locus-tag	class	description
L2Z35_RS00090	COG5410	chromosome segregation
L2Z35_RS00180	COG0305	Participates in initiation and elongation during chromosome replication
L2Z35_RS00245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z35_RS00300	COG2207	Transcriptional regulator
L2Z35_RS00325	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z35_RS00335	COG0560	Phosphoserine phosphatase
L2Z35_RS00345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z35_RS00355	COG1530	ribonuclease E activity
L2Z35_RS00360	COG0424	maF-like protein
L2Z35_RS00365	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2Z35_RS00370	COG1792	Involved in formation and maintenance of cell shape
L2Z35_RS00375	COG1077	Cell shape determining protein MreB Mrl
L2Z35_RS00380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z35_RS00390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z35_RS00425	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2Z35_RS00430	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z35_RS00435	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z35_RS00440	COG1115	amino acid carrier protein
L2Z35_RS00460	COG2814	Major facilitator Superfamily
L2Z35_RS00465	COG1289	transmembrane transporter activity
L2Z35_RS00475	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Z35_RS00515	COG1376	ErfK ybiS ycfS ynhG family protein
L2Z35_RS00520	COG2832	Protein of unknown function (DUF454)
L2Z35_RS00530	COG5510	response to toxic substance
L2Z35_RS00550	COG0840	transmembrane signaling receptor activity
L2Z35_RS00590	COG3422	double-strand break repair
L2Z35_RS00595	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Z35_RS00600	COG3189	MarR family transcriptional regulator
L2Z35_RS00610	COG0354	folic acid binding
L2Z35_RS00615	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z35_RS00625	COG0679	Auxin Efflux Carrier
L2Z35_RS00630	COG1902	pentaerythritol trinitrate reductase activity
L2Z35_RS00650	COG2094	Belongs to the DNA glycosylase MPG family
L2Z35_RS00675	COG1217	gtp-binding protein TYPA
L2Z35_RS00680	COG2233	PERMEase
L2Z35_RS00690	COG0833	amino acid
L2Z35_RS00695	COG1690	Belongs to the RtcB family
L2Z35_RS00705	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L2Z35_RS00705	COG2885	chlorophyll binding
L2Z35_RS00715	COG0183	Belongs to the thiolase family
L2Z35_RS00735	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z35_RS00755	COG2207	Transcriptional regulator
L2Z35_RS00760	COG0183	Belongs to the thiolase family
L2Z35_RS00790	COG1272	protein, Hemolysin III
L2Z35_RS00795	COG0477	Major facilitator Superfamily
L2Z35_RS00810	COG0450	alkyl hydroperoxide reductase
L2Z35_RS00830	COG0285	dihydrofolate synthase activity
L2Z35_RS00880	COG2096	Adenosyltransferase
L2Z35_RS00900	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Z35_RS00905	COG0745	RESPONSE REGULATOR receiver
L2Z35_RS00910	COG2205	protein histidine kinase activity
L2Z35_RS00920	COG1960	acyl-CoA dehydrogenase activity
L2Z35_RS00925	COG1960	acyl-CoA dehydrogenase activity
L2Z35_RS00930	COG0583	DNA-binding transcription factor activity
L2Z35_RS00935	COG0625	glutathione transferase activity
L2Z35_RS01000	COG0438	transferase activity, transferring glycosyl groups
L2Z35_RS01005	COG0463	Glycosyl transferase, family 2
L2Z35_RS01010	COG0726	polysaccharide deacetylase
L2Z35_RS01030	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Z35_RS01035	COG2205	protein histidine kinase activity
L2Z35_RS01065	COG1862	Preprotein translocase
L2Z35_RS01075	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2Z35_RS01080	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Z35_RS01090	COG3781	membrane
L2Z35_RS01095	COG0613	PHP domain protein
L2Z35_RS01105	COG2350	Protein conserved in bacteria
L2Z35_RS01135	COG1607	acyl-coa hydrolase
L2Z35_RS01195	COG2199	diguanylate cyclase activity
L2Z35_RS01205	COG1408	metallophosphoesterase
L2Z35_RS01210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z35_RS01220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Z35_RS01240	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z35_RS01245	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Z35_RS01260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Z35_RS01270	COG2969	positive regulation of protein catabolic process
L2Z35_RS01290	COG1960	acyl-CoA dehydrogenase activity
L2Z35_RS01295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z35_RS01310	COG1309	transcriptional regulator
L2Z35_RS01315	COG1960	acyl-CoA dehydrogenase activity
L2Z35_RS01320	COG3676	manually curated
L2Z35_RS01365	COG1183	phosphatidylcholine synthase activity
L2Z35_RS01370	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Z35_RS01400	COG0739	heme binding
L2Z35_RS01400	COG1196	nuclear chromosome segregation
L2Z35_RS01400	COG0741	lytic transglycosylase activity
L2Z35_RS01410	COG1702	phosphate starvation-inducible protein PhoH
L2Z35_RS01445	COG1295	ribonuclease BN
L2Z35_RS01450	COG0697	spore germination
L2Z35_RS01455	COG2169	Transcriptional regulator
L2Z35_RS01460	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Z35_RS01505	COG0557	exoribonuclease II activity
L2Z35_RS01510	COG0339	signal peptide processing
L2Z35_RS01515	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2Z35_RS01545	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Z35_RS01550	COG1960	acyl-CoA dehydrogenase activity
L2Z35_RS01705	COG0626	cystathionine gamma-synthase activity
L2Z35_RS01710	COG0433	COG0433 Predicted ATPase
L2Z35_RS01715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z35_RS01715	COG1017	nitric oxide dioxygenase activity
L2Z35_RS01720	COG1959	2 iron, 2 sulfur cluster binding
L2Z35_RS01735	COG1301	dicarboxylic acid transport
L2Z35_RS01740	COG1946	Acyl-CoA thioesterase
L2Z35_RS01760	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2Z35_RS01765	COG1040	competence protein
L2Z35_RS01770	COG0494	nUDIX hydrolase
L2Z35_RS01780	COG0598	Magnesium transport protein CorA
L2Z35_RS01790	COG2854	intermembrane phospholipid transfer
L2Z35_RS01800	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Z35_RS01805	COG1127	ABC transporter
L2Z35_RS01815	COG0513	Belongs to the DEAD box helicase family
L2Z35_RS01835	COG0408	coproporphyrinogen oxidase activity
L2Z35_RS01850	COG1960	acyl-CoA dehydrogenase activity
L2Z35_RS01860	COG1983	PspC domain protein
L2Z35_RS01865	COG0517	IMP dehydrogenase activity
L2Z35_RS01910	COG0583	DNA-binding transcription factor activity
L2Z35_RS01950	COG1012	belongs to the aldehyde dehydrogenase family
L2Z35_RS01960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z35_RS01965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z35_RS01970	COG0833	amino acid
L2Z35_RS02000	COG1192	Involved in chromosome partitioning
L2Z35_RS02005	COG0628	permease
L2Z35_RS02015	COG1289	transmembrane transporter activity
L2Z35_RS02030	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z35_RS02035	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2Z35_RS02045	COG0277	FAD linked oxidase domain protein
L2Z35_RS02050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Z35_RS02075	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Z35_RS02080	COG5380	lipid catabolic process
L2Z35_RS02100	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Z35_RS02150	COG0194	GDP metabolic process
L2Z35_RS02165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z35_RS02185	COG3307	-O-antigen
L2Z35_RS02205	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2Z35_RS02210	COG1704	LemA family
L2Z35_RS02220	COG0493	'glutamate synthase
L2Z35_RS02225	COG0069	glutamate synthase activity
L2Z35_RS02225	COG0070	glutamate synthase
L2Z35_RS02225	COG0067	glutamate synthase
L2Z35_RS02275	COG2226	methyltransferase
L2Z35_RS02290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Z35_RS02295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Z35_RS02340	COG0833	amino acid
L2Z35_RS02425	COG0488	(ABC) transporter
L2Z35_RS02430	COG2873	o-acetylhomoserine
L2Z35_RS02435	COG4221	oxidoreductase activity
L2Z35_RS02440	COG0659	secondary active sulfate transmembrane transporter activity
L2Z35_RS02465	COG0427	acetyl-CoA hydrolase
L2Z35_RS02490	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Z35_RS02520	COG2329	Antibiotic biosynthesis monooxygenase
L2Z35_RS02535	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Z35_RS02600	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z35_RS02605	COG1733	regulation of RNA biosynthetic process
L2Z35_RS02640	COG0667	Aldo Keto reductase
L2Z35_RS02660	COG0583	DNA-binding transcription factor activity
L2Z35_RS02665	COG2814	Major facilitator Superfamily
L2Z35_RS02695	COG1335	isochorismatase
L2Z35_RS02705	COG1012	belongs to the aldehyde dehydrogenase family
L2Z35_RS02710	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z35_RS02720	COG3676	manually curated
L2Z35_RS02725	COG1113	amino acid transport
L2Z35_RS02735	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z35_RS02750	COG2814	Major facilitator Superfamily
L2Z35_RS02760	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z35_RS02760	COG0352	thiamine-phosphate diphosphorylase activity
L2Z35_RS02760	COG0351	phosphomethylpyrimidine kinase
L2Z35_RS02780	COG1309	transcriptional regulator
L2Z35_RS02785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2Z35_RS02810	COG1061	Type III restriction enzyme res subunit
L2Z35_RS02815	COG1002	Type II restriction enzyme, methylase subunits
L2Z35_RS02835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z35_RS02845	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z35_RS02850	COG3162	membrane
L2Z35_RS02855	COG0784	Response regulator, receiver
L2Z35_RS02855	COG2198	Histidine kinase
L2Z35_RS02855	COG2205	protein histidine kinase activity
L2Z35_RS02880	COG3328	transposase activity
L2Z35_RS02885	COG1522	sequence-specific DNA binding
L2Z35_RS02890	COG1335	isochorismatase
L2Z35_RS02895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z35_RS02905	COG0668	transmembrane transport
L2Z35_RS02910	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z35_RS02915	COG1519	Transferase
L2Z35_RS02920	COG1902	pentaerythritol trinitrate reductase activity
L2Z35_RS02940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2Z35_RS02965	COG0426	domain, Protein
L2Z35_RS02965	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z35_RS02970	COG4774	siderophore transport
L2Z35_RS02975	COG2119	membrane
L2Z35_RS02985	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z35_RS02995	COG4942	peptidase
L2Z35_RS03010	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Z35_RS03020	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Z35_RS03040	COG0189	ligase activity
L2Z35_RS03060	COG0708	Exodeoxyribonuclease III
L2Z35_RS03065	COG1393	Belongs to the ArsC family
L2Z35_RS03080	COG3706	GGDEF domain
L2Z35_RS03115	COG2351	hydroxyisourate hydrolase activity
L2Z35_RS03120	COG2233	PERMEase
L2Z35_RS03130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z35_RS03140	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2Z35_RS03145	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z35_RS03155	COG3150	esterase
L2Z35_RS03170	COG1388	LysM domain
L2Z35_RS03170	COG0791	NLP P60 protein
L2Z35_RS03185	COG2918	glutathione biosynthetic process
L2Z35_RS03200	COG2733	membrane
L2Z35_RS03205	COG0436	Aminotransferase
L2Z35_RS03210	COG0534	Mate efflux family protein
L2Z35_RS03310	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2Z35_RS03315	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Z35_RS03325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2Z35_RS03330	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z35_RS03345	COG0010	Belongs to the arginase family
L2Z35_RS03375	COG2188	Transcriptional regulator
L2Z35_RS03385	COG0523	cobalamin synthesis protein
L2Z35_RS03395	COG1113	amino acid transport
L2Z35_RS03405	COG0625	glutathione transferase activity
L2Z35_RS03425	COG1683	Conserved Protein
L2Z35_RS03430	COG0534	Mate efflux family protein
L2Z35_RS03435	COG0385	Bile acid
L2Z35_RS03440	COG1335	isochorismatase
L2Z35_RS03445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z35_RS03465	COG2116	formate transmembrane transporter activity
L2Z35_RS03470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Z35_RS03475	COG2133	pyrroloquinoline quinone binding
L2Z35_RS03480	COG2983	Belongs to the UPF0260 family
L2Z35_RS03500	COG1194	a g-specific adenine glycosylase
L2Z35_RS03515	COG2818	Glycosylase
L2Z35_RS03520	COG1064	alcohol dehydrogenase
L2Z35_RS03525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z35_RS03540	COG0583	DNA-binding transcription factor activity
L2Z35_RS03545	COG0656	L-ascorbic acid biosynthetic process
L2Z35_RS03550	COG2814	Major facilitator Superfamily
L2Z35_RS03585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z35_RS03600	COG2233	PERMEase
L2Z35_RS03640	COG0733	neurotransmitter:sodium symporter activity
L2Z35_RS03680	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2Z35_RS03685	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2Z35_RS03715	COG0488	(ABC) transporter
L2Z35_RS03720	COG0586	Pfam SNARE associated Golgi protein
L2Z35_RS03730	COG0187	DNA topoisomerase II activity
L2Z35_RS03740	COG0592	DNA-directed DNA polymerase activity
L2Z35_RS03765	COG0706	membrane insertase activity
L2Z35_RS03780	COG1230	cation diffusion facilitator family transporter
L2Z35_RS03785	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z35_RS03800	COG0402	S-adenosylhomocysteine deaminase activity
L2Z35_RS03810	COG0754	glutathionylspermidine amidase activity
L2Z35_RS03820	COG0861	Integral membrane protein TerC family
L2Z35_RS03825	COG0671	phosphoesterase, PA-phosphatase related
L2Z35_RS03835	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Z35_RS03850	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Z35_RS03855	COG2951	lytic endotransglycosylase activity
L2Z35_RS03885	COG0583	DNA-binding transcription factor activity
L2Z35_RS03905	COG0657	acetylesterase activity
L2Z35_RS03910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2Z35_RS03950	COG1047	Peptidyl-prolyl cis-trans
L2Z35_RS03960	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Z35_RS03965	COG0196	riboflavin kinase activity
L2Z35_RS03980	COG3676	manually curated
L2Z35_RS03990	COG1309	transcriptional regulator
L2Z35_RS03995	COG1116	anion transmembrane transporter activity
L2Z35_RS04000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z35_RS04005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z35_RS04010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z35_RS04015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z35_RS04035	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z35_RS04040	COG0546	phosphoglycolate phosphatase activity
L2Z35_RS04100	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2Z35_RS04105	COG0728	peptidoglycan biosynthetic process
L2Z35_RS04130	COG1596	polysaccharide export
L2Z35_RS04135	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z35_RS04140	COG1086	Polysaccharide biosynthesis protein
L2Z35_RS04145	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L2Z35_RS04150	COG1083	cytidylyl-transferase
L2Z35_RS04165	COG2089	acid synthase
L2Z35_RS04195	COG1216	Glycosyl transferase, family 2
L2Z35_RS04200	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L2Z35_RS04205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Z35_RS04220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z35_RS04225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z35_RS04235	COG2186	Transcriptional regulator
L2Z35_RS04245	COG0277	FAD linked oxidase domain protein
L2Z35_RS04250	COG1448	Aminotransferase
L2Z35_RS04260	COG1802	Transcriptional regulator
L2Z35_RS04275	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2Z35_RS04335	COG0564	pseudouridine synthase activity
L2Z35_RS04375	COG0251	oxidation-reduction process
L2Z35_RS04380	COG1113	amino acid transport
L2Z35_RS04385	COG1113	amino acid transport
L2Z35_RS04405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z35_RS04410	COG1960	acyl-CoA dehydrogenase activity
L2Z35_RS04415	COG1024	Enoyl-CoA hydratase
L2Z35_RS04420	COG1024	Enoyl-CoA hydratase
L2Z35_RS04425	COG0477	Major facilitator Superfamily
L2Z35_RS04430	COG3916	Acyl-homoserine-lactone synthase
L2Z35_RS04440	COG2197	response regulator
L2Z35_RS04450	COG1960	acyl-CoA dehydrogenase activity
L2Z35_RS04455	COG3321	synthase
L2Z35_RS04455	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
L2Z35_RS04455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Z35_RS04455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z35_RS04475	COG2267	carboxylic ester hydrolase activity
L2Z35_RS04495	COG0271	Belongs to the BolA IbaG family
L2Z35_RS04505	COG1192	Involved in chromosome partitioning
L2Z35_RS04520	COG0586	Pfam SNARE associated Golgi protein
L2Z35_RS04525	COG2259	Doxx family
L2Z35_RS04530	COG4399	Belongs to the UPF0754 family
L2Z35_RS04535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z35_RS04535	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z35_RS04580	COG0281	malic enzyme
L2Z35_RS04590	COG2837	iron assimilation
L2Z35_RS04595	COG1280	lysine exporter protein (LysE YggA)
L2Z35_RS04600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Z35_RS04605	COG1121	(ABC) transporter
L2Z35_RS04670	COG0386	Belongs to the glutathione peroxidase family
L2Z35_RS04685	COG1309	transcriptional regulator
L2Z35_RS04690	COG0697	spore germination
L2Z35_RS04700	COG0758	DNA mediated transformation
L2Z35_RS04770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2Z35_RS04780	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2Z35_RS04820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z35_RS04840	COG1253	flavin adenine dinucleotide binding
L2Z35_RS04850	COG2860	membrane
L2Z35_RS04855	COG0477	Major facilitator Superfamily
L2Z35_RS04865	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z35_RS04880	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Z35_RS04900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z35_RS04955	COG0589	response to stress
L2Z35_RS04960	COG0659	secondary active sulfate transmembrane transporter activity
L2Z35_RS04970	COG1002	Type II restriction enzyme, methylase subunits
L2Z35_RS04975	COG1061	Type III restriction enzyme res subunit
L2Z35_RS05050	COG0347	Belongs to the P(II) protein family
L2Z35_RS05055	COG0004	ammonium transporteR
L2Z35_RS05065	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z35_RS05065	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z35_RS05105	COG0795	lipopolysaccharide-transporting ATPase activity
L2Z35_RS05110	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Z35_RS05115	COG0793	Belongs to the peptidase S41A family
L2Z35_RS05130	COG2197	response regulator
L2Z35_RS05140	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2Z35_RS05150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z35_RS05155	COG4974	Belongs to the 'phage' integrase family
L2Z35_RS05180	COG0772	Belongs to the SEDS family
L2Z35_RS05185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z35_RS05190	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Z35_RS05195	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z35_RS05220	COG0697	spore germination
L2Z35_RS05225	COG1538	Outer membrane efflux protein
L2Z35_RS05245	COG3275	phosphorelay sensor kinase activity
L2Z35_RS05255	COG0181	hydroxymethylbilane synthase activity
L2Z35_RS05300	COG1716	ATPase activity
L2Z35_RS05305	COG0546	phosphoglycolate phosphatase activity
L2Z35_RS05400	COG0596	Alpha beta hydrolase
L2Z35_RS05405	COG2056	Na+-H+ antiporter family
L2Z35_RS05420	COG0326	Molecular chaperone. Has ATPase activity
L2Z35_RS05435	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2Z35_RS05500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2Z35_RS05505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z35_RS05505	COG2169	Transcriptional regulator
L2Z35_RS05535	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Z35_RS05545	COG0497	DNA recombination
L2Z35_RS05560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z35_RS05570	COG0237	dephospho-CoA kinase activity
L2Z35_RS05575	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L2Z35_RS05625	COG0195	Participates in both transcription termination and antitermination
L2Z35_RS05640	COG1320	monovalent cation:proton antiporter activity
L2Z35_RS05645	COG2212	antiporter activity
L2Z35_RS05650	COG1863	multisubunit Na H antiporter MnhE subunit
L2Z35_RS05655	COG0651	ATP synthesis coupled electron transport
L2Z35_RS05660	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Z35_RS05665	COG2111	Na H antiporter
L2Z35_RS05665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z35_RS05680	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Z35_RS05685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z35_RS05700	COG2226	methyltransferase
L2Z35_RS05720	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Z35_RS05725	COG1074	ATP-dependent DNA helicase activity
L2Z35_RS05730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z35_RS05735	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z35_RS05750	COG0598	Magnesium transport protein CorA
L2Z35_RS05755	COG0789	Transcriptional regulator
L2Z35_RS05760	COG0484	heat shock protein binding
L2Z35_RS05770	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L2Z35_RS05775	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z35_RS05775	COG0475	glutathione-regulated potassium exporter activity
L2Z35_RS05780	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Z35_RS05800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z35_RS05810	COG4535	Mg2 and Co2 transporter CorC
L2Z35_RS05815	COG0425	Belongs to the sulfur carrier protein TusA family
L2Z35_RS05820	COG0644	oxidoreductase
L2Z35_RS05820	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2Z35_RS05830	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z35_RS05845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z35_RS05850	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2Z35_RS05890	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Z35_RS05905	COG0534	Mate efflux family protein
L2Z35_RS05915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z35_RS05920	COG4221	oxidoreductase activity
L2Z35_RS05925	COG0583	DNA-binding transcription factor activity
L2Z35_RS05940	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z35_RS05945	COG1530	ribonuclease E activity
L2Z35_RS05955	COG0546	phosphoglycolate phosphatase activity
L2Z35_RS05960	COG2378	regulation of single-species biofilm formation
L2Z35_RS05965	COG0625	glutathione transferase activity
L2Z35_RS05975	COG0583	DNA-binding transcription factor activity
L2Z35_RS06040	COG0473	3-isopropylmalate dehydrogenase activity
L2Z35_RS06095	COG1301	dicarboxylic acid transport
L2Z35_RS06105	COG1560	Kdo2-lipid A biosynthetic process
L2Z35_RS06110	COG1280	lysine exporter protein (LysE YggA)
L2Z35_RS06115	COG0488	(ABC) transporter
L2Z35_RS06120	COG2900	Belongs to the SlyX family
L2Z35_RS06130	COG1733	regulation of RNA biosynthetic process
L2Z35_RS06155	COG0210	DNA helicase
L2Z35_RS06160	COG0724	RNA recognition motif
L2Z35_RS06180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z35_RS06180	COG4651	solute:proton antiporter activity
L2Z35_RS06205	COG0788	formyltetrahydrofolate deformylase activity
L2Z35_RS06305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z35_RS06305	COG2813	Specifically methylates the guanine in position
L2Z35_RS06315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z35_RS06325	COG4774	siderophore transport
L2Z35_RS06335	COG0740	serine-type endopeptidase activity
L2Z35_RS06355	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z35_RS06355	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z35_RS06360	COG0857	belongs to the CobB CobQ family
L2Z35_RS06360	COG0280	phosphate acetyltransferase
L2Z35_RS06365	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Z35_RS06380	COG0800	Aldolase
L2Z35_RS06390	COG3265	gluconokinase activity
L2Z35_RS06395	COG1012	belongs to the aldehyde dehydrogenase family
L2Z35_RS06405	COG2267	carboxylic ester hydrolase activity
L2Z35_RS06420	COG0793	Belongs to the peptidase S41A family
L2Z35_RS06455	COG1426	Protein conserved in bacteria
L2Z35_RS06500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z35_RS06510	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z35_RS06525	COG2986	histidine ammonia-lyase
L2Z35_RS06565	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z35_RS06570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L2Z35_RS06590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2Z35_RS06600	COG1162	GTPase activity
L2Z35_RS06605	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Z35_RS06620	COG1538	Outer membrane efflux protein
L2Z35_RS06625	COG0577	efflux transmembrane transporter activity
L2Z35_RS06625	COG1136	(ABC) transporter
L2Z35_RS06630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z35_RS06655	COG0028	Belongs to the TPP enzyme family
L2Z35_RS06660	COG0440	acetolactate synthase activity
L2Z35_RS06690	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Z35_RS06705	COG0084	hydrolase, TatD family'
L2Z35_RS06720	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Z35_RS06730	COG0583	DNA-binding transcription factor activity
L2Z35_RS06740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z35_RS06745	COG2814	Major facilitator Superfamily
L2Z35_RS06755	COG0697	spore germination
L2Z35_RS06785	COG3622	Belongs to the hyi family
L2Z35_RS06790	COG2084	Dehydrogenase
L2Z35_RS06795	COG1024	Enoyl-CoA hydratase
L2Z35_RS06800	COG2205	protein histidine kinase activity
L2Z35_RS06800	COG5002	protein histidine kinase activity
L2Z35_RS06800	COG0784	Response regulator, receiver
L2Z35_RS06820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z35_RS06830	COG3956	TIGRFAM MazG family protein
L2Z35_RS06835	COG1555	photosystem II stabilization
L2Z35_RS06840	COG0617	tRNA 3'-terminal CCA addition
L2Z35_RS06845	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Z35_RS06865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z35_RS06870	COG3028	Belongs to the UPF0307 family
L2Z35_RS06875	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z35_RS06890	COG0625	glutathione transferase activity
L2Z35_RS06895	COG1238	metal cluster binding
L2Z35_RS06940	COG0072	phenylalanine-tRNA ligase activity
L2Z35_RS06970	COG0248	Ppx GppA phosphatase
L2Z35_RS06980	COG0037	tRNA processing
L2Z35_RS07030	COG1764	response to oxidative stress
L2Z35_RS07035	COG1846	Transcriptional regulator
L2Z35_RS07045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z35_RS07105	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2Z35_RS07110	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Z35_RS07115	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Z35_RS07125	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L2Z35_RS07175	COG1214	PFAM Peptidase M22, glycoprotease
L2Z35_RS07200	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z35_RS07205	COG0561	phosphatase activity
L2Z35_RS07215	COG2132	Multicopper oxidase
L2Z35_RS07220	COG3667	copper resistance
L2Z35_RS07235	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z35_RS07240	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Z35_RS07245	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Z35_RS07275	COG1063	alcohol dehydrogenase
L2Z35_RS07280	COG0583	DNA-binding transcription factor activity
L2Z35_RS07285	COG1960	acyl-CoA dehydrogenase activity
L2Z35_RS07290	COG2814	Major facilitator Superfamily
L2Z35_RS07295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z35_RS07305	COG1053	succinate dehydrogenase
L2Z35_RS07310	COG0583	DNA-binding transcription factor activity
L2Z35_RS07325	COG0583	DNA-binding transcription factor activity
L2Z35_RS07355	COG0583	DNA-binding transcription factor activity
L2Z35_RS07370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z35_RS07395	COG0384	phenazine biosynthesis protein PhzF
L2Z35_RS07420	COG4993	Dehydrogenase
L2Z35_RS07490	COG2205	protein histidine kinase activity
L2Z35_RS07500	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Z35_RS07520	COG0745	RESPONSE REGULATOR receiver
L2Z35_RS07560	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Z35_RS07590	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z35_RS07595	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Z35_RS07615	COG0583	DNA-binding transcription factor activity
L2Z35_RS07635	COG0668	transmembrane transport
L2Z35_RS07645	COG2081	HI0933 family
L2Z35_RS07650	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z35_RS07680	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z35_RS07680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z35_RS07690	COG0489	protein tyrosine kinase activity
L2Z35_RS07740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z35_RS07750	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Z35_RS07765	COG0730	response to heat
L2Z35_RS07785	COG1196	nuclear chromosome segregation
L2Z35_RS07805	COG2223	nitrite transmembrane transporter activity
L2Z35_RS07810	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2Z35_RS07815	COG1877	trehalose-phosphatase activity
L2Z35_RS07820	COG2226	methyltransferase
L2Z35_RS07820	COG0596	Alpha beta hydrolase
L2Z35_RS07820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z35_RS07835	COG4106	trans-aconitate 2-methyltransferase activity
L2Z35_RS07850	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Z35_RS07855	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2Z35_RS07860	COG0009	L-threonylcarbamoyladenylate synthase
L2Z35_RS07865	COG3101	peptidyl-lysine hydroxylation
L2Z35_RS07870	COG1399	metal-binding, possibly nucleic acid-binding protein
L2Z35_RS07895	COG1652	LysM domain
L2Z35_RS07900	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z35_RS07900	COG0351	phosphomethylpyrimidine kinase
L2Z35_RS07900	COG0352	thiamine-phosphate diphosphorylase activity
L2Z35_RS07910	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2Z35_RS07940	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z35_RS07970	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Z35_RS07985	COG0358	DNA primase activity
L2Z35_RS07995	COG0564	pseudouridine synthase activity
L2Z35_RS08020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z35_RS08040	COG0583	DNA-binding transcription factor activity
L2Z35_RS08045	COG0473	3-isopropylmalate dehydrogenase activity
L2Z35_RS08055	COG0657	acetylesterase activity
L2Z35_RS08065	COG1012	belongs to the aldehyde dehydrogenase family
L2Z35_RS08085	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Z35_RS08085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z35_RS08100	COG1981	membrane
L2Z35_RS08145	COG0456	acetyltransferase
L2Z35_RS08155	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Z35_RS08160	COG0492	ferredoxin-NADP+ reductase activity
L2Z35_RS08165	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Z35_RS08165	COG1674	ftsk spoiiie
L2Z35_RS08170	COG1280	lysine exporter protein (LysE YggA)
L2Z35_RS08190	COG2894	cell division
L2Z35_RS08205	COG0204	Acyl-transferase
L2Z35_RS08210	COG2885	chlorophyll binding
L2Z35_RS08215	COG0210	DNA helicase
L2Z35_RS08225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z35_RS08240	COG0121	glutamine amidotransferase
L2Z35_RS08260	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z35_RS08265	COG0735	belongs to the Fur family
L2Z35_RS08290	COG0420	3'-5' exonuclease activity
L2Z35_RS08310	COG1090	epimerase
L2Z35_RS08325	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z35_RS08335	COG2814	Major facilitator Superfamily
L2Z35_RS08340	COG0405	Gamma-glutamyltransferase
L2Z35_RS08410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z35_RS08500	COG1484	DNA-dependent DNA replication
L2Z35_RS08705	COG2026	Addiction module toxin, RelE StbE family
L2Z35_RS08745	COG0592	DNA-directed DNA polymerase activity
L2Z35_RS08830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z35_RS08850	COG0582	viral genome integration into host DNA
L2Z35_RS08905	COG0629	single-stranded DNA binding
L2Z35_RS08940	COG0084	hydrolase, TatD family'
L2Z35_RS08960	COG0477	Major facilitator Superfamily
L2Z35_RS08965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z35_RS08975	COG1595	DNA-templated transcription, initiation
L2Z35_RS09030	COG0531	amino acid
L2Z35_RS09035	COG2040	homocysteine
L2Z35_RS09060	COG1309	transcriptional regulator
L2Z35_RS09065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z35_RS09070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z35_RS09080	COG1607	acyl-coa hydrolase
L2Z35_RS09090	COG0523	cobalamin synthesis protein
L2Z35_RS09100	COG4681	YaeQ
L2Z35_RS09110	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z35_RS09110	COG0726	polysaccharide deacetylase
L2Z35_RS09115	COG1215	transferase activity, transferring glycosyl groups
L2Z35_RS09125	COG1024	Enoyl-CoA hydratase
L2Z35_RS09130	COG1484	DNA-dependent DNA replication
L2Z35_RS09135	COG2390	Transcriptional regulator
L2Z35_RS09135	COG4584	PFAM Integrase catalytic
L2Z35_RS09160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z35_RS09180	COG1414	Transcriptional regulator
L2Z35_RS09200	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z35_RS09210	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z35_RS09215	COG2271	Major facilitator Superfamily
L2Z35_RS09225	COG2267	carboxylic ester hydrolase activity
L2Z35_RS09230	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z35_RS09245	COG0028	Belongs to the TPP enzyme family
L2Z35_RS09255	COG0477	Major facilitator Superfamily
L2Z35_RS09260	COG0242	peptide deformylase activity
L2Z35_RS09265	COG2066	Belongs to the glutaminase family
L2Z35_RS09270	COG2207	Transcriptional regulator
L2Z35_RS09275	COG2223	nitrite transmembrane transporter activity
L2Z35_RS09290	COG0583	DNA-binding transcription factor activity
L2Z35_RS09310	COG2271	Major facilitator Superfamily
L2Z35_RS09315	COG3959	Transketolase, thiamine diphosphate binding domain
L2Z35_RS09320	COG3958	Transketolase
L2Z35_RS09330	COG0306	phosphate transporter
L2Z35_RS09350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z35_RS09395	COG4181	ATPase activity
L2Z35_RS09400	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Z35_RS09425	COG0583	DNA-binding transcription factor activity
L2Z35_RS09435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z35_RS09440	COG1773	rubredoxin
L2Z35_RS09495	COG2851	Citrate transporter
L2Z35_RS09500	COG1253	flavin adenine dinucleotide binding
L2Z35_RS09540	COG0804	urea catabolic process
L2Z35_RS09550	COG0830	nickel cation binding
L2Z35_RS09565	COG0742	ribosomal rna small subunit methyltransferase
L2Z35_RS09570	COG0768	penicillin binding
L2Z35_RS09595	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Z35_RS09600	COG2878	Part of a membrane complex involved in electron transport
L2Z35_RS09605	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z35_RS09615	COG3384	dioxygenase
L2Z35_RS09630	COG3676	manually curated
L2Z35_RS09645	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2Z35_RS09970	COG0739	heme binding
L2Z35_RS10015	COG2194	sulfuric ester hydrolase activity
L2Z35_RS10055	COG0006	proline dipeptidase activity
L2Z35_RS10060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z35_RS10065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z35_RS10085	COG1279	arginine transmembrane transporter activity
L2Z35_RS10090	COG0583	DNA-binding transcription factor activity
L2Z35_RS10130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z35_RS10135	COG0741	lytic transglycosylase activity
L2Z35_RS10135	COG1388	LysM domain
L2Z35_RS10135	COG0741	lytic transglycosylase activity
L2Z35_RS10135	COG1388	LysM domain
L2Z35_RS10145	COG4174	ABC transporter (Permease)
L2Z35_RS10150	COG4239	(ABC) transporter, permease
L2Z35_RS10155	COG4172	Belongs to the ABC transporter superfamily
L2Z35_RS10170	COG3676	manually curated
L2Z35_RS10185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z35_RS10195	COG3706	GGDEF domain
L2Z35_RS10195	COG2203	Gaf domain
L2Z35_RS10195	COG4251	negative regulation of phosphorylation
L2Z35_RS10195	COG5001	Diguanylate cyclase
L2Z35_RS10205	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z35_RS10205	COG1902	pentaerythritol trinitrate reductase activity
L2Z35_RS10245	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L2Z35_RS10270	COG1309	transcriptional regulator
L2Z35_RS10275	COG1741	Belongs to the pirin family
L2Z35_RS10290	COG2072	flavoprotein involved in K transport
L2Z35_RS10300	COG2252	PERMEase
L2Z35_RS10305	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2Z35_RS10310	COG3038	cytochrome b561
L2Z35_RS10320	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2Z35_RS10330	COG0527	aspartate kinase activity
L2Z35_RS10340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Z35_RS10350	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Z35_RS10365	COG0667	Aldo Keto reductase
L2Z35_RS10385	COG1765	OsmC-like protein
L2Z35_RS10400	COG0542	response to heat
L2Z35_RS10435	COG2885	chlorophyll binding
L2Z35_RS10445	COG0625	glutathione transferase activity
L2Z35_RS10450	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2Z35_RS10470	COG3634	alkyl hydroperoxide reductase activity
L2Z35_RS10480	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2Z35_RS10490	COG0450	alkyl hydroperoxide reductase
L2Z35_RS10495	COG1643	Atp-dependent helicase
L2Z35_RS10510	COG2814	Major facilitator Superfamily
L2Z35_RS10515	COG3135	benzoate transporter
L2Z35_RS10520	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z35_RS10525	COG0543	2 iron, 2 sulfur cluster binding
L2Z35_RS10525	COG0633	Ferredoxin
L2Z35_RS10530	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z35_RS10535	COG4638	Rieske (2fe-2S)
L2Z35_RS10545	COG0583	DNA-binding transcription factor activity
L2Z35_RS10595	COG1570	exodeoxyribonuclease VII activity
L2Z35_RS10625	COG1280	lysine exporter protein (LysE YggA)
L2Z35_RS10630	COG1278	Cold shock
L2Z35_RS10665	COG2814	Major facilitator Superfamily
L2Z35_RS10700	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L2Z35_RS10700	COG0517	IMP dehydrogenase activity
L2Z35_RS10705	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Z35_RS10715	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2Z35_RS10720	COG1137	ATPase activity
L2Z35_RS10725	COG1538	Outer membrane efflux protein
L2Z35_RS10755	COG4122	O-methyltransferase activity
L2Z35_RS10765	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2Z35_RS10780	COG1522	sequence-specific DNA binding
L2Z35_RS10785	COG5006	permease, DMT superfamily
L2Z35_RS10795	COG1560	Kdo2-lipid A biosynthetic process
L2Z35_RS10810	COG2814	Major facilitator Superfamily
L2Z35_RS10830	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z35_RS10880	COG0583	DNA-binding transcription factor activity
L2Z35_RS10885	COG1914	H( )-stimulated, divalent metal cation uptake system
L2Z35_RS10905	COG4770	biotin carboxylase activity
L2Z35_RS10910	COG0038	chloride channel
L2Z35_RS10930	COG1309	transcriptional regulator
L2Z35_RS10940	COG1063	alcohol dehydrogenase
L2Z35_RS10955	COG0439	Biotin carboxylase
L2Z35_RS10960	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z35_RS10980	COG0864	Transcriptional regulator
L2Z35_RS10990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z35_RS10995	COG1116	anion transmembrane transporter activity
L2Z35_RS11115	COG0590	tRNA wobble adenosine to inosine editing
L2Z35_RS11120	COG2807	transmembrane transport
L2Z35_RS11135	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2Z35_RS11150	COG0789	Transcriptional regulator
L2Z35_RS11160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z35_RS11180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z35_RS11190	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z35_RS11205	COG1012	belongs to the aldehyde dehydrogenase family
L2Z35_RS11210	COG0531	amino acid
L2Z35_RS11215	COG1760	l-serine dehydratase
L2Z35_RS11220	COG2030	dehydratase
L2Z35_RS11220	COG1012	belongs to the aldehyde dehydrogenase family
L2Z35_RS11225	COG3396	Phenylacetate-CoA oxygenase
L2Z35_RS11230	COG3460	Phenylacetate-CoA oxygenase
L2Z35_RS11235	COG3396	Phenylacetate-CoA oxygenase
L2Z35_RS11240	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Z35_RS11245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z35_RS11250	COG1024	Enoyl-CoA hydratase
L2Z35_RS11255	COG1024	Enoyl-CoA hydratase
L2Z35_RS11260	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z35_RS11265	COG0183	Belongs to the thiolase family
L2Z35_RS11270	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L2Z35_RS11275	COG3327	negative regulation of DNA-templated transcription, initiation
L2Z35_RS11285	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z35_RS11320	COG0753	catalase activity
L2Z35_RS11325	COG3038	cytochrome b561
L2Z35_RS11345	COG2267	carboxylic ester hydrolase activity
L2Z35_RS11350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z35_RS11355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z35_RS11360	COG1012	belongs to the aldehyde dehydrogenase family
L2Z35_RS11370	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z35_RS11380	COG1012	belongs to the aldehyde dehydrogenase family
L2Z35_RS11385	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z35_RS11390	COG0583	DNA-binding transcription factor activity
L2Z35_RS11400	COG1414	Transcriptional regulator
L2Z35_RS11405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z35_RS11415	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Z35_RS11420	COG3842	ATPase activity
L2Z35_RS11435	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Z35_RS11440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z35_RS11445	COG2814	Major facilitator Superfamily
L2Z35_RS11450	COG1960	acyl-CoA dehydrogenase activity
L2Z35_RS11465	COG1024	Enoyl-CoA hydratase
L2Z35_RS11475	COG2814	Major facilitator Superfamily
L2Z35_RS11485	COG0183	Belongs to the thiolase family
L2Z35_RS11490	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z35_RS11495	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z35_RS11500	COG1024	Enoyl-CoA hydratase
L2Z35_RS11505	COG1960	acyl-CoA dehydrogenase activity
L2Z35_RS11510	COG2814	Major facilitator Superfamily
L2Z35_RS11515	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z35_RS11520	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z35_RS11530	COG2814	Major facilitator Superfamily
L2Z35_RS11540	COG1960	acyl-CoA dehydrogenase activity
L2Z35_RS11555	COG0583	DNA-binding transcription factor activity
L2Z35_RS11565	COG4770	biotin carboxylase activity
L2Z35_RS11570	COG1024	Enoyl-CoA hydratase
L2Z35_RS11575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z35_RS11580	COG1960	acyl-CoA dehydrogenase activity
L2Z35_RS11585	COG1309	transcriptional regulator
L2Z35_RS11590	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z35_RS11610	COG0583	DNA-binding transcription factor activity
L2Z35_RS11660	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z35_RS11680	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Z35_RS11700	COG2205	protein histidine kinase activity
L2Z35_RS11700	COG0784	Response regulator, receiver
L2Z35_RS11720	COG0765	amino acid transport
L2Z35_RS11725	COG0765	amino acid transport
L2Z35_RS11730	COG1126	abc transporter atp-binding protein
L2Z35_RS11735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z35_RS11740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z35_RS11755	COG1280	lysine exporter protein (LysE YggA)
L2Z35_RS11765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2Z35_RS11770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z35_RS11775	COG1045	serine acetyltransferase
L2Z35_RS11790	COG0583	DNA-binding transcription factor activity
L2Z35_RS11795	COG0625	glutathione transferase activity
L2Z35_RS11800	COG0625	glutathione transferase activity
L2Z35_RS11805	COG0583	DNA-binding transcription factor activity
L2Z35_RS11815	COG1346	cytolysis
L2Z35_RS11835	COG2814	Major facilitator Superfamily
L2Z35_RS11845	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2Z35_RS11850	COG3052	prosthetic group binding
L2Z35_RS11870	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Z35_RS11890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z35_RS11900	COG1294	oxidase, subunit
L2Z35_RS11905	COG1271	oxidase subunit
L2Z35_RS11925	COG0477	Major facilitator Superfamily
L2Z35_RS11935	COG4521	taurine ABC transporter
L2Z35_RS11940	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2Z35_RS11945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z35_RS11950	COG2175	clavaminate synthase activity
L2Z35_RS11960	COG1953	Uracil, thiamine, allantoin
L2Z35_RS11970	COG0583	DNA-binding transcription factor activity
L2Z35_RS11980	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L2Z35_RS11995	COG0640	Transcriptional regulator
L2Z35_RS12000	COG0798	PFAM Bile acid sodium symporter
L2Z35_RS12005	COG0583	DNA-binding transcription factor activity
L2Z35_RS12020	COG3634	alkyl hydroperoxide reductase activity
L2Z35_RS12060	COG0436	Aminotransferase
L2Z35_RS12070	COG0386	Belongs to the glutathione peroxidase family
L2Z35_RS12110	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z35_RS12135	COG0012	GTP binding
L2Z35_RS12140	COG2011	ABC-type metal ion transport system permease component
L2Z35_RS12145	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z35_RS12155	COG1464	Belongs to the NlpA lipoprotein family
L2Z35_RS12185	COG0765	amino acid transport
L2Z35_RS12190	COG0765	amino acid transport
L2Z35_RS12195	COG1126	abc transporter atp-binding protein
L2Z35_RS12205	COG3676	manually curated
L2Z35_RS12210	COG1522	sequence-specific DNA binding
L2Z35_RS12225	COG1309	transcriptional regulator
L2Z35_RS12245	COG0583	DNA-binding transcription factor activity
L2Z35_RS12255	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z35_RS12265	COG0697	spore germination
L2Z35_RS12290	COG3121	Chaperone
L2Z35_RS12295	COG3539	Fimbrial protein
L2Z35_RS12320	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Z35_RS12320	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Z35_RS12365	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Z35_RS12375	COG2353	YceI-like domain
L2Z35_RS12385	COG3698	Phosphodiester glycosidase
L2Z35_RS12400	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2Z35_RS12405	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z35_RS12405	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z35_RS12405	COG0506	proline dehydrogenase activity
L2Z35_RS12415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z35_RS12420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Z35_RS12440	COG1132	(ABC) transporter
L2Z35_RS12445	COG3122	Protein conserved in bacteria
L2Z35_RS12450	COG3619	membrane
L2Z35_RS12460	COG0640	Transcriptional regulator
L2Z35_RS12470	COG2850	peptidyl-arginine hydroxylation
L2Z35_RS12475	COG0424	maF-like protein
L2Z35_RS12495	COG0191	fructose-bisphosphate aldolase activity
L2Z35_RS12500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z35_RS12515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z35_RS12525	COG1192	Involved in chromosome partitioning
L2Z35_RS12530	COG1475	DNA binding
L2Z35_RS12535	COG0811	peptide transport
L2Z35_RS12545	COG1132	(ABC) transporter
L2Z35_RS12550	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Z35_RS12570	COG0084	hydrolase, TatD family'
L2Z35_RS12635	COG0776	regulation of translation
L2Z35_RS12665	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Z35_RS12670	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Z35_RS12720	COG0339	signal peptide processing
L2Z35_RS12730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Z35_RS12765	COG0702	epimerase
L2Z35_RS12770	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z35_RS12790	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Z35_RS12820	COG0316	Belongs to the HesB IscA family
L2Z35_RS12825	COG0822	iron-sulfur transferase activity
L2Z35_RS12850	COG0776	regulation of translation
L2Z35_RS12855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z35_RS12860	COG2207	Transcriptional regulator
L2Z35_RS12865	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z35_RS12870	COG1960	acyl-CoA dehydrogenase activity
L2Z35_RS12875	COG1960	acyl-CoA dehydrogenase activity
L2Z35_RS12890	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Z35_RS12910	COG4264	IucA IucC family
L2Z35_RS12915	COG4264	IucA IucC family
L2Z35_RS12955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z35_RS12970	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2Z35_RS12990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Z35_RS12995	COG0730	response to heat
L2Z35_RS13015	COG4773	Receptor
L2Z35_RS13020	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z35_RS13035	COG1131	(ABC) transporter
L2Z35_RS13040	COG0842	Transport permease protein
L2Z35_RS13045	COG0842	Transport permease protein
L2Z35_RS13100	COG2226	methyltransferase
L2Z35_RS13125	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Z35_RS13160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z35_RS13170	COG0133	tryptophan synthase activity
L2Z35_RS13185	COG3706	GGDEF domain
L2Z35_RS13200	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z35_RS13205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2Z35_RS13210	COG0022	dehydrogenase e1 component
L2Z35_RS13215	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z35_RS13220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z35_RS13230	COG1063	alcohol dehydrogenase
L2Z35_RS13235	COG3781	membrane
L2Z35_RS13245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z35_RS13245	COG3453	Protein conserved in bacteria
L2Z35_RS13260	COG0730	response to heat
L2Z35_RS13275	COG2207	Transcriptional regulator
L2Z35_RS13275	COG3708	Transcriptional regulator
L2Z35_RS13280	COG1733	regulation of RNA biosynthetic process
L2Z35_RS13285	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Z35_RS13295	COG2188	Transcriptional regulator
L2Z35_RS13310	COG4521	taurine ABC transporter
L2Z35_RS13315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z35_RS13335	COG0477	Major facilitator Superfamily
L2Z35_RS13345	COG1027	Aspartate ammonia-lyase
L2Z35_RS13360	COG0583	DNA-binding transcription factor activity
L2Z35_RS13365	COG0583	DNA-binding transcription factor activity
L2Z35_RS13370	COG0183	Belongs to the thiolase family
L2Z35_RS13375	COG2031	fatty acid transporter
L2Z35_RS13380	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z35_RS13390	COG0583	DNA-binding transcription factor activity
L2Z35_RS13400	COG2610	gluconate transmembrane transporter activity
L2Z35_RS13405	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z35_RS13415	COG2207	Transcriptional regulator
L2Z35_RS13430	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z35_RS13455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z35_RS13455	COG0543	2 iron, 2 sulfur cluster binding
L2Z35_RS13460	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z35_RS13465	COG4638	Rieske (2fe-2S)
L2Z35_RS13475	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2Z35_RS13480	COG4149	molybdate abc transporter
L2Z35_RS13490	COG3676	manually curated
L2Z35_RS13500	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z35_RS13505	COG1535	isochorismatase
L2Z35_RS13505	COG3433	isochorismatase activity
L2Z35_RS13565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z35_RS13580	COG0753	catalase activity
L2Z35_RS13590	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L2Z35_RS13620	COG3539	Fimbrial protein
L2Z35_RS13640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z35_RS13660	COG2072	flavoprotein involved in K transport
L2Z35_RS13670	COG1538	Outer membrane efflux protein
L2Z35_RS13675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z35_RS13680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z35_RS13690	COG3676	manually curated
L2Z35_RS13700	COG2205	protein histidine kinase activity
L2Z35_RS13710	COG2207	Transcriptional regulator
L2Z35_RS13725	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z35_RS13775	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2Z35_RS13895	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z35_RS13915	COG1120	ATPase activity
L2Z35_RS13920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z35_RS13930	COG1064	alcohol dehydrogenase
L2Z35_RS13945	COG2207	Transcriptional regulator
L2Z35_RS13950	COG2084	Dehydrogenase
L2Z35_RS13960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z35_RS13965	COG0583	DNA-binding transcription factor activity
L2Z35_RS13975	COG0129	dihydroxy-acid dehydratase activity
L2Z35_RS13980	COG1012	belongs to the aldehyde dehydrogenase family
L2Z35_RS13995	COG1566	PFAM secretion protein HlyD family protein
L2Z35_RS14025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z35_RS14055	COG0583	DNA-binding transcription factor activity
L2Z35_RS14070	COG2188	Transcriptional regulator
L2Z35_RS14100	COG3210	domain, Protein
L2Z35_RS14105	COG2831	hemolysin activation secretion protein
L2Z35_RS14115	COG1473	amidohydrolase
L2Z35_RS14125	COG0475	glutathione-regulated potassium exporter activity
L2Z35_RS14125	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z35_RS14135	COG0583	DNA-binding transcription factor activity
L2Z35_RS14140	COG1335	isochorismatase
L2Z35_RS14150	COG1309	transcriptional regulator
L2Z35_RS14180	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L2Z35_RS14190	COG1902	pentaerythritol trinitrate reductase activity
L2Z35_RS14190	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z35_RS14195	COG1846	Transcriptional regulator
L2Z35_RS14215	COG0753	catalase activity
L2Z35_RS14230	COG1012	belongs to the aldehyde dehydrogenase family
L2Z35_RS14245	COG3162	membrane
L2Z35_RS14260	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z35_RS14265	COG1960	acyl-CoA dehydrogenase activity
L2Z35_RS14285	COG1012	belongs to the aldehyde dehydrogenase family
L2Z35_RS14305	COG2186	Transcriptional regulator
L2Z35_RS14315	COG0583	DNA-binding transcription factor activity
L2Z35_RS14320	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z35_RS14325	COG4829	muconolactone delta-isomerase
L2Z35_RS14335	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z35_RS14340	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z35_RS14345	COG0183	Belongs to the thiolase family
L2Z35_RS14350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z35_RS14360	COG1012	belongs to the aldehyde dehydrogenase family
L2Z35_RS14370	COG3676	manually curated
L2Z35_RS14380	COG3733	amine oxidase
L2Z35_RS14390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z35_RS14400	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z35_RS14410	COG4638	Rieske (2fe-2S)
L2Z35_RS14430	COG0154	amidase activity
L2Z35_RS14440	COG2814	Major facilitator Superfamily
L2Z35_RS14465	COG1960	acyl-CoA dehydrogenase activity
L2Z35_RS14470	COG0583	DNA-binding transcription factor activity
L2Z35_RS14475	COG1414	Transcriptional regulator
L2Z35_RS14490	COG2391	methyltransferase activity
L2Z35_RS14500	COG4993	Dehydrogenase
L2Z35_RS14505	COG3659	wide pore channel activity
L2Z35_RS14510	COG3420	alginic acid biosynthetic process
L2Z35_RS14515	COG0710	3-dehydroquinate dehydratase activity
L2Z35_RS14520	COG3485	protocatechuate 3,4-dioxygenase
L2Z35_RS14525	COG3485	protocatechuate 3,4-dioxygenase
L2Z35_RS14530	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z35_RS14535	COG2271	Major facilitator Superfamily
L2Z35_RS14540	COG0596	Alpha beta hydrolase
L2Z35_RS14545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Z35_RS14550	COG0183	Belongs to the thiolase family
L2Z35_RS14555	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z35_RS14560	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z35_RS14565	COG3676	manually curated
L2Z35_RS14575	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Z35_RS14580	COG2323	membrane
L2Z35_RS14625	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z35_RS14625	COG1902	pentaerythritol trinitrate reductase activity
L2Z35_RS14650	COG0542	response to heat
L2Z35_RS14655	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Z35_RS14685	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z35_RS14690	COG0569	domain protein
L2Z35_RS14695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Z35_RS14720	COG4774	siderophore transport
L2Z35_RS14725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Z35_RS14735	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2Z35_RS14740	COG2826	transposase and inactivated derivatives, IS30 family
L2Z35_RS14750	COG2826	transposase and inactivated derivatives, IS30 family
L2Z35_RS14765	COG1294	oxidase, subunit
L2Z35_RS14770	COG4890	Cyd operon protein YbgT
L2Z35_RS14785	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2Z35_RS14795	COG0552	protein localization to endoplasmic reticulum
L2Z35_RS14820	COG0516	GMP reductase activity
L2Z35_RS14820	COG0517	IMP dehydrogenase activity
L2Z35_RS14825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z35_RS14830	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Z35_RS14840	COG0583	DNA-binding transcription factor activity
L2Z35_RS14845	COG0024	Methionine aminopeptidase
L2Z35_RS14875	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Z35_RS14875	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z35_RS14880	COG1105	Belongs to the carbohydrate kinase PfkB family
L2Z35_RS14885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z35_RS14885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z35_RS14885	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2Z35_RS14920	COG2135	peptidase activity
L2Z35_RS14925	COG0659	secondary active sulfate transmembrane transporter activity
L2Z35_RS14945	COG1113	amino acid transport
L2Z35_RS14955	COG1522	sequence-specific DNA binding
L2Z35_RS14980	COG1011	Hydrolase
L2Z35_RS14985	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Z35_RS14995	COG2137	regulation of response to DNA damage stimulus
L2Z35_RS15010	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z35_RS15045	COG0575	Belongs to the CDS family
L2Z35_RS15050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Z35_RS15070	COG3852	Histidine kinase
L2Z35_RS15075	COG2204	response regulator
L2Z35_RS15140	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z35_RS15145	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Z35_RS15165	COG0697	spore germination
L2Z35_RS15170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z35_RS15180	COG0303	'Molybdopterin
L2Z35_RS15185	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Z35_RS15185	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Z35_RS15200	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Z35_RS15205	COG0243	molybdopterin cofactor binding
L2Z35_RS15215	COG0243	molybdopterin cofactor binding
L2Z35_RS15220	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z35_RS15225	COG2146	nitrite reductase [NAD(P)H] activity
L2Z35_RS15225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z35_RS15235	COG0745	RESPONSE REGULATOR receiver
L2Z35_RS15240	COG1116	anion transmembrane transporter activity
L2Z35_RS15240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z35_RS15255	COG0511	ligase activity, forming carbon-carbon bonds
L2Z35_RS15270	COG2814	Major facilitator Superfamily
L2Z35_RS15290	COG0069	glutamate synthase activity
L2Z35_RS15310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Z35_RS15320	COG1454	alcohol dehydrogenase
L2Z35_RS15325	COG0824	Thioesterase
L2Z35_RS15335	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z35_RS15350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z35_RS15355	COG2030	dehydratase
L2Z35_RS15365	COG0183	Belongs to the thiolase family
L2Z35_RS15375	COG0583	DNA-binding transcription factor activity
L2Z35_RS15380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z35_RS15390	COG1522	sequence-specific DNA binding
L2Z35_RS15395	COG3135	benzoate transporter
L2Z35_RS15405	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Z35_RS15430	COG0589	response to stress
L2Z35_RS15435	COG0488	(ABC) transporter
L2Z35_RS15455	COG4773	Receptor
L2Z35_RS15490	COG0668	transmembrane transport
L2Z35_RS15500	COG1309	transcriptional regulator
L2Z35_RS15520	COG1605	Chorismate mutase
L2Z35_RS15550	COG0308	aminopeptidase N
L2Z35_RS15570	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
L2Z35_RS15580	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z35_RS15585	COG1454	alcohol dehydrogenase
L2Z35_RS15605	COG0531	amino acid
L2Z35_RS15610	COG4303	Ethanolamine ammonia lyase large subunit
L2Z35_RS15615	COG4302	ethanolamine ammonia-lyase activity
L2Z35_RS15620	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z35_RS15620	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z35_RS15625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z35_RS15635	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z35_RS15650	COG0697	spore germination
L2Z35_RS15655	COG1923	regulation of RNA biosynthetic process
L2Z35_RS15665	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Z35_RS15670	COG0802	atpase or kinase
L2Z35_RS15690	COG1187	pseudouridine synthase activity
L2Z35_RS15705	COG0583	DNA-binding transcription factor activity
L2Z35_RS15720	COG2814	Major facilitator Superfamily
L2Z35_RS15725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z35_RS15750	COG0729	surface antigen
L2Z35_RS15770	COG0174	glutamine synthetase
L2Z35_RS15775	COG0745	RESPONSE REGULATOR receiver
L2Z35_RS15780	COG2205	protein histidine kinase activity
L2Z35_RS15790	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2Z35_RS15795	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2Z35_RS15820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z35_RS15825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z35_RS15830	COG1960	acyl-CoA dehydrogenase activity
L2Z35_RS15845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z35_RS15850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z35_RS15870	COG0583	DNA-binding transcription factor activity
L2Z35_RS15885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z35_RS15895	COG3658	cytochrome
L2Z35_RS15900	COG1215	transferase activity, transferring glycosyl groups
L2Z35_RS15905	COG0726	polysaccharide deacetylase
L2Z35_RS15905	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z35_RS15930	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Z35_RS15935	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Z35_RS15945	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2Z35_RS15970	COG0305	Participates in initiation and elongation during chromosome replication
L2Z35_RS15975	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Z35_RS15985	COG1305	Transglutaminase-like
L2Z35_RS15995	COG2308	Evidence 4 Homologs of previously reported genes of
L2Z35_RS16025	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Z35_RS16030	COG0138	bifunctional purine biosynthesis protein purh
L2Z35_RS16035	COG0151	Belongs to the GarS family
L2Z35_RS16040	COG1464	Belongs to the NlpA lipoprotein family
L2Z35_RS16045	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z35_RS16050	COG2011	ABC-type metal ion transport system permease component
L2Z35_RS16055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z35_RS16065	COG1301	dicarboxylic acid transport
L2Z35_RS16090	COG2433	Pfam Transposase IS66
L2Z35_RS16120	COG3173	Aminoglycoside phosphotransferase
L2Z35_RS16125	COG0488	(ABC) transporter
L2Z35_RS16155	COG3008	intermembrane lipid transfer
L2Z35_RS16155	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Z35_RS16160	COG2995	paraquat-inducible protein a
L2Z35_RS16170	COG2985	domain, Protein
L2Z35_RS16200	COG0477	Major facilitator Superfamily
L2Z35_RS16250	COG2186	Transcriptional regulator
L2Z35_RS16260	COG0786	glutamate:sodium symporter activity
L2Z35_RS16265	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Z35_RS16390	COG1610	YqeY-like protein
L2Z35_RS16395	COG4783	chaperone-mediated protein folding
L2Z35_RS16420	COG1286	toxin biosynthetic process
L2Z35_RS16450	COG0778	Nitroreductase
L2Z35_RS16460	COG0513	Belongs to the DEAD box helicase family
L2Z35_RS16485	COG2363	Small membrane protein
L2Z35_RS16515	COG1234	tRNA 3'-trailer cleavage
L2Z35_RS16520	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2Z35_RS16530	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Z35_RS16540	COG2819	hydrolase of the alpha beta superfamily
L2Z35_RS16545	COG1960	acyl-CoA dehydrogenase activity
L2Z35_RS16550	COG1301	dicarboxylic acid transport
L2Z35_RS16555	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Z35_RS16560	COG3139	Protein of unknown function (DUF1315)
L2Z35_RS16565	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Z35_RS16570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Z35_RS16580	COG0494	nUDIX hydrolase
L2Z35_RS16590	COG0642	Histidine kinase
L2Z35_RS16605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Z35_RS16615	COG1720	tRNA m6t6A37 methyltransferase activity
L2Z35_RS16630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z35_RS16635	COG0826	peptidase U32
L2Z35_RS16640	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z35_RS16650	COG4598	ABC transporter
L2Z35_RS16655	COG4160	amino acid transport
L2Z35_RS16660	COG4215	(ABC) transporter
L2Z35_RS16675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z35_RS16705	COG3676	manually curated
L2Z35_RS16730	COG1131	(ABC) transporter
L2Z35_RS16735	COG0842	Transport permease protein
L2Z35_RS16750	COG0772	Belongs to the SEDS family
L2Z35_RS16755	COG2951	lytic endotransglycosylase activity
L2Z35_RS16780	COG2207	Transcriptional regulator
L2Z35_RS16795	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Z35_RS16800	COG0024	Methionine aminopeptidase
L2Z35_RS16810	COG2223	nitrite transmembrane transporter activity
L2Z35_RS16820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z35_RS16825	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z35_RS16830	COG1960	acyl-CoA dehydrogenase activity
L2Z35_RS16845	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Z35_RS16850	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Z35_RS16855	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z35_RS16875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z35_RS16880	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2Z35_RS16885	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Z35_RS16920	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Z35_RS16930	COG0174	glutamine synthetase
L2Z35_RS16945	COG0582	viral genome integration into host DNA
L2Z35_RS16995	COG0739	heme binding
L2Z35_RS17140	COG5410	chromosome segregation
L2Z35_RS17305	COG0512	Glutamine amidotransferase of anthranilate synthase
L2Z35_RS17310	COG0308	aminopeptidase N
L2Z35_RS17340	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2Z35_RS17350	COG0302	gtp cyclohydrolase
L2Z35_RS17375	COG3739	integral membrane protein
L2Z35_RS17390	COG1169	isochorismate synthase
L2Z35_RS17400	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z35_RS17405	COG1132	(ABC) transporter
L2Z35_RS17410	COG1132	(ABC) transporter
L2Z35_RS17425	COG1535	isochorismatase
L2Z35_RS17425	COG3433	isochorismatase activity
L2Z35_RS17430	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z35_RS17435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z35_RS17445	COG4774	siderophore transport
L2Z35_RS17450	COG4607	ABC-type enterochelin transport system periplasmic component
L2Z35_RS17455	COG4604	ABC transporter, ATP-binding protein
L2Z35_RS17460	COG4605	iron ion homeostasis
L2Z35_RS17465	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z35_RS17470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z35_RS17485	COG2964	Protein conserved in bacteria
L2Z35_RS17495	COG1741	Belongs to the pirin family
L2Z35_RS17515	COG1309	transcriptional regulator
L2Z35_RS17525	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z35_RS17530	COG2814	Major facilitator Superfamily
L2Z35_RS17565	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2Z35_RS17565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z35_RS17570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z35_RS17580	COG1012	belongs to the aldehyde dehydrogenase family
L2Z35_RS17590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z35_RS17595	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z35_RS17600	COG0583	DNA-binding transcription factor activity
L2Z35_RS17605	COG1113	amino acid transport
L2Z35_RS17625	COG2508	Transcriptional regulator
L2Z35_RS17625	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L2Z35_RS17660	COG2879	small protein
L2Z35_RS17665	COG1966	Carbon starvation protein
L2Z35_RS17710	COG1067	ATP-dependent peptidase activity
L2Z35_RS17715	COG0583	DNA-binding transcription factor activity
L2Z35_RS17740	COG1686	Belongs to the peptidase S11 family
L2Z35_RS17745	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Z35_RS17775	COG3328	transposase activity
L2Z35_RS17785	COG0616	signal peptide processing
L2Z35_RS17790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Z35_RS17800	COG0573	inorganic phosphate transmembrane transporter activity
L2Z35_RS17805	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Z35_RS17810	COG1113	amino acid transport
L2Z35_RS17815	COG3961	Belongs to the TPP enzyme family
L2Z35_RS17820	COG1522	sequence-specific DNA binding
L2Z35_RS17830	COG0076	glutamate decarboxylase activity
L2Z35_RS17835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z35_RS17845	COG1309	transcriptional regulator
L2Z35_RS17860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z35_RS17895	COG0352	thiamine-phosphate diphosphorylase activity
L2Z35_RS17920	COG0612	Peptidase, M16
L2Z35_RS17930	COG1823	symporter activity
L2Z35_RS17935	COG0583	DNA-binding transcription factor activity
L2Z35_RS17940	COG0477	Major facilitator Superfamily
L2Z35_RS17965	COG1187	pseudouridine synthase activity
L2Z35_RS17980	COG1686	Belongs to the peptidase S11 family
L2Z35_RS17985	COG1252	NADH dehydrogenase
L2Z35_RS17995	COG0415	Belongs to the DNA photolyase family
L2Z35_RS18010	COG1215	transferase activity, transferring glycosyl groups
L2Z35_RS18040	COG2070	2-Nitropropane dioxygenase
L2Z35_RS18095	COG0556	nucleotide-excision repair
L2Z35_RS18115	COG0436	Aminotransferase
L2Z35_RS18145	COG4221	oxidoreductase activity
L2Z35_RS18155	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Z35_RS18160	COG1381	Involved in DNA repair and RecF pathway recombination
L2Z35_RS18170	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Z35_RS18185	COG0681	Belongs to the peptidase S26 family
L2Z35_RS18200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z35_RS18220	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Z35_RS18225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2Z35_RS18230	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2Z35_RS18240	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2Z35_RS18245	COG4208	sulfate ABC transporter
L2Z35_RS18250	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2Z35_RS18255	COG0583	DNA-binding transcription factor activity
L2Z35_RS18260	COG4625	pathogenesis
L2Z35_RS18275	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2Z35_RS18290	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Z35_RS18300	COG1056	cytidyltransferase-related domain
L2Z35_RS18300	COG1051	belongs to the nudix hydrolase family
L2Z35_RS18305	COG1024	Enoyl-CoA hydratase
L2Z35_RS18315	COG2814	Major facilitator Superfamily
L2Z35_RS18320	COG0047	phosphoribosylformylglycinamidine synthase activity
L2Z35_RS18320	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2Z35_RS18340	COG1473	amidohydrolase
L2Z35_RS18345	COG0824	Thioesterase
L2Z35_RS18365	COG0823	Involved in the tonB-independent uptake of proteins
L2Z35_RS18385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z35_RS18420	COG0628	permease
L2Z35_RS18430	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Z35_RS18435	COG0596	Alpha beta hydrolase
L2Z35_RS18440	COG0616	signal peptide processing
L2Z35_RS18440	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Z35_RS18450	COG0658	competence protein
L2Z35_RS18450	COG2333	competence protein COMEC
L2Z35_RS18455	COG1136	(ABC) transporter
L2Z35_RS18460	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Z35_RS18495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z35_RS18515	COG0463	Glycosyl transferase, family 2
L2Z35_RS18545	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z35_RS18550	COG1280	lysine exporter protein (LysE YggA)
L2Z35_RS18560	COG0019	diaminopimelate decarboxylase activity
L2Z35_RS18570	COG1113	amino acid transport
L2Z35_RS18585	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Z35_RS18595	COG3339	Conserved Protein
L2Z35_RS18600	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2Z35_RS18605	COG0243	molybdopterin cofactor binding
L2Z35_RS18610	COG1929	Belongs to the glycerate kinase type-1 family
L2Z35_RS18625	COG0778	Nitroreductase
L2Z35_RS18660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z35_RS18675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z35_RS18695	COG0741	lytic transglycosylase activity
L2Z35_RS18715	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z35_RS18745	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z35_RS18750	COG1597	lipid kinase activity
L2Z35_RS18765	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2Z35_RS18770	COG0477	Major facilitator Superfamily
L2Z35_RS18820	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Z35_RS18825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z35_RS18850	COG0505	Belongs to the CarA family
L2Z35_RS18870	COG0589	response to stress
L2Z35_RS18885	COG2843	Capsule synthesis protein
L2Z35_RS18905	COG2321	neutral zinc metallopeptidase
L2Z35_RS18910	COG2354	Protein conserved in bacteria
L2Z35_RS18930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z35_RS18955	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Z35_RS18960	COG1053	succinate dehydrogenase
L2Z35_RS18965	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Z35_RS18970	COG2009	succinate dehydrogenase
L2Z35_RS19010	COG2921	Belongs to the UPF0250 family
L2Z35_RS19015	COG0321	lipoyl(octanoyl) transferase activity
L2Z35_RS19030	COG0531	amino acid
L2Z35_RS19040	COG1733	regulation of RNA biosynthetic process
L2Z35_RS19045	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Z35_RS19050	COG1648	precorrin-2 dehydrogenase activity
L2Z35_RS19050	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Z35_RS19065	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Z35_RS19095	COG0671	phosphoesterase, PA-phosphatase related
L2Z35_RS19100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z35_RS19110	COG1538	Outer membrane efflux protein
L2Z35_RS19115	COG0393	Putative heavy-metal-binding
L2Z35_RS19120	COG0393	Putative heavy-metal-binding
L2Z35_RS19130	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z35_RS19140	COG0525	valine-tRNA ligase activity
L2Z35_RS19160	COG0583	DNA-binding transcription factor activity
L2Z35_RS19165	COG0004	ammonium transporteR
L2Z35_RS19175	COG0642	Histidine kinase
L2Z35_RS19180	COG0745	RESPONSE REGULATOR receiver
L2Z35_RS19185	COG2194	sulfuric ester hydrolase activity
L2Z35_RS19205	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z35_RS19220	COG2315	Protein conserved in bacteria
L2Z35_RS19225	COG0142	geranyltranstransferase activity
L2Z35_RS19230	COG2828	Protein conserved in bacteria
L2Z35_RS19235	COG1113	amino acid transport
L2Z35_RS19245	COG0582	viral genome integration into host DNA
L2Z35_RS19380	COG3676	manually curated