locus-tag class description G3R47_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) G3R47_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3R47_RS00030 ENOG4105DQR SNARE associated Golgi G3R47_RS00035 ENOG4105C5H ABC transporter G3R47_RS00040 ENOG4108821 RND type efflux pump G3R47_RS00045 ENOG4108821 RND type efflux pump G3R47_RS00050 ENOG4108821 RND type efflux pump G3R47_RS00060 ENOG4105D74 hydrolase G3R47_RS00065 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) G3R47_RS00070 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) G3R47_RS00120 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase G3R47_RS00130 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) G3R47_RS00135 ENOG4105DTN riboflavin biosynthesis protein ribF G3R47_RS00145 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) G3R47_RS00150 ENOG4108R86 Transcriptional regulator G3R47_RS00155 ENOG4108VM9 ABC, transporter G3R47_RS00160 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G3R47_RS00165 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G3R47_RS00170 ENOG4105GVF (ABC) transporter G3R47_RS00175 ENOG4105GVF (ABC) transporter G3R47_RS00180 ENOG4107QZM n-acetylglutamate synthase G3R47_RS00195 ENOG4105UBK short-chain dehydrogenase reductase G3R47_RS00200 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) G3R47_RS00210 ENOG4108Z33 Thiol disulfide Interchange Protein G3R47_RS00215 ENOG41062JF Transcriptional regulator G3R47_RS00240 ENOG4105HSS phospholipase C G3R47_RS00250 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase G3R47_RS00255 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase G3R47_RS00260 ENOG4105CJR Integral membrane protein (MviN G3R47_RS00265 ENOG4108V1T peptidylprolyl cis-trans isomerase G3R47_RS00270 ENOG4108V1T peptidylprolyl cis-trans isomerase G3R47_RS00275 ENOG4105D75 Capsular exopolysaccharide family G3R47_RS00285 ENOG4105DAY polysaccharide export protein G3R47_RS00290 ENOG4107QQG Dehydrogenase G3R47_RS00300 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G3R47_RS00305 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase G3R47_RS00310 ENOG4105D2T synthase G3R47_RS00325 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) G3R47_RS00330 ENOG4105F0R Cytidylyltransferase G3R47_RS00370 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase G3R47_RS00385 ENOG4107UKG Glycosyl transferase, family 4 G3R47_RS00390 ENOG4105D3Q Sugar transferase G3R47_RS00395 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G3R47_RS00400 ENOG4105C6Y Udp-glucose 6-dehydrogenase G3R47_RS00410 ENOG4105CMR udp-glucose 4-epimerase G3R47_RS00415 ENOG4107QKV phosphomannomutase G3R47_RS00420 ENOG4105DAA L-lactate G3R47_RS00425 ENOG41073TP transcriptional regulator G3R47_RS00435 ENOG4105CXG d-lactate dehydrogenase G3R47_RS00440 ENOG4105CGF Aromatic amino acid aminotransferase G3R47_RS00450 ENOG4105DRR Transcriptional regulator, GntR family G3R47_RS00455 ENOG4105CR4 methylisocitrate lyase G3R47_RS00460 ENOG4105BZN citrate synthase G3R47_RS00465 ENOG4108I0Z Aconitate hydratase G3R47_RS00550 ENOG4105D3G Pseudouridine synthase G3R47_RS00575 ENOG4105EW9 transcriptional regulator AsnC family G3R47_RS00590 ENOG4105M4H endoribonuclease L-psp G3R47_RS00595 ENOG4105C85 amino acid G3R47_RS00600 ENOG4105C85 amino acid G3R47_RS00610 ENOG4105C26 Dehydrogenase G3R47_RS00615 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3R47_RS00625 ENOG4105C1G acyl-Coa dehydrogenase G3R47_RS00630 ENOG4105E39 Enoyl-CoA hydratase G3R47_RS00635 ENOG4105E39 Enoyl-CoA hydratase G3R47_RS00640 ENOG4105CSH Transporter G3R47_RS00765 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) G3R47_RS00780 ENOG4108BUD transposase G3R47_RS00870 ENOG4105ZTP Protein of unknown function (DUF1376) G3R47_RS00890 ENOG4107NTZ G3R47_RS00905 ENOG4107PSF BolA-like protein G3R47_RS00915 ENOG4107QJE Chromosome Partitioning Protein G3R47_RS00930 ENOG4105DQR SNARE associated Golgi G3R47_RS00935 ENOG4108VBZ doxx family G3R47_RS00940 ENOG4106MP8 UPF0754 membrane protein G3R47_RS00945 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G3R47_RS00965 ENOG4105EUB pirin domain protein G3R47_RS00990 ENOG4107R1I NAD-dependent malic enzyme G3R47_RS01000 ENOG4105EZR dyp-type peroxidase family protein G3R47_RS01005 ENOG410829K Lysine exporter protein (Lyse ygga) G3R47_RS01010 ENOG4105FAV ABC, transporter G3R47_RS01015 ENOG4105FDK ABC transporter G3R47_RS01075 ENOG41090VV Protein of unknown function (DUF2846) G3R47_RS01085 ENOG4108V06 Glutathione peroxidase G3R47_RS01095 ENOG4107RTG Major Facilitator superfamily G3R47_RS01100 ENOG4108IND Tetr family transcriptional regulator G3R47_RS01115 ENOG4105C79 DNA protecting protein DprA G3R47_RS01150 ENOG4105Y7M Transcriptional regulator, TetR family G3R47_RS01185 ENOG4105C6T cysteine synthase G3R47_RS01195 ENOG4105CS1 NAD(P)H quinone oxidoreductase G3R47_RS01215 ENOG4105CCT upf0313 protein G3R47_RS01230 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G3R47_RS01240 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3R47_RS01245 ENOG4108URH decarboxylase G3R47_RS01250 ENOG4105EE5 Membrane protein terC G3R47_RS01255 ENOG4105K5B UPF0225 protein G3R47_RS01260 ENOG4105EN6 Membrane G3R47_RS01265 ENOG41079KZ Major Facilitator Superfamily G3R47_RS01270 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3R47_RS01275 ENOG4105CEY Amp-dependent synthetase and ligase G3R47_RS01290 ENOG4105F0N pyrophosphate phospho-hydrolase G3R47_RS01295 ENOG41090KI Outer membrane porin G3R47_RS01310 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G3R47_RS01315 ENOG4105FB2 class II Aldolase G3R47_RS01320 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3R47_RS01325 ENOG4105C0P Mg chelatase subunit ChlI G3R47_RS01375 ENOG4105GR3 Histidine kinase G3R47_RS01390 ENOG4105E3B Multicopper oxidase G3R47_RS01410 ENOG4105CE1 Ferrous iron transport protein b G3R47_RS01435 ENOG4105C0P Mg chelatase subunit ChlI G3R47_RS01450 ENOG4105BZU Histidine kinase G3R47_RS01460 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) G3R47_RS01500 ENOG4108K5H permease YjgP YjgQ family protein G3R47_RS01505 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G3R47_RS01510 ENOG4105CN1 protease G3R47_RS01515 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G3R47_RS01520 ENOG4107TUY Histidine kinase G3R47_RS01530 ENOG41061WM D-Alanyl-D-Alanine G3R47_RS01540 ENOG4105D6E homoserine dehydrogenase G3R47_RS01545 ENOG4105T95 Thiol disulfide interChange protein G3R47_RS01550 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G3R47_RS01560 ENOG4105CE1 Ferrous iron transport protein b G3R47_RS01575 ENOG4105CNI cell division protein FtsW G3R47_RS01580 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) G3R47_RS01590 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) G3R47_RS01620 ENOG4105DFG type I secretion outer membrane protein G3R47_RS01625 ENOG4108UTW Plays a role in the regulation of phosphate uptake G3R47_RS01640 ENOG4108HRK Histidine kinase G3R47_RS01645 ENOG4108NEV two component transcriptional regulator, LytTR family G3R47_RS01650 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) G3R47_RS01675 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS G3R47_RS01690 ENOG4105GVR general secretion pathway protein D G3R47_RS01695 ENOG4105TV9 FHA Domain-Containing protein G3R47_RS01700 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) G3R47_RS01740 ENOG4105PM1 preprotein translocase subunit SecE G3R47_RS01745 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) G3R47_RS01795 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) G3R47_RS01800 ENOG4105D3Y Na H antiporter G3R47_RS01815 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) G3R47_RS01830 ENOG4107ZXU DSBA oxidoreductase G3R47_RS01890 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase G3R47_RS01895 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G3R47_RS01925 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) G3R47_RS01935 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) G3R47_RS01950 ENOG4105C2N RNA methyltransferase TrmH family group 3 G3R47_RS01960 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) G3R47_RS01985 ENOG4107EJC Preprotein translocase subunit SecG G3R47_RS02010 ENOG4105CHV Transcription elongation factor NusA G3R47_RS02025 ENOG4105KJM monovalent cation h antiporter subunit g G3R47_RS02030 ENOG4105W4C monovalent cation H antiporter subunit F G3R47_RS02035 ENOG4105SC1 monovalent cation H antiporter subunit E G3R47_RS02040 ENOG4107R4Z monovalent cation h antiporter subunit d G3R47_RS02045 ENOG4108ZE9 Monovalent cation H antiporter subunit C G3R47_RS02050 ENOG4105D65 subunit l G3R47_RS02065 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase G3R47_RS02070 ENOG41061H0 Monooxygenase G3R47_RS02085 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G3R47_RS02095 ENOG4105CSR polyphosphate kinase 2 G3R47_RS02105 ENOG4105DSY exodeoxyribonuclease V, gamma G3R47_RS02110 ENOG4107QKA exodeoxyribonuclease V beta G3R47_RS02115 ENOG4107QYX exodeoxyribonuclease v alpha G3R47_RS02135 ENOG4107QUT magnesium and cobalt transport protein CorA G3R47_RS02140 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) G3R47_RS02145 ENOG4105DVC DnaJ domain protein G3R47_RS02160 ENOG4105CKD glutathione-regulated potassium-efflux system protein G3R47_RS02165 ENOG4105C25 Primosomal protein n' G3R47_RS02170 ENOG4105D7Q type ii secretion system G3R47_RS02175 ENOG4108VAU general secretion pathway protein G G3R47_RS02190 ENOG4108Z7R Chaperone CsaA G3R47_RS02195 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) G3R47_RS02200 ENOG4108JU5 Magnesium and cobalt efflux protein G3R47_RS02205 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) G3R47_RS02215 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase G3R47_RS02225 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) G3R47_RS02240 ENOG4105C5X domain protein G3R47_RS02245 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) G3R47_RS02255 ENOG4105BZ8 glutamate synthase G3R47_RS02290 ENOG4107T8P acyl-Coa dehydrogenase G3R47_RS02300 ENOG4107QI1 Mate efflux family protein G3R47_RS02310 ENOG4105CSA Coproporphyrinogen iii oxidase G3R47_RS02315 ENOG4105EMU Dehydrogenase G3R47_RS02320 ENOG4105CBN LysR family transcriptional regulator G3R47_RS02335 ENOG4105J5T Amp-dependent synthetase and ligase G3R47_RS02340 ENOG4105C03 ribonuclease G3R47_RS02345 ENOG4105EI2 Pseudouridine synthase G3R47_RS02350 ENOG4107XGZ Hydrolase G3R47_RS02355 ENOG4105D29 Helix-turn-helix type 11 domain protein G3R47_RS02370 ENOG4108W5M transcriptional regulator G3R47_RS02385 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase G3R47_RS02410 ENOG4105DUM transcriptional regulator, lysR family G3R47_RS02435 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G3R47_RS02490 ENOG4105CK2 sodium dicarboxylate symporter G3R47_RS02500 ENOG4105D1S lipid A biosynthesis G3R47_RS02505 ENOG4105N14 lysine exporter protein LysE YggA G3R47_RS02510 ENOG4105C5H ABC transporter G3R47_RS02525 ENOG4105KVH Transcriptional regulator G3R47_RS02535 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) G3R47_RS02550 ENOG4105C4R Atp-dependent dna helicase G3R47_RS02555 ENOG4105VFU Rna-binding protein G3R47_RS02575 ENOG4105CKD glutathione-regulated potassium-efflux system protein G3R47_RS02590 ENOG4107RGH Aldehyde dehydrogenase G3R47_RS02600 ENOG4105CIY formyltetrahydrofolate deformylase G3R47_RS02750 ENOG4105DWV Homoserine O-trans-acetylase G3R47_RS02760 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) G3R47_RS02770 ENOG4108ESX Receptor G3R47_RS02780 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G3R47_RS02800 ENOG4107GFK fumarate G3R47_RS02805 ENOG4108DNC Involved in acetate metabolism (By similarity) G3R47_RS02810 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) G3R47_RS02815 ENOG4105C01 Dihydroxy-acid dehydratase G3R47_RS02820 ENOG4108UHU Aldolase G3R47_RS02825 ENOG4105C6Z Gluconate G3R47_RS02830 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family G3R47_RS02835 ENOG4105C26 Dehydrogenase G3R47_RS02845 ENOG4106HB6 Alpha beta hydrolase G3R47_RS02860 ENOG4105CN1 protease G3R47_RS02875 ENOG4105WVQ Fe-S assembly protein IscX G3R47_RS02895 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) G3R47_RS02915 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) G3R47_RS02935 ENOG4105VW4 glutaredoxin 3 G3R47_RS02945 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) G3R47_RS02950 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) G3R47_RS02960 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH G3R47_RS02965 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G3R47_RS02970 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G3R47_RS02975 ENOG4105DJY efflux transporter, rnd family, mfp subunit G3R47_RS03000 ENOG4105C7K acetolactate synthase G3R47_RS03005 ENOG4108ZP8 Acetolactate synthase small subunit G3R47_RS03015 ENOG4105BZU Histidine kinase G3R47_RS03035 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) G3R47_RS03050 ENOG4105F8V Hydrolase, tatD family G3R47_RS03055 ENOG4107QM5 aconitate hydratase G3R47_RS03060 ENOG4105CUZ uba thif-type nad fad binding protein G3R47_RS03080 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) G3R47_RS03095 ENOG4106UX7 integral membrane protein G3R47_RS03100 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G3R47_RS03105 ENOG4105W8H transhydrogenase (subunit alpha G3R47_RS03110 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G3R47_RS03125 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) G3R47_RS03130 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3R47_RS03135 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase G3R47_RS03140 ENOG4105BZU Histidine kinase G3R47_RS03145 ENOG4105C6T cysteine synthase G3R47_RS03160 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G3R47_RS03170 ENOG4105DXN mazG family G3R47_RS03175 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein G3R47_RS03180 ENOG4105DJ0 Poly(A) Polymerase G3R47_RS03185 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase G3R47_RS03205 ENOG41080Z8 PHOSPHOCARRIER protein G3R47_RS03210 ENOG4105N42 UPF0307 protein G3R47_RS03215 ENOG4105CEY Amp-dependent synthetase and ligase G3R47_RS03230 ENOG4105CYM Glutathione S-transferase G3R47_RS03235 ENOG4105W39 Membrane G3R47_RS03275 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) G3R47_RS03295 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) G3R47_RS03305 ENOG4105C9X ppx gppa phosphatase G3R47_RS03315 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) G3R47_RS03320 ENOG4105II7 pyrroline-5-carboxylate reductase G3R47_RS03325 ENOG4108VIA integral membrane protein G3R47_RS03330 ENOG4105C2M dna polymerase I G3R47_RS03350 ENOG4107QHF type ii secretion system protein e G3R47_RS03355 ENOG4108ZHJ Organic hydroperoxide resistance protein G3R47_RS03360 ENOG4105K56 Transcriptional regulator G3R47_RS03430 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G3R47_RS03435 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) G3R47_RS03440 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) G3R47_RS03450 ENOG4105CRQ synthase (Component I) G3R47_RS03495 ENOG4108Z0R Transferase G3R47_RS03500 ENOG41072GX Peptidase M22 Glycoprotease G3R47_RS03515 ENOG4105C4W S-formylglutathione hydrolase G3R47_RS03525 ENOG4105DJV ribulose-phosphate 3-epimerase G3R47_RS03530 ENOG4108HCJ Hydrolase G3R47_RS03540 ENOG4105E3B Multicopper oxidase G3R47_RS03545 ENOG4105VR0 copper resistance G3R47_RS03560 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G3R47_RS03565 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) G3R47_RS03570 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) G3R47_RS03605 ENOG4105ETT transcriptional Regulator, LysR family G3R47_RS03610 ENOG4105C1G acyl-Coa dehydrogenase G3R47_RS03615 ENOG4107RGD Major Facilitator superfamily G3R47_RS03620 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3R47_RS03630 ENOG4107EFR Flavocytochrome c G3R47_RS03635 ENOG4106P55 Transcriptional regulator G3R47_RS03650 ENOG4106P55 Transcriptional regulator G3R47_RS03660 ENOG4105CH2 amidohydrolase G3R47_RS03680 ENOG4105ETT transcriptional Regulator, LysR family G3R47_RS03695 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) G3R47_RS03730 ENOG4105JAB phenazine biosynthesis protein, phzf family G3R47_RS03740 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G3R47_RS03750 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G3R47_RS03760 ENOG4107EXC regulatoR G3R47_RS03765 ENOG4105E0F Histidine kinase G3R47_RS03775 ENOG4105BZU Histidine kinase G3R47_RS03795 ENOG4105GKE subunit e G3R47_RS03800 ENOG4107QIZ NADH dehydrogenase G3R47_RS03805 ENOG4108IEH NADH dehydrogenase subunit g G3R47_RS03820 ENOG4107UFS subunit j G3R47_RS03830 ENOG4105D65 subunit l G3R47_RS03835 ENOG4105C8S subunit m G3R47_RS03855 ENOG4105DUM transcriptional regulator, lysR family G3R47_RS03860 ENOG4105DP0 ferredoxin-NADP reductase G3R47_RS03885 ENOG4105CBX hi0933 family G3R47_RS03890 ENOG4105K6H D-cysteine desulfhydrase G3R47_RS03920 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) G3R47_RS03930 ENOG4105D1F ATP-binding protein G3R47_RS03980 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) G3R47_RS03990 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY G3R47_RS04005 ENOG4105HF0 Membrane G3R47_RS04015 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) G3R47_RS04035 ENOG4106UW1 Major Facilitator superfamily G3R47_RS04040 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase G3R47_RS04045 ENOG4108K4C ec 3.1.3.12 G3R47_RS04050 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) G3R47_RS04060 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G3R47_RS04065 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) G3R47_RS04075 ENOG4105FE9 pseudouridine synthase G3R47_RS04080 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) G3R47_RS04085 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) G3R47_RS04090 ENOG4107RTD sua5 ycio yrdc ywlc family protein G3R47_RS04095 ENOG4108BPE -transporting atpase G3R47_RS04100 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein G3R47_RS04110 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase G3R47_RS04115 ENOG4105CHR reductase G3R47_RS04125 ENOG4109066 lysm domain bon superfamily protein G3R47_RS04130 ENOG4105DWF phosphomethylpyrimidine kinase G3R47_RS04140 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G3R47_RS04170 ENOG4105C5T Phosphoribosyl pyrophosphate synthase G3R47_RS04200 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) G3R47_RS04215 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) G3R47_RS04220 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane G3R47_RS04225 ENOG4105C34 Pseudouridine synthase G3R47_RS04230 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase G3R47_RS04265 ENOG41076J9 exonuclease VIII G3R47_RS04305 ENOG4108XTP Transcriptional regulator G3R47_RS04495 ENOG4105DFP Integrase G3R47_RS04505 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding G3R47_RS04525 ENOG4105EJC lysr family transcriptional regulator G3R47_RS04530 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G3R47_RS04535 ENOG4105C94 Transporter G3R47_RS04545 ENOG4105DVW rieske (2Fe-2S) G3R47_RS04550 ENOG4105C26 Dehydrogenase G3R47_RS04555 ENOG4105E3J oxidoreductase G3R47_RS04570 ENOG4105C4K Nad synthetase G3R47_RS04580 ENOG4105EUB pirin domain protein G3R47_RS04585 ENOG4108YXA Membrane G3R47_RS04630 ENOG4105KEG ribosomal-protein-alanine acetyltransferase G3R47_RS04640 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) G3R47_RS04645 ENOG4105C3M thioredoxin reductase G3R47_RS04650 ENOG4105CNU cell division protein FtsK G3R47_RS04655 ENOG4105CCF Lysine exporter protein (Lyse ygga) G3R47_RS04670 ENOG4107QMS site-determining protein G3R47_RS04685 ENOG4106HNH Acyl-transferase G3R47_RS04690 ENOG4108ZG0 Ompa motb domain protein G3R47_RS04695 ENOG4105C4R Atp-dependent dna helicase G3R47_RS04705 ENOG4107QKV phosphomannomutase G3R47_RS04720 ENOG4105E7A Glutamine amidotransferase G3R47_RS04745 ENOG41090R7 Ferric uptake G3R47_RS04750 ENOG4105CZX twitching motility protein G3R47_RS04755 ENOG4105CZX twitching motility protein G3R47_RS04760 ENOG4105DFA alanine racemase domain protein G3R47_RS04765 ENOG4105EYH Exonuclease G3R47_RS04770 ENOG4107RH8 nuclease SbcCD subunit D G3R47_RS04790 ENOG4105ECP epimerase G3R47_RS04795 ENOG4105MWK D-amino acid dehydrogenase, small subunit G3R47_RS04800 ENOG4105D52 delta-aminolevulinic acid dehydratase G3R47_RS04805 ENOG4108VUY thioesterase Superfamily protein G3R47_RS04810 ENOG4105CW7 secretion protein, HlyD family G3R47_RS04815 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3R47_RS04820 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G3R47_RS04830 ENOG4105DFP Integrase G3R47_RS04865 ENOG4105C54 Major Facilitator superfamily G3R47_RS04870 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G3R47_RS04880 ENOG4108SF5 RNA Polymerase G3R47_RS04910 ENOG4108YNN Heme oxygenase G3R47_RS04935 ENOG4105D5Q Arginine ornithine antiporter G3R47_RS04940 ENOG4107QK5 Homocysteine s-methyltransferase G3R47_RS04965 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) G3R47_RS04970 ENOG4105C94 Transporter G3R47_RS04975 ENOG4105C94 Transporter G3R47_RS04985 ENOG4108S4H thioesterase Superfamily protein G3R47_RS04995 ENOG4105CKI cobalamin synthesis protein G3R47_RS05005 ENOG4108VWS Yaeq family G3R47_RS05015 ENOG4107BJW polysaccharide deacetylase G3R47_RS05020 ENOG4105CND Glycosyl transferase, family 2 G3R47_RS05030 ENOG4106YT9 Enoyl-CoA hydratase G3R47_RS05045 ENOG41069M3 Transcriptional regulator G3R47_RS05080 ENOG4105DJB Major Facilitator Superfamily G3R47_RS05090 ENOG4108MXF Alpha Beta Hydrolase G3R47_RS05095 ENOG4105CHR reductase G3R47_RS05110 ENOG4105C7K acetolactate synthase G3R47_RS05120 ENOG4105CSH Transporter G3R47_RS05125 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G3R47_RS05130 ENOG4105CSV Glutaminase G3R47_RS05135 ENOG4108R6W Transcriptional regulator, ARAC family G3R47_RS05140 ENOG4105EU0 Major facilitator Superfamily G3R47_RS05145 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) G3R47_RS05160 ENOG4105C3R Methionine synthase G3R47_RS05165 ENOG4105CJ3 phosphate transporter G3R47_RS05185 ENOG4105E6M Sulphatase-modifying factor protein G3R47_RS05190 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) G3R47_RS05205 ENOG4107RNH Outer membrane receptor FepA G3R47_RS05225 ENOG4108UJV acyl-CoA thioesterase i G3R47_RS05230 ENOG4108I0Y (ABC) transporter G3R47_RS05235 ENOG4105CV6 ABC transporter, permease G3R47_RS05240 ENOG4107U91 Rhomboid family G3R47_RS05265 ENOG4105C5Q Transcriptional regulator G3R47_RS05275 ENOG4107QZF nitrite reductase NADPH large subunit G3R47_RS05280 ENOG4105VCQ rubredoxin G3R47_RS05300 ENOG4108MRJ G3R47_RS05315 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) G3R47_RS05330 ENOG4105D4T Citrate transporter G3R47_RS05335 ENOG4105C37 (CBS) domain G3R47_RS05345 ENOG4107RET Isocitrate lyase G3R47_RS05375 ENOG4105CQM Urea amidohydrolase subunit alpha G3R47_RS05385 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) G3R47_RS05400 ENOG4106H78 methyltransferase G3R47_RS05405 ENOG4105CJN penicillin-binding protein G3R47_RS05430 ENOG4105CSM endonuclease III G3R47_RS05435 ENOG4108R3D Electron transport complex G3R47_RS05440 ENOG4105D82 Glutamate dehydrogenase G3R47_RS05450 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b G3R47_RS05470 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase G3R47_RS05510 ENOG4107RAQ aminopeptidase G3R47_RS05515 ENOG4105D0A hydroxylase G3R47_RS05520 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family G3R47_RS05540 ENOG4108ZUB Lysine exporter protein (Lyse ygga) G3R47_RS05545 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) G3R47_RS05555 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) G3R47_RS05565 ENOG4105W4M Transport-associated protein G3R47_RS05575 ENOG4105E09 nadh pyrophosphatase G3R47_RS05585 ENOG4107RZZ dna polymerase iii epsilon subunit G3R47_RS05590 ENOG4105E9H Lytic Murein transglycosylase G3R47_RS05600 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component G3R47_RS05605 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component G3R47_RS05610 ENOG4108JQ5 ABC transporter G3R47_RS05630 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) G3R47_RS05660 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G3R47_RS05675 ENOG4108M3P Membrane G3R47_RS05680 ENOG4105D01 (LipO)protein G3R47_RS05695 ENOG4106B0W Curli production assembly transport component CsgG G3R47_RS05705 ENOG4107Y60 (LipO)protein G3R47_RS05715 ENOG4105C85 amino acid G3R47_RS05725 ENOG4105CUB amino acid G3R47_RS05745 ENOG4105C26 Dehydrogenase G3R47_RS05765 ENOG4105C85 amino acid G3R47_RS05770 ENOG4105D5K Hemolysin activator protein G3R47_RS05775 ENOG4105CKT filamentous hemagglutinin G3R47_RS05795 ENOG4107RGH Aldehyde dehydrogenase G3R47_RS05800 ENOG4108ZX5 transcriptional regulator G3R47_RS05805 ENOG4105DJP Membrane G3R47_RS05810 ENOG4105CTX dehydratase G3R47_RS05815 ENOG4105DJB Major Facilitator Superfamily G3R47_RS05820 ENOG4105EQX glucarate dehydratase G3R47_RS05830 ENOG4105CZJ Aldehyde dehydrogenase G3R47_RS05835 ENOG4105JXH GntR family transcriptional regulator G3R47_RS05850 ENOG4105NI3 Protein of unknown function (DUF3237) G3R47_RS05855 ENOG4105EPF Outer membrane porin G3R47_RS05860 ENOG4105C1G acyl-Coa dehydrogenase G3R47_RS05875 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase G3R47_RS05880 ENOG4108SC4 )-transporter G3R47_RS05895 ENOG4105E3J oxidoreductase G3R47_RS05910 ENOG4105E6M Sulphatase-modifying factor protein G3R47_RS05915 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) G3R47_RS05920 ENOG4105D2S major facilitator superfamily G3R47_RS05925 ENOG4105EPF Outer membrane porin G3R47_RS05945 ENOG4107RN6 Monooxygenase G3R47_RS05955 ENOG4105JQZ Methyltransferase G3R47_RS05960 ENOG4105F95 Monooxygenase G3R47_RS05995 ENOG4105F95 Monooxygenase G3R47_RS06005 ENOG4105C7N Xanthine uracil vitamin C permease G3R47_RS06010 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) G3R47_RS06015 ENOG4105CPW cytochrome b561 G3R47_RS06025 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G3R47_RS06035 ENOG4105CFH Aspartokinase G3R47_RS06340 ENOG4105DIJ Phosphoethanolamine transferase G3R47_RS06345 ENOG4105DFP Integrase G3R47_RS06355 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G3R47_RS06365 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis G3R47_RS06380 ENOG4105CPC Aldo Keto reductase G3R47_RS06385 ENOG4107RYR Transcriptional regulator, Crp Fnr family G3R47_RS06390 ENOG4108UKZ OsmC family G3R47_RS06405 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G3R47_RS06435 ENOG4105CD3 dihydroorotase G3R47_RS06440 ENOG4108ZG0 Ompa motb domain protein G3R47_RS06450 ENOG4108TGY Glutathione S-transferase G3R47_RS06455 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) G3R47_RS06465 ENOG4108K3A Glutathione S-transferase G3R47_RS06475 ENOG4108JU3 Alkyl hydroperoxide reductase G3R47_RS06485 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) G3R47_RS06495 ENOG4105D3R alkyl hydroperoxide reductase G3R47_RS06500 ENOG4105CQ7 ATP-dependent helicase G3R47_RS06515 ENOG4105D2S major facilitator superfamily G3R47_RS06520 ENOG4105DKK Benzoate G3R47_RS06525 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase G3R47_RS06530 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein G3R47_RS06535 ENOG4108UKV benzoate 1,2-dioxygenase G3R47_RS06540 ENOG4105FUY alpha subunit G3R47_RS06545 ENOG4108KB2 LysR family Transcriptional regulator G3R47_RS06595 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G3R47_RS06630 ENOG410829K Lysine exporter protein (Lyse ygga) G3R47_RS06635 ENOG4105VEQ Cold shock protein G3R47_RS06645 ENOG4105II7 pyrroline-5-carboxylate reductase G3R47_RS06715 ENOG4105C2X Arabinose 5-phosphate isomerase G3R47_RS06730 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA G3R47_RS06735 ENOG4108IUZ ABC transporter G3R47_RS06745 ENOG4105DFG type I secretion outer membrane protein G3R47_RS06785 ENOG4108Z4U Ferredoxin G3R47_RS06810 ENOG4105BZU Histidine kinase G3R47_RS06815 ENOG4105D1S lipid A biosynthesis G3R47_RS06825 ENOG4105D2S major facilitator superfamily G3R47_RS06845 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) G3R47_RS06875 ENOG4108WAV Transcriptional regulator G3R47_RS06880 ENOG4105C5A transporter G3R47_RS06900 ENOG4108JIK carboxylase G3R47_RS06905 ENOG4107R4J Chloride channel G3R47_RS06920 ENOG4105R8C Transcriptional regulator G3R47_RS06930 ENOG4105E2A Dehydrogenase G3R47_RS06945 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G3R47_RS06950 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF G3R47_RS06970 ENOG4105MRR Transcriptional regulator (By similarity) G3R47_RS06980 ENOG4108HW3 (ABC) transporter G3R47_RS07110 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G3R47_RS07140 ENOG4105EMY transcriptional regulator G3R47_RS07150 ENOG4107Y2X deaminase G3R47_RS07155 ENOG4105DJ2 Major Facilitator Superfamily G3R47_RS07180 ENOG4108Z4X TRANSCRIPTIONal G3R47_RS07190 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G3R47_RS07210 ENOG4105MWK D-amino acid dehydrogenase, small subunit G3R47_RS07235 ENOG4105CZJ Aldehyde dehydrogenase G3R47_RS07240 ENOG4107QTZ amino acid G3R47_RS07245 ENOG4105EJQ L-serine dehydratase G3R47_RS07250 ENOG4105DXM phenylacetic acid degradation protein G3R47_RS07255 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit G3R47_RS07260 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit G3R47_RS07265 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit G3R47_RS07270 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit G3R47_RS07275 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G3R47_RS07280 ENOG4105E39 Enoyl-CoA hydratase G3R47_RS07285 ENOG4108UKI Enoyl-CoA hydratase G3R47_RS07290 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3R47_RS07295 ENOG4105CHU acetyl-coa acetyltransferase G3R47_RS07300 ENOG4105DZS Phenylacetate-CoA ligase G3R47_RS07305 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein G3R47_RS07310 ENOG4108Z0R Transferase G3R47_RS07315 ENOG4107YAU phenylacetic acid degradation protein G3R47_RS07325 ENOG4108TGR phosphatase G3R47_RS07365 ENOG4105VEQ Cold shock protein G3R47_RS07380 ENOG4105CF7 AraC family transcriptional regulator G3R47_RS07395 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3R47_RS07400 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G3R47_RS07405 ENOG4105CSP Major Facilitator Superfamily G3R47_RS07410 ENOG4107VGR Catalase G3R47_RS07415 ENOG4105CPW cytochrome b561 G3R47_RS07420 ENOG4105HEI LysR family (Transcriptional regulator G3R47_RS07430 ENOG4107HP6 Transcriptional regulator G3R47_RS07435 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase G3R47_RS07450 ENOG4105C4Y ABC transporter G3R47_RS07455 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G3R47_RS07460 ENOG4107RCV ABC transporter, permease G3R47_RS07470 ENOG4107STF Involved in phosphonate degradation (By similarity) G3R47_RS07475 ENOG4108KAZ Involved in phosphonate degradation (By similarity) G3R47_RS07480 ENOG4107RGD Major Facilitator superfamily G3R47_RS07485 ENOG4105C1G acyl-Coa dehydrogenase G3R47_RS07500 ENOG4108UKI Enoyl-CoA hydratase G3R47_RS07505 ENOG4105EA8 2-Nitropropane dioxygenase G3R47_RS07510 ENOG4105EQ0 Major Facilitator superfamily G3R47_RS07520 ENOG4105CHU acetyl-coa acetyltransferase G3R47_RS07525 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3R47_RS07530 ENOG4108R85 Short chain dehydrogenase G3R47_RS07535 ENOG4105E39 Enoyl-CoA hydratase G3R47_RS07540 ENOG4105C1G acyl-Coa dehydrogenase G3R47_RS07545 ENOG4107RGD Major Facilitator superfamily G3R47_RS07550 ENOG4107QP7 CoA-transferase subunit A G3R47_RS07555 ENOG4107QNJ CoA-transferase subunit B G3R47_RS07575 ENOG4105CSU acyl-Coa dehydrogenase G3R47_RS07590 ENOG4105CC0 LysR family Transcriptional regulator G3R47_RS07605 ENOG4105E39 Enoyl-CoA hydratase G3R47_RS07610 ENOG4107QX3 carboxylase G3R47_RS07615 ENOG4105C1G acyl-Coa dehydrogenase G3R47_RS07620 ENOG4105R8C Transcriptional regulator G3R47_RS07625 ENOG4105CEY Amp-dependent synthetase and ligase G3R47_RS07645 ENOG4105HEI LysR family (Transcriptional regulator G3R47_RS07695 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G3R47_RS07715 ENOG4105KT5 UmuD protein G3R47_RS07725 ENOG4105EW9 transcriptional regulator AsnC family G3R47_RS07735 ENOG4105BZU Histidine kinase G3R47_RS07740 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase G3R47_RS07755 ENOG4105EAD ABC transporter G3R47_RS07760 ENOG4108HW4 amino acid AbC transporter G3R47_RS07765 ENOG4105CDA abc transporter atp-binding protein G3R47_RS07770 ENOG4107RP9 extracellular solute-binding protein, family 3 G3R47_RS07775 ENOG4105CT1 (ABC) transporter G3R47_RS07780 ENOG4105EXG Transcriptional regulator G3R47_RS07785 ENOG4105CCF Lysine exporter protein (Lyse ygga) G3R47_RS07790 ENOG4105C9B Cysteine desulfurase G3R47_RS07795 ENOG4105ESN nucleotide-binding protein G3R47_RS07800 ENOG4105D7W serine acetyltransferase G3R47_RS07810 ENOG4105CHR reductase G3R47_RS07815 ENOG4105CBN LysR family transcriptional regulator G3R47_RS07820 ENOG4105CYM Glutathione S-transferase G3R47_RS07825 ENOG4108SHQ Glutathione S-transferase G3R47_RS07830 ENOG4105CMU LysR family (Transcriptional regulator G3R47_RS07835 ENOG4105VAW lrga family G3R47_RS07840 ENOG41067MG lrgb family G3R47_RS07845 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3R47_RS07860 ENOG4105DXI Major Facilitator superfamily G3R47_RS07870 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase G3R47_RS07875 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) G3R47_RS07890 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase G3R47_RS07895 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase G3R47_RS07910 ENOG4108K70 Transcriptional regulator G3R47_RS07915 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3R47_RS07925 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G3R47_RS07930 ENOG4105C4M (Ubiquinol oxidase) subunit I G3R47_RS07950 ENOG4105C54 Major Facilitator superfamily G3R47_RS07960 ENOG4106FTQ Taurine ABC transporter, periplasmic G3R47_RS07965 ENOG4108IY8 ABC, transporter G3R47_RS07970 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3R47_RS07985 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease G3R47_RS07995 ENOG4105CBN LysR family transcriptional regulator G3R47_RS08005 ENOG4105CPN adenine deaminase G3R47_RS08020 ENOG41082YX Transcriptional regulator, arsr family G3R47_RS08025 ENOG4105D6J arsenicaL-resistance protein G3R47_RS08030 ENOG4108KB2 LysR family Transcriptional regulator G3R47_RS08045 ENOG4108JU3 Alkyl hydroperoxide reductase G3R47_RS08070 ENOG4105C0B DNA polymerase III (alpha subunit) G3R47_RS08085 ENOG4105CHM Aminotransferase G3R47_RS08095 ENOG4108V06 Glutathione peroxidase G3R47_RS08100 ENOG4105E7U AraC family transcriptional regulator G3R47_RS08130 ENOG4105ZED uncharacterized protein ygaH G3R47_RS08135 ENOG4108UMN azlc family G3R47_RS08160 ENOG4105C3G gtp-binding protein G3R47_RS08165 ENOG4108UMI ABC transporter, permease G3R47_RS08170 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) G3R47_RS08175 ENOG4105D01 (LipO)protein G3R47_RS08180 ENOG4105D01 (LipO)protein G3R47_RS08195 ENOG4107T8P acyl-Coa dehydrogenase G3R47_RS08210 ENOG4105EAD ABC transporter G3R47_RS08215 ENOG4105DRP amino acid AbC transporter G3R47_RS08220 ENOG4105CDA abc transporter atp-binding protein G3R47_RS08230 ENOG4105EW9 transcriptional regulator AsnC family G3R47_RS08245 ENOG41067SE Tetr family transcriptional regulator G3R47_RS08285 ENOG4105D5G Transposase G3R47_RS08305 ENOG4105CC0 LysR family Transcriptional regulator G3R47_RS08315 ENOG4105ETS cytosine purines uracil thiamine allantoin G3R47_RS08325 ENOG4108IPJ Membrane G3R47_RS08350 ENOG4105GQR Chaperone G3R47_RS08355 ENOG4105X0I Fimbrial G3R47_RS08375 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) G3R47_RS08380 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) G3R47_RS08400 ENOG4108HWY Beta-lactamase G3R47_RS08425 ENOG4105CV1 Transketolase (EC 2.2.1.1) G3R47_RS08435 ENOG4108YYC ycei family G3R47_RS08445 ENOG4108T58 Mg2 transport protein CorA G3R47_RS08460 ENOG4105YGK Pfam:UPF0157 G3R47_RS08465 ENOG4105C26 Dehydrogenase G3R47_RS08470 ENOG4105EW9 transcriptional regulator AsnC family G3R47_RS08475 ENOG4105CK7 Sodium proline symporter G3R47_RS08480 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) G3R47_RS08490 ENOG4108ZX5 transcriptional regulator G3R47_RS08500 ENOG4105BZ1 (ABC) transporter G3R47_RS08505 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme G3R47_RS08510 ENOG4105XPP Protein of unknown function (DUF1275) G3R47_RS08520 ENOG41080HT Transcriptional regulator, arsr family G3R47_RS08530 ENOG4105EZE Cupin 4 family protein G3R47_RS08535 ENOG4108UHJ MAF-like protein G3R47_RS08555 ENOG4105D2N Aldolase G3R47_RS08560 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) G3R47_RS08565 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) G3R47_RS08570 ENOG4105EHM Aminoglycoside phosphotransferase G3R47_RS08575 ENOG4108S0S Nucleotidyl transferase G3R47_RS08585 ENOG4107QJE Chromosome Partitioning Protein G3R47_RS08590 ENOG4105FA0 parb-like partition protein G3R47_RS08605 ENOG4105BZ1 (ABC) transporter G3R47_RS08610 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) G3R47_RS08620 ENOG4107QRG dna polymerase iii G3R47_RS08630 ENOG4105F8V Hydrolase, tatD family G3R47_RS08655 ENOG4108RTD type II secretion system protein K G3R47_RS08675 ENOG4108Z6B deaminase G3R47_RS08690 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) G3R47_RS08695 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) G3R47_RS08715 ENOG4107RN6 Monooxygenase G3R47_RS08725 ENOG4105D6Z AFG1 family ATPase G3R47_RS08730 ENOG4107QP3 malate synthase g G3R47_RS08740 ENOG4105SG9 biopolymer transport protein, ExbD G3R47_RS08770 ENOG4105DIB Oligopeptide-binding protein G3R47_RS08780 ENOG4105DGW oligopeptidase A G3R47_RS08790 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G3R47_RS08810 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase G3R47_RS08825 ENOG4105K4T epimerase G3R47_RS08830 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) G3R47_RS08850 ENOG4108JA2 transcriptioN-repair coupling factor G3R47_RS08860 ENOG4105F8J Adenylate Guanylate cyclase G3R47_RS08865 ENOG4108ZIT Ferredoxin, 2FE-2S G3R47_RS08880 ENOG4108Z4V iron-sulfur cluster assembly G3R47_RS08885 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins G3R47_RS08895 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family G3R47_RS08910 ENOG4105K70 DNA-binding protein G3R47_RS08915 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) G3R47_RS08920 ENOG4105E7U AraC family transcriptional regulator G3R47_RS08925 ENOG4105EEF Alkane 1-monooxygenase G3R47_RS08930 ENOG4105C1G acyl-Coa dehydrogenase G3R47_RS08935 ENOG4105C1G acyl-Coa dehydrogenase G3R47_RS08950 ENOG4108Z66 YbaK ebsC protein G3R47_RS08965 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3R47_RS08970 ENOG4105DUU IucA IucC family protein G3R47_RS08975 ENOG4105DJU Siderophore biosynthesis protein G3R47_RS08985 ENOG4105JSC dimethylmenaquinone methyltransferase G3R47_RS09025 ENOG4108YZT Adenosylcobinamide kinase G3R47_RS09030 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) G3R47_RS09035 ENOG4107TB6 phosphoglycerate mutase G3R47_RS09050 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G3R47_RS09055 ENOG4107TSN permease G3R47_RS09075 ENOG4105CNM Receptor G3R47_RS09080 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G3R47_RS09095 ENOG4105CJ1 ABC, transporter G3R47_RS09100 ENOG4107QWP ABC-2 type transporter G3R47_RS09105 ENOG4107QWP ABC-2 type transporter G3R47_RS09130 ENOG4105K59 histidine triad (HIT) protein G3R47_RS09160 ENOG4105F2W methyltransferase G3R47_RS09170 ENOG4105C28 cystathionine G3R47_RS09185 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) G3R47_RS09230 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) G3R47_RS09235 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) G3R47_RS09245 ENOG4105BZU Histidine kinase G3R47_RS09260 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) G3R47_RS09265 ENOG4107R0V Pyruvate dehydrogenase G3R47_RS09270 ENOG4105CPP Dehydrogenase, E1 component G3R47_RS09285 ENOG4105CHR reductase G3R47_RS09295 ENOG4105FFC UPF0187 protein G3R47_RS09305 ENOG4107S76 domain protein G3R47_RS09315 ENOG4108VCT Sulfite exporter TauE/SafE G3R47_RS09330 ENOG4105UEI Transcriptional Regulator AraC Family G3R47_RS09335 ENOG4105KVH Transcriptional regulator G3R47_RS09340 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) G3R47_RS09365 ENOG4106FTQ Taurine ABC transporter, periplasmic G3R47_RS09370 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G3R47_RS09390 ENOG4105CSH Transporter G3R47_RS09400 ENOG4108IJ0 Aspartate ammonia-lyase G3R47_RS09415 ENOG4107YNJ LysR family Transcriptional regulator G3R47_RS09425 ENOG4105CHU acetyl-coa acetyltransferase G3R47_RS09430 ENOG4105CRW Short chain fatty acid transporter G3R47_RS09445 ENOG4108M0I Transcriptional regulator G3R47_RS09455 ENOG4105CY2 Citrate transporter G3R47_RS09460 ENOG4105DTD Dehydrogenase G3R47_RS09465 ENOG4105CF7 AraC family transcriptional regulator G3R47_RS09470 ENOG4105D2S major facilitator superfamily G3R47_RS09480 ENOG4105CHR reductase G3R47_RS09505 ENOG4105F57 Anthranilate dioxygenase reductase G3R47_RS09510 ENOG4108YS2 small subunit G3R47_RS09515 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit G3R47_RS09520 ENOG4105F4R Transcriptional regulator mode G3R47_RS09525 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein G3R47_RS09530 ENOG4105E0C molybdate abc transporter G3R47_RS09535 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) G3R47_RS09540 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase G3R47_RS09545 ENOG4105WQI isochorismatase G3R47_RS09555 ENOG4107T31 5'-nucleotidase G3R47_RS09590 ENOG4108IGT Dipeptidase G3R47_RS09610 ENOG4107RZC phospholipase d G3R47_RS09760 ENOG4105X0I Fimbrial G3R47_RS09865 ENOG4105C5T Phosphoribosyl pyrophosphate synthase G3R47_RS09885 ENOG4105E0A ABC, transporter G3R47_RS09890 ENOG4105EHG Permease protein G3R47_RS09900 ENOG4105DQ4 alcohol dehydrogenase G3R47_RS09905 ENOG4105CF7 AraC family transcriptional regulator G3R47_RS09910 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3R47_RS09920 ENOG4105EXW epimerase dehydratase G3R47_RS09925 ENOG4105DDW LysR family Transcriptional regulator G3R47_RS09940 ENOG4105CZJ Aldehyde dehydrogenase G3R47_RS09960 ENOG4106P55 Transcriptional regulator G3R47_RS10020 ENOG4105CEY Amp-dependent synthetase and ligase G3R47_RS10030 ENOG4105CSU acyl-Coa dehydrogenase G3R47_RS10040 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G3R47_RS10045 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G3R47_RS10050 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G3R47_RS10055 ENOG4108PTX LysR family Transcriptional regulator G3R47_RS10060 ENOG4107Z3H Transcriptional regulator, TetR family G3R47_RS10115 ENOG4105CZJ Aldehyde dehydrogenase G3R47_RS10135 ENOG4107EJG GntR family transcriptional regulator G3R47_RS10145 ENOG4108KB2 LysR family Transcriptional regulator G3R47_RS10150 ENOG4105DTQ mandelate racemase muconate lactonizing G3R47_RS10155 ENOG4105NN7 muconolactone delta-isomerase G3R47_RS10165 ENOG4107QP7 CoA-transferase subunit A G3R47_RS10170 ENOG4107QNJ CoA-transferase subunit B G3R47_RS10175 ENOG4105CHU acetyl-coa acetyltransferase G3R47_RS10180 ENOG4105F2Z 3-oxoadipate enol-lactonase G3R47_RS10190 ENOG4105C26 Dehydrogenase G3R47_RS10200 ENOG4105F11 amine oxidase G3R47_RS10220 ENOG4105CHR reductase G3R47_RS10230 ENOG4105FUY alpha subunit G3R47_RS10250 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G3R47_RS10260 ENOG4105DNH Major Facilitator G3R47_RS10285 ENOG4105C1G acyl-Coa dehydrogenase G3R47_RS10290 ENOG4108PTX LysR family Transcriptional regulator G3R47_RS10295 ENOG4107HP6 Transcriptional regulator G3R47_RS10310 ENOG4105MD1 YeeE YedE family protein G3R47_RS10320 ENOG4105DZG Dehydrogenase G3R47_RS10325 ENOG4105TW1 Carbohydrate-selective porin OprB G3R47_RS10330 ENOG4106JPM 3-dehydroshikimate dehydratase G3R47_RS10335 ENOG4105FF2 Type I DHQase G3R47_RS10340 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha G3R47_RS10345 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta G3R47_RS10350 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase G3R47_RS10355 ENOG4105D2S major facilitator superfamily G3R47_RS10360 ENOG4105F2Z 3-oxoadipate enol-lactonase G3R47_RS10365 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase G3R47_RS10370 ENOG4105CHU acetyl-coa acetyltransferase G3R47_RS10375 ENOG4107QNJ CoA-transferase subunit B G3R47_RS10380 ENOG4107QP7 CoA-transferase subunit A G3R47_RS10390 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) G3R47_RS10395 ENOG4107VMU Membrane G3R47_RS10440 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G3R47_RS10455 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G3R47_RS10465 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G3R47_RS10470 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) G3R47_RS10500 ENOG4105C7B Threonine dehydratase G3R47_RS10510 ENOG4105CZN Potassium uptake protein G3R47_RS10515 ENOG4105HDD phospholipase G3R47_RS10525 ENOG4105E0K tonB-dependent siderophore receptor G3R47_RS10540 ENOG4105PV3 Inner membrane protein yqiJ G3R47_RS10550 ENOG4105C4M (Ubiquinol oxidase) subunit I G3R47_RS10555 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G3R47_RS10575 ENOG41068P6 UPF0319 protein G3R47_RS10585 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) G3R47_RS10610 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G3R47_RS10615 ENOG4105C8Y Acetylornithine aminotransferase G3R47_RS10620 ENOG4105M2J Glutaredoxin G3R47_RS10630 ENOG4105CC0 LysR family Transcriptional regulator G3R47_RS10635 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) G3R47_RS10640 ENOG4105CWM branched-chain amino acid transport system II carrier protein G3R47_RS10665 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) G3R47_RS10670 ENOG4105DE4 1-phosphofructokinase G3R47_RS10675 ENOG4105DM4 PTS System G3R47_RS10690 ENOG4105BZU Histidine kinase G3R47_RS10700 ENOG4105D8V Glucose sorbosone dehydrogenase G3R47_RS10705 ENOG4108RAV Conserved protein G3R47_RS10710 ENOG4105CHH sulfate transporter G3R47_RS10725 ENOG4105C85 amino acid G3R47_RS10735 ENOG4105F7P transcriptional regulator AsnC family G3R47_RS10760 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 G3R47_RS10765 ENOG4105VEJ Heat shock protein G3R47_RS10775 ENOG4105Y3E Modulates RecA activity (By similarity) G3R47_RS10790 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G3R47_RS10810 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane G3R47_RS10815 ENOG4105DZP Membrane-associated zinc metalloprotease G3R47_RS10825 ENOG4105KNE Phosphatidate cytidylyltransferase G3R47_RS10830 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) G3R47_RS10855 ENOG4105CUX Signal transduction histidine kinase G3R47_RS10860 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G3R47_RS10915 ENOG4105CMR udp-glucose 4-epimerase G3R47_RS10920 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) G3R47_RS10940 ENOG4105T38 integral membrane protein G3R47_RS10945 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3R47_RS10955 ENOG4105CVM Molybdenum cofactor synthesis domain protein G3R47_RS10960 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G3R47_RS10995 ENOG4108IFG nitrite reductase, (NAD(P)H) G3R47_RS11000 ENOG4107QZF nitrite reductase NADPH large subunit G3R47_RS11010 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3R47_RS11035 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein G3R47_RS11040 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G3R47_RS11050 ENOG4105D8G Major Facilitator superfamily G3R47_RS11055 ENOG4105VZ8 Transcriptional regulator G3R47_RS11115 ENOG4105DR5 peptidase G3R47_RS11375 ENOG4105CBC glutamate synthase G3R47_RS11415 ENOG4105C0A alcohol dehydrogenase G3R47_RS11425 ENOG4105HSS phospholipase C G3R47_RS11430 ENOG4107QMP dna polymerase iii subunits gamma and tau G3R47_RS11465 ENOG4105CHR reductase G3R47_RS11470 ENOG4105CHU acetyl-coa acetyltransferase G3R47_RS11480 ENOG4105CC0 LysR family Transcriptional regulator G3R47_RS11490 ENOG4108NIW Leucine export protein LeuE G3R47_RS11495 ENOG4105EW9 transcriptional regulator AsnC family G3R47_RS11500 ENOG4105DKK Benzoate G3R47_RS11545 ENOG41081QV Universal stress protein G3R47_RS11550 ENOG4105C5H ABC transporter G3R47_RS11570 ENOG4105CNM Receptor G3R47_RS11600 ENOG4105CUY Mechanosensitive ion channel G3R47_RS11610 ENOG4105R8C Transcriptional regulator G3R47_RS11620 ENOG4105EW9 transcriptional regulator AsnC family G3R47_RS11660 ENOG4105CD8 aminopeptidase N G3R47_RS11685 ENOG4107QUV Domain protein G3R47_RS11690 ENOG4105C0A alcohol dehydrogenase G3R47_RS11700 ENOG4107RR1 TRANSCRIPTIONal G3R47_RS11710 ENOG4107R55 ethanolamine transporter G3R47_RS11715 ENOG4105CPD ethanolamine ammonia-lyase G3R47_RS11720 ENOG4107FQ9 ethanolamine ammonia-lyase G3R47_RS11725 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G3R47_RS11730 ENOG4105CX6 glutaminyL-tRNA synthetase G3R47_RS11740 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) G3R47_RS11750 ENOG4108RCM Nitroreductase G3R47_RS11755 ENOG4108TZV Membrane G3R47_RS11760 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) G3R47_RS11770 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) G3R47_RS11775 ENOG4105K8N protein family UPF0079, ATPase G3R47_RS11810 ENOG4105DZ2 Transcriptional regulator G3R47_RS11830 ENOG4105F27 Major Facilitator G3R47_RS11835 ENOG4105EYW Ion transport protein G3R47_RS11845 ENOG4107QIJ Aconitate hydratase 2 G3R47_RS11860 ENOG4105CFU surface antigen G3R47_RS11865 ENOG4107S74 Lysophospholipid transporter LplT G3R47_RS11880 ENOG4105CFQ glutamine synthetase G3R47_RS11885 ENOG4105EEX Two component transcriptional regulator (Winged helix family G3R47_RS11890 ENOG4105C08 Histidine kinase G3R47_RS11895 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) G3R47_RS11900 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G3R47_RS11905 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G3R47_RS11925 ENOG4105D06 uba thif-type nad fad binding protein G3R47_RS11930 ENOG4108MEJ flavin reductase domain protein G3R47_RS11940 ENOG4105C1G acyl-Coa dehydrogenase G3R47_RS11955 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G3R47_RS11970 ENOG4105CC0 LysR family Transcriptional regulator G3R47_RS11985 ENOG4105DEN Luciferase family G3R47_RS12000 ENOG4105CND Glycosyl transferase, family 2 G3R47_RS12005 ENOG4107BJW polysaccharide deacetylase G3R47_RS12030 ENOG4105E2S oxidase) subunit II G3R47_RS12035 ENOG4105BZ9 Cytochrome C oxidase, subunit I G3R47_RS12040 ENOG4105CCU oxidase (Subunit III) G3R47_RS12045 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) G3R47_RS12070 ENOG4105CDU Replicative dna helicase G3R47_RS12075 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) G3R47_RS12125 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) G3R47_RS12130 ENOG4105DC1 bifunctional purine biosynthesis protein purh G3R47_RS12135 ENOG4105C12 Phosphoribosylglycinamide synthetase G3R47_RS12145 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) G3R47_RS12150 ENOG4108UMI ABC transporter, permease G3R47_RS12155 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G3R47_RS12165 ENOG4105CK2 sodium dicarboxylate symporter G3R47_RS12215 ENOG4105ETX regulatoR G3R47_RS12220 ENOG4105DHQ Histidine kinase G3R47_RS12225 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G3R47_RS12235 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G3R47_RS12275 ENOG4105VT2 5-hydroxyisourate hydrolase G3R47_RS12285 ENOG4105DY2 Paraquat-inducible protein b G3R47_RS12290 ENOG4105F1S paraquat-inducible protein a G3R47_RS12315 ENOG4105CSH Transporter G3R47_RS12365 ENOG4105JXH GntR family transcriptional regulator G3R47_RS12375 ENOG4105D6U Sodium Glutamate Symporter G3R47_RS12405 ENOG4105H4F exported protein G3R47_RS12440 ENOG4105C26 Dehydrogenase G3R47_RS12445 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G3R47_RS12450 ENOG4105EVZ LysR family transcriptional regulator G3R47_RS12475 ENOG4105D9P serine threonine protein kinase G3R47_RS12505 ENOG4105KTH gatB Yqey G3R47_RS12510 ENOG4105ERG peptidase m48, ste24p G3R47_RS12515 ENOG4105C5I Dehydrogenase G3R47_RS12530 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase G3R47_RS12565 ENOG41069NU Nitroreductase G3R47_RS12575 ENOG4105C1J atp-dependent rna helicase G3R47_RS12580 ENOG4105VEQ Cold shock protein G3R47_RS12590 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3R47_RS12595 ENOG4105M08 Membrane G3R47_RS12625 ENOG4105CYB regulatoR G3R47_RS12630 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) G3R47_RS12635 ENOG4105E0Y RtcB Protein G3R47_RS12655 ENOG4105CIN aminoacyl-histidine dipeptidase G3R47_RS12665 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase G3R47_RS12670 ENOG4105CQC Prephenate dehydratase G3R47_RS12685 ENOG4105CK2 sodium dicarboxylate symporter G3R47_RS12690 ENOG4107QYG anthranilate phosphoribosyltransferase G3R47_RS12695 ENOG4105VUT cytoplasmic protein G3R47_RS12700 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) G3R47_RS12705 ENOG4105BZ4 penicillin-binding protein G3R47_RS12715 ENOG4105M6F mutator MutT protein G3R47_RS12725 ENOG4105DHQ Histidine kinase G3R47_RS12730 ENOG4105XJC Two component transcriptional regulator (Winged helix family G3R47_RS12740 ENOG4107QHF type ii secretion system protein e G3R47_RS12750 ENOG4108R96 Methyltransferase, YaeB family G3R47_RS12755 ENOG4105DP0 ferredoxin-NADP reductase G3R47_RS12760 ENOG4105JAB phenazine biosynthesis protein, phzf family G3R47_RS12765 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3R47_RS12770 ENOG4105CFP Peptidase U32 G3R47_RS12775 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding G3R47_RS12785 ENOG4108JEH abc transporter atp-binding protein G3R47_RS12790 ENOG4106YG3 ABC transporter G3R47_RS12795 ENOG4105DSP amino acid AbC transporter G3R47_RS12800 ENOG4105E89 ABC transporter G3R47_RS12810 ENOG4105ENT Efflux transporter rnd family, mfp subunit G3R47_RS12820 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G3R47_RS12855 ENOG4105DA5 (ABC) transporter G3R47_RS12860 ENOG4105E3A (ABC) transporter G3R47_RS12875 ENOG4105CNI cell division protein FtsW G3R47_RS12880 ENOG4105CVE Lytic murein transglycosylase G3R47_RS12920 ENOG4105CE9 30S ribosomal protein S2 G3R47_RS12925 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) G3R47_RS12935 ENOG4107RNU major facilitator superfamily MFS_1 G3R47_RS12945 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) G3R47_RS12950 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) G3R47_RS12955 ENOG4107QPN acyl-Coa dehydrogenase G3R47_RS12970 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) G3R47_RS12975 ENOG4105SYT Methylenetetrahydrofolate reductase G3R47_RS12980 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) G3R47_RS12985 ENOG4105BZU Histidine kinase G3R47_RS12995 ENOG4105C6K Malic enzyme G3R47_RS13005 ENOG4105C0H protease G3R47_RS13010 ENOG4107QNR UPF0135 protein G3R47_RS13015 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G3R47_RS13055 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) G3R47_RS13070 ENOG4105DUX Transporter G3R47_RS13080 ENOG4105DDQ anthranilate synthase G3R47_RS13085 ENOG4105CD8 aminopeptidase N G3R47_RS13115 ENOG4105C7W Xanthine dehydrogenase G3R47_RS13125 ENOG4105EUJ GTP cyclohydrolase i G3R47_RS13145 ENOG4105NX3 Membrane G3R47_RS13160 ENOG4105E4F Isochorismate synthase G3R47_RS13175 ENOG4108JJ7 ABC transporter G3R47_RS13180 ENOG4105BZ1 (ABC) transporter G3R47_RS13195 ENOG4105WQI isochorismatase G3R47_RS13200 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G3R47_RS13205 ENOG4105C0W non-ribosomal peptide synthetase G3R47_RS13225 ENOG4108IPW abc transporter atp-binding protein G3R47_RS13240 ENOG4105CEY Amp-dependent synthetase and ligase G3R47_RS13255 ENOG4105WWK YheO domain protein G3R47_RS13265 ENOG4105C2I pirin domain protein G3R47_RS13300 ENOG4105VCD cytoplasmic protein G3R47_RS13305 ENOG4105D22 carbon starvation protein G3R47_RS13315 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein G3R47_RS13325 ENOG41066DG (EAL) domain protein G3R47_RS13335 ENOG4105DHU Bile acid G3R47_RS13350 ENOG4105DAN ATP-dependent protease G3R47_RS13355 ENOG4105EJC lysr family transcriptional regulator G3R47_RS13360 ENOG4108K5P (LipO)protein G3R47_RS13380 ENOG4105DZ1 carboxypeptidase G3R47_RS13385 ENOG4108Z0R Transferase G3R47_RS13405 ENOG4107QTF adenylosuccinate lyase G3R47_RS13420 ENOG4105ERU peptidase G3R47_RS13425 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G3R47_RS13435 ENOG4105C8U phosphate abc transporter G3R47_RS13440 ENOG4105CVA phosphate G3R47_RS13445 ENOG4105C85 amino acid G3R47_RS13450 ENOG4107RA9 decarboxylase G3R47_RS13455 ENOG4105F7P transcriptional regulator AsnC family G3R47_RS13465 ENOG4105DY8 decarboxylase G3R47_RS13470 ENOG4108JPW Aminotransferase G3R47_RS13495 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G3R47_RS13510 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) G3R47_RS13515 ENOG4105D3G Pseudouridine synthase G3R47_RS13530 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) G3R47_RS13560 ENOG4105JAB phenazine biosynthesis protein, phzf family G3R47_RS13565 ENOG4108ETY sodium dicarboxylate symporter G3R47_RS13570 ENOG4105EGI Transcriptional regulator G3R47_RS13575 ENOG4105CBP Major Facilitator G3R47_RS13600 ENOG4108R99 pseudouridine synthase G3R47_RS13605 ENOG4105E9K Isocitrate dehydrogenase G3R47_RS13615 ENOG4105DZ1 carboxypeptidase G3R47_RS13620 ENOG4105CEP NADH dehydrogenase G3R47_RS13625 ENOG4108YZY peptidylprolyl cis-trans isomerase G3R47_RS13630 ENOG4105CVP deoxyribo-dipyrimidine photolyase G3R47_RS13645 ENOG4107R8N Glycosyl transferase, family 2 G3R47_RS13675 ENOG4105EA8 2-Nitropropane dioxygenase G3R47_RS13680 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) G3R47_RS13685 ENOG4107QS8 (LipO)protein G3R47_RS13720 ENOG4105DTR rard protein G3R47_RS13730 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) G3R47_RS13740 ENOG4105BZU Histidine kinase G3R47_RS13760 ENOG4105F7F Chaperone G3R47_RS13790 ENOG4105EMU Dehydrogenase G3R47_RS13795 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase G3R47_RS13800 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) G3R47_RS13805 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) G3R47_RS13815 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) G3R47_RS13830 ENOG4105C3F Signal peptidase i G3R47_RS13845 ENOG4105C0H protease G3R47_RS13850 ENOG4108IYU L-aspartate oxidase G3R47_RS13865 ENOG4105HHA aminodeoxychorismate lyase G3R47_RS13870 ENOG4105YAZ 4-amino-4-deoxychorismate lyase G3R47_RS13875 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein G3R47_RS13885 ENOG4108I5D sulfate abc transporter G3R47_RS13895 ENOG4108IJ6 ABC transporter G3R47_RS13900 ENOG4107R11 Transcriptional regulator G3R47_RS13915 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) G3R47_RS13920 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) G3R47_RS13935 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G3R47_RS13950 ENOG4108UKI Enoyl-CoA hydratase G3R47_RS13960 ENOG4105C2C drug resistance transporter, Bcr CflA G3R47_RS13965 ENOG4108ETH Formylglycinamide ribotide synthetase G3R47_RS13985 ENOG4105CH2 amidohydrolase G3R47_RS13990 ENOG4107YD3 Thioesterase G3R47_RS13995 ENOG4105E02 MotA TolQ exbB proton channel G3R47_RS14000 ENOG4105M8F Biopolymer transport protein exbD tolR G3R47_RS14010 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) G3R47_RS14015 ENOG4105KCK Peptidoglycan-associated lipoprotein G3R47_RS14065 ENOG4105C02 permease G3R47_RS14075 ENOG4108V3E phosphoribosylglycinamide formyltransferase G3R47_RS14080 ENOG4107R6F Alpha Beta Hydrolase Fold protein G3R47_RS14085 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) G3R47_RS14095 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 G3R47_RS14100 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G3R47_RS14105 ENOG4105D60 lipoprotein releasing system transmembrane protein G3R47_RS14135 ENOG4107KET secretion protein, HlyD family G3R47_RS14170 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3R47_RS14175 ENOG4105C10 Electron transfer flavoprotein G3R47_RS14180 ENOG4105BZJ Electron transfer flavoprotein G3R47_RS14185 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G3R47_RS14190 ENOG4105N14 lysine exporter protein LysE YggA G3R47_RS14195 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) G3R47_RS14205 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) G3R47_RS14215 ENOG4105C85 amino acid G3R47_RS14220 ENOG4105BZG amino acid carrier protein G3R47_RS14225 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) G3R47_RS14235 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) G3R47_RS14250 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) G3R47_RS14255 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit G3R47_RS14260 ENOG4105BZW Glycerate kinase G3R47_RS14300 ENOG4105CEY Amp-dependent synthetase and ligase G3R47_RS14315 ENOG4108RRZ Transcription elongation factor GreB G3R47_RS14335 ENOG4105E4C Lytic transglycosylase catalytic G3R47_RS14350 ENOG4105BZS acriflavin resistance protein G3R47_RS14355 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase G3R47_RS14365 ENOG41080IJ Diacylglycerol kinase G3R47_RS14380 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) G3R47_RS14395 ENOG4105C6V Glycerol-3-phosphate dehydrogenase G3R47_RS14400 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G3R47_RS14405 ENOG4105CSH Transporter G3R47_RS14455 ENOG4105EEI dihydropteroate synthase G3R47_RS14460 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G3R47_RS14470 ENOG4105HBR Rna-binding protein G3R47_RS14485 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain G3R47_RS14490 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain G3R47_RS14500 ENOG4108IG5 Transcriptional regulator G3R47_RS14505 ENOG4108UQ8 endoribonuclease L-psp G3R47_RS14515 ENOG41080TK Universal stress protein G3R47_RS14530 ENOG4105PNM synthesis protein G3R47_RS14545 ENOG4105EEQ Na H antiporter G3R47_RS14550 ENOG4105CGZ zinc metallopeptidase G3R47_RS14555 ENOG4105CKW Inner membrane protein yedI G3R47_RS14565 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha G3R47_RS14575 ENOG4107QN2 dihydrolipoyl dehydrogenase G3R47_RS14580 ENOG4105C7S Dehydrogenase G3R47_RS14585 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 G3R47_RS14600 ENOG4105E33 succinate dehydrogenase G3R47_RS14610 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein G3R47_RS14615 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit G3R47_RS14645 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3R47_RS14650 ENOG41084BA UPF0250 protein G3R47_RS14655 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) G3R47_RS14670 ENOG4105CUB amino acid G3R47_RS14685 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) G3R47_RS14690 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G3R47_RS14705 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) G3R47_RS14730 ENOG410841Q phosphoesterase PA-phosphatase related protein G3R47_RS14735 ENOG4105C1P efflux transporter, rnd family, mfp subunit G3R47_RS14740 ENOG4105BZS acriflavin resistance protein G3R47_RS14745 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G3R47_RS14750 ENOG4105K8R UPF0145 protein G3R47_RS14755 ENOG4105K8R UPF0145 protein G3R47_RS14775 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) G3R47_RS14780 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) G3R47_RS14805 ENOG4108M0I Transcriptional regulator G3R47_RS14820 ENOG4105DHQ Histidine kinase G3R47_RS14825 ENOG4105XJC Two component transcriptional regulator (Winged helix family G3R47_RS14830 ENOG4105DIJ Phosphoethanolamine transferase G3R47_RS14850 ENOG4105D78 K07001 NTE family protein G3R47_RS14865 ENOG4105MSB protein, conserved in bacteria G3R47_RS14870 ENOG4105CTB Polyprenyl synthetase G3R47_RS14875 ENOG4105C7F AcnD-accessory protein PrpF G3R47_RS14880 ENOG4105C85 amino acid G3R47_RS14920 ENOG4105CF7 AraC family transcriptional regulator G3R47_RS14945 ENOG4108X0B nad(p)h dehydrogenase (quinone) G3R47_RS14955 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein G3R47_RS14965 ENOG4105D8T Acyltransferase G3R47_RS14975 ENOG4105C03 ribonuclease G3R47_RS14980 ENOG4108Z03 MAF-like protein G3R47_RS14985 ENOG4105VQ7 Rod shape-determining protein MreD G3R47_RS14990 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) G3R47_RS15000 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G3R47_RS15010 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G3R47_RS15035 ENOG4105C9K Endothelin-converting enzyme 1 G3R47_RS15045 ENOG4105C7B Threonine dehydratase G3R47_RS15050 ENOG4105D78 K07001 NTE family protein G3R47_RS15055 ENOG4105BZG amino acid carrier protein G3R47_RS15075 ENOG4105C2C drug resistance transporter, Bcr CflA G3R47_RS15080 ENOG4105EM2 membrane G3R47_RS15130 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein G3R47_RS15135 ENOG4105WD1 Membrane G3R47_RS15145 ENOG4107PEH Entericidin EcnA/B family G3R47_RS15160 ENOG4105CBS Chea signal transduction histidine kinase G3R47_RS15165 ENOG4105C8Q Methyl-accepting chemotaxis G3R47_RS15170 ENOG4108ZGA chew protein G3R47_RS15175 ENOG4105M3Z response regulator G3R47_RS15180 ENOG4108UNF response regulator G3R47_RS15205 ENOG4105KWI UPF0339 protein G3R47_RS15210 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA G3R47_RS15215 ENOG4105K78 MarR family Transcriptional regulator G3R47_RS15225 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) G3R47_RS15230 ENOG4105T95 Thiol disulfide interChange protein G3R47_RS15240 ENOG4108N2Y auxin Efflux G3R47_RS15245 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G3R47_RS15250 ENOG4105CHB tonB-dependent Receptor G3R47_RS15255 ENOG4108VX5 3-methyladenine DNA glycosylase G3R47_RS15265 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) G3R47_RS15280 ENOG4105CI3 gtp-binding protein typa G3R47_RS15285 ENOG4105C2W permease G3R47_RS15295 ENOG4108IQI permease G3R47_RS15300 ENOG4105E0Y RtcB Protein G3R47_RS15310 ENOG4108WHA ompa motb domain protein G3R47_RS15320 ENOG4105CHU acetyl-coa acetyltransferase G3R47_RS15340 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) G3R47_RS15345 ENOG4105DZG Dehydrogenase G3R47_RS15350 ENOG4105TW1 Carbohydrate-selective porin OprB G3R47_RS15360 ENOG4108R6W Transcriptional regulator, ARAC family G3R47_RS15365 ENOG4105CHU acetyl-coa acetyltransferase G3R47_RS15395 ENOG4108UT2 hemolysin iii G3R47_RS15400 ENOG4105CSH Transporter G3R47_RS15415 ENOG4105D3R alkyl hydroperoxide reductase G3R47_RS15435 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase G3R47_RS15480 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) G3R47_RS15485 ENOG4108WBT adenosyltransferase G3R47_RS15505 ENOG4105CNG UPF0061 protein G3R47_RS15510 ENOG4105E3W Two component transcriptional regulator (Winged helix family G3R47_RS15515 ENOG4105EB3 Histidine kinase G3R47_RS15525 ENOG4105CSU acyl-Coa dehydrogenase G3R47_RS15530 ENOG4105CSU acyl-Coa dehydrogenase G3R47_RS15535 ENOG4108VY7 phosphate-starvation-inducible protein PsiE G3R47_RS15555 ENOG4105UGU tonB-dependent Receptor G3R47_RS15580 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase G3R47_RS15595 ENOG4108PQP glycosyl transferase group 1 G3R47_RS15605 ENOG4107BJW polysaccharide deacetylase G3R47_RS15620 ENOG4105CM2 brancheD-chain amino acid aminotransferase G3R47_RS15625 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) G3R47_RS15630 ENOG4105BZU Histidine kinase G3R47_RS15665 ENOG4105VIE preprotein translocase, subunit YajC G3R47_RS15670 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G3R47_RS15675 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G3R47_RS15680 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase G3R47_RS15690 ENOG4105FFC UPF0187 protein G3R47_RS15695 ENOG4105DB7 PHP domain protein G3R47_RS15705 ENOG4105K9H YciI-like protein G3R47_RS15735 ENOG4105NAU thioesterase Superfamily protein G3R47_RS15745 ENOG4107U2T alpha beta G3R47_RS15760 ENOG4107QN2 dihydrolipoyl dehydrogenase G3R47_RS15800 ENOG4108KHX Diguanylate cyclase G3R47_RS15805 ENOG4105UYK outer membrane protein a G3R47_RS15815 ENOG4107RZC phospholipase d G3R47_RS15825 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) G3R47_RS15845 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) G3R47_RS15850 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) G3R47_RS15855 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) G3R47_RS15865 ENOG4108UJD 30S ribosomal protein S9 G3R47_RS15870 ENOG4107MKT Stringent starvation protein a G3R47_RS15875 ENOG4105KB2 stringent starvation protein b G3R47_RS15895 ENOG4105C1G acyl-Coa dehydrogenase G3R47_RS15900 ENOG4107QX3 carboxylase G3R47_RS15915 ENOG4108RZE Tetr family transcriptional regulator G3R47_RS15920 ENOG4105C1G acyl-Coa dehydrogenase G3R47_RS15970 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase G3R47_RS15975 ENOG4105D6S protein involved in catabolism of external DNA G3R47_RS16005 ENOG4105E4C Lytic transglycosylase catalytic G3R47_RS16015 ENOG4105C9A Phoh family G3R47_RS16045 ENOG4105CS1 NAD(P)H quinone oxidoreductase G3R47_RS16050 ENOG4107S2Z UPF0761 membrane protein G3R47_RS16060 ENOG4108K2B transcriptional regulator G3R47_RS16065 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase G3R47_RS16110 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) G3R47_RS16115 ENOG4105DGW oligopeptidase A G3R47_RS16120 ENOG4105VKU nucleicacid-binding protein G3R47_RS16155 ENOG4105C1G acyl-Coa dehydrogenase G3R47_RS16195 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) G3R47_RS16305 ENOG41089BK Glutamine amido-transferase G3R47_RS16315 ENOG4105D7A ATP-binding protein G3R47_RS16325 ENOG4105KPV Transcriptional regulator G3R47_RS16340 ENOG4105CK2 sodium dicarboxylate symporter G3R47_RS16345 ENOG4105C29 acyl-CoA thioesterase G3R47_RS16365 ENOG4105CB5 ATP-dependent DNA helicase recG G3R47_RS16370 ENOG4105MJ2 Competence protein G3R47_RS16380 ENOG4108URH decarboxylase G3R47_RS16385 ENOG4105D7N magnesium and cobalt transport protein CorA G3R47_RS16395 ENOG4105E3I toluene tolerance G3R47_RS16405 ENOG4105CY3 ABC transporter, permease G3R47_RS16410 ENOG4105DHJ ABC, transporter G3R47_RS16420 ENOG4105C1J atp-dependent rna helicase G3R47_RS16425 ENOG4105ECY inositol monophosphatase G3R47_RS16440 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) G3R47_RS16455 ENOG4105CSU acyl-Coa dehydrogenase G3R47_RS16465 ENOG41067S9 phage shock protein C, PspC G3R47_RS16470 ENOG4105W87 Cbs domain G3R47_RS16520 ENOG4105D5G Transposase G3R47_RS16570 ENOG4105C26 Dehydrogenase G3R47_RS16580 ENOG4105C8Y Acetylornithine aminotransferase G3R47_RS16585 ENOG4105D82 Glutamate dehydrogenase G3R47_RS16590 ENOG4108IQI permease G3R47_RS16620 ENOG4107SKI cobyrinic Acid a,c-diamide synthase G3R47_RS16625 ENOG4105IPI Membrane G3R47_RS16630 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G3R47_RS16635 ENOG4105EM2 membrane G3R47_RS16640 ENOG4107QF7 multi-drug G3R47_RS16650 ENOG4105NF4 modulator of drug activity G3R47_RS16655 ENOG4105VRH Antibiotic biosynthesis monooxygenase G3R47_RS16665 ENOG4105CQB FAD linked oxidase domain protein G3R47_RS16670 ENOG4108JQ1 Dehydrogenase G3R47_RS16695 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) G3R47_RS16700 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) G3R47_RS16705 ENOG4107IFA Lipase (EC 3.1.1.3) G3R47_RS16720 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) G3R47_RS16770 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) G3R47_RS16785 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G3R47_RS16790 ENOG4105KME endoribonuclease L-psp G3R47_RS16800 ENOG4108UQY Iron-storage protein G3R47_RS16805 ENOG4108YSG O-Antigen polymerase G3R47_RS16825 ENOG4105HA9 of methanol dehydrogenase type G3R47_RS16830 ENOG4108V0P LemA family G3R47_RS16840 ENOG4105BZ8 glutamate synthase G3R47_RS16845 ENOG4105CBC glutamate synthase G3R47_RS16865 ENOG4105E4G Type IV pilus G3R47_RS16890 ENOG4108JQC penicillin-binding protein 1A G3R47_RS16895 ENOG4105DHI Methyltransferase G3R47_RS16910 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) G3R47_RS16915 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) G3R47_RS16920 ENOG4105CJN penicillin-binding protein G3R47_RS16935 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein G3R47_RS16960 ENOG4108IQI permease G3R47_RS17025 ENOG4105C5H ABC transporter G3R47_RS17035 ENOG4105PDP Short chain dehydrogenase G3R47_RS17040 ENOG4105CHH sulfate transporter G3R47_RS17055 ENOG4105E0F Histidine kinase G3R47_RS17065 ENOG4105CYC Transferase G3R47_RS17070 ENOG4108R6G acetyltransferase G3R47_RS17095 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) G3R47_RS17115 ENOG4105BZ1 (ABC) transporter G3R47_RS17130 ENOG41061CK Antibiotic biosynthesis monooxygenase G3R47_RS17145 ENOG4105CUV Homoserine Kinase G3R47_RS17200 ENOG4108UQN AraC family transcriptional regulator G3R47_RS17205 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain G3R47_RS17220 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein G3R47_RS17225 ENOG4105KVH Transcriptional regulator G3R47_RS17235 ENOG4105C2J ABC transporter G3R47_RS17250 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) G3R47_RS17255 ENOG4105CPC Aldo Keto reductase G3R47_RS17305 ENOG4106NZI LysR family Transcriptional regulator G3R47_RS17310 ENOG4105D94 Major Facilitator Superfamily G3R47_RS17400 ENOG4105D5G Transposase G3R47_RS17430 ENOG4105EUB pirin domain protein G3R47_RS17435 ENOG4105CHJ isochorismatase hydrolase G3R47_RS17445 ENOG4105C26 Dehydrogenase G3R47_RS17450 ENOG4108JPW Aminotransferase G3R47_RS17460 ENOG4105C85 amino acid G3R47_RS17470 ENOG4108UMN azlc family G3R47_RS17480 ENOG4108UUM single-stranded DNA-binding protein G3R47_RS17485 ENOG4107RDB Major Facilitator G3R47_RS17495 ENOG4105DWF phosphomethylpyrimidine kinase G3R47_RS17500 ENOG4105RA2 Membrane G3R47_RS17510 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G3R47_RS17515 ENOG4108WUH Transcriptional regulator, TetR family G3R47_RS17520 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) G3R47_RS17525 ENOG4105BZU Histidine kinase G3R47_RS17535 ENOG4105C94 Transporter G3R47_RS17545 ENOG4107QN1 sodium solute G3R47_RS17550 ENOG41062QD Membrane G3R47_RS17555 ENOG4105BZU Histidine kinase G3R47_RS17570 ENOG4108UZX fmn reductase G3R47_RS17575 ENOG4105FBW Monooxygenase G3R47_RS17585 ENOG4108W2Y isochorismatase G3R47_RS17590 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G3R47_RS17600 ENOG4105D64 Mechanosensitive ion channel G3R47_RS17610 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase G3R47_RS17615 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G3R47_RS17635 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) G3R47_RS17650 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G3R47_RS17665 ENOG4105E0K tonB-dependent siderophore receptor G3R47_RS17680 ENOG4107QSN dihydrolipoamide acetyltransferase G3R47_RS17685 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) G3R47_RS17690 ENOG41063SB peptidase G3R47_RS17705 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) G3R47_RS17710 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) G3R47_RS17715 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) G3R47_RS17735 ENOG4105D7Z glutathione synthase G3R47_RS17760 ENOG4105CGK Exodeoxyribonuclease III G3R47_RS17765 ENOG4105KUZ arsenate reductase G3R47_RS17780 ENOG4105BZU Histidine kinase G3R47_RS17785 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) G3R47_RS17815 ENOG41084YZ Hydrolase G3R47_RS17830 ENOG41061H0 Monooxygenase G3R47_RS17840 ENOG4108Z2U ureidoglycolate hydrolase G3R47_RS17845 ENOG4105EWI Short-chain dehydrogenase reductase Sdr G3R47_RS17850 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3R47_RS17855 ENOG4105IPS esterase G3R47_RS17915 ENOG4105CS6 Rhs element vgr protein G3R47_RS17925 ENOG4105D9M gamma-glutamylcysteine synthetase G3R47_RS17940 ENOG4106BRA Membrane G3R47_RS17945 ENOG4105CHM Aminotransferase G3R47_RS17950 ENOG4107QJQ Mate efflux family protein G3R47_RS17965 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3R47_RS17970 ENOG4105BZU Histidine kinase G3R47_RS17985 ENOG4105KHC sulfurtransferase G3R47_RS18020 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G3R47_RS18035 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) G3R47_RS18040 ENOG4108ZAI phosphatidylglycerophosphatase a G3R47_RS18050 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) G3R47_RS18055 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) G3R47_RS18070 ENOG41088SP formiminoglutamate hydrolase G3R47_RS18080 ENOG4105C85 amino acid G3R47_RS18095 ENOG41090B9 response to stress G3R47_RS18100 ENOG4105CZE histidine utilization repressor G3R47_RS18110 ENOG4105CKI cobalamin synthesis protein G3R47_RS18120 ENOG4105C85 amino acid G3R47_RS18130 ENOG4108RXX maleylacetoacetate isomerase G3R47_RS18150 ENOG4105EWC Purine nucleoside phosphorylase G3R47_RS18155 ENOG4107QI1 Mate efflux family protein G3R47_RS18160 ENOG4105C09 Bile acid G3R47_RS18165 ENOG4108RWI nicotinamidase G3R47_RS18170 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G3R47_RS18190 ENOG4105S64 Formate nitrite transporter G3R47_RS18195 ENOG4105D1H recombination factor protein RarA G3R47_RS18205 ENOG4108ZZ3 UPF0260 protein G3R47_RS18225 ENOG4105CEN a g-specific adenine glycosylase G3R47_RS18240 ENOG4108R3E Dna-3-methyladenine glycosylase i G3R47_RS18265 ENOG4105HEI LysR family (Transcriptional regulator G3R47_RS18270 ENOG4105CV8 reductase G3R47_RS18275 ENOG4105F27 Major Facilitator G3R47_RS18310 ENOG4105DJY efflux transporter, rnd family, mfp subunit G3R47_RS18315 ENOG4108IG5 Transcriptional regulator G3R47_RS18325 ENOG4105C2W permease G3R47_RS18330 ENOG4108W5M transcriptional regulator G3R47_RS18355 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B G3R47_RS18365 ENOG4105C8J )-transporter G3R47_RS18410 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) G3R47_RS18465 ENOG4105CVE Lytic murein transglycosylase G3R47_RS18470 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit G3R47_RS18475 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) G3R47_RS18485 ENOG4105DFU Cell wall formation (By similarity) G3R47_RS18495 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase G3R47_RS18500 ENOG4105DU1 integral membrane protein, terc G3R47_RS18510 ENOG4106032 Glutathionylspermidine synthase G3R47_RS18520 ENOG4107QUY Guanine deaminase G3R47_RS18525 ENOG4108UGV hypoxanthine phosphoribosyltransferase G3R47_RS18535 ENOG4105T95 Thiol disulfide interChange protein G3R47_RS18540 ENOG4105PGM cation diffusion facilitator family transporter G3R47_RS18555 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins G3R47_RS18575 ENOG4107QHF type ii secretion system protein e G3R47_RS18590 ENOG4105FA0 parb-like partition protein G3R47_RS18595 ENOG4107QJE Chromosome Partitioning Protein G3R47_RS18685 ENOG4105EKQ RNA-directed DNA polymerase G3R47_RS18695 ENOG4105MP0 transposase G3R47_RS18715 ENOG4105EKQ RNA-directed DNA polymerase G3R47_RS18860 ENOG4105ERG peptidase m48, ste24p G3R47_RS18935 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) G3R47_RS18965 ENOG4108BUD transposase G3R47_RS18980 ENOG4105C1P efflux transporter, rnd family, mfp subunit G3R47_RS18985 ENOG4105BZS acriflavin resistance protein G3R47_RS18995 ENOG4105BZU Histidine kinase G3R47_RS19000 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3R47_RS19010 ENOG4108HWY Beta-lactamase G3R47_RS19050 ENOG4105I1F Resistance protein G3R47_RS19075 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G3R47_RS19205 ENOG4107QMH DNA methylase G3R47_RS19215 ENOG4105KK6 nuclease G3R47_RS19265 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) G3R47_RS19440 ENOG4105F9F transposase G3R47_RS19460 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) G3R47_RS19465 ENOG4105VF7 tolerance protein G3R47_RS19470 ENOG4105EPC oxidoreductase G3R47_RS19475 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase G3R47_RS19490 ENOG4105F9F transposase G3R47_RS19525 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G3R47_RS19530 ENOG4105KT5 UmuD protein G3R47_RS19605 ENOG4105DND Transcriptional regulator G3R47_RS19620 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) G3R47_RS19705 ENOG4105EMU Dehydrogenase