08_RS09530	COG1012	belongs to the aldehyde dehydrogenase family
L2Z08_RS09550	COG2186	Transcriptional regulator
L2Z08_RS09560	COG0583	DNA-binding transcription factor activity
L2Z08_RS09565	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z08_RS09570	COG4829	muconolactone delta-isomerase
L2Z08_RS09580	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z08_RS09585	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z08_RS09590	COG0183	Belongs to the thiolase family
L2Z08_RS09595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z08_RS09605	COG1012	belongs to the aldehyde dehydrogenase family
L2Z08_RS09615	COG3733	amine oxidase
L2Z08_RS09625	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z08_RS09635	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z08_RS09645	COG4638	Rieske (2fe-2S)
L2Z08_RS09665	COG0154	amidase activity
L2Z08_RS09675	COG2814	Major facilitator Superfamily
L2Z08_RS09700	COG1960	acyl-CoA dehydrogenase activity
L2Z08_RS09705	COG0583	DNA-binding transcription factor activity
L2Z08_RS09710	COG1414	Transcriptional regulator
L2Z08_RS09725	COG2391	methyltransferase activity
L2Z08_RS09735	COG4993	Dehydrogenase
L2Z08_RS09740	COG3659	wide pore channel activity
L2Z08_RS09745	COG3420	alginic acid biosynthetic process
L2Z08_RS09750	COG0710	3-dehydroquinate dehydratase activity
L2Z08_RS09755	COG3485	protocatechuate 3,4-dioxygenase
L2Z08_RS09760	COG3485	protocatechuate 3,4-dioxygenase
L2Z08_RS09765	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z08_RS09770	COG2271	Major facilitator Superfamily
L2Z08_RS09775	COG0596	Alpha beta hydrolase
L2Z08_RS09780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Z08_RS09785	COG0183	Belongs to the thiolase family
L2Z08_RS09790	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z08_RS09795	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z08_RS09805	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Z08_RS09810	COG2323	membrane
L2Z08_RS09855	COG1902	pentaerythritol trinitrate reductase activity
L2Z08_RS09855	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z08_RS09880	COG0542	response to heat
L2Z08_RS09885	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Z08_RS09915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z08_RS09920	COG0569	domain protein
L2Z08_RS09925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Z08_RS09940	COG4774	siderophore transport
L2Z08_RS09945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Z08_RS09955	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2Z08_RS09975	COG1294	oxidase, subunit
L2Z08_RS09980	COG4890	Cyd operon protein YbgT
L2Z08_RS09995	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2Z08_RS10005	COG0552	protein localization to endoplasmic reticulum
L2Z08_RS10030	COG0516	GMP reductase activity
L2Z08_RS10030	COG0517	IMP dehydrogenase activity
L2Z08_RS10035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z08_RS10040	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Z08_RS10050	COG0583	DNA-binding transcription factor activity
L2Z08_RS10055	COG0024	Methionine aminopeptidase
L2Z08_RS10085	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z08_RS10085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Z08_RS10090	COG1105	Belongs to the carbohydrate kinase PfkB family
L2Z08_RS10095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z08_RS10095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z08_RS10095	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2Z08_RS10115	COG3300	MHYT domain
L2Z08_RS10115	COG5001	Diguanylate cyclase
L2Z08_RS10130	COG2135	peptidase activity
L2Z08_RS10135	COG0659	secondary active sulfate transmembrane transporter activity
L2Z08_RS10155	COG1113	amino acid transport
L2Z08_RS10165	COG1522	sequence-specific DNA binding
L2Z08_RS10190	COG1011	Hydrolase
L2Z08_RS10195	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Z08_RS10205	COG2137	regulation of response to DNA damage stimulus
L2Z08_RS10220	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z08_RS10255	COG0575	Belongs to the CDS family
L2Z08_RS10260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Z08_RS10280	COG3852	Histidine kinase
L2Z08_RS10285	COG2204	response regulator
L2Z08_RS10340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z08_RS10345	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Z08_RS10365	COG0697	spore germination
L2Z08_RS10370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z08_RS10380	COG0303	'Molybdopterin
L2Z08_RS10385	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Z08_RS10385	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Z08_RS10400	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Z08_RS10405	COG0243	molybdopterin cofactor binding
L2Z08_RS10415	COG0243	molybdopterin cofactor binding
L2Z08_RS10420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z08_RS10425	COG2146	nitrite reductase [NAD(P)H] activity
L2Z08_RS10425	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z08_RS10435	COG0745	RESPONSE REGULATOR receiver
L2Z08_RS10440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z08_RS10440	COG1116	anion transmembrane transporter activity
L2Z08_RS10460	COG0511	ligase activity, forming carbon-carbon bonds
L2Z08_RS10475	COG2814	Major facilitator Superfamily
L2Z08_RS10495	COG0069	glutamate synthase activity
L2Z08_RS10515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Z08_RS10525	COG1454	alcohol dehydrogenase
L2Z08_RS10530	COG0824	Thioesterase
L2Z08_RS10540	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z08_RS10555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z08_RS10560	COG2030	dehydratase
L2Z08_RS10570	COG0183	Belongs to the thiolase family
L2Z08_RS10580	COG0583	DNA-binding transcription factor activity
L2Z08_RS10585	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z08_RS10595	COG1522	sequence-specific DNA binding
L2Z08_RS10600	COG3135	benzoate transporter
L2Z08_RS10610	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Z08_RS10635	COG0589	response to stress
L2Z08_RS10640	COG0488	(ABC) transporter
L2Z08_RS10660	COG4773	Receptor
L2Z08_RS10690	COG0668	transmembrane transport
L2Z08_RS10700	COG1309	transcriptional regulator
L2Z08_RS10710	COG2801	Transposase and inactivated derivatives
L2Z08_RS10725	COG1605	Chorismate mutase
L2Z08_RS10735	COG4221	oxidoreductase activity
L2Z08_RS10745	COG0308	aminopeptidase N
L2Z08_RS10765	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
L2Z08_RS10775	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z08_RS10780	COG1454	alcohol dehydrogenase
L2Z08_RS10800	COG0531	amino acid
L2Z08_RS10805	COG4303	Ethanolamine ammonia lyase large subunit
L2Z08_RS10810	COG4302	ethanolamine ammonia-lyase activity
L2Z08_RS10815	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z08_RS10815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z08_RS10820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z08_RS10830	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z08_RS10845	COG0697	spore germination
L2Z08_RS10850	COG1923	regulation of RNA biosynthetic process
L2Z08_RS10860	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Z08_RS10865	COG0802	atpase or kinase
L2Z08_RS10885	COG1187	pseudouridine synthase activity
L2Z08_RS10900	COG0583	DNA-binding transcription factor activity
L2Z08_RS10915	COG2814	Major facilitator Superfamily
L2Z08_RS10920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z08_RS10945	COG0729	surface antigen
L2Z08_RS10965	COG0174	glutamine synthetase
L2Z08_RS10970	COG0745	RESPONSE REGULATOR receiver
L2Z08_RS10975	COG2205	protein histidine kinase activity
L2Z08_RS10985	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2Z08_RS10990	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2Z08_RS11015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z08_RS11020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z08_RS11025	COG1960	acyl-CoA dehydrogenase activity
L2Z08_RS11040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z08_RS11045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z08_RS11065	COG0583	DNA-binding transcription factor activity
L2Z08_RS11080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z08_RS11090	COG3658	cytochrome
L2Z08_RS11095	COG1215	transferase activity, transferring glycosyl groups
L2Z08_RS11100	COG0726	polysaccharide deacetylase
L2Z08_RS11100	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z08_RS11125	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Z08_RS11130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Z08_RS11140	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2Z08_RS11165	COG0305	Participates in initiation and elongation during chromosome replication
L2Z08_RS11170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Z08_RS11180	COG1305	Transglutaminase-like
L2Z08_RS11190	COG2308	Evidence 4 Homologs of previously reported genes of
L2Z08_RS11220	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Z08_RS11225	COG0138	bifunctional purine biosynthesis protein purh
L2Z08_RS11230	COG0151	Belongs to the GarS family
L2Z08_RS11235	COG1464	Belongs to the NlpA lipoprotein family
L2Z08_RS11240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z08_RS11245	COG2011	ABC-type metal ion transport system permease component
L2Z08_RS11250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z08_RS11260	COG1301	dicarboxylic acid transport
L2Z08_RS11290	COG1794	racemase activity, acting on amino acids and derivatives
L2Z08_RS11300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Z08_RS11300	COG3008	intermembrane lipid transfer
L2Z08_RS11305	COG2995	paraquat-inducible protein a
L2Z08_RS11315	COG2985	domain, Protein
L2Z08_RS11345	COG0477	Major facilitator Superfamily
L2Z08_RS11395	COG2186	Transcriptional regulator
L2Z08_RS11405	COG0786	glutamate:sodium symporter activity
L2Z08_RS11410	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Z08_RS11440	COG3111	PFAM Bacterial OB fold (BOF) protein
L2Z08_RS11550	COG1610	YqeY-like protein
L2Z08_RS11555	COG4783	chaperone-mediated protein folding
L2Z08_RS11580	COG1286	toxin biosynthetic process
L2Z08_RS11610	COG0778	Nitroreductase
L2Z08_RS11620	COG0513	Belongs to the DEAD box helicase family
L2Z08_RS11645	COG2363	Small membrane protein
L2Z08_RS11675	COG1234	tRNA 3'-trailer cleavage
L2Z08_RS11680	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2Z08_RS11690	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Z08_RS11700	COG2819	hydrolase of the alpha beta superfamily
L2Z08_RS11705	COG1960	acyl-CoA dehydrogenase activity
L2Z08_RS11710	COG1301	dicarboxylic acid transport
L2Z08_RS11715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Z08_RS11720	COG3139	Protein of unknown function (DUF1315)
L2Z08_RS11725	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Z08_RS11730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Z08_RS11740	COG0494	nUDIX hydrolase
L2Z08_RS11750	COG0642	Histidine kinase
L2Z08_RS11765	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Z08_RS11775	COG1720	tRNA m6t6A37 methyltransferase activity
L2Z08_RS11790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z08_RS11795	COG0826	peptidase U32
L2Z08_RS11800	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z08_RS11810	COG4598	ABC transporter
L2Z08_RS11815	COG4160	amino acid transport
L2Z08_RS11820	COG4215	(ABC) transporter
L2Z08_RS11835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z08_RS11985	COG0582	viral genome integration into host DNA
L2Z08_RS11990	COG1131	(ABC) transporter
L2Z08_RS11995	COG0842	Transport permease protein
L2Z08_RS12010	COG0772	Belongs to the SEDS family
L2Z08_RS12015	COG2951	lytic endotransglycosylase activity
L2Z08_RS12040	COG2207	Transcriptional regulator
L2Z08_RS12055	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Z08_RS12060	COG0024	Methionine aminopeptidase
L2Z08_RS12070	COG2223	nitrite transmembrane transporter activity
L2Z08_RS12080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z08_RS12085	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z08_RS12090	COG1960	acyl-CoA dehydrogenase activity
L2Z08_RS12105	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Z08_RS12110	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Z08_RS12115	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z08_RS12135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z08_RS12140	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2Z08_RS12145	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Z08_RS12180	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Z08_RS12190	COG0174	glutamine synthetase
L2Z08_RS12205	COG0512	Glutamine amidotransferase of anthranilate synthase
L2Z08_RS12210	COG0308	aminopeptidase N
L2Z08_RS12240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2Z08_RS12250	COG0302	gtp cyclohydrolase
L2Z08_RS12275	COG3739	integral membrane protein
L2Z08_RS12290	COG1169	isochorismate synthase
L2Z08_RS12300	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z08_RS12305	COG1132	(ABC) transporter
L2Z08_RS12310	COG1132	(ABC) transporter
L2Z08_RS12325	COG1535	isochorismatase
L2Z08_RS12325	COG3433	isochorismatase activity
L2Z08_RS12330	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z08_RS12335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z08_RS12345	COG4774	siderophore transport
L2Z08_RS12350	COG4607	ABC-type enterochelin transport system periplasmic component
L2Z08_RS12355	COG4604	ABC transporter, ATP-binding protein
L2Z08_RS12360	COG4605	iron ion homeostasis
L2Z08_RS12365	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z08_RS12370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z08_RS12385	COG2964	Protein conserved in bacteria
L2Z08_RS12395	COG1741	Belongs to the pirin family
L2Z08_RS12415	COG1309	transcriptional regulator
L2Z08_RS12425	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z08_RS12430	COG2814	Major facilitator Superfamily
L2Z08_RS12465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z08_RS12465	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2Z08_RS12470	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z08_RS12480	COG1012	belongs to the aldehyde dehydrogenase family
L2Z08_RS12490	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z08_RS12495	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z08_RS12500	COG0583	DNA-binding transcription factor activity
L2Z08_RS12505	COG1113	amino acid transport
L2Z08_RS12525	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L2Z08_RS12525	COG2508	Transcriptional regulator
L2Z08_RS12560	COG2879	small protein
L2Z08_RS12565	COG1966	Carbon starvation protein
L2Z08_RS12610	COG1067	ATP-dependent peptidase activity
L2Z08_RS12615	COG0583	DNA-binding transcription factor activity
L2Z08_RS12640	COG1686	Belongs to the peptidase S11 family
L2Z08_RS12645	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Z08_RS12680	COG0616	signal peptide processing
L2Z08_RS12685	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Z08_RS12695	COG0573	inorganic phosphate transmembrane transporter activity
L2Z08_RS12700	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Z08_RS12705	COG1113	amino acid transport
L2Z08_RS12710	COG3961	Belongs to the TPP enzyme family
L2Z08_RS12715	COG1522	sequence-specific DNA binding
L2Z08_RS12725	COG0076	glutamate decarboxylase activity
L2Z08_RS12730	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z08_RS12740	COG1309	transcriptional regulator
L2Z08_RS12755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z08_RS12790	COG0352	thiamine-phosphate diphosphorylase activity
L2Z08_RS12815	COG0612	Peptidase, M16
L2Z08_RS12825	COG1823	symporter activity
L2Z08_RS12830	COG0583	DNA-binding transcription factor activity
L2Z08_RS12835	COG0477	Major facilitator Superfamily
L2Z08_RS12860	COG1187	pseudouridine synthase activity
L2Z08_RS12875	COG1686	Belongs to the peptidase S11 family
L2Z08_RS12880	COG1252	NADH dehydrogenase
L2Z08_RS12890	COG0415	Belongs to the DNA photolyase family
L2Z08_RS12905	COG1215	transferase activity, transferring glycosyl groups
L2Z08_RS12935	COG2070	2-Nitropropane dioxygenase
L2Z08_RS13125	COG5410	chromosome segregation
L2Z08_RS13330	COG0556	nucleotide-excision repair
L2Z08_RS13350	COG0436	Aminotransferase
L2Z08_RS13380	COG4221	oxidoreductase activity
L2Z08_RS13390	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Z08_RS13395	COG1381	Involved in DNA repair and RecF pathway recombination
L2Z08_RS13405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Z08_RS13420	COG0681	Belongs to the peptidase S26 family
L2Z08_RS13435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z08_RS13455	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Z08_RS13460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2Z08_RS13465	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2Z08_RS13475	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2Z08_RS13480	COG4208	sulfate ABC transporter
L2Z08_RS13485	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2Z08_RS13490	COG0583	DNA-binding transcription factor activity
L2Z08_RS13495	COG4625	pathogenesis
L2Z08_RS13510	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2Z08_RS13525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Z08_RS13535	COG1051	belongs to the nudix hydrolase family
L2Z08_RS13535	COG1056	cytidyltransferase-related domain
L2Z08_RS13540	COG1024	Enoyl-CoA hydratase
L2Z08_RS13550	COG2814	Major facilitator Superfamily
L2Z08_RS13555	COG0047	phosphoribosylformylglycinamidine synthase activity
L2Z08_RS13555	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2Z08_RS13575	COG1473	amidohydrolase
L2Z08_RS13580	COG0824	Thioesterase
L2Z08_RS13600	COG0823	Involved in the tonB-independent uptake of proteins
L2Z08_RS13620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z08_RS13655	COG0628	permease
L2Z08_RS13665	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Z08_RS13670	COG0596	Alpha beta hydrolase
L2Z08_RS13675	COG0616	signal peptide processing
L2Z08_RS13675	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Z08_RS13685	COG0658	competence protein
L2Z08_RS13685	COG2333	competence protein COMEC
L2Z08_RS13690	COG1136	(ABC) transporter
L2Z08_RS13695	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Z08_RS13730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z08_RS13750	COG0463	Glycosyl transferase, family 2
L2Z08_RS13780	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z08_RS13785	COG1280	lysine exporter protein (LysE YggA)
L2Z08_RS13795	COG0019	diaminopimelate decarboxylase activity
L2Z08_RS13805	COG1113	amino acid transport
L2Z08_RS13820	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Z08_RS13830	COG3339	Conserved Protein
L2Z08_RS13835	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2Z08_RS13840	COG0243	molybdopterin cofactor binding
L2Z08_RS13845	COG1929	Belongs to the glycerate kinase type-1 family
L2Z08_RS13860	COG0778	Nitroreductase
L2Z08_RS13890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z08_RS13905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z08_RS13950	COG0589	response to stress
L2Z08_RS13955	COG0659	secondary active sulfate transmembrane transporter activity
L2Z08_RS13965	COG1002	Type II restriction enzyme, methylase subunits
L2Z08_RS13970	COG1061	Type III restriction enzyme res subunit
L2Z08_RS14010	COG0741	lytic transglycosylase activity
L2Z08_RS14030	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z08_RS14040	COG2826	transposase and inactivated derivatives, IS30 family
L2Z08_RS14070	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z08_RS14075	COG1597	lipid kinase activity
L2Z08_RS14090	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2Z08_RS14095	COG0477	Major facilitator Superfamily
L2Z08_RS14145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Z08_RS14150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z08_RS14175	COG0505	Belongs to the CarA family
L2Z08_RS14195	COG0589	response to stress
L2Z08_RS14210	COG2843	Capsule synthesis protein
L2Z08_RS14230	COG2321	neutral zinc metallopeptidase
L2Z08_RS14235	COG2354	Protein conserved in bacteria
L2Z08_RS14255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z08_RS14280	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Z08_RS14285	COG1053	succinate dehydrogenase
L2Z08_RS14290	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Z08_RS14295	COG2009	succinate dehydrogenase
L2Z08_RS14335	COG2921	Belongs to the UPF0250 family
L2Z08_RS14340	COG0321	lipoyl(octanoyl) transferase activity
L2Z08_RS14355	COG0531	amino acid
L2Z08_RS14365	COG1733	regulation of RNA biosynthetic process
L2Z08_RS14370	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Z08_RS14375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Z08_RS14375	COG1648	precorrin-2 dehydrogenase activity
L2Z08_RS14390	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Z08_RS14420	COG0671	phosphoesterase, PA-phosphatase related
L2Z08_RS14425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z08_RS14435	COG1538	Outer membrane efflux protein
L2Z08_RS14440	COG0393	Putative heavy-metal-binding
L2Z08_RS14445	COG0393	Putative heavy-metal-binding
L2Z08_RS14455	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z08_RS14465	COG0525	valine-tRNA ligase activity
L2Z08_RS14485	COG0583	DNA-binding transcription factor activity
L2Z08_RS14490	COG0004	ammonium transporteR
L2Z08_RS14500	COG0642	Histidine kinase
L2Z08_RS14505	COG0745	RESPONSE REGULATOR receiver
L2Z08_RS14510	COG2194	sulfuric ester hydrolase activity
L2Z08_RS14530	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z08_RS14545	COG2315	Protein conserved in bacteria
L2Z08_RS14550	COG0142	geranyltranstransferase activity
L2Z08_RS14555	COG2828	Protein conserved in bacteria
L2Z08_RS14560	COG1113	amino acid transport
L2Z08_RS14580	COG2207	Transcriptional regulator
L2Z08_RS14605	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z08_RS14615	COG0560	Phosphoserine phosphatase
L2Z08_RS14625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z08_RS14635	COG1530	ribonuclease E activity
L2Z08_RS14640	COG0424	maF-like protein
L2Z08_RS14645	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2Z08_RS14650	COG1792	Involved in formation and maintenance of cell shape
L2Z08_RS14655	COG1077	Cell shape determining protein MreB Mrl
L2Z08_RS14660	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z08_RS14670	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z08_RS14705	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2Z08_RS14710	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z08_RS14715	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z08_RS14720	COG1115	amino acid carrier protein
L2Z08_RS14740	COG2814	Major facilitator Superfamily
L2Z08_RS14745	COG1289	transmembrane transporter activity
L2Z08_RS14755	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Z08_RS14795	COG1376	ErfK ybiS ycfS ynhG family protein
L2Z08_RS14800	COG2832	Protein of unknown function (DUF454)
L2Z08_RS14810	COG5510	response to toxic substance
L2Z08_RS14830	COG0840	transmembrane signaling receptor activity
L2Z08_RS14870	COG3422	double-strand break repair
L2Z08_RS14875	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Z08_RS14880	COG3189	MarR family transcriptional regulator
L2Z08_RS14890	COG0354	folic acid binding
L2Z08_RS14895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z08_RS14905	COG0679	Auxin Efflux Carrier
L2Z08_RS14910	COG1902	pentaerythritol trinitrate reductase activity
L2Z08_RS14915	COG4772	TonB-dependent receptor
L2Z08_RS14920	COG2094	Belongs to the DNA glycosylase MPG family
L2Z08_RS14945	COG1217	gtp-binding protein TYPA
L2Z08_RS14950	COG2233	PERMEase
L2Z08_RS14960	COG0833	amino acid
L2Z08_RS14965	COG1690	Belongs to the RtcB family
L2Z08_RS14975	COG2885	chlorophyll binding
L2Z08_RS14975	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L2Z08_RS14985	COG0183	Belongs to the thiolase family
L2Z08_RS15005	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z08_RS15025	COG2207	Transcriptional regulator
L2Z08_RS15030	COG0183	Belongs to the thiolase family
L2Z08_RS15060	COG1272	protein, Hemolysin III
L2Z08_RS15065	COG0477	Major facilitator Superfamily
L2Z08_RS15080	COG0450	alkyl hydroperoxide reductase
L2Z08_RS15100	COG0285	dihydrofolate synthase activity
L2Z08_RS15150	COG2096	Adenosyltransferase
L2Z08_RS15170	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Z08_RS15175	COG0745	RESPONSE REGULATOR receiver
L2Z08_RS15180	COG2205	protein histidine kinase activity
L2Z08_RS15190	COG1960	acyl-CoA dehydrogenase activity
L2Z08_RS15195	COG1960	acyl-CoA dehydrogenase activity
L2Z08_RS15200	COG0583	DNA-binding transcription factor activity
L2Z08_RS15205	COG0625	glutathione transferase activity
L2Z08_RS15270	COG0438	transferase activity, transferring glycosyl groups
L2Z08_RS15275	COG0463	Glycosyl transferase, family 2
L2Z08_RS15280	COG0726	polysaccharide deacetylase
L2Z08_RS15300	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Z08_RS15305	COG2205	protein histidine kinase activity
L2Z08_RS15360	COG1862	Preprotein translocase
L2Z08_RS15370	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2Z08_RS15375	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Z08_RS15385	COG3781	membrane
L2Z08_RS15390	COG0613	PHP domain protein
L2Z08_RS15400	COG2350	Protein conserved in bacteria
L2Z08_RS15430	COG1607	acyl-coa hydrolase
L2Z08_RS15490	COG2199	diguanylate cyclase activity
L2Z08_RS15500	COG1408	metallophosphoesterase
L2Z08_RS15505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z08_RS15515	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Z08_RS15535	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z08_RS15540	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Z08_RS15555	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Z08_RS15565	COG2969	positive regulation of protein catabolic process
L2Z08_RS15585	COG1960	acyl-CoA dehydrogenase activity
L2Z08_RS15590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z08_RS15605	COG1309	transcriptional regulator
L2Z08_RS15610	COG1960	acyl-CoA dehydrogenase activity
L2Z08_RS15655	COG1183	phosphatidylcholine synthase activity
L2Z08_RS15660	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Z08_RS15690	COG0741	lytic transglycosylase activity
L2Z08_RS15690	COG0739	heme binding
L2Z08_RS15690	COG1196	nuclear chromosome segregation
L2Z08_RS15700	COG1702	phosphate starvation-inducible protein PhoH
L2Z08_RS15735	COG1295	ribonuclease BN
L2Z08_RS15740	COG0697	spore germination
L2Z08_RS15745	COG2169	Transcriptional regulator
L2Z08_RS15750	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Z08_RS15795	COG0557	exoribonuclease II activity
L2Z08_RS15800	COG0339	signal peptide processing
L2Z08_RS15805	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2Z08_RS15835	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Z08_RS15840	COG1960	acyl-CoA dehydrogenase activity
L2Z08_RS15995	COG0626	cystathionine gamma-synthase activity
L2Z08_RS16000	COG0433	COG0433 Predicted ATPase
L2Z08_RS16005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z08_RS16005	COG1017	nitric oxide dioxygenase activity
L2Z08_RS16010	COG1959	2 iron, 2 sulfur cluster binding
L2Z08_RS16025	COG1301	dicarboxylic acid transport
L2Z08_RS16030	COG1946	Acyl-CoA thioesterase
L2Z08_RS16050	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2Z08_RS16055	COG1040	competence protein
L2Z08_RS16060	COG0494	nUDIX hydrolase
L2Z08_RS16070	COG0598	Magnesium transport protein CorA
L2Z08_RS16080	COG2854	intermembrane phospholipid transfer
L2Z08_RS16090	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Z08_RS16095	COG1127	ABC transporter
L2Z08_RS16105	COG0513	Belongs to the DEAD box helicase family
L2Z08_RS16125	COG0408	coproporphyrinogen oxidase activity
L2Z08_RS16140	COG1960	acyl-CoA dehydrogenase activity
L2Z08_RS16150	COG1983	PspC domain protein
L2Z08_RS16155	COG0517	IMP dehydrogenase activity
L2Z08_RS16200	COG0583	DNA-binding transcription factor activity
L2Z08_RS16240	COG1012	belongs to the aldehyde dehydrogenase family
L2Z08_RS16250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z08_RS16255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z08_RS16260	COG0833	amino acid
L2Z08_RS16290	COG1192	Involved in chromosome partitioning
L2Z08_RS16295	COG0628	permease
L2Z08_RS16305	COG1289	transmembrane transporter activity
L2Z08_RS16320	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z08_RS16325	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2Z08_RS16335	COG0277	FAD linked oxidase domain protein
L2Z08_RS16340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Z08_RS16365	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Z08_RS16370	COG5380	lipid catabolic process
L2Z08_RS16390	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Z08_RS16440	COG0194	GDP metabolic process
L2Z08_RS16455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z08_RS16475	COG3307	-O-antigen
L2Z08_RS16495	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2Z08_RS16500	COG1704	LemA family
L2Z08_RS16510	COG0493	'glutamate synthase
L2Z08_RS16515	COG0067	glutamate synthase
L2Z08_RS16515	COG0070	glutamate synthase
L2Z08_RS16515	COG0069	glutamate synthase activity
L2Z08_RS16565	COG2226	methyltransferase
L2Z08_RS16580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Z08_RS16585	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Z08_RS16630	COG0833	amino acid
L2Z08_RS16715	COG0488	(ABC) transporter
L2Z08_RS16720	COG2873	o-acetylhomoserine
L2Z08_RS16725	COG4221	oxidoreductase activity
L2Z08_RS16730	COG0659	secondary active sulfate transmembrane transporter activity
L2Z08_RS16755	COG0427	acetyl-CoA hydrolase
L2Z08_RS16785	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Z08_RS16815	COG2329	Antibiotic biosynthesis monooxygenase
L2Z08_RS16830	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Z08_RS16895	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z08_RS16900	COG1733	regulation of RNA biosynthetic process
L2Z08_RS16935	COG0667	Aldo Keto reductase
L2Z08_RS16955	COG0583	DNA-binding transcription factor activity
L2Z08_RS16960	COG2814	Major facilitator Superfamily
L2Z08_RS16990	COG1335	isochorismatase
L2Z08_RS17000	COG1012	belongs to the aldehyde dehydrogenase family
L2Z08_RS17005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z08_RS17015	COG1113	amino acid transport
L2Z08_RS17025	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z08_RS17040	COG2814	Major facilitator Superfamily
L2Z08_RS17050	COG0352	thiamine-phosphate diphosphorylase activity
L2Z08_RS17050	COG0351	phosphomethylpyrimidine kinase
L2Z08_RS17050	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z08_RS17070	COG1309	transcriptional regulator
L2Z08_RS17075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2Z08_RS17095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z08_RS17105	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z08_RS17110	COG3162	membrane
L2Z08_RS17115	COG0784	Response regulator, receiver
L2Z08_RS17115	COG2198	Histidine kinase
L2Z08_RS17115	COG2205	protein histidine kinase activity
L2Z08_RS17140	COG3328	transposase activity
L2Z08_RS17145	COG1522	sequence-specific DNA binding
L2Z08_RS17150	COG1335	isochorismatase
L2Z08_RS17155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z08_RS17165	COG0668	transmembrane transport
L2Z08_RS17170	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z08_RS17175	COG1519	Transferase
L2Z08_RS17180	COG1902	pentaerythritol trinitrate reductase activity
L2Z08_RS17200	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2Z08_RS17225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z08_RS17225	COG0426	domain, Protein
L2Z08_RS17230	COG4774	siderophore transport
L2Z08_RS17235	COG2119	membrane
L2Z08_RS17245	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z08_RS17255	COG4942	peptidase
L2Z08_RS17270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Z08_RS17280	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Z08_RS17300	COG0189	ligase activity
L2Z08_RS17320	COG0708	Exodeoxyribonuclease III
L2Z08_RS17325	COG1393	Belongs to the ArsC family
L2Z08_RS17340	COG3706	GGDEF domain
L2Z08_RS17375	COG2351	hydroxyisourate hydrolase activity
L2Z08_RS17380	COG2233	PERMEase
L2Z08_RS17390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z08_RS17400	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2Z08_RS17405	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z08_RS17415	COG3150	esterase
L2Z08_RS17445	COG2918	glutathione biosynthetic process
L2Z08_RS17460	COG2733	membrane
L2Z08_RS17465	COG0436	Aminotransferase
L2Z08_RS17470	COG0534	Mate efflux family protein
L2Z08_RS17570	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2Z08_RS17575	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Z08_RS17585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2Z08_RS17590	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z08_RS17605	COG0010	Belongs to the arginase family
L2Z08_RS17635	COG2188	Transcriptional regulator
L2Z08_RS17645	COG0523	cobalamin synthesis protein
L2Z08_RS17655	COG1113	amino acid transport
L2Z08_RS17665	COG0625	glutathione transferase activity
L2Z08_RS17685	COG1683	Conserved Protein
L2Z08_RS17690	COG0534	Mate efflux family protein
L2Z08_RS17695	COG0385	Bile acid
L2Z08_RS17700	COG1335	isochorismatase
L2Z08_RS17705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z08_RS17725	COG2116	formate transmembrane transporter activity
L2Z08_RS17730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Z08_RS17735	COG2133	pyrroloquinoline quinone binding
L2Z08_RS17740	COG2983	Belongs to the UPF0260 family
L2Z08_RS17760	COG1194	a g-specific adenine glycosylase
L2Z08_RS17775	COG2818	Glycosylase
L2Z08_RS17780	COG1064	alcohol dehydrogenase
L2Z08_RS17785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z08_RS17800	COG0583	DNA-binding transcription factor activity
L2Z08_RS17805	COG0656	L-ascorbic acid biosynthetic process
L2Z08_RS17810	COG2814	Major facilitator Superfamily
L2Z08_RS17845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z08_RS17860	COG2233	PERMEase
L2Z08_RS17865	COG0583	DNA-binding transcription factor activity
L2Z08_RS17900	COG0733	neurotransmitter:sodium symporter activity
L2Z08_RS17945	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2Z08_RS17950	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2Z08_RS17955	COG0596	Alpha beta hydrolase
L2Z08_RS17980	COG0488	(ABC) transporter
L2Z08_RS17985	COG0586	Pfam SNARE associated Golgi protein
L2Z08_RS17995	COG0187	DNA topoisomerase II activity
L2Z08_RS18005	COG0592	DNA-directed DNA polymerase activity
L2Z08_RS18030	COG0706	membrane insertase activity
L2Z08_RS18045	COG1230	cation diffusion facilitator family transporter
L2Z08_RS18050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z08_RS18065	COG0402	S-adenosylhomocysteine deaminase activity
L2Z08_RS18075	COG0754	glutathionylspermidine amidase activity
L2Z08_RS18085	COG0861	Integral membrane protein TerC family
L2Z08_RS18090	COG0671	phosphoesterase, PA-phosphatase related
L2Z08_RS18100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Z08_RS18115	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Z08_RS18120	COG2951	lytic endotransglycosylase activity
L2Z08_RS18150	COG0583	DNA-binding transcription factor activity
L2Z08_RS18170	COG0657	acetylesterase activity
L2Z08_RS18175	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2Z08_RS18215	COG1047	Peptidyl-prolyl cis-trans
L2Z08_RS18225	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Z08_RS18230	COG0196	riboflavin kinase activity
L2Z08_RS18240	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2Z08_RS18245	COG1309	transcriptional regulator
L2Z08_RS18250	COG1116	anion transmembrane transporter activity
L2Z08_RS18255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z08_RS18260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z08_RS18265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z08_RS18270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z08_RS18290	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z08_RS18295	COG0546	phosphoglycolate phosphatase activity
L2Z08_RS18355	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2Z08_RS18360	COG0728	peptidoglycan biosynthetic process
L2Z08_RS18390	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z08_RS18400	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L2Z08_RS18405	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L2Z08_RS18410	COG2089	acid synthase
L2Z08_RS18420	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z08_RS18425	COG1083	cytidylyl-transferase
L2Z08_RS18430	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z08_RS18440	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z08_RS18475	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L2Z08_RS18490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L2Z08_RS18505	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Z08_RS18520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z08_RS18525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z08_RS18535	COG2186	Transcriptional regulator
L2Z08_RS18545	COG0277	FAD linked oxidase domain protein
L2Z08_RS18550	COG1448	Aminotransferase
L2Z08_RS18560	COG1802	Transcriptional regulator
L2Z08_RS18575	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2Z08_RS18615	COG2801	Transposase and inactivated derivatives
L2Z08_RS18670	COG0564	pseudouridine synthase activity
L2Z08_RS18710	COG0251	oxidation-reduction process
L2Z08_RS18715	COG1113	amino acid transport
L2Z08_RS18720	COG1113	amino acid transport
L2Z08_RS18740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z08_RS18745	COG1960	acyl-CoA dehydrogenase activity
L2Z08_RS18750	COG1024	Enoyl-CoA hydratase
L2Z08_RS18755	COG1024	Enoyl-CoA hydratase
L2Z08_RS18760	COG0477	Major facilitator Superfamily
L2Z08_RS18765	COG3916	Acyl-homoserine-lactone synthase
L2Z08_RS18775	COG2197	response regulator
L2Z08_RS18785	COG1960	acyl-CoA dehydrogenase activity
L2Z08_RS18790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z08_RS18790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Z08_RS18790	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
L2Z08_RS18790	COG3321	synthase
L2Z08_RS18830	COG0271	Belongs to the BolA IbaG family
L2Z08_RS18840	COG1192	Involved in chromosome partitioning
L2Z08_RS18855	COG0586	Pfam SNARE associated Golgi protein
L2Z08_RS18860	COG2259	Doxx family
L2Z08_RS18865	COG4399	Belongs to the UPF0754 family
L2Z08_RS18870	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z08_RS18870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z08_RS18915	COG0281	malic enzyme
L2Z08_RS18920	COG2837	iron assimilation
L2Z08_RS18925	COG1280	lysine exporter protein (LysE YggA)
L2Z08_RS18930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Z08_RS18935	COG1121	(ABC) transporter
L2Z08_RS19005	COG0386	Belongs to the glutathione peroxidase family
L2Z08_RS19020	COG1309	transcriptional regulator
L2Z08_RS19025	COG0697	spore germination
L2Z08_RS19035	COG0758	DNA mediated transformation