locus-tag	class	description
L2Z39_RS00035	COG4695	Portal protein
L2Z39_RS00095	COG0739	heme binding
L2Z39_RS00095	COG0741	lytic transglycosylase activity
L2Z39_RS00095	COG1196	nuclear chromosome segregation
L2Z39_RS00180	COG0006	proline dipeptidase activity
L2Z39_RS00185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z39_RS00190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z39_RS00210	COG1279	arginine transmembrane transporter activity
L2Z39_RS00215	COG0583	DNA-binding transcription factor activity
L2Z39_RS00255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z39_RS00260	COG1388	LysM domain
L2Z39_RS00260	COG1388	LysM domain
L2Z39_RS00260	COG0741	lytic transglycosylase activity
L2Z39_RS00260	COG0741	lytic transglycosylase activity
L2Z39_RS00270	COG4174	ABC transporter (Permease)
L2Z39_RS00275	COG4239	(ABC) transporter, permease
L2Z39_RS00280	COG4172	Belongs to the ABC transporter superfamily
L2Z39_RS00300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z39_RS00310	COG3706	GGDEF domain
L2Z39_RS00310	COG2203	Gaf domain
L2Z39_RS00310	COG4251	negative regulation of phosphorylation
L2Z39_RS00310	COG5001	Diguanylate cyclase
L2Z39_RS00320	COG1902	pentaerythritol trinitrate reductase activity
L2Z39_RS00320	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z39_RS00340	COG3328	transposase activity
L2Z39_RS00405	COG3121	Chaperone
L2Z39_RS00410	COG3188	usher protein
L2Z39_RS00435	COG4269	membrane
L2Z39_RS00475	COG0300	oxidoreductase activity
L2Z39_RS00485	COG1309	transcriptional regulator
L2Z39_RS00490	COG1741	Belongs to the pirin family
L2Z39_RS00505	COG2072	flavoprotein involved in K transport
L2Z39_RS00515	COG2252	PERMEase
L2Z39_RS00520	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2Z39_RS00525	COG3038	cytochrome b561
L2Z39_RS00535	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2Z39_RS00545	COG0527	aspartate kinase activity
L2Z39_RS00555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Z39_RS00565	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Z39_RS00580	COG0667	Aldo Keto reductase
L2Z39_RS00600	COG1765	OsmC-like protein
L2Z39_RS00615	COG0542	response to heat
L2Z39_RS00650	COG2885	chlorophyll binding
L2Z39_RS00660	COG0625	glutathione transferase activity
L2Z39_RS00665	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2Z39_RS00685	COG3634	alkyl hydroperoxide reductase activity
L2Z39_RS00695	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2Z39_RS00705	COG0450	alkyl hydroperoxide reductase
L2Z39_RS00710	COG1643	Atp-dependent helicase
L2Z39_RS00725	COG2814	Major facilitator Superfamily
L2Z39_RS00730	COG3135	benzoate transporter
L2Z39_RS00735	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z39_RS00740	COG0633	Ferredoxin
L2Z39_RS00740	COG0543	2 iron, 2 sulfur cluster binding
L2Z39_RS00745	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z39_RS00750	COG4638	Rieske (2fe-2S)
L2Z39_RS00760	COG0583	DNA-binding transcription factor activity
L2Z39_RS00810	COG1570	exodeoxyribonuclease VII activity
L2Z39_RS00845	COG1278	Cold shock
L2Z39_RS00880	COG2814	Major facilitator Superfamily
L2Z39_RS00945	COG0517	IMP dehydrogenase activity
L2Z39_RS00945	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L2Z39_RS00950	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Z39_RS00960	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2Z39_RS00965	COG1137	ATPase activity
L2Z39_RS00970	COG1538	Outer membrane efflux protein
L2Z39_RS01000	COG4122	O-methyltransferase activity
L2Z39_RS01010	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2Z39_RS01040	COG1560	Kdo2-lipid A biosynthetic process
L2Z39_RS01055	COG2814	Major facilitator Superfamily
L2Z39_RS01080	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z39_RS01165	COG3209	COG3209 Rhs family protein
L2Z39_RS01230	COG0583	DNA-binding transcription factor activity
L2Z39_RS01235	COG1914	H( )-stimulated, divalent metal cation uptake system
L2Z39_RS01255	COG4770	biotin carboxylase activity
L2Z39_RS01260	COG0038	chloride channel
L2Z39_RS01265	COG2831	hemolysin activation secretion protein
L2Z39_RS01270	COG3210	domain, Protein
L2Z39_RS01290	COG1309	transcriptional regulator
L2Z39_RS01300	COG1063	alcohol dehydrogenase
L2Z39_RS01320	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z39_RS01430	COG0590	tRNA wobble adenosine to inosine editing
L2Z39_RS01435	COG2807	transmembrane transport
L2Z39_RS01450	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2Z39_RS01460	COG0789	Transcriptional regulator
L2Z39_RS01470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z39_RS01490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z39_RS01515	COG1012	belongs to the aldehyde dehydrogenase family
L2Z39_RS01520	COG0531	amino acid
L2Z39_RS01525	COG1760	l-serine dehydratase
L2Z39_RS01530	COG2030	dehydratase
L2Z39_RS01530	COG1012	belongs to the aldehyde dehydrogenase family
L2Z39_RS01535	COG3396	Phenylacetate-CoA oxygenase
L2Z39_RS01540	COG3460	Phenylacetate-CoA oxygenase
L2Z39_RS01545	COG3396	Phenylacetate-CoA oxygenase
L2Z39_RS01550	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Z39_RS01555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z39_RS01560	COG1024	Enoyl-CoA hydratase
L2Z39_RS01565	COG1024	Enoyl-CoA hydratase
L2Z39_RS01570	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z39_RS01580	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L2Z39_RS01585	COG3327	negative regulation of DNA-templated transcription, initiation
L2Z39_RS01595	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z39_RS01630	COG2207	Transcriptional regulator
L2Z39_RS01645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z39_RS01650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z39_RS01655	COG2271	Major facilitator Superfamily
L2Z39_RS01660	COG0753	catalase activity
L2Z39_RS01665	COG3038	cytochrome b561
L2Z39_RS01670	COG0583	DNA-binding transcription factor activity
L2Z39_RS01680	COG1414	Transcriptional regulator
L2Z39_RS01685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z39_RS01700	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Z39_RS01705	COG3842	ATPase activity
L2Z39_RS01720	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Z39_RS01725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z39_RS01730	COG2814	Major facilitator Superfamily
L2Z39_RS01735	COG1960	acyl-CoA dehydrogenase activity
L2Z39_RS01750	COG1024	Enoyl-CoA hydratase
L2Z39_RS01765	COG2814	Major facilitator Superfamily
L2Z39_RS01775	COG0183	Belongs to the thiolase family
L2Z39_RS01780	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z39_RS01785	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z39_RS01790	COG1024	Enoyl-CoA hydratase
L2Z39_RS01795	COG1960	acyl-CoA dehydrogenase activity
L2Z39_RS01800	COG2814	Major facilitator Superfamily
L2Z39_RS01805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z39_RS01810	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z39_RS01820	COG2814	Major facilitator Superfamily
L2Z39_RS01830	COG1960	acyl-CoA dehydrogenase activity
L2Z39_RS01845	COG0583	DNA-binding transcription factor activity
L2Z39_RS01855	COG4770	biotin carboxylase activity
L2Z39_RS01860	COG1024	Enoyl-CoA hydratase
L2Z39_RS01865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z39_RS01870	COG1960	acyl-CoA dehydrogenase activity
L2Z39_RS01875	COG1309	transcriptional regulator
L2Z39_RS01880	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z39_RS01900	COG0583	DNA-binding transcription factor activity
L2Z39_RS01950	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z39_RS01975	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Z39_RS01995	COG0784	Response regulator, receiver
L2Z39_RS01995	COG2205	protein histidine kinase activity
L2Z39_RS02015	COG0765	amino acid transport
L2Z39_RS02020	COG0765	amino acid transport
L2Z39_RS02025	COG1126	abc transporter atp-binding protein
L2Z39_RS02030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z39_RS02035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z39_RS02050	COG1280	lysine exporter protein (LysE YggA)
L2Z39_RS02060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2Z39_RS02065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z39_RS02070	COG1045	serine acetyltransferase
L2Z39_RS02085	COG0583	DNA-binding transcription factor activity
L2Z39_RS02090	COG0625	glutathione transferase activity
L2Z39_RS02095	COG0625	glutathione transferase activity
L2Z39_RS02100	COG0583	DNA-binding transcription factor activity
L2Z39_RS02110	COG1346	cytolysis
L2Z39_RS02130	COG2814	Major facilitator Superfamily
L2Z39_RS02140	COG0583	DNA-binding transcription factor activity
L2Z39_RS02150	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2Z39_RS02155	COG3052	prosthetic group binding
L2Z39_RS02175	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Z39_RS02195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z39_RS02205	COG1294	oxidase, subunit
L2Z39_RS02210	COG1271	oxidase subunit
L2Z39_RS02230	COG0477	Major facilitator Superfamily
L2Z39_RS02240	COG4521	taurine ABC transporter
L2Z39_RS02245	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2Z39_RS02250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z39_RS02255	COG2175	clavaminate synthase activity
L2Z39_RS02265	COG1953	Uracil, thiamine, allantoin
L2Z39_RS02275	COG0583	DNA-binding transcription factor activity
L2Z39_RS02300	COG0640	Transcriptional regulator
L2Z39_RS02305	COG0798	PFAM Bile acid sodium symporter
L2Z39_RS02310	COG0583	DNA-binding transcription factor activity
L2Z39_RS02325	COG3634	alkyl hydroperoxide reductase activity
L2Z39_RS02360	COG1301	dicarboxylic acid transport
L2Z39_RS02365	COG0436	Aminotransferase
L2Z39_RS02375	COG0386	Belongs to the glutathione peroxidase family
L2Z39_RS02415	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z39_RS02440	COG0012	GTP binding
L2Z39_RS02445	COG2011	ABC-type metal ion transport system permease component
L2Z39_RS02450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z39_RS02460	COG1464	Belongs to the NlpA lipoprotein family
L2Z39_RS02490	COG0765	amino acid transport
L2Z39_RS02495	COG0765	amino acid transport
L2Z39_RS02500	COG1126	abc transporter atp-binding protein
L2Z39_RS02510	COG1522	sequence-specific DNA binding
L2Z39_RS02525	COG1309	transcriptional regulator
L2Z39_RS02545	COG0583	DNA-binding transcription factor activity
L2Z39_RS02555	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z39_RS02565	COG0697	spore germination
L2Z39_RS02595	COG3121	Chaperone
L2Z39_RS02600	COG3539	Fimbrial protein
L2Z39_RS02625	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Z39_RS02625	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Z39_RS02670	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Z39_RS02680	COG2353	YceI-like domain
L2Z39_RS02690	COG3698	Phosphodiester glycosidase
L2Z39_RS02705	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2Z39_RS02710	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z39_RS02710	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z39_RS02710	COG0506	proline dehydrogenase activity
L2Z39_RS02720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z39_RS02725	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Z39_RS02745	COG1132	(ABC) transporter
L2Z39_RS02750	COG3122	Protein conserved in bacteria
L2Z39_RS02755	COG3619	membrane
L2Z39_RS02765	COG0640	Transcriptional regulator
L2Z39_RS02775	COG2850	peptidyl-arginine hydroxylation
L2Z39_RS02780	COG0424	maF-like protein
L2Z39_RS02800	COG0191	fructose-bisphosphate aldolase activity
L2Z39_RS02805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z39_RS02820	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z39_RS02830	COG1192	Involved in chromosome partitioning
L2Z39_RS02835	COG1475	DNA binding
L2Z39_RS02840	COG0811	peptide transport
L2Z39_RS02850	COG1132	(ABC) transporter
L2Z39_RS02855	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Z39_RS02875	COG0084	hydrolase, TatD family'
L2Z39_RS02940	COG0776	regulation of translation
L2Z39_RS02970	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Z39_RS02975	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Z39_RS03000	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
L2Z39_RS03020	COG0339	signal peptide processing
L2Z39_RS03030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Z39_RS03065	COG0702	epimerase
L2Z39_RS03070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z39_RS03090	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Z39_RS03120	COG0316	Belongs to the HesB IscA family
L2Z39_RS03125	COG0822	iron-sulfur transferase activity
L2Z39_RS03150	COG0776	regulation of translation
L2Z39_RS03155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z39_RS03160	COG2207	Transcriptional regulator
L2Z39_RS03165	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z39_RS03170	COG1960	acyl-CoA dehydrogenase activity
L2Z39_RS03175	COG1960	acyl-CoA dehydrogenase activity
L2Z39_RS03190	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Z39_RS03210	COG4264	IucA IucC family
L2Z39_RS03215	COG4264	IucA IucC family
L2Z39_RS03225	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z39_RS03255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z39_RS03275	COG0406	alpha-ribazole phosphatase activity
L2Z39_RS03290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Z39_RS03295	COG0730	response to heat
L2Z39_RS03315	COG4773	Receptor
L2Z39_RS03320	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z39_RS03335	COG1131	(ABC) transporter
L2Z39_RS03340	COG0842	Transport permease protein
L2Z39_RS03345	COG0842	Transport permease protein
L2Z39_RS03400	COG2226	methyltransferase
L2Z39_RS03425	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Z39_RS03460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z39_RS03470	COG0133	tryptophan synthase activity
L2Z39_RS03485	COG3706	GGDEF domain
L2Z39_RS03500	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z39_RS03505	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2Z39_RS03510	COG0022	dehydrogenase e1 component
L2Z39_RS03515	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z39_RS03520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z39_RS03530	COG1063	alcohol dehydrogenase
L2Z39_RS03535	COG3781	membrane
L2Z39_RS03545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z39_RS03545	COG3453	Protein conserved in bacteria
L2Z39_RS03560	COG0730	response to heat
L2Z39_RS03575	COG3708	Transcriptional regulator
L2Z39_RS03575	COG2207	Transcriptional regulator
L2Z39_RS03580	COG1733	regulation of RNA biosynthetic process
L2Z39_RS03585	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Z39_RS03595	COG2188	Transcriptional regulator
L2Z39_RS03610	COG4521	taurine ABC transporter
L2Z39_RS03615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z39_RS03635	COG0477	Major facilitator Superfamily
L2Z39_RS03645	COG1027	Aspartate ammonia-lyase
L2Z39_RS03660	COG0583	DNA-binding transcription factor activity
L2Z39_RS03665	COG0583	DNA-binding transcription factor activity
L2Z39_RS03670	COG0183	Belongs to the thiolase family
L2Z39_RS03675	COG2031	fatty acid transporter
L2Z39_RS03690	COG0583	DNA-binding transcription factor activity
L2Z39_RS03700	COG2610	gluconate transmembrane transporter activity
L2Z39_RS03705	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z39_RS03710	COG2207	Transcriptional regulator
L2Z39_RS03725	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z39_RS03735	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z39_RS03750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z39_RS03750	COG0543	2 iron, 2 sulfur cluster binding
L2Z39_RS03755	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z39_RS03760	COG4638	Rieske (2fe-2S)
L2Z39_RS03770	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2Z39_RS03775	COG4149	molybdate abc transporter
L2Z39_RS03780	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2Z39_RS03785	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z39_RS03790	COG1535	isochorismatase
L2Z39_RS03790	COG3433	isochorismatase activity
L2Z39_RS03850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z39_RS03865	COG0753	catalase activity
L2Z39_RS03875	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L2Z39_RS03900	COG3539	Fimbrial protein
L2Z39_RS03975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z39_RS03995	COG2072	flavoprotein involved in K transport
L2Z39_RS04005	COG1538	Outer membrane efflux protein
L2Z39_RS04010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z39_RS04015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z39_RS04020	COG0745	RESPONSE REGULATOR receiver
L2Z39_RS04025	COG2205	protein histidine kinase activity
L2Z39_RS04045	COG2207	Transcriptional regulator
L2Z39_RS04070	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z39_RS04120	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2Z39_RS04240	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z39_RS04260	COG1120	ATPase activity
L2Z39_RS04265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z39_RS04275	COG1064	alcohol dehydrogenase
L2Z39_RS04290	COG2207	Transcriptional regulator
L2Z39_RS04295	COG2084	Dehydrogenase
L2Z39_RS04305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z39_RS04310	COG0583	DNA-binding transcription factor activity
L2Z39_RS04320	COG0129	dihydroxy-acid dehydratase activity
L2Z39_RS04325	COG1012	belongs to the aldehyde dehydrogenase family
L2Z39_RS04340	COG1566	PFAM secretion protein HlyD family protein
L2Z39_RS04370	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z39_RS04400	COG0583	DNA-binding transcription factor activity
L2Z39_RS04415	COG2188	Transcriptional regulator
L2Z39_RS04445	COG3210	domain, Protein
L2Z39_RS04450	COG2831	hemolysin activation secretion protein
L2Z39_RS04460	COG1473	amidohydrolase
L2Z39_RS04470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z39_RS04470	COG0475	glutathione-regulated potassium exporter activity
L2Z39_RS04480	COG0583	DNA-binding transcription factor activity
L2Z39_RS04490	COG1335	isochorismatase
L2Z39_RS04500	COG1309	transcriptional regulator
L2Z39_RS04530	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L2Z39_RS04540	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z39_RS04540	COG1902	pentaerythritol trinitrate reductase activity
L2Z39_RS04545	COG1846	Transcriptional regulator
L2Z39_RS04565	COG0753	catalase activity
L2Z39_RS04580	COG1012	belongs to the aldehyde dehydrogenase family
L2Z39_RS04595	COG3162	membrane
L2Z39_RS04610	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z39_RS04615	COG1960	acyl-CoA dehydrogenase activity
L2Z39_RS04635	COG1012	belongs to the aldehyde dehydrogenase family
L2Z39_RS04655	COG2186	Transcriptional regulator
L2Z39_RS04665	COG0583	DNA-binding transcription factor activity
L2Z39_RS04670	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z39_RS04675	COG4829	muconolactone delta-isomerase
L2Z39_RS04685	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z39_RS04690	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z39_RS04695	COG0183	Belongs to the thiolase family
L2Z39_RS04700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z39_RS04710	COG1012	belongs to the aldehyde dehydrogenase family
L2Z39_RS04720	COG3733	amine oxidase
L2Z39_RS04730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z39_RS04740	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z39_RS04750	COG4638	Rieske (2fe-2S)
L2Z39_RS04770	COG0154	amidase activity
L2Z39_RS04780	COG2814	Major facilitator Superfamily
L2Z39_RS04805	COG1960	acyl-CoA dehydrogenase activity
L2Z39_RS04810	COG0583	DNA-binding transcription factor activity
L2Z39_RS04815	COG1414	Transcriptional regulator
L2Z39_RS04830	COG2391	methyltransferase activity
L2Z39_RS04840	COG4993	Dehydrogenase
L2Z39_RS04845	COG3659	wide pore channel activity
L2Z39_RS04850	COG3420	alginic acid biosynthetic process
L2Z39_RS04855	COG0710	3-dehydroquinate dehydratase activity
L2Z39_RS04860	COG3485	protocatechuate 3,4-dioxygenase
L2Z39_RS04865	COG3485	protocatechuate 3,4-dioxygenase
L2Z39_RS04870	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z39_RS04875	COG2271	Major facilitator Superfamily
L2Z39_RS04880	COG0596	Alpha beta hydrolase
L2Z39_RS04885	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Z39_RS04890	COG0183	Belongs to the thiolase family
L2Z39_RS04895	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z39_RS04900	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z39_RS04910	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Z39_RS04915	COG2323	membrane
L2Z39_RS04960	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z39_RS04960	COG1902	pentaerythritol trinitrate reductase activity
L2Z39_RS04985	COG0542	response to heat
L2Z39_RS04990	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Z39_RS05020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z39_RS05025	COG0569	domain protein
L2Z39_RS05030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Z39_RS05045	COG4774	siderophore transport
L2Z39_RS05050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Z39_RS05060	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2Z39_RS05075	COG1294	oxidase, subunit
L2Z39_RS05080	COG4890	Cyd operon protein YbgT
L2Z39_RS05095	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2Z39_RS05105	COG0552	protein localization to endoplasmic reticulum
L2Z39_RS05130	COG0516	GMP reductase activity
L2Z39_RS05130	COG0517	IMP dehydrogenase activity
L2Z39_RS05135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z39_RS05140	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Z39_RS05150	COG0583	DNA-binding transcription factor activity
L2Z39_RS05155	COG0024	Methionine aminopeptidase
L2Z39_RS05185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Z39_RS05185	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z39_RS05190	COG1105	Belongs to the carbohydrate kinase PfkB family
L2Z39_RS05195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z39_RS05195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z39_RS05195	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2Z39_RS05260	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Z39_RS05270	COG2137	regulation of response to DNA damage stimulus
L2Z39_RS05285	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z39_RS05320	COG0575	Belongs to the CDS family
L2Z39_RS05325	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Z39_RS05345	COG3852	Histidine kinase
L2Z39_RS05350	COG2204	response regulator
L2Z39_RS05405	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z39_RS05410	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Z39_RS05435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z39_RS05445	COG0303	'Molybdopterin
L2Z39_RS05450	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Z39_RS05450	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Z39_RS05465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Z39_RS05470	COG0243	molybdopterin cofactor binding
L2Z39_RS05480	COG0243	molybdopterin cofactor binding
L2Z39_RS05485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z39_RS05490	COG2146	nitrite reductase [NAD(P)H] activity
L2Z39_RS05490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z39_RS05500	COG0745	RESPONSE REGULATOR receiver
L2Z39_RS05505	COG1116	anion transmembrane transporter activity
L2Z39_RS05505	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z39_RS05525	COG0511	ligase activity, forming carbon-carbon bonds
L2Z39_RS05540	COG2814	Major facilitator Superfamily
L2Z39_RS05560	COG0069	glutamate synthase activity
L2Z39_RS05580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Z39_RS05590	COG1454	alcohol dehydrogenase
L2Z39_RS05595	COG0824	Thioesterase
L2Z39_RS05605	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z39_RS05620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z39_RS05625	COG2030	dehydratase
L2Z39_RS05635	COG0183	Belongs to the thiolase family
L2Z39_RS05645	COG0583	DNA-binding transcription factor activity
L2Z39_RS05650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z39_RS05660	COG1522	sequence-specific DNA binding
L2Z39_RS05665	COG3135	benzoate transporter
L2Z39_RS05675	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Z39_RS05700	COG0589	response to stress
L2Z39_RS05705	COG0488	(ABC) transporter
L2Z39_RS05725	COG4773	Receptor
L2Z39_RS05760	COG0668	transmembrane transport
L2Z39_RS05770	COG1309	transcriptional regulator
L2Z39_RS05790	COG1605	Chorismate mutase
L2Z39_RS05800	COG4221	oxidoreductase activity
L2Z39_RS05810	COG0308	aminopeptidase N
L2Z39_RS05830	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
L2Z39_RS05840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z39_RS05845	COG1454	alcohol dehydrogenase
L2Z39_RS05865	COG0531	amino acid
L2Z39_RS05870	COG4303	Ethanolamine ammonia lyase large subunit
L2Z39_RS05875	COG4302	ethanolamine ammonia-lyase activity
L2Z39_RS05880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z39_RS05880	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z39_RS05885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z39_RS05895	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z39_RS05910	COG0697	spore germination
L2Z39_RS05915	COG1923	regulation of RNA biosynthetic process
L2Z39_RS05925	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Z39_RS05930	COG0802	atpase or kinase
L2Z39_RS05950	COG1187	pseudouridine synthase activity
L2Z39_RS05965	COG0583	DNA-binding transcription factor activity
L2Z39_RS05980	COG2814	Major facilitator Superfamily
L2Z39_RS05985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z39_RS06010	COG0729	surface antigen
L2Z39_RS06030	COG0174	glutamine synthetase
L2Z39_RS06035	COG0745	RESPONSE REGULATOR receiver
L2Z39_RS06040	COG2205	protein histidine kinase activity
L2Z39_RS06050	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2Z39_RS06055	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2Z39_RS06080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z39_RS06085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z39_RS06090	COG1960	acyl-CoA dehydrogenase activity
L2Z39_RS06105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z39_RS06110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z39_RS06130	COG0583	DNA-binding transcription factor activity
L2Z39_RS06145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z39_RS06155	COG3658	cytochrome
L2Z39_RS06160	COG1215	transferase activity, transferring glycosyl groups
L2Z39_RS06165	COG0726	polysaccharide deacetylase
L2Z39_RS06165	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z39_RS06190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Z39_RS06195	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Z39_RS06205	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2Z39_RS06230	COG0305	Participates in initiation and elongation during chromosome replication
L2Z39_RS06235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Z39_RS06245	COG1305	Transglutaminase-like
L2Z39_RS06255	COG2308	Evidence 4 Homologs of previously reported genes of
L2Z39_RS06285	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Z39_RS06290	COG0138	bifunctional purine biosynthesis protein purh
L2Z39_RS06295	COG0151	Belongs to the GarS family
L2Z39_RS06300	COG1464	Belongs to the NlpA lipoprotein family
L2Z39_RS06305	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z39_RS06310	COG2011	ABC-type metal ion transport system permease component
L2Z39_RS06315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z39_RS06325	COG1301	dicarboxylic acid transport
L2Z39_RS06365	COG2433	Pfam Transposase IS66
L2Z39_RS06375	COG3173	Aminoglycoside phosphotransferase
L2Z39_RS06380	COG0488	(ABC) transporter
L2Z39_RS06495	COG2186	Transcriptional regulator
L2Z39_RS06505	COG0786	glutamate:sodium symporter activity
L2Z39_RS06510	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Z39_RS06535	COG3111	PFAM Bacterial OB fold (BOF) protein
L2Z39_RS06635	COG1610	YqeY-like protein
L2Z39_RS06640	COG4783	chaperone-mediated protein folding
L2Z39_RS06665	COG1286	toxin biosynthetic process
L2Z39_RS06695	COG0778	Nitroreductase
L2Z39_RS06705	COG0513	Belongs to the DEAD box helicase family
L2Z39_RS06730	COG2363	Small membrane protein
L2Z39_RS06760	COG1234	tRNA 3'-trailer cleavage
L2Z39_RS06765	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2Z39_RS06775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Z39_RS06785	COG2819	hydrolase of the alpha beta superfamily
L2Z39_RS06790	COG1960	acyl-CoA dehydrogenase activity
L2Z39_RS06795	COG1301	dicarboxylic acid transport
L2Z39_RS06800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Z39_RS06805	COG3139	Protein of unknown function (DUF1315)
L2Z39_RS06810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Z39_RS06815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Z39_RS06825	COG0494	nUDIX hydrolase
L2Z39_RS06835	COG0642	Histidine kinase
L2Z39_RS06850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Z39_RS06860	COG1720	tRNA m6t6A37 methyltransferase activity
L2Z39_RS06875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z39_RS06880	COG0826	peptidase U32
L2Z39_RS06885	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z39_RS06895	COG4598	ABC transporter
L2Z39_RS06900	COG4160	amino acid transport
L2Z39_RS06905	COG4215	(ABC) transporter
L2Z39_RS06920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z39_RS06965	COG1131	(ABC) transporter
L2Z39_RS06970	COG0842	Transport permease protein
L2Z39_RS06985	COG0772	Belongs to the SEDS family
L2Z39_RS06990	COG2951	lytic endotransglycosylase activity
L2Z39_RS07015	COG2207	Transcriptional regulator
L2Z39_RS07030	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Z39_RS07035	COG0024	Methionine aminopeptidase
L2Z39_RS07045	COG2223	nitrite transmembrane transporter activity
L2Z39_RS07055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z39_RS07060	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z39_RS07065	COG1960	acyl-CoA dehydrogenase activity
L2Z39_RS07080	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Z39_RS07085	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Z39_RS07090	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z39_RS07110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z39_RS07115	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2Z39_RS07120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Z39_RS07155	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Z39_RS07165	COG0174	glutamine synthetase
L2Z39_RS07180	COG0512	Glutamine amidotransferase of anthranilate synthase
L2Z39_RS07185	COG0308	aminopeptidase N
L2Z39_RS07215	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2Z39_RS07225	COG0302	gtp cyclohydrolase
L2Z39_RS07250	COG3739	integral membrane protein
L2Z39_RS07265	COG1169	isochorismate synthase
L2Z39_RS07275	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z39_RS07280	COG1132	(ABC) transporter
L2Z39_RS07285	COG1132	(ABC) transporter
L2Z39_RS07300	COG3433	isochorismatase activity
L2Z39_RS07300	COG1535	isochorismatase
L2Z39_RS07305	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z39_RS07310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z39_RS07320	COG4774	siderophore transport
L2Z39_RS07325	COG4607	ABC-type enterochelin transport system periplasmic component
L2Z39_RS07330	COG4604	ABC transporter, ATP-binding protein
L2Z39_RS07335	COG4605	iron ion homeostasis
L2Z39_RS07340	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z39_RS07345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z39_RS07360	COG2964	Protein conserved in bacteria
L2Z39_RS07370	COG1741	Belongs to the pirin family
L2Z39_RS07390	COG1309	transcriptional regulator
L2Z39_RS07400	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z39_RS07405	COG2814	Major facilitator Superfamily
L2Z39_RS07440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z39_RS07440	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2Z39_RS07445	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z39_RS07455	COG1012	belongs to the aldehyde dehydrogenase family
L2Z39_RS07475	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z39_RS07480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z39_RS07485	COG0583	DNA-binding transcription factor activity
L2Z39_RS07490	COG1113	amino acid transport
L2Z39_RS07510	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L2Z39_RS07510	COG2508	Transcriptional regulator
L2Z39_RS07545	COG2879	small protein
L2Z39_RS07550	COG1966	Carbon starvation protein
L2Z39_RS07605	COG1067	ATP-dependent peptidase activity
L2Z39_RS07610	COG0583	DNA-binding transcription factor activity
L2Z39_RS07635	COG1686	Belongs to the peptidase S11 family
L2Z39_RS07640	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Z39_RS07675	COG0616	signal peptide processing
L2Z39_RS07680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Z39_RS07690	COG0573	inorganic phosphate transmembrane transporter activity
L2Z39_RS07695	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Z39_RS07700	COG1113	amino acid transport
L2Z39_RS07705	COG3961	Belongs to the TPP enzyme family
L2Z39_RS07710	COG1522	sequence-specific DNA binding
L2Z39_RS07720	COG0076	glutamate decarboxylase activity
L2Z39_RS07725	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z39_RS07735	COG1309	transcriptional regulator
L2Z39_RS07750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z39_RS07785	COG0352	thiamine-phosphate diphosphorylase activity
L2Z39_RS07810	COG0612	Peptidase, M16
L2Z39_RS07820	COG1823	symporter activity
L2Z39_RS07825	COG0583	DNA-binding transcription factor activity
L2Z39_RS07830	COG0477	Major facilitator Superfamily
L2Z39_RS07860	COG1061	Type III restriction enzyme res subunit
L2Z39_RS07865	COG1002	Type II restriction enzyme, methylase subunits
L2Z39_RS07885	COG1187	pseudouridine synthase activity
L2Z39_RS07900	COG1686	Belongs to the peptidase S11 family
L2Z39_RS07905	COG1252	NADH dehydrogenase
L2Z39_RS07915	COG0415	Belongs to the DNA photolyase family
L2Z39_RS07970	COG2070	2-Nitropropane dioxygenase
L2Z39_RS08025	COG0556	nucleotide-excision repair
L2Z39_RS08045	COG0436	Aminotransferase
L2Z39_RS08075	COG4221	oxidoreductase activity
L2Z39_RS08085	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Z39_RS08090	COG1381	Involved in DNA repair and RecF pathway recombination
L2Z39_RS08100	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Z39_RS08115	COG0681	Belongs to the peptidase S26 family
L2Z39_RS08130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z39_RS08150	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Z39_RS08155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2Z39_RS08160	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2Z39_RS08170	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2Z39_RS08175	COG4208	sulfate ABC transporter
L2Z39_RS08180	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2Z39_RS08185	COG0583	DNA-binding transcription factor activity
L2Z39_RS08190	COG4625	pathogenesis
L2Z39_RS08205	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2Z39_RS08220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Z39_RS08230	COG1051	belongs to the nudix hydrolase family
L2Z39_RS08230	COG1056	cytidyltransferase-related domain
L2Z39_RS08235	COG1024	Enoyl-CoA hydratase
L2Z39_RS08245	COG2814	Major facilitator Superfamily
L2Z39_RS08250	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2Z39_RS08250	COG0047	phosphoribosylformylglycinamidine synthase activity
L2Z39_RS08270	COG1473	amidohydrolase
L2Z39_RS08275	COG0824	Thioesterase
L2Z39_RS08295	COG0823	Involved in the tonB-independent uptake of proteins
L2Z39_RS08315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z39_RS08355	COG0628	permease
L2Z39_RS08365	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Z39_RS08370	COG0596	Alpha beta hydrolase
L2Z39_RS08375	COG0616	signal peptide processing
L2Z39_RS08375	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Z39_RS08385	COG0658	competence protein
L2Z39_RS08385	COG2333	competence protein COMEC
L2Z39_RS08390	COG1136	(ABC) transporter
L2Z39_RS08395	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Z39_RS08430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z39_RS08450	COG0463	Glycosyl transferase, family 2
L2Z39_RS08480	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z39_RS08485	COG1280	lysine exporter protein (LysE YggA)
L2Z39_RS08495	COG0019	diaminopimelate decarboxylase activity
L2Z39_RS08505	COG1113	amino acid transport
L2Z39_RS08520	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Z39_RS08530	COG3339	Conserved Protein
L2Z39_RS08535	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2Z39_RS08540	COG0243	molybdopterin cofactor binding
L2Z39_RS08545	COG1929	Belongs to the glycerate kinase type-1 family
L2Z39_RS08560	COG0778	Nitroreductase
L2Z39_RS08600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z39_RS08615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z39_RS08635	COG0741	lytic transglycosylase activity
L2Z39_RS08655	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z39_RS08660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z39_RS08680	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z39_RS08685	COG1597	lipid kinase activity
L2Z39_RS08700	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2Z39_RS08705	COG0477	Major facilitator Superfamily
L2Z39_RS08755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Z39_RS08760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z39_RS08785	COG0505	Belongs to the CarA family
L2Z39_RS08805	COG0589	response to stress
L2Z39_RS08820	COG2843	Capsule synthesis protein
L2Z39_RS08855	COG2321	neutral zinc metallopeptidase
L2Z39_RS08860	COG2354	Protein conserved in bacteria
L2Z39_RS08880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z39_RS08905	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Z39_RS08910	COG1053	succinate dehydrogenase
L2Z39_RS08915	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Z39_RS08920	COG2009	succinate dehydrogenase
L2Z39_RS08955	COG2921	Belongs to the UPF0250 family
L2Z39_RS08960	COG0321	lipoyl(octanoyl) transferase activity
L2Z39_RS08975	COG0531	amino acid
L2Z39_RS08985	COG1733	regulation of RNA biosynthetic process
L2Z39_RS08990	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Z39_RS08995	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Z39_RS08995	COG1648	precorrin-2 dehydrogenase activity
L2Z39_RS09010	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Z39_RS09040	COG0671	phosphoesterase, PA-phosphatase related
L2Z39_RS09045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z39_RS09055	COG1538	Outer membrane efflux protein
L2Z39_RS09060	COG0393	Putative heavy-metal-binding
L2Z39_RS09065	COG0393	Putative heavy-metal-binding
L2Z39_RS09075	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z39_RS09085	COG0525	valine-tRNA ligase activity
L2Z39_RS09105	COG0583	DNA-binding transcription factor activity
L2Z39_RS09110	COG0004	ammonium transporteR
L2Z39_RS09120	COG0642	Histidine kinase
L2Z39_RS09125	COG0745	RESPONSE REGULATOR receiver
L2Z39_RS09130	COG2194	sulfuric ester hydrolase activity
L2Z39_RS09150	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z39_RS09165	COG2315	Protein conserved in bacteria
L2Z39_RS09170	COG0142	geranyltranstransferase activity
L2Z39_RS09175	COG2828	Protein conserved in bacteria
L2Z39_RS09180	COG1113	amino acid transport
L2Z39_RS09200	COG2207	Transcriptional regulator
L2Z39_RS09235	COG0560	Phosphoserine phosphatase
L2Z39_RS09245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z39_RS09255	COG1530	ribonuclease E activity
L2Z39_RS09260	COG0424	maF-like protein
L2Z39_RS09265	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2Z39_RS09270	COG1792	Involved in formation and maintenance of cell shape
L2Z39_RS09275	COG1077	Cell shape determining protein MreB Mrl
L2Z39_RS09280	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z39_RS09290	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z39_RS09320	COG3590	peptidase
L2Z39_RS09325	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2Z39_RS09330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z39_RS09335	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z39_RS09340	COG1115	amino acid carrier protein
L2Z39_RS09360	COG2814	Major facilitator Superfamily
L2Z39_RS09365	COG1289	transmembrane transporter activity
L2Z39_RS09375	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Z39_RS09415	COG1376	ErfK ybiS ycfS ynhG family protein
L2Z39_RS09420	COG2832	Protein of unknown function (DUF454)
L2Z39_RS09430	COG5510	response to toxic substance
L2Z39_RS09450	COG0840	transmembrane signaling receptor activity
L2Z39_RS09495	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Z39_RS09500	COG3189	MarR family transcriptional regulator
L2Z39_RS09510	COG0354	folic acid binding
L2Z39_RS09515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z39_RS09525	COG0679	Auxin Efflux Carrier
L2Z39_RS09530	COG1902	pentaerythritol trinitrate reductase activity
L2Z39_RS09540	COG2094	Belongs to the DNA glycosylase MPG family
L2Z39_RS09565	COG1217	gtp-binding protein TYPA
L2Z39_RS09570	COG2233	PERMEase
L2Z39_RS09580	COG0833	amino acid
L2Z39_RS09585	COG1690	Belongs to the RtcB family
L2Z39_RS09595	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L2Z39_RS09595	COG2885	chlorophyll binding
L2Z39_RS09605	COG0183	Belongs to the thiolase family
L2Z39_RS09625	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z39_RS09645	COG2207	Transcriptional regulator
L2Z39_RS09650	COG0183	Belongs to the thiolase family
L2Z39_RS09680	COG1272	protein, Hemolysin III
L2Z39_RS09685	COG0477	Major facilitator Superfamily
L2Z39_RS09700	COG0450	alkyl hydroperoxide reductase
L2Z39_RS09720	COG0285	dihydrofolate synthase activity
L2Z39_RS09770	COG2096	Adenosyltransferase
L2Z39_RS09790	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Z39_RS09795	COG0745	RESPONSE REGULATOR receiver
L2Z39_RS09800	COG2205	protein histidine kinase activity
L2Z39_RS09810	COG1960	acyl-CoA dehydrogenase activity
L2Z39_RS09815	COG1960	acyl-CoA dehydrogenase activity
L2Z39_RS09885	COG0438	transferase activity, transferring glycosyl groups
L2Z39_RS09895	COG0438	transferase activity, transferring glycosyl groups
L2Z39_RS09900	COG0726	polysaccharide deacetylase
L2Z39_RS09915	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Z39_RS09920	COG2205	protein histidine kinase activity
L2Z39_RS09950	COG1862	Preprotein translocase
L2Z39_RS09960	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2Z39_RS09965	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Z39_RS09975	COG3781	membrane
L2Z39_RS09980	COG0613	PHP domain protein
L2Z39_RS09990	COG2350	Protein conserved in bacteria
L2Z39_RS10020	COG1607	acyl-coa hydrolase
L2Z39_RS10085	COG2199	diguanylate cyclase activity
L2Z39_RS10095	COG1408	metallophosphoesterase
L2Z39_RS10100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z39_RS10110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Z39_RS10130	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z39_RS10135	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Z39_RS10150	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Z39_RS10160	COG2969	positive regulation of protein catabolic process
L2Z39_RS10180	COG1960	acyl-CoA dehydrogenase activity
L2Z39_RS10185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z39_RS10200	COG1309	transcriptional regulator
L2Z39_RS10205	COG1960	acyl-CoA dehydrogenase activity
L2Z39_RS10250	COG1183	phosphatidylcholine synthase activity
L2Z39_RS10255	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Z39_RS10285	COG1196	nuclear chromosome segregation
L2Z39_RS10285	COG0739	heme binding
L2Z39_RS10285	COG0741	lytic transglycosylase activity
L2Z39_RS10295	COG1702	phosphate starvation-inducible protein PhoH
L2Z39_RS10330	COG1295	ribonuclease BN
L2Z39_RS10335	COG0697	spore germination
L2Z39_RS10340	COG2169	Transcriptional regulator
L2Z39_RS10345	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Z39_RS10390	COG0557	exoribonuclease II activity
L2Z39_RS10395	COG0339	signal peptide processing
L2Z39_RS10400	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2Z39_RS10435	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Z39_RS10440	COG1960	acyl-CoA dehydrogenase activity
L2Z39_RS10595	COG0626	cystathionine gamma-synthase activity
L2Z39_RS10600	COG0433	COG0433 Predicted ATPase
L2Z39_RS10610	COG1017	nitric oxide dioxygenase activity
L2Z39_RS10610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z39_RS10615	COG1959	2 iron, 2 sulfur cluster binding
L2Z39_RS10630	COG1301	dicarboxylic acid transport
L2Z39_RS10635	COG1946	Acyl-CoA thioesterase
L2Z39_RS10655	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2Z39_RS10660	COG1040	competence protein
L2Z39_RS10665	COG0494	nUDIX hydrolase
L2Z39_RS10675	COG0598	Magnesium transport protein CorA
L2Z39_RS10685	COG2854	intermembrane phospholipid transfer
L2Z39_RS10695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Z39_RS10700	COG1127	ABC transporter
L2Z39_RS10710	COG0513	Belongs to the DEAD box helicase family
L2Z39_RS10730	COG0408	coproporphyrinogen oxidase activity
L2Z39_RS10745	COG1960	acyl-CoA dehydrogenase activity
L2Z39_RS10755	COG1983	PspC domain protein
L2Z39_RS10760	COG0517	IMP dehydrogenase activity
L2Z39_RS10795	COG1106	Psort location Cytoplasmic, score
L2Z39_RS10820	COG0583	DNA-binding transcription factor activity
L2Z39_RS10875	COG1012	belongs to the aldehyde dehydrogenase family
L2Z39_RS10885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z39_RS10890	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z39_RS10895	COG0833	amino acid
L2Z39_RS10935	COG1192	Involved in chromosome partitioning
L2Z39_RS10940	COG0628	permease
L2Z39_RS10950	COG1289	transmembrane transporter activity
L2Z39_RS10965	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z39_RS10970	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2Z39_RS10980	COG0277	FAD linked oxidase domain protein
L2Z39_RS10985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Z39_RS11010	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Z39_RS11015	COG5380	lipid catabolic process
L2Z39_RS11040	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Z39_RS11090	COG0194	GDP metabolic process
L2Z39_RS11105	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z39_RS11125	COG3307	-O-antigen
L2Z39_RS11145	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2Z39_RS11150	COG1704	LemA family
L2Z39_RS11160	COG0493	'glutamate synthase
L2Z39_RS11165	COG0070	glutamate synthase
L2Z39_RS11165	COG0069	glutamate synthase activity
L2Z39_RS11165	COG0067	glutamate synthase
L2Z39_RS11215	COG2226	methyltransferase
L2Z39_RS11230	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Z39_RS11235	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Z39_RS11280	COG0833	amino acid
L2Z39_RS11375	COG0488	(ABC) transporter
L2Z39_RS11380	COG2873	o-acetylhomoserine
L2Z39_RS11385	COG4221	oxidoreductase activity
L2Z39_RS11390	COG0659	secondary active sulfate transmembrane transporter activity
L2Z39_RS11415	COG0427	acetyl-CoA hydrolase
L2Z39_RS11440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Z39_RS11480	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Z39_RS11560	COG1733	regulation of RNA biosynthetic process
L2Z39_RS11590	COG0667	Aldo Keto reductase
L2Z39_RS11610	COG0583	DNA-binding transcription factor activity
L2Z39_RS11615	COG2814	Major facilitator Superfamily
L2Z39_RS11645	COG1335	isochorismatase
L2Z39_RS11655	COG1012	belongs to the aldehyde dehydrogenase family
L2Z39_RS11660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z39_RS11670	COG1113	amino acid transport
L2Z39_RS11680	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z39_RS11695	COG2814	Major facilitator Superfamily
L2Z39_RS11705	COG0352	thiamine-phosphate diphosphorylase activity
L2Z39_RS11705	COG0351	phosphomethylpyrimidine kinase
L2Z39_RS11705	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z39_RS11725	COG1309	transcriptional regulator
L2Z39_RS11730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2Z39_RS11755	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z39_RS11765	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z39_RS11770	COG3162	membrane
L2Z39_RS11775	COG0784	Response regulator, receiver
L2Z39_RS11775	COG2198	Histidine kinase
L2Z39_RS11775	COG2205	protein histidine kinase activity
L2Z39_RS11800	COG1522	sequence-specific DNA binding
L2Z39_RS11810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z39_RS11820	COG0668	transmembrane transport
L2Z39_RS11825	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z39_RS11830	COG1519	Transferase
L2Z39_RS11835	COG1902	pentaerythritol trinitrate reductase activity
L2Z39_RS11855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2Z39_RS11880	COG0426	domain, Protein
L2Z39_RS11880	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z39_RS11890	COG2119	membrane
L2Z39_RS11900	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z39_RS11910	COG4942	peptidase
L2Z39_RS11925	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Z39_RS11935	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Z39_RS11955	COG0189	ligase activity
L2Z39_RS11980	COG0708	Exodeoxyribonuclease III
L2Z39_RS11985	COG1393	Belongs to the ArsC family
L2Z39_RS12000	COG3706	GGDEF domain
L2Z39_RS12035	COG2351	hydroxyisourate hydrolase activity
L2Z39_RS12040	COG2233	PERMEase
L2Z39_RS12050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z39_RS12060	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2Z39_RS12065	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z39_RS12075	COG3150	esterase
L2Z39_RS12130	COG2918	glutathione biosynthetic process
L2Z39_RS12145	COG2733	membrane
L2Z39_RS12150	COG0436	Aminotransferase
L2Z39_RS12155	COG0534	Mate efflux family protein
L2Z39_RS12240	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2Z39_RS12245	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Z39_RS12255	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2Z39_RS12305	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z39_RS12330	COG0010	Belongs to the arginase family
L2Z39_RS12360	COG2188	Transcriptional regulator
L2Z39_RS12370	COG0523	cobalamin synthesis protein
L2Z39_RS12380	COG1113	amino acid transport
L2Z39_RS12390	COG0625	glutathione transferase activity
L2Z39_RS12410	COG1683	Conserved Protein
L2Z39_RS12415	COG0534	Mate efflux family protein
L2Z39_RS12420	COG0385	Bile acid
L2Z39_RS12425	COG1335	isochorismatase
L2Z39_RS12430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z39_RS12450	COG2116	formate transmembrane transporter activity
L2Z39_RS12455	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Z39_RS12460	COG2133	pyrroloquinoline quinone binding
L2Z39_RS12465	COG2983	Belongs to the UPF0260 family
L2Z39_RS12485	COG1194	a g-specific adenine glycosylase
L2Z39_RS12500	COG2818	Glycosylase
L2Z39_RS12505	COG1064	alcohol dehydrogenase
L2Z39_RS12510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z39_RS12525	COG0583	DNA-binding transcription factor activity
L2Z39_RS12535	COG2814	Major facilitator Superfamily
L2Z39_RS12570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z39_RS12590	COG2233	PERMEase
L2Z39_RS12595	COG0583	DNA-binding transcription factor activity
L2Z39_RS12630	COG0733	neurotransmitter:sodium symporter activity
L2Z39_RS12670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2Z39_RS12675	COG0657	acetylesterase activity
L2Z39_RS12695	COG0583	DNA-binding transcription factor activity
L2Z39_RS12725	COG2951	lytic endotransglycosylase activity
L2Z39_RS12730	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Z39_RS12745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Z39_RS12755	COG0671	phosphoesterase, PA-phosphatase related
L2Z39_RS12760	COG0861	Integral membrane protein TerC family
L2Z39_RS12770	COG0754	glutathionylspermidine amidase activity
L2Z39_RS12780	COG0402	S-adenosylhomocysteine deaminase activity
L2Z39_RS12795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z39_RS12800	COG1230	cation diffusion facilitator family transporter
L2Z39_RS12815	COG0706	membrane insertase activity
L2Z39_RS12840	COG0592	DNA-directed DNA polymerase activity
L2Z39_RS12850	COG0187	DNA topoisomerase II activity
L2Z39_RS12860	COG0586	Pfam SNARE associated Golgi protein
L2Z39_RS12865	COG0488	(ABC) transporter
L2Z39_RS12890	COG0596	Alpha beta hydrolase
L2Z39_RS12895	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2Z39_RS12900	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2Z39_RS12940	COG1047	Peptidyl-prolyl cis-trans
L2Z39_RS12950	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Z39_RS12955	COG0196	riboflavin kinase activity
L2Z39_RS12965	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2Z39_RS12970	COG1309	transcriptional regulator
L2Z39_RS12975	COG1116	anion transmembrane transporter activity
L2Z39_RS12980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z39_RS12985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z39_RS12990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z39_RS12995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z39_RS13015	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z39_RS13020	COG0546	phosphoglycolate phosphatase activity
L2Z39_RS13075	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2Z39_RS13080	COG0728	peptidoglycan biosynthetic process
L2Z39_RS13105	COG1596	polysaccharide export
L2Z39_RS13110	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z39_RS13120	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
L2Z39_RS13135	COG2030	dehydratase
L2Z39_RS13150	COG0463	Glycosyl transferase, family 2
L2Z39_RS13150	COG1216	Glycosyl transferase, family 2
L2Z39_RS13155	COG0438	transferase activity, transferring glycosyl groups
L2Z39_RS13170	COG1216	Glycosyl transferase, family 2
L2Z39_RS13175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L2Z39_RS13180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Z39_RS13195	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z39_RS13205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z39_RS13215	COG2186	Transcriptional regulator
L2Z39_RS13225	COG0277	FAD linked oxidase domain protein
L2Z39_RS13230	COG1448	Aminotransferase
L2Z39_RS13240	COG1802	Transcriptional regulator
L2Z39_RS13255	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2Z39_RS13295	COG0564	pseudouridine synthase activity
L2Z39_RS13335	COG0251	oxidation-reduction process
L2Z39_RS13340	COG1113	amino acid transport
L2Z39_RS13345	COG1113	amino acid transport
L2Z39_RS13365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z39_RS13370	COG1960	acyl-CoA dehydrogenase activity
L2Z39_RS13375	COG1024	Enoyl-CoA hydratase
L2Z39_RS13380	COG1024	Enoyl-CoA hydratase
L2Z39_RS13385	COG0477	Major facilitator Superfamily
L2Z39_RS13390	COG3916	Acyl-homoserine-lactone synthase
L2Z39_RS13400	COG2197	response regulator
L2Z39_RS13430	COG0271	Belongs to the BolA IbaG family
L2Z39_RS13440	COG1192	Involved in chromosome partitioning
L2Z39_RS13455	COG0586	Pfam SNARE associated Golgi protein
L2Z39_RS13460	COG2259	Doxx family
L2Z39_RS13465	COG4399	Belongs to the UPF0754 family
L2Z39_RS13470	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z39_RS13470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z39_RS13520	COG0281	malic enzyme
L2Z39_RS13525	COG2837	iron assimilation
L2Z39_RS13530	COG1280	lysine exporter protein (LysE YggA)
L2Z39_RS13535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Z39_RS13540	COG1121	(ABC) transporter
L2Z39_RS13605	COG0386	Belongs to the glutathione peroxidase family
L2Z39_RS13620	COG1309	transcriptional regulator
L2Z39_RS13625	COG0697	spore germination
L2Z39_RS13635	COG0758	DNA mediated transformation
L2Z39_RS13705	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2Z39_RS13715	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2Z39_RS13755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z39_RS13775	COG1253	flavin adenine dinucleotide binding
L2Z39_RS13785	COG2860	membrane
L2Z39_RS13790	COG0477	Major facilitator Superfamily
L2Z39_RS13800	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z39_RS13815	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Z39_RS13835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z39_RS13845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z39_RS13880	COG0589	response to stress
L2Z39_RS13885	COG0659	secondary active sulfate transmembrane transporter activity
L2Z39_RS13895	COG1002	Type II restriction enzyme, methylase subunits
L2Z39_RS13900	COG1061	Type III restriction enzyme res subunit
L2Z39_RS13975	COG0347	Belongs to the P(II) protein family
L2Z39_RS13980	COG0004	ammonium transporteR
L2Z39_RS13990	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z39_RS13990	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z39_RS14030	COG0795	lipopolysaccharide-transporting ATPase activity
L2Z39_RS14035	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Z39_RS14040	COG0793	Belongs to the peptidase S41A family
L2Z39_RS14055	COG2197	response regulator
L2Z39_RS14065	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2Z39_RS14075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z39_RS14080	COG4974	Belongs to the 'phage' integrase family
L2Z39_RS14105	COG0772	Belongs to the SEDS family
L2Z39_RS14110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z39_RS14115	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Z39_RS14120	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z39_RS14145	COG0697	spore germination
L2Z39_RS14150	COG1538	Outer membrane efflux protein
L2Z39_RS14170	COG3275	phosphorelay sensor kinase activity
L2Z39_RS14180	COG0181	hydroxymethylbilane synthase activity
L2Z39_RS14225	COG1716	ATPase activity
L2Z39_RS14230	COG0546	phosphoglycolate phosphatase activity
L2Z39_RS14325	COG0596	Alpha beta hydrolase
L2Z39_RS14330	COG2056	Na+-H+ antiporter family
L2Z39_RS14345	COG0326	Molecular chaperone. Has ATPase activity
L2Z39_RS14360	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2Z39_RS14425	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2Z39_RS14430	COG2169	Transcriptional regulator
L2Z39_RS14430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z39_RS14460	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Z39_RS14470	COG0497	DNA recombination
L2Z39_RS14485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z39_RS14495	COG0237	dephospho-CoA kinase activity
L2Z39_RS14500	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L2Z39_RS14550	COG0195	Participates in both transcription termination and antitermination
L2Z39_RS14565	COG1320	monovalent cation:proton antiporter activity
L2Z39_RS14570	COG2212	antiporter activity
L2Z39_RS14575	COG1863	multisubunit Na H antiporter MnhE subunit
L2Z39_RS14580	COG0651	ATP synthesis coupled electron transport
L2Z39_RS14585	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Z39_RS14590	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z39_RS14590	COG2111	Na H antiporter
L2Z39_RS14605	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Z39_RS14610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z39_RS14625	COG2226	methyltransferase
L2Z39_RS14645	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Z39_RS14650	COG1074	ATP-dependent DNA helicase activity
L2Z39_RS14655	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z39_RS14660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z39_RS14675	COG0598	Magnesium transport protein CorA
L2Z39_RS14680	COG0789	Transcriptional regulator
L2Z39_RS14685	COG0484	heat shock protein binding
L2Z39_RS14695	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L2Z39_RS14700	COG0475	glutathione-regulated potassium exporter activity
L2Z39_RS14700	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z39_RS14705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Z39_RS14725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z39_RS14735	COG4535	Mg2 and Co2 transporter CorC
L2Z39_RS14740	COG0425	Belongs to the sulfur carrier protein TusA family
L2Z39_RS14745	COG0644	oxidoreductase
L2Z39_RS14745	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2Z39_RS14755	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z39_RS14770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z39_RS14775	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2Z39_RS14815	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Z39_RS14830	COG0534	Mate efflux family protein
L2Z39_RS14840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z39_RS14845	COG4221	oxidoreductase activity
L2Z39_RS14850	COG0583	DNA-binding transcription factor activity
L2Z39_RS14865	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z39_RS14870	COG1530	ribonuclease E activity
L2Z39_RS14880	COG0546	phosphoglycolate phosphatase activity
L2Z39_RS14885	COG2378	regulation of single-species biofilm formation
L2Z39_RS14890	COG0625	glutathione transferase activity
L2Z39_RS14900	COG0583	DNA-binding transcription factor activity
L2Z39_RS14965	COG0473	3-isopropylmalate dehydrogenase activity
L2Z39_RS15020	COG1301	dicarboxylic acid transport
L2Z39_RS15030	COG1560	Kdo2-lipid A biosynthetic process
L2Z39_RS15035	COG1280	lysine exporter protein (LysE YggA)
L2Z39_RS15040	COG0488	(ABC) transporter
L2Z39_RS15045	COG2900	Belongs to the SlyX family
L2Z39_RS15055	COG1733	regulation of RNA biosynthetic process
L2Z39_RS15080	COG0210	DNA helicase
L2Z39_RS15085	COG0724	RNA recognition motif
L2Z39_RS15105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z39_RS15105	COG4651	solute:proton antiporter activity
L2Z39_RS15130	COG0788	formyltetrahydrofolate deformylase activity
L2Z39_RS15230	COG2813	Specifically methylates the guanine in position
L2Z39_RS15230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z39_RS15240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z39_RS15270	COG0740	serine-type endopeptidase activity
L2Z39_RS15290	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z39_RS15290	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z39_RS15295	COG0280	phosphate acetyltransferase
L2Z39_RS15295	COG0857	belongs to the CobB CobQ family
L2Z39_RS15300	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Z39_RS15310	COG0800	Aldolase
L2Z39_RS15320	COG3265	gluconokinase activity
L2Z39_RS15325	COG1012	belongs to the aldehyde dehydrogenase family
L2Z39_RS15335	COG2267	carboxylic ester hydrolase activity
L2Z39_RS15350	COG0793	Belongs to the peptidase S41A family
L2Z39_RS15385	COG1426	Protein conserved in bacteria
L2Z39_RS15430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z39_RS15440	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z39_RS15455	COG2986	histidine ammonia-lyase
L2Z39_RS15495	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z39_RS15500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L2Z39_RS15520	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2Z39_RS15530	COG1162	GTPase activity
L2Z39_RS15535	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Z39_RS15550	COG1538	Outer membrane efflux protein
L2Z39_RS15555	COG0577	efflux transmembrane transporter activity
L2Z39_RS15555	COG1136	(ABC) transporter
L2Z39_RS15560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z39_RS15585	COG0028	Belongs to the TPP enzyme family
L2Z39_RS15590	COG0440	acetolactate synthase activity
L2Z39_RS15625	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Z39_RS15640	COG0084	hydrolase, TatD family'
L2Z39_RS15655	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Z39_RS15665	COG0583	DNA-binding transcription factor activity
L2Z39_RS15675	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z39_RS15680	COG2814	Major facilitator Superfamily
L2Z39_RS15690	COG0697	spore germination
L2Z39_RS15720	COG3622	Belongs to the hyi family
L2Z39_RS15725	COG2084	Dehydrogenase
L2Z39_RS15730	COG1024	Enoyl-CoA hydratase
L2Z39_RS15735	COG0784	Response regulator, receiver
L2Z39_RS15735	COG2205	protein histidine kinase activity
L2Z39_RS15735	COG5002	protein histidine kinase activity
L2Z39_RS15755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z39_RS15765	COG3956	TIGRFAM MazG family protein
L2Z39_RS15770	COG1555	photosystem II stabilization
L2Z39_RS15775	COG0617	tRNA 3'-terminal CCA addition
L2Z39_RS15780	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Z39_RS15800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z39_RS15805	COG3028	Belongs to the UPF0307 family
L2Z39_RS15810	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z39_RS15825	COG0625	glutathione transferase activity
L2Z39_RS15830	COG1238	metal cluster binding
L2Z39_RS15875	COG0072	phenylalanine-tRNA ligase activity
L2Z39_RS15905	COG0248	Ppx GppA phosphatase
L2Z39_RS15915	COG0037	tRNA processing
L2Z39_RS15955	COG1764	response to oxidative stress
L2Z39_RS15960	COG1846	Transcriptional regulator
L2Z39_RS15970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z39_RS16030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2Z39_RS16035	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Z39_RS16040	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Z39_RS16050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L2Z39_RS16100	COG1214	PFAM Peptidase M22, glycoprotease
L2Z39_RS16125	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z39_RS16130	COG0561	phosphatase activity
L2Z39_RS16140	COG2132	Multicopper oxidase
L2Z39_RS16145	COG3667	copper resistance
L2Z39_RS16160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z39_RS16165	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Z39_RS16170	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Z39_RS16200	COG1063	alcohol dehydrogenase
L2Z39_RS16205	COG0583	DNA-binding transcription factor activity
L2Z39_RS16210	COG1960	acyl-CoA dehydrogenase activity
L2Z39_RS16215	COG2814	Major facilitator Superfamily
L2Z39_RS16220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z39_RS16230	COG1053	succinate dehydrogenase
L2Z39_RS16235	COG0583	DNA-binding transcription factor activity
L2Z39_RS16250	COG0583	DNA-binding transcription factor activity
L2Z39_RS16280	COG0583	DNA-binding transcription factor activity
L2Z39_RS16295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z39_RS16320	COG0384	phenazine biosynthesis protein PhzF
L2Z39_RS16345	COG4993	Dehydrogenase
L2Z39_RS16420	COG2205	protein histidine kinase activity
L2Z39_RS16430	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Z39_RS16450	COG0745	RESPONSE REGULATOR receiver
L2Z39_RS16490	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Z39_RS16520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z39_RS16525	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Z39_RS16550	COG0583	DNA-binding transcription factor activity
L2Z39_RS16570	COG0668	transmembrane transport
L2Z39_RS16580	COG2081	HI0933 family
L2Z39_RS16590	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z39_RS16620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z39_RS16620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z39_RS16630	COG0489	protein tyrosine kinase activity
L2Z39_RS16680	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z39_RS16690	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Z39_RS16705	COG0730	response to heat
L2Z39_RS16715	COG1196	nuclear chromosome segregation
L2Z39_RS16735	COG2223	nitrite transmembrane transporter activity
L2Z39_RS16740	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2Z39_RS16745	COG1877	trehalose-phosphatase activity
L2Z39_RS16750	COG0596	Alpha beta hydrolase
L2Z39_RS16750	COG2226	methyltransferase
L2Z39_RS16750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z39_RS16765	COG4106	trans-aconitate 2-methyltransferase activity
L2Z39_RS16780	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Z39_RS16785	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2Z39_RS16790	COG0009	L-threonylcarbamoyladenylate synthase
L2Z39_RS16795	COG3101	peptidyl-lysine hydroxylation
L2Z39_RS16800	COG1399	metal-binding, possibly nucleic acid-binding protein
L2Z39_RS16825	COG1652	LysM domain
L2Z39_RS16830	COG0352	thiamine-phosphate diphosphorylase activity
L2Z39_RS16830	COG0351	phosphomethylpyrimidine kinase
L2Z39_RS16830	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z39_RS16840	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2Z39_RS16870	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z39_RS16900	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Z39_RS16915	COG0358	DNA primase activity
L2Z39_RS16925	COG0564	pseudouridine synthase activity
L2Z39_RS16950	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z39_RS16970	COG0583	DNA-binding transcription factor activity
L2Z39_RS16975	COG0473	3-isopropylmalate dehydrogenase activity
L2Z39_RS16985	COG0657	acetylesterase activity
L2Z39_RS16995	COG1012	belongs to the aldehyde dehydrogenase family
L2Z39_RS17015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z39_RS17015	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Z39_RS17030	COG1981	membrane
L2Z39_RS17135	COG0305	Participates in initiation and elongation during chromosome replication
L2Z39_RS17225	COG4695	Portal protein
L2Z39_RS17265	COG3646	Phage regulatory protein
L2Z39_RS17290	COG1196	nuclear chromosome segregation
L2Z39_RS17290	COG0741	lytic transglycosylase activity
L2Z39_RS17290	COG0739	heme binding
L2Z39_RS17370	COG0456	acetyltransferase
L2Z39_RS17380	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Z39_RS17385	COG0492	ferredoxin-NADP+ reductase activity
L2Z39_RS17390	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Z39_RS17390	COG1674	ftsk spoiiie
L2Z39_RS17395	COG1280	lysine exporter protein (LysE YggA)
L2Z39_RS17420	COG2894	cell division
L2Z39_RS17435	COG0204	Acyl-transferase
L2Z39_RS17440	COG2885	chlorophyll binding
L2Z39_RS17445	COG0210	DNA helicase
L2Z39_RS17455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z39_RS17470	COG0121	glutamine amidotransferase
L2Z39_RS17490	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z39_RS17495	COG0735	belongs to the Fur family
L2Z39_RS17520	COG0420	3'-5' exonuclease activity
L2Z39_RS17540	COG1090	epimerase
L2Z39_RS17555	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z39_RS17565	COG2814	Major facilitator Superfamily
L2Z39_RS17570	COG0405	Gamma-glutamyltransferase
L2Z39_RS17650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z39_RS17740	COG1484	DNA-dependent DNA replication
L2Z39_RS17785	COG3755	Protein conserved in bacteria
L2Z39_RS17945	COG2026	Addiction module toxin, RelE StbE family
L2Z39_RS18100	COG0582	viral genome integration into host DNA
L2Z39_RS18155	COG0629	single-stranded DNA binding
L2Z39_RS18195	COG0084	hydrolase, TatD family'
L2Z39_RS18215	COG0477	Major facilitator Superfamily
L2Z39_RS18220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z39_RS18230	COG1595	DNA-templated transcription, initiation
L2Z39_RS18285	COG0531	amino acid
L2Z39_RS18290	COG2040	homocysteine
L2Z39_RS18335	COG1309	transcriptional regulator
L2Z39_RS18340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z39_RS18345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z39_RS18355	COG1607	acyl-coa hydrolase
L2Z39_RS18365	COG0523	cobalamin synthesis protein
L2Z39_RS18375	COG4681	YaeQ
L2Z39_RS18385	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z39_RS18385	COG0726	polysaccharide deacetylase
L2Z39_RS18390	COG1215	transferase activity, transferring glycosyl groups
L2Z39_RS18400	COG1024	Enoyl-CoA hydratase
L2Z39_RS18405	COG1484	DNA-dependent DNA replication
L2Z39_RS18410	COG2390	Transcriptional regulator
L2Z39_RS18410	COG4584	PFAM Integrase catalytic
L2Z39_RS18435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z39_RS18455	COG1414	Transcriptional regulator
L2Z39_RS18475	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z39_RS18485	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z39_RS18490	COG2271	Major facilitator Superfamily
L2Z39_RS18500	COG2267	carboxylic ester hydrolase activity
L2Z39_RS18505	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z39_RS18520	COG0028	Belongs to the TPP enzyme family
L2Z39_RS18530	COG0477	Major facilitator Superfamily
L2Z39_RS18535	COG0242	peptide deformylase activity
L2Z39_RS18540	COG2066	Belongs to the glutaminase family
L2Z39_RS18545	COG2207	Transcriptional regulator
L2Z39_RS18550	COG2223	nitrite transmembrane transporter activity
L2Z39_RS18565	COG0583	DNA-binding transcription factor activity
L2Z39_RS18570	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z39_RS18575	COG2271	Major facilitator Superfamily
L2Z39_RS18580	COG3959	Transketolase, thiamine diphosphate binding domain
L2Z39_RS18585	COG3958	Transketolase
L2Z39_RS18595	COG0306	phosphate transporter
L2Z39_RS18615	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z39_RS18660	COG4181	ATPase activity
L2Z39_RS18665	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Z39_RS18690	COG0583	DNA-binding transcription factor activity
L2Z39_RS18700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z39_RS18705	COG1773	rubredoxin
L2Z39_RS18755	COG2851	Citrate transporter
L2Z39_RS18760	COG1253	flavin adenine dinucleotide binding
L2Z39_RS18800	COG0804	urea catabolic process
L2Z39_RS18810	COG0830	nickel cation binding
L2Z39_RS18825	COG0742	ribosomal rna small subunit methyltransferase
L2Z39_RS18830	COG0768	penicillin binding
L2Z39_RS18855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Z39_RS18860	COG2878	Part of a membrane complex involved in electron transport
L2Z39_RS18865	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z39_RS18875	COG3384	dioxygenase
L2Z39_RS18900	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2Z39_RS19225	COG0739	heme binding
L2Z39_RS19280	COG2194	sulfuric ester hydrolase activity
L2Z39_RS19335	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Z39_RS19360	COG0305	Participates in initiation and elongation during chromosome replication