locus-tag	class	description
L2Z21_RS00020	COG0302	gtp cyclohydrolase
L2Z21_RS00030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2Z21_RS00065	COG0512	Glutamine amidotransferase of anthranilate synthase
L2Z21_RS00080	COG0174	glutamine synthetase
L2Z21_RS00090	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Z21_RS00125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Z21_RS00130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2Z21_RS00140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z21_RS00160	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z21_RS00165	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Z21_RS00170	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Z21_RS00185	COG1960	acyl-CoA dehydrogenase activity
L2Z21_RS00190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z21_RS00195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z21_RS00205	COG2223	nitrite transmembrane transporter activity
L2Z21_RS00215	COG0024	Methionine aminopeptidase
L2Z21_RS00220	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Z21_RS00235	COG2207	Transcriptional regulator
L2Z21_RS00260	COG2951	lytic endotransglycosylase activity
L2Z21_RS00265	COG0772	Belongs to the SEDS family
L2Z21_RS00280	COG0842	Transport permease protein
L2Z21_RS00285	COG1131	(ABC) transporter
L2Z21_RS00330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z21_RS00345	COG4215	(ABC) transporter
L2Z21_RS00350	COG4160	amino acid transport
L2Z21_RS00355	COG4598	ABC transporter
L2Z21_RS00365	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z21_RS00370	COG0826	peptidase U32
L2Z21_RS00375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z21_RS00390	COG1720	tRNA m6t6A37 methyltransferase activity
L2Z21_RS00400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Z21_RS00415	COG0642	Histidine kinase
L2Z21_RS00425	COG0494	nUDIX hydrolase
L2Z21_RS00435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Z21_RS00440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Z21_RS00445	COG3139	Protein of unknown function (DUF1315)
L2Z21_RS00450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Z21_RS00455	COG1301	dicarboxylic acid transport
L2Z21_RS00460	COG1960	acyl-CoA dehydrogenase activity
L2Z21_RS00465	COG2819	hydrolase of the alpha beta superfamily
L2Z21_RS00475	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Z21_RS00485	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2Z21_RS00490	COG1234	tRNA 3'-trailer cleavage
L2Z21_RS00520	COG2363	Small membrane protein
L2Z21_RS00550	COG0513	Belongs to the DEAD box helicase family
L2Z21_RS00560	COG0778	Nitroreductase
L2Z21_RS00590	COG1286	toxin biosynthetic process
L2Z21_RS00615	COG4783	chaperone-mediated protein folding
L2Z21_RS00620	COG1610	YqeY-like protein
L2Z21_RS00720	COG3111	PFAM Bacterial OB fold (BOF) protein
L2Z21_RS00745	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Z21_RS00750	COG0786	glutamate:sodium symporter activity
L2Z21_RS00760	COG2186	Transcriptional regulator
L2Z21_RS00810	COG0477	Major facilitator Superfamily
L2Z21_RS00840	COG2985	domain, Protein
L2Z21_RS00850	COG2995	paraquat-inducible protein a
L2Z21_RS00855	COG3008	intermembrane lipid transfer
L2Z21_RS00855	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Z21_RS00865	COG1794	racemase activity, acting on amino acids and derivatives
L2Z21_RS00895	COG1301	dicarboxylic acid transport
L2Z21_RS00905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z21_RS00910	COG2011	ABC-type metal ion transport system permease component
L2Z21_RS00915	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z21_RS00920	COG1464	Belongs to the NlpA lipoprotein family
L2Z21_RS00925	COG0151	Belongs to the GarS family
L2Z21_RS00930	COG0138	bifunctional purine biosynthesis protein purh
L2Z21_RS00935	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Z21_RS00965	COG2308	Evidence 4 Homologs of previously reported genes of
L2Z21_RS00975	COG1305	Transglutaminase-like
L2Z21_RS00985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Z21_RS00990	COG0305	Participates in initiation and elongation during chromosome replication
L2Z21_RS01020	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2Z21_RS01030	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Z21_RS01035	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Z21_RS01060	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z21_RS01060	COG0726	polysaccharide deacetylase
L2Z21_RS01065	COG1215	transferase activity, transferring glycosyl groups
L2Z21_RS01070	COG3658	cytochrome
L2Z21_RS01080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z21_RS01095	COG0583	DNA-binding transcription factor activity
L2Z21_RS01115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z21_RS01120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z21_RS01135	COG1960	acyl-CoA dehydrogenase activity
L2Z21_RS01140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z21_RS01145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z21_RS01170	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2Z21_RS01175	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2Z21_RS01185	COG2205	protein histidine kinase activity
L2Z21_RS01190	COG0745	RESPONSE REGULATOR receiver
L2Z21_RS01195	COG0174	glutamine synthetase
L2Z21_RS01215	COG0729	surface antigen
L2Z21_RS01240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z21_RS01245	COG2814	Major facilitator Superfamily
L2Z21_RS01260	COG0583	DNA-binding transcription factor activity
L2Z21_RS01275	COG1187	pseudouridine synthase activity
L2Z21_RS01295	COG0802	atpase or kinase
L2Z21_RS01300	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Z21_RS01310	COG1923	regulation of RNA biosynthetic process
L2Z21_RS01315	COG0697	spore germination
L2Z21_RS01330	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z21_RS01340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z21_RS01345	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z21_RS01345	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z21_RS01350	COG4302	ethanolamine ammonia-lyase activity
L2Z21_RS01355	COG4303	Ethanolamine ammonia lyase large subunit
L2Z21_RS01360	COG0531	amino acid
L2Z21_RS01380	COG1454	alcohol dehydrogenase
L2Z21_RS01385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z21_RS01395	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
L2Z21_RS01415	COG0308	aminopeptidase N
L2Z21_RS01425	COG4221	oxidoreductase activity
L2Z21_RS01435	COG1605	Chorismate mutase
L2Z21_RS01455	COG1309	transcriptional regulator
L2Z21_RS01465	COG0668	transmembrane transport
L2Z21_RS01495	COG4773	Receptor
L2Z21_RS01515	COG0488	(ABC) transporter
L2Z21_RS01520	COG0589	response to stress
L2Z21_RS01545	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Z21_RS01555	COG3135	benzoate transporter
L2Z21_RS01560	COG1522	sequence-specific DNA binding
L2Z21_RS01570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z21_RS01575	COG0583	DNA-binding transcription factor activity
L2Z21_RS01585	COG0183	Belongs to the thiolase family
L2Z21_RS01595	COG2030	dehydratase
L2Z21_RS01600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z21_RS01615	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z21_RS01625	COG0824	Thioesterase
L2Z21_RS01630	COG1454	alcohol dehydrogenase
L2Z21_RS01640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Z21_RS01660	COG0069	glutamate synthase activity
L2Z21_RS01680	COG2814	Major facilitator Superfamily
L2Z21_RS01695	COG0511	ligase activity, forming carbon-carbon bonds
L2Z21_RS01715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z21_RS01715	COG1116	anion transmembrane transporter activity
L2Z21_RS01720	COG0745	RESPONSE REGULATOR receiver
L2Z21_RS01730	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z21_RS01730	COG2146	nitrite reductase [NAD(P)H] activity
L2Z21_RS01735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z21_RS01740	COG0243	molybdopterin cofactor binding
L2Z21_RS01750	COG0243	molybdopterin cofactor binding
L2Z21_RS01755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Z21_RS01770	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Z21_RS01770	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Z21_RS01775	COG0303	'Molybdopterin
L2Z21_RS01785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z21_RS01790	COG0697	spore germination
L2Z21_RS01810	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Z21_RS01880	COG2204	response regulator
L2Z21_RS01885	COG3852	Histidine kinase
L2Z21_RS01905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Z21_RS01910	COG0575	Belongs to the CDS family
L2Z21_RS01945	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z21_RS01960	COG2137	regulation of response to DNA damage stimulus
L2Z21_RS01970	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Z21_RS01975	COG1011	Hydrolase
L2Z21_RS02000	COG1522	sequence-specific DNA binding
L2Z21_RS02010	COG1113	amino acid transport
L2Z21_RS02030	COG0659	secondary active sulfate transmembrane transporter activity
L2Z21_RS02035	COG2135	peptidase activity
L2Z21_RS02045	COG4372	Transposase
L2Z21_RS02065	COG3300	MHYT domain
L2Z21_RS02065	COG5001	Diguanylate cyclase
L2Z21_RS02085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z21_RS02085	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2Z21_RS02085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z21_RS02090	COG1105	Belongs to the carbohydrate kinase PfkB family
L2Z21_RS02095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Z21_RS02095	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z21_RS02125	COG0024	Methionine aminopeptidase
L2Z21_RS02130	COG0583	DNA-binding transcription factor activity
L2Z21_RS02140	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Z21_RS02145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z21_RS02150	COG0516	GMP reductase activity
L2Z21_RS02150	COG0517	IMP dehydrogenase activity
L2Z21_RS02175	COG0552	protein localization to endoplasmic reticulum
L2Z21_RS02185	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2Z21_RS02200	COG4890	Cyd operon protein YbgT
L2Z21_RS02205	COG1294	oxidase, subunit
L2Z21_RS02220	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2Z21_RS02230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Z21_RS02235	COG4774	siderophore transport
L2Z21_RS02250	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Z21_RS02255	COG0569	domain protein
L2Z21_RS02260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z21_RS02290	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Z21_RS02295	COG0542	response to heat
L2Z21_RS02320	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z21_RS02320	COG1902	pentaerythritol trinitrate reductase activity
L2Z21_RS02365	COG2323	membrane
L2Z21_RS02370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Z21_RS02380	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z21_RS02385	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z21_RS02390	COG0183	Belongs to the thiolase family
L2Z21_RS02395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Z21_RS02400	COG0596	Alpha beta hydrolase
L2Z21_RS02405	COG2271	Major facilitator Superfamily
L2Z21_RS02410	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z21_RS02415	COG3485	protocatechuate 3,4-dioxygenase
L2Z21_RS02420	COG3485	protocatechuate 3,4-dioxygenase
L2Z21_RS02425	COG0710	3-dehydroquinate dehydratase activity
L2Z21_RS02430	COG3420	alginic acid biosynthetic process
L2Z21_RS02435	COG3659	wide pore channel activity
L2Z21_RS02440	COG4993	Dehydrogenase
L2Z21_RS02450	COG2391	methyltransferase activity
L2Z21_RS02465	COG1414	Transcriptional regulator
L2Z21_RS02470	COG0583	DNA-binding transcription factor activity
L2Z21_RS02475	COG1960	acyl-CoA dehydrogenase activity
L2Z21_RS02500	COG2814	Major facilitator Superfamily
L2Z21_RS02510	COG0154	amidase activity
L2Z21_RS02530	COG4638	Rieske (2fe-2S)
L2Z21_RS02540	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_RS02550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z21_RS02560	COG3733	amine oxidase
L2Z21_RS02570	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_RS02580	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z21_RS02585	COG0183	Belongs to the thiolase family
L2Z21_RS02590	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z21_RS02595	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z21_RS02605	COG4829	muconolactone delta-isomerase
L2Z21_RS02610	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z21_RS02615	COG0583	DNA-binding transcription factor activity
L2Z21_RS02625	COG2186	Transcriptional regulator
L2Z21_RS02645	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_RS02665	COG1960	acyl-CoA dehydrogenase activity
L2Z21_RS02670	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_RS02685	COG3162	membrane
L2Z21_RS02700	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_RS02715	COG0753	catalase activity
L2Z21_RS02740	COG1846	Transcriptional regulator
L2Z21_RS02745	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z21_RS02745	COG1902	pentaerythritol trinitrate reductase activity
L2Z21_RS02755	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L2Z21_RS02785	COG1309	transcriptional regulator
L2Z21_RS02795	COG1335	isochorismatase
L2Z21_RS02800	COG0583	DNA-binding transcription factor activity
L2Z21_RS02810	COG0475	glutathione-regulated potassium exporter activity
L2Z21_RS02810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z21_RS02820	COG1473	amidohydrolase
L2Z21_RS02835	COG4372	Transposase
L2Z21_RS02855	COG3210	domain, Protein
L2Z21_RS02885	COG2188	Transcriptional regulator
L2Z21_RS02900	COG0583	DNA-binding transcription factor activity
L2Z21_RS02930	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z21_RS02960	COG1566	PFAM secretion protein HlyD family protein
L2Z21_RS02975	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_RS02980	COG0129	dihydroxy-acid dehydratase activity
L2Z21_RS02990	COG0583	DNA-binding transcription factor activity
L2Z21_RS02995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z21_RS03005	COG2084	Dehydrogenase
L2Z21_RS03010	COG2207	Transcriptional regulator
L2Z21_RS03025	COG1064	alcohol dehydrogenase
L2Z21_RS03035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z21_RS03040	COG1120	ATPase activity
L2Z21_RS03060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z21_RS03185	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2Z21_RS03200	COG3293	Transposase
L2Z21_RS03245	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_RS03260	COG2207	Transcriptional regulator
L2Z21_RS03270	COG2205	protein histidine kinase activity
L2Z21_RS03275	COG0745	RESPONSE REGULATOR receiver
L2Z21_RS03280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z21_RS03285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z21_RS03290	COG1538	Outer membrane efflux protein
L2Z21_RS03300	COG2072	flavoprotein involved in K transport
L2Z21_RS03320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z21_RS03335	COG3539	Fimbrial protein
L2Z21_RS03360	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L2Z21_RS03370	COG0753	catalase activity
L2Z21_RS03385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z21_RS03445	COG1535	isochorismatase
L2Z21_RS03445	COG3433	isochorismatase activity
L2Z21_RS03450	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_RS03455	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2Z21_RS03460	COG4149	molybdate abc transporter
L2Z21_RS03465	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2Z21_RS03475	COG4638	Rieske (2fe-2S)
L2Z21_RS03480	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z21_RS03485	COG0543	2 iron, 2 sulfur cluster binding
L2Z21_RS03485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z21_RS03510	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_RS03525	COG2207	Transcriptional regulator
L2Z21_RS03530	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_RS03535	COG2610	gluconate transmembrane transporter activity
L2Z21_RS03545	COG0583	DNA-binding transcription factor activity
L2Z21_RS03555	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z21_RS03560	COG2031	fatty acid transporter
L2Z21_RS03565	COG0183	Belongs to the thiolase family
L2Z21_RS03570	COG0583	DNA-binding transcription factor activity
L2Z21_RS03575	COG0583	DNA-binding transcription factor activity
L2Z21_RS03590	COG1027	Aspartate ammonia-lyase
L2Z21_RS03600	COG0477	Major facilitator Superfamily
L2Z21_RS03620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z21_RS03625	COG4521	taurine ABC transporter
L2Z21_RS03640	COG2188	Transcriptional regulator
L2Z21_RS03650	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Z21_RS03655	COG1733	regulation of RNA biosynthetic process
L2Z21_RS03660	COG2207	Transcriptional regulator
L2Z21_RS03660	COG3708	Transcriptional regulator
L2Z21_RS03675	COG0730	response to heat
L2Z21_RS03690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z21_RS03690	COG3453	Protein conserved in bacteria
L2Z21_RS03700	COG3781	membrane
L2Z21_RS03705	COG1063	alcohol dehydrogenase
L2Z21_RS03715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z21_RS03720	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z21_RS03725	COG0022	dehydrogenase e1 component
L2Z21_RS03730	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2Z21_RS03735	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z21_RS03750	COG3706	GGDEF domain
L2Z21_RS03765	COG0133	tryptophan synthase activity
L2Z21_RS03775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z21_RS03810	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Z21_RS03835	COG2226	methyltransferase
L2Z21_RS03890	COG0842	Transport permease protein
L2Z21_RS03895	COG0842	Transport permease protein
L2Z21_RS03900	COG1131	(ABC) transporter
L2Z21_RS03915	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z21_RS03920	COG4773	Receptor
L2Z21_RS03940	COG0730	response to heat
L2Z21_RS03945	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Z21_RS03965	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2Z21_RS03980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z21_RS04020	COG4264	IucA IucC family
L2Z21_RS04025	COG4264	IucA IucC family
L2Z21_RS04045	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Z21_RS04060	COG1960	acyl-CoA dehydrogenase activity
L2Z21_RS04065	COG1960	acyl-CoA dehydrogenase activity
L2Z21_RS04070	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z21_RS04075	COG2207	Transcriptional regulator
L2Z21_RS04080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z21_RS04085	COG0776	regulation of translation
L2Z21_RS04110	COG0822	iron-sulfur transferase activity
L2Z21_RS04115	COG0316	Belongs to the HesB IscA family
L2Z21_RS04145	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Z21_RS04165	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z21_RS04170	COG0702	epimerase
L2Z21_RS04205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Z21_RS04215	COG0339	signal peptide processing
L2Z21_RS04265	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Z21_RS04270	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Z21_RS04300	COG0776	regulation of translation
L2Z21_RS04365	COG0084	hydrolase, TatD family'
L2Z21_RS04385	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Z21_RS04390	COG1132	(ABC) transporter
L2Z21_RS04400	COG0811	peptide transport
L2Z21_RS04405	COG1475	DNA binding
L2Z21_RS04410	COG1192	Involved in chromosome partitioning
L2Z21_RS04420	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z21_RS04435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z21_RS04440	COG0191	fructose-bisphosphate aldolase activity
L2Z21_RS04460	COG0424	maF-like protein
L2Z21_RS04465	COG2850	peptidyl-arginine hydroxylation
L2Z21_RS04475	COG0640	Transcriptional regulator
L2Z21_RS04485	COG3619	membrane
L2Z21_RS04490	COG3122	Protein conserved in bacteria
L2Z21_RS04495	COG1132	(ABC) transporter
L2Z21_RS04515	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Z21_RS04530	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z21_RS04540	COG0506	proline dehydrogenase activity
L2Z21_RS04540	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z21_RS04540	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z21_RS04545	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2Z21_RS04560	COG3698	Phosphodiester glycosidase
L2Z21_RS04570	COG2353	YceI-like domain
L2Z21_RS04580	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Z21_RS04625	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Z21_RS04625	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Z21_RS04650	COG3539	Fimbrial protein
L2Z21_RS04655	COG3121	Chaperone
L2Z21_RS04680	COG0697	spore germination
L2Z21_RS04690	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z21_RS04700	COG0583	DNA-binding transcription factor activity
L2Z21_RS04745	COG1522	sequence-specific DNA binding
L2Z21_RS04755	COG1126	abc transporter atp-binding protein
L2Z21_RS04760	COG0765	amino acid transport
L2Z21_RS04765	COG0765	amino acid transport
L2Z21_RS04795	COG1464	Belongs to the NlpA lipoprotein family
L2Z21_RS04805	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z21_RS04810	COG2011	ABC-type metal ion transport system permease component
L2Z21_RS04815	COG0012	GTP binding
L2Z21_RS04840	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z21_RS04880	COG0386	Belongs to the glutathione peroxidase family
L2Z21_RS04890	COG0436	Aminotransferase
L2Z21_RS04930	COG3634	alkyl hydroperoxide reductase activity
L2Z21_RS04945	COG0583	DNA-binding transcription factor activity
L2Z21_RS04950	COG0798	PFAM Bile acid sodium symporter
L2Z21_RS04955	COG0640	Transcriptional regulator
L2Z21_RS04970	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L2Z21_RS04990	COG1953	Uracil, thiamine, allantoin
L2Z21_RS05000	COG2175	clavaminate synthase activity
L2Z21_RS05005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z21_RS05010	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2Z21_RS05015	COG4521	taurine ABC transporter
L2Z21_RS05025	COG0477	Major facilitator Superfamily
L2Z21_RS05050	COG1271	oxidase subunit
L2Z21_RS05055	COG1294	oxidase, subunit
L2Z21_RS05065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z21_RS05085	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Z21_RS05105	COG3052	prosthetic group binding
L2Z21_RS05110	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2Z21_RS05120	COG2814	Major facilitator Superfamily
L2Z21_RS05140	COG1346	cytolysis
L2Z21_RS05150	COG0583	DNA-binding transcription factor activity
L2Z21_RS05155	COG0625	glutathione transferase activity
L2Z21_RS05160	COG0625	glutathione transferase activity
L2Z21_RS05165	COG0583	DNA-binding transcription factor activity
L2Z21_RS05180	COG1045	serine acetyltransferase
L2Z21_RS05185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z21_RS05190	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2Z21_RS05200	COG1280	lysine exporter protein (LysE YggA)
L2Z21_RS05215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z21_RS05220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z21_RS05225	COG1126	abc transporter atp-binding protein
L2Z21_RS05230	COG0765	amino acid transport
L2Z21_RS05235	COG0765	amino acid transport
L2Z21_RS05255	COG2205	protein histidine kinase activity
L2Z21_RS05255	COG0784	Response regulator, receiver
L2Z21_RS05275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Z21_RS05295	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_RS05345	COG0583	DNA-binding transcription factor activity
L2Z21_RS05365	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z21_RS05370	COG1309	transcriptional regulator
L2Z21_RS05375	COG1960	acyl-CoA dehydrogenase activity
L2Z21_RS05380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z21_RS05385	COG1024	Enoyl-CoA hydratase
L2Z21_RS05390	COG4770	biotin carboxylase activity
L2Z21_RS05400	COG0583	DNA-binding transcription factor activity
L2Z21_RS05415	COG1960	acyl-CoA dehydrogenase activity
L2Z21_RS05425	COG2814	Major facilitator Superfamily
L2Z21_RS05435	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z21_RS05440	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z21_RS05445	COG2814	Major facilitator Superfamily
L2Z21_RS05450	COG1960	acyl-CoA dehydrogenase activity
L2Z21_RS05455	COG1024	Enoyl-CoA hydratase
L2Z21_RS05460	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_RS05465	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z21_RS05470	COG0183	Belongs to the thiolase family
L2Z21_RS05480	COG2814	Major facilitator Superfamily
L2Z21_RS05490	COG1024	Enoyl-CoA hydratase
L2Z21_RS05505	COG1960	acyl-CoA dehydrogenase activity
L2Z21_RS05510	COG2814	Major facilitator Superfamily
L2Z21_RS05515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z21_RS05520	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Z21_RS05535	COG3842	ATPase activity
L2Z21_RS05540	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Z21_RS05550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z21_RS05555	COG1414	Transcriptional regulator
L2Z21_RS05565	COG0583	DNA-binding transcription factor activity
L2Z21_RS05570	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z21_RS05575	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_RS05585	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z21_RS05595	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_RS05600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z21_RS05605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z21_RS05610	COG2267	carboxylic ester hydrolase activity
L2Z21_RS05630	COG3038	cytochrome b561
L2Z21_RS05635	COG0753	catalase activity
L2Z21_RS05670	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z21_RS05680	COG3327	negative regulation of DNA-templated transcription, initiation
L2Z21_RS05685	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L2Z21_RS05690	COG0183	Belongs to the thiolase family
L2Z21_RS05695	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z21_RS05700	COG1024	Enoyl-CoA hydratase
L2Z21_RS05705	COG1024	Enoyl-CoA hydratase
L2Z21_RS05710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z21_RS05715	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Z21_RS05720	COG3396	Phenylacetate-CoA oxygenase
L2Z21_RS05725	COG3460	Phenylacetate-CoA oxygenase
L2Z21_RS05730	COG3396	Phenylacetate-CoA oxygenase
L2Z21_RS05735	COG2030	dehydratase
L2Z21_RS05735	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_RS05740	COG1760	l-serine dehydratase
L2Z21_RS05745	COG0531	amino acid
L2Z21_RS05750	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_RS05765	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z21_RS05775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z21_RS05795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z21_RS05805	COG0789	Transcriptional regulator
L2Z21_RS05815	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2Z21_RS05830	COG2807	transmembrane transport
L2Z21_RS05835	COG0590	tRNA wobble adenosine to inosine editing
L2Z21_RS05955	COG1116	anion transmembrane transporter activity
L2Z21_RS05960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z21_RS05970	COG0864	Transcriptional regulator
L2Z21_RS05990	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z21_RS05995	COG0439	Biotin carboxylase
L2Z21_RS06020	COG1309	transcriptional regulator
L2Z21_RS06040	COG0038	chloride channel
L2Z21_RS06045	COG4770	biotin carboxylase activity
L2Z21_RS06065	COG1914	H( )-stimulated, divalent metal cation uptake system
L2Z21_RS06070	COG0583	DNA-binding transcription factor activity
L2Z21_RS06110	COG4372	Transposase
L2Z21_RS06140	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z21_RS06160	COG2814	Major facilitator Superfamily
L2Z21_RS06175	COG1560	Kdo2-lipid A biosynthetic process
L2Z21_RS06185	COG5006	permease, DMT superfamily
L2Z21_RS06190	COG1522	sequence-specific DNA binding
L2Z21_RS06205	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2Z21_RS06215	COG4122	O-methyltransferase activity
L2Z21_RS06260	COG4372	Transposase
L2Z21_RS06270	COG1137	ATPase activity
L2Z21_RS06275	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2Z21_RS06285	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Z21_RS06290	COG0517	IMP dehydrogenase activity
L2Z21_RS06290	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L2Z21_RS06325	COG2814	Major facilitator Superfamily
L2Z21_RS06360	COG1278	Cold shock
L2Z21_RS06395	COG1570	exodeoxyribonuclease VII activity
L2Z21_RS06445	COG0583	DNA-binding transcription factor activity
L2Z21_RS06455	COG4638	Rieske (2fe-2S)
L2Z21_RS06460	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z21_RS06465	COG0543	2 iron, 2 sulfur cluster binding
L2Z21_RS06465	COG0633	Ferredoxin
L2Z21_RS06470	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_RS06475	COG3135	benzoate transporter
L2Z21_RS06480	COG2814	Major facilitator Superfamily
L2Z21_RS06495	COG1643	Atp-dependent helicase
L2Z21_RS06500	COG0450	alkyl hydroperoxide reductase
L2Z21_RS06510	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2Z21_RS06520	COG3634	alkyl hydroperoxide reductase activity
L2Z21_RS06540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2Z21_RS06545	COG0625	glutathione transferase activity
L2Z21_RS06555	COG2885	chlorophyll binding
L2Z21_RS06590	COG0542	response to heat
L2Z21_RS06605	COG1765	OsmC-like protein
L2Z21_RS06625	COG0667	Aldo Keto reductase
L2Z21_RS06640	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Z21_RS06650	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Z21_RS06660	COG0527	aspartate kinase activity
L2Z21_RS06670	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2Z21_RS06680	COG3038	cytochrome b561
L2Z21_RS06685	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2Z21_RS06690	COG2252	PERMEase
L2Z21_RS06700	COG2072	flavoprotein involved in K transport
L2Z21_RS06715	COG1741	Belongs to the pirin family
L2Z21_RS06720	COG1309	transcriptional regulator
L2Z21_RS06730	COG0300	oxidoreductase activity
L2Z21_RS06830	COG2186	Transcriptional regulator
L2Z21_RS06835	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_RS06845	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z21_RS06850	COG2271	Major facilitator Superfamily
L2Z21_RS06855	COG2721	sulfolactate sulfo-lyase activity
L2Z21_RS06860	COG0697	spore germination
L2Z21_RS06875	COG1113	amino acid transport
L2Z21_RS06895	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_RS06915	COG0531	amino acid
L2Z21_RS06925	COG1113	amino acid transport
L2Z21_RS06965	COG3209	COG3209 Rhs family protein
L2Z21_RS06995	COG4269	membrane
L2Z21_RS07010	COG1902	pentaerythritol trinitrate reductase activity
L2Z21_RS07010	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z21_RS07020	COG3706	GGDEF domain
L2Z21_RS07020	COG5001	Diguanylate cyclase
L2Z21_RS07020	COG4251	negative regulation of phosphorylation
L2Z21_RS07020	COG2203	Gaf domain
L2Z21_RS07030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z21_RS07050	COG4172	Belongs to the ABC transporter superfamily
L2Z21_RS07055	COG4239	(ABC) transporter, permease
L2Z21_RS07060	COG4174	ABC transporter (Permease)
L2Z21_RS07070	COG0741	lytic transglycosylase activity
L2Z21_RS07070	COG1388	LysM domain
L2Z21_RS07070	COG0741	lytic transglycosylase activity
L2Z21_RS07070	COG1388	LysM domain
L2Z21_RS07075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z21_RS07115	COG0583	DNA-binding transcription factor activity
L2Z21_RS07120	COG1279	arginine transmembrane transporter activity
L2Z21_RS07140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z21_RS07145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z21_RS07150	COG0006	proline dipeptidase activity
L2Z21_RS07200	COG4372	Transposase
L2Z21_RS07205	COG2194	sulfuric ester hydrolase activity
L2Z21_RS07255	COG0739	heme binding
L2Z21_RS07580	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2Z21_RS07605	COG3384	dioxygenase
L2Z21_RS07615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z21_RS07620	COG2878	Part of a membrane complex involved in electron transport
L2Z21_RS07625	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Z21_RS07650	COG0768	penicillin binding
L2Z21_RS07655	COG0742	ribosomal rna small subunit methyltransferase
L2Z21_RS07670	COG0830	nickel cation binding
L2Z21_RS07680	COG0804	urea catabolic process
L2Z21_RS07725	COG1253	flavin adenine dinucleotide binding
L2Z21_RS07730	COG2851	Citrate transporter
L2Z21_RS07780	COG1773	rubredoxin
L2Z21_RS07785	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z21_RS07795	COG0583	DNA-binding transcription factor activity
L2Z21_RS07820	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Z21_RS07825	COG4181	ATPase activity
L2Z21_RS07870	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z21_RS07890	COG0306	phosphate transporter
L2Z21_RS07900	COG3958	Transketolase
L2Z21_RS07905	COG3959	Transketolase, thiamine diphosphate binding domain
L2Z21_RS07910	COG2271	Major facilitator Superfamily
L2Z21_RS07915	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_RS07920	COG0583	DNA-binding transcription factor activity
L2Z21_RS07935	COG2223	nitrite transmembrane transporter activity
L2Z21_RS07940	COG2207	Transcriptional regulator
L2Z21_RS07945	COG2066	Belongs to the glutaminase family
L2Z21_RS07950	COG0242	peptide deformylase activity
L2Z21_RS07955	COG0477	Major facilitator Superfamily
L2Z21_RS07965	COG0028	Belongs to the TPP enzyme family
L2Z21_RS07980	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_RS07985	COG2267	carboxylic ester hydrolase activity
L2Z21_RS07995	COG2271	Major facilitator Superfamily
L2Z21_RS08000	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z21_RS08010	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_RS08030	COG1414	Transcriptional regulator
L2Z21_RS08045	COG1024	Enoyl-CoA hydratase
L2Z21_RS08055	COG1215	transferase activity, transferring glycosyl groups
L2Z21_RS08060	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z21_RS08060	COG0726	polysaccharide deacetylase
L2Z21_RS08070	COG4681	YaeQ
L2Z21_RS08080	COG0523	cobalamin synthesis protein
L2Z21_RS08090	COG1607	acyl-coa hydrolase
L2Z21_RS08100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z21_RS08105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z21_RS08110	COG1309	transcriptional regulator
L2Z21_RS08135	COG2040	homocysteine
L2Z21_RS08140	COG0531	amino acid
L2Z21_RS08195	COG1595	DNA-templated transcription, initiation
L2Z21_RS08205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z21_RS08210	COG0477	Major facilitator Superfamily
L2Z21_RS08230	COG0084	hydrolase, TatD family'
L2Z21_RS08280	COG0629	single-stranded DNA binding
L2Z21_RS08335	COG0582	viral genome integration into host DNA
L2Z21_RS08345	COG0405	Gamma-glutamyltransferase
L2Z21_RS08350	COG2814	Major facilitator Superfamily
L2Z21_RS08360	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z21_RS08375	COG1090	epimerase
L2Z21_RS08395	COG0420	3'-5' exonuclease activity
L2Z21_RS08420	COG0735	belongs to the Fur family
L2Z21_RS08425	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z21_RS08445	COG0121	glutamine amidotransferase
L2Z21_RS08460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z21_RS08470	COG0210	DNA helicase
L2Z21_RS08475	COG2885	chlorophyll binding
L2Z21_RS08480	COG0204	Acyl-transferase
L2Z21_RS08495	COG2894	cell division
L2Z21_RS08510	COG1280	lysine exporter protein (LysE YggA)
L2Z21_RS08515	COG1674	ftsk spoiiie
L2Z21_RS08515	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Z21_RS08520	COG0492	ferredoxin-NADP+ reductase activity
L2Z21_RS08525	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Z21_RS08535	COG0456	acetyltransferase
L2Z21_RS08580	COG1981	membrane
L2Z21_RS08595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z21_RS08595	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Z21_RS08615	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_RS08625	COG0657	acetylesterase activity
L2Z21_RS08635	COG0473	3-isopropylmalate dehydrogenase activity
L2Z21_RS08640	COG0583	DNA-binding transcription factor activity
L2Z21_RS08660	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z21_RS08685	COG0564	pseudouridine synthase activity
L2Z21_RS08695	COG0358	DNA primase activity
L2Z21_RS08710	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Z21_RS08740	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z21_RS08770	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2Z21_RS08780	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z21_RS08780	COG0352	thiamine-phosphate diphosphorylase activity
L2Z21_RS08780	COG0351	phosphomethylpyrimidine kinase
L2Z21_RS08785	COG1652	LysM domain
L2Z21_RS08810	COG1399	metal-binding, possibly nucleic acid-binding protein
L2Z21_RS08815	COG3101	peptidyl-lysine hydroxylation
L2Z21_RS08820	COG0009	L-threonylcarbamoyladenylate synthase
L2Z21_RS08825	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2Z21_RS08830	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Z21_RS08845	COG4106	trans-aconitate 2-methyltransferase activity
L2Z21_RS08860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z21_RS08860	COG0596	Alpha beta hydrolase
L2Z21_RS08860	COG2226	methyltransferase
L2Z21_RS08870	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2Z21_RS08875	COG2223	nitrite transmembrane transporter activity
L2Z21_RS08895	COG1196	nuclear chromosome segregation
L2Z21_RS08905	COG0730	response to heat
L2Z21_RS08920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Z21_RS08930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z21_RS08980	COG0489	protein tyrosine kinase activity
L2Z21_RS08990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z21_RS08990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z21_RS09020	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z21_RS09025	COG2081	HI0933 family
L2Z21_RS09035	COG0668	transmembrane transport
L2Z21_RS09055	COG0583	DNA-binding transcription factor activity
L2Z21_RS09080	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Z21_RS09085	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z21_RS09115	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Z21_RS09155	COG0745	RESPONSE REGULATOR receiver
L2Z21_RS09175	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Z21_RS09185	COG0384	phenazine biosynthesis protein PhzF
L2Z21_RS09205	COG2826	transposase and inactivated derivatives, IS30 family
L2Z21_RS09220	COG1309	transcriptional regulator
L2Z21_RS09225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z21_RS09240	COG0583	DNA-binding transcription factor activity
L2Z21_RS09270	COG0583	DNA-binding transcription factor activity
L2Z21_RS09285	COG0583	DNA-binding transcription factor activity
L2Z21_RS09290	COG1053	succinate dehydrogenase
L2Z21_RS09300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z21_RS09305	COG2814	Major facilitator Superfamily
L2Z21_RS09310	COG1960	acyl-CoA dehydrogenase activity
L2Z21_RS09315	COG0583	DNA-binding transcription factor activity
L2Z21_RS09320	COG1063	alcohol dehydrogenase
L2Z21_RS09350	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Z21_RS09355	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Z21_RS09360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z21_RS09375	COG3667	copper resistance
L2Z21_RS09380	COG2132	Multicopper oxidase
L2Z21_RS09390	COG0561	phosphatase activity
L2Z21_RS09395	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z21_RS09405	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
L2Z21_RS09420	COG1214	PFAM Peptidase M22, glycoprotease
L2Z21_RS09470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L2Z21_RS09480	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Z21_RS09485	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Z21_RS09490	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2Z21_RS09550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z21_RS09560	COG1846	Transcriptional regulator
L2Z21_RS09565	COG1764	response to oxidative stress
L2Z21_RS09605	COG0037	tRNA processing
L2Z21_RS09615	COG0248	Ppx GppA phosphatase
L2Z21_RS09645	COG0072	phenylalanine-tRNA ligase activity
L2Z21_RS09690	COG1238	metal cluster binding
L2Z21_RS09695	COG0625	glutathione transferase activity
L2Z21_RS09710	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z21_RS09715	COG3028	Belongs to the UPF0307 family
L2Z21_RS09720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z21_RS09740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Z21_RS09745	COG0617	tRNA 3'-terminal CCA addition
L2Z21_RS09750	COG1555	photosystem II stabilization
L2Z21_RS09755	COG3956	TIGRFAM MazG family protein
L2Z21_RS09765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z21_RS09785	COG0784	Response regulator, receiver
L2Z21_RS09785	COG2205	protein histidine kinase activity
L2Z21_RS09785	COG5002	protein histidine kinase activity
L2Z21_RS09790	COG1024	Enoyl-CoA hydratase
L2Z21_RS09795	COG2084	Dehydrogenase
L2Z21_RS09800	COG3622	Belongs to the hyi family
L2Z21_RS09830	COG0697	spore germination
L2Z21_RS09840	COG2814	Major facilitator Superfamily
L2Z21_RS09845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z21_RS09855	COG0583	DNA-binding transcription factor activity
L2Z21_RS09865	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Z21_RS09875	COG0084	hydrolase, TatD family'
L2Z21_RS09890	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Z21_RS09920	COG0440	acetolactate synthase activity
L2Z21_RS09925	COG0028	Belongs to the TPP enzyme family
L2Z21_RS09950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z21_RS09955	COG1136	(ABC) transporter
L2Z21_RS09955	COG0577	efflux transmembrane transporter activity
L2Z21_RS09960	COG1538	Outer membrane efflux protein
L2Z21_RS09975	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Z21_RS09980	COG1162	GTPase activity
L2Z21_RS09990	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2Z21_RS10030	COG1426	Protein conserved in bacteria
L2Z21_RS10065	COG0793	Belongs to the peptidase S41A family
L2Z21_RS10080	COG2267	carboxylic ester hydrolase activity
L2Z21_RS10090	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_RS10095	COG3265	gluconokinase activity
L2Z21_RS10105	COG0800	Aldolase
L2Z21_RS10115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Z21_RS10120	COG0280	phosphate acetyltransferase
L2Z21_RS10120	COG0857	belongs to the CobB CobQ family
L2Z21_RS10125	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z21_RS10125	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z21_RS10145	COG0740	serine-type endopeptidase activity
L2Z21_RS10155	COG4774	siderophore transport
L2Z21_RS10165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z21_RS10175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z21_RS10175	COG2813	Specifically methylates the guanine in position
L2Z21_RS10275	COG0788	formyltetrahydrofolate deformylase activity
L2Z21_RS10300	COG4651	solute:proton antiporter activity
L2Z21_RS10300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z21_RS10320	COG0724	RNA recognition motif
L2Z21_RS10325	COG0210	DNA helicase
L2Z21_RS10350	COG1733	regulation of RNA biosynthetic process
L2Z21_RS10360	COG2900	Belongs to the SlyX family
L2Z21_RS10365	COG0488	(ABC) transporter
L2Z21_RS10370	COG1280	lysine exporter protein (LysE YggA)
L2Z21_RS10375	COG1560	Kdo2-lipid A biosynthetic process
L2Z21_RS10385	COG1301	dicarboxylic acid transport
L2Z21_RS10440	COG0473	3-isopropylmalate dehydrogenase activity
L2Z21_RS10495	COG0583	DNA-binding transcription factor activity
L2Z21_RS10505	COG0625	glutathione transferase activity
L2Z21_RS10510	COG2378	regulation of single-species biofilm formation
L2Z21_RS10515	COG0546	phosphoglycolate phosphatase activity
L2Z21_RS10530	COG1530	ribonuclease E activity
L2Z21_RS10535	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z21_RS10550	COG0583	DNA-binding transcription factor activity
L2Z21_RS10555	COG4221	oxidoreductase activity
L2Z21_RS10560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z21_RS10570	COG0534	Mate efflux family protein
L2Z21_RS10585	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Z21_RS10610	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z21_RS10610	COG0493	'glutamate synthase
L2Z21_RS10620	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2Z21_RS10625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z21_RS10640	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z21_RS10650	COG0644	oxidoreductase
L2Z21_RS10650	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2Z21_RS10660	COG0425	Belongs to the sulfur carrier protein TusA family
L2Z21_RS10665	COG4535	Mg2 and Co2 transporter CorC
L2Z21_RS10675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z21_RS10695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Z21_RS10700	COG0475	glutathione-regulated potassium exporter activity
L2Z21_RS10700	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z21_RS10715	COG0484	heat shock protein binding
L2Z21_RS10720	COG0789	Transcriptional regulator
L2Z21_RS10725	COG0598	Magnesium transport protein CorA
L2Z21_RS10740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z21_RS10745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z21_RS10750	COG1074	ATP-dependent DNA helicase activity
L2Z21_RS10755	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Z21_RS10775	COG2226	methyltransferase
L2Z21_RS10790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z21_RS10795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Z21_RS10810	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z21_RS10810	COG2111	Na H antiporter
L2Z21_RS10815	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Z21_RS10820	COG0651	ATP synthesis coupled electron transport
L2Z21_RS10825	COG1863	multisubunit Na H antiporter MnhE subunit
L2Z21_RS10830	COG2212	antiporter activity
L2Z21_RS10835	COG1320	monovalent cation:proton antiporter activity
L2Z21_RS10850	COG0195	Participates in both transcription termination and antitermination
L2Z21_RS10900	COG0237	dephospho-CoA kinase activity
L2Z21_RS10910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z21_RS10925	COG0497	DNA recombination
L2Z21_RS10935	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Z21_RS10965	COG2169	Transcriptional regulator
L2Z21_RS10965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z21_RS10970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2Z21_RS11030	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2Z21_RS11045	COG0326	Molecular chaperone. Has ATPase activity
L2Z21_RS11060	COG2056	Na+-H+ antiporter family
L2Z21_RS11160	COG0546	phosphoglycolate phosphatase activity
L2Z21_RS11165	COG1716	ATPase activity
L2Z21_RS11210	COG0181	hydroxymethylbilane synthase activity
L2Z21_RS11220	COG3275	phosphorelay sensor kinase activity
L2Z21_RS11240	COG1538	Outer membrane efflux protein
L2Z21_RS11245	COG0697	spore germination
L2Z21_RS11270	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z21_RS11275	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Z21_RS11280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z21_RS11285	COG0772	Belongs to the SEDS family
L2Z21_RS11310	COG4974	Belongs to the 'phage' integrase family
L2Z21_RS11315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z21_RS11325	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2Z21_RS11335	COG2197	response regulator
L2Z21_RS11350	COG0793	Belongs to the peptidase S41A family
L2Z21_RS11355	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Z21_RS11360	COG0795	lipopolysaccharide-transporting ATPase activity
L2Z21_RS11400	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z21_RS11400	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z21_RS11430	COG0347	Belongs to the P(II) protein family
L2Z21_RS11520	COG0789	Transcriptional regulator
L2Z21_RS11545	COG0659	secondary active sulfate transmembrane transporter activity
L2Z21_RS11615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z21_RS11635	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Z21_RS11650	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z21_RS11660	COG0477	Major facilitator Superfamily
L2Z21_RS11665	COG2860	membrane
L2Z21_RS11670	COG3012	SEC-C Motif Domain Protein
L2Z21_RS11675	COG1253	flavin adenine dinucleotide binding
L2Z21_RS11685	COG0477	Major facilitator Superfamily
L2Z21_RS11695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z21_RS11735	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2Z21_RS11745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2Z21_RS11815	COG0758	DNA mediated transformation
L2Z21_RS11825	COG0697	spore germination
L2Z21_RS11830	COG1309	transcriptional regulator
L2Z21_RS11845	COG0386	Belongs to the glutathione peroxidase family
L2Z21_RS11910	COG1121	(ABC) transporter
L2Z21_RS11915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Z21_RS11920	COG1280	lysine exporter protein (LysE YggA)
L2Z21_RS11925	COG2837	iron assimilation
L2Z21_RS11930	COG0281	malic enzyme
L2Z21_RS11975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z21_RS11975	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z21_RS11980	COG4399	Belongs to the UPF0754 family
L2Z21_RS11985	COG2259	Doxx family
L2Z21_RS11990	COG0586	Pfam SNARE associated Golgi protein
L2Z21_RS12005	COG1192	Involved in chromosome partitioning
L2Z21_RS12015	COG0271	Belongs to the BolA IbaG family
L2Z21_RS12035	COG2267	carboxylic ester hydrolase activity
L2Z21_RS12055	COG3321	synthase
L2Z21_RS12055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Z21_RS12055	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
L2Z21_RS12055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z21_RS12060	COG1960	acyl-CoA dehydrogenase activity
L2Z21_RS12070	COG2197	response regulator
L2Z21_RS12080	COG3916	Acyl-homoserine-lactone synthase
L2Z21_RS12085	COG0477	Major facilitator Superfamily
L2Z21_RS12090	COG1024	Enoyl-CoA hydratase
L2Z21_RS12095	COG1024	Enoyl-CoA hydratase
L2Z21_RS12100	COG1960	acyl-CoA dehydrogenase activity
L2Z21_RS12105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z21_RS12125	COG1113	amino acid transport
L2Z21_RS12130	COG1113	amino acid transport
L2Z21_RS12135	COG0251	oxidation-reduction process
L2Z21_RS12175	COG0564	pseudouridine synthase activity
L2Z21_RS12225	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2Z21_RS12240	COG1802	Transcriptional regulator
L2Z21_RS12245	COG1448	Aminotransferase
L2Z21_RS12250	COG0277	FAD linked oxidase domain protein
L2Z21_RS12260	COG2186	Transcriptional regulator
L2Z21_RS12270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z21_RS12275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z21_RS12290	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Z21_RS12300	COG0110	maltose O-acetyltransferase activity
L2Z21_RS12305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L2Z21_RS12335	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z21_RS12340	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L2Z21_RS12345	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z21_RS12385	COG0728	peptidoglycan biosynthetic process
L2Z21_RS12390	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2Z21_RS12450	COG0546	phosphoglycolate phosphatase activity
L2Z21_RS12455	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_RS12475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z21_RS12480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z21_RS12485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z21_RS12490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z21_RS12495	COG1116	anion transmembrane transporter activity
L2Z21_RS12500	COG1309	transcriptional regulator
L2Z21_RS12505	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2Z21_RS12515	COG0196	riboflavin kinase activity
L2Z21_RS12520	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Z21_RS12530	COG1047	Peptidyl-prolyl cis-trans
L2Z21_RS12570	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2Z21_RS12575	COG0657	acetylesterase activity
L2Z21_RS12595	COG0583	DNA-binding transcription factor activity
L2Z21_RS12625	COG2951	lytic endotransglycosylase activity
L2Z21_RS12630	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Z21_RS12645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Z21_RS12655	COG0671	phosphoesterase, PA-phosphatase related
L2Z21_RS12660	COG0861	Integral membrane protein TerC family
L2Z21_RS12670	COG0754	glutathionylspermidine amidase activity
L2Z21_RS12680	COG0402	S-adenosylhomocysteine deaminase activity
L2Z21_RS12695	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z21_RS12700	COG1230	cation diffusion facilitator family transporter
L2Z21_RS12715	COG0706	membrane insertase activity
L2Z21_RS12740	COG0592	DNA-directed DNA polymerase activity
L2Z21_RS12750	COG0187	DNA topoisomerase II activity
L2Z21_RS12760	COG0586	Pfam SNARE associated Golgi protein
L2Z21_RS12765	COG0488	(ABC) transporter
L2Z21_RS12790	COG0596	Alpha beta hydrolase
L2Z21_RS12795	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2Z21_RS12800	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2Z21_RS12840	COG0733	neurotransmitter:sodium symporter activity
L2Z21_RS12875	COG0583	DNA-binding transcription factor activity
L2Z21_RS12880	COG2233	PERMEase
L2Z21_RS12895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z21_RS12930	COG2814	Major facilitator Superfamily
L2Z21_RS12935	COG0656	L-ascorbic acid biosynthetic process
L2Z21_RS12940	COG0583	DNA-binding transcription factor activity
L2Z21_RS12955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z21_RS12960	COG1064	alcohol dehydrogenase
L2Z21_RS12965	COG2818	Glycosylase
L2Z21_RS12980	COG1194	a g-specific adenine glycosylase
L2Z21_RS13000	COG2983	Belongs to the UPF0260 family
L2Z21_RS13005	COG2133	pyrroloquinoline quinone binding
L2Z21_RS13010	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Z21_RS13015	COG2116	formate transmembrane transporter activity
L2Z21_RS13035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z21_RS13040	COG1335	isochorismatase
L2Z21_RS13045	COG0385	Bile acid
L2Z21_RS13050	COG0534	Mate efflux family protein
L2Z21_RS13055	COG1683	Conserved Protein
L2Z21_RS13075	COG0625	glutathione transferase activity
L2Z21_RS13085	COG1113	amino acid transport
L2Z21_RS13095	COG0523	cobalamin synthesis protein
L2Z21_RS13105	COG2188	Transcriptional regulator
L2Z21_RS13135	COG0010	Belongs to the arginase family
L2Z21_RS13150	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z21_RS13160	COG2205	protein histidine kinase activity
L2Z21_RS13170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2Z21_RS13180	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Z21_RS13185	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2Z21_RS13270	COG0534	Mate efflux family protein
L2Z21_RS13275	COG0436	Aminotransferase
L2Z21_RS13280	COG2733	membrane
L2Z21_RS13295	COG2918	glutathione biosynthetic process
L2Z21_RS13345	COG3150	esterase
L2Z21_RS13355	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2Z21_RS13365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z21_RS13375	COG2233	PERMEase
L2Z21_RS13380	COG2351	hydroxyisourate hydrolase activity
L2Z21_RS13415	COG3706	GGDEF domain
L2Z21_RS13430	COG1393	Belongs to the ArsC family
L2Z21_RS13435	COG0708	Exodeoxyribonuclease III
L2Z21_RS13455	COG0189	ligase activity
L2Z21_RS13475	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Z21_RS13485	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Z21_RS13500	COG4942	peptidase
L2Z21_RS13510	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z21_RS13520	COG2119	membrane
L2Z21_RS13525	COG4774	siderophore transport
L2Z21_RS13530	COG0426	domain, Protein
L2Z21_RS13530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z21_RS13555	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2Z21_RS13575	COG1902	pentaerythritol trinitrate reductase activity
L2Z21_RS13580	COG1519	Transferase
L2Z21_RS13585	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z21_RS13590	COG0668	transmembrane transport
L2Z21_RS13600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z21_RS13605	COG1335	isochorismatase
L2Z21_RS13610	COG1522	sequence-specific DNA binding
L2Z21_RS13635	COG0784	Response regulator, receiver
L2Z21_RS13635	COG2198	Histidine kinase
L2Z21_RS13635	COG2205	protein histidine kinase activity
L2Z21_RS13640	COG3162	membrane
L2Z21_RS13645	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z21_RS13655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z21_RS13670	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2Z21_RS13675	COG1309	transcriptional regulator
L2Z21_RS13695	COG0351	phosphomethylpyrimidine kinase
L2Z21_RS13695	COG0352	thiamine-phosphate diphosphorylase activity
L2Z21_RS13695	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z21_RS13705	COG2814	Major facilitator Superfamily
L2Z21_RS13720	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z21_RS13730	COG1113	amino acid transport
L2Z21_RS13740	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z21_RS13745	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_RS13755	COG1335	isochorismatase
L2Z21_RS13785	COG2814	Major facilitator Superfamily
L2Z21_RS13790	COG0583	DNA-binding transcription factor activity
L2Z21_RS13810	COG0667	Aldo Keto reductase
L2Z21_RS13830	COG1733	regulation of RNA biosynthetic process
L2Z21_RS13845	COG1733	regulation of RNA biosynthetic process
L2Z21_RS13850	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z21_RS13860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L2Z21_RS13920	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Z21_RS13960	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Z21_RS13990	COG0427	acetyl-CoA hydrolase
L2Z21_RS14015	COG0659	secondary active sulfate transmembrane transporter activity
L2Z21_RS14020	COG4221	oxidoreductase activity
L2Z21_RS14025	COG2873	o-acetylhomoserine
L2Z21_RS14030	COG0488	(ABC) transporter
L2Z21_RS14095	COG0833	amino acid
L2Z21_RS14140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Z21_RS14145	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Z21_RS14160	COG2226	methyltransferase
L2Z21_RS14210	COG0070	glutamate synthase
L2Z21_RS14210	COG0067	glutamate synthase
L2Z21_RS14210	COG0069	glutamate synthase activity
L2Z21_RS14215	COG0493	'glutamate synthase
L2Z21_RS14225	COG1704	LemA family
L2Z21_RS14230	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2Z21_RS14245	COG3307	-O-antigen
L2Z21_RS14265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z21_RS14280	COG0194	GDP metabolic process
L2Z21_RS14330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Z21_RS14350	COG5380	lipid catabolic process
L2Z21_RS14355	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Z21_RS14380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Z21_RS14385	COG0277	FAD linked oxidase domain protein
L2Z21_RS14395	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2Z21_RS14400	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z21_RS14425	COG0628	permease
L2Z21_RS14430	COG1192	Involved in chromosome partitioning
L2Z21_RS14460	COG0833	amino acid
L2Z21_RS14465	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z21_RS14470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z21_RS14480	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_RS14520	COG0583	DNA-binding transcription factor activity
L2Z21_RS14570	COG0517	IMP dehydrogenase activity
L2Z21_RS14575	COG1983	PspC domain protein
L2Z21_RS14585	COG1960	acyl-CoA dehydrogenase activity
L2Z21_RS14600	COG0408	coproporphyrinogen oxidase activity
L2Z21_RS14620	COG0513	Belongs to the DEAD box helicase family
L2Z21_RS14630	COG1127	ABC transporter
L2Z21_RS14635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Z21_RS14645	COG2854	intermembrane phospholipid transfer
L2Z21_RS14655	COG0598	Magnesium transport protein CorA
L2Z21_RS14665	COG0494	nUDIX hydrolase
L2Z21_RS14670	COG1040	competence protein
L2Z21_RS14675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2Z21_RS14695	COG1946	Acyl-CoA thioesterase
L2Z21_RS14700	COG1301	dicarboxylic acid transport
L2Z21_RS14715	COG1959	2 iron, 2 sulfur cluster binding
L2Z21_RS14720	COG1017	nitric oxide dioxygenase activity
L2Z21_RS14720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z21_RS14725	COG0433	COG0433 Predicted ATPase
L2Z21_RS14730	COG0626	cystathionine gamma-synthase activity
L2Z21_RS14885	COG1960	acyl-CoA dehydrogenase activity
L2Z21_RS14890	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Z21_RS14920	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2Z21_RS14925	COG0339	signal peptide processing
L2Z21_RS14930	COG0557	exoribonuclease II activity
L2Z21_RS14975	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Z21_RS14980	COG2169	Transcriptional regulator
L2Z21_RS14985	COG0697	spore germination
L2Z21_RS14990	COG1295	ribonuclease BN
L2Z21_RS15025	COG1702	phosphate starvation-inducible protein PhoH
L2Z21_RS15035	COG0741	lytic transglycosylase activity
L2Z21_RS15035	COG0739	heme binding
L2Z21_RS15035	COG1196	nuclear chromosome segregation
L2Z21_RS15065	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Z21_RS15070	COG1183	phosphatidylcholine synthase activity
L2Z21_RS15115	COG1960	acyl-CoA dehydrogenase activity
L2Z21_RS15120	COG1309	transcriptional regulator
L2Z21_RS15135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z21_RS15140	COG1960	acyl-CoA dehydrogenase activity
L2Z21_RS15160	COG2969	positive regulation of protein catabolic process
L2Z21_RS15170	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Z21_RS15185	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Z21_RS15190	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z21_RS15210	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Z21_RS15220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z21_RS15225	COG1408	metallophosphoesterase
L2Z21_RS15235	COG2199	diguanylate cyclase activity
L2Z21_RS15295	COG1607	acyl-coa hydrolase
L2Z21_RS15325	COG2350	Protein conserved in bacteria
L2Z21_RS15335	COG0613	PHP domain protein
L2Z21_RS15340	COG3781	membrane
L2Z21_RS15350	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Z21_RS15365	COG1862	Preprotein translocase
L2Z21_RS15410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z21_RS15415	COG0629	single-stranded DNA binding
L2Z21_RS15460	COG3646	Phage regulatory protein
L2Z21_RS15470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L2Z21_RS15615	COG2205	protein histidine kinase activity
L2Z21_RS15620	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Z21_RS15640	COG0726	polysaccharide deacetylase
L2Z21_RS15645	COG0463	Glycosyl transferase, family 2
L2Z21_RS15650	COG0438	transferase activity, transferring glycosyl groups
L2Z21_RS15715	COG1960	acyl-CoA dehydrogenase activity
L2Z21_RS15720	COG1960	acyl-CoA dehydrogenase activity
L2Z21_RS15730	COG2205	protein histidine kinase activity
L2Z21_RS15735	COG0745	RESPONSE REGULATOR receiver
L2Z21_RS15740	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Z21_RS15760	COG2096	Adenosyltransferase
L2Z21_RS15810	COG0285	dihydrofolate synthase activity
L2Z21_RS15830	COG0450	alkyl hydroperoxide reductase
L2Z21_RS15845	COG0477	Major facilitator Superfamily
L2Z21_RS15850	COG1272	protein, Hemolysin III
L2Z21_RS15860	COG2153	protein acetylation
L2Z21_RS15880	COG0183	Belongs to the thiolase family
L2Z21_RS15885	COG2207	Transcriptional regulator
L2Z21_RS15905	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z21_RS15925	COG0183	Belongs to the thiolase family
L2Z21_RS15935	COG2885	chlorophyll binding
L2Z21_RS15935	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L2Z21_RS15945	COG1690	Belongs to the RtcB family
L2Z21_RS15950	COG0833	amino acid
L2Z21_RS15960	COG2233	PERMEase
L2Z21_RS15965	COG1217	gtp-binding protein TYPA
L2Z21_RS15990	COG2094	Belongs to the DNA glycosylase MPG family
L2Z21_RS15995	COG4772	TonB-dependent receptor
L2Z21_RS16000	COG1902	pentaerythritol trinitrate reductase activity
L2Z21_RS16015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z21_RS16020	COG0354	folic acid binding
L2Z21_RS16030	COG3189	MarR family transcriptional regulator
L2Z21_RS16035	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Z21_RS16040	COG3422	double-strand break repair
L2Z21_RS16080	COG0840	transmembrane signaling receptor activity
L2Z21_RS16110	COG5510	response to toxic substance
L2Z21_RS16120	COG2832	Protein of unknown function (DUF454)
L2Z21_RS16125	COG1376	ErfK ybiS ycfS ynhG family protein
L2Z21_RS16165	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Z21_RS16175	COG1289	transmembrane transporter activity
L2Z21_RS16180	COG2814	Major facilitator Superfamily
L2Z21_RS16200	COG1115	amino acid carrier protein
L2Z21_RS16205	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z21_RS16210	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z21_RS16215	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2Z21_RS16240	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z21_RS16250	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z21_RS16255	COG1077	Cell shape determining protein MreB Mrl
L2Z21_RS16260	COG1792	Involved in formation and maintenance of cell shape
L2Z21_RS16265	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2Z21_RS16270	COG0424	maF-like protein
L2Z21_RS16275	COG1530	ribonuclease E activity
L2Z21_RS16285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z21_RS16295	COG0560	Phosphoserine phosphatase
L2Z21_RS16305	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z21_RS16330	COG2207	Transcriptional regulator
L2Z21_RS16350	COG1113	amino acid transport
L2Z21_RS16355	COG2828	Protein conserved in bacteria
L2Z21_RS16360	COG0142	geranyltranstransferase activity
L2Z21_RS16365	COG2315	Protein conserved in bacteria
L2Z21_RS16380	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z21_RS16415	COG4372	Transposase
L2Z21_RS16425	COG0745	RESPONSE REGULATOR receiver
L2Z21_RS16430	COG0642	Histidine kinase
L2Z21_RS16440	COG0004	ammonium transporteR
L2Z21_RS16445	COG0583	DNA-binding transcription factor activity
L2Z21_RS16465	COG0525	valine-tRNA ligase activity
L2Z21_RS16475	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_RS16485	COG0393	Putative heavy-metal-binding
L2Z21_RS16490	COG0393	Putative heavy-metal-binding
L2Z21_RS16495	COG1538	Outer membrane efflux protein
L2Z21_RS16505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z21_RS16510	COG0671	phosphoesterase, PA-phosphatase related
L2Z21_RS16540	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Z21_RS16555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Z21_RS16555	COG1648	precorrin-2 dehydrogenase activity
L2Z21_RS16560	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Z21_RS16565	COG1733	regulation of RNA biosynthetic process
L2Z21_RS16575	COG0531	amino acid
L2Z21_RS16590	COG0321	lipoyl(octanoyl) transferase activity
L2Z21_RS16595	COG2921	Belongs to the UPF0250 family
L2Z21_RS16635	COG2009	succinate dehydrogenase
L2Z21_RS16640	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Z21_RS16645	COG1053	succinate dehydrogenase
L2Z21_RS16650	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Z21_RS16675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z21_RS16695	COG2354	Protein conserved in bacteria
L2Z21_RS16700	COG2321	neutral zinc metallopeptidase
L2Z21_RS16720	COG2843	Capsule synthesis protein
L2Z21_RS16735	COG0589	response to stress
L2Z21_RS16755	COG0505	Belongs to the CarA family
L2Z21_RS16780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z21_RS16785	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Z21_RS16835	COG0477	Major facilitator Superfamily
L2Z21_RS16840	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2Z21_RS16855	COG1597	lipid kinase activity
L2Z21_RS16860	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z21_RS16885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z21_RS16890	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z21_RS16910	COG0741	lytic transglycosylase activity
L2Z21_RS16930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z21_RS16945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z21_RS16980	COG0778	Nitroreductase
L2Z21_RS16995	COG1929	Belongs to the glycerate kinase type-1 family
L2Z21_RS17000	COG0243	molybdopterin cofactor binding
L2Z21_RS17005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2Z21_RS17010	COG3339	Conserved Protein
L2Z21_RS17020	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Z21_RS17040	COG1113	amino acid transport
L2Z21_RS17050	COG0019	diaminopimelate decarboxylase activity
L2Z21_RS17060	COG2267	carboxylic ester hydrolase activity
L2Z21_RS17065	COG1280	lysine exporter protein (LysE YggA)
L2Z21_RS17070	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z21_RS17120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z21_RS17155	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Z21_RS17160	COG1136	(ABC) transporter
L2Z21_RS17165	COG0658	competence protein
L2Z21_RS17165	COG2333	competence protein COMEC
L2Z21_RS17175	COG0616	signal peptide processing
L2Z21_RS17175	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Z21_RS17180	COG0596	Alpha beta hydrolase
L2Z21_RS17185	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Z21_RS17195	COG0628	permease
L2Z21_RS17230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z21_RS17250	COG0823	Involved in the tonB-independent uptake of proteins
L2Z21_RS17270	COG0824	Thioesterase
L2Z21_RS17275	COG1473	amidohydrolase
L2Z21_RS17295	COG0047	phosphoribosylformylglycinamidine synthase activity
L2Z21_RS17295	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2Z21_RS17300	COG2814	Major facilitator Superfamily
L2Z21_RS17315	COG1024	Enoyl-CoA hydratase
L2Z21_RS17320	COG1051	belongs to the nudix hydrolase family
L2Z21_RS17320	COG1056	cytidyltransferase-related domain
L2Z21_RS17330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Z21_RS17345	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2Z21_RS17360	COG4625	pathogenesis
L2Z21_RS17365	COG0583	DNA-binding transcription factor activity
L2Z21_RS17370	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2Z21_RS17375	COG4208	sulfate ABC transporter
L2Z21_RS17380	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2Z21_RS17390	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2Z21_RS17395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2Z21_RS17400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Z21_RS17420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z21_RS17435	COG0681	Belongs to the peptidase S26 family
L2Z21_RS17450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Z21_RS17460	COG1381	Involved in DNA repair and RecF pathway recombination
L2Z21_RS17465	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Z21_RS17475	COG4221	oxidoreductase activity
L2Z21_RS17505	COG0436	Aminotransferase
L2Z21_RS17525	COG0556	nucleotide-excision repair
L2Z21_RS17580	COG2070	2-Nitropropane dioxygenase
L2Z21_RS17610	COG1215	transferase activity, transferring glycosyl groups
L2Z21_RS17625	COG0415	Belongs to the DNA photolyase family
L2Z21_RS17635	COG1252	NADH dehydrogenase
L2Z21_RS17665	COG1187	pseudouridine synthase activity
L2Z21_RS17685	COG0477	Major facilitator Superfamily
L2Z21_RS17690	COG0583	DNA-binding transcription factor activity
L2Z21_RS17695	COG1823	symporter activity
L2Z21_RS17705	COG0612	Peptidase, M16
L2Z21_RS17730	COG0352	thiamine-phosphate diphosphorylase activity
L2Z21_RS17765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z21_RS17780	COG1309	transcriptional regulator
L2Z21_RS17790	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z21_RS17795	COG0076	glutamate decarboxylase activity
L2Z21_RS17805	COG1522	sequence-specific DNA binding
L2Z21_RS17810	COG3961	Belongs to the TPP enzyme family
L2Z21_RS17815	COG1113	amino acid transport
L2Z21_RS17820	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Z21_RS17825	COG0573	inorganic phosphate transmembrane transporter activity
L2Z21_RS17835	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Z21_RS17840	COG0616	signal peptide processing
L2Z21_RS17875	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Z21_RS17880	COG1686	Belongs to the peptidase S11 family
L2Z21_RS17905	COG0583	DNA-binding transcription factor activity
L2Z21_RS17910	COG1067	ATP-dependent peptidase activity
L2Z21_RS17955	COG1966	Carbon starvation protein
L2Z21_RS17960	COG2879	small protein
L2Z21_RS17995	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L2Z21_RS17995	COG2508	Transcriptional regulator
L2Z21_RS18025	COG4372	Transposase
L2Z21_RS18035	COG1113	amino acid transport
L2Z21_RS18040	COG0583	DNA-binding transcription factor activity
L2Z21_RS18045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z21_RS18050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z21_RS18060	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_RS18070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z21_RS18075	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2Z21_RS18075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z21_RS18110	COG2814	Major facilitator Superfamily
L2Z21_RS18115	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z21_RS18125	COG1309	transcriptional regulator
L2Z21_RS18145	COG1741	Belongs to the pirin family
L2Z21_RS18155	COG2964	Protein conserved in bacteria
L2Z21_RS18170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z21_RS18175	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z21_RS18180	COG4605	iron ion homeostasis
L2Z21_RS18185	COG4604	ABC transporter, ATP-binding protein
L2Z21_RS18190	COG4607	ABC-type enterochelin transport system periplasmic component
L2Z21_RS18195	COG4774	siderophore transport
L2Z21_RS18205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z21_RS18210	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z21_RS18215	COG3433	isochorismatase activity
L2Z21_RS18215	COG1535	isochorismatase
L2Z21_RS18230	COG1132	(ABC) transporter
L2Z21_RS18235	COG1132	(ABC) transporter
L2Z21_RS18240	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z21_RS18250	COG1169	isochorismate synthase
L2Z21_RS18265	COG3739	integral membrane protein
L2Z21_RS18295	COG3293	Transposase