locus-tag	class	description
L2Z23_RS00045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z23_RS00055	COG1846	Transcriptional regulator
L2Z23_RS00060	COG1764	response to oxidative stress
L2Z23_RS00110	COG0037	tRNA processing
L2Z23_RS00120	COG0248	Ppx GppA phosphatase
L2Z23_RS00150	COG0072	phenylalanine-tRNA ligase activity
L2Z23_RS00195	COG1238	metal cluster binding
L2Z23_RS00200	COG0625	glutathione transferase activity
L2Z23_RS00215	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z23_RS00220	COG3028	Belongs to the UPF0307 family
L2Z23_RS00225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z23_RS00245	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Z23_RS00250	COG0617	tRNA 3'-terminal CCA addition
L2Z23_RS00255	COG1555	photosystem II stabilization
L2Z23_RS00260	COG3956	TIGRFAM MazG family protein
L2Z23_RS00270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z23_RS00290	COG0784	Response regulator, receiver
L2Z23_RS00290	COG2205	protein histidine kinase activity
L2Z23_RS00290	COG5002	protein histidine kinase activity
L2Z23_RS00295	COG1024	Enoyl-CoA hydratase
L2Z23_RS00300	COG2084	Dehydrogenase
L2Z23_RS00305	COG3622	Belongs to the hyi family
L2Z23_RS00335	COG0697	spore germination
L2Z23_RS00345	COG2814	Major facilitator Superfamily
L2Z23_RS00350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z23_RS00360	COG0583	DNA-binding transcription factor activity
L2Z23_RS00370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Z23_RS00385	COG0084	hydrolase, TatD family'
L2Z23_RS00400	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Z23_RS00430	COG0440	acetolactate synthase activity
L2Z23_RS00435	COG0028	Belongs to the TPP enzyme family
L2Z23_RS00460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z23_RS00465	COG0577	efflux transmembrane transporter activity
L2Z23_RS00465	COG1136	(ABC) transporter
L2Z23_RS00470	COG1538	Outer membrane efflux protein
L2Z23_RS00485	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Z23_RS00490	COG1162	GTPase activity
L2Z23_RS00500	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2Z23_RS00520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L2Z23_RS00525	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z23_RS00565	COG2986	histidine ammonia-lyase
L2Z23_RS00580	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z23_RS00590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z23_RS00635	COG1426	Protein conserved in bacteria
L2Z23_RS00670	COG0793	Belongs to the peptidase S41A family
L2Z23_RS00685	COG2267	carboxylic ester hydrolase activity
L2Z23_RS00695	COG1012	belongs to the aldehyde dehydrogenase family
L2Z23_RS00700	COG3265	gluconokinase activity
L2Z23_RS00710	COG0800	Aldolase
L2Z23_RS00725	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Z23_RS00730	COG0280	phosphate acetyltransferase
L2Z23_RS00730	COG0857	belongs to the CobB CobQ family
L2Z23_RS00735	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z23_RS00735	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z23_RS00755	COG0740	serine-type endopeptidase activity
L2Z23_RS00765	COG4774	siderophore transport
L2Z23_RS00775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z23_RS00785	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z23_RS00785	COG2813	Specifically methylates the guanine in position
L2Z23_RS00885	COG0788	formyltetrahydrofolate deformylase activity
L2Z23_RS00910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z23_RS00910	COG4651	solute:proton antiporter activity
L2Z23_RS00930	COG0724	RNA recognition motif
L2Z23_RS00935	COG0210	DNA helicase
L2Z23_RS00960	COG1733	regulation of RNA biosynthetic process
L2Z23_RS00970	COG2900	Belongs to the SlyX family
L2Z23_RS00975	COG0488	(ABC) transporter
L2Z23_RS00980	COG1280	lysine exporter protein (LysE YggA)
L2Z23_RS00985	COG1560	Kdo2-lipid A biosynthetic process
L2Z23_RS00995	COG1301	dicarboxylic acid transport
L2Z23_RS01050	COG0473	3-isopropylmalate dehydrogenase activity
L2Z23_RS01115	COG0583	DNA-binding transcription factor activity
L2Z23_RS01125	COG0625	glutathione transferase activity
L2Z23_RS01130	COG2378	regulation of single-species biofilm formation
L2Z23_RS01135	COG0546	phosphoglycolate phosphatase activity
L2Z23_RS01145	COG1530	ribonuclease E activity
L2Z23_RS01150	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z23_RS01165	COG0583	DNA-binding transcription factor activity
L2Z23_RS01170	COG4221	oxidoreductase activity
L2Z23_RS01175	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z23_RS01185	COG0534	Mate efflux family protein
L2Z23_RS01200	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Z23_RS01240	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2Z23_RS01245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z23_RS01260	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z23_RS01270	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2Z23_RS01270	COG0644	oxidoreductase
L2Z23_RS01275	COG0425	Belongs to the sulfur carrier protein TusA family
L2Z23_RS01280	COG4535	Mg2 and Co2 transporter CorC
L2Z23_RS01290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z23_RS01310	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Z23_RS01315	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z23_RS01315	COG0475	glutathione-regulated potassium exporter activity
L2Z23_RS01320	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L2Z23_RS01330	COG0484	heat shock protein binding
L2Z23_RS01335	COG0789	Transcriptional regulator
L2Z23_RS01340	COG0598	Magnesium transport protein CorA
L2Z23_RS01355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z23_RS01360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z23_RS01365	COG1074	ATP-dependent DNA helicase activity
L2Z23_RS01370	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Z23_RS01390	COG2226	methyltransferase
L2Z23_RS01405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z23_RS01410	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Z23_RS01425	COG2111	Na H antiporter
L2Z23_RS01425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z23_RS01430	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Z23_RS01435	COG0651	ATP synthesis coupled electron transport
L2Z23_RS01440	COG1863	multisubunit Na H antiporter MnhE subunit
L2Z23_RS01445	COG2212	antiporter activity
L2Z23_RS01450	COG1320	monovalent cation:proton antiporter activity
L2Z23_RS01465	COG0195	Participates in both transcription termination and antitermination
L2Z23_RS01515	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L2Z23_RS01520	COG0237	dephospho-CoA kinase activity
L2Z23_RS01530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z23_RS01545	COG0497	DNA recombination
L2Z23_RS01555	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Z23_RS01585	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z23_RS01585	COG2169	Transcriptional regulator
L2Z23_RS01590	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2Z23_RS01655	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2Z23_RS01670	COG0326	Molecular chaperone. Has ATPase activity
L2Z23_RS01685	COG2056	Na+-H+ antiporter family
L2Z23_RS01690	COG0596	Alpha beta hydrolase
L2Z23_RS01785	COG0546	phosphoglycolate phosphatase activity
L2Z23_RS01790	COG1716	ATPase activity
L2Z23_RS01835	COG0181	hydroxymethylbilane synthase activity
L2Z23_RS01845	COG3275	phosphorelay sensor kinase activity
L2Z23_RS01865	COG1538	Outer membrane efflux protein
L2Z23_RS01870	COG0697	spore germination
L2Z23_RS01895	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z23_RS01900	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Z23_RS01905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z23_RS01910	COG0772	Belongs to the SEDS family
L2Z23_RS01935	COG4974	Belongs to the 'phage' integrase family
L2Z23_RS01940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z23_RS01950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2Z23_RS01960	COG2197	response regulator
L2Z23_RS01975	COG0793	Belongs to the peptidase S41A family
L2Z23_RS01980	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Z23_RS01985	COG0795	lipopolysaccharide-transporting ATPase activity
L2Z23_RS02025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z23_RS02025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z23_RS02035	COG0004	ammonium transporteR
L2Z23_RS02040	COG0347	Belongs to the P(II) protein family
L2Z23_RS02115	COG1061	Type III restriction enzyme res subunit
L2Z23_RS02120	COG1002	Type II restriction enzyme, methylase subunits
L2Z23_RS02130	COG0659	secondary active sulfate transmembrane transporter activity
L2Z23_RS02135	COG0589	response to stress
L2Z23_RS02180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z23_RS02200	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Z23_RS02215	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z23_RS02225	COG0477	Major facilitator Superfamily
L2Z23_RS02230	COG2860	membrane
L2Z23_RS02240	COG1253	flavin adenine dinucleotide binding
L2Z23_RS02260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z23_RS02300	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2Z23_RS02310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2Z23_RS02380	COG0758	DNA mediated transformation
L2Z23_RS02390	COG0697	spore germination
L2Z23_RS02395	COG1309	transcriptional regulator
L2Z23_RS02410	COG0386	Belongs to the glutathione peroxidase family
L2Z23_RS02475	COG1121	(ABC) transporter
L2Z23_RS02480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Z23_RS02485	COG1280	lysine exporter protein (LysE YggA)
L2Z23_RS02490	COG2837	iron assimilation
L2Z23_RS02500	COG0281	malic enzyme
L2Z23_RS02545	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z23_RS02545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z23_RS02550	COG4399	Belongs to the UPF0754 family
L2Z23_RS02555	COG2259	Doxx family
L2Z23_RS02560	COG0586	Pfam SNARE associated Golgi protein
L2Z23_RS02575	COG1192	Involved in chromosome partitioning
L2Z23_RS02585	COG0271	Belongs to the BolA IbaG family
L2Z23_RS02605	COG2267	carboxylic ester hydrolase activity
L2Z23_RS02625	COG3321	synthase
L2Z23_RS02625	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
L2Z23_RS02625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Z23_RS02625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z23_RS02630	COG1960	acyl-CoA dehydrogenase activity
L2Z23_RS02640	COG2197	response regulator
L2Z23_RS02650	COG3916	Acyl-homoserine-lactone synthase
L2Z23_RS02655	COG0477	Major facilitator Superfamily
L2Z23_RS02660	COG1024	Enoyl-CoA hydratase
L2Z23_RS02665	COG1024	Enoyl-CoA hydratase
L2Z23_RS02670	COG1960	acyl-CoA dehydrogenase activity
L2Z23_RS02675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z23_RS02695	COG1113	amino acid transport
L2Z23_RS02700	COG1113	amino acid transport
L2Z23_RS02705	COG0251	oxidation-reduction process
L2Z23_RS02745	COG0564	pseudouridine synthase activity
L2Z23_RS02805	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2Z23_RS02820	COG1802	Transcriptional regulator
L2Z23_RS02825	COG1448	Aminotransferase
L2Z23_RS02830	COG0277	FAD linked oxidase domain protein
L2Z23_RS02840	COG2186	Transcriptional regulator
L2Z23_RS02850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z23_RS02855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z23_RS02870	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Z23_RS02880	COG0110	maltose O-acetyltransferase activity
L2Z23_RS02885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L2Z23_RS02915	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z23_RS02920	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L2Z23_RS02925	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z23_RS02965	COG0728	peptidoglycan biosynthetic process
L2Z23_RS02970	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2Z23_RS03025	COG0546	phosphoglycolate phosphatase activity
L2Z23_RS03030	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z23_RS03050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z23_RS03055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z23_RS03060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z23_RS03065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z23_RS03070	COG1116	anion transmembrane transporter activity
L2Z23_RS03075	COG1309	transcriptional regulator
L2Z23_RS03080	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2Z23_RS03090	COG0196	riboflavin kinase activity
L2Z23_RS03095	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Z23_RS03105	COG1047	Peptidyl-prolyl cis-trans
L2Z23_RS03145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2Z23_RS03150	COG0657	acetylesterase activity
L2Z23_RS03170	COG0583	DNA-binding transcription factor activity
L2Z23_RS03200	COG2951	lytic endotransglycosylase activity
L2Z23_RS03205	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Z23_RS03220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Z23_RS03230	COG0671	phosphoesterase, PA-phosphatase related
L2Z23_RS03235	COG0861	Integral membrane protein TerC family
L2Z23_RS03245	COG0754	glutathionylspermidine amidase activity
L2Z23_RS03255	COG0402	S-adenosylhomocysteine deaminase activity
L2Z23_RS03270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z23_RS03275	COG1230	cation diffusion facilitator family transporter
L2Z23_RS03290	COG0706	membrane insertase activity
L2Z23_RS03315	COG0592	DNA-directed DNA polymerase activity
L2Z23_RS03325	COG0187	DNA topoisomerase II activity
L2Z23_RS03335	COG0586	Pfam SNARE associated Golgi protein
L2Z23_RS03340	COG0488	(ABC) transporter
L2Z23_RS03365	COG0596	Alpha beta hydrolase
L2Z23_RS03370	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2Z23_RS03375	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2Z23_RS03415	COG0733	neurotransmitter:sodium symporter activity
L2Z23_RS03455	COG2233	PERMEase
L2Z23_RS03470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z23_RS03505	COG2814	Major facilitator Superfamily
L2Z23_RS03510	COG0656	L-ascorbic acid biosynthetic process
L2Z23_RS03515	COG0583	DNA-binding transcription factor activity
L2Z23_RS03530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z23_RS03535	COG1064	alcohol dehydrogenase
L2Z23_RS03540	COG2818	Glycosylase
L2Z23_RS03555	COG1194	a g-specific adenine glycosylase
L2Z23_RS03575	COG2983	Belongs to the UPF0260 family
L2Z23_RS03580	COG2133	pyrroloquinoline quinone binding
L2Z23_RS03585	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Z23_RS03590	COG2116	formate transmembrane transporter activity
L2Z23_RS03610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z23_RS03615	COG1335	isochorismatase
L2Z23_RS03620	COG0385	Bile acid
L2Z23_RS03625	COG0534	Mate efflux family protein
L2Z23_RS03630	COG1683	Conserved Protein
L2Z23_RS03650	COG0625	glutathione transferase activity
L2Z23_RS03660	COG1113	amino acid transport
L2Z23_RS03670	COG0523	cobalamin synthesis protein
L2Z23_RS03680	COG2188	Transcriptional regulator
L2Z23_RS03710	COG0010	Belongs to the arginase family
L2Z23_RS03725	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z23_RS03730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2Z23_RS03740	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Z23_RS03745	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2Z23_RS03845	COG0534	Mate efflux family protein
L2Z23_RS03850	COG0436	Aminotransferase
L2Z23_RS03855	COG2733	membrane
L2Z23_RS03870	COG2918	glutathione biosynthetic process
L2Z23_RS03900	COG3150	esterase
L2Z23_RS03910	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z23_RS03915	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2Z23_RS03925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z23_RS03935	COG2233	PERMEase
L2Z23_RS03940	COG2351	hydroxyisourate hydrolase activity
L2Z23_RS03975	COG3706	GGDEF domain
L2Z23_RS03990	COG1393	Belongs to the ArsC family
L2Z23_RS03995	COG0708	Exodeoxyribonuclease III
L2Z23_RS04015	COG0189	ligase activity
L2Z23_RS04035	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Z23_RS04045	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Z23_RS04060	COG4942	peptidase
L2Z23_RS04070	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z23_RS04080	COG2119	membrane
L2Z23_RS04085	COG4774	siderophore transport
L2Z23_RS04090	COG0426	domain, Protein
L2Z23_RS04090	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z23_RS04115	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2Z23_RS04135	COG1902	pentaerythritol trinitrate reductase activity
L2Z23_RS04140	COG1519	Transferase
L2Z23_RS04145	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z23_RS04150	COG0668	transmembrane transport
L2Z23_RS04160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z23_RS04165	COG1335	isochorismatase
L2Z23_RS04170	COG1522	sequence-specific DNA binding
L2Z23_RS04175	COG3328	transposase activity
L2Z23_RS04200	COG0784	Response regulator, receiver
L2Z23_RS04200	COG2198	Histidine kinase
L2Z23_RS04200	COG2205	protein histidine kinase activity
L2Z23_RS04205	COG3162	membrane
L2Z23_RS04210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z23_RS04220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z23_RS04240	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2Z23_RS04245	COG1309	transcriptional regulator
L2Z23_RS04265	COG0351	phosphomethylpyrimidine kinase
L2Z23_RS04265	COG0352	thiamine-phosphate diphosphorylase activity
L2Z23_RS04265	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z23_RS04275	COG2814	Major facilitator Superfamily
L2Z23_RS04290	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z23_RS04300	COG1113	amino acid transport
L2Z23_RS04310	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z23_RS04315	COG1012	belongs to the aldehyde dehydrogenase family
L2Z23_RS04325	COG1335	isochorismatase
L2Z23_RS04355	COG2814	Major facilitator Superfamily
L2Z23_RS04360	COG0583	DNA-binding transcription factor activity
L2Z23_RS04380	COG0667	Aldo Keto reductase
L2Z23_RS04415	COG1733	regulation of RNA biosynthetic process
L2Z23_RS04420	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z23_RS04485	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Z23_RS04500	COG2329	Antibiotic biosynthesis monooxygenase
L2Z23_RS04530	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Z23_RS04560	COG0427	acetyl-CoA hydrolase
L2Z23_RS04585	COG0659	secondary active sulfate transmembrane transporter activity
L2Z23_RS04590	COG4221	oxidoreductase activity
L2Z23_RS04595	COG2873	o-acetylhomoserine
L2Z23_RS04600	COG0488	(ABC) transporter
L2Z23_RS04685	COG0833	amino acid
L2Z23_RS04730	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Z23_RS04735	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Z23_RS04750	COG2226	methyltransferase
L2Z23_RS04800	COG0067	glutamate synthase
L2Z23_RS04800	COG0069	glutamate synthase activity
L2Z23_RS04800	COG0070	glutamate synthase
L2Z23_RS04805	COG0493	'glutamate synthase
L2Z23_RS04815	COG1704	LemA family
L2Z23_RS04820	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2Z23_RS04840	COG3307	-O-antigen
L2Z23_RS04860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z23_RS04875	COG0194	GDP metabolic process
L2Z23_RS04925	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Z23_RS04945	COG5380	lipid catabolic process
L2Z23_RS04950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Z23_RS04975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Z23_RS04980	COG0277	FAD linked oxidase domain protein
L2Z23_RS04990	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2Z23_RS04995	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z23_RS05010	COG1289	transmembrane transporter activity
L2Z23_RS05020	COG0628	permease
L2Z23_RS05025	COG1192	Involved in chromosome partitioning
L2Z23_RS05055	COG0833	amino acid
L2Z23_RS05060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z23_RS05075	COG1012	belongs to the aldehyde dehydrogenase family
L2Z23_RS05115	COG0583	DNA-binding transcription factor activity
L2Z23_RS05160	COG0517	IMP dehydrogenase activity
L2Z23_RS05165	COG1983	PspC domain protein
L2Z23_RS05175	COG1960	acyl-CoA dehydrogenase activity
L2Z23_RS05190	COG0408	coproporphyrinogen oxidase activity
L2Z23_RS05210	COG0513	Belongs to the DEAD box helicase family
L2Z23_RS05220	COG1127	ABC transporter
L2Z23_RS05225	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Z23_RS05235	COG2854	intermembrane phospholipid transfer
L2Z23_RS05245	COG0598	Magnesium transport protein CorA
L2Z23_RS05255	COG0494	nUDIX hydrolase
L2Z23_RS05260	COG1040	competence protein
L2Z23_RS05265	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2Z23_RS05285	COG1946	Acyl-CoA thioesterase
L2Z23_RS05290	COG1301	dicarboxylic acid transport
L2Z23_RS05305	COG1959	2 iron, 2 sulfur cluster binding
L2Z23_RS05310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z23_RS05310	COG1017	nitric oxide dioxygenase activity
L2Z23_RS05315	COG0433	COG0433 Predicted ATPase
L2Z23_RS05320	COG0626	cystathionine gamma-synthase activity
L2Z23_RS05475	COG1960	acyl-CoA dehydrogenase activity
L2Z23_RS05480	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Z23_RS05510	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2Z23_RS05515	COG0339	signal peptide processing
L2Z23_RS05520	COG0557	exoribonuclease II activity
L2Z23_RS05565	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Z23_RS05570	COG2169	Transcriptional regulator
L2Z23_RS05575	COG0697	spore germination
L2Z23_RS05580	COG1295	ribonuclease BN
L2Z23_RS05615	COG1702	phosphate starvation-inducible protein PhoH
L2Z23_RS05625	COG1196	nuclear chromosome segregation
L2Z23_RS05625	COG0739	heme binding
L2Z23_RS05625	COG0741	lytic transglycosylase activity
L2Z23_RS05655	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Z23_RS05660	COG1183	phosphatidylcholine synthase activity
L2Z23_RS05705	COG1960	acyl-CoA dehydrogenase activity
L2Z23_RS05710	COG1309	transcriptional regulator
L2Z23_RS05725	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z23_RS05730	COG1960	acyl-CoA dehydrogenase activity
L2Z23_RS05750	COG2969	positive regulation of protein catabolic process
L2Z23_RS05760	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Z23_RS05775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Z23_RS05780	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z23_RS05800	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Z23_RS05810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z23_RS05815	COG1408	metallophosphoesterase
L2Z23_RS05825	COG2199	diguanylate cyclase activity
L2Z23_RS05895	COG1607	acyl-coa hydrolase
L2Z23_RS05925	COG2350	Protein conserved in bacteria
L2Z23_RS05935	COG0613	PHP domain protein
L2Z23_RS05940	COG3781	membrane
L2Z23_RS05950	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Z23_RS05955	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2Z23_RS05965	COG1862	Preprotein translocase
L2Z23_RS05995	COG2205	protein histidine kinase activity
L2Z23_RS06000	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Z23_RS06020	COG0726	polysaccharide deacetylase
L2Z23_RS06025	COG0463	Glycosyl transferase, family 2
L2Z23_RS06030	COG0438	transferase activity, transferring glycosyl groups
L2Z23_RS06095	COG0625	glutathione transferase activity
L2Z23_RS06100	COG0583	DNA-binding transcription factor activity
L2Z23_RS06105	COG1960	acyl-CoA dehydrogenase activity
L2Z23_RS06110	COG1960	acyl-CoA dehydrogenase activity
L2Z23_RS06120	COG2205	protein histidine kinase activity
L2Z23_RS06125	COG0745	RESPONSE REGULATOR receiver
L2Z23_RS06130	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Z23_RS06150	COG2096	Adenosyltransferase
L2Z23_RS06205	COG0285	dihydrofolate synthase activity
L2Z23_RS06225	COG0450	alkyl hydroperoxide reductase
L2Z23_RS06240	COG0477	Major facilitator Superfamily
L2Z23_RS06245	COG1272	protein, Hemolysin III
L2Z23_RS06275	COG0183	Belongs to the thiolase family
L2Z23_RS06280	COG2207	Transcriptional regulator
L2Z23_RS06300	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z23_RS06320	COG0183	Belongs to the thiolase family
L2Z23_RS06330	COG2885	chlorophyll binding
L2Z23_RS06330	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L2Z23_RS06340	COG1690	Belongs to the RtcB family
L2Z23_RS06345	COG0833	amino acid
L2Z23_RS06355	COG2233	PERMEase
L2Z23_RS06360	COG1217	gtp-binding protein TYPA
L2Z23_RS06385	COG2094	Belongs to the DNA glycosylase MPG family
L2Z23_RS06405	COG1902	pentaerythritol trinitrate reductase activity
L2Z23_RS06420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z23_RS06425	COG0354	folic acid binding
L2Z23_RS06435	COG3189	MarR family transcriptional regulator
L2Z23_RS06440	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Z23_RS06445	COG3422	double-strand break repair
L2Z23_RS06485	COG0840	transmembrane signaling receptor activity
L2Z23_RS06505	COG5510	response to toxic substance
L2Z23_RS06515	COG2832	Protein of unknown function (DUF454)
L2Z23_RS06520	COG1376	ErfK ybiS ycfS ynhG family protein
L2Z23_RS06560	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Z23_RS06570	COG1289	transmembrane transporter activity
L2Z23_RS06575	COG2814	Major facilitator Superfamily
L2Z23_RS06595	COG1115	amino acid carrier protein
L2Z23_RS06600	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z23_RS06605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z23_RS06610	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2Z23_RS06650	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z23_RS06660	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z23_RS06665	COG1077	Cell shape determining protein MreB Mrl
L2Z23_RS06670	COG1792	Involved in formation and maintenance of cell shape
L2Z23_RS06675	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2Z23_RS06680	COG0424	maF-like protein
L2Z23_RS06685	COG1530	ribonuclease E activity
L2Z23_RS06695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z23_RS06705	COG0560	Phosphoserine phosphatase
L2Z23_RS06715	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z23_RS06740	COG2207	Transcriptional regulator
L2Z23_RS06760	COG1113	amino acid transport
L2Z23_RS06765	COG2828	Protein conserved in bacteria
L2Z23_RS06770	COG0142	geranyltranstransferase activity
L2Z23_RS06775	COG2315	Protein conserved in bacteria
L2Z23_RS06790	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z23_RS06810	COG2194	sulfuric ester hydrolase activity
L2Z23_RS06815	COG0745	RESPONSE REGULATOR receiver
L2Z23_RS06820	COG0642	Histidine kinase
L2Z23_RS06830	COG0004	ammonium transporteR
L2Z23_RS06835	COG0583	DNA-binding transcription factor activity
L2Z23_RS06855	COG0525	valine-tRNA ligase activity
L2Z23_RS06865	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z23_RS06875	COG0393	Putative heavy-metal-binding
L2Z23_RS06880	COG0393	Putative heavy-metal-binding
L2Z23_RS06885	COG1538	Outer membrane efflux protein
L2Z23_RS06895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z23_RS06900	COG0671	phosphoesterase, PA-phosphatase related
L2Z23_RS06930	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Z23_RS06945	COG1648	precorrin-2 dehydrogenase activity
L2Z23_RS06945	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Z23_RS06950	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Z23_RS06955	COG1733	regulation of RNA biosynthetic process
L2Z23_RS06965	COG0531	amino acid
L2Z23_RS06980	COG0321	lipoyl(octanoyl) transferase activity
L2Z23_RS06985	COG2921	Belongs to the UPF0250 family
L2Z23_RS07025	COG2009	succinate dehydrogenase
L2Z23_RS07030	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Z23_RS07035	COG1053	succinate dehydrogenase
L2Z23_RS07040	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Z23_RS07065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z23_RS07085	COG2354	Protein conserved in bacteria
L2Z23_RS07090	COG2321	neutral zinc metallopeptidase
L2Z23_RS07110	COG2843	Capsule synthesis protein
L2Z23_RS07125	COG0589	response to stress
L2Z23_RS07145	COG0505	Belongs to the CarA family
L2Z23_RS07170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z23_RS07175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Z23_RS07225	COG0477	Major facilitator Superfamily
L2Z23_RS07230	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2Z23_RS07245	COG1597	lipid kinase activity
L2Z23_RS07250	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z23_RS07280	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z23_RS07300	COG0741	lytic transglycosylase activity
L2Z23_RS07320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z23_RS07335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z23_RS07370	COG0778	Nitroreductase
L2Z23_RS07385	COG1929	Belongs to the glycerate kinase type-1 family
L2Z23_RS07390	COG0243	molybdopterin cofactor binding
L2Z23_RS07395	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2Z23_RS07400	COG3339	Conserved Protein
L2Z23_RS07410	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Z23_RS07425	COG1113	amino acid transport
L2Z23_RS07435	COG0019	diaminopimelate decarboxylase activity
L2Z23_RS07445	COG1280	lysine exporter protein (LysE YggA)
L2Z23_RS07450	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z23_RS07480	COG0463	Glycosyl transferase, family 2
L2Z23_RS07500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z23_RS07535	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Z23_RS07540	COG1136	(ABC) transporter
L2Z23_RS07545	COG2333	competence protein COMEC
L2Z23_RS07545	COG0658	competence protein
L2Z23_RS07555	COG0616	signal peptide processing
L2Z23_RS07555	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Z23_RS07560	COG0596	Alpha beta hydrolase
L2Z23_RS07565	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Z23_RS07575	COG0628	permease
L2Z23_RS07610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z23_RS07630	COG0823	Involved in the tonB-independent uptake of proteins
L2Z23_RS07650	COG0824	Thioesterase
L2Z23_RS07655	COG1473	amidohydrolase
L2Z23_RS07675	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2Z23_RS07675	COG0047	phosphoribosylformylglycinamidine synthase activity
L2Z23_RS07680	COG2814	Major facilitator Superfamily
L2Z23_RS07690	COG1024	Enoyl-CoA hydratase
L2Z23_RS07695	COG1056	cytidyltransferase-related domain
L2Z23_RS07695	COG1051	belongs to the nudix hydrolase family
L2Z23_RS07705	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Z23_RS07720	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2Z23_RS07735	COG4625	pathogenesis
L2Z23_RS07740	COG0583	DNA-binding transcription factor activity
L2Z23_RS07745	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2Z23_RS07750	COG4208	sulfate ABC transporter
L2Z23_RS07755	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2Z23_RS07765	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2Z23_RS07770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2Z23_RS07775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Z23_RS07795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z23_RS07810	COG0681	Belongs to the peptidase S26 family
L2Z23_RS07825	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Z23_RS07835	COG1381	Involved in DNA repair and RecF pathway recombination
L2Z23_RS07840	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Z23_RS07850	COG4221	oxidoreductase activity
L2Z23_RS07880	COG0436	Aminotransferase
L2Z23_RS07900	COG0556	nucleotide-excision repair
L2Z23_RS07955	COG2070	2-Nitropropane dioxygenase
L2Z23_RS07985	COG1215	transferase activity, transferring glycosyl groups
L2Z23_RS08000	COG0415	Belongs to the DNA photolyase family
L2Z23_RS08010	COG1252	NADH dehydrogenase
L2Z23_RS08015	COG1686	Belongs to the peptidase S11 family
L2Z23_RS08030	COG1187	pseudouridine synthase activity
L2Z23_RS08055	COG0477	Major facilitator Superfamily
L2Z23_RS08060	COG0583	DNA-binding transcription factor activity
L2Z23_RS08065	COG1823	symporter activity
L2Z23_RS08075	COG0612	Peptidase, M16
L2Z23_RS08100	COG0352	thiamine-phosphate diphosphorylase activity
L2Z23_RS08135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z23_RS08150	COG1309	transcriptional regulator
L2Z23_RS08160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z23_RS08165	COG0076	glutamate decarboxylase activity
L2Z23_RS08175	COG1522	sequence-specific DNA binding
L2Z23_RS08180	COG3961	Belongs to the TPP enzyme family
L2Z23_RS08185	COG1113	amino acid transport
L2Z23_RS08190	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Z23_RS08195	COG0573	inorganic phosphate transmembrane transporter activity
L2Z23_RS08205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Z23_RS08210	COG0616	signal peptide processing
L2Z23_RS08220	COG3328	transposase activity
L2Z23_RS08250	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Z23_RS08255	COG1686	Belongs to the peptidase S11 family
L2Z23_RS08280	COG0583	DNA-binding transcription factor activity
L2Z23_RS08285	COG1067	ATP-dependent peptidase activity
L2Z23_RS08330	COG1966	Carbon starvation protein
L2Z23_RS08335	COG2879	small protein
L2Z23_RS08370	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L2Z23_RS08370	COG2508	Transcriptional regulator
L2Z23_RS08390	COG1113	amino acid transport
L2Z23_RS08395	COG0583	DNA-binding transcription factor activity
L2Z23_RS08400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z23_RS08405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z23_RS08415	COG1012	belongs to the aldehyde dehydrogenase family
L2Z23_RS08425	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z23_RS08430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z23_RS08430	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2Z23_RS08465	COG2814	Major facilitator Superfamily
L2Z23_RS08470	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z23_RS08480	COG1309	transcriptional regulator
L2Z23_RS08500	COG1741	Belongs to the pirin family
L2Z23_RS08510	COG2964	Protein conserved in bacteria
L2Z23_RS08525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z23_RS08530	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z23_RS08535	COG4605	iron ion homeostasis
L2Z23_RS08540	COG4604	ABC transporter, ATP-binding protein
L2Z23_RS08545	COG4607	ABC-type enterochelin transport system periplasmic component
L2Z23_RS08550	COG4774	siderophore transport
L2Z23_RS08560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z23_RS08565	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z23_RS08570	COG3433	isochorismatase activity
L2Z23_RS08570	COG1535	isochorismatase
L2Z23_RS08585	COG1132	(ABC) transporter
L2Z23_RS08590	COG1132	(ABC) transporter
L2Z23_RS08595	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z23_RS08605	COG1169	isochorismate synthase
L2Z23_RS08620	COG3739	integral membrane protein
L2Z23_RS08645	COG0302	gtp cyclohydrolase
L2Z23_RS08655	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2Z23_RS08685	COG0308	aminopeptidase N
L2Z23_RS08690	COG0512	Glutamine amidotransferase of anthranilate synthase
L2Z23_RS08705	COG0174	glutamine synthetase
L2Z23_RS08715	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Z23_RS08750	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Z23_RS08755	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2Z23_RS08760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z23_RS08780	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z23_RS08785	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Z23_RS08790	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Z23_RS08805	COG1960	acyl-CoA dehydrogenase activity
L2Z23_RS08810	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z23_RS08815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z23_RS08825	COG2223	nitrite transmembrane transporter activity
L2Z23_RS08835	COG0024	Methionine aminopeptidase
L2Z23_RS08840	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Z23_RS08855	COG2207	Transcriptional regulator
L2Z23_RS08880	COG2951	lytic endotransglycosylase activity
L2Z23_RS08885	COG0772	Belongs to the SEDS family
L2Z23_RS08900	COG0842	Transport permease protein
L2Z23_RS08905	COG1131	(ABC) transporter
L2Z23_RS08950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z23_RS08965	COG4215	(ABC) transporter
L2Z23_RS08970	COG4160	amino acid transport
L2Z23_RS08975	COG4598	ABC transporter
L2Z23_RS08985	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z23_RS08990	COG0826	peptidase U32
L2Z23_RS08995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z23_RS09010	COG1720	tRNA m6t6A37 methyltransferase activity
L2Z23_RS09020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Z23_RS09035	COG0642	Histidine kinase
L2Z23_RS09045	COG0494	nUDIX hydrolase
L2Z23_RS09055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Z23_RS09060	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Z23_RS09065	COG3139	Protein of unknown function (DUF1315)
L2Z23_RS09070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Z23_RS09075	COG1301	dicarboxylic acid transport
L2Z23_RS09080	COG1960	acyl-CoA dehydrogenase activity
L2Z23_RS09085	COG2819	hydrolase of the alpha beta superfamily
L2Z23_RS09095	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Z23_RS09105	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2Z23_RS09110	COG1234	tRNA 3'-trailer cleavage
L2Z23_RS09140	COG2363	Small membrane protein
L2Z23_RS09165	COG0513	Belongs to the DEAD box helicase family
L2Z23_RS09175	COG0778	Nitroreductase
L2Z23_RS09205	COG1286	toxin biosynthetic process
L2Z23_RS09230	COG4783	chaperone-mediated protein folding
L2Z23_RS09235	COG1610	YqeY-like protein
L2Z23_RS09335	COG3111	PFAM Bacterial OB fold (BOF) protein
L2Z23_RS09360	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Z23_RS09365	COG0786	glutamate:sodium symporter activity
L2Z23_RS09375	COG2186	Transcriptional regulator
L2Z23_RS09425	COG0477	Major facilitator Superfamily
L2Z23_RS09455	COG2985	domain, Protein
L2Z23_RS09465	COG2995	paraquat-inducible protein a
L2Z23_RS09470	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Z23_RS09470	COG3008	intermembrane lipid transfer
L2Z23_RS09530	COG0138	bifunctional purine biosynthesis protein purh
L2Z23_RS09535	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Z23_RS09565	COG2308	Evidence 4 Homologs of previously reported genes of
L2Z23_RS09575	COG1305	Transglutaminase-like
L2Z23_RS09585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Z23_RS09590	COG0305	Participates in initiation and elongation during chromosome replication
L2Z23_RS09615	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2Z23_RS09625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Z23_RS09630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Z23_RS09655	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z23_RS09655	COG0726	polysaccharide deacetylase
L2Z23_RS09660	COG1215	transferase activity, transferring glycosyl groups
L2Z23_RS09665	COG3658	cytochrome
L2Z23_RS09675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z23_RS09690	COG0583	DNA-binding transcription factor activity
L2Z23_RS09710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z23_RS09715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z23_RS09730	COG1960	acyl-CoA dehydrogenase activity
L2Z23_RS09735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z23_RS09740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z23_RS09765	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2Z23_RS09770	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2Z23_RS09780	COG2205	protein histidine kinase activity
L2Z23_RS09785	COG0745	RESPONSE REGULATOR receiver
L2Z23_RS09790	COG0174	glutamine synthetase
L2Z23_RS09810	COG0729	surface antigen
L2Z23_RS09835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z23_RS09840	COG2814	Major facilitator Superfamily
L2Z23_RS09855	COG0583	DNA-binding transcription factor activity
L2Z23_RS09870	COG1187	pseudouridine synthase activity
L2Z23_RS09890	COG0802	atpase or kinase
L2Z23_RS09895	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Z23_RS09905	COG1923	regulation of RNA biosynthetic process
L2Z23_RS09910	COG0697	spore germination
L2Z23_RS09925	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z23_RS09935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z23_RS09940	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z23_RS09940	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z23_RS09945	COG4302	ethanolamine ammonia-lyase activity
L2Z23_RS09950	COG4303	Ethanolamine ammonia lyase large subunit
L2Z23_RS09955	COG0531	amino acid
L2Z23_RS09975	COG1454	alcohol dehydrogenase
L2Z23_RS09980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z23_RS09990	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
L2Z23_RS10010	COG0308	aminopeptidase N
L2Z23_RS10040	COG1605	Chorismate mutase
L2Z23_RS10060	COG1309	transcriptional regulator
L2Z23_RS10070	COG0668	transmembrane transport
L2Z23_RS10105	COG4773	Receptor
L2Z23_RS10125	COG0488	(ABC) transporter
L2Z23_RS10130	COG0589	response to stress
L2Z23_RS10155	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Z23_RS10165	COG3135	benzoate transporter
L2Z23_RS10170	COG1522	sequence-specific DNA binding
L2Z23_RS10180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z23_RS10185	COG0583	DNA-binding transcription factor activity
L2Z23_RS10195	COG0183	Belongs to the thiolase family
L2Z23_RS10205	COG2030	dehydratase
L2Z23_RS10210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z23_RS10225	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z23_RS10235	COG0824	Thioesterase
L2Z23_RS10240	COG1454	alcohol dehydrogenase
L2Z23_RS10250	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Z23_RS10270	COG0069	glutamate synthase activity
L2Z23_RS10435	COG5410	chromosome segregation
L2Z23_RS10555	COG0739	heme binding
L2Z23_RS10620	COG2814	Major facilitator Superfamily
L2Z23_RS10635	COG0511	ligase activity, forming carbon-carbon bonds
L2Z23_RS10655	COG1116	anion transmembrane transporter activity
L2Z23_RS10655	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z23_RS10660	COG0745	RESPONSE REGULATOR receiver
L2Z23_RS10670	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z23_RS10670	COG2146	nitrite reductase [NAD(P)H] activity
L2Z23_RS10675	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z23_RS10680	COG0243	molybdopterin cofactor binding
L2Z23_RS10690	COG0243	molybdopterin cofactor binding
L2Z23_RS10695	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Z23_RS10710	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Z23_RS10710	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Z23_RS10715	COG0303	'Molybdopterin
L2Z23_RS10725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z23_RS10730	COG0697	spore germination
L2Z23_RS10750	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Z23_RS10755	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z23_RS10810	COG2204	response regulator
L2Z23_RS10815	COG3852	Histidine kinase
L2Z23_RS10835	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Z23_RS10840	COG0575	Belongs to the CDS family
L2Z23_RS10875	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z23_RS10890	COG2137	regulation of response to DNA damage stimulus
L2Z23_RS10900	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Z23_RS10905	COG1011	Hydrolase
L2Z23_RS10930	COG1522	sequence-specific DNA binding
L2Z23_RS10940	COG1113	amino acid transport
L2Z23_RS10960	COG0659	secondary active sulfate transmembrane transporter activity
L2Z23_RS10965	COG2135	peptidase activity
L2Z23_RS10980	COG3300	MHYT domain
L2Z23_RS10980	COG5001	Diguanylate cyclase
L2Z23_RS11000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z23_RS11000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z23_RS11000	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2Z23_RS11005	COG1105	Belongs to the carbohydrate kinase PfkB family
L2Z23_RS11010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Z23_RS11010	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z23_RS11040	COG0024	Methionine aminopeptidase
L2Z23_RS11045	COG0583	DNA-binding transcription factor activity
L2Z23_RS11055	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Z23_RS11060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z23_RS11065	COG0516	GMP reductase activity
L2Z23_RS11065	COG0517	IMP dehydrogenase activity
L2Z23_RS11090	COG0552	protein localization to endoplasmic reticulum
L2Z23_RS11100	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2Z23_RS11115	COG4890	Cyd operon protein YbgT
L2Z23_RS11120	COG1294	oxidase, subunit
L2Z23_RS11140	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2Z23_RS11150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Z23_RS11155	COG4774	siderophore transport
L2Z23_RS11170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Z23_RS11175	COG0569	domain protein
L2Z23_RS11180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z23_RS11210	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Z23_RS11215	COG0542	response to heat
L2Z23_RS11240	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z23_RS11240	COG1902	pentaerythritol trinitrate reductase activity
L2Z23_RS11285	COG2323	membrane
L2Z23_RS11290	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Z23_RS11300	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z23_RS11305	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z23_RS11310	COG0183	Belongs to the thiolase family
L2Z23_RS11315	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Z23_RS11320	COG0596	Alpha beta hydrolase
L2Z23_RS11325	COG2271	Major facilitator Superfamily
L2Z23_RS11330	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z23_RS11335	COG3485	protocatechuate 3,4-dioxygenase
L2Z23_RS11340	COG3485	protocatechuate 3,4-dioxygenase
L2Z23_RS11345	COG0710	3-dehydroquinate dehydratase activity
L2Z23_RS11350	COG3420	alginic acid biosynthetic process
L2Z23_RS11355	COG3659	wide pore channel activity
L2Z23_RS11360	COG4993	Dehydrogenase
L2Z23_RS11370	COG2391	methyltransferase activity
L2Z23_RS11385	COG1414	Transcriptional regulator
L2Z23_RS11390	COG0583	DNA-binding transcription factor activity
L2Z23_RS11395	COG1960	acyl-CoA dehydrogenase activity
L2Z23_RS11420	COG2814	Major facilitator Superfamily
L2Z23_RS11430	COG0154	amidase activity
L2Z23_RS11450	COG4638	Rieske (2fe-2S)
L2Z23_RS11460	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z23_RS11470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z23_RS11480	COG3733	amine oxidase
L2Z23_RS11490	COG1012	belongs to the aldehyde dehydrogenase family
L2Z23_RS11500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z23_RS11505	COG0183	Belongs to the thiolase family
L2Z23_RS11510	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z23_RS11515	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z23_RS11525	COG4829	muconolactone delta-isomerase
L2Z23_RS11530	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z23_RS11535	COG0583	DNA-binding transcription factor activity
L2Z23_RS11545	COG2186	Transcriptional regulator
L2Z23_RS11565	COG1012	belongs to the aldehyde dehydrogenase family
L2Z23_RS11585	COG1960	acyl-CoA dehydrogenase activity
L2Z23_RS11590	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z23_RS11595	COG3829	transcription factor binding
L2Z23_RS11605	COG3162	membrane
L2Z23_RS11620	COG1012	belongs to the aldehyde dehydrogenase family
L2Z23_RS11635	COG0753	catalase activity
L2Z23_RS11655	COG1846	Transcriptional regulator
L2Z23_RS11660	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z23_RS11660	COG1902	pentaerythritol trinitrate reductase activity
L2Z23_RS11670	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L2Z23_RS11700	COG1309	transcriptional regulator
L2Z23_RS11710	COG1335	isochorismatase
L2Z23_RS11715	COG0583	DNA-binding transcription factor activity
L2Z23_RS11725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z23_RS11725	COG0475	glutathione-regulated potassium exporter activity
L2Z23_RS11735	COG1473	amidohydrolase
L2Z23_RS11745	COG2831	hemolysin activation secretion protein
L2Z23_RS11750	COG3210	domain, Protein
L2Z23_RS11780	COG2188	Transcriptional regulator
L2Z23_RS11795	COG0583	DNA-binding transcription factor activity
L2Z23_RS11825	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z23_RS11855	COG1566	PFAM secretion protein HlyD family protein
L2Z23_RS11870	COG1012	belongs to the aldehyde dehydrogenase family
L2Z23_RS11875	COG0129	dihydroxy-acid dehydratase activity
L2Z23_RS11885	COG0583	DNA-binding transcription factor activity
L2Z23_RS11890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z23_RS11900	COG2084	Dehydrogenase
L2Z23_RS11905	COG2207	Transcriptional regulator
L2Z23_RS11920	COG1064	alcohol dehydrogenase
L2Z23_RS11930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z23_RS11935	COG1120	ATPase activity
L2Z23_RS11955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z23_RS12075	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2Z23_RS12125	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z23_RS12140	COG2207	Transcriptional regulator
L2Z23_RS12150	COG2205	protein histidine kinase activity
L2Z23_RS12155	COG0745	RESPONSE REGULATOR receiver
L2Z23_RS12160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z23_RS12165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z23_RS12170	COG1538	Outer membrane efflux protein
L2Z23_RS12180	COG2072	flavoprotein involved in K transport
L2Z23_RS12200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z23_RS12220	COG3539	Fimbrial protein
L2Z23_RS12250	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L2Z23_RS12260	COG0753	catalase activity
L2Z23_RS12275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z23_RS12335	COG1535	isochorismatase
L2Z23_RS12335	COG3433	isochorismatase activity
L2Z23_RS12340	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z23_RS12345	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2Z23_RS12350	COG4149	molybdate abc transporter
L2Z23_RS12355	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2Z23_RS12365	COG4638	Rieske (2fe-2S)
L2Z23_RS12370	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z23_RS12375	COG0543	2 iron, 2 sulfur cluster binding
L2Z23_RS12375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z23_RS12400	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z23_RS12415	COG2207	Transcriptional regulator
L2Z23_RS12425	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z23_RS12430	COG2610	gluconate transmembrane transporter activity
L2Z23_RS12440	COG0583	DNA-binding transcription factor activity
L2Z23_RS12450	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z23_RS12455	COG2031	fatty acid transporter
L2Z23_RS12460	COG0183	Belongs to the thiolase family
L2Z23_RS12465	COG0583	DNA-binding transcription factor activity
L2Z23_RS12470	COG0583	DNA-binding transcription factor activity
L2Z23_RS12485	COG1027	Aspartate ammonia-lyase
L2Z23_RS12495	COG0477	Major facilitator Superfamily
L2Z23_RS12515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z23_RS12520	COG4521	taurine ABC transporter
L2Z23_RS12535	COG2188	Transcriptional regulator
L2Z23_RS12545	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Z23_RS12550	COG1733	regulation of RNA biosynthetic process
L2Z23_RS12555	COG2207	Transcriptional regulator
L2Z23_RS12555	COG3708	Transcriptional regulator
L2Z23_RS12570	COG0730	response to heat
L2Z23_RS12585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z23_RS12585	COG3453	Protein conserved in bacteria
L2Z23_RS12595	COG3781	membrane
L2Z23_RS12600	COG1063	alcohol dehydrogenase
L2Z23_RS12610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z23_RS12615	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z23_RS12620	COG0022	dehydrogenase e1 component
L2Z23_RS12625	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2Z23_RS12630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z23_RS12645	COG3706	GGDEF domain
L2Z23_RS12660	COG0133	tryptophan synthase activity
L2Z23_RS12670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z23_RS12705	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Z23_RS12730	COG2226	methyltransferase
L2Z23_RS12785	COG0842	Transport permease protein
L2Z23_RS12790	COG0842	Transport permease protein
L2Z23_RS12795	COG1131	(ABC) transporter
L2Z23_RS12810	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z23_RS12815	COG4773	Receptor
L2Z23_RS12835	COG0730	response to heat
L2Z23_RS12840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Z23_RS12860	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2Z23_RS12875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z23_RS12915	COG4264	IucA IucC family
L2Z23_RS12920	COG4264	IucA IucC family
L2Z23_RS12940	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Z23_RS12955	COG1960	acyl-CoA dehydrogenase activity
L2Z23_RS12960	COG1960	acyl-CoA dehydrogenase activity
L2Z23_RS12965	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z23_RS12970	COG2207	Transcriptional regulator
L2Z23_RS12975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z23_RS12980	COG0776	regulation of translation
L2Z23_RS13005	COG0822	iron-sulfur transferase activity
L2Z23_RS13010	COG0316	Belongs to the HesB IscA family
L2Z23_RS13040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Z23_RS13060	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z23_RS13065	COG0702	epimerase
L2Z23_RS13100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Z23_RS13110	COG0339	signal peptide processing
L2Z23_RS13180	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Z23_RS13185	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Z23_RS13215	COG0776	regulation of translation
L2Z23_RS13280	COG0084	hydrolase, TatD family'
L2Z23_RS13300	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Z23_RS13305	COG1132	(ABC) transporter
L2Z23_RS13315	COG0811	peptide transport
L2Z23_RS13320	COG1475	DNA binding
L2Z23_RS13325	COG1192	Involved in chromosome partitioning
L2Z23_RS13335	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z23_RS13350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z23_RS13355	COG0191	fructose-bisphosphate aldolase activity
L2Z23_RS13375	COG0424	maF-like protein
L2Z23_RS13380	COG2850	peptidyl-arginine hydroxylation
L2Z23_RS13390	COG0640	Transcriptional regulator
L2Z23_RS13400	COG3619	membrane
L2Z23_RS13405	COG3122	Protein conserved in bacteria
L2Z23_RS13410	COG1132	(ABC) transporter
L2Z23_RS13430	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Z23_RS13435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z23_RS13445	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z23_RS13445	COG0506	proline dehydrogenase activity
L2Z23_RS13445	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z23_RS13450	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2Z23_RS13465	COG3698	Phosphodiester glycosidase
L2Z23_RS13475	COG2353	YceI-like domain
L2Z23_RS13485	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Z23_RS13530	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Z23_RS13530	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Z23_RS13555	COG3539	Fimbrial protein
L2Z23_RS13560	COG3121	Chaperone
L2Z23_RS13585	COG0697	spore germination
L2Z23_RS13595	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z23_RS13605	COG0583	DNA-binding transcription factor activity
L2Z23_RS13625	COG1309	transcriptional regulator
L2Z23_RS13640	COG1522	sequence-specific DNA binding
L2Z23_RS13650	COG1126	abc transporter atp-binding protein
L2Z23_RS13655	COG0765	amino acid transport
L2Z23_RS13660	COG0765	amino acid transport
L2Z23_RS13690	COG1464	Belongs to the NlpA lipoprotein family
L2Z23_RS13700	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z23_RS13705	COG2011	ABC-type metal ion transport system permease component
L2Z23_RS13710	COG0012	GTP binding
L2Z23_RS13735	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z23_RS13775	COG0386	Belongs to the glutathione peroxidase family
L2Z23_RS13785	COG0436	Aminotransferase
L2Z23_RS13825	COG3634	alkyl hydroperoxide reductase activity
L2Z23_RS13840	COG0583	DNA-binding transcription factor activity
L2Z23_RS13845	COG0798	PFAM Bile acid sodium symporter
L2Z23_RS13850	COG0640	Transcriptional regulator
L2Z23_RS13865	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L2Z23_RS13885	COG1953	Uracil, thiamine, allantoin
L2Z23_RS13895	COG2175	clavaminate synthase activity
L2Z23_RS13900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z23_RS13905	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2Z23_RS13910	COG4521	taurine ABC transporter
L2Z23_RS13920	COG0477	Major facilitator Superfamily
L2Z23_RS13940	COG1271	oxidase subunit
L2Z23_RS13945	COG1294	oxidase, subunit
L2Z23_RS13955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z23_RS13975	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Z23_RS13995	COG3052	prosthetic group binding
L2Z23_RS14000	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2Z23_RS14010	COG2814	Major facilitator Superfamily
L2Z23_RS14030	COG1346	cytolysis
L2Z23_RS14040	COG0583	DNA-binding transcription factor activity
L2Z23_RS14045	COG0625	glutathione transferase activity
L2Z23_RS14050	COG0625	glutathione transferase activity
L2Z23_RS14055	COG0583	DNA-binding transcription factor activity
L2Z23_RS14070	COG1045	serine acetyltransferase
L2Z23_RS14075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z23_RS14080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2Z23_RS14090	COG1280	lysine exporter protein (LysE YggA)
L2Z23_RS14105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z23_RS14110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z23_RS14115	COG1126	abc transporter atp-binding protein
L2Z23_RS14120	COG0765	amino acid transport
L2Z23_RS14125	COG0765	amino acid transport
L2Z23_RS14145	COG0784	Response regulator, receiver
L2Z23_RS14145	COG2205	protein histidine kinase activity
L2Z23_RS14165	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Z23_RS14185	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z23_RS14235	COG0583	DNA-binding transcription factor activity
L2Z23_RS14255	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z23_RS14260	COG1309	transcriptional regulator
L2Z23_RS14265	COG1960	acyl-CoA dehydrogenase activity
L2Z23_RS14270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z23_RS14275	COG1024	Enoyl-CoA hydratase
L2Z23_RS14280	COG4770	biotin carboxylase activity
L2Z23_RS14290	COG0583	DNA-binding transcription factor activity
L2Z23_RS14305	COG1960	acyl-CoA dehydrogenase activity
L2Z23_RS14315	COG2814	Major facilitator Superfamily
L2Z23_RS14325	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z23_RS14330	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z23_RS14335	COG2814	Major facilitator Superfamily
L2Z23_RS14340	COG1960	acyl-CoA dehydrogenase activity
L2Z23_RS14345	COG1024	Enoyl-CoA hydratase
L2Z23_RS14350	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z23_RS14355	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z23_RS14360	COG0183	Belongs to the thiolase family
L2Z23_RS14370	COG2814	Major facilitator Superfamily
L2Z23_RS14380	COG1024	Enoyl-CoA hydratase
L2Z23_RS14395	COG1960	acyl-CoA dehydrogenase activity
L2Z23_RS14400	COG2814	Major facilitator Superfamily
L2Z23_RS14405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z23_RS14410	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Z23_RS14425	COG3842	ATPase activity
L2Z23_RS14430	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Z23_RS14440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z23_RS14445	COG1414	Transcriptional regulator
L2Z23_RS14455	COG0583	DNA-binding transcription factor activity
L2Z23_RS14460	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z23_RS14465	COG1012	belongs to the aldehyde dehydrogenase family
L2Z23_RS14475	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z23_RS14485	COG1012	belongs to the aldehyde dehydrogenase family
L2Z23_RS14490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z23_RS14495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z23_RS14500	COG2267	carboxylic ester hydrolase activity
L2Z23_RS14520	COG3038	cytochrome b561
L2Z23_RS14525	COG0753	catalase activity
L2Z23_RS14555	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z23_RS14565	COG3327	negative regulation of DNA-templated transcription, initiation
L2Z23_RS14570	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L2Z23_RS14575	COG0183	Belongs to the thiolase family
L2Z23_RS14580	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z23_RS14585	COG1024	Enoyl-CoA hydratase
L2Z23_RS14590	COG1024	Enoyl-CoA hydratase
L2Z23_RS14595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z23_RS14600	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Z23_RS14605	COG3396	Phenylacetate-CoA oxygenase
L2Z23_RS14610	COG3460	Phenylacetate-CoA oxygenase
L2Z23_RS14615	COG3396	Phenylacetate-CoA oxygenase
L2Z23_RS14620	COG1012	belongs to the aldehyde dehydrogenase family
L2Z23_RS14620	COG2030	dehydratase
L2Z23_RS14625	COG1760	l-serine dehydratase
L2Z23_RS14630	COG0531	amino acid
L2Z23_RS14635	COG1012	belongs to the aldehyde dehydrogenase family
L2Z23_RS14650	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z23_RS14660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z23_RS14680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z23_RS14690	COG0789	Transcriptional regulator
L2Z23_RS14705	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2Z23_RS14720	COG2807	transmembrane transport
L2Z23_RS14725	COG0590	tRNA wobble adenosine to inosine editing
L2Z23_RS14845	COG1116	anion transmembrane transporter activity
L2Z23_RS14850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z23_RS14860	COG0864	Transcriptional regulator
L2Z23_RS14880	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z23_RS14885	COG0439	Biotin carboxylase
L2Z23_RS14900	COG1063	alcohol dehydrogenase
L2Z23_RS14910	COG1309	transcriptional regulator
L2Z23_RS14930	COG0038	chloride channel
L2Z23_RS14935	COG4770	biotin carboxylase activity
L2Z23_RS14955	COG1914	H( )-stimulated, divalent metal cation uptake system
L2Z23_RS14960	COG0583	DNA-binding transcription factor activity
L2Z23_RS15010	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z23_RS15030	COG2814	Major facilitator Superfamily
L2Z23_RS15045	COG1560	Kdo2-lipid A biosynthetic process
L2Z23_RS15055	COG5006	permease, DMT superfamily
L2Z23_RS15060	COG1522	sequence-specific DNA binding
L2Z23_RS15075	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2Z23_RS15085	COG4122	O-methyltransferase activity
L2Z23_RS15115	COG1538	Outer membrane efflux protein
L2Z23_RS15120	COG1137	ATPase activity
L2Z23_RS15125	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2Z23_RS15135	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Z23_RS15140	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L2Z23_RS15140	COG0517	IMP dehydrogenase activity
L2Z23_RS15175	COG2814	Major facilitator Superfamily
L2Z23_RS15210	COG1278	Cold shock
L2Z23_RS15215	COG1280	lysine exporter protein (LysE YggA)
L2Z23_RS15245	COG1570	exodeoxyribonuclease VII activity
L2Z23_RS15295	COG0583	DNA-binding transcription factor activity
L2Z23_RS15305	COG4638	Rieske (2fe-2S)
L2Z23_RS15310	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z23_RS15315	COG0543	2 iron, 2 sulfur cluster binding
L2Z23_RS15315	COG0633	Ferredoxin
L2Z23_RS15320	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z23_RS15325	COG3135	benzoate transporter
L2Z23_RS15330	COG2814	Major facilitator Superfamily
L2Z23_RS15345	COG1643	Atp-dependent helicase
L2Z23_RS15350	COG0450	alkyl hydroperoxide reductase
L2Z23_RS15360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2Z23_RS15370	COG3634	alkyl hydroperoxide reductase activity
L2Z23_RS15390	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2Z23_RS15395	COG0625	glutathione transferase activity
L2Z23_RS15405	COG2885	chlorophyll binding
L2Z23_RS15440	COG0542	response to heat
L2Z23_RS15455	COG1765	OsmC-like protein
L2Z23_RS15475	COG0667	Aldo Keto reductase
L2Z23_RS15490	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Z23_RS15500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Z23_RS15510	COG0527	aspartate kinase activity
L2Z23_RS15520	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2Z23_RS15530	COG3038	cytochrome b561
L2Z23_RS15535	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2Z23_RS15540	COG2252	PERMEase
L2Z23_RS15550	COG2072	flavoprotein involved in K transport
L2Z23_RS15565	COG1741	Belongs to the pirin family
L2Z23_RS15570	COG1309	transcriptional regulator
L2Z23_RS15595	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L2Z23_RS15635	COG1902	pentaerythritol trinitrate reductase activity
L2Z23_RS15635	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z23_RS15645	COG2203	Gaf domain
L2Z23_RS15645	COG3706	GGDEF domain
L2Z23_RS15645	COG4251	negative regulation of phosphorylation
L2Z23_RS15645	COG5001	Diguanylate cyclase
L2Z23_RS15655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z23_RS15675	COG4172	Belongs to the ABC transporter superfamily
L2Z23_RS15680	COG4239	(ABC) transporter, permease
L2Z23_RS15685	COG4174	ABC transporter (Permease)
L2Z23_RS15695	COG0741	lytic transglycosylase activity
L2Z23_RS15695	COG1388	LysM domain
L2Z23_RS15695	COG0741	lytic transglycosylase activity
L2Z23_RS15695	COG1388	LysM domain
L2Z23_RS15700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z23_RS15740	COG0583	DNA-binding transcription factor activity
L2Z23_RS15745	COG1279	arginine transmembrane transporter activity
L2Z23_RS15765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z23_RS15770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z23_RS15775	COG0006	proline dipeptidase activity
L2Z23_RS15815	COG2194	sulfuric ester hydrolase activity
L2Z23_RS16210	COG3384	dioxygenase
L2Z23_RS16220	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z23_RS16225	COG2878	Part of a membrane complex involved in electron transport
L2Z23_RS16230	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Z23_RS16255	COG0768	penicillin binding
L2Z23_RS16260	COG0742	ribosomal rna small subunit methyltransferase
L2Z23_RS16275	COG0830	nickel cation binding
L2Z23_RS16285	COG0804	urea catabolic process
L2Z23_RS16325	COG1253	flavin adenine dinucleotide binding
L2Z23_RS16330	COG2851	Citrate transporter
L2Z23_RS16385	COG1773	rubredoxin
L2Z23_RS16390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z23_RS16400	COG0583	DNA-binding transcription factor activity
L2Z23_RS16425	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Z23_RS16430	COG4181	ATPase activity
L2Z23_RS16475	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z23_RS16495	COG0306	phosphate transporter
L2Z23_RS16505	COG3958	Transketolase
L2Z23_RS16510	COG3959	Transketolase, thiamine diphosphate binding domain
L2Z23_RS16515	COG2271	Major facilitator Superfamily
L2Z23_RS16520	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z23_RS16525	COG0583	DNA-binding transcription factor activity
L2Z23_RS16540	COG2223	nitrite transmembrane transporter activity
L2Z23_RS16545	COG2207	Transcriptional regulator
L2Z23_RS16550	COG2066	Belongs to the glutaminase family
L2Z23_RS16555	COG0242	peptide deformylase activity
L2Z23_RS16560	COG0477	Major facilitator Superfamily
L2Z23_RS16570	COG0028	Belongs to the TPP enzyme family
L2Z23_RS16585	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z23_RS16590	COG2267	carboxylic ester hydrolase activity
L2Z23_RS16600	COG2271	Major facilitator Superfamily
L2Z23_RS16605	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z23_RS16615	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z23_RS16635	COG1414	Transcriptional regulator
L2Z23_RS16650	COG1024	Enoyl-CoA hydratase
L2Z23_RS16660	COG1215	transferase activity, transferring glycosyl groups
L2Z23_RS16665	COG0726	polysaccharide deacetylase
L2Z23_RS16665	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z23_RS16675	COG4681	YaeQ
L2Z23_RS16685	COG0523	cobalamin synthesis protein
L2Z23_RS16695	COG1607	acyl-coa hydrolase
L2Z23_RS16705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z23_RS16710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z23_RS16715	COG1309	transcriptional regulator
L2Z23_RS16740	COG2040	homocysteine
L2Z23_RS16745	COG0531	amino acid
L2Z23_RS16810	COG1595	DNA-templated transcription, initiation
L2Z23_RS16820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z23_RS16825	COG0477	Major facilitator Superfamily
L2Z23_RS16845	COG0084	hydrolase, TatD family'
L2Z23_RS16875	COG2826	transposase and inactivated derivatives, IS30 family
L2Z23_RS16895	COG0629	single-stranded DNA binding
L2Z23_RS16950	COG0582	viral genome integration into host DNA
L2Z23_RS17055	COG0592	DNA-directed DNA polymerase activity
L2Z23_RS17095	COG2026	Addiction module toxin, RelE StbE family
L2Z23_RS17290	COG1484	DNA-dependent DNA replication
L2Z23_RS17380	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z23_RS17450	COG0405	Gamma-glutamyltransferase
L2Z23_RS17455	COG2814	Major facilitator Superfamily
L2Z23_RS17465	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z23_RS17480	COG1090	epimerase
L2Z23_RS17500	COG0420	3'-5' exonuclease activity
L2Z23_RS17525	COG0735	belongs to the Fur family
L2Z23_RS17530	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z23_RS17550	COG0121	glutamine amidotransferase
L2Z23_RS17565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z23_RS17575	COG0210	DNA helicase
L2Z23_RS17580	COG2885	chlorophyll binding
L2Z23_RS17585	COG0204	Acyl-transferase
L2Z23_RS17600	COG2894	cell division
L2Z23_RS17625	COG1280	lysine exporter protein (LysE YggA)
L2Z23_RS17630	COG1674	ftsk spoiiie
L2Z23_RS17630	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Z23_RS17635	COG0492	ferredoxin-NADP+ reductase activity
L2Z23_RS17640	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Z23_RS17650	COG0456	acetyltransferase
L2Z23_RS17695	COG1981	membrane
L2Z23_RS17710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z23_RS17710	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Z23_RS17730	COG1012	belongs to the aldehyde dehydrogenase family
L2Z23_RS17740	COG0657	acetylesterase activity
L2Z23_RS17750	COG0473	3-isopropylmalate dehydrogenase activity
L2Z23_RS17755	COG0583	DNA-binding transcription factor activity
L2Z23_RS17775	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z23_RS17800	COG0564	pseudouridine synthase activity
L2Z23_RS17810	COG0358	DNA primase activity
L2Z23_RS17825	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Z23_RS17855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z23_RS17885	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2Z23_RS17895	COG0351	phosphomethylpyrimidine kinase
L2Z23_RS17895	COG0352	thiamine-phosphate diphosphorylase activity
L2Z23_RS17895	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z23_RS17900	COG1652	LysM domain
L2Z23_RS17930	COG1399	metal-binding, possibly nucleic acid-binding protein
L2Z23_RS17935	COG3101	peptidyl-lysine hydroxylation
L2Z23_RS17940	COG0009	L-threonylcarbamoyladenylate synthase
L2Z23_RS17945	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2Z23_RS17950	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Z23_RS17965	COG4106	trans-aconitate 2-methyltransferase activity
L2Z23_RS17980	COG2226	methyltransferase
L2Z23_RS17980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z23_RS17980	COG0596	Alpha beta hydrolase
L2Z23_RS17985	COG1877	trehalose-phosphatase activity
L2Z23_RS17990	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2Z23_RS17995	COG2223	nitrite transmembrane transporter activity
L2Z23_RS18015	COG1196	nuclear chromosome segregation
L2Z23_RS18025	COG0730	response to heat
L2Z23_RS18040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Z23_RS18050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z23_RS18100	COG0489	protein tyrosine kinase activity
L2Z23_RS18110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z23_RS18110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z23_RS18140	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z23_RS18145	COG2081	HI0933 family
L2Z23_RS18155	COG0668	transmembrane transport
L2Z23_RS18175	COG0583	DNA-binding transcription factor activity
L2Z23_RS18195	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Z23_RS18200	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z23_RS18230	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Z23_RS18270	COG0745	RESPONSE REGULATOR receiver
L2Z23_RS18290	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Z23_RS18300	COG2205	protein histidine kinase activity
L2Z23_RS18365	COG4993	Dehydrogenase
L2Z23_RS18390	COG0384	phenazine biosynthesis protein PhzF
L2Z23_RS18415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z23_RS18430	COG0583	DNA-binding transcription factor activity
L2Z23_RS18460	COG0583	DNA-binding transcription factor activity
L2Z23_RS18475	COG0583	DNA-binding transcription factor activity
L2Z23_RS18480	COG1053	succinate dehydrogenase
L2Z23_RS18490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z23_RS18495	COG2814	Major facilitator Superfamily
L2Z23_RS18500	COG1960	acyl-CoA dehydrogenase activity
L2Z23_RS18505	COG0583	DNA-binding transcription factor activity
L2Z23_RS18510	COG1063	alcohol dehydrogenase
L2Z23_RS18540	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Z23_RS18545	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Z23_RS18550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z23_RS18565	COG3667	copper resistance
L2Z23_RS18570	COG2132	Multicopper oxidase
L2Z23_RS18580	COG0561	phosphatase activity
L2Z23_RS18585	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z23_RS18610	COG1214	PFAM Peptidase M22, glycoprotease
L2Z23_RS18670	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Z23_RS18675	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Z23_RS18680	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine