locus-tag	class	description
L2Z31_RS00040	COG0589	response to stress
L2Z31_RS00045	COG0659	secondary active sulfate transmembrane transporter activity
L2Z31_RS00105	COG0347	Belongs to the P(II) protein family
L2Z31_RS00110	COG0004	ammonium transporteR
L2Z31_RS00120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z31_RS00120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z31_RS00165	COG0795	lipopolysaccharide-transporting ATPase activity
L2Z31_RS00170	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Z31_RS00175	COG0793	Belongs to the peptidase S41A family
L2Z31_RS00190	COG2197	response regulator
L2Z31_RS00200	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2Z31_RS00210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z31_RS00215	COG4974	Belongs to the 'phage' integrase family
L2Z31_RS00240	COG0772	Belongs to the SEDS family
L2Z31_RS00245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z31_RS00250	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Z31_RS00255	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z31_RS00280	COG0697	spore germination
L2Z31_RS00285	COG1538	Outer membrane efflux protein
L2Z31_RS00305	COG3275	phosphorelay sensor kinase activity
L2Z31_RS00315	COG0181	hydroxymethylbilane synthase activity
L2Z31_RS00360	COG1716	ATPase activity
L2Z31_RS00365	COG0546	phosphoglycolate phosphatase activity
L2Z31_RS00460	COG0596	Alpha beta hydrolase
L2Z31_RS00465	COG2056	Na+-H+ antiporter family
L2Z31_RS00480	COG0326	Molecular chaperone. Has ATPase activity
L2Z31_RS00495	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2Z31_RS00560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2Z31_RS00565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z31_RS00565	COG2169	Transcriptional regulator
L2Z31_RS00595	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Z31_RS00605	COG0497	DNA recombination
L2Z31_RS00620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z31_RS00630	COG0237	dephospho-CoA kinase activity
L2Z31_RS00635	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L2Z31_RS00685	COG0195	Participates in both transcription termination and antitermination
L2Z31_RS00700	COG1320	monovalent cation:proton antiporter activity
L2Z31_RS00705	COG2212	antiporter activity
L2Z31_RS00710	COG1863	multisubunit Na H antiporter MnhE subunit
L2Z31_RS00715	COG0651	ATP synthesis coupled electron transport
L2Z31_RS00720	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Z31_RS00725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z31_RS00725	COG2111	Na H antiporter
L2Z31_RS00740	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Z31_RS00745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z31_RS00760	COG2226	methyltransferase
L2Z31_RS00780	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Z31_RS00785	COG1074	ATP-dependent DNA helicase activity
L2Z31_RS00790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z31_RS00795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z31_RS00810	COG0598	Magnesium transport protein CorA
L2Z31_RS00815	COG0789	Transcriptional regulator
L2Z31_RS00820	COG0484	heat shock protein binding
L2Z31_RS00830	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L2Z31_RS00835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z31_RS00835	COG0475	glutathione-regulated potassium exporter activity
L2Z31_RS00840	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Z31_RS00860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z31_RS00870	COG4535	Mg2 and Co2 transporter CorC
L2Z31_RS00875	COG0425	Belongs to the sulfur carrier protein TusA family
L2Z31_RS00880	COG0644	oxidoreductase
L2Z31_RS00880	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2Z31_RS00890	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z31_RS00905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z31_RS00910	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2Z31_RS00950	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Z31_RS00965	COG0534	Mate efflux family protein
L2Z31_RS00975	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z31_RS00980	COG4221	oxidoreductase activity
L2Z31_RS00985	COG0583	DNA-binding transcription factor activity
L2Z31_RS01000	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z31_RS01005	COG1530	ribonuclease E activity
L2Z31_RS01015	COG0546	phosphoglycolate phosphatase activity
L2Z31_RS01020	COG2378	regulation of single-species biofilm formation
L2Z31_RS01025	COG0625	glutathione transferase activity
L2Z31_RS01035	COG0583	DNA-binding transcription factor activity
L2Z31_RS01100	COG0473	3-isopropylmalate dehydrogenase activity
L2Z31_RS01155	COG1301	dicarboxylic acid transport
L2Z31_RS01165	COG1560	Kdo2-lipid A biosynthetic process
L2Z31_RS01170	COG1280	lysine exporter protein (LysE YggA)
L2Z31_RS01175	COG0488	(ABC) transporter
L2Z31_RS01180	COG2900	Belongs to the SlyX family
L2Z31_RS01190	COG1733	regulation of RNA biosynthetic process
L2Z31_RS01215	COG0210	DNA helicase
L2Z31_RS01220	COG0724	RNA recognition motif
L2Z31_RS01240	COG4651	solute:proton antiporter activity
L2Z31_RS01240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z31_RS01265	COG0788	formyltetrahydrofolate deformylase activity
L2Z31_RS01365	COG2813	Specifically methylates the guanine in position
L2Z31_RS01365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z31_RS01375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z31_RS01385	COG4774	siderophore transport
L2Z31_RS01395	COG0740	serine-type endopeptidase activity
L2Z31_RS01415	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z31_RS01415	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z31_RS01420	COG0857	belongs to the CobB CobQ family
L2Z31_RS01420	COG0280	phosphate acetyltransferase
L2Z31_RS01425	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Z31_RS01435	COG0800	Aldolase
L2Z31_RS01445	COG3265	gluconokinase activity
L2Z31_RS01450	COG1012	belongs to the aldehyde dehydrogenase family
L2Z31_RS01460	COG2267	carboxylic ester hydrolase activity
L2Z31_RS01475	COG0793	Belongs to the peptidase S41A family
L2Z31_RS01510	COG1426	Protein conserved in bacteria
L2Z31_RS01555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z31_RS01565	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z31_RS01580	COG2986	histidine ammonia-lyase
L2Z31_RS01620	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z31_RS01625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L2Z31_RS01645	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2Z31_RS01655	COG1162	GTPase activity
L2Z31_RS01660	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Z31_RS01675	COG1538	Outer membrane efflux protein
L2Z31_RS01680	COG1136	(ABC) transporter
L2Z31_RS01680	COG0577	efflux transmembrane transporter activity
L2Z31_RS01685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z31_RS01710	COG0028	Belongs to the TPP enzyme family
L2Z31_RS01715	COG0440	acetolactate synthase activity
L2Z31_RS01745	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Z31_RS01760	COG0084	hydrolase, TatD family'
L2Z31_RS01775	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Z31_RS01785	COG0583	DNA-binding transcription factor activity
L2Z31_RS01795	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z31_RS01800	COG2814	Major facilitator Superfamily
L2Z31_RS01810	COG0697	spore germination
L2Z31_RS01840	COG3622	Belongs to the hyi family
L2Z31_RS01845	COG2084	Dehydrogenase
L2Z31_RS01850	COG1024	Enoyl-CoA hydratase
L2Z31_RS01855	COG5002	protein histidine kinase activity
L2Z31_RS01855	COG0784	Response regulator, receiver
L2Z31_RS01855	COG2205	protein histidine kinase activity
L2Z31_RS01875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z31_RS01885	COG3956	TIGRFAM MazG family protein
L2Z31_RS01890	COG1555	photosystem II stabilization
L2Z31_RS01895	COG0617	tRNA 3'-terminal CCA addition
L2Z31_RS01900	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Z31_RS01920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z31_RS01925	COG3028	Belongs to the UPF0307 family
L2Z31_RS01930	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z31_RS01945	COG0625	glutathione transferase activity
L2Z31_RS01950	COG1238	metal cluster binding
L2Z31_RS01995	COG0072	phenylalanine-tRNA ligase activity
L2Z31_RS02025	COG0248	Ppx GppA phosphatase
L2Z31_RS02035	COG0037	tRNA processing
L2Z31_RS02075	COG1764	response to oxidative stress
L2Z31_RS02080	COG1846	Transcriptional regulator
L2Z31_RS02090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z31_RS02150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2Z31_RS02155	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Z31_RS02160	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Z31_RS02220	COG1214	PFAM Peptidase M22, glycoprotease
L2Z31_RS02245	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z31_RS02250	COG0561	phosphatase activity
L2Z31_RS02260	COG2132	Multicopper oxidase
L2Z31_RS02265	COG3667	copper resistance
L2Z31_RS02280	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z31_RS02285	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Z31_RS02290	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Z31_RS02320	COG1063	alcohol dehydrogenase
L2Z31_RS02325	COG0583	DNA-binding transcription factor activity
L2Z31_RS02330	COG1960	acyl-CoA dehydrogenase activity
L2Z31_RS02335	COG2814	Major facilitator Superfamily
L2Z31_RS02340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z31_RS02350	COG1053	succinate dehydrogenase
L2Z31_RS02355	COG0583	DNA-binding transcription factor activity
L2Z31_RS02370	COG0583	DNA-binding transcription factor activity
L2Z31_RS02400	COG0583	DNA-binding transcription factor activity
L2Z31_RS02415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z31_RS02435	COG0384	phenazine biosynthesis protein PhzF
L2Z31_RS02455	COG4993	Dehydrogenase
L2Z31_RS02525	COG2205	protein histidine kinase activity
L2Z31_RS02535	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Z31_RS02555	COG0745	RESPONSE REGULATOR receiver
L2Z31_RS02595	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Z31_RS02625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z31_RS02630	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Z31_RS02650	COG0583	DNA-binding transcription factor activity
L2Z31_RS02670	COG0668	transmembrane transport
L2Z31_RS02680	COG2081	HI0933 family
L2Z31_RS02685	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z31_RS02715	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z31_RS02715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z31_RS02725	COG0489	protein tyrosine kinase activity
L2Z31_RS02775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z31_RS02785	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Z31_RS02800	COG0730	response to heat
L2Z31_RS02810	COG1196	nuclear chromosome segregation
L2Z31_RS02830	COG2223	nitrite transmembrane transporter activity
L2Z31_RS02835	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2Z31_RS02840	COG1877	trehalose-phosphatase activity
L2Z31_RS02845	COG0596	Alpha beta hydrolase
L2Z31_RS02845	COG2226	methyltransferase
L2Z31_RS02845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z31_RS02860	COG4106	trans-aconitate 2-methyltransferase activity
L2Z31_RS02875	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Z31_RS02880	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2Z31_RS02885	COG0009	L-threonylcarbamoyladenylate synthase
L2Z31_RS02890	COG3101	peptidyl-lysine hydroxylation
L2Z31_RS02895	COG1399	metal-binding, possibly nucleic acid-binding protein
L2Z31_RS02920	COG1652	LysM domain
L2Z31_RS02925	COG0351	phosphomethylpyrimidine kinase
L2Z31_RS02925	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z31_RS02925	COG0352	thiamine-phosphate diphosphorylase activity
L2Z31_RS02935	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2Z31_RS02965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z31_RS02995	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Z31_RS03010	COG0358	DNA primase activity
L2Z31_RS03020	COG0564	pseudouridine synthase activity
L2Z31_RS03045	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z31_RS03065	COG0583	DNA-binding transcription factor activity
L2Z31_RS03070	COG0473	3-isopropylmalate dehydrogenase activity
L2Z31_RS03090	COG0657	acetylesterase activity
L2Z31_RS03100	COG1012	belongs to the aldehyde dehydrogenase family
L2Z31_RS03120	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Z31_RS03120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z31_RS03135	COG1981	membrane
L2Z31_RS03180	COG0456	acetyltransferase
L2Z31_RS03190	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Z31_RS03195	COG0492	ferredoxin-NADP+ reductase activity
L2Z31_RS03200	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Z31_RS03200	COG1674	ftsk spoiiie
L2Z31_RS03205	COG1280	lysine exporter protein (LysE YggA)
L2Z31_RS03225	COG2894	cell division
L2Z31_RS03240	COG0204	Acyl-transferase
L2Z31_RS03245	COG2885	chlorophyll binding
L2Z31_RS03250	COG0210	DNA helicase
L2Z31_RS03260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z31_RS03275	COG0121	glutamine amidotransferase
L2Z31_RS03295	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z31_RS03300	COG0735	belongs to the Fur family
L2Z31_RS03325	COG0420	3'-5' exonuclease activity
L2Z31_RS03345	COG1090	epimerase
L2Z31_RS03360	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z31_RS03370	COG2814	Major facilitator Superfamily
L2Z31_RS03375	COG0405	Gamma-glutamyltransferase
L2Z31_RS03415	COG0477	Major facilitator Superfamily
L2Z31_RS03420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z31_RS03445	COG0531	amino acid
L2Z31_RS03450	COG2040	homocysteine
L2Z31_RS03475	COG1309	transcriptional regulator
L2Z31_RS03480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z31_RS03485	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z31_RS03495	COG1607	acyl-coa hydrolase
L2Z31_RS03505	COG0523	cobalamin synthesis protein
L2Z31_RS03515	COG4681	YaeQ
L2Z31_RS03525	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z31_RS03525	COG0726	polysaccharide deacetylase
L2Z31_RS03530	COG1215	transferase activity, transferring glycosyl groups
L2Z31_RS03540	COG1024	Enoyl-CoA hydratase
L2Z31_RS03555	COG1414	Transcriptional regulator
L2Z31_RS03575	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z31_RS03585	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z31_RS03590	COG2271	Major facilitator Superfamily
L2Z31_RS03600	COG2267	carboxylic ester hydrolase activity
L2Z31_RS03605	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z31_RS03620	COG0028	Belongs to the TPP enzyme family
L2Z31_RS03630	COG0477	Major facilitator Superfamily
L2Z31_RS03635	COG0242	peptide deformylase activity
L2Z31_RS03640	COG2066	Belongs to the glutaminase family
L2Z31_RS03645	COG2207	Transcriptional regulator
L2Z31_RS03650	COG2223	nitrite transmembrane transporter activity
L2Z31_RS03665	COG0583	DNA-binding transcription factor activity
L2Z31_RS03670	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z31_RS03675	COG2271	Major facilitator Superfamily
L2Z31_RS03680	COG3959	Transketolase, thiamine diphosphate binding domain
L2Z31_RS03685	COG3958	Transketolase
L2Z31_RS03695	COG0306	phosphate transporter
L2Z31_RS03715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z31_RS03760	COG4181	ATPase activity
L2Z31_RS03765	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Z31_RS03790	COG0583	DNA-binding transcription factor activity
L2Z31_RS03800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z31_RS03805	COG1773	rubredoxin
L2Z31_RS03910	COG0488	(ABC) transporter
L2Z31_RS03915	COG3173	Aminoglycoside phosphotransferase
L2Z31_RS03925	COG2433	Pfam Transposase IS66
L2Z31_RS03950	COG1301	dicarboxylic acid transport
L2Z31_RS03960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z31_RS03965	COG2011	ABC-type metal ion transport system permease component
L2Z31_RS03970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z31_RS03975	COG1464	Belongs to the NlpA lipoprotein family
L2Z31_RS03980	COG0151	Belongs to the GarS family
L2Z31_RS03985	COG0138	bifunctional purine biosynthesis protein purh
L2Z31_RS03990	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Z31_RS04020	COG2308	Evidence 4 Homologs of previously reported genes of
L2Z31_RS04030	COG1305	Transglutaminase-like
L2Z31_RS04040	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Z31_RS04045	COG0305	Participates in initiation and elongation during chromosome replication
L2Z31_RS04070	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2Z31_RS04080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Z31_RS04085	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Z31_RS04110	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z31_RS04110	COG0726	polysaccharide deacetylase
L2Z31_RS04115	COG1215	transferase activity, transferring glycosyl groups
L2Z31_RS04120	COG3658	cytochrome
L2Z31_RS04130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z31_RS04145	COG0583	DNA-binding transcription factor activity
L2Z31_RS04165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z31_RS04170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z31_RS04185	COG1960	acyl-CoA dehydrogenase activity
L2Z31_RS04190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z31_RS04195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z31_RS04220	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2Z31_RS04225	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2Z31_RS04235	COG2205	protein histidine kinase activity
L2Z31_RS04240	COG0745	RESPONSE REGULATOR receiver
L2Z31_RS04245	COG0174	glutamine synthetase
L2Z31_RS04265	COG0729	surface antigen
L2Z31_RS04290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z31_RS04295	COG2814	Major facilitator Superfamily
L2Z31_RS04310	COG0583	DNA-binding transcription factor activity
L2Z31_RS04325	COG1187	pseudouridine synthase activity
L2Z31_RS04345	COG0802	atpase or kinase
L2Z31_RS04350	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Z31_RS04360	COG1923	regulation of RNA biosynthetic process
L2Z31_RS04365	COG0697	spore germination
L2Z31_RS04380	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z31_RS04390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z31_RS04395	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z31_RS04395	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z31_RS04400	COG4302	ethanolamine ammonia-lyase activity
L2Z31_RS04405	COG4303	Ethanolamine ammonia lyase large subunit
L2Z31_RS04410	COG0531	amino acid
L2Z31_RS04430	COG1454	alcohol dehydrogenase
L2Z31_RS04435	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z31_RS04445	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
L2Z31_RS04465	COG0308	aminopeptidase N
L2Z31_RS04475	COG4221	oxidoreductase activity
L2Z31_RS04485	COG1605	Chorismate mutase
L2Z31_RS04505	COG1309	transcriptional regulator
L2Z31_RS04515	COG0668	transmembrane transport
L2Z31_RS04550	COG4773	Receptor
L2Z31_RS04570	COG0488	(ABC) transporter
L2Z31_RS04575	COG0589	response to stress
L2Z31_RS04600	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Z31_RS04610	COG3135	benzoate transporter
L2Z31_RS04615	COG1522	sequence-specific DNA binding
L2Z31_RS04625	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z31_RS04630	COG0583	DNA-binding transcription factor activity
L2Z31_RS04640	COG0183	Belongs to the thiolase family
L2Z31_RS04650	COG2030	dehydratase
L2Z31_RS04655	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z31_RS04670	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z31_RS04680	COG0824	Thioesterase
L2Z31_RS04685	COG1454	alcohol dehydrogenase
L2Z31_RS04695	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Z31_RS04715	COG0069	glutamate synthase activity
L2Z31_RS04775	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z31_RS04865	COG1484	DNA-dependent DNA replication
L2Z31_RS05060	COG2026	Addiction module toxin, RelE StbE family
L2Z31_RS05100	COG0592	DNA-directed DNA polymerase activity
L2Z31_RS05220	COG2814	Major facilitator Superfamily
L2Z31_RS05235	COG0511	ligase activity, forming carbon-carbon bonds
L2Z31_RS05255	COG1116	anion transmembrane transporter activity
L2Z31_RS05255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z31_RS05260	COG0745	RESPONSE REGULATOR receiver
L2Z31_RS05270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z31_RS05270	COG2146	nitrite reductase [NAD(P)H] activity
L2Z31_RS05275	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z31_RS05280	COG0243	molybdopterin cofactor binding
L2Z31_RS05290	COG0243	molybdopterin cofactor binding
L2Z31_RS05295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Z31_RS05310	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Z31_RS05310	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Z31_RS05315	COG0303	'Molybdopterin
L2Z31_RS05325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z31_RS05330	COG0697	spore germination
L2Z31_RS05350	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Z31_RS05355	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z31_RS05410	COG2204	response regulator
L2Z31_RS05415	COG3852	Histidine kinase
L2Z31_RS05435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Z31_RS05440	COG0575	Belongs to the CDS family
L2Z31_RS05475	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z31_RS05490	COG2137	regulation of response to DNA damage stimulus
L2Z31_RS05500	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Z31_RS05505	COG1011	Hydrolase
L2Z31_RS05530	COG1522	sequence-specific DNA binding
L2Z31_RS05540	COG1113	amino acid transport
L2Z31_RS05560	COG0659	secondary active sulfate transmembrane transporter activity
L2Z31_RS05565	COG2135	peptidase activity
L2Z31_RS05580	COG3300	MHYT domain
L2Z31_RS05580	COG5001	Diguanylate cyclase
L2Z31_RS05600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z31_RS05600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z31_RS05600	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2Z31_RS05605	COG1105	Belongs to the carbohydrate kinase PfkB family
L2Z31_RS05610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Z31_RS05610	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z31_RS05640	COG0024	Methionine aminopeptidase
L2Z31_RS05645	COG0583	DNA-binding transcription factor activity
L2Z31_RS05655	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Z31_RS05660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z31_RS05665	COG0517	IMP dehydrogenase activity
L2Z31_RS05665	COG0516	GMP reductase activity
L2Z31_RS05690	COG0552	protein localization to endoplasmic reticulum
L2Z31_RS05700	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2Z31_RS05715	COG4890	Cyd operon protein YbgT
L2Z31_RS05720	COG1294	oxidase, subunit
L2Z31_RS05740	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2Z31_RS05750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Z31_RS05755	COG4774	siderophore transport
L2Z31_RS05770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Z31_RS05775	COG0569	domain protein
L2Z31_RS05780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z31_RS05810	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Z31_RS05815	COG0542	response to heat
L2Z31_RS05840	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z31_RS05840	COG1902	pentaerythritol trinitrate reductase activity
L2Z31_RS05885	COG2323	membrane
L2Z31_RS05890	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Z31_RS05900	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z31_RS05905	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z31_RS05910	COG0183	Belongs to the thiolase family
L2Z31_RS05915	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Z31_RS05920	COG0596	Alpha beta hydrolase
L2Z31_RS05925	COG2271	Major facilitator Superfamily
L2Z31_RS05930	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z31_RS05935	COG3485	protocatechuate 3,4-dioxygenase
L2Z31_RS05940	COG3485	protocatechuate 3,4-dioxygenase
L2Z31_RS05945	COG0710	3-dehydroquinate dehydratase activity
L2Z31_RS05950	COG3420	alginic acid biosynthetic process
L2Z31_RS05955	COG3659	wide pore channel activity
L2Z31_RS05960	COG4993	Dehydrogenase
L2Z31_RS05970	COG2391	methyltransferase activity
L2Z31_RS05985	COG1414	Transcriptional regulator
L2Z31_RS05990	COG0583	DNA-binding transcription factor activity
L2Z31_RS05995	COG1960	acyl-CoA dehydrogenase activity
L2Z31_RS06020	COG2814	Major facilitator Superfamily
L2Z31_RS06030	COG0154	amidase activity
L2Z31_RS06050	COG4638	Rieske (2fe-2S)
L2Z31_RS06060	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z31_RS06070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z31_RS06080	COG3733	amine oxidase
L2Z31_RS06090	COG1012	belongs to the aldehyde dehydrogenase family
L2Z31_RS06100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z31_RS06105	COG0183	Belongs to the thiolase family
L2Z31_RS06110	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z31_RS06115	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z31_RS06125	COG4829	muconolactone delta-isomerase
L2Z31_RS06130	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z31_RS06135	COG0583	DNA-binding transcription factor activity
L2Z31_RS06145	COG2186	Transcriptional regulator
L2Z31_RS06165	COG1012	belongs to the aldehyde dehydrogenase family
L2Z31_RS06185	COG1960	acyl-CoA dehydrogenase activity
L2Z31_RS06190	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z31_RS06205	COG3162	membrane
L2Z31_RS06220	COG1012	belongs to the aldehyde dehydrogenase family
L2Z31_RS06235	COG0753	catalase activity
L2Z31_RS06255	COG1846	Transcriptional regulator
L2Z31_RS06260	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z31_RS06260	COG1902	pentaerythritol trinitrate reductase activity
L2Z31_RS06270	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L2Z31_RS06300	COG1309	transcriptional regulator
L2Z31_RS06310	COG1335	isochorismatase
L2Z31_RS06315	COG0583	DNA-binding transcription factor activity
L2Z31_RS06325	COG0475	glutathione-regulated potassium exporter activity
L2Z31_RS06325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z31_RS06335	COG1473	amidohydrolase
L2Z31_RS06345	COG2831	hemolysin activation secretion protein
L2Z31_RS06390	COG2188	Transcriptional regulator
L2Z31_RS06405	COG0583	DNA-binding transcription factor activity
L2Z31_RS06435	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z31_RS06465	COG1566	PFAM secretion protein HlyD family protein
L2Z31_RS06480	COG1012	belongs to the aldehyde dehydrogenase family
L2Z31_RS06485	COG0129	dihydroxy-acid dehydratase activity
L2Z31_RS06495	COG0583	DNA-binding transcription factor activity
L2Z31_RS06500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z31_RS06510	COG2084	Dehydrogenase
L2Z31_RS06515	COG2207	Transcriptional regulator
L2Z31_RS06530	COG1064	alcohol dehydrogenase
L2Z31_RS06540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z31_RS06545	COG1120	ATPase activity
L2Z31_RS06565	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z31_RS06685	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2Z31_RS06735	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z31_RS06750	COG2207	Transcriptional regulator
L2Z31_RS06760	COG2205	protein histidine kinase activity
L2Z31_RS06765	COG0745	RESPONSE REGULATOR receiver
L2Z31_RS06775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z31_RS06780	COG1538	Outer membrane efflux protein
L2Z31_RS06790	COG2072	flavoprotein involved in K transport
L2Z31_RS06810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z31_RS06830	COG3539	Fimbrial protein
L2Z31_RS06860	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L2Z31_RS06870	COG0753	catalase activity
L2Z31_RS06885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z31_RS06945	COG3433	isochorismatase activity
L2Z31_RS06945	COG1535	isochorismatase
L2Z31_RS06950	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z31_RS06955	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2Z31_RS06960	COG4149	molybdate abc transporter
L2Z31_RS06965	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2Z31_RS06975	COG4638	Rieske (2fe-2S)
L2Z31_RS06980	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z31_RS06985	COG0543	2 iron, 2 sulfur cluster binding
L2Z31_RS06985	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z31_RS07010	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z31_RS07025	COG2207	Transcriptional regulator
L2Z31_RS07035	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z31_RS07040	COG2610	gluconate transmembrane transporter activity
L2Z31_RS07050	COG0583	DNA-binding transcription factor activity
L2Z31_RS07060	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z31_RS07065	COG2031	fatty acid transporter
L2Z31_RS07070	COG0183	Belongs to the thiolase family
L2Z31_RS07075	COG0583	DNA-binding transcription factor activity
L2Z31_RS07080	COG0583	DNA-binding transcription factor activity
L2Z31_RS07095	COG1027	Aspartate ammonia-lyase
L2Z31_RS07105	COG0477	Major facilitator Superfamily
L2Z31_RS07125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z31_RS07130	COG4521	taurine ABC transporter
L2Z31_RS07145	COG2188	Transcriptional regulator
L2Z31_RS07155	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Z31_RS07160	COG1733	regulation of RNA biosynthetic process
L2Z31_RS07165	COG3708	Transcriptional regulator
L2Z31_RS07165	COG2207	Transcriptional regulator
L2Z31_RS07180	COG0730	response to heat
L2Z31_RS07195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z31_RS07195	COG3453	Protein conserved in bacteria
L2Z31_RS07205	COG3781	membrane
L2Z31_RS07210	COG1063	alcohol dehydrogenase
L2Z31_RS07220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z31_RS07225	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z31_RS07230	COG0022	dehydrogenase e1 component
L2Z31_RS07235	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2Z31_RS07240	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z31_RS07255	COG3706	GGDEF domain
L2Z31_RS07270	COG0133	tryptophan synthase activity
L2Z31_RS07280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z31_RS07315	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Z31_RS07340	COG2226	methyltransferase
L2Z31_RS07395	COG0842	Transport permease protein
L2Z31_RS07400	COG0842	Transport permease protein
L2Z31_RS07405	COG1131	(ABC) transporter
L2Z31_RS07420	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z31_RS07425	COG4773	Receptor
L2Z31_RS07445	COG0730	response to heat
L2Z31_RS07450	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Z31_RS07470	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2Z31_RS07485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z31_RS07525	COG4264	IucA IucC family
L2Z31_RS07530	COG4264	IucA IucC family
L2Z31_RS07550	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Z31_RS07565	COG1960	acyl-CoA dehydrogenase activity
L2Z31_RS07570	COG1960	acyl-CoA dehydrogenase activity
L2Z31_RS07575	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z31_RS07580	COG2207	Transcriptional regulator
L2Z31_RS07585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z31_RS07590	COG0776	regulation of translation
L2Z31_RS07615	COG0822	iron-sulfur transferase activity
L2Z31_RS07620	COG0316	Belongs to the HesB IscA family
L2Z31_RS07650	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Z31_RS07670	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z31_RS07675	COG0702	epimerase
L2Z31_RS07710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Z31_RS07720	COG0339	signal peptide processing
L2Z31_RS07770	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Z31_RS07775	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Z31_RS07805	COG0776	regulation of translation
L2Z31_RS07870	COG0084	hydrolase, TatD family'
L2Z31_RS07890	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Z31_RS07895	COG1132	(ABC) transporter
L2Z31_RS07905	COG0811	peptide transport
L2Z31_RS07910	COG1475	DNA binding
L2Z31_RS07915	COG1192	Involved in chromosome partitioning
L2Z31_RS07925	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z31_RS07940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z31_RS07945	COG0191	fructose-bisphosphate aldolase activity
L2Z31_RS07965	COG0424	maF-like protein
L2Z31_RS07970	COG2850	peptidyl-arginine hydroxylation
L2Z31_RS07980	COG0640	Transcriptional regulator
L2Z31_RS07990	COG3619	membrane
L2Z31_RS07995	COG3122	Protein conserved in bacteria
L2Z31_RS08000	COG1132	(ABC) transporter
L2Z31_RS08020	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Z31_RS08025	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z31_RS08035	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z31_RS08035	COG0506	proline dehydrogenase activity
L2Z31_RS08035	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z31_RS08040	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2Z31_RS08055	COG3698	Phosphodiester glycosidase
L2Z31_RS08065	COG2353	YceI-like domain
L2Z31_RS08075	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Z31_RS08120	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Z31_RS08120	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Z31_RS08145	COG3539	Fimbrial protein
L2Z31_RS08150	COG3121	Chaperone
L2Z31_RS08175	COG0697	spore germination
L2Z31_RS08185	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z31_RS08195	COG0583	DNA-binding transcription factor activity
L2Z31_RS08215	COG1309	transcriptional regulator
L2Z31_RS08230	COG1522	sequence-specific DNA binding
L2Z31_RS08240	COG1126	abc transporter atp-binding protein
L2Z31_RS08245	COG0765	amino acid transport
L2Z31_RS08250	COG0765	amino acid transport
L2Z31_RS08280	COG1464	Belongs to the NlpA lipoprotein family
L2Z31_RS08290	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z31_RS08295	COG2011	ABC-type metal ion transport system permease component
L2Z31_RS08300	COG0012	GTP binding
L2Z31_RS08325	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z31_RS08365	COG0386	Belongs to the glutathione peroxidase family
L2Z31_RS08375	COG0436	Aminotransferase
L2Z31_RS08415	COG3634	alkyl hydroperoxide reductase activity
L2Z31_RS08430	COG0583	DNA-binding transcription factor activity
L2Z31_RS08435	COG0798	PFAM Bile acid sodium symporter
L2Z31_RS08440	COG0640	Transcriptional regulator
L2Z31_RS08475	COG0583	DNA-binding transcription factor activity
L2Z31_RS08485	COG1953	Uracil, thiamine, allantoin
L2Z31_RS08495	COG2175	clavaminate synthase activity
L2Z31_RS08500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z31_RS08505	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2Z31_RS08510	COG4521	taurine ABC transporter
L2Z31_RS08520	COG0477	Major facilitator Superfamily
L2Z31_RS08540	COG1271	oxidase subunit
L2Z31_RS08545	COG1294	oxidase, subunit
L2Z31_RS08555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z31_RS08575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Z31_RS08595	COG3052	prosthetic group binding
L2Z31_RS08600	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2Z31_RS08610	COG2814	Major facilitator Superfamily
L2Z31_RS08630	COG1346	cytolysis
L2Z31_RS08640	COG0583	DNA-binding transcription factor activity
L2Z31_RS08645	COG0625	glutathione transferase activity
L2Z31_RS08650	COG0625	glutathione transferase activity
L2Z31_RS08655	COG0583	DNA-binding transcription factor activity
L2Z31_RS08670	COG1045	serine acetyltransferase
L2Z31_RS08675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z31_RS08680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2Z31_RS08690	COG1280	lysine exporter protein (LysE YggA)
L2Z31_RS08705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z31_RS08710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z31_RS08715	COG1126	abc transporter atp-binding protein
L2Z31_RS08720	COG0765	amino acid transport
L2Z31_RS08725	COG0765	amino acid transport
L2Z31_RS08745	COG0784	Response regulator, receiver
L2Z31_RS08745	COG2205	protein histidine kinase activity
L2Z31_RS08765	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Z31_RS08785	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z31_RS08835	COG0583	DNA-binding transcription factor activity
L2Z31_RS08855	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z31_RS08860	COG1309	transcriptional regulator
L2Z31_RS08865	COG1960	acyl-CoA dehydrogenase activity
L2Z31_RS08870	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z31_RS08875	COG1024	Enoyl-CoA hydratase
L2Z31_RS08880	COG4770	biotin carboxylase activity
L2Z31_RS08890	COG0583	DNA-binding transcription factor activity
L2Z31_RS08905	COG1960	acyl-CoA dehydrogenase activity
L2Z31_RS08915	COG2814	Major facilitator Superfamily
L2Z31_RS08925	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z31_RS08930	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z31_RS08935	COG2814	Major facilitator Superfamily
L2Z31_RS08940	COG1960	acyl-CoA dehydrogenase activity
L2Z31_RS08945	COG1024	Enoyl-CoA hydratase
L2Z31_RS08950	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z31_RS08955	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z31_RS08960	COG0183	Belongs to the thiolase family
L2Z31_RS08970	COG2814	Major facilitator Superfamily
L2Z31_RS08980	COG1024	Enoyl-CoA hydratase
L2Z31_RS08995	COG1960	acyl-CoA dehydrogenase activity
L2Z31_RS09000	COG2814	Major facilitator Superfamily
L2Z31_RS09005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z31_RS09010	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Z31_RS09025	COG3842	ATPase activity
L2Z31_RS09030	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Z31_RS09040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z31_RS09045	COG1414	Transcriptional regulator
L2Z31_RS09055	COG0583	DNA-binding transcription factor activity
L2Z31_RS09060	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z31_RS09065	COG1012	belongs to the aldehyde dehydrogenase family
L2Z31_RS09075	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z31_RS09085	COG1012	belongs to the aldehyde dehydrogenase family
L2Z31_RS09090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z31_RS09095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z31_RS09100	COG2267	carboxylic ester hydrolase activity
L2Z31_RS09120	COG3038	cytochrome b561
L2Z31_RS09125	COG0753	catalase activity
L2Z31_RS09160	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z31_RS09170	COG3327	negative regulation of DNA-templated transcription, initiation
L2Z31_RS09175	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L2Z31_RS09180	COG0183	Belongs to the thiolase family
L2Z31_RS09185	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z31_RS09190	COG1024	Enoyl-CoA hydratase
L2Z31_RS09195	COG1024	Enoyl-CoA hydratase
L2Z31_RS09200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z31_RS09205	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Z31_RS09210	COG3396	Phenylacetate-CoA oxygenase
L2Z31_RS09215	COG3460	Phenylacetate-CoA oxygenase
L2Z31_RS09220	COG3396	Phenylacetate-CoA oxygenase
L2Z31_RS09225	COG1012	belongs to the aldehyde dehydrogenase family
L2Z31_RS09225	COG2030	dehydratase
L2Z31_RS09230	COG1760	l-serine dehydratase
L2Z31_RS09235	COG0531	amino acid
L2Z31_RS09240	COG1012	belongs to the aldehyde dehydrogenase family
L2Z31_RS09255	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z31_RS09265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z31_RS09285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z31_RS09295	COG0789	Transcriptional regulator
L2Z31_RS09310	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2Z31_RS09325	COG2807	transmembrane transport
L2Z31_RS09330	COG0590	tRNA wobble adenosine to inosine editing
L2Z31_RS09450	COG1116	anion transmembrane transporter activity
L2Z31_RS09455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z31_RS09465	COG0864	Transcriptional regulator
L2Z31_RS09485	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z31_RS09490	COG0439	Biotin carboxylase
L2Z31_RS09505	COG1063	alcohol dehydrogenase
L2Z31_RS09515	COG1309	transcriptional regulator
L2Z31_RS09535	COG0038	chloride channel
L2Z31_RS09540	COG4770	biotin carboxylase activity
L2Z31_RS09560	COG1914	H( )-stimulated, divalent metal cation uptake system
L2Z31_RS09565	COG0583	DNA-binding transcription factor activity
L2Z31_RS09615	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z31_RS09635	COG2814	Major facilitator Superfamily
L2Z31_RS09650	COG1560	Kdo2-lipid A biosynthetic process
L2Z31_RS09660	COG5006	permease, DMT superfamily
L2Z31_RS09665	COG1522	sequence-specific DNA binding
L2Z31_RS09680	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2Z31_RS09690	COG4122	O-methyltransferase activity
L2Z31_RS09720	COG1538	Outer membrane efflux protein
L2Z31_RS09725	COG1137	ATPase activity
L2Z31_RS09730	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2Z31_RS09740	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Z31_RS09745	COG0517	IMP dehydrogenase activity
L2Z31_RS09745	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L2Z31_RS09780	COG2814	Major facilitator Superfamily
L2Z31_RS09815	COG1278	Cold shock
L2Z31_RS09820	COG1280	lysine exporter protein (LysE YggA)
L2Z31_RS09850	COG1570	exodeoxyribonuclease VII activity
L2Z31_RS09900	COG0583	DNA-binding transcription factor activity
L2Z31_RS09910	COG4638	Rieske (2fe-2S)
L2Z31_RS09915	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z31_RS09920	COG0543	2 iron, 2 sulfur cluster binding
L2Z31_RS09920	COG0633	Ferredoxin
L2Z31_RS09925	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z31_RS09930	COG3135	benzoate transporter
L2Z31_RS09935	COG2814	Major facilitator Superfamily
L2Z31_RS09950	COG1643	Atp-dependent helicase
L2Z31_RS09955	COG0450	alkyl hydroperoxide reductase
L2Z31_RS09965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2Z31_RS09975	COG3634	alkyl hydroperoxide reductase activity
L2Z31_RS09995	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2Z31_RS10000	COG0625	glutathione transferase activity
L2Z31_RS10010	COG2885	chlorophyll binding
L2Z31_RS10045	COG0542	response to heat
L2Z31_RS10060	COG1765	OsmC-like protein
L2Z31_RS10080	COG0667	Aldo Keto reductase
L2Z31_RS10095	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Z31_RS10105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Z31_RS10115	COG0527	aspartate kinase activity
L2Z31_RS10125	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2Z31_RS10135	COG3038	cytochrome b561
L2Z31_RS10140	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2Z31_RS10145	COG2252	PERMEase
L2Z31_RS10165	COG4269	membrane
L2Z31_RS10180	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z31_RS10180	COG1902	pentaerythritol trinitrate reductase activity
L2Z31_RS10190	COG3706	GGDEF domain
L2Z31_RS10190	COG2203	Gaf domain
L2Z31_RS10190	COG5001	Diguanylate cyclase
L2Z31_RS10190	COG4251	negative regulation of phosphorylation
L2Z31_RS10200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z31_RS10220	COG4172	Belongs to the ABC transporter superfamily
L2Z31_RS10225	COG4239	(ABC) transporter, permease
L2Z31_RS10230	COG4174	ABC transporter (Permease)
L2Z31_RS10240	COG0741	lytic transglycosylase activity
L2Z31_RS10240	COG1388	LysM domain
L2Z31_RS10240	COG0741	lytic transglycosylase activity
L2Z31_RS10240	COG1388	LysM domain
L2Z31_RS10245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z31_RS10285	COG0583	DNA-binding transcription factor activity
L2Z31_RS10290	COG1279	arginine transmembrane transporter activity
L2Z31_RS10310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z31_RS10315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z31_RS10320	COG0006	proline dipeptidase activity
L2Z31_RS10360	COG2194	sulfuric ester hydrolase activity
L2Z31_RS10405	COG0739	heme binding
L2Z31_RS10730	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2Z31_RS10755	COG3384	dioxygenase
L2Z31_RS10765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z31_RS10770	COG2878	Part of a membrane complex involved in electron transport
L2Z31_RS10775	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Z31_RS10800	COG0768	penicillin binding
L2Z31_RS10805	COG0742	ribosomal rna small subunit methyltransferase
L2Z31_RS10820	COG0830	nickel cation binding
L2Z31_RS10830	COG0804	urea catabolic process
L2Z31_RS10870	COG1253	flavin adenine dinucleotide binding
L2Z31_RS10875	COG2851	Citrate transporter
L2Z31_RS10920	COG1794	racemase activity, acting on amino acids and derivatives
L2Z31_RS10930	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Z31_RS10930	COG3008	intermembrane lipid transfer
L2Z31_RS10935	COG2995	paraquat-inducible protein a
L2Z31_RS10945	COG2985	domain, Protein
L2Z31_RS10975	COG0477	Major facilitator Superfamily
L2Z31_RS11025	COG2186	Transcriptional regulator
L2Z31_RS11035	COG0786	glutamate:sodium symporter activity
L2Z31_RS11040	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Z31_RS11065	COG3111	PFAM Bacterial OB fold (BOF) protein
L2Z31_RS11165	COG1610	YqeY-like protein
L2Z31_RS11170	COG4783	chaperone-mediated protein folding
L2Z31_RS11195	COG1286	toxin biosynthetic process
L2Z31_RS11225	COG0778	Nitroreductase
L2Z31_RS11235	COG0513	Belongs to the DEAD box helicase family
L2Z31_RS11260	COG2363	Small membrane protein
L2Z31_RS11290	COG1234	tRNA 3'-trailer cleavage
L2Z31_RS11295	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2Z31_RS11305	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Z31_RS11315	COG2819	hydrolase of the alpha beta superfamily
L2Z31_RS11320	COG1960	acyl-CoA dehydrogenase activity
L2Z31_RS11325	COG1301	dicarboxylic acid transport
L2Z31_RS11330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Z31_RS11335	COG3139	Protein of unknown function (DUF1315)
L2Z31_RS11340	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Z31_RS11345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Z31_RS11355	COG0494	nUDIX hydrolase
L2Z31_RS11365	COG0642	Histidine kinase
L2Z31_RS11380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Z31_RS11390	COG1720	tRNA m6t6A37 methyltransferase activity
L2Z31_RS11405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z31_RS11410	COG0826	peptidase U32
L2Z31_RS11415	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z31_RS11425	COG4598	ABC transporter
L2Z31_RS11430	COG4160	amino acid transport
L2Z31_RS11435	COG4215	(ABC) transporter
L2Z31_RS11450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z31_RS11495	COG1131	(ABC) transporter
L2Z31_RS11500	COG0842	Transport permease protein
L2Z31_RS11515	COG0772	Belongs to the SEDS family
L2Z31_RS11520	COG2951	lytic endotransglycosylase activity
L2Z31_RS11545	COG2207	Transcriptional regulator
L2Z31_RS11560	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Z31_RS11565	COG0024	Methionine aminopeptidase
L2Z31_RS11575	COG2223	nitrite transmembrane transporter activity
L2Z31_RS11585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z31_RS11590	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z31_RS11595	COG1960	acyl-CoA dehydrogenase activity
L2Z31_RS11610	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Z31_RS11615	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Z31_RS11620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z31_RS11640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z31_RS11645	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2Z31_RS11650	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Z31_RS11685	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Z31_RS11695	COG0174	glutamine synthetase
L2Z31_RS11710	COG0512	Glutamine amidotransferase of anthranilate synthase
L2Z31_RS11715	COG0308	aminopeptidase N
L2Z31_RS11745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2Z31_RS11755	COG0302	gtp cyclohydrolase
L2Z31_RS11780	COG3739	integral membrane protein
L2Z31_RS11795	COG1169	isochorismate synthase
L2Z31_RS11805	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z31_RS11810	COG1132	(ABC) transporter
L2Z31_RS11815	COG1132	(ABC) transporter
L2Z31_RS11830	COG3433	isochorismatase activity
L2Z31_RS11830	COG1535	isochorismatase
L2Z31_RS11835	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z31_RS11840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z31_RS11850	COG4774	siderophore transport
L2Z31_RS11855	COG4607	ABC-type enterochelin transport system periplasmic component
L2Z31_RS11860	COG4604	ABC transporter, ATP-binding protein
L2Z31_RS11865	COG4605	iron ion homeostasis
L2Z31_RS11870	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z31_RS11875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z31_RS11890	COG2964	Protein conserved in bacteria
L2Z31_RS11900	COG1741	Belongs to the pirin family
L2Z31_RS11920	COG1309	transcriptional regulator
L2Z31_RS11930	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z31_RS11935	COG2814	Major facilitator Superfamily
L2Z31_RS11970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z31_RS11970	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2Z31_RS11975	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z31_RS11985	COG1012	belongs to the aldehyde dehydrogenase family
L2Z31_RS11995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z31_RS12000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z31_RS12005	COG0583	DNA-binding transcription factor activity
L2Z31_RS12010	COG1113	amino acid transport
L2Z31_RS12030	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L2Z31_RS12030	COG2508	Transcriptional regulator
L2Z31_RS12065	COG2879	small protein
L2Z31_RS12070	COG1966	Carbon starvation protein
L2Z31_RS12115	COG1067	ATP-dependent peptidase activity
L2Z31_RS12120	COG0583	DNA-binding transcription factor activity
L2Z31_RS12145	COG1686	Belongs to the peptidase S11 family
L2Z31_RS12150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Z31_RS12200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Z31_RS12210	COG0573	inorganic phosphate transmembrane transporter activity
L2Z31_RS12215	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Z31_RS12220	COG1113	amino acid transport
L2Z31_RS12225	COG3961	Belongs to the TPP enzyme family
L2Z31_RS12230	COG1522	sequence-specific DNA binding
L2Z31_RS12240	COG0076	glutamate decarboxylase activity
L2Z31_RS12245	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z31_RS12255	COG1309	transcriptional regulator
L2Z31_RS12270	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z31_RS12305	COG0352	thiamine-phosphate diphosphorylase activity
L2Z31_RS12330	COG0612	Peptidase, M16
L2Z31_RS12340	COG1823	symporter activity
L2Z31_RS12345	COG0583	DNA-binding transcription factor activity
L2Z31_RS12350	COG0477	Major facilitator Superfamily
L2Z31_RS12375	COG1187	pseudouridine synthase activity
L2Z31_RS12390	COG1686	Belongs to the peptidase S11 family
L2Z31_RS12395	COG1252	NADH dehydrogenase
L2Z31_RS12405	COG0415	Belongs to the DNA photolyase family
L2Z31_RS12420	COG1215	transferase activity, transferring glycosyl groups
L2Z31_RS12450	COG2070	2-Nitropropane dioxygenase
L2Z31_RS12640	COG5410	chromosome segregation
L2Z31_RS12845	COG0556	nucleotide-excision repair
L2Z31_RS12865	COG0436	Aminotransferase
L2Z31_RS12895	COG4221	oxidoreductase activity
L2Z31_RS12905	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Z31_RS12910	COG1381	Involved in DNA repair and RecF pathway recombination
L2Z31_RS12920	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Z31_RS12935	COG0681	Belongs to the peptidase S26 family
L2Z31_RS12950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z31_RS12970	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Z31_RS12975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2Z31_RS12980	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2Z31_RS12990	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2Z31_RS12995	COG4208	sulfate ABC transporter
L2Z31_RS13000	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2Z31_RS13005	COG0583	DNA-binding transcription factor activity
L2Z31_RS13010	COG4625	pathogenesis
L2Z31_RS13025	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2Z31_RS13040	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Z31_RS13050	COG1051	belongs to the nudix hydrolase family
L2Z31_RS13050	COG1056	cytidyltransferase-related domain
L2Z31_RS13055	COG1024	Enoyl-CoA hydratase
L2Z31_RS13065	COG2814	Major facilitator Superfamily
L2Z31_RS13070	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2Z31_RS13070	COG0047	phosphoribosylformylglycinamidine synthase activity
L2Z31_RS13090	COG1473	amidohydrolase
L2Z31_RS13095	COG0824	Thioesterase
L2Z31_RS13115	COG0823	Involved in the tonB-independent uptake of proteins
L2Z31_RS13135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z31_RS13170	COG0628	permease
L2Z31_RS13180	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Z31_RS13185	COG0596	Alpha beta hydrolase
L2Z31_RS13190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Z31_RS13190	COG0616	signal peptide processing
L2Z31_RS13200	COG2333	competence protein COMEC
L2Z31_RS13200	COG0658	competence protein
L2Z31_RS13205	COG1136	(ABC) transporter
L2Z31_RS13210	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Z31_RS13245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z31_RS13265	COG0463	Glycosyl transferase, family 2
L2Z31_RS13295	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z31_RS13300	COG1280	lysine exporter protein (LysE YggA)
L2Z31_RS13310	COG0019	diaminopimelate decarboxylase activity
L2Z31_RS13320	COG1113	amino acid transport
L2Z31_RS13335	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Z31_RS13345	COG3339	Conserved Protein
L2Z31_RS13350	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2Z31_RS13355	COG0243	molybdopterin cofactor binding
L2Z31_RS13360	COG1929	Belongs to the glycerate kinase type-1 family
L2Z31_RS13375	COG0778	Nitroreductase
L2Z31_RS13405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z31_RS13420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z31_RS13440	COG0741	lytic transglycosylase activity
L2Z31_RS13460	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z31_RS13465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z31_RS13490	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z31_RS13495	COG1597	lipid kinase activity
L2Z31_RS13510	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2Z31_RS13515	COG0477	Major facilitator Superfamily
L2Z31_RS13565	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Z31_RS13570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z31_RS13595	COG0505	Belongs to the CarA family
L2Z31_RS13615	COG0589	response to stress
L2Z31_RS13630	COG2843	Capsule synthesis protein
L2Z31_RS13650	COG2321	neutral zinc metallopeptidase
L2Z31_RS13655	COG2354	Protein conserved in bacteria
L2Z31_RS13675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z31_RS13700	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Z31_RS13705	COG1053	succinate dehydrogenase
L2Z31_RS13710	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Z31_RS13715	COG2009	succinate dehydrogenase
L2Z31_RS13755	COG2921	Belongs to the UPF0250 family
L2Z31_RS13760	COG0321	lipoyl(octanoyl) transferase activity
L2Z31_RS13775	COG0531	amino acid
L2Z31_RS13785	COG1733	regulation of RNA biosynthetic process
L2Z31_RS13790	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Z31_RS13795	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Z31_RS13795	COG1648	precorrin-2 dehydrogenase activity
L2Z31_RS13810	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Z31_RS13840	COG0671	phosphoesterase, PA-phosphatase related
L2Z31_RS13845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z31_RS13855	COG1538	Outer membrane efflux protein
L2Z31_RS13860	COG0393	Putative heavy-metal-binding
L2Z31_RS13865	COG0393	Putative heavy-metal-binding
L2Z31_RS13875	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z31_RS13885	COG0525	valine-tRNA ligase activity
L2Z31_RS13905	COG0583	DNA-binding transcription factor activity
L2Z31_RS13910	COG0004	ammonium transporteR
L2Z31_RS13920	COG0642	Histidine kinase
L2Z31_RS13925	COG0745	RESPONSE REGULATOR receiver
L2Z31_RS13930	COG2194	sulfuric ester hydrolase activity
L2Z31_RS13950	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z31_RS13965	COG2315	Protein conserved in bacteria
L2Z31_RS13970	COG0142	geranyltranstransferase activity
L2Z31_RS13975	COG2828	Protein conserved in bacteria
L2Z31_RS13980	COG1113	amino acid transport
L2Z31_RS14000	COG2207	Transcriptional regulator
L2Z31_RS14025	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z31_RS14035	COG0560	Phosphoserine phosphatase
L2Z31_RS14045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z31_RS14055	COG1530	ribonuclease E activity
L2Z31_RS14060	COG0424	maF-like protein
L2Z31_RS14065	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2Z31_RS14070	COG1792	Involved in formation and maintenance of cell shape
L2Z31_RS14075	COG1077	Cell shape determining protein MreB Mrl
L2Z31_RS14080	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z31_RS14090	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z31_RS14120	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2Z31_RS14125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z31_RS14130	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z31_RS14135	COG1115	amino acid carrier protein
L2Z31_RS14155	COG2814	Major facilitator Superfamily
L2Z31_RS14160	COG1289	transmembrane transporter activity
L2Z31_RS14170	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Z31_RS14210	COG1376	ErfK ybiS ycfS ynhG family protein
L2Z31_RS14215	COG2832	Protein of unknown function (DUF454)
L2Z31_RS14225	COG5510	response to toxic substance
L2Z31_RS14245	COG0840	transmembrane signaling receptor activity
L2Z31_RS14285	COG3422	double-strand break repair
L2Z31_RS14290	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Z31_RS14295	COG3189	MarR family transcriptional regulator
L2Z31_RS14305	COG0354	folic acid binding
L2Z31_RS14310	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z31_RS14320	COG0679	Auxin Efflux Carrier
L2Z31_RS14325	COG1902	pentaerythritol trinitrate reductase activity
L2Z31_RS14345	COG2094	Belongs to the DNA glycosylase MPG family
L2Z31_RS14370	COG1217	gtp-binding protein TYPA
L2Z31_RS14375	COG2233	PERMEase
L2Z31_RS14385	COG0833	amino acid
L2Z31_RS14390	COG1690	Belongs to the RtcB family
L2Z31_RS14400	COG2885	chlorophyll binding
L2Z31_RS14400	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L2Z31_RS14410	COG0183	Belongs to the thiolase family
L2Z31_RS14430	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z31_RS14450	COG2207	Transcriptional regulator
L2Z31_RS14455	COG0183	Belongs to the thiolase family
L2Z31_RS14485	COG1272	protein, Hemolysin III
L2Z31_RS14490	COG0477	Major facilitator Superfamily
L2Z31_RS14505	COG0450	alkyl hydroperoxide reductase
L2Z31_RS14525	COG0285	dihydrofolate synthase activity
L2Z31_RS14575	COG2096	Adenosyltransferase
L2Z31_RS14595	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Z31_RS14600	COG0745	RESPONSE REGULATOR receiver
L2Z31_RS14605	COG2205	protein histidine kinase activity
L2Z31_RS14615	COG1960	acyl-CoA dehydrogenase activity
L2Z31_RS14620	COG1960	acyl-CoA dehydrogenase activity
L2Z31_RS14625	COG0583	DNA-binding transcription factor activity
L2Z31_RS14630	COG0625	glutathione transferase activity
L2Z31_RS14695	COG0438	transferase activity, transferring glycosyl groups
L2Z31_RS14700	COG0463	Glycosyl transferase, family 2
L2Z31_RS14705	COG0726	polysaccharide deacetylase
L2Z31_RS14725	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Z31_RS14730	COG2205	protein histidine kinase activity
L2Z31_RS14780	COG1862	Preprotein translocase
L2Z31_RS14790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2Z31_RS14795	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Z31_RS14805	COG3781	membrane
L2Z31_RS14810	COG0613	PHP domain protein
L2Z31_RS14820	COG2350	Protein conserved in bacteria
L2Z31_RS14850	COG1607	acyl-coa hydrolase
L2Z31_RS14910	COG2199	diguanylate cyclase activity
L2Z31_RS14920	COG1408	metallophosphoesterase
L2Z31_RS14925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z31_RS14935	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Z31_RS14955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z31_RS14960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Z31_RS14975	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Z31_RS14985	COG2969	positive regulation of protein catabolic process
L2Z31_RS15005	COG1960	acyl-CoA dehydrogenase activity
L2Z31_RS15010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z31_RS15025	COG1309	transcriptional regulator
L2Z31_RS15030	COG1960	acyl-CoA dehydrogenase activity
L2Z31_RS15075	COG1183	phosphatidylcholine synthase activity
L2Z31_RS15080	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Z31_RS15110	COG0739	heme binding
L2Z31_RS15110	COG0741	lytic transglycosylase activity
L2Z31_RS15110	COG1196	nuclear chromosome segregation
L2Z31_RS15120	COG1702	phosphate starvation-inducible protein PhoH
L2Z31_RS15155	COG1295	ribonuclease BN
L2Z31_RS15160	COG0697	spore germination
L2Z31_RS15165	COG2169	Transcriptional regulator
L2Z31_RS15170	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Z31_RS15215	COG0557	exoribonuclease II activity
L2Z31_RS15220	COG0339	signal peptide processing
L2Z31_RS15225	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2Z31_RS15255	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Z31_RS15260	COG1960	acyl-CoA dehydrogenase activity
L2Z31_RS15415	COG0626	cystathionine gamma-synthase activity
L2Z31_RS15420	COG0433	COG0433 Predicted ATPase
L2Z31_RS15425	COG1017	nitric oxide dioxygenase activity
L2Z31_RS15425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z31_RS15430	COG1959	2 iron, 2 sulfur cluster binding
L2Z31_RS15445	COG1301	dicarboxylic acid transport
L2Z31_RS15450	COG1946	Acyl-CoA thioesterase
L2Z31_RS15470	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2Z31_RS15475	COG1040	competence protein
L2Z31_RS15480	COG0494	nUDIX hydrolase
L2Z31_RS15490	COG0598	Magnesium transport protein CorA
L2Z31_RS15500	COG2854	intermembrane phospholipid transfer
L2Z31_RS15510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Z31_RS15515	COG1127	ABC transporter
L2Z31_RS15525	COG0513	Belongs to the DEAD box helicase family
L2Z31_RS15545	COG0408	coproporphyrinogen oxidase activity
L2Z31_RS15565	COG1960	acyl-CoA dehydrogenase activity
L2Z31_RS15575	COG1983	PspC domain protein
L2Z31_RS15580	COG0517	IMP dehydrogenase activity
L2Z31_RS15625	COG0583	DNA-binding transcription factor activity
L2Z31_RS15665	COG1012	belongs to the aldehyde dehydrogenase family
L2Z31_RS15675	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z31_RS15680	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z31_RS15685	COG0833	amino acid
L2Z31_RS15715	COG1192	Involved in chromosome partitioning
L2Z31_RS15720	COG0628	permease
L2Z31_RS15730	COG1289	transmembrane transporter activity
L2Z31_RS15745	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z31_RS15750	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2Z31_RS15760	COG0277	FAD linked oxidase domain protein
L2Z31_RS15765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Z31_RS15790	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Z31_RS15795	COG5380	lipid catabolic process
L2Z31_RS15815	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Z31_RS15865	COG0194	GDP metabolic process
L2Z31_RS15880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z31_RS15900	COG3307	-O-antigen
L2Z31_RS15920	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2Z31_RS15925	COG1704	LemA family
L2Z31_RS15935	COG0493	'glutamate synthase
L2Z31_RS15940	COG0067	glutamate synthase
L2Z31_RS15940	COG0069	glutamate synthase activity
L2Z31_RS15940	COG0070	glutamate synthase
L2Z31_RS15990	COG2226	methyltransferase
L2Z31_RS16005	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Z31_RS16010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Z31_RS16055	COG0833	amino acid
L2Z31_RS16140	COG0488	(ABC) transporter
L2Z31_RS16145	COG2873	o-acetylhomoserine
L2Z31_RS16150	COG4221	oxidoreductase activity
L2Z31_RS16155	COG0659	secondary active sulfate transmembrane transporter activity
L2Z31_RS16180	COG0427	acetyl-CoA hydrolase
L2Z31_RS16210	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Z31_RS16240	COG2329	Antibiotic biosynthesis monooxygenase
L2Z31_RS16255	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Z31_RS16320	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z31_RS16325	COG1733	regulation of RNA biosynthetic process
L2Z31_RS16360	COG0667	Aldo Keto reductase
L2Z31_RS16380	COG0583	DNA-binding transcription factor activity
L2Z31_RS16385	COG2814	Major facilitator Superfamily
L2Z31_RS16415	COG1335	isochorismatase
L2Z31_RS16425	COG1012	belongs to the aldehyde dehydrogenase family
L2Z31_RS16430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z31_RS16440	COG1113	amino acid transport
L2Z31_RS16450	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z31_RS16465	COG2814	Major facilitator Superfamily
L2Z31_RS16475	COG0351	phosphomethylpyrimidine kinase
L2Z31_RS16475	COG0352	thiamine-phosphate diphosphorylase activity
L2Z31_RS16475	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z31_RS16495	COG1309	transcriptional regulator
L2Z31_RS16500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2Z31_RS16515	COG1002	Type II restriction enzyme, methylase subunits
L2Z31_RS16520	COG1061	Type III restriction enzyme res subunit
L2Z31_RS16555	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z31_RS16565	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z31_RS16570	COG3162	membrane
L2Z31_RS16575	COG0784	Response regulator, receiver
L2Z31_RS16575	COG2198	Histidine kinase
L2Z31_RS16575	COG2205	protein histidine kinase activity
L2Z31_RS16600	COG3328	transposase activity
L2Z31_RS16605	COG1522	sequence-specific DNA binding
L2Z31_RS16610	COG1335	isochorismatase
L2Z31_RS16615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z31_RS16625	COG0668	transmembrane transport
L2Z31_RS16630	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z31_RS16635	COG1519	Transferase
L2Z31_RS16640	COG1902	pentaerythritol trinitrate reductase activity
L2Z31_RS16660	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2Z31_RS16685	COG0426	domain, Protein
L2Z31_RS16685	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z31_RS16705	COG2119	membrane
L2Z31_RS16715	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z31_RS16725	COG4942	peptidase
L2Z31_RS16740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Z31_RS16750	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Z31_RS16770	COG0189	ligase activity
L2Z31_RS16790	COG0708	Exodeoxyribonuclease III
L2Z31_RS16795	COG1393	Belongs to the ArsC family
L2Z31_RS16810	COG3706	GGDEF domain
L2Z31_RS16845	COG2351	hydroxyisourate hydrolase activity
L2Z31_RS16850	COG2233	PERMEase
L2Z31_RS16860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z31_RS16870	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2Z31_RS16875	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z31_RS16885	COG3150	esterase
L2Z31_RS16900	COG0791	NLP P60 protein
L2Z31_RS16900	COG1388	LysM domain
L2Z31_RS16915	COG2918	glutathione biosynthetic process
L2Z31_RS16930	COG2733	membrane
L2Z31_RS16935	COG0436	Aminotransferase
L2Z31_RS16940	COG0534	Mate efflux family protein
L2Z31_RS17040	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2Z31_RS17045	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Z31_RS17055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2Z31_RS17060	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z31_RS17075	COG0010	Belongs to the arginase family
L2Z31_RS17105	COG2188	Transcriptional regulator
L2Z31_RS17115	COG0523	cobalamin synthesis protein
L2Z31_RS17125	COG1113	amino acid transport
L2Z31_RS17135	COG0625	glutathione transferase activity
L2Z31_RS17155	COG1683	Conserved Protein
L2Z31_RS17160	COG0534	Mate efflux family protein
L2Z31_RS17165	COG0385	Bile acid
L2Z31_RS17170	COG1335	isochorismatase
L2Z31_RS17175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z31_RS17195	COG2116	formate transmembrane transporter activity
L2Z31_RS17200	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Z31_RS17205	COG2133	pyrroloquinoline quinone binding
L2Z31_RS17210	COG2983	Belongs to the UPF0260 family
L2Z31_RS17230	COG1194	a g-specific adenine glycosylase
L2Z31_RS17245	COG2818	Glycosylase
L2Z31_RS17250	COG1064	alcohol dehydrogenase
L2Z31_RS17255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z31_RS17270	COG0583	DNA-binding transcription factor activity
L2Z31_RS17275	COG0656	L-ascorbic acid biosynthetic process
L2Z31_RS17280	COG2814	Major facilitator Superfamily
L2Z31_RS17315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z31_RS17330	COG2233	PERMEase
L2Z31_RS17370	COG0733	neurotransmitter:sodium symporter activity
L2Z31_RS17410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2Z31_RS17415	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2Z31_RS17420	COG0596	Alpha beta hydrolase
L2Z31_RS17445	COG0488	(ABC) transporter
L2Z31_RS17450	COG0586	Pfam SNARE associated Golgi protein
L2Z31_RS17460	COG0187	DNA topoisomerase II activity
L2Z31_RS17470	COG0592	DNA-directed DNA polymerase activity
L2Z31_RS17495	COG0706	membrane insertase activity
L2Z31_RS17510	COG1230	cation diffusion facilitator family transporter
L2Z31_RS17515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z31_RS17530	COG0402	S-adenosylhomocysteine deaminase activity
L2Z31_RS17540	COG0754	glutathionylspermidine amidase activity
L2Z31_RS17550	COG0861	Integral membrane protein TerC family
L2Z31_RS17555	COG0671	phosphoesterase, PA-phosphatase related
L2Z31_RS17565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Z31_RS17580	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Z31_RS17585	COG2951	lytic endotransglycosylase activity
L2Z31_RS17615	COG0583	DNA-binding transcription factor activity
L2Z31_RS17635	COG0657	acetylesterase activity
L2Z31_RS17640	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2Z31_RS17685	COG1047	Peptidyl-prolyl cis-trans
L2Z31_RS17695	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Z31_RS17700	COG0196	riboflavin kinase activity
L2Z31_RS17710	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2Z31_RS17715	COG1309	transcriptional regulator
L2Z31_RS17720	COG1116	anion transmembrane transporter activity
L2Z31_RS17725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z31_RS17730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z31_RS17735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z31_RS17740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z31_RS17760	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z31_RS17765	COG0546	phosphoglycolate phosphatase activity
L2Z31_RS17820	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2Z31_RS17825	COG0728	peptidoglycan biosynthetic process
L2Z31_RS17850	COG1596	polysaccharide export
L2Z31_RS17855	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z31_RS17910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L2Z31_RS17915	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L2Z31_RS17920	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Z31_RS17935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z31_RS17940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z31_RS17950	COG2186	Transcriptional regulator
L2Z31_RS17960	COG0277	FAD linked oxidase domain protein
L2Z31_RS17965	COG1448	Aminotransferase
L2Z31_RS17975	COG1802	Transcriptional regulator
L2Z31_RS17990	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2Z31_RS18060	COG0564	pseudouridine synthase activity
L2Z31_RS18100	COG0251	oxidation-reduction process
L2Z31_RS18105	COG1113	amino acid transport
L2Z31_RS18110	COG1113	amino acid transport
L2Z31_RS18130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z31_RS18135	COG1960	acyl-CoA dehydrogenase activity
L2Z31_RS18140	COG1024	Enoyl-CoA hydratase
L2Z31_RS18145	COG1024	Enoyl-CoA hydratase
L2Z31_RS18150	COG0477	Major facilitator Superfamily
L2Z31_RS18155	COG0019	diaminopimelate decarboxylase activity
L2Z31_RS18160	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z31_RS18170	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z31_RS18175	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L2Z31_RS18180	COG1846	Transcriptional regulator
L2Z31_RS18185	COG3916	Acyl-homoserine-lactone synthase
L2Z31_RS18195	COG2197	response regulator
L2Z31_RS18205	COG1960	acyl-CoA dehydrogenase activity
L2Z31_RS18210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z31_RS18210	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Z31_RS18210	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
L2Z31_RS18210	COG3321	synthase
L2Z31_RS18250	COG0271	Belongs to the BolA IbaG family
L2Z31_RS18260	COG1192	Involved in chromosome partitioning
L2Z31_RS18275	COG0586	Pfam SNARE associated Golgi protein
L2Z31_RS18280	COG2259	Doxx family
L2Z31_RS18285	COG4399	Belongs to the UPF0754 family
L2Z31_RS18290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z31_RS18290	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z31_RS18335	COG0281	malic enzyme
L2Z31_RS18340	COG2837	iron assimilation
L2Z31_RS18345	COG1280	lysine exporter protein (LysE YggA)
L2Z31_RS18350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Z31_RS18355	COG1121	(ABC) transporter
L2Z31_RS18420	COG0386	Belongs to the glutathione peroxidase family
L2Z31_RS18435	COG1309	transcriptional regulator
L2Z31_RS18440	COG0697	spore germination
L2Z31_RS18450	COG0758	DNA mediated transformation
L2Z31_RS18520	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2Z31_RS18530	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2Z31_RS18570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z31_RS18590	COG1253	flavin adenine dinucleotide binding
L2Z31_RS18600	COG2860	membrane
L2Z31_RS18605	COG0477	Major facilitator Superfamily
L2Z31_RS18615	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z31_RS18630	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Z31_RS18650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z31_RS18660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z31_RS18705	COG0589	response to stress
L2Z31_RS18710	COG0659	secondary active sulfate transmembrane transporter activity
L2Z31_RS18740	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z31_RS18785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate