locus-tag	class	description
L2Z34_RS00055	COG5410	chromosome segregation
L2Z34_RS00225	COG0069	glutamate synthase activity
L2Z34_RS00245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Z34_RS00255	COG1454	alcohol dehydrogenase
L2Z34_RS00260	COG0824	Thioesterase
L2Z34_RS00270	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z34_RS00285	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z34_RS00290	COG2030	dehydratase
L2Z34_RS00300	COG0183	Belongs to the thiolase family
L2Z34_RS00310	COG0583	DNA-binding transcription factor activity
L2Z34_RS00315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z34_RS00325	COG1522	sequence-specific DNA binding
L2Z34_RS00330	COG3135	benzoate transporter
L2Z34_RS00350	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Z34_RS00375	COG0589	response to stress
L2Z34_RS00380	COG0488	(ABC) transporter
L2Z34_RS00400	COG4773	Receptor
L2Z34_RS00435	COG0668	transmembrane transport
L2Z34_RS00445	COG1309	transcriptional regulator
L2Z34_RS00465	COG1605	Chorismate mutase
L2Z34_RS00495	COG0308	aminopeptidase N
L2Z34_RS00515	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
L2Z34_RS00525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z34_RS00530	COG1454	alcohol dehydrogenase
L2Z34_RS00550	COG0531	amino acid
L2Z34_RS00555	COG4303	Ethanolamine ammonia lyase large subunit
L2Z34_RS00560	COG4302	ethanolamine ammonia-lyase activity
L2Z34_RS00565	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z34_RS00565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z34_RS00570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z34_RS00580	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z34_RS00595	COG0697	spore germination
L2Z34_RS00600	COG1923	regulation of RNA biosynthetic process
L2Z34_RS00610	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Z34_RS00615	COG0802	atpase or kinase
L2Z34_RS00635	COG1187	pseudouridine synthase activity
L2Z34_RS00650	COG0583	DNA-binding transcription factor activity
L2Z34_RS00665	COG2814	Major facilitator Superfamily
L2Z34_RS00670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z34_RS00695	COG0729	surface antigen
L2Z34_RS00715	COG0174	glutamine synthetase
L2Z34_RS00720	COG0745	RESPONSE REGULATOR receiver
L2Z34_RS00725	COG2205	protein histidine kinase activity
L2Z34_RS00735	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2Z34_RS00740	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2Z34_RS00765	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z34_RS00770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z34_RS00775	COG1960	acyl-CoA dehydrogenase activity
L2Z34_RS00790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z34_RS00795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z34_RS00815	COG0583	DNA-binding transcription factor activity
L2Z34_RS00830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z34_RS00840	COG3658	cytochrome
L2Z34_RS00845	COG1215	transferase activity, transferring glycosyl groups
L2Z34_RS00850	COG0726	polysaccharide deacetylase
L2Z34_RS00850	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z34_RS00875	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Z34_RS00880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Z34_RS00890	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2Z34_RS00915	COG0305	Participates in initiation and elongation during chromosome replication
L2Z34_RS00920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Z34_RS00930	COG1305	Transglutaminase-like
L2Z34_RS00940	COG2308	Evidence 4 Homologs of previously reported genes of
L2Z34_RS00970	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Z34_RS00975	COG0138	bifunctional purine biosynthesis protein purh
L2Z34_RS00980	COG0151	Belongs to the GarS family
L2Z34_RS00985	COG1464	Belongs to the NlpA lipoprotein family
L2Z34_RS00990	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z34_RS00995	COG2011	ABC-type metal ion transport system permease component
L2Z34_RS01000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z34_RS01010	COG1301	dicarboxylic acid transport
L2Z34_RS01050	COG2433	Pfam Transposase IS66
L2Z34_RS01060	COG3173	Aminoglycoside phosphotransferase
L2Z34_RS01065	COG0488	(ABC) transporter
L2Z34_RS01095	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Z34_RS01095	COG3008	intermembrane lipid transfer
L2Z34_RS01100	COG2995	paraquat-inducible protein a
L2Z34_RS01110	COG2985	domain, Protein
L2Z34_RS01140	COG0477	Major facilitator Superfamily
L2Z34_RS01195	COG2186	Transcriptional regulator
L2Z34_RS01205	COG0786	glutamate:sodium symporter activity
L2Z34_RS01210	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Z34_RS01235	COG3111	PFAM Bacterial OB fold (BOF) protein
L2Z34_RS01335	COG1610	YqeY-like protein
L2Z34_RS01340	COG4783	chaperone-mediated protein folding
L2Z34_RS01350	COG3676	manually curated
L2Z34_RS01375	COG1286	toxin biosynthetic process
L2Z34_RS01405	COG0778	Nitroreductase
L2Z34_RS01415	COG0513	Belongs to the DEAD box helicase family
L2Z34_RS01440	COG2363	Small membrane protein
L2Z34_RS01470	COG1234	tRNA 3'-trailer cleavage
L2Z34_RS01475	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2Z34_RS01485	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Z34_RS01495	COG2819	hydrolase of the alpha beta superfamily
L2Z34_RS01500	COG1960	acyl-CoA dehydrogenase activity
L2Z34_RS01505	COG1301	dicarboxylic acid transport
L2Z34_RS01510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Z34_RS01515	COG3139	Protein of unknown function (DUF1315)
L2Z34_RS01520	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Z34_RS01525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Z34_RS01535	COG0494	nUDIX hydrolase
L2Z34_RS01545	COG0642	Histidine kinase
L2Z34_RS01560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Z34_RS01570	COG1720	tRNA m6t6A37 methyltransferase activity
L2Z34_RS01585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z34_RS01590	COG0826	peptidase U32
L2Z34_RS01595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z34_RS01605	COG4598	ABC transporter
L2Z34_RS01610	COG4160	amino acid transport
L2Z34_RS01615	COG4215	(ABC) transporter
L2Z34_RS01630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z34_RS01675	COG1131	(ABC) transporter
L2Z34_RS01680	COG0842	Transport permease protein
L2Z34_RS01695	COG0772	Belongs to the SEDS family
L2Z34_RS01700	COG2951	lytic endotransglycosylase activity
L2Z34_RS01725	COG2207	Transcriptional regulator
L2Z34_RS01740	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Z34_RS01745	COG0024	Methionine aminopeptidase
L2Z34_RS01755	COG2223	nitrite transmembrane transporter activity
L2Z34_RS01765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z34_RS01770	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z34_RS01800	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Z34_RS01805	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Z34_RS01810	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z34_RS01830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z34_RS01835	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2Z34_RS01840	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Z34_RS01875	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Z34_RS01885	COG0174	glutamine synthetase
L2Z34_RS01900	COG0582	viral genome integration into host DNA
L2Z34_RS01995	COG1598	PFAM Uncharacterised protein family UPF0150
L2Z34_RS02095	COG5410	chromosome segregation
L2Z34_RS02210	COG0305	Participates in initiation and elongation during chromosome replication
L2Z34_RS02315	COG0512	Glutamine amidotransferase of anthranilate synthase
L2Z34_RS02320	COG0308	aminopeptidase N
L2Z34_RS02350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2Z34_RS02360	COG0302	gtp cyclohydrolase
L2Z34_RS02385	COG3739	integral membrane protein
L2Z34_RS02400	COG1169	isochorismate synthase
L2Z34_RS02410	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z34_RS02415	COG1132	(ABC) transporter
L2Z34_RS02420	COG1132	(ABC) transporter
L2Z34_RS02435	COG3433	isochorismatase activity
L2Z34_RS02435	COG1535	isochorismatase
L2Z34_RS02440	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z34_RS02445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z34_RS02455	COG4774	siderophore transport
L2Z34_RS02460	COG4607	ABC-type enterochelin transport system periplasmic component
L2Z34_RS02465	COG4604	ABC transporter, ATP-binding protein
L2Z34_RS02470	COG4605	iron ion homeostasis
L2Z34_RS02475	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z34_RS02480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z34_RS02495	COG2964	Protein conserved in bacteria
L2Z34_RS02505	COG1741	Belongs to the pirin family
L2Z34_RS02525	COG1309	transcriptional regulator
L2Z34_RS02535	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z34_RS02540	COG2814	Major facilitator Superfamily
L2Z34_RS02575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z34_RS02575	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2Z34_RS02580	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z34_RS02590	COG1012	belongs to the aldehyde dehydrogenase family
L2Z34_RS02600	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z34_RS02605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z34_RS02610	COG0583	DNA-binding transcription factor activity
L2Z34_RS02615	COG1113	amino acid transport
L2Z34_RS02635	COG2508	Transcriptional regulator
L2Z34_RS02635	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L2Z34_RS02670	COG2879	small protein
L2Z34_RS02675	COG1966	Carbon starvation protein
L2Z34_RS02720	COG1067	ATP-dependent peptidase activity
L2Z34_RS02725	COG0583	DNA-binding transcription factor activity
L2Z34_RS02750	COG1686	Belongs to the peptidase S11 family
L2Z34_RS02755	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Z34_RS02785	COG3328	transposase activity
L2Z34_RS02800	COG0616	signal peptide processing
L2Z34_RS02805	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Z34_RS02815	COG0573	inorganic phosphate transmembrane transporter activity
L2Z34_RS02820	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Z34_RS02825	COG1113	amino acid transport
L2Z34_RS02830	COG3961	Belongs to the TPP enzyme family
L2Z34_RS02835	COG1522	sequence-specific DNA binding
L2Z34_RS02845	COG0076	glutamate decarboxylase activity
L2Z34_RS02850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z34_RS02860	COG1309	transcriptional regulator
L2Z34_RS02875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z34_RS02910	COG0352	thiamine-phosphate diphosphorylase activity
L2Z34_RS02935	COG0612	Peptidase, M16
L2Z34_RS02955	COG1823	symporter activity
L2Z34_RS02960	COG0583	DNA-binding transcription factor activity
L2Z34_RS02965	COG0477	Major facilitator Superfamily
L2Z34_RS02990	COG1187	pseudouridine synthase activity
L2Z34_RS03005	COG1686	Belongs to the peptidase S11 family
L2Z34_RS03010	COG1252	NADH dehydrogenase
L2Z34_RS03020	COG0415	Belongs to the DNA photolyase family
L2Z34_RS03035	COG1215	transferase activity, transferring glycosyl groups
L2Z34_RS03065	COG2070	2-Nitropropane dioxygenase
L2Z34_RS03120	COG0556	nucleotide-excision repair
L2Z34_RS03140	COG0436	Aminotransferase
L2Z34_RS03170	COG4221	oxidoreductase activity
L2Z34_RS03180	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Z34_RS03185	COG1381	Involved in DNA repair and RecF pathway recombination
L2Z34_RS03195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Z34_RS03210	COG0681	Belongs to the peptidase S26 family
L2Z34_RS03225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z34_RS03250	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Z34_RS03255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2Z34_RS03260	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2Z34_RS03270	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2Z34_RS03275	COG4208	sulfate ABC transporter
L2Z34_RS03280	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2Z34_RS03285	COG0583	DNA-binding transcription factor activity
L2Z34_RS03295	COG3676	manually curated
L2Z34_RS03315	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2Z34_RS03330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Z34_RS03340	COG1056	cytidyltransferase-related domain
L2Z34_RS03340	COG1051	belongs to the nudix hydrolase family
L2Z34_RS03345	COG1024	Enoyl-CoA hydratase
L2Z34_RS03355	COG2814	Major facilitator Superfamily
L2Z34_RS03360	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2Z34_RS03360	COG0047	phosphoribosylformylglycinamidine synthase activity
L2Z34_RS03380	COG1473	amidohydrolase
L2Z34_RS03385	COG0824	Thioesterase
L2Z34_RS03405	COG0823	Involved in the tonB-independent uptake of proteins
L2Z34_RS03425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z34_RS03460	COG0628	permease
L2Z34_RS03470	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Z34_RS03475	COG0596	Alpha beta hydrolase
L2Z34_RS03480	COG0616	signal peptide processing
L2Z34_RS03480	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Z34_RS03490	COG2333	competence protein COMEC
L2Z34_RS03490	COG0658	competence protein
L2Z34_RS03495	COG1136	(ABC) transporter
L2Z34_RS03500	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Z34_RS03535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z34_RS03555	COG0463	Glycosyl transferase, family 2
L2Z34_RS03585	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z34_RS03590	COG1280	lysine exporter protein (LysE YggA)
L2Z34_RS03600	COG0019	diaminopimelate decarboxylase activity
L2Z34_RS03610	COG1113	amino acid transport
L2Z34_RS03625	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Z34_RS03635	COG3339	Conserved Protein
L2Z34_RS03640	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2Z34_RS03645	COG0243	molybdopterin cofactor binding
L2Z34_RS03650	COG1929	Belongs to the glycerate kinase type-1 family
L2Z34_RS03665	COG0778	Nitroreductase
L2Z34_RS03680	COG3676	manually curated
L2Z34_RS03710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z34_RS03725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z34_RS03745	COG0741	lytic transglycosylase activity
L2Z34_RS03765	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z34_RS03795	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z34_RS03800	COG1597	lipid kinase activity
L2Z34_RS03815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2Z34_RS03820	COG0477	Major facilitator Superfamily
L2Z34_RS03870	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Z34_RS03875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z34_RS03900	COG0505	Belongs to the CarA family
L2Z34_RS03920	COG0589	response to stress
L2Z34_RS03935	COG2843	Capsule synthesis protein
L2Z34_RS03955	COG2321	neutral zinc metallopeptidase
L2Z34_RS03960	COG2354	Protein conserved in bacteria
L2Z34_RS03980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z34_RS04005	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Z34_RS04010	COG1053	succinate dehydrogenase
L2Z34_RS04015	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Z34_RS04020	COG2009	succinate dehydrogenase
L2Z34_RS04060	COG2921	Belongs to the UPF0250 family
L2Z34_RS04065	COG0321	lipoyl(octanoyl) transferase activity
L2Z34_RS04080	COG0531	amino acid
L2Z34_RS04090	COG1733	regulation of RNA biosynthetic process
L2Z34_RS04095	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Z34_RS04100	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Z34_RS04100	COG1648	precorrin-2 dehydrogenase activity
L2Z34_RS04115	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Z34_RS04145	COG0671	phosphoesterase, PA-phosphatase related
L2Z34_RS04150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z34_RS04160	COG1538	Outer membrane efflux protein
L2Z34_RS04165	COG0393	Putative heavy-metal-binding
L2Z34_RS04170	COG0393	Putative heavy-metal-binding
L2Z34_RS04180	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z34_RS04190	COG0525	valine-tRNA ligase activity
L2Z34_RS04210	COG0583	DNA-binding transcription factor activity
L2Z34_RS04215	COG0004	ammonium transporteR
L2Z34_RS04225	COG0642	Histidine kinase
L2Z34_RS04230	COG0745	RESPONSE REGULATOR receiver
L2Z34_RS04235	COG2194	sulfuric ester hydrolase activity
L2Z34_RS04255	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z34_RS04270	COG2315	Protein conserved in bacteria
L2Z34_RS04275	COG0142	geranyltranstransferase activity
L2Z34_RS04280	COG2828	Protein conserved in bacteria
L2Z34_RS04285	COG1113	amino acid transport
L2Z34_RS04305	COG2207	Transcriptional regulator
L2Z34_RS04330	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z34_RS04340	COG0560	Phosphoserine phosphatase
L2Z34_RS04350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z34_RS04360	COG1530	ribonuclease E activity
L2Z34_RS04365	COG0424	maF-like protein
L2Z34_RS04370	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2Z34_RS04375	COG1792	Involved in formation and maintenance of cell shape
L2Z34_RS04380	COG1077	Cell shape determining protein MreB Mrl
L2Z34_RS04385	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z34_RS04395	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z34_RS04435	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2Z34_RS04440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z34_RS04445	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z34_RS04450	COG1115	amino acid carrier protein
L2Z34_RS04470	COG2814	Major facilitator Superfamily
L2Z34_RS04475	COG1289	transmembrane transporter activity
L2Z34_RS04485	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Z34_RS04525	COG1376	ErfK ybiS ycfS ynhG family protein
L2Z34_RS04530	COG2832	Protein of unknown function (DUF454)
L2Z34_RS04540	COG5510	response to toxic substance
L2Z34_RS04560	COG0840	transmembrane signaling receptor activity
L2Z34_RS04605	COG3422	double-strand break repair
L2Z34_RS04610	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Z34_RS04615	COG3189	MarR family transcriptional regulator
L2Z34_RS04625	COG0354	folic acid binding
L2Z34_RS04630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z34_RS04640	COG0679	Auxin Efflux Carrier
L2Z34_RS04645	COG1902	pentaerythritol trinitrate reductase activity
L2Z34_RS04665	COG2094	Belongs to the DNA glycosylase MPG family
L2Z34_RS04690	COG1217	gtp-binding protein TYPA
L2Z34_RS04695	COG2233	PERMEase
L2Z34_RS04705	COG0833	amino acid
L2Z34_RS04710	COG1690	Belongs to the RtcB family
L2Z34_RS04720	COG2885	chlorophyll binding
L2Z34_RS04720	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L2Z34_RS04730	COG0183	Belongs to the thiolase family
L2Z34_RS04750	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z34_RS04770	COG2207	Transcriptional regulator
L2Z34_RS04775	COG0183	Belongs to the thiolase family
L2Z34_RS04805	COG1272	protein, Hemolysin III
L2Z34_RS04810	COG0477	Major facilitator Superfamily
L2Z34_RS04825	COG0450	alkyl hydroperoxide reductase
L2Z34_RS04845	COG0285	dihydrofolate synthase activity
L2Z34_RS04895	COG2096	Adenosyltransferase
L2Z34_RS04915	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Z34_RS04920	COG0745	RESPONSE REGULATOR receiver
L2Z34_RS04925	COG2205	protein histidine kinase activity
L2Z34_RS04935	COG1960	acyl-CoA dehydrogenase activity
L2Z34_RS04940	COG1960	acyl-CoA dehydrogenase activity
L2Z34_RS04945	COG0583	DNA-binding transcription factor activity
L2Z34_RS04950	COG0625	glutathione transferase activity
L2Z34_RS05015	COG0438	transferase activity, transferring glycosyl groups
L2Z34_RS05020	COG0463	Glycosyl transferase, family 2
L2Z34_RS05025	COG0726	polysaccharide deacetylase
L2Z34_RS05045	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Z34_RS05050	COG2205	protein histidine kinase activity
L2Z34_RS05080	COG1862	Preprotein translocase
L2Z34_RS05090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2Z34_RS05095	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Z34_RS05105	COG3781	membrane
L2Z34_RS05110	COG0613	PHP domain protein
L2Z34_RS05120	COG2350	Protein conserved in bacteria
L2Z34_RS05150	COG1607	acyl-coa hydrolase
L2Z34_RS05210	COG2199	diguanylate cyclase activity
L2Z34_RS05220	COG1408	metallophosphoesterase
L2Z34_RS05225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z34_RS05235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Z34_RS05255	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z34_RS05260	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Z34_RS05275	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Z34_RS05285	COG2969	positive regulation of protein catabolic process
L2Z34_RS05305	COG1960	acyl-CoA dehydrogenase activity
L2Z34_RS05310	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z34_RS05325	COG1309	transcriptional regulator
L2Z34_RS05330	COG1960	acyl-CoA dehydrogenase activity
L2Z34_RS05375	COG1183	phosphatidylcholine synthase activity
L2Z34_RS05380	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Z34_RS05410	COG0739	heme binding
L2Z34_RS05410	COG0741	lytic transglycosylase activity
L2Z34_RS05410	COG1196	nuclear chromosome segregation
L2Z34_RS05420	COG1702	phosphate starvation-inducible protein PhoH
L2Z34_RS05455	COG1295	ribonuclease BN
L2Z34_RS05460	COG0697	spore germination
L2Z34_RS05465	COG2169	Transcriptional regulator
L2Z34_RS05470	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Z34_RS05515	COG0557	exoribonuclease II activity
L2Z34_RS05520	COG0339	signal peptide processing
L2Z34_RS05525	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2Z34_RS05555	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Z34_RS05560	COG1960	acyl-CoA dehydrogenase activity
L2Z34_RS05715	COG0626	cystathionine gamma-synthase activity
L2Z34_RS05720	COG0433	COG0433 Predicted ATPase
L2Z34_RS05725	COG1017	nitric oxide dioxygenase activity
L2Z34_RS05725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z34_RS05730	COG1959	2 iron, 2 sulfur cluster binding
L2Z34_RS05745	COG1301	dicarboxylic acid transport
L2Z34_RS05750	COG1946	Acyl-CoA thioesterase
L2Z34_RS05770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2Z34_RS05775	COG1040	competence protein
L2Z34_RS05780	COG0494	nUDIX hydrolase
L2Z34_RS05790	COG0598	Magnesium transport protein CorA
L2Z34_RS05800	COG2854	intermembrane phospholipid transfer
L2Z34_RS05810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Z34_RS05815	COG1127	ABC transporter
L2Z34_RS05825	COG0513	Belongs to the DEAD box helicase family
L2Z34_RS05845	COG0408	coproporphyrinogen oxidase activity
L2Z34_RS05860	COG1960	acyl-CoA dehydrogenase activity
L2Z34_RS05870	COG1983	PspC domain protein
L2Z34_RS05875	COG0517	IMP dehydrogenase activity
L2Z34_RS05920	COG0583	DNA-binding transcription factor activity
L2Z34_RS05960	COG1012	belongs to the aldehyde dehydrogenase family
L2Z34_RS05970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z34_RS05975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z34_RS05980	COG0833	amino acid
L2Z34_RS06010	COG1192	Involved in chromosome partitioning
L2Z34_RS06015	COG0628	permease
L2Z34_RS06030	COG3676	manually curated
L2Z34_RS06050	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z34_RS06055	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2Z34_RS06065	COG0277	FAD linked oxidase domain protein
L2Z34_RS06070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Z34_RS06085	COG3676	manually curated
L2Z34_RS06100	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Z34_RS06105	COG5380	lipid catabolic process
L2Z34_RS06125	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Z34_RS06175	COG0194	GDP metabolic process
L2Z34_RS06190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z34_RS06210	COG3307	-O-antigen
L2Z34_RS06230	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2Z34_RS06235	COG1704	LemA family
L2Z34_RS06245	COG0493	'glutamate synthase
L2Z34_RS06250	COG0070	glutamate synthase
L2Z34_RS06250	COG0069	glutamate synthase activity
L2Z34_RS06250	COG0067	glutamate synthase
L2Z34_RS06300	COG2226	methyltransferase
L2Z34_RS06315	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Z34_RS06320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Z34_RS06365	COG0833	amino acid
L2Z34_RS06450	COG0488	(ABC) transporter
L2Z34_RS06455	COG2873	o-acetylhomoserine
L2Z34_RS06460	COG4221	oxidoreductase activity
L2Z34_RS06465	COG0659	secondary active sulfate transmembrane transporter activity
L2Z34_RS06490	COG0427	acetyl-CoA hydrolase
L2Z34_RS06520	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Z34_RS06550	COG2329	Antibiotic biosynthesis monooxygenase
L2Z34_RS06565	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Z34_RS06630	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z34_RS06635	COG1733	regulation of RNA biosynthetic process
L2Z34_RS06670	COG0667	Aldo Keto reductase
L2Z34_RS06690	COG3676	manually curated
L2Z34_RS06700	COG0583	DNA-binding transcription factor activity
L2Z34_RS06705	COG2814	Major facilitator Superfamily
L2Z34_RS06735	COG1335	isochorismatase
L2Z34_RS06745	COG1012	belongs to the aldehyde dehydrogenase family
L2Z34_RS06750	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z34_RS06760	COG1113	amino acid transport
L2Z34_RS06770	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z34_RS06785	COG2814	Major facilitator Superfamily
L2Z34_RS06795	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z34_RS06795	COG0352	thiamine-phosphate diphosphorylase activity
L2Z34_RS06795	COG0351	phosphomethylpyrimidine kinase
L2Z34_RS06815	COG1309	transcriptional regulator
L2Z34_RS06820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2Z34_RS06830	COG3676	manually curated
L2Z34_RS06850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z34_RS06860	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z34_RS06865	COG3162	membrane
L2Z34_RS06870	COG2205	protein histidine kinase activity
L2Z34_RS06870	COG2198	Histidine kinase
L2Z34_RS06870	COG0784	Response regulator, receiver
L2Z34_RS06895	COG3328	transposase activity
L2Z34_RS06900	COG1522	sequence-specific DNA binding
L2Z34_RS06905	COG1335	isochorismatase
L2Z34_RS06910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z34_RS06920	COG0668	transmembrane transport
L2Z34_RS06925	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z34_RS06930	COG1519	Transferase
L2Z34_RS06935	COG1902	pentaerythritol trinitrate reductase activity
L2Z34_RS06955	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2Z34_RS06980	COG0426	domain, Protein
L2Z34_RS06980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z34_RS06985	COG4774	siderophore transport
L2Z34_RS06990	COG2119	membrane
L2Z34_RS07000	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z34_RS07010	COG4942	peptidase
L2Z34_RS07025	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Z34_RS07035	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Z34_RS07055	COG0189	ligase activity
L2Z34_RS07075	COG0708	Exodeoxyribonuclease III
L2Z34_RS07080	COG1393	Belongs to the ArsC family
L2Z34_RS07095	COG3706	GGDEF domain
L2Z34_RS07130	COG2351	hydroxyisourate hydrolase activity
L2Z34_RS07135	COG2233	PERMEase
L2Z34_RS07145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z34_RS07155	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2Z34_RS07160	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z34_RS07170	COG3150	esterase
L2Z34_RS07185	COG1388	LysM domain
L2Z34_RS07185	COG0791	NLP P60 protein
L2Z34_RS07200	COG2918	glutathione biosynthetic process
L2Z34_RS07215	COG2733	membrane
L2Z34_RS07220	COG0436	Aminotransferase
L2Z34_RS07225	COG0534	Mate efflux family protein
L2Z34_RS07325	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2Z34_RS07330	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Z34_RS07340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2Z34_RS07410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z34_RS07420	COG0534	Mate efflux family protein
L2Z34_RS07435	COG4774	siderophore transport
L2Z34_RS07440	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z34_RS07460	COG0019	diaminopimelate decarboxylase activity
L2Z34_RS07465	COG3486	L-lysine 6-monooxygenase (NADPH) activity
L2Z34_RS07470	COG3676	manually curated
L2Z34_RS07480	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z34_RS07485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z34_RS07500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z34_RS07505	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z34_RS07515	COG1169	isochorismate synthase
L2Z34_RS07540	COG0084	hydrolase, TatD family'
L2Z34_RS07550	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z34_RS07565	COG0010	Belongs to the arginase family
L2Z34_RS07595	COG2188	Transcriptional regulator
L2Z34_RS07605	COG0523	cobalamin synthesis protein
L2Z34_RS07615	COG1113	amino acid transport
L2Z34_RS07625	COG0625	glutathione transferase activity
L2Z34_RS07645	COG1683	Conserved Protein
L2Z34_RS07650	COG0534	Mate efflux family protein
L2Z34_RS07655	COG0385	Bile acid
L2Z34_RS07660	COG1335	isochorismatase
L2Z34_RS07665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z34_RS07685	COG2116	formate transmembrane transporter activity
L2Z34_RS07690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Z34_RS07695	COG2133	pyrroloquinoline quinone binding
L2Z34_RS07700	COG2983	Belongs to the UPF0260 family
L2Z34_RS07720	COG1194	a g-specific adenine glycosylase
L2Z34_RS07735	COG2818	Glycosylase
L2Z34_RS07740	COG1064	alcohol dehydrogenase
L2Z34_RS07745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z34_RS07760	COG0583	DNA-binding transcription factor activity
L2Z34_RS07765	COG0656	L-ascorbic acid biosynthetic process
L2Z34_RS07770	COG2814	Major facilitator Superfamily
L2Z34_RS07805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z34_RS07820	COG2233	PERMEase
L2Z34_RS07860	COG0733	neurotransmitter:sodium symporter activity
L2Z34_RS07900	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2Z34_RS07905	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2Z34_RS07910	COG0596	Alpha beta hydrolase
L2Z34_RS07935	COG0488	(ABC) transporter
L2Z34_RS07940	COG0586	Pfam SNARE associated Golgi protein
L2Z34_RS07950	COG0187	DNA topoisomerase II activity
L2Z34_RS07960	COG0592	DNA-directed DNA polymerase activity
L2Z34_RS07985	COG0706	membrane insertase activity
L2Z34_RS08000	COG1230	cation diffusion facilitator family transporter
L2Z34_RS08005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z34_RS08020	COG0402	S-adenosylhomocysteine deaminase activity
L2Z34_RS08030	COG0754	glutathionylspermidine amidase activity
L2Z34_RS08040	COG0861	Integral membrane protein TerC family
L2Z34_RS08045	COG0671	phosphoesterase, PA-phosphatase related
L2Z34_RS08055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Z34_RS08070	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Z34_RS08075	COG2951	lytic endotransglycosylase activity
L2Z34_RS08105	COG0583	DNA-binding transcription factor activity
L2Z34_RS08125	COG0657	acetylesterase activity
L2Z34_RS08130	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2Z34_RS08170	COG1047	Peptidyl-prolyl cis-trans
L2Z34_RS08180	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Z34_RS08185	COG0196	riboflavin kinase activity
L2Z34_RS08195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2Z34_RS08200	COG1309	transcriptional regulator
L2Z34_RS08205	COG1116	anion transmembrane transporter activity
L2Z34_RS08210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z34_RS08215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z34_RS08220	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z34_RS08225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z34_RS08245	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z34_RS08250	COG0546	phosphoglycolate phosphatase activity
L2Z34_RS08305	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2Z34_RS08310	COG0728	peptidoglycan biosynthetic process
L2Z34_RS08335	COG1596	polysaccharide export
L2Z34_RS08340	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z34_RS08400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L2Z34_RS08405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L2Z34_RS08410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Z34_RS08425	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z34_RS08430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z34_RS08440	COG2186	Transcriptional regulator
L2Z34_RS08450	COG0277	FAD linked oxidase domain protein
L2Z34_RS08455	COG1448	Aminotransferase
L2Z34_RS08465	COG1802	Transcriptional regulator
L2Z34_RS08480	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2Z34_RS08540	COG0564	pseudouridine synthase activity
L2Z34_RS08580	COG0251	oxidation-reduction process
L2Z34_RS08585	COG1113	amino acid transport
L2Z34_RS08590	COG1113	amino acid transport
L2Z34_RS08610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z34_RS08615	COG1960	acyl-CoA dehydrogenase activity
L2Z34_RS08620	COG1024	Enoyl-CoA hydratase
L2Z34_RS08625	COG1024	Enoyl-CoA hydratase
L2Z34_RS08630	COG0477	Major facilitator Superfamily
L2Z34_RS08635	COG3916	Acyl-homoserine-lactone synthase
L2Z34_RS08645	COG2197	response regulator
L2Z34_RS08655	COG1960	acyl-CoA dehydrogenase activity
L2Z34_RS08660	COG3321	synthase
L2Z34_RS08660	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Z34_RS08660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z34_RS08660	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
L2Z34_RS08680	COG2267	carboxylic ester hydrolase activity
L2Z34_RS08700	COG0271	Belongs to the BolA IbaG family
L2Z34_RS08710	COG1192	Involved in chromosome partitioning
L2Z34_RS08725	COG0586	Pfam SNARE associated Golgi protein
L2Z34_RS08730	COG2259	Doxx family
L2Z34_RS08735	COG4399	Belongs to the UPF0754 family
L2Z34_RS08740	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z34_RS08740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z34_RS08785	COG0281	malic enzyme
L2Z34_RS08795	COG2837	iron assimilation
L2Z34_RS08800	COG1280	lysine exporter protein (LysE YggA)
L2Z34_RS08805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Z34_RS08810	COG1121	(ABC) transporter
L2Z34_RS08875	COG0386	Belongs to the glutathione peroxidase family
L2Z34_RS08890	COG1309	transcriptional regulator
L2Z34_RS08895	COG0697	spore germination
L2Z34_RS08905	COG0758	DNA mediated transformation
L2Z34_RS08975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2Z34_RS08985	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2Z34_RS09025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z34_RS09045	COG1253	flavin adenine dinucleotide binding
L2Z34_RS09055	COG2860	membrane
L2Z34_RS09060	COG0477	Major facilitator Superfamily
L2Z34_RS09070	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z34_RS09085	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Z34_RS09105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z34_RS09160	COG0589	response to stress
L2Z34_RS09165	COG0659	secondary active sulfate transmembrane transporter activity
L2Z34_RS09175	COG1002	Type II restriction enzyme, methylase subunits
L2Z34_RS09180	COG1061	Type III restriction enzyme res subunit
L2Z34_RS09255	COG0347	Belongs to the P(II) protein family
L2Z34_RS09260	COG0004	ammonium transporteR
L2Z34_RS09270	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z34_RS09270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z34_RS09310	COG0795	lipopolysaccharide-transporting ATPase activity
L2Z34_RS09315	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Z34_RS09320	COG0793	Belongs to the peptidase S41A family
L2Z34_RS09335	COG2197	response regulator
L2Z34_RS09345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2Z34_RS09355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z34_RS09360	COG4974	Belongs to the 'phage' integrase family
L2Z34_RS09385	COG0772	Belongs to the SEDS family
L2Z34_RS09390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z34_RS09395	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Z34_RS09400	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z34_RS09425	COG0697	spore germination
L2Z34_RS09430	COG1538	Outer membrane efflux protein
L2Z34_RS09450	COG3275	phosphorelay sensor kinase activity
L2Z34_RS09460	COG0181	hydroxymethylbilane synthase activity
L2Z34_RS09505	COG1716	ATPase activity
L2Z34_RS09510	COG0546	phosphoglycolate phosphatase activity
L2Z34_RS09605	COG0596	Alpha beta hydrolase
L2Z34_RS09610	COG2056	Na+-H+ antiporter family
L2Z34_RS09625	COG0326	Molecular chaperone. Has ATPase activity
L2Z34_RS09640	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2Z34_RS09705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2Z34_RS09710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z34_RS09710	COG2169	Transcriptional regulator
L2Z34_RS09740	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Z34_RS09750	COG0497	DNA recombination
L2Z34_RS09765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z34_RS09775	COG0237	dephospho-CoA kinase activity
L2Z34_RS09780	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L2Z34_RS09830	COG0195	Participates in both transcription termination and antitermination
L2Z34_RS09845	COG1320	monovalent cation:proton antiporter activity
L2Z34_RS09850	COG2212	antiporter activity
L2Z34_RS09855	COG1863	multisubunit Na H antiporter MnhE subunit
L2Z34_RS09860	COG0651	ATP synthesis coupled electron transport
L2Z34_RS09865	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Z34_RS09870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z34_RS09870	COG2111	Na H antiporter
L2Z34_RS09885	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Z34_RS09890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z34_RS09905	COG2226	methyltransferase
L2Z34_RS09925	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Z34_RS09930	COG1074	ATP-dependent DNA helicase activity
L2Z34_RS09935	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z34_RS09940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z34_RS09955	COG0598	Magnesium transport protein CorA
L2Z34_RS09960	COG0789	Transcriptional regulator
L2Z34_RS09965	COG0484	heat shock protein binding
L2Z34_RS09975	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L2Z34_RS09980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z34_RS09980	COG0475	glutathione-regulated potassium exporter activity
L2Z34_RS09985	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Z34_RS10005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z34_RS10015	COG4535	Mg2 and Co2 transporter CorC
L2Z34_RS10020	COG0425	Belongs to the sulfur carrier protein TusA family
L2Z34_RS10025	COG0644	oxidoreductase
L2Z34_RS10025	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2Z34_RS10035	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z34_RS10050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z34_RS10055	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2Z34_RS10095	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Z34_RS10110	COG0534	Mate efflux family protein
L2Z34_RS10120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z34_RS10125	COG4221	oxidoreductase activity
L2Z34_RS10130	COG0583	DNA-binding transcription factor activity
L2Z34_RS10145	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z34_RS10150	COG1530	ribonuclease E activity
L2Z34_RS10160	COG0546	phosphoglycolate phosphatase activity
L2Z34_RS10165	COG2378	regulation of single-species biofilm formation
L2Z34_RS10170	COG0625	glutathione transferase activity
L2Z34_RS10180	COG0583	DNA-binding transcription factor activity
L2Z34_RS10245	COG0473	3-isopropylmalate dehydrogenase activity
L2Z34_RS10300	COG1301	dicarboxylic acid transport
L2Z34_RS10310	COG1560	Kdo2-lipid A biosynthetic process
L2Z34_RS10315	COG1280	lysine exporter protein (LysE YggA)
L2Z34_RS10320	COG0488	(ABC) transporter
L2Z34_RS10325	COG2900	Belongs to the SlyX family
L2Z34_RS10335	COG1733	regulation of RNA biosynthetic process
L2Z34_RS10360	COG0210	DNA helicase
L2Z34_RS10365	COG0724	RNA recognition motif
L2Z34_RS10385	COG4651	solute:proton antiporter activity
L2Z34_RS10385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z34_RS10410	COG0788	formyltetrahydrofolate deformylase activity
L2Z34_RS10510	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z34_RS10510	COG2813	Specifically methylates the guanine in position
L2Z34_RS10520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z34_RS10530	COG4774	siderophore transport
L2Z34_RS10540	COG0740	serine-type endopeptidase activity
L2Z34_RS10560	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z34_RS10560	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z34_RS10565	COG0857	belongs to the CobB CobQ family
L2Z34_RS10565	COG0280	phosphate acetyltransferase
L2Z34_RS10570	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Z34_RS10585	COG0800	Aldolase
L2Z34_RS10595	COG3265	gluconokinase activity
L2Z34_RS10600	COG1012	belongs to the aldehyde dehydrogenase family
L2Z34_RS10610	COG2267	carboxylic ester hydrolase activity
L2Z34_RS10625	COG0793	Belongs to the peptidase S41A family
L2Z34_RS10660	COG1426	Protein conserved in bacteria
L2Z34_RS10705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z34_RS10715	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z34_RS10730	COG2986	histidine ammonia-lyase
L2Z34_RS10770	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z34_RS10775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L2Z34_RS10795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2Z34_RS10805	COG1162	GTPase activity
L2Z34_RS10810	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Z34_RS10825	COG1538	Outer membrane efflux protein
L2Z34_RS10830	COG0577	efflux transmembrane transporter activity
L2Z34_RS10830	COG1136	(ABC) transporter
L2Z34_RS10835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z34_RS10860	COG0028	Belongs to the TPP enzyme family
L2Z34_RS10865	COG0440	acetolactate synthase activity
L2Z34_RS10880	COG3676	manually curated
L2Z34_RS10900	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Z34_RS10915	COG0084	hydrolase, TatD family'
L2Z34_RS10930	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Z34_RS10940	COG0583	DNA-binding transcription factor activity
L2Z34_RS10950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z34_RS10955	COG2814	Major facilitator Superfamily
L2Z34_RS10965	COG0697	spore germination
L2Z34_RS10995	COG3622	Belongs to the hyi family
L2Z34_RS11000	COG2084	Dehydrogenase
L2Z34_RS11005	COG1024	Enoyl-CoA hydratase
L2Z34_RS11010	COG0784	Response regulator, receiver
L2Z34_RS11010	COG2205	protein histidine kinase activity
L2Z34_RS11010	COG5002	protein histidine kinase activity
L2Z34_RS11030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z34_RS11040	COG3956	TIGRFAM MazG family protein
L2Z34_RS11045	COG1555	photosystem II stabilization
L2Z34_RS11050	COG0617	tRNA 3'-terminal CCA addition
L2Z34_RS11055	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Z34_RS11075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z34_RS11080	COG3028	Belongs to the UPF0307 family
L2Z34_RS11085	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z34_RS11100	COG0625	glutathione transferase activity
L2Z34_RS11105	COG1238	metal cluster binding
L2Z34_RS11150	COG0072	phenylalanine-tRNA ligase activity
L2Z34_RS11180	COG0248	Ppx GppA phosphatase
L2Z34_RS11190	COG0037	tRNA processing
L2Z34_RS11240	COG1764	response to oxidative stress
L2Z34_RS11245	COG1846	Transcriptional regulator
L2Z34_RS11255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z34_RS11315	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2Z34_RS11320	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Z34_RS11325	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Z34_RS11335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L2Z34_RS11385	COG1214	PFAM Peptidase M22, glycoprotease
L2Z34_RS11410	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z34_RS11415	COG0561	phosphatase activity
L2Z34_RS11425	COG2132	Multicopper oxidase
L2Z34_RS11430	COG3667	copper resistance
L2Z34_RS11445	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z34_RS11450	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Z34_RS11455	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Z34_RS11485	COG1063	alcohol dehydrogenase
L2Z34_RS11490	COG0583	DNA-binding transcription factor activity
L2Z34_RS11495	COG1960	acyl-CoA dehydrogenase activity
L2Z34_RS11500	COG2814	Major facilitator Superfamily
L2Z34_RS11505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z34_RS11515	COG1053	succinate dehydrogenase
L2Z34_RS11520	COG0583	DNA-binding transcription factor activity
L2Z34_RS11535	COG0583	DNA-binding transcription factor activity
L2Z34_RS11565	COG0583	DNA-binding transcription factor activity
L2Z34_RS11580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z34_RS11605	COG0384	phenazine biosynthesis protein PhzF
L2Z34_RS11625	COG4993	Dehydrogenase
L2Z34_RS11695	COG2205	protein histidine kinase activity
L2Z34_RS11705	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Z34_RS11725	COG0745	RESPONSE REGULATOR receiver
L2Z34_RS11765	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Z34_RS11795	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z34_RS11800	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Z34_RS11820	COG0583	DNA-binding transcription factor activity
L2Z34_RS11840	COG0668	transmembrane transport
L2Z34_RS11850	COG2081	HI0933 family
L2Z34_RS11855	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z34_RS11885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z34_RS11885	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z34_RS11895	COG0489	protein tyrosine kinase activity
L2Z34_RS11945	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z34_RS11955	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Z34_RS11970	COG0730	response to heat
L2Z34_RS11980	COG1196	nuclear chromosome segregation
L2Z34_RS12000	COG2223	nitrite transmembrane transporter activity
L2Z34_RS12005	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2Z34_RS12010	COG1877	trehalose-phosphatase activity
L2Z34_RS12015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z34_RS12015	COG0596	Alpha beta hydrolase
L2Z34_RS12015	COG2226	methyltransferase
L2Z34_RS12030	COG4106	trans-aconitate 2-methyltransferase activity
L2Z34_RS12045	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Z34_RS12050	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2Z34_RS12055	COG0009	L-threonylcarbamoyladenylate synthase
L2Z34_RS12060	COG3101	peptidyl-lysine hydroxylation
L2Z34_RS12065	COG1399	metal-binding, possibly nucleic acid-binding protein
L2Z34_RS12090	COG1652	LysM domain
L2Z34_RS12095	COG0351	phosphomethylpyrimidine kinase
L2Z34_RS12095	COG0352	thiamine-phosphate diphosphorylase activity
L2Z34_RS12095	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z34_RS12105	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2Z34_RS12135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z34_RS12165	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Z34_RS12180	COG0358	DNA primase activity
L2Z34_RS12190	COG0564	pseudouridine synthase activity
L2Z34_RS12215	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z34_RS12235	COG0583	DNA-binding transcription factor activity
L2Z34_RS12240	COG0473	3-isopropylmalate dehydrogenase activity
L2Z34_RS12250	COG0657	acetylesterase activity
L2Z34_RS12260	COG1012	belongs to the aldehyde dehydrogenase family
L2Z34_RS12280	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Z34_RS12280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z34_RS12295	COG1981	membrane
L2Z34_RS12340	COG0456	acetyltransferase
L2Z34_RS12350	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Z34_RS12355	COG0492	ferredoxin-NADP+ reductase activity
L2Z34_RS12360	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Z34_RS12360	COG1674	ftsk spoiiie
L2Z34_RS12365	COG1280	lysine exporter protein (LysE YggA)
L2Z34_RS12390	COG2894	cell division
L2Z34_RS12405	COG0204	Acyl-transferase
L2Z34_RS12410	COG2885	chlorophyll binding
L2Z34_RS12415	COG0210	DNA helicase
L2Z34_RS12425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z34_RS12440	COG0121	glutamine amidotransferase
L2Z34_RS12460	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z34_RS12465	COG0735	belongs to the Fur family
L2Z34_RS12490	COG0420	3'-5' exonuclease activity
L2Z34_RS12510	COG1090	epimerase
L2Z34_RS12525	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z34_RS12535	COG2814	Major facilitator Superfamily
L2Z34_RS12540	COG0405	Gamma-glutamyltransferase
L2Z34_RS12610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z34_RS12700	COG1484	DNA-dependent DNA replication
L2Z34_RS12905	COG2026	Addiction module toxin, RelE StbE family
L2Z34_RS12945	COG0592	DNA-directed DNA polymerase activity
L2Z34_RS13070	COG0084	hydrolase, TatD family'
L2Z34_RS13090	COG0477	Major facilitator Superfamily
L2Z34_RS13095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z34_RS13110	COG1002	Type II restriction enzyme, methylase subunits
L2Z34_RS13115	COG1061	Type III restriction enzyme res subunit
L2Z34_RS13135	COG1595	DNA-templated transcription, initiation
L2Z34_RS13190	COG0531	amino acid
L2Z34_RS13195	COG2040	homocysteine
L2Z34_RS13220	COG1309	transcriptional regulator
L2Z34_RS13225	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z34_RS13230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z34_RS13240	COG1607	acyl-coa hydrolase
L2Z34_RS13250	COG0523	cobalamin synthesis protein
L2Z34_RS13260	COG4681	YaeQ
L2Z34_RS13270	COG0726	polysaccharide deacetylase
L2Z34_RS13270	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z34_RS13275	COG1215	transferase activity, transferring glycosyl groups
L2Z34_RS13285	COG1024	Enoyl-CoA hydratase
L2Z34_RS13300	COG1414	Transcriptional regulator
L2Z34_RS13320	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z34_RS13330	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z34_RS13335	COG2271	Major facilitator Superfamily
L2Z34_RS13345	COG2267	carboxylic ester hydrolase activity
L2Z34_RS13350	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z34_RS13365	COG0028	Belongs to the TPP enzyme family
L2Z34_RS13375	COG0477	Major facilitator Superfamily
L2Z34_RS13380	COG0242	peptide deformylase activity
L2Z34_RS13385	COG2066	Belongs to the glutaminase family
L2Z34_RS13390	COG2207	Transcriptional regulator
L2Z34_RS13395	COG2223	nitrite transmembrane transporter activity
L2Z34_RS13410	COG0583	DNA-binding transcription factor activity
L2Z34_RS13415	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z34_RS13420	COG2271	Major facilitator Superfamily
L2Z34_RS13425	COG3959	Transketolase, thiamine diphosphate binding domain
L2Z34_RS13430	COG3958	Transketolase
L2Z34_RS13440	COG0306	phosphate transporter
L2Z34_RS13460	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z34_RS13505	COG4181	ATPase activity
L2Z34_RS13510	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Z34_RS13535	COG0583	DNA-binding transcription factor activity
L2Z34_RS13545	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z34_RS13550	COG1773	rubredoxin
L2Z34_RS13605	COG2851	Citrate transporter
L2Z34_RS13610	COG1253	flavin adenine dinucleotide binding
L2Z34_RS13650	COG0804	urea catabolic process
L2Z34_RS13660	COG0830	nickel cation binding
L2Z34_RS13675	COG0742	ribosomal rna small subunit methyltransferase
L2Z34_RS13680	COG0768	penicillin binding
L2Z34_RS13705	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Z34_RS13710	COG2878	Part of a membrane complex involved in electron transport
L2Z34_RS13715	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z34_RS13725	COG3384	dioxygenase
L2Z34_RS13755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2Z34_RS14080	COG0739	heme binding
L2Z34_RS14170	COG0006	proline dipeptidase activity
L2Z34_RS14175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z34_RS14180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z34_RS14200	COG1279	arginine transmembrane transporter activity
L2Z34_RS14205	COG0583	DNA-binding transcription factor activity
L2Z34_RS14245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z34_RS14250	COG0741	lytic transglycosylase activity
L2Z34_RS14250	COG1388	LysM domain
L2Z34_RS14250	COG1388	LysM domain
L2Z34_RS14250	COG0741	lytic transglycosylase activity
L2Z34_RS14260	COG4174	ABC transporter (Permease)
L2Z34_RS14270	COG4172	Belongs to the ABC transporter superfamily
L2Z34_RS14295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z34_RS14305	COG2203	Gaf domain
L2Z34_RS14305	COG4251	negative regulation of phosphorylation
L2Z34_RS14305	COG5001	Diguanylate cyclase
L2Z34_RS14305	COG3706	GGDEF domain
L2Z34_RS14315	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z34_RS14315	COG1902	pentaerythritol trinitrate reductase activity
L2Z34_RS14355	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L2Z34_RS14385	COG1741	Belongs to the pirin family
L2Z34_RS14400	COG2072	flavoprotein involved in K transport
L2Z34_RS14410	COG2252	PERMEase
L2Z34_RS14415	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2Z34_RS14420	COG3038	cytochrome b561
L2Z34_RS14430	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2Z34_RS14440	COG0527	aspartate kinase activity
L2Z34_RS14450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Z34_RS14460	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Z34_RS14475	COG0667	Aldo Keto reductase
L2Z34_RS14495	COG1765	OsmC-like protein
L2Z34_RS14510	COG0542	response to heat
L2Z34_RS14545	COG2885	chlorophyll binding
L2Z34_RS14555	COG0625	glutathione transferase activity
L2Z34_RS14560	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2Z34_RS14580	COG3634	alkyl hydroperoxide reductase activity
L2Z34_RS14590	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2Z34_RS14600	COG0450	alkyl hydroperoxide reductase
L2Z34_RS14605	COG1643	Atp-dependent helicase
L2Z34_RS14620	COG2814	Major facilitator Superfamily
L2Z34_RS14625	COG3135	benzoate transporter
L2Z34_RS14630	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z34_RS14635	COG0543	2 iron, 2 sulfur cluster binding
L2Z34_RS14635	COG0633	Ferredoxin
L2Z34_RS14640	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z34_RS14645	COG4638	Rieske (2fe-2S)
L2Z34_RS14655	COG0583	DNA-binding transcription factor activity
L2Z34_RS14705	COG1570	exodeoxyribonuclease VII activity
L2Z34_RS14745	COG1278	Cold shock
L2Z34_RS14780	COG2814	Major facilitator Superfamily
L2Z34_RS14815	COG0517	IMP dehydrogenase activity
L2Z34_RS14815	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L2Z34_RS14820	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Z34_RS14830	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2Z34_RS14835	COG1137	ATPase activity
L2Z34_RS14840	COG1538	Outer membrane efflux protein
L2Z34_RS14870	COG4122	O-methyltransferase activity
L2Z34_RS14880	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2Z34_RS14895	COG1522	sequence-specific DNA binding
L2Z34_RS14900	COG5006	permease, DMT superfamily
L2Z34_RS14910	COG1560	Kdo2-lipid A biosynthetic process
L2Z34_RS14925	COG2814	Major facilitator Superfamily
L2Z34_RS14945	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z34_RS14995	COG0583	DNA-binding transcription factor activity
L2Z34_RS15000	COG1914	H( )-stimulated, divalent metal cation uptake system
L2Z34_RS15020	COG4770	biotin carboxylase activity
L2Z34_RS15025	COG0038	chloride channel
L2Z34_RS15045	COG1309	transcriptional regulator
L2Z34_RS15055	COG1063	alcohol dehydrogenase
L2Z34_RS15070	COG0439	Biotin carboxylase
L2Z34_RS15075	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z34_RS15095	COG0864	Transcriptional regulator
L2Z34_RS15105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z34_RS15110	COG1116	anion transmembrane transporter activity
L2Z34_RS15235	COG0590	tRNA wobble adenosine to inosine editing
L2Z34_RS15240	COG2807	transmembrane transport
L2Z34_RS15255	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2Z34_RS15270	COG0789	Transcriptional regulator
L2Z34_RS15280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z34_RS15300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z34_RS15310	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z34_RS15325	COG1012	belongs to the aldehyde dehydrogenase family
L2Z34_RS15330	COG0531	amino acid
L2Z34_RS15335	COG1760	l-serine dehydratase
L2Z34_RS15340	COG2030	dehydratase
L2Z34_RS15340	COG1012	belongs to the aldehyde dehydrogenase family
L2Z34_RS15345	COG3396	Phenylacetate-CoA oxygenase
L2Z34_RS15350	COG3460	Phenylacetate-CoA oxygenase
L2Z34_RS15355	COG3396	Phenylacetate-CoA oxygenase
L2Z34_RS15360	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Z34_RS15365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z34_RS15370	COG1024	Enoyl-CoA hydratase
L2Z34_RS15375	COG1024	Enoyl-CoA hydratase
L2Z34_RS15380	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z34_RS15385	COG0183	Belongs to the thiolase family
L2Z34_RS15390	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L2Z34_RS15395	COG3327	negative regulation of DNA-templated transcription, initiation
L2Z34_RS15405	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z34_RS15435	COG0753	catalase activity
L2Z34_RS15440	COG3038	cytochrome b561
L2Z34_RS15460	COG2267	carboxylic ester hydrolase activity
L2Z34_RS15465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z34_RS15470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z34_RS15475	COG1012	belongs to the aldehyde dehydrogenase family
L2Z34_RS15485	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z34_RS15495	COG1012	belongs to the aldehyde dehydrogenase family
L2Z34_RS15500	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z34_RS15505	COG0583	DNA-binding transcription factor activity
L2Z34_RS15515	COG1414	Transcriptional regulator
L2Z34_RS15520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z34_RS15530	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Z34_RS15535	COG3842	ATPase activity
L2Z34_RS15550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Z34_RS15555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z34_RS15560	COG2814	Major facilitator Superfamily
L2Z34_RS15565	COG1960	acyl-CoA dehydrogenase activity
L2Z34_RS15580	COG1024	Enoyl-CoA hydratase
L2Z34_RS15590	COG2814	Major facilitator Superfamily
L2Z34_RS15600	COG0183	Belongs to the thiolase family
L2Z34_RS15605	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z34_RS15610	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z34_RS15615	COG1024	Enoyl-CoA hydratase
L2Z34_RS15620	COG1960	acyl-CoA dehydrogenase activity
L2Z34_RS15625	COG2814	Major facilitator Superfamily
L2Z34_RS15630	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z34_RS15635	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z34_RS15645	COG2814	Major facilitator Superfamily
L2Z34_RS15655	COG1960	acyl-CoA dehydrogenase activity
L2Z34_RS15670	COG0583	DNA-binding transcription factor activity
L2Z34_RS15680	COG4770	biotin carboxylase activity
L2Z34_RS15685	COG1024	Enoyl-CoA hydratase
L2Z34_RS15690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z34_RS15695	COG1960	acyl-CoA dehydrogenase activity
L2Z34_RS15700	COG1309	transcriptional regulator
L2Z34_RS15705	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z34_RS15725	COG0583	DNA-binding transcription factor activity
L2Z34_RS15775	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z34_RS15795	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Z34_RS15815	COG2205	protein histidine kinase activity
L2Z34_RS15815	COG0784	Response regulator, receiver
L2Z34_RS15835	COG0765	amino acid transport
L2Z34_RS15840	COG0765	amino acid transport
L2Z34_RS15845	COG1126	abc transporter atp-binding protein
L2Z34_RS15850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z34_RS15855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z34_RS15870	COG1280	lysine exporter protein (LysE YggA)
L2Z34_RS15880	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2Z34_RS15885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z34_RS15890	COG1045	serine acetyltransferase
L2Z34_RS15905	COG0583	DNA-binding transcription factor activity
L2Z34_RS15910	COG0625	glutathione transferase activity
L2Z34_RS15915	COG0625	glutathione transferase activity
L2Z34_RS15920	COG0583	DNA-binding transcription factor activity
L2Z34_RS15930	COG1346	cytolysis
L2Z34_RS15950	COG2814	Major facilitator Superfamily
L2Z34_RS15960	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2Z34_RS15965	COG3052	prosthetic group binding
L2Z34_RS15985	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Z34_RS16005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z34_RS16015	COG1294	oxidase, subunit
L2Z34_RS16020	COG1271	oxidase subunit
L2Z34_RS16040	COG0477	Major facilitator Superfamily
L2Z34_RS16050	COG4521	taurine ABC transporter
L2Z34_RS16055	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2Z34_RS16060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z34_RS16065	COG2175	clavaminate synthase activity
L2Z34_RS16075	COG1953	Uracil, thiamine, allantoin
L2Z34_RS16085	COG0583	DNA-binding transcription factor activity
L2Z34_RS16095	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L2Z34_RS16110	COG0640	Transcriptional regulator
L2Z34_RS16115	COG0798	PFAM Bile acid sodium symporter
L2Z34_RS16120	COG0583	DNA-binding transcription factor activity
L2Z34_RS16135	COG3634	alkyl hydroperoxide reductase activity
L2Z34_RS16175	COG0436	Aminotransferase
L2Z34_RS16185	COG0386	Belongs to the glutathione peroxidase family
L2Z34_RS16225	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z34_RS16250	COG0012	GTP binding
L2Z34_RS16255	COG2011	ABC-type metal ion transport system permease component
L2Z34_RS16260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z34_RS16270	COG1464	Belongs to the NlpA lipoprotein family
L2Z34_RS16300	COG0765	amino acid transport
L2Z34_RS16305	COG0765	amino acid transport
L2Z34_RS16310	COG1126	abc transporter atp-binding protein
L2Z34_RS16320	COG1522	sequence-specific DNA binding
L2Z34_RS16335	COG1309	transcriptional regulator
L2Z34_RS16355	COG0583	DNA-binding transcription factor activity
L2Z34_RS16365	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z34_RS16375	COG0697	spore germination
L2Z34_RS16400	COG3121	Chaperone
L2Z34_RS16430	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Z34_RS16430	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Z34_RS16475	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Z34_RS16485	COG2353	YceI-like domain
L2Z34_RS16510	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2Z34_RS16515	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z34_RS16515	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z34_RS16515	COG0506	proline dehydrogenase activity
L2Z34_RS16525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z34_RS16530	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Z34_RS16550	COG1132	(ABC) transporter
L2Z34_RS16555	COG3122	Protein conserved in bacteria
L2Z34_RS16560	COG3619	membrane
L2Z34_RS16575	COG0640	Transcriptional regulator
L2Z34_RS16585	COG2850	peptidyl-arginine hydroxylation
L2Z34_RS16590	COG0424	maF-like protein
L2Z34_RS16610	COG0191	fructose-bisphosphate aldolase activity
L2Z34_RS16615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z34_RS16630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z34_RS16640	COG1192	Involved in chromosome partitioning
L2Z34_RS16645	COG1475	DNA binding
L2Z34_RS16650	COG0811	peptide transport
L2Z34_RS16660	COG1132	(ABC) transporter
L2Z34_RS16665	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Z34_RS16685	COG0084	hydrolase, TatD family'
L2Z34_RS16750	COG0776	regulation of translation
L2Z34_RS16780	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Z34_RS16785	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Z34_RS16835	COG0339	signal peptide processing
L2Z34_RS16845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Z34_RS16880	COG0702	epimerase
L2Z34_RS16885	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z34_RS16905	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Z34_RS16935	COG0316	Belongs to the HesB IscA family
L2Z34_RS16940	COG0822	iron-sulfur transferase activity
L2Z34_RS16965	COG0776	regulation of translation
L2Z34_RS16970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z34_RS16975	COG2207	Transcriptional regulator
L2Z34_RS16980	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z34_RS16985	COG1960	acyl-CoA dehydrogenase activity
L2Z34_RS16990	COG1960	acyl-CoA dehydrogenase activity
L2Z34_RS17005	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Z34_RS17025	COG4264	IucA IucC family
L2Z34_RS17030	COG4264	IucA IucC family
L2Z34_RS17070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z34_RS17085	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2Z34_RS17105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Z34_RS17110	COG0730	response to heat
L2Z34_RS17135	COG3676	manually curated
L2Z34_RS17145	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z34_RS17160	COG1131	(ABC) transporter
L2Z34_RS17165	COG0842	Transport permease protein
L2Z34_RS17170	COG0842	Transport permease protein
L2Z34_RS17225	COG2226	methyltransferase
L2Z34_RS17250	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Z34_RS17285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z34_RS17295	COG0133	tryptophan synthase activity
L2Z34_RS17310	COG3706	GGDEF domain
L2Z34_RS17325	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z34_RS17330	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2Z34_RS17335	COG0022	dehydrogenase e1 component
L2Z34_RS17340	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z34_RS17345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z34_RS17355	COG1063	alcohol dehydrogenase
L2Z34_RS17360	COG3781	membrane
L2Z34_RS17370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z34_RS17370	COG3453	Protein conserved in bacteria
L2Z34_RS17385	COG0730	response to heat
L2Z34_RS17400	COG2207	Transcriptional regulator
L2Z34_RS17400	COG3708	Transcriptional regulator
L2Z34_RS17405	COG1733	regulation of RNA biosynthetic process
L2Z34_RS17410	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Z34_RS17420	COG2188	Transcriptional regulator
L2Z34_RS17435	COG4521	taurine ABC transporter
L2Z34_RS17440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z34_RS17460	COG0477	Major facilitator Superfamily
L2Z34_RS17470	COG1027	Aspartate ammonia-lyase
L2Z34_RS17485	COG0583	DNA-binding transcription factor activity
L2Z34_RS17490	COG0583	DNA-binding transcription factor activity
L2Z34_RS17495	COG0183	Belongs to the thiolase family
L2Z34_RS17500	COG2031	fatty acid transporter
L2Z34_RS17505	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z34_RS17515	COG0583	DNA-binding transcription factor activity
L2Z34_RS17525	COG2610	gluconate transmembrane transporter activity
L2Z34_RS17530	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z34_RS17540	COG2207	Transcriptional regulator
L2Z34_RS17555	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z34_RS17580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z34_RS17580	COG0543	2 iron, 2 sulfur cluster binding
L2Z34_RS17585	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z34_RS17590	COG4638	Rieske (2fe-2S)
L2Z34_RS17600	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2Z34_RS17605	COG4149	molybdate abc transporter
L2Z34_RS17610	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2Z34_RS17615	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z34_RS17620	COG3433	isochorismatase activity
L2Z34_RS17620	COG1535	isochorismatase
L2Z34_RS17635	COG3539	Fimbrial protein
L2Z34_RS17655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z34_RS17675	COG2072	flavoprotein involved in K transport
L2Z34_RS17685	COG1538	Outer membrane efflux protein
L2Z34_RS17690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z34_RS17695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z34_RS17700	COG0745	RESPONSE REGULATOR receiver
L2Z34_RS17705	COG2205	protein histidine kinase activity
L2Z34_RS17715	COG2207	Transcriptional regulator
L2Z34_RS17730	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z34_RS17780	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2Z34_RS17900	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z34_RS17920	COG1120	ATPase activity
L2Z34_RS17925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z34_RS17935	COG1064	alcohol dehydrogenase
L2Z34_RS17950	COG2207	Transcriptional regulator
L2Z34_RS17955	COG2084	Dehydrogenase
L2Z34_RS17965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z34_RS17970	COG0583	DNA-binding transcription factor activity
L2Z34_RS17980	COG0129	dihydroxy-acid dehydratase activity
L2Z34_RS17985	COG1012	belongs to the aldehyde dehydrogenase family
L2Z34_RS18000	COG1566	PFAM secretion protein HlyD family protein
L2Z34_RS18020	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z34_RS18050	COG0583	DNA-binding transcription factor activity
L2Z34_RS18065	COG2188	Transcriptional regulator
L2Z34_RS18095	COG3210	domain, Protein
L2Z34_RS18100	COG2831	hemolysin activation secretion protein
L2Z34_RS18110	COG1473	amidohydrolase
L2Z34_RS18120	COG0475	glutathione-regulated potassium exporter activity
L2Z34_RS18120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z34_RS18130	COG0583	DNA-binding transcription factor activity
L2Z34_RS18135	COG1335	isochorismatase
L2Z34_RS18145	COG1309	transcriptional regulator
L2Z34_RS18175	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L2Z34_RS18185	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z34_RS18185	COG1902	pentaerythritol trinitrate reductase activity
L2Z34_RS18190	COG1846	Transcriptional regulator
L2Z34_RS18210	COG0753	catalase activity
L2Z34_RS18225	COG1012	belongs to the aldehyde dehydrogenase family
L2Z34_RS18240	COG3162	membrane
L2Z34_RS18255	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z34_RS18260	COG1960	acyl-CoA dehydrogenase activity
L2Z34_RS18280	COG1012	belongs to the aldehyde dehydrogenase family
L2Z34_RS18300	COG2186	Transcriptional regulator
L2Z34_RS18310	COG0583	DNA-binding transcription factor activity
L2Z34_RS18315	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z34_RS18320	COG4829	muconolactone delta-isomerase
L2Z34_RS18330	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z34_RS18335	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z34_RS18340	COG0183	Belongs to the thiolase family
L2Z34_RS18345	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z34_RS18355	COG1012	belongs to the aldehyde dehydrogenase family
L2Z34_RS18365	COG3733	amine oxidase
L2Z34_RS18375	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z34_RS18385	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z34_RS18395	COG4638	Rieske (2fe-2S)
L2Z34_RS18415	COG0154	amidase activity
L2Z34_RS18425	COG2814	Major facilitator Superfamily
L2Z34_RS18450	COG1960	acyl-CoA dehydrogenase activity
L2Z34_RS18455	COG0583	DNA-binding transcription factor activity
L2Z34_RS18460	COG1414	Transcriptional regulator
L2Z34_RS18475	COG2391	methyltransferase activity
L2Z34_RS18485	COG4993	Dehydrogenase
L2Z34_RS18490	COG3659	wide pore channel activity
L2Z34_RS18495	COG3420	alginic acid biosynthetic process
L2Z34_RS18500	COG0710	3-dehydroquinate dehydratase activity
L2Z34_RS18505	COG3485	protocatechuate 3,4-dioxygenase
L2Z34_RS18510	COG3485	protocatechuate 3,4-dioxygenase
L2Z34_RS18515	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z34_RS18520	COG2271	Major facilitator Superfamily
L2Z34_RS18525	COG0596	Alpha beta hydrolase
L2Z34_RS18530	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Z34_RS18535	COG0183	Belongs to the thiolase family
L2Z34_RS18540	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z34_RS18545	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z34_RS18555	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Z34_RS18560	COG2323	membrane
L2Z34_RS18605	COG1902	pentaerythritol trinitrate reductase activity
L2Z34_RS18605	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z34_RS18630	COG0542	response to heat
L2Z34_RS18635	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Z34_RS18665	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z34_RS18670	COG0569	domain protein
L2Z34_RS18675	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Z34_RS18690	COG4774	siderophore transport
L2Z34_RS18695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Z34_RS18705	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2Z34_RS18720	COG1294	oxidase, subunit
L2Z34_RS18725	COG4890	Cyd operon protein YbgT
L2Z34_RS18740	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2Z34_RS18750	COG0552	protein localization to endoplasmic reticulum
L2Z34_RS18775	COG0516	GMP reductase activity
L2Z34_RS18775	COG0517	IMP dehydrogenase activity
L2Z34_RS18780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z34_RS18785	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Z34_RS18795	COG0583	DNA-binding transcription factor activity
L2Z34_RS18800	COG0024	Methionine aminopeptidase
L2Z34_RS18830	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z34_RS18830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Z34_RS18835	COG1105	Belongs to the carbohydrate kinase PfkB family
L2Z34_RS18840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z34_RS18840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z34_RS18840	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2Z34_RS18860	COG3300	MHYT domain
L2Z34_RS18860	COG5001	Diguanylate cyclase
L2Z34_RS18875	COG2135	peptidase activity
L2Z34_RS18880	COG0659	secondary active sulfate transmembrane transporter activity
L2Z34_RS18900	COG1113	amino acid transport
L2Z34_RS18910	COG1522	sequence-specific DNA binding
L2Z34_RS18935	COG1011	Hydrolase
L2Z34_RS18940	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Z34_RS18950	COG2137	regulation of response to DNA damage stimulus
L2Z34_RS18965	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z34_RS19000	COG0575	Belongs to the CDS family
L2Z34_RS19005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Z34_RS19025	COG3852	Histidine kinase
L2Z34_RS19030	COG2204	response regulator
L2Z34_RS19085	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z34_RS19090	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Z34_RS19110	COG0697	spore germination
L2Z34_RS19115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z34_RS19125	COG0303	'Molybdopterin
L2Z34_RS19130	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Z34_RS19130	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Z34_RS19145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Z34_RS19150	COG0243	molybdopterin cofactor binding
L2Z34_RS19160	COG0243	molybdopterin cofactor binding
L2Z34_RS19165	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z34_RS19170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z34_RS19170	COG2146	nitrite reductase [NAD(P)H] activity
L2Z34_RS19180	COG0745	RESPONSE REGULATOR receiver
L2Z34_RS19185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z34_RS19185	COG1116	anion transmembrane transporter activity
L2Z34_RS19205	COG0511	ligase activity, forming carbon-carbon bonds
L2Z34_RS19220	COG2814	Major facilitator Superfamily
L2Z34_RS19285	COG0739	heme binding