locus-tag	class	description
L2Z30_RS00035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2Z30_RS00045	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2Z30_RS00085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z30_RS00105	COG1253	flavin adenine dinucleotide binding
L2Z30_RS00115	COG2860	membrane
L2Z30_RS00120	COG0477	Major facilitator Superfamily
L2Z30_RS00130	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z30_RS00145	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Z30_RS00165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z30_RS00210	COG0589	response to stress
L2Z30_RS00215	COG0659	secondary active sulfate transmembrane transporter activity
L2Z30_RS00225	COG1002	Type II restriction enzyme, methylase subunits
L2Z30_RS00230	COG1061	Type III restriction enzyme res subunit
L2Z30_RS00275	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z30_RS00320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z30_RS00360	COG0589	response to stress
L2Z30_RS00365	COG0659	secondary active sulfate transmembrane transporter activity
L2Z30_RS00375	COG1002	Type II restriction enzyme, methylase subunits
L2Z30_RS00380	COG1061	Type III restriction enzyme res subunit
L2Z30_RS00455	COG0347	Belongs to the P(II) protein family
L2Z30_RS00460	COG0004	ammonium transporteR
L2Z30_RS00470	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z30_RS00470	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z30_RS00510	COG0795	lipopolysaccharide-transporting ATPase activity
L2Z30_RS00515	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Z30_RS00520	COG0793	Belongs to the peptidase S41A family
L2Z30_RS00535	COG2197	response regulator
L2Z30_RS00545	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2Z30_RS00555	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z30_RS00560	COG4974	Belongs to the 'phage' integrase family
L2Z30_RS00585	COG0772	Belongs to the SEDS family
L2Z30_RS00590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z30_RS00595	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Z30_RS00600	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z30_RS00625	COG0697	spore germination
L2Z30_RS00630	COG1538	Outer membrane efflux protein
L2Z30_RS00650	COG3275	phosphorelay sensor kinase activity
L2Z30_RS00660	COG0181	hydroxymethylbilane synthase activity
L2Z30_RS00705	COG1716	ATPase activity
L2Z30_RS00710	COG0546	phosphoglycolate phosphatase activity
L2Z30_RS00805	COG0596	Alpha beta hydrolase
L2Z30_RS00810	COG2056	Na+-H+ antiporter family
L2Z30_RS00825	COG0326	Molecular chaperone. Has ATPase activity
L2Z30_RS00840	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2Z30_RS00905	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2Z30_RS00910	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z30_RS00910	COG2169	Transcriptional regulator
L2Z30_RS00940	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Z30_RS00950	COG0497	DNA recombination
L2Z30_RS00965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z30_RS00975	COG0237	dephospho-CoA kinase activity
L2Z30_RS00980	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L2Z30_RS01030	COG0195	Participates in both transcription termination and antitermination
L2Z30_RS01045	COG1320	monovalent cation:proton antiporter activity
L2Z30_RS01050	COG2212	antiporter activity
L2Z30_RS01055	COG1863	multisubunit Na H antiporter MnhE subunit
L2Z30_RS01060	COG0651	ATP synthesis coupled electron transport
L2Z30_RS01065	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Z30_RS01070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z30_RS01070	COG2111	Na H antiporter
L2Z30_RS01085	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Z30_RS01090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z30_RS01105	COG2226	methyltransferase
L2Z30_RS01125	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Z30_RS01130	COG1074	ATP-dependent DNA helicase activity
L2Z30_RS01135	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z30_RS01140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z30_RS01160	COG0598	Magnesium transport protein CorA
L2Z30_RS01165	COG0789	Transcriptional regulator
L2Z30_RS01170	COG0484	heat shock protein binding
L2Z30_RS01180	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L2Z30_RS01185	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z30_RS01185	COG0475	glutathione-regulated potassium exporter activity
L2Z30_RS01190	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Z30_RS01210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z30_RS01220	COG4535	Mg2 and Co2 transporter CorC
L2Z30_RS01225	COG0425	Belongs to the sulfur carrier protein TusA family
L2Z30_RS01230	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2Z30_RS01230	COG0644	oxidoreductase
L2Z30_RS01240	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z30_RS01255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z30_RS01260	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2Z30_RS01300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Z30_RS01315	COG0534	Mate efflux family protein
L2Z30_RS01325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z30_RS01330	COG4221	oxidoreductase activity
L2Z30_RS01335	COG0583	DNA-binding transcription factor activity
L2Z30_RS01350	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z30_RS01355	COG1530	ribonuclease E activity
L2Z30_RS01365	COG0546	phosphoglycolate phosphatase activity
L2Z30_RS01370	COG2378	regulation of single-species biofilm formation
L2Z30_RS01375	COG0625	glutathione transferase activity
L2Z30_RS01385	COG0583	DNA-binding transcription factor activity
L2Z30_RS01450	COG0473	3-isopropylmalate dehydrogenase activity
L2Z30_RS01505	COG1301	dicarboxylic acid transport
L2Z30_RS01515	COG1560	Kdo2-lipid A biosynthetic process
L2Z30_RS01520	COG1280	lysine exporter protein (LysE YggA)
L2Z30_RS01525	COG0488	(ABC) transporter
L2Z30_RS01530	COG2900	Belongs to the SlyX family
L2Z30_RS01540	COG1733	regulation of RNA biosynthetic process
L2Z30_RS01565	COG0210	DNA helicase
L2Z30_RS01570	COG0724	RNA recognition motif
L2Z30_RS01590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z30_RS01590	COG4651	solute:proton antiporter activity
L2Z30_RS01615	COG0788	formyltetrahydrofolate deformylase activity
L2Z30_RS01715	COG2813	Specifically methylates the guanine in position
L2Z30_RS01715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z30_RS01725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z30_RS01735	COG4774	siderophore transport
L2Z30_RS01745	COG0740	serine-type endopeptidase activity
L2Z30_RS01765	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z30_RS01765	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z30_RS01770	COG0857	belongs to the CobB CobQ family
L2Z30_RS01770	COG0280	phosphate acetyltransferase
L2Z30_RS01775	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Z30_RS01790	COG0800	Aldolase
L2Z30_RS01800	COG3265	gluconokinase activity
L2Z30_RS01805	COG1012	belongs to the aldehyde dehydrogenase family
L2Z30_RS01815	COG2267	carboxylic ester hydrolase activity
L2Z30_RS01830	COG0793	Belongs to the peptidase S41A family
L2Z30_RS01865	COG1426	Protein conserved in bacteria
L2Z30_RS01910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z30_RS01920	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z30_RS01935	COG2986	histidine ammonia-lyase
L2Z30_RS01975	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z30_RS01980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L2Z30_RS02000	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2Z30_RS02010	COG1162	GTPase activity
L2Z30_RS02015	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Z30_RS02030	COG1538	Outer membrane efflux protein
L2Z30_RS02035	COG0577	efflux transmembrane transporter activity
L2Z30_RS02035	COG1136	(ABC) transporter
L2Z30_RS02040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z30_RS02065	COG0028	Belongs to the TPP enzyme family
L2Z30_RS02070	COG0440	acetolactate synthase activity
L2Z30_RS02100	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Z30_RS02115	COG0084	hydrolase, TatD family'
L2Z30_RS02130	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Z30_RS02140	COG0583	DNA-binding transcription factor activity
L2Z30_RS02150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z30_RS02155	COG2814	Major facilitator Superfamily
L2Z30_RS02165	COG0697	spore germination
L2Z30_RS02195	COG3622	Belongs to the hyi family
L2Z30_RS02200	COG2084	Dehydrogenase
L2Z30_RS02205	COG1024	Enoyl-CoA hydratase
L2Z30_RS02210	COG5002	protein histidine kinase activity
L2Z30_RS02210	COG2205	protein histidine kinase activity
L2Z30_RS02210	COG0784	Response regulator, receiver
L2Z30_RS02230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z30_RS02240	COG3956	TIGRFAM MazG family protein
L2Z30_RS02245	COG1555	photosystem II stabilization
L2Z30_RS02250	COG0617	tRNA 3'-terminal CCA addition
L2Z30_RS02255	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Z30_RS02275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z30_RS02280	COG3028	Belongs to the UPF0307 family
L2Z30_RS02285	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z30_RS02300	COG0625	glutathione transferase activity
L2Z30_RS02305	COG1238	metal cluster binding
L2Z30_RS02350	COG0072	phenylalanine-tRNA ligase activity
L2Z30_RS02380	COG0248	Ppx GppA phosphatase
L2Z30_RS02390	COG0037	tRNA processing
L2Z30_RS02440	COG1764	response to oxidative stress
L2Z30_RS02445	COG1846	Transcriptional regulator
L2Z30_RS02455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z30_RS02515	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2Z30_RS02520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Z30_RS02525	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Z30_RS02535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L2Z30_RS02585	COG1214	PFAM Peptidase M22, glycoprotease
L2Z30_RS02610	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z30_RS02615	COG0561	phosphatase activity
L2Z30_RS02625	COG2132	Multicopper oxidase
L2Z30_RS02630	COG3667	copper resistance
L2Z30_RS02645	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z30_RS02650	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Z30_RS02655	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Z30_RS02685	COG1063	alcohol dehydrogenase
L2Z30_RS02690	COG0583	DNA-binding transcription factor activity
L2Z30_RS02695	COG1960	acyl-CoA dehydrogenase activity
L2Z30_RS02700	COG2814	Major facilitator Superfamily
L2Z30_RS02705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z30_RS02715	COG1053	succinate dehydrogenase
L2Z30_RS02720	COG0583	DNA-binding transcription factor activity
L2Z30_RS02735	COG0583	DNA-binding transcription factor activity
L2Z30_RS02765	COG0583	DNA-binding transcription factor activity
L2Z30_RS02780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z30_RS02805	COG0384	phenazine biosynthesis protein PhzF
L2Z30_RS02830	COG4993	Dehydrogenase
L2Z30_RS02900	COG2205	protein histidine kinase activity
L2Z30_RS02910	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Z30_RS02930	COG0745	RESPONSE REGULATOR receiver
L2Z30_RS02970	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Z30_RS03000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z30_RS03005	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Z30_RS03025	COG0583	DNA-binding transcription factor activity
L2Z30_RS03045	COG0668	transmembrane transport
L2Z30_RS03055	COG2081	HI0933 family
L2Z30_RS03060	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z30_RS03090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z30_RS03090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z30_RS03100	COG0489	protein tyrosine kinase activity
L2Z30_RS03150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z30_RS03160	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Z30_RS03175	COG0730	response to heat
L2Z30_RS03185	COG1196	nuclear chromosome segregation
L2Z30_RS03205	COG2223	nitrite transmembrane transporter activity
L2Z30_RS03210	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2Z30_RS03215	COG1877	trehalose-phosphatase activity
L2Z30_RS03220	COG2226	methyltransferase
L2Z30_RS03220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z30_RS03220	COG0596	Alpha beta hydrolase
L2Z30_RS03235	COG4106	trans-aconitate 2-methyltransferase activity
L2Z30_RS03250	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Z30_RS03255	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2Z30_RS03260	COG0009	L-threonylcarbamoyladenylate synthase
L2Z30_RS03265	COG3101	peptidyl-lysine hydroxylation
L2Z30_RS03270	COG1399	metal-binding, possibly nucleic acid-binding protein
L2Z30_RS03295	COG1652	LysM domain
L2Z30_RS03300	COG0351	phosphomethylpyrimidine kinase
L2Z30_RS03300	COG0352	thiamine-phosphate diphosphorylase activity
L2Z30_RS03300	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z30_RS03310	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2Z30_RS03340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z30_RS03370	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Z30_RS03385	COG0358	DNA primase activity
L2Z30_RS03395	COG0564	pseudouridine synthase activity
L2Z30_RS03420	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z30_RS03440	COG0583	DNA-binding transcription factor activity
L2Z30_RS03445	COG0473	3-isopropylmalate dehydrogenase activity
L2Z30_RS03455	COG0657	acetylesterase activity
L2Z30_RS03465	COG1012	belongs to the aldehyde dehydrogenase family
L2Z30_RS03485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z30_RS03485	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Z30_RS03500	COG1981	membrane
L2Z30_RS03545	COG0456	acetyltransferase
L2Z30_RS03555	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Z30_RS03560	COG0492	ferredoxin-NADP+ reductase activity
L2Z30_RS03565	COG1674	ftsk spoiiie
L2Z30_RS03565	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Z30_RS03570	COG1280	lysine exporter protein (LysE YggA)
L2Z30_RS03595	COG2894	cell division
L2Z30_RS03610	COG0204	Acyl-transferase
L2Z30_RS03615	COG2885	chlorophyll binding
L2Z30_RS03620	COG0210	DNA helicase
L2Z30_RS03630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z30_RS03645	COG0121	glutamine amidotransferase
L2Z30_RS03665	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z30_RS03670	COG0735	belongs to the Fur family
L2Z30_RS03695	COG0420	3'-5' exonuclease activity
L2Z30_RS03715	COG1090	epimerase
L2Z30_RS03730	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z30_RS03740	COG2814	Major facilitator Superfamily
L2Z30_RS03745	COG0405	Gamma-glutamyltransferase
L2Z30_RS03815	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z30_RS03905	COG1484	DNA-dependent DNA replication
L2Z30_RS03975	COG0659	secondary active sulfate transmembrane transporter activity
L2Z30_RS04115	COG2026	Addiction module toxin, RelE StbE family
L2Z30_RS04155	COG0592	DNA-directed DNA polymerase activity
L2Z30_RS04260	COG0582	viral genome integration into host DNA
L2Z30_RS04315	COG0629	single-stranded DNA binding
L2Z30_RS04350	COG0084	hydrolase, TatD family'
L2Z30_RS04370	COG0477	Major facilitator Superfamily
L2Z30_RS04375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z30_RS04385	COG1595	DNA-templated transcription, initiation
L2Z30_RS04440	COG0531	amino acid
L2Z30_RS04445	COG2040	homocysteine
L2Z30_RS04470	COG1309	transcriptional regulator
L2Z30_RS04475	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z30_RS04480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z30_RS04490	COG1607	acyl-coa hydrolase
L2Z30_RS04500	COG0523	cobalamin synthesis protein
L2Z30_RS04510	COG4681	YaeQ
L2Z30_RS04520	COG0726	polysaccharide deacetylase
L2Z30_RS04520	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z30_RS04525	COG1215	transferase activity, transferring glycosyl groups
L2Z30_RS04535	COG1024	Enoyl-CoA hydratase
L2Z30_RS04550	COG1414	Transcriptional regulator
L2Z30_RS04570	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z30_RS04580	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z30_RS04585	COG2271	Major facilitator Superfamily
L2Z30_RS04595	COG2267	carboxylic ester hydrolase activity
L2Z30_RS04600	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z30_RS04615	COG0028	Belongs to the TPP enzyme family
L2Z30_RS04625	COG0477	Major facilitator Superfamily
L2Z30_RS04630	COG0242	peptide deformylase activity
L2Z30_RS04635	COG2066	Belongs to the glutaminase family
L2Z30_RS04640	COG2207	Transcriptional regulator
L2Z30_RS04645	COG2223	nitrite transmembrane transporter activity
L2Z30_RS04660	COG0583	DNA-binding transcription factor activity
L2Z30_RS04665	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z30_RS04670	COG2271	Major facilitator Superfamily
L2Z30_RS04675	COG3959	Transketolase, thiamine diphosphate binding domain
L2Z30_RS04680	COG3958	Transketolase
L2Z30_RS04690	COG0306	phosphate transporter
L2Z30_RS04710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z30_RS04755	COG4181	ATPase activity
L2Z30_RS04760	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Z30_RS04785	COG0583	DNA-binding transcription factor activity
L2Z30_RS04795	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z30_RS04800	COG1773	rubredoxin
L2Z30_RS04855	COG2851	Citrate transporter
L2Z30_RS04860	COG1253	flavin adenine dinucleotide binding
L2Z30_RS04900	COG0804	urea catabolic process
L2Z30_RS04910	COG0830	nickel cation binding
L2Z30_RS04925	COG0742	ribosomal rna small subunit methyltransferase
L2Z30_RS04930	COG0768	penicillin binding
L2Z30_RS04955	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Z30_RS04960	COG2878	Part of a membrane complex involved in electron transport
L2Z30_RS04965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z30_RS04975	COG3384	dioxygenase
L2Z30_RS05005	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2Z30_RS05330	COG0739	heme binding
L2Z30_RS05375	COG2194	sulfuric ester hydrolase activity
L2Z30_RS05435	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Z30_RS05455	COG0305	Participates in initiation and elongation during chromosome replication
L2Z30_RS05555	COG4695	Portal protein
L2Z30_RS05620	COG0739	heme binding
L2Z30_RS05620	COG1196	nuclear chromosome segregation
L2Z30_RS05620	COG0741	lytic transglycosylase activity
L2Z30_RS05705	COG0006	proline dipeptidase activity
L2Z30_RS05710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z30_RS05715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z30_RS05735	COG1279	arginine transmembrane transporter activity
L2Z30_RS05740	COG0583	DNA-binding transcription factor activity
L2Z30_RS05780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z30_RS05785	COG0741	lytic transglycosylase activity
L2Z30_RS05785	COG1388	LysM domain
L2Z30_RS05785	COG0741	lytic transglycosylase activity
L2Z30_RS05785	COG1388	LysM domain
L2Z30_RS05795	COG4174	ABC transporter (Permease)
L2Z30_RS05805	COG4172	Belongs to the ABC transporter superfamily
L2Z30_RS05830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z30_RS05840	COG3706	GGDEF domain
L2Z30_RS05840	COG5001	Diguanylate cyclase
L2Z30_RS05840	COG2203	Gaf domain
L2Z30_RS05840	COG4251	negative regulation of phosphorylation
L2Z30_RS05850	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z30_RS05850	COG1902	pentaerythritol trinitrate reductase activity
L2Z30_RS05890	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L2Z30_RS05915	COG1309	transcriptional regulator
L2Z30_RS05920	COG1741	Belongs to the pirin family
L2Z30_RS05935	COG2072	flavoprotein involved in K transport
L2Z30_RS05945	COG2252	PERMEase
L2Z30_RS05950	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2Z30_RS05955	COG3038	cytochrome b561
L2Z30_RS05965	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2Z30_RS05975	COG0527	aspartate kinase activity
L2Z30_RS05985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Z30_RS05995	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Z30_RS06010	COG0667	Aldo Keto reductase
L2Z30_RS06030	COG1765	OsmC-like protein
L2Z30_RS06045	COG0542	response to heat
L2Z30_RS06080	COG2885	chlorophyll binding
L2Z30_RS06090	COG0625	glutathione transferase activity
L2Z30_RS06095	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2Z30_RS06115	COG3634	alkyl hydroperoxide reductase activity
L2Z30_RS06125	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2Z30_RS06135	COG0450	alkyl hydroperoxide reductase
L2Z30_RS06140	COG1643	Atp-dependent helicase
L2Z30_RS06155	COG2814	Major facilitator Superfamily
L2Z30_RS06160	COG3135	benzoate transporter
L2Z30_RS06165	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z30_RS06170	COG0543	2 iron, 2 sulfur cluster binding
L2Z30_RS06170	COG0633	Ferredoxin
L2Z30_RS06175	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z30_RS06180	COG4638	Rieske (2fe-2S)
L2Z30_RS06190	COG0583	DNA-binding transcription factor activity
L2Z30_RS06240	COG1570	exodeoxyribonuclease VII activity
L2Z30_RS06275	COG1280	lysine exporter protein (LysE YggA)
L2Z30_RS06280	COG1278	Cold shock
L2Z30_RS06315	COG2814	Major facilitator Superfamily
L2Z30_RS06350	COG0517	IMP dehydrogenase activity
L2Z30_RS06350	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L2Z30_RS06355	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Z30_RS06365	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2Z30_RS06370	COG1137	ATPase activity
L2Z30_RS06375	COG1538	Outer membrane efflux protein
L2Z30_RS06405	COG4122	O-methyltransferase activity
L2Z30_RS06415	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2Z30_RS06430	COG1522	sequence-specific DNA binding
L2Z30_RS06435	COG5006	permease, DMT superfamily
L2Z30_RS06445	COG1560	Kdo2-lipid A biosynthetic process
L2Z30_RS06460	COG2814	Major facilitator Superfamily
L2Z30_RS06480	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z30_RS06530	COG0583	DNA-binding transcription factor activity
L2Z30_RS06535	COG1914	H( )-stimulated, divalent metal cation uptake system
L2Z30_RS06555	COG4770	biotin carboxylase activity
L2Z30_RS06560	COG0038	chloride channel
L2Z30_RS06580	COG1309	transcriptional regulator
L2Z30_RS06590	COG1063	alcohol dehydrogenase
L2Z30_RS06605	COG0439	Biotin carboxylase
L2Z30_RS06610	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z30_RS06630	COG0864	Transcriptional regulator
L2Z30_RS06640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z30_RS06645	COG1116	anion transmembrane transporter activity
L2Z30_RS06765	COG0590	tRNA wobble adenosine to inosine editing
L2Z30_RS06770	COG2807	transmembrane transport
L2Z30_RS06785	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2Z30_RS06800	COG0789	Transcriptional regulator
L2Z30_RS06810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z30_RS06830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z30_RS06840	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z30_RS06855	COG1012	belongs to the aldehyde dehydrogenase family
L2Z30_RS06860	COG0531	amino acid
L2Z30_RS06865	COG1760	l-serine dehydratase
L2Z30_RS06870	COG1012	belongs to the aldehyde dehydrogenase family
L2Z30_RS06870	COG2030	dehydratase
L2Z30_RS06875	COG3396	Phenylacetate-CoA oxygenase
L2Z30_RS06880	COG3460	Phenylacetate-CoA oxygenase
L2Z30_RS06885	COG3396	Phenylacetate-CoA oxygenase
L2Z30_RS06890	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Z30_RS06895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z30_RS06900	COG1024	Enoyl-CoA hydratase
L2Z30_RS06905	COG1024	Enoyl-CoA hydratase
L2Z30_RS06910	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z30_RS06915	COG0183	Belongs to the thiolase family
L2Z30_RS06920	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L2Z30_RS06925	COG3327	negative regulation of DNA-templated transcription, initiation
L2Z30_RS06935	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z30_RS06970	COG0753	catalase activity
L2Z30_RS06975	COG3038	cytochrome b561
L2Z30_RS06995	COG2267	carboxylic ester hydrolase activity
L2Z30_RS07000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z30_RS07005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z30_RS07010	COG1012	belongs to the aldehyde dehydrogenase family
L2Z30_RS07020	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z30_RS07030	COG1012	belongs to the aldehyde dehydrogenase family
L2Z30_RS07035	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z30_RS07040	COG0583	DNA-binding transcription factor activity
L2Z30_RS07050	COG1414	Transcriptional regulator
L2Z30_RS07055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z30_RS07065	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Z30_RS07070	COG3842	ATPase activity
L2Z30_RS07085	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Z30_RS07090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z30_RS07095	COG2814	Major facilitator Superfamily
L2Z30_RS07100	COG1960	acyl-CoA dehydrogenase activity
L2Z30_RS07115	COG1024	Enoyl-CoA hydratase
L2Z30_RS07125	COG2814	Major facilitator Superfamily
L2Z30_RS07135	COG0183	Belongs to the thiolase family
L2Z30_RS07140	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z30_RS07145	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z30_RS07150	COG1024	Enoyl-CoA hydratase
L2Z30_RS07155	COG1960	acyl-CoA dehydrogenase activity
L2Z30_RS07160	COG2814	Major facilitator Superfamily
L2Z30_RS07165	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z30_RS07170	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z30_RS07180	COG2814	Major facilitator Superfamily
L2Z30_RS07190	COG1960	acyl-CoA dehydrogenase activity
L2Z30_RS07205	COG0583	DNA-binding transcription factor activity
L2Z30_RS07215	COG4770	biotin carboxylase activity
L2Z30_RS07220	COG1024	Enoyl-CoA hydratase
L2Z30_RS07225	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z30_RS07230	COG1960	acyl-CoA dehydrogenase activity
L2Z30_RS07235	COG1309	transcriptional regulator
L2Z30_RS07240	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z30_RS07260	COG0583	DNA-binding transcription factor activity
L2Z30_RS07310	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z30_RS07330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Z30_RS07350	COG0784	Response regulator, receiver
L2Z30_RS07350	COG2205	protein histidine kinase activity
L2Z30_RS07370	COG0765	amino acid transport
L2Z30_RS07375	COG0765	amino acid transport
L2Z30_RS07380	COG1126	abc transporter atp-binding protein
L2Z30_RS07390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z30_RS07395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z30_RS07410	COG1280	lysine exporter protein (LysE YggA)
L2Z30_RS07420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2Z30_RS07425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z30_RS07430	COG1045	serine acetyltransferase
L2Z30_RS07445	COG0583	DNA-binding transcription factor activity
L2Z30_RS07450	COG0625	glutathione transferase activity
L2Z30_RS07455	COG0625	glutathione transferase activity
L2Z30_RS07460	COG0583	DNA-binding transcription factor activity
L2Z30_RS07470	COG1346	cytolysis
L2Z30_RS07490	COG2814	Major facilitator Superfamily
L2Z30_RS07500	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2Z30_RS07505	COG3052	prosthetic group binding
L2Z30_RS07525	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Z30_RS07545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z30_RS07555	COG1294	oxidase, subunit
L2Z30_RS07560	COG1271	oxidase subunit
L2Z30_RS07580	COG0477	Major facilitator Superfamily
L2Z30_RS07590	COG4521	taurine ABC transporter
L2Z30_RS07595	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2Z30_RS07600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z30_RS07605	COG2175	clavaminate synthase activity
L2Z30_RS07615	COG1953	Uracil, thiamine, allantoin
L2Z30_RS07625	COG0583	DNA-binding transcription factor activity
L2Z30_RS07635	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L2Z30_RS07650	COG0640	Transcriptional regulator
L2Z30_RS07655	COG0798	PFAM Bile acid sodium symporter
L2Z30_RS07660	COG0583	DNA-binding transcription factor activity
L2Z30_RS07675	COG3634	alkyl hydroperoxide reductase activity
L2Z30_RS07715	COG0436	Aminotransferase
L2Z30_RS07725	COG0386	Belongs to the glutathione peroxidase family
L2Z30_RS07765	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z30_RS07790	COG0012	GTP binding
L2Z30_RS07795	COG2011	ABC-type metal ion transport system permease component
L2Z30_RS07800	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z30_RS07810	COG1464	Belongs to the NlpA lipoprotein family
L2Z30_RS07840	COG0765	amino acid transport
L2Z30_RS07845	COG0765	amino acid transport
L2Z30_RS07850	COG1126	abc transporter atp-binding protein
L2Z30_RS07860	COG1522	sequence-specific DNA binding
L2Z30_RS07875	COG1309	transcriptional regulator
L2Z30_RS07895	COG0583	DNA-binding transcription factor activity
L2Z30_RS07905	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z30_RS07915	COG0697	spore germination
L2Z30_RS07940	COG3121	Chaperone
L2Z30_RS07945	COG3539	Fimbrial protein
L2Z30_RS07970	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Z30_RS07970	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Z30_RS08015	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Z30_RS08025	COG2353	YceI-like domain
L2Z30_RS08035	COG3698	Phosphodiester glycosidase
L2Z30_RS08050	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2Z30_RS08055	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z30_RS08055	COG0506	proline dehydrogenase activity
L2Z30_RS08055	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z30_RS08065	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z30_RS08070	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Z30_RS08090	COG1132	(ABC) transporter
L2Z30_RS08095	COG3122	Protein conserved in bacteria
L2Z30_RS08100	COG3619	membrane
L2Z30_RS08115	COG0640	Transcriptional regulator
L2Z30_RS08125	COG2850	peptidyl-arginine hydroxylation
L2Z30_RS08130	COG0424	maF-like protein
L2Z30_RS08150	COG0191	fructose-bisphosphate aldolase activity
L2Z30_RS08155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z30_RS08170	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z30_RS08180	COG1192	Involved in chromosome partitioning
L2Z30_RS08185	COG1475	DNA binding
L2Z30_RS08190	COG0811	peptide transport
L2Z30_RS08200	COG1132	(ABC) transporter
L2Z30_RS08205	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Z30_RS08225	COG0084	hydrolase, TatD family'
L2Z30_RS08290	COG0776	regulation of translation
L2Z30_RS08320	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Z30_RS08380	COG0305	Participates in initiation and elongation during chromosome replication
L2Z30_RS08635	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Z30_RS08685	COG0339	signal peptide processing
L2Z30_RS08695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Z30_RS08730	COG0702	epimerase
L2Z30_RS08735	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z30_RS08755	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Z30_RS08785	COG0316	Belongs to the HesB IscA family
L2Z30_RS08790	COG0822	iron-sulfur transferase activity
L2Z30_RS08815	COG0776	regulation of translation
L2Z30_RS08820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z30_RS08825	COG2207	Transcriptional regulator
L2Z30_RS08830	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z30_RS08835	COG1960	acyl-CoA dehydrogenase activity
L2Z30_RS08840	COG1960	acyl-CoA dehydrogenase activity
L2Z30_RS08855	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Z30_RS08875	COG4264	IucA IucC family
L2Z30_RS08880	COG4264	IucA IucC family
L2Z30_RS08920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z30_RS08935	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2Z30_RS08955	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Z30_RS08960	COG0730	response to heat
L2Z30_RS08980	COG4773	Receptor
L2Z30_RS08985	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z30_RS09000	COG1131	(ABC) transporter
L2Z30_RS09005	COG0842	Transport permease protein
L2Z30_RS09010	COG0842	Transport permease protein
L2Z30_RS09065	COG2226	methyltransferase
L2Z30_RS09090	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Z30_RS09125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z30_RS09135	COG0133	tryptophan synthase activity
L2Z30_RS09150	COG3706	GGDEF domain
L2Z30_RS09165	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z30_RS09170	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2Z30_RS09175	COG0022	dehydrogenase e1 component
L2Z30_RS09180	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z30_RS09185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z30_RS09195	COG1063	alcohol dehydrogenase
L2Z30_RS09200	COG3781	membrane
L2Z30_RS09210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z30_RS09210	COG3453	Protein conserved in bacteria
L2Z30_RS09225	COG0730	response to heat
L2Z30_RS09240	COG2207	Transcriptional regulator
L2Z30_RS09240	COG3708	Transcriptional regulator
L2Z30_RS09245	COG1733	regulation of RNA biosynthetic process
L2Z30_RS09250	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Z30_RS09260	COG2188	Transcriptional regulator
L2Z30_RS09275	COG4521	taurine ABC transporter
L2Z30_RS09280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z30_RS09300	COG0477	Major facilitator Superfamily
L2Z30_RS09310	COG1027	Aspartate ammonia-lyase
L2Z30_RS09325	COG0583	DNA-binding transcription factor activity
L2Z30_RS09330	COG0583	DNA-binding transcription factor activity
L2Z30_RS09335	COG0183	Belongs to the thiolase family
L2Z30_RS09340	COG2031	fatty acid transporter
L2Z30_RS09345	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z30_RS09355	COG0583	DNA-binding transcription factor activity
L2Z30_RS09365	COG2610	gluconate transmembrane transporter activity
L2Z30_RS09370	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z30_RS09380	COG2207	Transcriptional regulator
L2Z30_RS09395	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z30_RS09420	COG0543	2 iron, 2 sulfur cluster binding
L2Z30_RS09420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z30_RS09425	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z30_RS09430	COG4638	Rieske (2fe-2S)
L2Z30_RS09440	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2Z30_RS09445	COG4149	molybdate abc transporter
L2Z30_RS09450	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2Z30_RS09455	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z30_RS09460	COG3433	isochorismatase activity
L2Z30_RS09460	COG1535	isochorismatase
L2Z30_RS09530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z30_RS09545	COG0753	catalase activity
L2Z30_RS09555	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L2Z30_RS09585	COG3539	Fimbrial protein
L2Z30_RS09605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z30_RS09625	COG2072	flavoprotein involved in K transport
L2Z30_RS09635	COG1538	Outer membrane efflux protein
L2Z30_RS09640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z30_RS09645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z30_RS09650	COG0745	RESPONSE REGULATOR receiver
L2Z30_RS09655	COG2205	protein histidine kinase activity
L2Z30_RS09665	COG2207	Transcriptional regulator
L2Z30_RS09680	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z30_RS09730	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2Z30_RS09860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z30_RS09880	COG1120	ATPase activity
L2Z30_RS09885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z30_RS09895	COG1064	alcohol dehydrogenase
L2Z30_RS09910	COG2207	Transcriptional regulator
L2Z30_RS09915	COG2084	Dehydrogenase
L2Z30_RS09925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z30_RS09930	COG0583	DNA-binding transcription factor activity
L2Z30_RS09940	COG0129	dihydroxy-acid dehydratase activity
L2Z30_RS09945	COG1012	belongs to the aldehyde dehydrogenase family
L2Z30_RS09960	COG1566	PFAM secretion protein HlyD family protein
L2Z30_RS09980	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z30_RS10010	COG0583	DNA-binding transcription factor activity
L2Z30_RS10025	COG2188	Transcriptional regulator
L2Z30_RS10055	COG3210	domain, Protein
L2Z30_RS10060	COG2831	hemolysin activation secretion protein
L2Z30_RS10070	COG1473	amidohydrolase
L2Z30_RS10080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z30_RS10080	COG0475	glutathione-regulated potassium exporter activity
L2Z30_RS10090	COG0583	DNA-binding transcription factor activity
L2Z30_RS10095	COG1335	isochorismatase
L2Z30_RS10105	COG1309	transcriptional regulator
L2Z30_RS10135	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L2Z30_RS10145	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z30_RS10145	COG1902	pentaerythritol trinitrate reductase activity
L2Z30_RS10150	COG1846	Transcriptional regulator
L2Z30_RS10170	COG0753	catalase activity
L2Z30_RS10185	COG1012	belongs to the aldehyde dehydrogenase family
L2Z30_RS10200	COG3162	membrane
L2Z30_RS10210	COG3829	transcription factor binding
L2Z30_RS10215	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z30_RS10220	COG1960	acyl-CoA dehydrogenase activity
L2Z30_RS10240	COG1012	belongs to the aldehyde dehydrogenase family
L2Z30_RS10260	COG2186	Transcriptional regulator
L2Z30_RS10270	COG0583	DNA-binding transcription factor activity
L2Z30_RS10275	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z30_RS10280	COG4829	muconolactone delta-isomerase
L2Z30_RS10290	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z30_RS10295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z30_RS10300	COG0183	Belongs to the thiolase family
L2Z30_RS10305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z30_RS10315	COG1012	belongs to the aldehyde dehydrogenase family
L2Z30_RS10325	COG3733	amine oxidase
L2Z30_RS10335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z30_RS10345	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z30_RS10355	COG4638	Rieske (2fe-2S)
L2Z30_RS10375	COG0154	amidase activity
L2Z30_RS10385	COG2814	Major facilitator Superfamily
L2Z30_RS10410	COG1960	acyl-CoA dehydrogenase activity
L2Z30_RS10415	COG0583	DNA-binding transcription factor activity
L2Z30_RS10420	COG1414	Transcriptional regulator
L2Z30_RS10435	COG2391	methyltransferase activity
L2Z30_RS10445	COG4993	Dehydrogenase
L2Z30_RS10450	COG3659	wide pore channel activity
L2Z30_RS10455	COG3420	alginic acid biosynthetic process
L2Z30_RS10460	COG0710	3-dehydroquinate dehydratase activity
L2Z30_RS10465	COG3485	protocatechuate 3,4-dioxygenase
L2Z30_RS10470	COG3485	protocatechuate 3,4-dioxygenase
L2Z30_RS10475	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z30_RS10480	COG2271	Major facilitator Superfamily
L2Z30_RS10485	COG0596	Alpha beta hydrolase
L2Z30_RS10490	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Z30_RS10495	COG0183	Belongs to the thiolase family
L2Z30_RS10500	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z30_RS10505	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z30_RS10515	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Z30_RS10520	COG2323	membrane
L2Z30_RS10565	COG1902	pentaerythritol trinitrate reductase activity
L2Z30_RS10565	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z30_RS10590	COG0542	response to heat
L2Z30_RS10595	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Z30_RS10625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z30_RS10630	COG0569	domain protein
L2Z30_RS10635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Z30_RS10650	COG4774	siderophore transport
L2Z30_RS10655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Z30_RS10665	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2Z30_RS10680	COG1294	oxidase, subunit
L2Z30_RS10685	COG4890	Cyd operon protein YbgT
L2Z30_RS10700	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2Z30_RS10710	COG0552	protein localization to endoplasmic reticulum
L2Z30_RS10735	COG0516	GMP reductase activity
L2Z30_RS10735	COG0517	IMP dehydrogenase activity
L2Z30_RS10740	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z30_RS10745	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Z30_RS10755	COG0583	DNA-binding transcription factor activity
L2Z30_RS10760	COG0024	Methionine aminopeptidase
L2Z30_RS10790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Z30_RS10790	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z30_RS10795	COG1105	Belongs to the carbohydrate kinase PfkB family
L2Z30_RS10800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z30_RS10800	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2Z30_RS10800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z30_RS10820	COG3300	MHYT domain
L2Z30_RS10820	COG5001	Diguanylate cyclase
L2Z30_RS10835	COG2135	peptidase activity
L2Z30_RS10840	COG0659	secondary active sulfate transmembrane transporter activity
L2Z30_RS10860	COG1113	amino acid transport
L2Z30_RS10870	COG1522	sequence-specific DNA binding
L2Z30_RS10895	COG1011	Hydrolase
L2Z30_RS10900	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Z30_RS10910	COG2137	regulation of response to DNA damage stimulus
L2Z30_RS10925	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z30_RS10960	COG0575	Belongs to the CDS family
L2Z30_RS10965	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Z30_RS10985	COG3852	Histidine kinase
L2Z30_RS10990	COG2204	response regulator
L2Z30_RS11045	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z30_RS11050	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Z30_RS11070	COG0697	spore germination
L2Z30_RS11075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z30_RS11085	COG0303	'Molybdopterin
L2Z30_RS11090	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Z30_RS11090	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Z30_RS11105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Z30_RS11110	COG0243	molybdopterin cofactor binding
L2Z30_RS11120	COG0243	molybdopterin cofactor binding
L2Z30_RS11125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z30_RS11130	COG2146	nitrite reductase [NAD(P)H] activity
L2Z30_RS11130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z30_RS11140	COG0745	RESPONSE REGULATOR receiver
L2Z30_RS11145	COG1116	anion transmembrane transporter activity
L2Z30_RS11145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z30_RS11165	COG0511	ligase activity, forming carbon-carbon bonds
L2Z30_RS11180	COG2814	Major facilitator Superfamily
L2Z30_RS11200	COG0069	glutamate synthase activity
L2Z30_RS11220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Z30_RS11230	COG1454	alcohol dehydrogenase
L2Z30_RS11235	COG0824	Thioesterase
L2Z30_RS11245	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z30_RS11260	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z30_RS11265	COG2030	dehydratase
L2Z30_RS11275	COG0183	Belongs to the thiolase family
L2Z30_RS11285	COG0583	DNA-binding transcription factor activity
L2Z30_RS11290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z30_RS11300	COG1522	sequence-specific DNA binding
L2Z30_RS11305	COG3135	benzoate transporter
L2Z30_RS11325	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Z30_RS11350	COG0589	response to stress
L2Z30_RS11355	COG0488	(ABC) transporter
L2Z30_RS11375	COG4773	Receptor
L2Z30_RS11410	COG0668	transmembrane transport
L2Z30_RS11420	COG1309	transcriptional regulator
L2Z30_RS11440	COG1605	Chorismate mutase
L2Z30_RS11470	COG0308	aminopeptidase N
L2Z30_RS11490	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
L2Z30_RS11500	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z30_RS11505	COG1454	alcohol dehydrogenase
L2Z30_RS11525	COG0531	amino acid
L2Z30_RS11530	COG4303	Ethanolamine ammonia lyase large subunit
L2Z30_RS11535	COG4302	ethanolamine ammonia-lyase activity
L2Z30_RS11540	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z30_RS11540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z30_RS11545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z30_RS11555	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z30_RS11570	COG0697	spore germination
L2Z30_RS11575	COG1923	regulation of RNA biosynthetic process
L2Z30_RS11585	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Z30_RS11590	COG0802	atpase or kinase
L2Z30_RS11610	COG1187	pseudouridine synthase activity
L2Z30_RS11625	COG0583	DNA-binding transcription factor activity
L2Z30_RS11640	COG2814	Major facilitator Superfamily
L2Z30_RS11645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z30_RS11670	COG0729	surface antigen
L2Z30_RS11690	COG0174	glutamine synthetase
L2Z30_RS11695	COG0745	RESPONSE REGULATOR receiver
L2Z30_RS11700	COG2205	protein histidine kinase activity
L2Z30_RS11710	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2Z30_RS11715	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2Z30_RS11740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z30_RS11745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z30_RS11750	COG1960	acyl-CoA dehydrogenase activity
L2Z30_RS11765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z30_RS11770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z30_RS11790	COG0583	DNA-binding transcription factor activity
L2Z30_RS11805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z30_RS11815	COG3658	cytochrome
L2Z30_RS11820	COG1215	transferase activity, transferring glycosyl groups
L2Z30_RS11825	COG0726	polysaccharide deacetylase
L2Z30_RS11825	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z30_RS11850	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Z30_RS11855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Z30_RS11865	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2Z30_RS11890	COG0305	Participates in initiation and elongation during chromosome replication
L2Z30_RS11895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Z30_RS11905	COG1305	Transglutaminase-like
L2Z30_RS11915	COG2308	Evidence 4 Homologs of previously reported genes of
L2Z30_RS11945	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Z30_RS11950	COG0138	bifunctional purine biosynthesis protein purh
L2Z30_RS11955	COG0151	Belongs to the GarS family
L2Z30_RS11960	COG1464	Belongs to the NlpA lipoprotein family
L2Z30_RS11965	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z30_RS11970	COG2011	ABC-type metal ion transport system permease component
L2Z30_RS11975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z30_RS11985	COG1301	dicarboxylic acid transport
L2Z30_RS12020	COG3008	intermembrane lipid transfer
L2Z30_RS12020	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Z30_RS12025	COG2995	paraquat-inducible protein a
L2Z30_RS12035	COG2985	domain, Protein
L2Z30_RS12065	COG0477	Major facilitator Superfamily
L2Z30_RS12115	COG2186	Transcriptional regulator
L2Z30_RS12125	COG0786	glutamate:sodium symporter activity
L2Z30_RS12130	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Z30_RS12155	COG3111	PFAM Bacterial OB fold (BOF) protein
L2Z30_RS12255	COG1610	YqeY-like protein
L2Z30_RS12260	COG4783	chaperone-mediated protein folding
L2Z30_RS12285	COG1286	toxin biosynthetic process
L2Z30_RS12315	COG0778	Nitroreductase
L2Z30_RS12325	COG0513	Belongs to the DEAD box helicase family
L2Z30_RS12350	COG2363	Small membrane protein
L2Z30_RS12380	COG1234	tRNA 3'-trailer cleavage
L2Z30_RS12385	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2Z30_RS12395	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Z30_RS12405	COG2819	hydrolase of the alpha beta superfamily
L2Z30_RS12410	COG1960	acyl-CoA dehydrogenase activity
L2Z30_RS12415	COG1301	dicarboxylic acid transport
L2Z30_RS12420	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Z30_RS12425	COG3139	Protein of unknown function (DUF1315)
L2Z30_RS12430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Z30_RS12435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Z30_RS12445	COG0494	nUDIX hydrolase
L2Z30_RS12455	COG0642	Histidine kinase
L2Z30_RS12470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Z30_RS12480	COG1720	tRNA m6t6A37 methyltransferase activity
L2Z30_RS12495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z30_RS12500	COG0826	peptidase U32
L2Z30_RS12505	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z30_RS12515	COG4598	ABC transporter
L2Z30_RS12520	COG4160	amino acid transport
L2Z30_RS12525	COG4215	(ABC) transporter
L2Z30_RS12540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z30_RS12585	COG1131	(ABC) transporter
L2Z30_RS12590	COG0842	Transport permease protein
L2Z30_RS12605	COG0772	Belongs to the SEDS family
L2Z30_RS12610	COG2951	lytic endotransglycosylase activity
L2Z30_RS12635	COG2207	Transcriptional regulator
L2Z30_RS12650	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Z30_RS12655	COG0024	Methionine aminopeptidase
L2Z30_RS12665	COG2223	nitrite transmembrane transporter activity
L2Z30_RS12675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z30_RS12680	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z30_RS12710	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Z30_RS12715	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Z30_RS12720	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z30_RS12740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z30_RS12745	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2Z30_RS12750	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Z30_RS12785	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Z30_RS12795	COG0174	glutamine synthetase
L2Z30_RS12810	COG0582	viral genome integration into host DNA
L2Z30_RS12890	COG0739	heme binding
L2Z30_RS12935	COG1598	PFAM Uncharacterised protein family UPF0150
L2Z30_RS13030	COG5410	chromosome segregation
L2Z30_RS13125	COG0305	Participates in initiation and elongation during chromosome replication
L2Z30_RS13230	COG0512	Glutamine amidotransferase of anthranilate synthase
L2Z30_RS13235	COG0308	aminopeptidase N
L2Z30_RS13265	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2Z30_RS13275	COG0302	gtp cyclohydrolase
L2Z30_RS13300	COG3739	integral membrane protein
L2Z30_RS13315	COG1169	isochorismate synthase
L2Z30_RS13325	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z30_RS13330	COG1132	(ABC) transporter
L2Z30_RS13335	COG1132	(ABC) transporter
L2Z30_RS13350	COG3433	isochorismatase activity
L2Z30_RS13350	COG1535	isochorismatase
L2Z30_RS13355	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z30_RS13360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z30_RS13370	COG4774	siderophore transport
L2Z30_RS13375	COG4607	ABC-type enterochelin transport system periplasmic component
L2Z30_RS13380	COG4604	ABC transporter, ATP-binding protein
L2Z30_RS13385	COG4605	iron ion homeostasis
L2Z30_RS13390	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z30_RS13395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z30_RS13410	COG2964	Protein conserved in bacteria
L2Z30_RS13420	COG1741	Belongs to the pirin family
L2Z30_RS13440	COG1309	transcriptional regulator
L2Z30_RS13450	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z30_RS13455	COG2814	Major facilitator Superfamily
L2Z30_RS13490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z30_RS13490	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2Z30_RS13495	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z30_RS13505	COG1012	belongs to the aldehyde dehydrogenase family
L2Z30_RS13515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z30_RS13520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z30_RS13525	COG0583	DNA-binding transcription factor activity
L2Z30_RS13530	COG1113	amino acid transport
L2Z30_RS13550	COG2508	Transcriptional regulator
L2Z30_RS13550	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L2Z30_RS13585	COG2879	small protein
L2Z30_RS13590	COG1966	Carbon starvation protein
L2Z30_RS13635	COG1067	ATP-dependent peptidase activity
L2Z30_RS13640	COG0583	DNA-binding transcription factor activity
L2Z30_RS13665	COG1686	Belongs to the peptidase S11 family
L2Z30_RS13670	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Z30_RS13700	COG3328	transposase activity
L2Z30_RS13715	COG0616	signal peptide processing
L2Z30_RS13720	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Z30_RS13730	COG0573	inorganic phosphate transmembrane transporter activity
L2Z30_RS13735	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Z30_RS13740	COG1113	amino acid transport
L2Z30_RS13745	COG3961	Belongs to the TPP enzyme family
L2Z30_RS13750	COG1522	sequence-specific DNA binding
L2Z30_RS13760	COG0076	glutamate decarboxylase activity
L2Z30_RS13765	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z30_RS13775	COG1309	transcriptional regulator
L2Z30_RS13790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z30_RS13825	COG0352	thiamine-phosphate diphosphorylase activity
L2Z30_RS13850	COG0612	Peptidase, M16
L2Z30_RS13870	COG1823	symporter activity
L2Z30_RS13875	COG0583	DNA-binding transcription factor activity
L2Z30_RS13880	COG0477	Major facilitator Superfamily
L2Z30_RS13905	COG1187	pseudouridine synthase activity
L2Z30_RS13920	COG1686	Belongs to the peptidase S11 family
L2Z30_RS13925	COG1252	NADH dehydrogenase
L2Z30_RS13935	COG0415	Belongs to the DNA photolyase family
L2Z30_RS13950	COG1215	transferase activity, transferring glycosyl groups
L2Z30_RS13980	COG2070	2-Nitropropane dioxygenase
L2Z30_RS14035	COG0556	nucleotide-excision repair
L2Z30_RS14055	COG0436	Aminotransferase
L2Z30_RS14085	COG4221	oxidoreductase activity
L2Z30_RS14095	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Z30_RS14100	COG1381	Involved in DNA repair and RecF pathway recombination
L2Z30_RS14110	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Z30_RS14125	COG0681	Belongs to the peptidase S26 family
L2Z30_RS14140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z30_RS14160	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Z30_RS14165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2Z30_RS14170	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2Z30_RS14180	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2Z30_RS14185	COG4208	sulfate ABC transporter
L2Z30_RS14190	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2Z30_RS14195	COG0583	DNA-binding transcription factor activity
L2Z30_RS14200	COG4625	pathogenesis
L2Z30_RS14215	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2Z30_RS14230	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Z30_RS14240	COG1051	belongs to the nudix hydrolase family
L2Z30_RS14240	COG1056	cytidyltransferase-related domain
L2Z30_RS14245	COG1024	Enoyl-CoA hydratase
L2Z30_RS14255	COG2814	Major facilitator Superfamily
L2Z30_RS14260	COG0047	phosphoribosylformylglycinamidine synthase activity
L2Z30_RS14260	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2Z30_RS14280	COG1473	amidohydrolase
L2Z30_RS14285	COG0824	Thioesterase
L2Z30_RS14305	COG0823	Involved in the tonB-independent uptake of proteins
L2Z30_RS14325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z30_RS14360	COG0628	permease
L2Z30_RS14370	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Z30_RS14375	COG0596	Alpha beta hydrolase
L2Z30_RS14380	COG0616	signal peptide processing
L2Z30_RS14380	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Z30_RS14390	COG2333	competence protein COMEC
L2Z30_RS14390	COG0658	competence protein
L2Z30_RS14395	COG1136	(ABC) transporter
L2Z30_RS14400	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Z30_RS14435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z30_RS14455	COG0463	Glycosyl transferase, family 2
L2Z30_RS14485	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z30_RS14490	COG1280	lysine exporter protein (LysE YggA)
L2Z30_RS14500	COG0019	diaminopimelate decarboxylase activity
L2Z30_RS14510	COG1113	amino acid transport
L2Z30_RS14525	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Z30_RS14535	COG3339	Conserved Protein
L2Z30_RS14540	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2Z30_RS14545	COG0243	molybdopterin cofactor binding
L2Z30_RS14550	COG1929	Belongs to the glycerate kinase type-1 family
L2Z30_RS14565	COG0778	Nitroreductase
L2Z30_RS14595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z30_RS14610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z30_RS14630	COG0741	lytic transglycosylase activity
L2Z30_RS14650	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z30_RS14680	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z30_RS14685	COG1597	lipid kinase activity
L2Z30_RS14700	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2Z30_RS14705	COG0477	Major facilitator Superfamily
L2Z30_RS14755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Z30_RS14760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z30_RS14785	COG0505	Belongs to the CarA family
L2Z30_RS14805	COG0589	response to stress
L2Z30_RS14820	COG2843	Capsule synthesis protein
L2Z30_RS14840	COG2321	neutral zinc metallopeptidase
L2Z30_RS14845	COG2354	Protein conserved in bacteria
L2Z30_RS14865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z30_RS14890	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Z30_RS14895	COG1053	succinate dehydrogenase
L2Z30_RS14900	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Z30_RS14905	COG2009	succinate dehydrogenase
L2Z30_RS14945	COG2921	Belongs to the UPF0250 family
L2Z30_RS14950	COG0321	lipoyl(octanoyl) transferase activity
L2Z30_RS14965	COG0531	amino acid
L2Z30_RS14975	COG1733	regulation of RNA biosynthetic process
L2Z30_RS14980	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Z30_RS14985	COG1648	precorrin-2 dehydrogenase activity
L2Z30_RS14985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Z30_RS15000	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Z30_RS15030	COG0671	phosphoesterase, PA-phosphatase related
L2Z30_RS15035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z30_RS15045	COG1538	Outer membrane efflux protein
L2Z30_RS15050	COG0393	Putative heavy-metal-binding
L2Z30_RS15055	COG0393	Putative heavy-metal-binding
L2Z30_RS15065	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z30_RS15075	COG0525	valine-tRNA ligase activity
L2Z30_RS15095	COG0583	DNA-binding transcription factor activity
L2Z30_RS15100	COG0004	ammonium transporteR
L2Z30_RS15110	COG0642	Histidine kinase
L2Z30_RS15115	COG0745	RESPONSE REGULATOR receiver
L2Z30_RS15120	COG2194	sulfuric ester hydrolase activity
L2Z30_RS15140	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z30_RS15155	COG2315	Protein conserved in bacteria
L2Z30_RS15160	COG0142	geranyltranstransferase activity
L2Z30_RS15165	COG2828	Protein conserved in bacteria
L2Z30_RS15170	COG1113	amino acid transport
L2Z30_RS15180	COG0582	viral genome integration into host DNA
L2Z30_RS15240	COG0739	heme binding
L2Z30_RS15240	COG0741	lytic transglycosylase activity
L2Z30_RS15240	COG1196	nuclear chromosome segregation
L2Z30_RS15300	COG4695	Portal protein
L2Z30_RS15525	COG2207	Transcriptional regulator
L2Z30_RS15550	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z30_RS15560	COG0560	Phosphoserine phosphatase
L2Z30_RS15570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z30_RS15580	COG1530	ribonuclease E activity
L2Z30_RS15585	COG0424	maF-like protein
L2Z30_RS15590	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2Z30_RS15595	COG1792	Involved in formation and maintenance of cell shape
L2Z30_RS15600	COG1077	Cell shape determining protein MreB Mrl
L2Z30_RS15605	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z30_RS15615	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z30_RS15655	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2Z30_RS15660	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z30_RS15665	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z30_RS15670	COG1115	amino acid carrier protein
L2Z30_RS15690	COG2814	Major facilitator Superfamily
L2Z30_RS15695	COG1289	transmembrane transporter activity
L2Z30_RS15705	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Z30_RS15745	COG1376	ErfK ybiS ycfS ynhG family protein
L2Z30_RS15750	COG2832	Protein of unknown function (DUF454)
L2Z30_RS15760	COG5510	response to toxic substance
L2Z30_RS15780	COG0840	transmembrane signaling receptor activity
L2Z30_RS15820	COG3422	double-strand break repair
L2Z30_RS15825	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Z30_RS15830	COG3189	MarR family transcriptional regulator
L2Z30_RS15840	COG0354	folic acid binding
L2Z30_RS15845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z30_RS15855	COG0679	Auxin Efflux Carrier
L2Z30_RS15860	COG1902	pentaerythritol trinitrate reductase activity
L2Z30_RS15880	COG2094	Belongs to the DNA glycosylase MPG family
L2Z30_RS15905	COG1217	gtp-binding protein TYPA
L2Z30_RS15910	COG2233	PERMEase
L2Z30_RS15920	COG0833	amino acid
L2Z30_RS15925	COG1690	Belongs to the RtcB family
L2Z30_RS15935	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L2Z30_RS15935	COG2885	chlorophyll binding
L2Z30_RS15945	COG0183	Belongs to the thiolase family
L2Z30_RS15965	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z30_RS15985	COG2207	Transcriptional regulator
L2Z30_RS15990	COG0183	Belongs to the thiolase family
L2Z30_RS16020	COG1272	protein, Hemolysin III
L2Z30_RS16025	COG0477	Major facilitator Superfamily
L2Z30_RS16040	COG0450	alkyl hydroperoxide reductase
L2Z30_RS16060	COG0285	dihydrofolate synthase activity
L2Z30_RS16110	COG2096	Adenosyltransferase
L2Z30_RS16130	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Z30_RS16135	COG0745	RESPONSE REGULATOR receiver
L2Z30_RS16140	COG2205	protein histidine kinase activity
L2Z30_RS16150	COG1960	acyl-CoA dehydrogenase activity
L2Z30_RS16155	COG1960	acyl-CoA dehydrogenase activity
L2Z30_RS16160	COG0583	DNA-binding transcription factor activity
L2Z30_RS16165	COG0625	glutathione transferase activity
L2Z30_RS16230	COG0438	transferase activity, transferring glycosyl groups
L2Z30_RS16235	COG0463	Glycosyl transferase, family 2
L2Z30_RS16240	COG0726	polysaccharide deacetylase
L2Z30_RS16260	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Z30_RS16265	COG2205	protein histidine kinase activity
L2Z30_RS16295	COG1862	Preprotein translocase
L2Z30_RS16305	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2Z30_RS16310	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Z30_RS16320	COG3781	membrane
L2Z30_RS16325	COG0613	PHP domain protein
L2Z30_RS16335	COG2350	Protein conserved in bacteria
L2Z30_RS16365	COG1607	acyl-coa hydrolase
L2Z30_RS16425	COG2199	diguanylate cyclase activity
L2Z30_RS16435	COG1408	metallophosphoesterase
L2Z30_RS16440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z30_RS16450	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Z30_RS16470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z30_RS16475	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Z30_RS16490	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Z30_RS16500	COG2969	positive regulation of protein catabolic process
L2Z30_RS16520	COG1960	acyl-CoA dehydrogenase activity
L2Z30_RS16525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z30_RS16540	COG1309	transcriptional regulator
L2Z30_RS16545	COG1960	acyl-CoA dehydrogenase activity
L2Z30_RS16590	COG1183	phosphatidylcholine synthase activity
L2Z30_RS16595	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Z30_RS16625	COG0739	heme binding
L2Z30_RS16625	COG0741	lytic transglycosylase activity
L2Z30_RS16625	COG1196	nuclear chromosome segregation
L2Z30_RS16635	COG1702	phosphate starvation-inducible protein PhoH
L2Z30_RS16670	COG1295	ribonuclease BN
L2Z30_RS16675	COG0697	spore germination
L2Z30_RS16680	COG2169	Transcriptional regulator
L2Z30_RS16685	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Z30_RS16730	COG0557	exoribonuclease II activity
L2Z30_RS16735	COG0339	signal peptide processing
L2Z30_RS16740	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2Z30_RS16770	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Z30_RS16775	COG1960	acyl-CoA dehydrogenase activity
L2Z30_RS16930	COG0626	cystathionine gamma-synthase activity
L2Z30_RS16935	COG0433	COG0433 Predicted ATPase
L2Z30_RS16940	COG1017	nitric oxide dioxygenase activity
L2Z30_RS16940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z30_RS16945	COG1959	2 iron, 2 sulfur cluster binding
L2Z30_RS16960	COG1301	dicarboxylic acid transport
L2Z30_RS16965	COG1946	Acyl-CoA thioesterase
L2Z30_RS16985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2Z30_RS16990	COG1040	competence protein
L2Z30_RS16995	COG0494	nUDIX hydrolase
L2Z30_RS17005	COG0598	Magnesium transport protein CorA
L2Z30_RS17015	COG2854	intermembrane phospholipid transfer
L2Z30_RS17025	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Z30_RS17030	COG1127	ABC transporter
L2Z30_RS17040	COG0513	Belongs to the DEAD box helicase family
L2Z30_RS17060	COG0408	coproporphyrinogen oxidase activity
L2Z30_RS17075	COG1960	acyl-CoA dehydrogenase activity
L2Z30_RS17085	COG1983	PspC domain protein
L2Z30_RS17090	COG0517	IMP dehydrogenase activity
L2Z30_RS17135	COG0583	DNA-binding transcription factor activity
L2Z30_RS17175	COG1012	belongs to the aldehyde dehydrogenase family
L2Z30_RS17185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z30_RS17190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z30_RS17195	COG0833	amino acid
L2Z30_RS17225	COG1192	Involved in chromosome partitioning
L2Z30_RS17230	COG0628	permease
L2Z30_RS17240	COG1289	transmembrane transporter activity
L2Z30_RS17255	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z30_RS17260	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2Z30_RS17270	COG0277	FAD linked oxidase domain protein
L2Z30_RS17275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Z30_RS17300	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Z30_RS17305	COG5380	lipid catabolic process
L2Z30_RS17325	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Z30_RS17375	COG0194	GDP metabolic process
L2Z30_RS17390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z30_RS17410	COG3307	-O-antigen
L2Z30_RS17430	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2Z30_RS17435	COG1704	LemA family
L2Z30_RS17445	COG0493	'glutamate synthase
L2Z30_RS17450	COG0067	glutamate synthase
L2Z30_RS17450	COG0069	glutamate synthase activity
L2Z30_RS17450	COG0070	glutamate synthase
L2Z30_RS17500	COG2226	methyltransferase
L2Z30_RS17515	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Z30_RS17520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Z30_RS17565	COG0833	amino acid
L2Z30_RS17650	COG0488	(ABC) transporter
L2Z30_RS17655	COG2873	o-acetylhomoserine
L2Z30_RS17660	COG4221	oxidoreductase activity
L2Z30_RS17665	COG0659	secondary active sulfate transmembrane transporter activity
L2Z30_RS17690	COG0427	acetyl-CoA hydrolase
L2Z30_RS17720	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Z30_RS17750	COG2329	Antibiotic biosynthesis monooxygenase
L2Z30_RS17765	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Z30_RS17830	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z30_RS17835	COG1733	regulation of RNA biosynthetic process
L2Z30_RS17870	COG0667	Aldo Keto reductase
L2Z30_RS17890	COG0583	DNA-binding transcription factor activity
L2Z30_RS17895	COG2814	Major facilitator Superfamily
L2Z30_RS17935	COG1335	isochorismatase
L2Z30_RS17945	COG1012	belongs to the aldehyde dehydrogenase family
L2Z30_RS17950	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z30_RS17960	COG1113	amino acid transport
L2Z30_RS17970	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z30_RS17985	COG2814	Major facilitator Superfamily
L2Z30_RS17995	COG0351	phosphomethylpyrimidine kinase
L2Z30_RS17995	COG0352	thiamine-phosphate diphosphorylase activity
L2Z30_RS17995	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z30_RS18015	COG1309	transcriptional regulator
L2Z30_RS18020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2Z30_RS18040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z30_RS18050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z30_RS18055	COG3162	membrane
L2Z30_RS18060	COG2198	Histidine kinase
L2Z30_RS18060	COG0784	Response regulator, receiver
L2Z30_RS18060	COG2205	protein histidine kinase activity
L2Z30_RS18085	COG3328	transposase activity
L2Z30_RS18090	COG1522	sequence-specific DNA binding
L2Z30_RS18095	COG1335	isochorismatase
L2Z30_RS18100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z30_RS18110	COG0668	transmembrane transport
L2Z30_RS18115	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z30_RS18120	COG1519	Transferase
L2Z30_RS18125	COG1902	pentaerythritol trinitrate reductase activity
L2Z30_RS18145	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2Z30_RS18170	COG0426	domain, Protein
L2Z30_RS18170	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z30_RS18175	COG4774	siderophore transport
L2Z30_RS18180	COG2119	membrane
L2Z30_RS18190	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z30_RS18200	COG4942	peptidase
L2Z30_RS18215	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Z30_RS18225	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Z30_RS18245	COG0189	ligase activity
L2Z30_RS18265	COG0708	Exodeoxyribonuclease III
L2Z30_RS18270	COG1393	Belongs to the ArsC family
L2Z30_RS18285	COG3706	GGDEF domain
L2Z30_RS18320	COG2351	hydroxyisourate hydrolase activity
L2Z30_RS18325	COG2233	PERMEase
L2Z30_RS18335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z30_RS18345	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2Z30_RS18350	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z30_RS18360	COG3150	esterase
L2Z30_RS18375	COG1388	LysM domain
L2Z30_RS18375	COG0791	NLP P60 protein
L2Z30_RS18390	COG2918	glutathione biosynthetic process
L2Z30_RS18405	COG2733	membrane
L2Z30_RS18410	COG0436	Aminotransferase
L2Z30_RS18415	COG0534	Mate efflux family protein
L2Z30_RS18515	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2Z30_RS18520	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Z30_RS18530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2Z30_RS18535	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z30_RS18550	COG0010	Belongs to the arginase family
L2Z30_RS18580	COG2188	Transcriptional regulator
L2Z30_RS18590	COG0523	cobalamin synthesis protein
L2Z30_RS18600	COG1113	amino acid transport
L2Z30_RS18610	COG0625	glutathione transferase activity
L2Z30_RS18630	COG1683	Conserved Protein
L2Z30_RS18635	COG0534	Mate efflux family protein
L2Z30_RS18640	COG0385	Bile acid
L2Z30_RS18645	COG1335	isochorismatase
L2Z30_RS18650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z30_RS18670	COG2116	formate transmembrane transporter activity
L2Z30_RS18675	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Z30_RS18680	COG2133	pyrroloquinoline quinone binding
L2Z30_RS18685	COG2983	Belongs to the UPF0260 family
L2Z30_RS18705	COG1194	a g-specific adenine glycosylase
L2Z30_RS18720	COG2818	Glycosylase
L2Z30_RS18725	COG1064	alcohol dehydrogenase
L2Z30_RS18730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z30_RS18745	COG0583	DNA-binding transcription factor activity
L2Z30_RS18750	COG0656	L-ascorbic acid biosynthetic process
L2Z30_RS18755	COG2814	Major facilitator Superfamily
L2Z30_RS18790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z30_RS18805	COG2233	PERMEase
L2Z30_RS18845	COG0733	neurotransmitter:sodium symporter activity
L2Z30_RS18885	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2Z30_RS18890	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2Z30_RS18895	COG0596	Alpha beta hydrolase
L2Z30_RS18920	COG0488	(ABC) transporter
L2Z30_RS18925	COG0586	Pfam SNARE associated Golgi protein
L2Z30_RS18935	COG0187	DNA topoisomerase II activity
L2Z30_RS18945	COG0592	DNA-directed DNA polymerase activity
L2Z30_RS18970	COG0706	membrane insertase activity
L2Z30_RS18985	COG1230	cation diffusion facilitator family transporter
L2Z30_RS18990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z30_RS19005	COG0402	S-adenosylhomocysteine deaminase activity
L2Z30_RS19015	COG0754	glutathionylspermidine amidase activity
L2Z30_RS19025	COG0861	Integral membrane protein TerC family
L2Z30_RS19030	COG0671	phosphoesterase, PA-phosphatase related
L2Z30_RS19040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Z30_RS19055	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Z30_RS19060	COG2951	lytic endotransglycosylase activity
L2Z30_RS19090	COG0583	DNA-binding transcription factor activity
L2Z30_RS19110	COG0657	acetylesterase activity
L2Z30_RS19115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2Z30_RS19155	COG1047	Peptidyl-prolyl cis-trans
L2Z30_RS19165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Z30_RS19170	COG0196	riboflavin kinase activity
L2Z30_RS19180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2Z30_RS19185	COG1309	transcriptional regulator
L2Z30_RS19190	COG1116	anion transmembrane transporter activity
L2Z30_RS19195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z30_RS19200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z30_RS19205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z30_RS19210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z30_RS19230	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z30_RS19235	COG0546	phosphoglycolate phosphatase activity
L2Z30_RS19290	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2Z30_RS19295	COG0728	peptidoglycan biosynthetic process
L2Z30_RS19320	COG1596	polysaccharide export
L2Z30_RS19325	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z30_RS19385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L2Z30_RS19390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L2Z30_RS19395	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Z30_RS19410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z30_RS19415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z30_RS19425	COG2186	Transcriptional regulator
L2Z30_RS19435	COG0277	FAD linked oxidase domain protein
L2Z30_RS19440	COG1448	Aminotransferase
L2Z30_RS19450	COG1802	Transcriptional regulator
L2Z30_RS19465	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2Z30_RS19525	COG0564	pseudouridine synthase activity
L2Z30_RS19565	COG0251	oxidation-reduction process
L2Z30_RS19570	COG1113	amino acid transport
L2Z30_RS19575	COG1113	amino acid transport
L2Z30_RS19595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z30_RS19600	COG1960	acyl-CoA dehydrogenase activity
L2Z30_RS19605	COG1024	Enoyl-CoA hydratase
L2Z30_RS19610	COG1024	Enoyl-CoA hydratase
L2Z30_RS19615	COG0477	Major facilitator Superfamily
L2Z30_RS19620	COG3916	Acyl-homoserine-lactone synthase
L2Z30_RS19630	COG2197	response regulator
L2Z30_RS19640	COG1960	acyl-CoA dehydrogenase activity
L2Z30_RS19645	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
L2Z30_RS19645	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Z30_RS19645	COG3321	synthase
L2Z30_RS19645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z30_RS19665	COG2267	carboxylic ester hydrolase activity
L2Z30_RS19685	COG0271	Belongs to the BolA IbaG family
L2Z30_RS19695	COG1192	Involved in chromosome partitioning
L2Z30_RS19710	COG0586	Pfam SNARE associated Golgi protein
L2Z30_RS19715	COG2259	Doxx family
L2Z30_RS19720	COG4399	Belongs to the UPF0754 family
L2Z30_RS19725	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z30_RS19725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z30_RS19770	COG0281	malic enzyme
L2Z30_RS19780	COG2837	iron assimilation
L2Z30_RS19785	COG1280	lysine exporter protein (LysE YggA)
L2Z30_RS19790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Z30_RS19795	COG1121	(ABC) transporter
L2Z30_RS19860	COG0386	Belongs to the glutathione peroxidase family
L2Z30_RS19875	COG1309	transcriptional regulator
L2Z30_RS19880	COG0697	spore germination
L2Z30_RS19890	COG0758	DNA mediated transformation