locus-tag	class	description
L2Z40_RS00010	COG1183	phosphatidylcholine synthase activity
L2Z40_RS00015	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Z40_RS00045	COG0739	heme binding
L2Z40_RS00045	COG0741	lytic transglycosylase activity
L2Z40_RS00045	COG1196	nuclear chromosome segregation
L2Z40_RS00055	COG1702	phosphate starvation-inducible protein PhoH
L2Z40_RS00090	COG1295	ribonuclease BN
L2Z40_RS00095	COG0697	spore germination
L2Z40_RS00100	COG2169	Transcriptional regulator
L2Z40_RS00105	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Z40_RS00150	COG0557	exoribonuclease II activity
L2Z40_RS00155	COG0339	signal peptide processing
L2Z40_RS00160	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2Z40_RS00190	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Z40_RS00195	COG1960	acyl-CoA dehydrogenase activity
L2Z40_RS00350	COG0626	cystathionine gamma-synthase activity
L2Z40_RS00355	COG0433	COG0433 Predicted ATPase
L2Z40_RS00360	COG1017	nitric oxide dioxygenase activity
L2Z40_RS00360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z40_RS00365	COG1959	2 iron, 2 sulfur cluster binding
L2Z40_RS00380	COG1301	dicarboxylic acid transport
L2Z40_RS00385	COG1946	Acyl-CoA thioesterase
L2Z40_RS00405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2Z40_RS00410	COG1040	competence protein
L2Z40_RS00415	COG0494	nUDIX hydrolase
L2Z40_RS00425	COG0598	Magnesium transport protein CorA
L2Z40_RS00435	COG2854	intermembrane phospholipid transfer
L2Z40_RS00445	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Z40_RS00450	COG1127	ABC transporter
L2Z40_RS00460	COG0513	Belongs to the DEAD box helicase family
L2Z40_RS00480	COG0408	coproporphyrinogen oxidase activity
L2Z40_RS00495	COG1960	acyl-CoA dehydrogenase activity
L2Z40_RS00505	COG1983	PspC domain protein
L2Z40_RS00510	COG0517	IMP dehydrogenase activity
L2Z40_RS00560	COG0583	DNA-binding transcription factor activity
L2Z40_RS00600	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_RS00610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z40_RS00615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z40_RS00620	COG0833	amino acid
L2Z40_RS00650	COG1192	Involved in chromosome partitioning
L2Z40_RS00655	COG0628	permease
L2Z40_RS00665	COG1289	transmembrane transporter activity
L2Z40_RS00680	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z40_RS00685	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2Z40_RS00695	COG0277	FAD linked oxidase domain protein
L2Z40_RS00700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Z40_RS00725	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Z40_RS00730	COG5380	lipid catabolic process
L2Z40_RS00750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Z40_RS00800	COG0194	GDP metabolic process
L2Z40_RS00815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z40_RS00850	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2Z40_RS00855	COG1704	LemA family
L2Z40_RS00865	COG0493	'glutamate synthase
L2Z40_RS00870	COG0070	glutamate synthase
L2Z40_RS00870	COG0069	glutamate synthase activity
L2Z40_RS00870	COG0067	glutamate synthase
L2Z40_RS00920	COG2226	methyltransferase
L2Z40_RS00935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Z40_RS00940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Z40_RS00985	COG0833	amino acid
L2Z40_RS01050	COG0488	(ABC) transporter
L2Z40_RS01055	COG2873	o-acetylhomoserine
L2Z40_RS01060	COG4221	oxidoreductase activity
L2Z40_RS01065	COG0659	secondary active sulfate transmembrane transporter activity
L2Z40_RS01095	COG0427	acetyl-CoA hydrolase
L2Z40_RS01125	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Z40_RS01165	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Z40_RS01225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L2Z40_RS01235	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z40_RS01240	COG1733	regulation of RNA biosynthetic process
L2Z40_RS01255	COG1733	regulation of RNA biosynthetic process
L2Z40_RS01275	COG0667	Aldo Keto reductase
L2Z40_RS01295	COG0583	DNA-binding transcription factor activity
L2Z40_RS01300	COG2814	Major facilitator Superfamily
L2Z40_RS01330	COG1335	isochorismatase
L2Z40_RS01340	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_RS01345	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z40_RS01355	COG1113	amino acid transport
L2Z40_RS01365	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z40_RS01380	COG2814	Major facilitator Superfamily
L2Z40_RS01390	COG0351	phosphomethylpyrimidine kinase
L2Z40_RS01390	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z40_RS01390	COG0352	thiamine-phosphate diphosphorylase activity
L2Z40_RS01410	COG1309	transcriptional regulator
L2Z40_RS01415	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2Z40_RS01430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z40_RS01440	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z40_RS01445	COG3162	membrane
L2Z40_RS01450	COG2198	Histidine kinase
L2Z40_RS01450	COG2205	protein histidine kinase activity
L2Z40_RS01450	COG0784	Response regulator, receiver
L2Z40_RS01475	COG1522	sequence-specific DNA binding
L2Z40_RS01480	COG1335	isochorismatase
L2Z40_RS01485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z40_RS01495	COG0668	transmembrane transport
L2Z40_RS01500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z40_RS01505	COG1519	Transferase
L2Z40_RS01510	COG1902	pentaerythritol trinitrate reductase activity
L2Z40_RS01530	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2Z40_RS01555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z40_RS01555	COG0426	domain, Protein
L2Z40_RS01560	COG4774	siderophore transport
L2Z40_RS01565	COG2119	membrane
L2Z40_RS01575	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z40_RS01585	COG4942	peptidase
L2Z40_RS01600	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Z40_RS01610	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Z40_RS01630	COG0189	ligase activity
L2Z40_RS01650	COG0708	Exodeoxyribonuclease III
L2Z40_RS01655	COG1393	Belongs to the ArsC family
L2Z40_RS01670	COG3706	GGDEF domain
L2Z40_RS01705	COG2351	hydroxyisourate hydrolase activity
L2Z40_RS01710	COG2233	PERMEase
L2Z40_RS01720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z40_RS01730	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2Z40_RS01740	COG3150	esterase
L2Z40_RS01770	COG3409	Peptidoglycan-binding domain 1 protein
L2Z40_RS01770	COG1388	LysM domain
L2Z40_RS01770	COG5632	N-Acetylmuramoyl-L-alanine amidase
L2Z40_RS01785	COG2918	glutathione biosynthetic process
L2Z40_RS01800	COG2733	membrane
L2Z40_RS01805	COG0436	Aminotransferase
L2Z40_RS01810	COG0534	Mate efflux family protein
L2Z40_RS01895	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2Z40_RS01900	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Z40_RS01910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2Z40_RS01945	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z40_RS01960	COG0010	Belongs to the arginase family
L2Z40_RS01990	COG2188	Transcriptional regulator
L2Z40_RS02000	COG0523	cobalamin synthesis protein
L2Z40_RS02010	COG1113	amino acid transport
L2Z40_RS02020	COG0625	glutathione transferase activity
L2Z40_RS02040	COG1683	Conserved Protein
L2Z40_RS02045	COG0534	Mate efflux family protein
L2Z40_RS02050	COG0385	Bile acid
L2Z40_RS02055	COG1335	isochorismatase
L2Z40_RS02060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z40_RS02075	COG3676	manually curated
L2Z40_RS02085	COG2116	formate transmembrane transporter activity
L2Z40_RS02090	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Z40_RS02095	COG2133	pyrroloquinoline quinone binding
L2Z40_RS02100	COG2983	Belongs to the UPF0260 family
L2Z40_RS02120	COG1194	a g-specific adenine glycosylase
L2Z40_RS02135	COG2818	Glycosylase
L2Z40_RS02140	COG1064	alcohol dehydrogenase
L2Z40_RS02145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z40_RS02160	COG0583	DNA-binding transcription factor activity
L2Z40_RS02165	COG0656	L-ascorbic acid biosynthetic process
L2Z40_RS02170	COG2814	Major facilitator Superfamily
L2Z40_RS02205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z40_RS02220	COG2233	PERMEase
L2Z40_RS02225	COG0583	DNA-binding transcription factor activity
L2Z40_RS02260	COG0733	neurotransmitter:sodium symporter activity
L2Z40_RS02300	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2Z40_RS02305	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2Z40_RS02335	COG0488	(ABC) transporter
L2Z40_RS02340	COG0586	Pfam SNARE associated Golgi protein
L2Z40_RS02350	COG0187	DNA topoisomerase II activity
L2Z40_RS02360	COG0592	DNA-directed DNA polymerase activity
L2Z40_RS02385	COG0706	membrane insertase activity
L2Z40_RS02400	COG1230	cation diffusion facilitator family transporter
L2Z40_RS02405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z40_RS02420	COG0402	S-adenosylhomocysteine deaminase activity
L2Z40_RS02430	COG0754	glutathionylspermidine amidase activity
L2Z40_RS02440	COG0861	Integral membrane protein TerC family
L2Z40_RS02445	COG0671	phosphoesterase, PA-phosphatase related
L2Z40_RS02455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Z40_RS02470	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Z40_RS02475	COG2951	lytic endotransglycosylase activity
L2Z40_RS02505	COG0583	DNA-binding transcription factor activity
L2Z40_RS02525	COG0657	acetylesterase activity
L2Z40_RS02530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2Z40_RS02570	COG1047	Peptidyl-prolyl cis-trans
L2Z40_RS02580	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Z40_RS02585	COG0196	riboflavin kinase activity
L2Z40_RS02595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2Z40_RS02600	COG1309	transcriptional regulator
L2Z40_RS02610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z40_RS02615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z40_RS02620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z40_RS02625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z40_RS02645	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_RS02650	COG0546	phosphoglycolate phosphatase activity
L2Z40_RS02710	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2Z40_RS02715	COG0728	peptidoglycan biosynthetic process
L2Z40_RS02740	COG1596	polysaccharide export
L2Z40_RS02745	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z40_RS02750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z40_RS02765	COG0438	transferase activity, transferring glycosyl groups
L2Z40_RS02775	COG0438	transferase activity, transferring glycosyl groups
L2Z40_RS02780	COG0438	transferase activity, transferring glycosyl groups
L2Z40_RS02790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L2Z40_RS02795	COG0110	maltose O-acetyltransferase activity
L2Z40_RS02805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z40_RS02820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Z40_RS02825	COG3676	manually curated
L2Z40_RS02840	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z40_RS02845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z40_RS02855	COG2186	Transcriptional regulator
L2Z40_RS02865	COG0277	FAD linked oxidase domain protein
L2Z40_RS02870	COG1448	Aminotransferase
L2Z40_RS02875	COG1802	Transcriptional regulator
L2Z40_RS02890	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2Z40_RS02915	COG3328	transposase activity
L2Z40_RS02930	COG0564	pseudouridine synthase activity
L2Z40_RS02970	COG0251	oxidation-reduction process
L2Z40_RS02975	COG1113	amino acid transport
L2Z40_RS02980	COG1113	amino acid transport
L2Z40_RS03000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z40_RS03005	COG1960	acyl-CoA dehydrogenase activity
L2Z40_RS03010	COG1024	Enoyl-CoA hydratase
L2Z40_RS03015	COG1024	Enoyl-CoA hydratase
L2Z40_RS03020	COG0477	Major facilitator Superfamily
L2Z40_RS03025	COG3916	Acyl-homoserine-lactone synthase
L2Z40_RS03035	COG2197	response regulator
L2Z40_RS03045	COG1960	acyl-CoA dehydrogenase activity
L2Z40_RS03050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z40_RS03050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Z40_RS03050	COG3321	synthase
L2Z40_RS03050	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
L2Z40_RS03070	COG2267	carboxylic ester hydrolase activity
L2Z40_RS03090	COG0271	Belongs to the BolA IbaG family
L2Z40_RS03100	COG1192	Involved in chromosome partitioning
L2Z40_RS03115	COG0586	Pfam SNARE associated Golgi protein
L2Z40_RS03120	COG2259	Doxx family
L2Z40_RS03125	COG4399	Belongs to the UPF0754 family
L2Z40_RS03130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z40_RS03130	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z40_RS03175	COG0281	malic enzyme
L2Z40_RS03180	COG2837	iron assimilation
L2Z40_RS03185	COG1280	lysine exporter protein (LysE YggA)
L2Z40_RS03190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Z40_RS03195	COG1121	(ABC) transporter
L2Z40_RS03260	COG0386	Belongs to the glutathione peroxidase family
L2Z40_RS03275	COG1309	transcriptional regulator
L2Z40_RS03280	COG0697	spore germination
L2Z40_RS03290	COG0758	DNA mediated transformation
L2Z40_RS03360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2Z40_RS03370	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2Z40_RS03410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z40_RS03420	COG0477	Major facilitator Superfamily
L2Z40_RS03430	COG1253	flavin adenine dinucleotide binding
L2Z40_RS03435	COG3012	SEC-C Motif Domain Protein
L2Z40_RS03440	COG2860	membrane
L2Z40_RS03445	COG0477	Major facilitator Superfamily
L2Z40_RS03455	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z40_RS03470	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Z40_RS03480	COG3676	manually curated
L2Z40_RS03495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z40_RS03540	COG2072	flavoprotein involved in K transport
L2Z40_RS03545	COG0492	ferredoxin-NADP+ reductase activity
L2Z40_RS03550	COG0431	NADPH-dependent FMN reductase
L2Z40_RS03555	COG0798	PFAM Bile acid sodium symporter
L2Z40_RS03565	COG0640	Transcriptional regulator
L2Z40_RS03580	COG0789	Transcriptional regulator
L2Z40_RS03605	COG0659	secondary active sulfate transmembrane transporter activity
L2Z40_RS03625	COG0347	Belongs to the P(II) protein family
L2Z40_RS03630	COG0004	ammonium transporteR
L2Z40_RS03640	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z40_RS03640	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z40_RS03680	COG0795	lipopolysaccharide-transporting ATPase activity
L2Z40_RS03685	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Z40_RS03690	COG0793	Belongs to the peptidase S41A family
L2Z40_RS03705	COG2197	response regulator
L2Z40_RS03715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2Z40_RS03725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z40_RS03730	COG4974	Belongs to the 'phage' integrase family
L2Z40_RS03755	COG0772	Belongs to the SEDS family
L2Z40_RS03760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z40_RS03765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Z40_RS03770	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z40_RS03795	COG0697	spore germination
L2Z40_RS03800	COG1538	Outer membrane efflux protein
L2Z40_RS03820	COG3275	phosphorelay sensor kinase activity
L2Z40_RS03830	COG0181	hydroxymethylbilane synthase activity
L2Z40_RS03875	COG1716	ATPase activity
L2Z40_RS03880	COG0546	phosphoglycolate phosphatase activity
L2Z40_RS03980	COG2056	Na+-H+ antiporter family
L2Z40_RS03995	COG0326	Molecular chaperone. Has ATPase activity
L2Z40_RS04010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2Z40_RS04070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2Z40_RS04075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z40_RS04075	COG2169	Transcriptional regulator
L2Z40_RS04105	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Z40_RS04115	COG0497	DNA recombination
L2Z40_RS04130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z40_RS04140	COG0237	dephospho-CoA kinase activity
L2Z40_RS04190	COG0195	Participates in both transcription termination and antitermination
L2Z40_RS04205	COG1320	monovalent cation:proton antiporter activity
L2Z40_RS04210	COG2212	antiporter activity
L2Z40_RS04215	COG1863	multisubunit Na H antiporter MnhE subunit
L2Z40_RS04220	COG0651	ATP synthesis coupled electron transport
L2Z40_RS04225	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Z40_RS04230	COG2111	Na H antiporter
L2Z40_RS04230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z40_RS04245	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Z40_RS04250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z40_RS04265	COG2226	methyltransferase
L2Z40_RS04285	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Z40_RS04290	COG1074	ATP-dependent DNA helicase activity
L2Z40_RS04295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z40_RS04300	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z40_RS04315	COG0598	Magnesium transport protein CorA
L2Z40_RS04320	COG0789	Transcriptional regulator
L2Z40_RS04325	COG0484	heat shock protein binding
L2Z40_RS04340	COG0475	glutathione-regulated potassium exporter activity
L2Z40_RS04340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z40_RS04345	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Z40_RS04365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z40_RS04375	COG4535	Mg2 and Co2 transporter CorC
L2Z40_RS04380	COG0425	Belongs to the sulfur carrier protein TusA family
L2Z40_RS04390	COG0644	oxidoreductase
L2Z40_RS04390	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2Z40_RS04400	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z40_RS04415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z40_RS04420	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2Z40_RS04430	COG0493	'glutamate synthase
L2Z40_RS04430	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z40_RS04455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Z40_RS04470	COG0534	Mate efflux family protein
L2Z40_RS04480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z40_RS04485	COG4221	oxidoreductase activity
L2Z40_RS04490	COG0583	DNA-binding transcription factor activity
L2Z40_RS04505	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z40_RS04510	COG1530	ribonuclease E activity
L2Z40_RS04525	COG0546	phosphoglycolate phosphatase activity
L2Z40_RS04530	COG2378	regulation of single-species biofilm formation
L2Z40_RS04535	COG0625	glutathione transferase activity
L2Z40_RS04545	COG0583	DNA-binding transcription factor activity
L2Z40_RS04600	COG0473	3-isopropylmalate dehydrogenase activity
L2Z40_RS04655	COG1301	dicarboxylic acid transport
L2Z40_RS04665	COG1560	Kdo2-lipid A biosynthetic process
L2Z40_RS04670	COG1280	lysine exporter protein (LysE YggA)
L2Z40_RS04675	COG0488	(ABC) transporter
L2Z40_RS04680	COG2900	Belongs to the SlyX family
L2Z40_RS04690	COG1733	regulation of RNA biosynthetic process
L2Z40_RS04715	COG0210	DNA helicase
L2Z40_RS04720	COG0724	RNA recognition motif
L2Z40_RS04740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z40_RS04740	COG4651	solute:proton antiporter activity
L2Z40_RS04765	COG0788	formyltetrahydrofolate deformylase activity
L2Z40_RS04865	COG2813	Specifically methylates the guanine in position
L2Z40_RS04865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z40_RS04875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z40_RS04885	COG4774	siderophore transport
L2Z40_RS04895	COG0740	serine-type endopeptidase activity
L2Z40_RS04915	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z40_RS04915	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z40_RS04920	COG0280	phosphate acetyltransferase
L2Z40_RS04920	COG0857	belongs to the CobB CobQ family
L2Z40_RS04925	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Z40_RS04935	COG0800	Aldolase
L2Z40_RS04945	COG3265	gluconokinase activity
L2Z40_RS04950	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_RS04960	COG2267	carboxylic ester hydrolase activity
L2Z40_RS04975	COG0793	Belongs to the peptidase S41A family
L2Z40_RS05010	COG1426	Protein conserved in bacteria
L2Z40_RS05050	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2Z40_RS05060	COG1162	GTPase activity
L2Z40_RS05065	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Z40_RS05080	COG1538	Outer membrane efflux protein
L2Z40_RS05085	COG1136	(ABC) transporter
L2Z40_RS05085	COG0577	efflux transmembrane transporter activity
L2Z40_RS05090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z40_RS05115	COG0028	Belongs to the TPP enzyme family
L2Z40_RS05120	COG0440	acetolactate synthase activity
L2Z40_RS05135	COG3676	manually curated
L2Z40_RS05155	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Z40_RS05170	COG0084	hydrolase, TatD family'
L2Z40_RS05180	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Z40_RS05190	COG0583	DNA-binding transcription factor activity
L2Z40_RS05200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z40_RS05290	COG2205	protein histidine kinase activity
L2Z40_RS05305	COG2132	Multicopper oxidase
L2Z40_RS05325	COG2814	Major facilitator Superfamily
L2Z40_RS05335	COG0697	spore germination
L2Z40_RS05365	COG3622	Belongs to the hyi family
L2Z40_RS05370	COG2084	Dehydrogenase
L2Z40_RS05375	COG1024	Enoyl-CoA hydratase
L2Z40_RS05380	COG0784	Response regulator, receiver
L2Z40_RS05380	COG2205	protein histidine kinase activity
L2Z40_RS05380	COG5002	protein histidine kinase activity
L2Z40_RS05400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z40_RS05410	COG3956	TIGRFAM MazG family protein
L2Z40_RS05415	COG1555	photosystem II stabilization
L2Z40_RS05420	COG0617	tRNA 3'-terminal CCA addition
L2Z40_RS05425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Z40_RS05445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z40_RS05450	COG3028	Belongs to the UPF0307 family
L2Z40_RS05455	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z40_RS05470	COG0625	glutathione transferase activity
L2Z40_RS05475	COG1238	metal cluster binding
L2Z40_RS05515	COG0072	phenylalanine-tRNA ligase activity
L2Z40_RS05545	COG0248	Ppx GppA phosphatase
L2Z40_RS05555	COG0037	tRNA processing
L2Z40_RS05595	COG1764	response to oxidative stress
L2Z40_RS05600	COG1846	Transcriptional regulator
L2Z40_RS05610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z40_RS05670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2Z40_RS05675	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Z40_RS05680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Z40_RS05690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L2Z40_RS05740	COG1214	PFAM Peptidase M22, glycoprotease
L2Z40_RS05755	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
L2Z40_RS05765	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z40_RS05770	COG0561	phosphatase activity
L2Z40_RS05780	COG2132	Multicopper oxidase
L2Z40_RS05785	COG3667	copper resistance
L2Z40_RS05800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z40_RS05805	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Z40_RS05810	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Z40_RS05840	COG1063	alcohol dehydrogenase
L2Z40_RS05845	COG0583	DNA-binding transcription factor activity
L2Z40_RS05850	COG1960	acyl-CoA dehydrogenase activity
L2Z40_RS05855	COG2814	Major facilitator Superfamily
L2Z40_RS05860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z40_RS05870	COG1053	succinate dehydrogenase
L2Z40_RS05875	COG0583	DNA-binding transcription factor activity
L2Z40_RS05890	COG0583	DNA-binding transcription factor activity
L2Z40_RS05920	COG0583	DNA-binding transcription factor activity
L2Z40_RS05935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z40_RS05940	COG1309	transcriptional regulator
L2Z40_RS05970	COG0384	phenazine biosynthesis protein PhzF
L2Z40_RS05980	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Z40_RS06000	COG0745	RESPONSE REGULATOR receiver
L2Z40_RS06040	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Z40_RS06070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z40_RS06075	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Z40_RS06100	COG0583	DNA-binding transcription factor activity
L2Z40_RS06120	COG0668	transmembrane transport
L2Z40_RS06130	COG2081	HI0933 family
L2Z40_RS06135	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z40_RS06165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z40_RS06165	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z40_RS06175	COG0489	protein tyrosine kinase activity
L2Z40_RS06225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z40_RS06235	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Z40_RS06250	COG0730	response to heat
L2Z40_RS06260	COG1196	nuclear chromosome segregation
L2Z40_RS06280	COG2223	nitrite transmembrane transporter activity
L2Z40_RS06285	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2Z40_RS06295	COG0596	Alpha beta hydrolase
L2Z40_RS06295	COG2226	methyltransferase
L2Z40_RS06295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z40_RS06310	COG4106	trans-aconitate 2-methyltransferase activity
L2Z40_RS06325	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Z40_RS06330	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2Z40_RS06335	COG0009	L-threonylcarbamoyladenylate synthase
L2Z40_RS06340	COG3101	peptidyl-lysine hydroxylation
L2Z40_RS06345	COG1399	metal-binding, possibly nucleic acid-binding protein
L2Z40_RS06370	COG1652	LysM domain
L2Z40_RS06375	COG0351	phosphomethylpyrimidine kinase
L2Z40_RS06375	COG0352	thiamine-phosphate diphosphorylase activity
L2Z40_RS06375	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z40_RS06385	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2Z40_RS06415	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z40_RS06445	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Z40_RS06460	COG0358	DNA primase activity
L2Z40_RS06470	COG0564	pseudouridine synthase activity
L2Z40_RS06495	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z40_RS06515	COG0583	DNA-binding transcription factor activity
L2Z40_RS06520	COG0473	3-isopropylmalate dehydrogenase activity
L2Z40_RS06530	COG0657	acetylesterase activity
L2Z40_RS06540	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_RS06560	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Z40_RS06560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z40_RS06575	COG1981	membrane
L2Z40_RS06620	COG0456	acetyltransferase
L2Z40_RS06630	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Z40_RS06635	COG0492	ferredoxin-NADP+ reductase activity
L2Z40_RS06640	COG1674	ftsk spoiiie
L2Z40_RS06640	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Z40_RS06645	COG1280	lysine exporter protein (LysE YggA)
L2Z40_RS06660	COG2894	cell division
L2Z40_RS06675	COG0204	Acyl-transferase
L2Z40_RS06680	COG2885	chlorophyll binding
L2Z40_RS06685	COG0210	DNA helicase
L2Z40_RS06695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z40_RS06710	COG0121	glutamine amidotransferase
L2Z40_RS06730	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z40_RS06735	COG0735	belongs to the Fur family
L2Z40_RS06760	COG0420	3'-5' exonuclease activity
L2Z40_RS06780	COG1090	epimerase
L2Z40_RS06795	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z40_RS06805	COG2814	Major facilitator Superfamily
L2Z40_RS06810	COG0405	Gamma-glutamyltransferase
L2Z40_RS06820	COG0582	viral genome integration into host DNA
L2Z40_RS06875	COG0629	single-stranded DNA binding
L2Z40_RS06915	COG0084	hydrolase, TatD family'
L2Z40_RS06935	COG0477	Major facilitator Superfamily
L2Z40_RS06940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z40_RS06950	COG1595	DNA-templated transcription, initiation
L2Z40_RS07005	COG0531	amino acid
L2Z40_RS07010	COG2040	homocysteine
L2Z40_RS07040	COG1309	transcriptional regulator
L2Z40_RS07045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z40_RS07050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z40_RS07060	COG1607	acyl-coa hydrolase
L2Z40_RS07070	COG0523	cobalamin synthesis protein
L2Z40_RS07080	COG4681	YaeQ
L2Z40_RS07090	COG0726	polysaccharide deacetylase
L2Z40_RS07090	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z40_RS07095	COG1215	transferase activity, transferring glycosyl groups
L2Z40_RS07105	COG1024	Enoyl-CoA hydratase
L2Z40_RS07120	COG1414	Transcriptional regulator
L2Z40_RS07140	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_RS07150	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z40_RS07155	COG2271	Major facilitator Superfamily
L2Z40_RS07165	COG2267	carboxylic ester hydrolase activity
L2Z40_RS07170	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_RS07185	COG0028	Belongs to the TPP enzyme family
L2Z40_RS07195	COG0477	Major facilitator Superfamily
L2Z40_RS07200	COG0242	peptide deformylase activity
L2Z40_RS07205	COG2066	Belongs to the glutaminase family
L2Z40_RS07210	COG2207	Transcriptional regulator
L2Z40_RS07215	COG2223	nitrite transmembrane transporter activity
L2Z40_RS07230	COG0583	DNA-binding transcription factor activity
L2Z40_RS07235	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_RS07240	COG2271	Major facilitator Superfamily
L2Z40_RS07245	COG3959	Transketolase, thiamine diphosphate binding domain
L2Z40_RS07250	COG3958	Transketolase
L2Z40_RS07260	COG0306	phosphate transporter
L2Z40_RS07280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z40_RS07325	COG4181	ATPase activity
L2Z40_RS07330	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Z40_RS07360	COG0583	DNA-binding transcription factor activity
L2Z40_RS07370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z40_RS07375	COG1773	rubredoxin
L2Z40_RS07425	COG2851	Citrate transporter
L2Z40_RS07430	COG1253	flavin adenine dinucleotide binding
L2Z40_RS07470	COG0804	urea catabolic process
L2Z40_RS07480	COG0830	nickel cation binding
L2Z40_RS07495	COG0742	ribosomal rna small subunit methyltransferase
L2Z40_RS07500	COG0768	penicillin binding
L2Z40_RS07525	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Z40_RS07530	COG2878	Part of a membrane complex involved in electron transport
L2Z40_RS07535	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z40_RS07545	COG3384	dioxygenase
L2Z40_RS07565	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2Z40_RS07605	COG0006	proline dipeptidase activity
L2Z40_RS07610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z40_RS07615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z40_RS07635	COG1279	arginine transmembrane transporter activity
L2Z40_RS07640	COG0583	DNA-binding transcription factor activity
L2Z40_RS07680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z40_RS07685	COG0741	lytic transglycosylase activity
L2Z40_RS07685	COG1388	LysM domain
L2Z40_RS07685	COG0741	lytic transglycosylase activity
L2Z40_RS07685	COG1388	LysM domain
L2Z40_RS07695	COG4174	ABC transporter (Permease)
L2Z40_RS07700	COG4239	(ABC) transporter, permease
L2Z40_RS07705	COG4172	Belongs to the ABC transporter superfamily
L2Z40_RS07755	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z40_RS07765	COG4251	negative regulation of phosphorylation
L2Z40_RS07765	COG2203	Gaf domain
L2Z40_RS07765	COG3706	GGDEF domain
L2Z40_RS07765	COG5001	Diguanylate cyclase
L2Z40_RS07775	COG1902	pentaerythritol trinitrate reductase activity
L2Z40_RS07775	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z40_RS07810	COG3209	COG3209 Rhs family protein
L2Z40_RS07845	COG1113	amino acid transport
L2Z40_RS07855	COG0531	amino acid
L2Z40_RS07875	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_RS07895	COG1113	amino acid transport
L2Z40_RS07925	COG0697	spore germination
L2Z40_RS07930	COG2721	sulfolactate sulfo-lyase activity
L2Z40_RS07935	COG2271	Major facilitator Superfamily
L2Z40_RS07940	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z40_RS07950	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_RS07955	COG2186	Transcriptional regulator
L2Z40_RS07980	COG1960	acyl-CoA dehydrogenase activity
L2Z40_RS07990	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_RS07995	COG1024	Enoyl-CoA hydratase
L2Z40_RS08000	COG2814	Major facilitator Superfamily
L2Z40_RS08015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z40_RS08060	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
L2Z40_RS08065	COG2072	flavoprotein involved in K transport
L2Z40_RS08070	COG0300	oxidoreductase activity
L2Z40_RS08080	COG1309	transcriptional regulator
L2Z40_RS08085	COG1741	Belongs to the pirin family
L2Z40_RS08100	COG2072	flavoprotein involved in K transport
L2Z40_RS08110	COG2252	PERMEase
L2Z40_RS08115	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2Z40_RS08120	COG3038	cytochrome b561
L2Z40_RS08130	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2Z40_RS08140	COG0527	aspartate kinase activity
L2Z40_RS08150	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Z40_RS08160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Z40_RS08175	COG0667	Aldo Keto reductase
L2Z40_RS08190	COG1765	OsmC-like protein
L2Z40_RS08205	COG0542	response to heat
L2Z40_RS08240	COG2885	chlorophyll binding
L2Z40_RS08250	COG0625	glutathione transferase activity
L2Z40_RS08255	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2Z40_RS08275	COG3634	alkyl hydroperoxide reductase activity
L2Z40_RS08295	COG0450	alkyl hydroperoxide reductase
L2Z40_RS08300	COG1643	Atp-dependent helicase
L2Z40_RS08315	COG2814	Major facilitator Superfamily
L2Z40_RS08320	COG3135	benzoate transporter
L2Z40_RS08325	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_RS08330	COG0633	Ferredoxin
L2Z40_RS08330	COG0543	2 iron, 2 sulfur cluster binding
L2Z40_RS08340	COG4638	Rieske (2fe-2S)
L2Z40_RS08350	COG0583	DNA-binding transcription factor activity
L2Z40_RS08400	COG1570	exodeoxyribonuclease VII activity
L2Z40_RS08430	COG1280	lysine exporter protein (LysE YggA)
L2Z40_RS08435	COG1278	Cold shock
L2Z40_RS08470	COG2814	Major facilitator Superfamily
L2Z40_RS08545	COG5410	chromosome segregation
L2Z40_RS08550	COG3567	Phage-associated protein, HI1409 family
L2Z40_RS08570	COG3566	protein conserved in bacteria
L2Z40_RS08585	COG5434	Belongs to the glycosyl hydrolase 28 family
L2Z40_RS08620	COG3676	manually curated
L2Z40_RS08655	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Z40_RS08665	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2Z40_RS08670	COG1137	ATPase activity
L2Z40_RS08675	COG1538	Outer membrane efflux protein
L2Z40_RS08705	COG4122	O-methyltransferase activity
L2Z40_RS08715	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2Z40_RS08730	COG1522	sequence-specific DNA binding
L2Z40_RS08735	COG5006	permease, DMT superfamily
L2Z40_RS08745	COG1560	Kdo2-lipid A biosynthetic process
L2Z40_RS08760	COG2814	Major facilitator Superfamily
L2Z40_RS08780	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z40_RS08825	COG3209	COG3209 Rhs family protein
L2Z40_RS08845	COG0583	DNA-binding transcription factor activity
L2Z40_RS08850	COG1914	H( )-stimulated, divalent metal cation uptake system
L2Z40_RS08870	COG4770	biotin carboxylase activity
L2Z40_RS08875	COG0038	chloride channel
L2Z40_RS08900	COG1309	transcriptional regulator
L2Z40_RS08910	COG1063	alcohol dehydrogenase
L2Z40_RS08925	COG0439	Biotin carboxylase
L2Z40_RS08930	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z40_RS08935	COG1733	regulation of RNA biosynthetic process
L2Z40_RS08945	COG0864	Transcriptional regulator
L2Z40_RS08955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z40_RS08960	COG1116	anion transmembrane transporter activity
L2Z40_RS09080	COG0590	tRNA wobble adenosine to inosine editing
L2Z40_RS09085	COG2807	transmembrane transport
L2Z40_RS09100	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2Z40_RS09110	COG0789	Transcriptional regulator
L2Z40_RS09120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z40_RS09140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z40_RS09165	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_RS09170	COG0531	amino acid
L2Z40_RS09175	COG1760	l-serine dehydratase
L2Z40_RS09180	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_RS09180	COG2030	dehydratase
L2Z40_RS09185	COG3396	Phenylacetate-CoA oxygenase
L2Z40_RS09190	COG3460	Phenylacetate-CoA oxygenase
L2Z40_RS09195	COG3396	Phenylacetate-CoA oxygenase
L2Z40_RS09200	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Z40_RS09205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z40_RS09210	COG1024	Enoyl-CoA hydratase
L2Z40_RS09215	COG1024	Enoyl-CoA hydratase
L2Z40_RS09220	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z40_RS09225	COG0183	Belongs to the thiolase family
L2Z40_RS09230	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L2Z40_RS09235	COG3327	negative regulation of DNA-templated transcription, initiation
L2Z40_RS09245	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z40_RS09250	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L2Z40_RS09255	COG0210	DNA helicase
L2Z40_RS09290	COG1278	Cold shock
L2Z40_RS09320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z40_RS09325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z40_RS09330	COG2271	Major facilitator Superfamily
L2Z40_RS09340	COG3038	cytochrome b561
L2Z40_RS09360	COG2267	carboxylic ester hydrolase activity
L2Z40_RS09365	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z40_RS09370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z40_RS09375	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_RS09385	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z40_RS09395	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_RS09400	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z40_RS09405	COG0583	DNA-binding transcription factor activity
L2Z40_RS09415	COG1414	Transcriptional regulator
L2Z40_RS09420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z40_RS09430	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Z40_RS09435	COG3842	ATPase activity
L2Z40_RS09450	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Z40_RS09455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z40_RS09460	COG2814	Major facilitator Superfamily
L2Z40_RS09465	COG1960	acyl-CoA dehydrogenase activity
L2Z40_RS09470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z40_RS09480	COG1024	Enoyl-CoA hydratase
L2Z40_RS09490	COG2814	Major facilitator Superfamily
L2Z40_RS09500	COG0183	Belongs to the thiolase family
L2Z40_RS09505	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z40_RS09510	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_RS09515	COG1024	Enoyl-CoA hydratase
L2Z40_RS09520	COG1960	acyl-CoA dehydrogenase activity
L2Z40_RS09525	COG2814	Major facilitator Superfamily
L2Z40_RS09530	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z40_RS09535	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z40_RS09545	COG2814	Major facilitator Superfamily
L2Z40_RS09555	COG1960	acyl-CoA dehydrogenase activity
L2Z40_RS09570	COG0583	DNA-binding transcription factor activity
L2Z40_RS09580	COG4770	biotin carboxylase activity
L2Z40_RS09585	COG1024	Enoyl-CoA hydratase
L2Z40_RS09590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z40_RS09595	COG1960	acyl-CoA dehydrogenase activity
L2Z40_RS09600	COG1309	transcriptional regulator
L2Z40_RS09605	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z40_RS09625	COG0583	DNA-binding transcription factor activity
L2Z40_RS09675	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_RS09715	COG0784	Response regulator, receiver
L2Z40_RS09715	COG2205	protein histidine kinase activity
L2Z40_RS09735	COG0765	amino acid transport
L2Z40_RS09740	COG0765	amino acid transport
L2Z40_RS09745	COG1126	abc transporter atp-binding protein
L2Z40_RS09750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z40_RS09755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z40_RS09770	COG1280	lysine exporter protein (LysE YggA)
L2Z40_RS09780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2Z40_RS09785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z40_RS09790	COG1045	serine acetyltransferase
L2Z40_RS09805	COG0583	DNA-binding transcription factor activity
L2Z40_RS09810	COG0625	glutathione transferase activity
L2Z40_RS09815	COG0625	glutathione transferase activity
L2Z40_RS09820	COG0583	DNA-binding transcription factor activity
L2Z40_RS09830	COG1346	cytolysis
L2Z40_RS09835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z40_RS09850	COG2814	Major facilitator Superfamily
L2Z40_RS09860	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2Z40_RS09865	COG3052	prosthetic group binding
L2Z40_RS09885	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Z40_RS09905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z40_RS09915	COG1294	oxidase, subunit
L2Z40_RS09920	COG1271	oxidase subunit
L2Z40_RS09945	COG0477	Major facilitator Superfamily
L2Z40_RS09955	COG4521	taurine ABC transporter
L2Z40_RS09960	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2Z40_RS09965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z40_RS09970	COG2175	clavaminate synthase activity
L2Z40_RS09980	COG1953	Uracil, thiamine, allantoin
L2Z40_RS09990	COG0583	DNA-binding transcription factor activity
L2Z40_RS10000	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L2Z40_RS10015	COG0640	Transcriptional regulator
L2Z40_RS10020	COG0798	PFAM Bile acid sodium symporter
L2Z40_RS10025	COG0583	DNA-binding transcription factor activity
L2Z40_RS10040	COG3634	alkyl hydroperoxide reductase activity
L2Z40_RS10075	COG1301	dicarboxylic acid transport
L2Z40_RS10080	COG0436	Aminotransferase
L2Z40_RS10090	COG0386	Belongs to the glutathione peroxidase family
L2Z40_RS10130	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z40_RS10155	COG0012	GTP binding
L2Z40_RS10160	COG2011	ABC-type metal ion transport system permease component
L2Z40_RS10165	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z40_RS10175	COG1464	Belongs to the NlpA lipoprotein family
L2Z40_RS10205	COG0765	amino acid transport
L2Z40_RS10210	COG0765	amino acid transport
L2Z40_RS10215	COG1126	abc transporter atp-binding protein
L2Z40_RS10225	COG1522	sequence-specific DNA binding
L2Z40_RS10240	COG1309	transcriptional regulator
L2Z40_RS10260	COG0583	DNA-binding transcription factor activity
L2Z40_RS10270	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z40_RS10280	COG0697	spore germination
L2Z40_RS10305	COG3121	Chaperone
L2Z40_RS10310	COG3539	Fimbrial protein
L2Z40_RS10335	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Z40_RS10335	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Z40_RS10360	COG3676	manually curated
L2Z40_RS10390	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Z40_RS10405	COG2353	YceI-like domain
L2Z40_RS10415	COG3698	Phosphodiester glycosidase
L2Z40_RS10430	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2Z40_RS10435	COG0506	proline dehydrogenase activity
L2Z40_RS10435	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z40_RS10435	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z40_RS10445	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z40_RS10450	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Z40_RS10470	COG1132	(ABC) transporter
L2Z40_RS10475	COG3122	Protein conserved in bacteria
L2Z40_RS10480	COG3619	membrane
L2Z40_RS10490	COG0640	Transcriptional regulator
L2Z40_RS10500	COG2850	peptidyl-arginine hydroxylation
L2Z40_RS10505	COG0424	maF-like protein
L2Z40_RS10525	COG0191	fructose-bisphosphate aldolase activity
L2Z40_RS10530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z40_RS10545	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z40_RS10555	COG1192	Involved in chromosome partitioning
L2Z40_RS10560	COG1475	DNA binding
L2Z40_RS10565	COG0811	peptide transport
L2Z40_RS10575	COG1132	(ABC) transporter
L2Z40_RS10580	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Z40_RS10600	COG0084	hydrolase, TatD family'
L2Z40_RS10665	COG0776	regulation of translation
L2Z40_RS10695	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Z40_RS10700	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Z40_RS10725	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
L2Z40_RS10745	COG0339	signal peptide processing
L2Z40_RS10755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Z40_RS10790	COG0702	epimerase
L2Z40_RS10795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z40_RS10815	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Z40_RS10845	COG0316	Belongs to the HesB IscA family
L2Z40_RS10850	COG0822	iron-sulfur transferase activity
L2Z40_RS10875	COG0776	regulation of translation
L2Z40_RS10880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z40_RS10885	COG2207	Transcriptional regulator
L2Z40_RS10890	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z40_RS10895	COG1960	acyl-CoA dehydrogenase activity
L2Z40_RS10900	COG1960	acyl-CoA dehydrogenase activity
L2Z40_RS10915	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Z40_RS10930	COG2814	Major facilitator Superfamily
L2Z40_RS10935	COG4264	IucA IucC family
L2Z40_RS10940	COG4264	IucA IucC family
L2Z40_RS10950	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z40_RS10980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z40_RS10995	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2Z40_RS11000	COG0406	alpha-ribazole phosphatase activity
L2Z40_RS11015	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Z40_RS11020	COG0730	response to heat
L2Z40_RS11040	COG4773	Receptor
L2Z40_RS11045	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z40_RS11100	COG2226	methyltransferase
L2Z40_RS11125	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Z40_RS11160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z40_RS11170	COG0133	tryptophan synthase activity
L2Z40_RS11185	COG3706	GGDEF domain
L2Z40_RS11200	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z40_RS11205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2Z40_RS11210	COG0022	dehydrogenase e1 component
L2Z40_RS11215	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z40_RS11220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z40_RS11230	COG1063	alcohol dehydrogenase
L2Z40_RS11235	COG3781	membrane
L2Z40_RS11245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z40_RS11245	COG3453	Protein conserved in bacteria
L2Z40_RS11260	COG0730	response to heat
L2Z40_RS11275	COG2207	Transcriptional regulator
L2Z40_RS11275	COG3708	Transcriptional regulator
L2Z40_RS11280	COG1733	regulation of RNA biosynthetic process
L2Z40_RS11285	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Z40_RS11295	COG2188	Transcriptional regulator
L2Z40_RS11310	COG4521	taurine ABC transporter
L2Z40_RS11315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z40_RS11335	COG0477	Major facilitator Superfamily
L2Z40_RS11345	COG1027	Aspartate ammonia-lyase
L2Z40_RS11360	COG0583	DNA-binding transcription factor activity
L2Z40_RS11365	COG0583	DNA-binding transcription factor activity
L2Z40_RS11370	COG0183	Belongs to the thiolase family
L2Z40_RS11375	COG2031	fatty acid transporter
L2Z40_RS11390	COG0583	DNA-binding transcription factor activity
L2Z40_RS11400	COG2610	gluconate transmembrane transporter activity
L2Z40_RS11405	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_RS11410	COG2207	Transcriptional regulator
L2Z40_RS11425	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_RS11435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z40_RS11450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z40_RS11450	COG0543	2 iron, 2 sulfur cluster binding
L2Z40_RS11455	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z40_RS11460	COG4638	Rieske (2fe-2S)
L2Z40_RS11470	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2Z40_RS11475	COG4149	molybdate abc transporter
L2Z40_RS11480	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2Z40_RS11485	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_RS11490	COG3433	isochorismatase activity
L2Z40_RS11490	COG1535	isochorismatase
L2Z40_RS11555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z40_RS11570	COG0753	catalase activity
L2Z40_RS11580	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L2Z40_RS11605	COG3539	Fimbrial protein
L2Z40_RS11645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z40_RS11655	COG2072	flavoprotein involved in K transport
L2Z40_RS11665	COG1538	Outer membrane efflux protein
L2Z40_RS11670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z40_RS11675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z40_RS11680	COG0745	RESPONSE REGULATOR receiver
L2Z40_RS11685	COG2205	protein histidine kinase activity
L2Z40_RS11695	COG2207	Transcriptional regulator
L2Z40_RS11710	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_RS11720	COG1073	alpha beta
L2Z40_RS11755	COG3676	manually curated
L2Z40_RS11760	COG0556	nucleotide-excision repair
L2Z40_RS11775	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2Z40_RS11840	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z40_RS11855	COG2084	Dehydrogenase
L2Z40_RS11865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z40_RS11870	COG0583	DNA-binding transcription factor activity
L2Z40_RS11880	COG0129	dihydroxy-acid dehydratase activity
L2Z40_RS11885	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_RS11900	COG1566	PFAM secretion protein HlyD family protein
L2Z40_RS11915	COG0583	DNA-binding transcription factor activity
L2Z40_RS11930	COG2188	Transcriptional regulator
L2Z40_RS11990	COG1473	amidohydrolase
L2Z40_RS12000	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z40_RS12000	COG0475	glutathione-regulated potassium exporter activity
L2Z40_RS12010	COG0583	DNA-binding transcription factor activity
L2Z40_RS12015	COG1335	isochorismatase
L2Z40_RS12035	COG1902	pentaerythritol trinitrate reductase activity
L2Z40_RS12045	COG4689	acetoacetate decarboxylase
L2Z40_RS12050	COG4221	oxidoreductase activity
L2Z40_RS12060	COG1309	transcriptional regulator
L2Z40_RS12100	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z40_RS12100	COG1902	pentaerythritol trinitrate reductase activity
L2Z40_RS12115	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_RS12135	COG2186	Transcriptional regulator
L2Z40_RS12145	COG0583	DNA-binding transcription factor activity
L2Z40_RS12150	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z40_RS12155	COG4829	muconolactone delta-isomerase
L2Z40_RS12165	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z40_RS12170	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z40_RS12175	COG0183	Belongs to the thiolase family
L2Z40_RS12180	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z40_RS12190	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_RS12200	COG3733	amine oxidase
L2Z40_RS12210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z40_RS12220	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_RS12230	COG4638	Rieske (2fe-2S)
L2Z40_RS12250	COG0154	amidase activity
L2Z40_RS12260	COG2814	Major facilitator Superfamily
L2Z40_RS12285	COG1960	acyl-CoA dehydrogenase activity
L2Z40_RS12290	COG0583	DNA-binding transcription factor activity
L2Z40_RS12295	COG1414	Transcriptional regulator
L2Z40_RS12310	COG2391	methyltransferase activity
L2Z40_RS12320	COG4993	Dehydrogenase
L2Z40_RS12325	COG3659	wide pore channel activity
L2Z40_RS12330	COG3420	alginic acid biosynthetic process
L2Z40_RS12335	COG0710	3-dehydroquinate dehydratase activity
L2Z40_RS12340	COG3485	protocatechuate 3,4-dioxygenase
L2Z40_RS12345	COG3485	protocatechuate 3,4-dioxygenase
L2Z40_RS12350	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z40_RS12355	COG2271	Major facilitator Superfamily
L2Z40_RS12360	COG0596	Alpha beta hydrolase
L2Z40_RS12365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Z40_RS12370	COG0183	Belongs to the thiolase family
L2Z40_RS12375	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z40_RS12380	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z40_RS12390	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Z40_RS12395	COG2323	membrane
L2Z40_RS12440	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z40_RS12440	COG1902	pentaerythritol trinitrate reductase activity
L2Z40_RS12465	COG0542	response to heat
L2Z40_RS12470	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Z40_RS12500	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z40_RS12505	COG0569	domain protein
L2Z40_RS12510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Z40_RS12525	COG4774	siderophore transport
L2Z40_RS12530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Z40_RS12540	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2Z40_RS12555	COG1294	oxidase, subunit
L2Z40_RS12560	COG4890	Cyd operon protein YbgT
L2Z40_RS12570	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2Z40_RS12580	COG0552	protein localization to endoplasmic reticulum
L2Z40_RS12605	COG0516	GMP reductase activity
L2Z40_RS12605	COG0517	IMP dehydrogenase activity
L2Z40_RS12610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z40_RS12615	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Z40_RS12625	COG0583	DNA-binding transcription factor activity
L2Z40_RS12630	COG0024	Methionine aminopeptidase
L2Z40_RS12660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Z40_RS12660	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z40_RS12665	COG1105	Belongs to the carbohydrate kinase PfkB family
L2Z40_RS12670	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z40_RS12670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z40_RS12670	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2Z40_RS12705	COG2135	peptidase activity
L2Z40_RS12710	COG0659	secondary active sulfate transmembrane transporter activity
L2Z40_RS12730	COG1113	amino acid transport
L2Z40_RS12765	COG1011	Hydrolase
L2Z40_RS12770	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Z40_RS12780	COG2137	regulation of response to DNA damage stimulus
L2Z40_RS12795	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z40_RS12830	COG0575	Belongs to the CDS family
L2Z40_RS12835	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Z40_RS12860	COG3852	Histidine kinase
L2Z40_RS12865	COG2204	response regulator
L2Z40_RS12920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z40_RS12925	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Z40_RS12945	COG0697	spore germination
L2Z40_RS12965	COG0303	'Molybdopterin
L2Z40_RS12970	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Z40_RS12970	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Z40_RS12985	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Z40_RS12990	COG0243	molybdopterin cofactor binding
L2Z40_RS13000	COG0243	molybdopterin cofactor binding
L2Z40_RS13005	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z40_RS13010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z40_RS13010	COG2146	nitrite reductase [NAD(P)H] activity
L2Z40_RS13020	COG0745	RESPONSE REGULATOR receiver
L2Z40_RS13025	COG1116	anion transmembrane transporter activity
L2Z40_RS13025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z40_RS13045	COG0511	ligase activity, forming carbon-carbon bonds
L2Z40_RS13060	COG2814	Major facilitator Superfamily
L2Z40_RS13080	COG0069	glutamate synthase activity
L2Z40_RS13100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Z40_RS13110	COG1454	alcohol dehydrogenase
L2Z40_RS13115	COG0824	Thioesterase
L2Z40_RS13125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z40_RS13140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z40_RS13145	COG2030	dehydratase
L2Z40_RS13155	COG0183	Belongs to the thiolase family
L2Z40_RS13165	COG0583	DNA-binding transcription factor activity
L2Z40_RS13170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z40_RS13180	COG1522	sequence-specific DNA binding
L2Z40_RS13185	COG3135	benzoate transporter
L2Z40_RS13195	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Z40_RS13215	COG0589	response to stress
L2Z40_RS13220	COG0488	(ABC) transporter
L2Z40_RS13240	COG4773	Receptor
L2Z40_RS13270	COG0668	transmembrane transport
L2Z40_RS13280	COG1309	transcriptional regulator
L2Z40_RS13295	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L2Z40_RS13310	COG1605	Chorismate mutase
L2Z40_RS13350	COG0308	aminopeptidase N
L2Z40_RS13375	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z40_RS13380	COG1454	alcohol dehydrogenase
L2Z40_RS13400	COG0531	amino acid
L2Z40_RS13405	COG4303	Ethanolamine ammonia lyase large subunit
L2Z40_RS13410	COG4302	ethanolamine ammonia-lyase activity
L2Z40_RS13415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z40_RS13415	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z40_RS13420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z40_RS13445	COG0697	spore germination
L2Z40_RS13450	COG1923	regulation of RNA biosynthetic process
L2Z40_RS13460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Z40_RS13465	COG0802	atpase or kinase
L2Z40_RS13485	COG1187	pseudouridine synthase activity
L2Z40_RS13500	COG0583	DNA-binding transcription factor activity
L2Z40_RS13515	COG2814	Major facilitator Superfamily
L2Z40_RS13520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z40_RS13545	COG0729	surface antigen
L2Z40_RS13565	COG0174	glutamine synthetase
L2Z40_RS13570	COG0745	RESPONSE REGULATOR receiver
L2Z40_RS13575	COG2205	protein histidine kinase activity
L2Z40_RS13585	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2Z40_RS13590	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2Z40_RS13615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z40_RS13620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z40_RS13625	COG1960	acyl-CoA dehydrogenase activity
L2Z40_RS13640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z40_RS13645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z40_RS13665	COG0583	DNA-binding transcription factor activity
L2Z40_RS13680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z40_RS13690	COG3658	cytochrome
L2Z40_RS13695	COG1215	transferase activity, transferring glycosyl groups
L2Z40_RS13700	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z40_RS13700	COG0726	polysaccharide deacetylase
L2Z40_RS13725	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Z40_RS13730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Z40_RS13740	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2Z40_RS13765	COG0305	Participates in initiation and elongation during chromosome replication
L2Z40_RS13770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Z40_RS13780	COG1305	Transglutaminase-like
L2Z40_RS13790	COG2308	Evidence 4 Homologs of previously reported genes of
L2Z40_RS13820	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Z40_RS13825	COG0138	bifunctional purine biosynthesis protein purh
L2Z40_RS13830	COG0151	Belongs to the GarS family
L2Z40_RS13835	COG1464	Belongs to the NlpA lipoprotein family
L2Z40_RS13840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z40_RS13845	COG2011	ABC-type metal ion transport system permease component
L2Z40_RS13850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z40_RS13860	COG3676	manually curated
L2Z40_RS13865	COG1301	dicarboxylic acid transport
L2Z40_RS13895	COG1794	racemase activity, acting on amino acids and derivatives
L2Z40_RS13915	COG0745	RESPONSE REGULATOR receiver
L2Z40_RS13920	COG0642	Histidine kinase
L2Z40_RS13925	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L2Z40_RS13935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L2Z40_RS13975	COG2351	hydroxyisourate hydrolase activity
L2Z40_RS13985	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Z40_RS13985	COG3008	intermembrane lipid transfer
L2Z40_RS13990	COG2995	paraquat-inducible protein a
L2Z40_RS14015	COG0477	Major facilitator Superfamily
L2Z40_RS14075	COG2186	Transcriptional regulator
L2Z40_RS14090	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_RS14100	COG0583	DNA-binding transcription factor activity
L2Z40_RS14110	COG0786	glutamate:sodium symporter activity
L2Z40_RS14115	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Z40_RS14140	COG3111	PFAM Bacterial OB fold (BOF) protein
L2Z40_RS14240	COG1610	YqeY-like protein
L2Z40_RS14245	COG4783	chaperone-mediated protein folding
L2Z40_RS14270	COG1286	toxin biosynthetic process
L2Z40_RS14300	COG0778	Nitroreductase
L2Z40_RS14310	COG0513	Belongs to the DEAD box helicase family
L2Z40_RS14335	COG2363	Small membrane protein
L2Z40_RS14360	COG1234	tRNA 3'-trailer cleavage
L2Z40_RS14365	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2Z40_RS14375	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Z40_RS14385	COG2819	hydrolase of the alpha beta superfamily
L2Z40_RS14390	COG1960	acyl-CoA dehydrogenase activity
L2Z40_RS14395	COG1301	dicarboxylic acid transport
L2Z40_RS14400	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Z40_RS14405	COG3139	Protein of unknown function (DUF1315)
L2Z40_RS14410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Z40_RS14415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Z40_RS14425	COG0494	nUDIX hydrolase
L2Z40_RS14435	COG0642	Histidine kinase
L2Z40_RS14450	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Z40_RS14460	COG1720	tRNA m6t6A37 methyltransferase activity
L2Z40_RS14475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z40_RS14480	COG0826	peptidase U32
L2Z40_RS14485	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z40_RS14500	COG4160	amino acid transport
L2Z40_RS14505	COG4215	(ABC) transporter
L2Z40_RS14520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z40_RS14625	COG0739	heme binding
L2Z40_RS14745	COG5410	chromosome segregation
L2Z40_RS14845	COG0305	Participates in initiation and elongation during chromosome replication
L2Z40_RS14910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z40_RS14950	COG0582	viral genome integration into host DNA
L2Z40_RS14955	COG1131	(ABC) transporter
L2Z40_RS14960	COG0842	Transport permease protein
L2Z40_RS14975	COG0772	Belongs to the SEDS family
L2Z40_RS14980	COG2951	lytic endotransglycosylase activity
L2Z40_RS15005	COG2207	Transcriptional regulator
L2Z40_RS15020	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Z40_RS15025	COG0024	Methionine aminopeptidase
L2Z40_RS15035	COG2223	nitrite transmembrane transporter activity
L2Z40_RS15045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z40_RS15050	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z40_RS15055	COG1960	acyl-CoA dehydrogenase activity
L2Z40_RS15070	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Z40_RS15075	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Z40_RS15080	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z40_RS15100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z40_RS15105	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2Z40_RS15110	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Z40_RS15145	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Z40_RS15155	COG0174	glutamine synthetase
L2Z40_RS15170	COG0512	Glutamine amidotransferase of anthranilate synthase
L2Z40_RS15205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2Z40_RS15215	COG0302	gtp cyclohydrolase
L2Z40_RS15230	COG3676	manually curated
L2Z40_RS15250	COG3739	integral membrane protein
L2Z40_RS15265	COG1169	isochorismate synthase
L2Z40_RS15275	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z40_RS15280	COG1132	(ABC) transporter
L2Z40_RS15285	COG1132	(ABC) transporter
L2Z40_RS15295	COG3433	isochorismatase activity
L2Z40_RS15295	COG1535	isochorismatase
L2Z40_RS15300	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z40_RS15305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z40_RS15315	COG4774	siderophore transport
L2Z40_RS15320	COG4607	ABC-type enterochelin transport system periplasmic component
L2Z40_RS15325	COG4604	ABC transporter, ATP-binding protein
L2Z40_RS15330	COG4605	iron ion homeostasis
L2Z40_RS15335	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z40_RS15345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z40_RS15360	COG2964	Protein conserved in bacteria
L2Z40_RS15370	COG1741	Belongs to the pirin family
L2Z40_RS15430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z40_RS15430	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2Z40_RS15435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z40_RS15445	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_RS15455	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z40_RS15460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z40_RS15465	COG0006	proline dipeptidase activity
L2Z40_RS15470	COG0006	proline dipeptidase activity
L2Z40_RS15475	COG0583	DNA-binding transcription factor activity
L2Z40_RS15485	COG2879	small protein
L2Z40_RS15490	COG1966	Carbon starvation protein
L2Z40_RS15510	COG4943	cyclic-guanylate-specific phosphodiesterase activity
L2Z40_RS15535	COG1067	ATP-dependent peptidase activity
L2Z40_RS15540	COG0583	DNA-binding transcription factor activity
L2Z40_RS15565	COG1686	Belongs to the peptidase S11 family
L2Z40_RS15570	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Z40_RS15605	COG0616	signal peptide processing
L2Z40_RS15610	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Z40_RS15620	COG0573	inorganic phosphate transmembrane transporter activity
L2Z40_RS15625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Z40_RS15630	COG1113	amino acid transport
L2Z40_RS15635	COG3961	Belongs to the TPP enzyme family
L2Z40_RS15640	COG1522	sequence-specific DNA binding
L2Z40_RS15650	COG0076	glutamate decarboxylase activity
L2Z40_RS15655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z40_RS15665	COG1309	transcriptional regulator
L2Z40_RS15680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z40_RS15715	COG0352	thiamine-phosphate diphosphorylase activity
L2Z40_RS15740	COG1203	CRISPR-associated helicase, Cas3
L2Z40_RS15770	COG0612	Peptidase, M16
L2Z40_RS15780	COG1823	symporter activity
L2Z40_RS15785	COG0583	DNA-binding transcription factor activity
L2Z40_RS15790	COG0477	Major facilitator Superfamily
L2Z40_RS15810	COG1187	pseudouridine synthase activity
L2Z40_RS15825	COG1686	Belongs to the peptidase S11 family
L2Z40_RS15830	COG1252	NADH dehydrogenase
L2Z40_RS15840	COG0415	Belongs to the DNA photolyase family
L2Z40_RS15855	COG1215	transferase activity, transferring glycosyl groups
L2Z40_RS15885	COG2070	2-Nitropropane dioxygenase
L2Z40_RS15940	COG0556	nucleotide-excision repair
L2Z40_RS15965	COG0436	Aminotransferase
L2Z40_RS15995	COG4221	oxidoreductase activity
L2Z40_RS16005	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Z40_RS16010	COG1381	Involved in DNA repair and RecF pathway recombination
L2Z40_RS16020	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Z40_RS16035	COG0681	Belongs to the peptidase S26 family
L2Z40_RS16050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z40_RS16070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Z40_RS16075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2Z40_RS16080	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2Z40_RS16090	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2Z40_RS16095	COG4208	sulfate ABC transporter
L2Z40_RS16100	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2Z40_RS16105	COG0583	DNA-binding transcription factor activity
L2Z40_RS16110	COG4625	pathogenesis
L2Z40_RS16125	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2Z40_RS16140	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Z40_RS16150	COG1056	cytidyltransferase-related domain
L2Z40_RS16150	COG1051	belongs to the nudix hydrolase family
L2Z40_RS16155	COG1024	Enoyl-CoA hydratase
L2Z40_RS16170	COG2814	Major facilitator Superfamily
L2Z40_RS16175	COG0047	phosphoribosylformylglycinamidine synthase activity
L2Z40_RS16175	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2Z40_RS16195	COG1473	amidohydrolase
L2Z40_RS16200	COG0824	Thioesterase
L2Z40_RS16220	COG0823	Involved in the tonB-independent uptake of proteins
L2Z40_RS16240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z40_RS16275	COG0628	permease
L2Z40_RS16285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Z40_RS16290	COG0596	Alpha beta hydrolase
L2Z40_RS16295	COG0616	signal peptide processing
L2Z40_RS16295	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Z40_RS16305	COG2333	competence protein COMEC
L2Z40_RS16305	COG0658	competence protein
L2Z40_RS16310	COG1136	(ABC) transporter
L2Z40_RS16315	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Z40_RS16350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z40_RS16370	COG0463	Glycosyl transferase, family 2
L2Z40_RS16400	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z40_RS16405	COG1280	lysine exporter protein (LysE YggA)
L2Z40_RS16415	COG0019	diaminopimelate decarboxylase activity
L2Z40_RS16425	COG1113	amino acid transport
L2Z40_RS16440	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Z40_RS16450	COG3339	Conserved Protein
L2Z40_RS16455	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2Z40_RS16460	COG0243	molybdopterin cofactor binding
L2Z40_RS16465	COG1929	Belongs to the glycerate kinase type-1 family
L2Z40_RS16480	COG0778	Nitroreductase
L2Z40_RS16510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z40_RS16525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z40_RS16545	COG0741	lytic transglycosylase activity
L2Z40_RS16565	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z40_RS16570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z40_RS16595	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z40_RS16600	COG1597	lipid kinase activity
L2Z40_RS16615	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2Z40_RS16620	COG0477	Major facilitator Superfamily
L2Z40_RS16670	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Z40_RS16675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z40_RS16700	COG0505	Belongs to the CarA family
L2Z40_RS16720	COG0589	response to stress
L2Z40_RS16735	COG2843	Capsule synthesis protein
L2Z40_RS16765	COG2321	neutral zinc metallopeptidase
L2Z40_RS16770	COG2354	Protein conserved in bacteria
L2Z40_RS16800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z40_RS16825	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Z40_RS16830	COG1053	succinate dehydrogenase
L2Z40_RS16835	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Z40_RS16840	COG2009	succinate dehydrogenase
L2Z40_RS16875	COG2921	Belongs to the UPF0250 family
L2Z40_RS16880	COG0321	lipoyl(octanoyl) transferase activity
L2Z40_RS16895	COG0531	amino acid
L2Z40_RS16905	COG1733	regulation of RNA biosynthetic process
L2Z40_RS16910	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Z40_RS16915	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Z40_RS16915	COG1648	precorrin-2 dehydrogenase activity
L2Z40_RS16930	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Z40_RS16960	COG3676	manually curated
L2Z40_RS16965	COG0671	phosphoesterase, PA-phosphatase related
L2Z40_RS16970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z40_RS16980	COG1538	Outer membrane efflux protein
L2Z40_RS16985	COG0393	Putative heavy-metal-binding
L2Z40_RS16990	COG0393	Putative heavy-metal-binding
L2Z40_RS17000	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_RS17010	COG0525	valine-tRNA ligase activity
L2Z40_RS17030	COG0583	DNA-binding transcription factor activity
L2Z40_RS17035	COG0004	ammonium transporteR
L2Z40_RS17045	COG0642	Histidine kinase
L2Z40_RS17050	COG0745	RESPONSE REGULATOR receiver
L2Z40_RS17055	COG2194	sulfuric ester hydrolase activity
L2Z40_RS17070	COG3676	manually curated
L2Z40_RS17085	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z40_RS17100	COG2315	Protein conserved in bacteria
L2Z40_RS17105	COG0142	geranyltranstransferase activity
L2Z40_RS17110	COG2828	Protein conserved in bacteria
L2Z40_RS17115	COG1113	amino acid transport
L2Z40_RS17135	COG2207	Transcriptional regulator
L2Z40_RS17160	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z40_RS17170	COG0560	Phosphoserine phosphatase
L2Z40_RS17180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z40_RS17190	COG1530	ribonuclease E activity
L2Z40_RS17195	COG0424	maF-like protein
L2Z40_RS17200	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2Z40_RS17205	COG1792	Involved in formation and maintenance of cell shape
L2Z40_RS17210	COG1077	Cell shape determining protein MreB Mrl
L2Z40_RS17215	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z40_RS17225	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z40_RS17250	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2Z40_RS17255	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z40_RS17260	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z40_RS17265	COG1115	amino acid carrier protein
L2Z40_RS17285	COG2814	Major facilitator Superfamily
L2Z40_RS17290	COG1289	transmembrane transporter activity
L2Z40_RS17300	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Z40_RS17340	COG1376	ErfK ybiS ycfS ynhG family protein
L2Z40_RS17345	COG2832	Protein of unknown function (DUF454)
L2Z40_RS17355	COG5510	response to toxic substance
L2Z40_RS17370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z40_RS17385	COG0840	transmembrane signaling receptor activity
L2Z40_RS17425	COG3422	double-strand break repair
L2Z40_RS17430	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Z40_RS17435	COG3189	MarR family transcriptional regulator
L2Z40_RS17445	COG0354	folic acid binding
L2Z40_RS17450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z40_RS17460	COG0679	Auxin Efflux Carrier
L2Z40_RS17465	COG1902	pentaerythritol trinitrate reductase activity
L2Z40_RS17470	COG4772	TonB-dependent receptor
L2Z40_RS17475	COG2094	Belongs to the DNA glycosylase MPG family
L2Z40_RS17500	COG1217	gtp-binding protein TYPA
L2Z40_RS17505	COG2233	PERMEase
L2Z40_RS17515	COG0833	amino acid
L2Z40_RS17520	COG1690	Belongs to the RtcB family
L2Z40_RS17530	COG2885	chlorophyll binding
L2Z40_RS17530	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L2Z40_RS17540	COG0183	Belongs to the thiolase family
L2Z40_RS17560	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z40_RS17580	COG2207	Transcriptional regulator
L2Z40_RS17585	COG0183	Belongs to the thiolase family
L2Z40_RS17605	COG2153	protein acetylation
L2Z40_RS17615	COG1272	protein, Hemolysin III
L2Z40_RS17620	COG0477	Major facilitator Superfamily
L2Z40_RS17635	COG0450	alkyl hydroperoxide reductase
L2Z40_RS17655	COG0285	dihydrofolate synthase activity
L2Z40_RS17705	COG2096	Adenosyltransferase
L2Z40_RS17725	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Z40_RS17730	COG0745	RESPONSE REGULATOR receiver
L2Z40_RS17735	COG2205	protein histidine kinase activity
L2Z40_RS17745	COG1960	acyl-CoA dehydrogenase activity
L2Z40_RS17750	COG1960	acyl-CoA dehydrogenase activity
L2Z40_RS17825	COG0438	transferase activity, transferring glycosyl groups
L2Z40_RS17830	COG0463	Glycosyl transferase, family 2
L2Z40_RS17835	COG0726	polysaccharide deacetylase
L2Z40_RS17855	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Z40_RS17860	COG2205	protein histidine kinase activity
L2Z40_RS17865	COG4695	Portal protein
L2Z40_RS18000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L2Z40_RS18010	COG3646	Phage regulatory protein
L2Z40_RS18055	COG0629	single-stranded DNA binding
L2Z40_RS18060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z40_RS18105	COG1862	Preprotein translocase
L2Z40_RS18120	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Z40_RS18130	COG3781	membrane
L2Z40_RS18135	COG0613	PHP domain protein
L2Z40_RS18145	COG2350	Protein conserved in bacteria
L2Z40_RS18175	COG1607	acyl-coa hydrolase
L2Z40_RS18235	COG2199	diguanylate cyclase activity
L2Z40_RS18245	COG1408	metallophosphoesterase
L2Z40_RS18250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z40_RS18260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Z40_RS18280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z40_RS18285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Z40_RS18300	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Z40_RS18310	COG2969	positive regulation of protein catabolic process
L2Z40_RS18330	COG1960	acyl-CoA dehydrogenase activity
L2Z40_RS18335	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z40_RS18350	COG1309	transcriptional regulator
L2Z40_RS18355	COG1960	acyl-CoA dehydrogenase activity
L2Z40_RS18460	COG1002	Type II restriction enzyme, methylase subunits
L2Z40_RS18470	COG0659	secondary active sulfate transmembrane transporter activity
L2Z40_RS18475	COG0589	response to stress
L2Z40_RS18575	COG3853	Toxic anion resistance protein (TelA)
L2Z40_RS18595	COG1475	DNA binding
L2Z40_RS18610	COG1484	DNA-dependent DNA replication
L2Z40_RS18615	COG2390	Transcriptional regulator
L2Z40_RS18615	COG4584	PFAM Integrase catalytic
L2Z40_RS18645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z40_RS18655	COG3676	manually curated
L2Z40_RS18720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z40_RS18800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z40_RS18835	COG0741	lytic transglycosylase activity
L2Z40_RS18850	COG2826	transposase and inactivated derivatives, IS30 family
L2Z40_RS18860	COG2826	transposase and inactivated derivatives, IS30 family