locus-tag	class	description
C2U32_RS00005	COG1981	membrane
C2U32_RS00050	COG0456	acetyltransferase
C2U32_RS00060	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C2U32_RS00065	COG0492	ferredoxin-NADP+ reductase activity
C2U32_RS00070	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2U32_RS00070	COG1674	ftsk spoiiie
C2U32_RS00075	COG1280	lysine exporter protein (LysE YggA)
C2U32_RS00090	COG2894	cell division
C2U32_RS00105	COG0204	Acyl-transferase
C2U32_RS00110	COG2885	chlorophyll binding
C2U32_RS00115	COG0210	DNA helicase
C2U32_RS00125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2U32_RS00140	COG0121	glutamine amidotransferase
C2U32_RS00165	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U32_RS00170	COG0735	belongs to the Fur family
C2U32_RS00195	COG0420	3'-5' exonuclease activity
C2U32_RS00215	COG1090	epimerase
C2U32_RS00230	COG2050	protein possibly involved in aromatic compounds catabolism
C2U32_RS00240	COG2814	Major facilitator Superfamily
C2U32_RS00245	COG0405	Gamma-glutamyltransferase
C2U32_RS00295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U32_RS00385	COG1484	DNA-dependent DNA replication
C2U32_RS00460	COG3755	Protein conserved in bacteria
C2U32_RS00610	COG2026	Addiction module toxin, RelE StbE family
C2U32_RS00650	COG0592	DNA-directed DNA polymerase activity
C2U32_RS00720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U32_RS00745	COG3328	transposase activity
C2U32_RS00810	COG3293	Transposase
C2U32_RS00850	COG3293	Transposase
C2U32_RS00870	COG0477	Major facilitator Superfamily
C2U32_RS00875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U32_RS00900	COG0531	amino acid
C2U32_RS00905	COG2040	homocysteine
C2U32_RS00930	COG1309	transcriptional regulator
C2U32_RS00935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2U32_RS00940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2U32_RS00950	COG1607	acyl-coa hydrolase
C2U32_RS00960	COG0523	cobalamin synthesis protein
C2U32_RS00970	COG4681	YaeQ
C2U32_RS00980	COG1649	PFAM Uncharacterised BCR, COG1649
C2U32_RS00980	COG0726	polysaccharide deacetylase
C2U32_RS00985	COG1215	transferase activity, transferring glycosyl groups
C2U32_RS00995	COG1024	Enoyl-CoA hydratase
C2U32_RS01010	COG1414	Transcriptional regulator
C2U32_RS01030	COG1028	Short-chain dehydrogenase reductase Sdr
C2U32_RS01040	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U32_RS01045	COG2271	Major facilitator Superfamily
C2U32_RS01055	COG2267	carboxylic ester hydrolase activity
C2U32_RS01060	COG1028	Short-chain dehydrogenase reductase Sdr
C2U32_RS01075	COG0028	Belongs to the TPP enzyme family
C2U32_RS01085	COG0477	Major facilitator Superfamily
C2U32_RS01090	COG0242	peptide deformylase activity
C2U32_RS01095	COG2066	Belongs to the glutaminase family
C2U32_RS01100	COG2207	Transcriptional regulator
C2U32_RS01105	COG2223	nitrite transmembrane transporter activity
C2U32_RS01125	COG0583	DNA-binding transcription factor activity
C2U32_RS01130	COG1028	Short-chain dehydrogenase reductase Sdr
C2U32_RS01135	COG2271	Major facilitator Superfamily
C2U32_RS01140	COG3959	Transketolase, thiamine diphosphate binding domain
C2U32_RS01145	COG3958	Transketolase
C2U32_RS01155	COG0306	phosphate transporter
C2U32_RS01175	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2U32_RS01220	COG4181	ATPase activity
C2U32_RS01225	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C2U32_RS01255	COG0583	DNA-binding transcription factor activity
C2U32_RS01265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U32_RS01270	COG1773	rubredoxin
C2U32_RS01320	COG2851	Citrate transporter
C2U32_RS01330	COG1253	flavin adenine dinucleotide binding
C2U32_RS01375	COG0804	urea catabolic process
C2U32_RS01385	COG0830	nickel cation binding
C2U32_RS01400	COG0742	ribosomal rna small subunit methyltransferase
C2U32_RS01405	COG0768	penicillin binding
C2U32_RS01430	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2U32_RS01435	COG2878	Part of a membrane complex involved in electron transport
C2U32_RS01440	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2U32_RS01450	COG3384	dioxygenase
C2U32_RS01480	COG3328	transposase activity
C2U32_RS01495	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2U32_RS01535	COG0006	proline dipeptidase activity
C2U32_RS01540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U32_RS01545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U32_RS01565	COG1279	arginine transmembrane transporter activity
C2U32_RS01570	COG0583	DNA-binding transcription factor activity
C2U32_RS01610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U32_RS01615	COG1388	LysM domain
C2U32_RS01615	COG1388	LysM domain
C2U32_RS01615	COG0741	lytic transglycosylase activity
C2U32_RS01615	COG0741	lytic transglycosylase activity
C2U32_RS01625	COG4174	ABC transporter (Permease)
C2U32_RS01630	COG4239	(ABC) transporter, permease
C2U32_RS01635	COG4172	Belongs to the ABC transporter superfamily
C2U32_RS01640	COG3293	Transposase
C2U32_RS01660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U32_RS01670	COG4251	negative regulation of phosphorylation
C2U32_RS01670	COG3706	GGDEF domain
C2U32_RS01670	COG2203	Gaf domain
C2U32_RS01670	COG5001	Diguanylate cyclase
C2U32_RS01680	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U32_RS01680	COG1902	pentaerythritol trinitrate reductase activity
C2U32_RS01695	COG4269	membrane
C2U32_RS01710	COG2801	Transposase and inactivated derivatives
C2U32_RS01755	COG1113	amino acid transport
C2U32_RS01765	COG0531	amino acid
C2U32_RS01785	COG1012	belongs to the aldehyde dehydrogenase family
C2U32_RS01820	COG2072	flavoprotein involved in K transport
C2U32_RS01830	COG2252	PERMEase
C2U32_RS01835	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C2U32_RS01845	COG3038	cytochrome b561
C2U32_RS01855	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2U32_RS01865	COG0527	aspartate kinase activity
C2U32_RS01920	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U32_RS01925	COG4197	protein conserved in bacteria, prophage-related
C2U32_RS02005	COG5410	chromosome segregation
C2U32_RS02220	COG0582	viral genome integration into host DNA
C2U32_RS02230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2U32_RS02240	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C2U32_RS02255	COG0667	Aldo Keto reductase
C2U32_RS02265	COG1765	OsmC-like protein
C2U32_RS02280	COG0542	response to heat
C2U32_RS02315	COG2885	chlorophyll binding
C2U32_RS02325	COG0625	glutathione transferase activity
C2U32_RS02345	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2U32_RS02370	COG3634	alkyl hydroperoxide reductase activity
C2U32_RS02380	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C2U32_RS02390	COG0450	alkyl hydroperoxide reductase
C2U32_RS02395	COG1643	Atp-dependent helicase
C2U32_RS02410	COG2814	Major facilitator Superfamily
C2U32_RS02415	COG3135	benzoate transporter
C2U32_RS02420	COG1028	Short-chain dehydrogenase reductase Sdr
C2U32_RS02425	COG0543	2 iron, 2 sulfur cluster binding
C2U32_RS02425	COG0633	Ferredoxin
C2U32_RS02430	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C2U32_RS02435	COG4638	Rieske (2fe-2S)
C2U32_RS02440	COG0583	DNA-binding transcription factor activity
C2U32_RS02495	COG1570	exodeoxyribonuclease VII activity
C2U32_RS02525	COG1280	lysine exporter protein (LysE YggA)
C2U32_RS02530	COG1278	Cold shock
C2U32_RS02570	COG2814	Major facilitator Superfamily
C2U32_RS02615	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2U32_RS02625	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C2U32_RS02630	COG1137	ATPase activity
C2U32_RS02635	COG3293	Transposase
C2U32_RS02640	COG1538	Outer membrane efflux protein
C2U32_RS02670	COG4122	O-methyltransferase activity
C2U32_RS02680	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C2U32_RS02695	COG1522	sequence-specific DNA binding
C2U32_RS02700	COG5006	permease, DMT superfamily
C2U32_RS02710	COG1560	Kdo2-lipid A biosynthetic process
C2U32_RS02725	COG2814	Major facilitator Superfamily
C2U32_RS02745	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U32_RS02775	COG0583	DNA-binding transcription factor activity
C2U32_RS02780	COG1914	H( )-stimulated, divalent metal cation uptake system
C2U32_RS02800	COG4770	biotin carboxylase activity
C2U32_RS02805	COG0038	chloride channel
C2U32_RS02825	COG2801	Transposase and inactivated derivatives
C2U32_RS02845	COG1063	alcohol dehydrogenase
C2U32_RS02875	COG3327	negative regulation of DNA-templated transcription, initiation
C2U32_RS02885	COG2050	protein possibly involved in aromatic compounds catabolism
C2U32_RS02910	COG2801	Transposase and inactivated derivatives
C2U32_RS02930	COG2207	Transcriptional regulator
C2U32_RS02945	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U32_RS02950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U32_RS02955	COG2271	Major facilitator Superfamily
C2U32_RS02960	COG0753	catalase activity
C2U32_RS02965	COG3038	cytochrome b561
C2U32_RS02985	COG2267	carboxylic ester hydrolase activity
C2U32_RS02990	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U32_RS02995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U32_RS03000	COG1012	belongs to the aldehyde dehydrogenase family
C2U32_RS03010	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2U32_RS03020	COG1012	belongs to the aldehyde dehydrogenase family
C2U32_RS03025	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U32_RS03030	COG0583	DNA-binding transcription factor activity
C2U32_RS03040	COG1414	Transcriptional regulator
C2U32_RS03045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U32_RS03055	COG1840	ABC-type Fe3 transport system, periplasmic component
C2U32_RS03060	COG3842	ATPase activity
C2U32_RS03075	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2U32_RS03080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U32_RS03085	COG2814	Major facilitator Superfamily
C2U32_RS03090	COG1960	acyl-CoA dehydrogenase activity
C2U32_RS03105	COG1024	Enoyl-CoA hydratase
C2U32_RS03115	COG2814	Major facilitator Superfamily
C2U32_RS03125	COG0183	Belongs to the thiolase family
C2U32_RS03130	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U32_RS03135	COG1028	Short-chain dehydrogenase reductase Sdr
C2U32_RS03140	COG1024	Enoyl-CoA hydratase
C2U32_RS03145	COG1960	acyl-CoA dehydrogenase activity
C2U32_RS03150	COG2814	Major facilitator Superfamily
C2U32_RS03155	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2U32_RS03160	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2U32_RS03170	COG2814	Major facilitator Superfamily
C2U32_RS03180	COG1960	acyl-CoA dehydrogenase activity
C2U32_RS03195	COG0583	DNA-binding transcription factor activity
C2U32_RS03205	COG4770	biotin carboxylase activity
C2U32_RS03210	COG1024	Enoyl-CoA hydratase
C2U32_RS03215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2U32_RS03220	COG1960	acyl-CoA dehydrogenase activity
C2U32_RS03225	COG1309	transcriptional regulator
C2U32_RS03230	COG0318	PFAM AMP-dependent synthetase and ligase
C2U32_RS03250	COG0583	DNA-binding transcription factor activity
C2U32_RS03295	COG1028	Short-chain dehydrogenase reductase Sdr
C2U32_RS03315	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U32_RS03335	COG0784	Response regulator, receiver
C2U32_RS03335	COG2205	protein histidine kinase activity
C2U32_RS03355	COG0765	amino acid transport
C2U32_RS03360	COG0765	amino acid transport
C2U32_RS03370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U32_RS03375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U32_RS03385	COG1280	lysine exporter protein (LysE YggA)
C2U32_RS03390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2U32_RS03395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U32_RS03400	COG1045	serine acetyltransferase
C2U32_RS03415	COG0583	DNA-binding transcription factor activity
C2U32_RS03420	COG0625	glutathione transferase activity
C2U32_RS03425	COG0625	glutathione transferase activity
C2U32_RS03430	COG0583	DNA-binding transcription factor activity
C2U32_RS03440	COG1346	cytolysis
C2U32_RS03460	COG2814	Major facilitator Superfamily
C2U32_RS03470	COG0583	DNA-binding transcription factor activity
C2U32_RS03480	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C2U32_RS03485	COG3052	prosthetic group binding
C2U32_RS03505	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2U32_RS03525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U32_RS03535	COG1294	oxidase, subunit
C2U32_RS03540	COG1271	oxidase subunit
C2U32_RS03565	COG0477	Major facilitator Superfamily
C2U32_RS03575	COG4521	taurine ABC transporter
C2U32_RS03580	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C2U32_RS03585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U32_RS03590	COG2175	clavaminate synthase activity
C2U32_RS03600	COG1953	Uracil, thiamine, allantoin
C2U32_RS03610	COG0583	DNA-binding transcription factor activity
C2U32_RS03620	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C2U32_RS03625	COG3328	transposase activity
C2U32_RS03640	COG0640	Transcriptional regulator
C2U32_RS03645	COG0798	PFAM Bile acid sodium symporter
C2U32_RS03650	COG0583	DNA-binding transcription factor activity
C2U32_RS03665	COG3634	alkyl hydroperoxide reductase activity
C2U32_RS03705	COG0436	Aminotransferase
C2U32_RS03715	COG0386	Belongs to the glutathione peroxidase family
C2U32_RS03755	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2U32_RS03780	COG0012	GTP binding
C2U32_RS03785	COG2011	ABC-type metal ion transport system permease component
C2U32_RS03795	COG3293	Transposase
C2U32_RS03810	COG1464	Belongs to the NlpA lipoprotein family
C2U32_RS03840	COG0765	amino acid transport
C2U32_RS03845	COG0765	amino acid transport
C2U32_RS03850	COG1126	abc transporter atp-binding protein
C2U32_RS03860	COG1522	sequence-specific DNA binding
C2U32_RS03875	COG1309	transcriptional regulator
C2U32_RS03895	COG0583	DNA-binding transcription factor activity
C2U32_RS03905	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2U32_RS03915	COG0697	spore germination
C2U32_RS03965	COG3121	Chaperone
C2U32_RS03970	COG3539	Fimbrial protein
C2U32_RS03995	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2U32_RS03995	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2U32_RS04025	COG3293	Transposase
C2U32_RS04045	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2U32_RS04055	COG2353	YceI-like domain
C2U32_RS04065	COG3698	Phosphodiester glycosidase
C2U32_RS04080	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2U32_RS04085	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U32_RS04085	COG0506	proline dehydrogenase activity
C2U32_RS04085	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U32_RS04095	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U32_RS04100	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2U32_RS04120	COG1132	(ABC) transporter
C2U32_RS04125	COG3122	Protein conserved in bacteria
C2U32_RS04130	COG3619	membrane
C2U32_RS04140	COG0640	Transcriptional regulator
C2U32_RS04145	COG3293	Transposase
C2U32_RS04160	COG2850	peptidyl-arginine hydroxylation
C2U32_RS04165	COG0424	maF-like protein
C2U32_RS04185	COG0191	fructose-bisphosphate aldolase activity
C2U32_RS04190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U32_RS04205	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2U32_RS04215	COG1192	Involved in chromosome partitioning
C2U32_RS04220	COG1475	DNA binding
C2U32_RS04225	COG0811	peptide transport
C2U32_RS04235	COG1132	(ABC) transporter
C2U32_RS04240	COG1663	tetraacyldisaccharide 4'-kinase activity
C2U32_RS04260	COG0084	hydrolase, TatD family'
C2U32_RS04325	COG0776	regulation of translation
C2U32_RS04355	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2U32_RS04360	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2U32_RS04410	COG0339	signal peptide processing
C2U32_RS04420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U32_RS04455	COG0702	epimerase
C2U32_RS04460	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U32_RS04480	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2U32_RS04510	COG0316	Belongs to the HesB IscA family
C2U32_RS04515	COG0822	iron-sulfur transferase activity
C2U32_RS04540	COG0776	regulation of translation
C2U32_RS04545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U32_RS04550	COG2207	Transcriptional regulator
C2U32_RS04555	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U32_RS04560	COG1960	acyl-CoA dehydrogenase activity
C2U32_RS04565	COG1960	acyl-CoA dehydrogenase activity
C2U32_RS04580	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2U32_RS04600	COG4264	IucA IucC family
C2U32_RS04605	COG4264	IucA IucC family
C2U32_RS04615	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U32_RS04660	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C2U32_RS04665	COG0406	alpha-ribazole phosphatase activity
C2U32_RS04680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U32_RS04685	COG0730	response to heat
C2U32_RS04705	COG4773	Receptor
C2U32_RS04710	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U32_RS04725	COG1131	(ABC) transporter
C2U32_RS04730	COG0842	Transport permease protein
C2U32_RS04735	COG0842	Transport permease protein
C2U32_RS04790	COG2226	methyltransferase
C2U32_RS04815	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2U32_RS04850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U32_RS04860	COG0133	tryptophan synthase activity
C2U32_RS04875	COG3706	GGDEF domain
C2U32_RS04900	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2U32_RS04905	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2U32_RS04910	COG0022	dehydrogenase e1 component
C2U32_RS04915	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U32_RS04920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U32_RS04930	COG1063	alcohol dehydrogenase
C2U32_RS04935	COG3781	membrane
C2U32_RS04945	COG3453	Protein conserved in bacteria
C2U32_RS04945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U32_RS04955	COG0730	response to heat
C2U32_RS04970	COG3708	Transcriptional regulator
C2U32_RS04970	COG2207	Transcriptional regulator
C2U32_RS04975	COG1733	regulation of RNA biosynthetic process
C2U32_RS04980	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2U32_RS04990	COG2188	Transcriptional regulator
C2U32_RS05005	COG1027	Aspartate ammonia-lyase
C2U32_RS05020	COG0583	DNA-binding transcription factor activity
C2U32_RS05025	COG0583	DNA-binding transcription factor activity
C2U32_RS05030	COG0183	Belongs to the thiolase family
C2U32_RS05035	COG2031	fatty acid transporter
C2U32_RS05050	COG0583	DNA-binding transcription factor activity
C2U32_RS05075	COG2610	gluconate transmembrane transporter activity
C2U32_RS05080	COG1028	Short-chain dehydrogenase reductase Sdr
C2U32_RS05085	COG2207	Transcriptional regulator
C2U32_RS05100	COG1028	Short-chain dehydrogenase reductase Sdr
C2U32_RS05125	COG0543	2 iron, 2 sulfur cluster binding
C2U32_RS05125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U32_RS05130	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C2U32_RS05135	COG4638	Rieske (2fe-2S)
C2U32_RS05145	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2U32_RS05150	COG4149	molybdate abc transporter
C2U32_RS05155	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C2U32_RS05160	COG1028	Short-chain dehydrogenase reductase Sdr
C2U32_RS05165	COG1535	isochorismatase
C2U32_RS05165	COG3433	isochorismatase activity
C2U32_RS05230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U32_RS05245	COG0753	catalase activity
C2U32_RS05280	COG3539	Fimbrial protein
C2U32_RS05295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U32_RS05300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U32_RS05305	COG0745	RESPONSE REGULATOR receiver
C2U32_RS05310	COG2205	protein histidine kinase activity
C2U32_RS05320	COG2207	Transcriptional regulator
C2U32_RS05335	COG1028	Short-chain dehydrogenase reductase Sdr
C2U32_RS05350	COG0084	hydrolase, TatD family'
C2U32_RS05400	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C2U32_RS05450	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2U32_RS05490	COG1120	ATPase activity
C2U32_RS05495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U32_RS05520	COG2207	Transcriptional regulator
C2U32_RS05525	COG2084	Dehydrogenase
C2U32_RS05535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U32_RS05540	COG0583	DNA-binding transcription factor activity
C2U32_RS05550	COG0129	dihydroxy-acid dehydratase activity
C2U32_RS05555	COG1012	belongs to the aldehyde dehydrogenase family
C2U32_RS05570	COG1566	PFAM secretion protein HlyD family protein
C2U32_RS05595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U32_RS05625	COG0583	DNA-binding transcription factor activity
C2U32_RS05640	COG2188	Transcriptional regulator
C2U32_RS05685	COG0318	PFAM AMP-dependent synthetase and ligase
C2U32_RS05695	COG1960	acyl-CoA dehydrogenase activity
C2U32_RS05705	COG1028	Short-chain dehydrogenase reductase Sdr
C2U32_RS05710	COG1028	Short-chain dehydrogenase reductase Sdr
C2U32_RS05715	COG1028	Short-chain dehydrogenase reductase Sdr
C2U32_RS05720	COG0583	DNA-binding transcription factor activity
C2U32_RS05725	COG1309	transcriptional regulator
C2U32_RS05765	COG1902	pentaerythritol trinitrate reductase activity
C2U32_RS05765	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U32_RS05780	COG1012	belongs to the aldehyde dehydrogenase family
C2U32_RS05800	COG2186	Transcriptional regulator
C2U32_RS05810	COG0583	DNA-binding transcription factor activity
C2U32_RS05815	COG4948	Mandelate Racemase Muconate Lactonizing
C2U32_RS05820	COG4829	muconolactone delta-isomerase
C2U32_RS05830	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2U32_RS05835	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2U32_RS05840	COG0183	Belongs to the thiolase family
C2U32_RS05845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2U32_RS05855	COG1012	belongs to the aldehyde dehydrogenase family
C2U32_RS05865	COG3733	amine oxidase
C2U32_RS05875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U32_RS05885	COG1028	Short-chain dehydrogenase reductase Sdr
C2U32_RS05895	COG4638	Rieske (2fe-2S)
C2U32_RS05915	COG0154	amidase activity
C2U32_RS05925	COG2814	Major facilitator Superfamily
C2U32_RS05950	COG1960	acyl-CoA dehydrogenase activity
C2U32_RS05955	COG0583	DNA-binding transcription factor activity
C2U32_RS05960	COG1414	Transcriptional regulator
C2U32_RS05975	COG2391	methyltransferase activity
C2U32_RS05985	COG4993	Dehydrogenase
C2U32_RS05990	COG3659	wide pore channel activity
C2U32_RS05995	COG3420	alginic acid biosynthetic process
C2U32_RS06000	COG0710	3-dehydroquinate dehydratase activity
C2U32_RS06005	COG3485	protocatechuate 3,4-dioxygenase
C2U32_RS06010	COG3485	protocatechuate 3,4-dioxygenase
C2U32_RS06015	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U32_RS06020	COG2271	Major facilitator Superfamily
C2U32_RS06025	COG0596	Alpha beta hydrolase
C2U32_RS06030	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2U32_RS06035	COG0183	Belongs to the thiolase family
C2U32_RS06040	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2U32_RS06045	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2U32_RS06055	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C2U32_RS06060	COG2323	membrane
C2U32_RS06105	COG1902	pentaerythritol trinitrate reductase activity
C2U32_RS06105	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U32_RS06130	COG0542	response to heat
C2U32_RS06135	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C2U32_RS06165	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2U32_RS06170	COG0569	domain protein
C2U32_RS06175	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U32_RS06190	COG4774	siderophore transport
C2U32_RS06195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U32_RS06205	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2U32_RS06220	COG1294	oxidase, subunit
C2U32_RS06225	COG4890	Cyd operon protein YbgT
C2U32_RS06240	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C2U32_RS06250	COG0552	protein localization to endoplasmic reticulum
C2U32_RS06280	COG0516	GMP reductase activity
C2U32_RS06280	COG0517	IMP dehydrogenase activity
C2U32_RS06285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U32_RS06290	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2U32_RS06300	COG0583	DNA-binding transcription factor activity
C2U32_RS06305	COG0024	Methionine aminopeptidase
C2U32_RS06335	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U32_RS06335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2U32_RS06340	COG1105	Belongs to the carbohydrate kinase PfkB family
C2U32_RS06345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U32_RS06345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U32_RS06345	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2U32_RS06365	COG3300	MHYT domain
C2U32_RS06365	COG5001	Diguanylate cyclase
C2U32_RS06380	COG2135	peptidase activity
C2U32_RS06385	COG0659	secondary active sulfate transmembrane transporter activity
C2U32_RS06400	COG1113	amino acid transport
C2U32_RS06435	COG3293	Transposase
C2U32_RS06450	COG1011	Hydrolase
C2U32_RS06455	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2U32_RS06465	COG2137	regulation of response to DNA damage stimulus
C2U32_RS06480	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U32_RS06500	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U32_RS06515	COG0575	Belongs to the CDS family
C2U32_RS06520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2U32_RS06540	COG3852	Histidine kinase
C2U32_RS06545	COG2204	response regulator
C2U32_RS06605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2U32_RS06610	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2U32_RS06630	COG0697	spore germination
C2U32_RS06635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U32_RS06645	COG0303	'Molybdopterin
C2U32_RS06650	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U32_RS06650	COG0315	cyclic pyranopterin monophosphate synthase activity
C2U32_RS06665	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2U32_RS06670	COG0243	molybdopterin cofactor binding
C2U32_RS06680	COG0243	molybdopterin cofactor binding
C2U32_RS06685	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U32_RS06690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U32_RS06690	COG2146	nitrite reductase [NAD(P)H] activity
C2U32_RS06700	COG0745	RESPONSE REGULATOR receiver
C2U32_RS06705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U32_RS06705	COG1116	anion transmembrane transporter activity
C2U32_RS06725	COG0511	ligase activity, forming carbon-carbon bonds
C2U32_RS06740	COG2814	Major facilitator Superfamily
C2U32_RS06760	COG0069	glutamate synthase activity
C2U32_RS06780	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2U32_RS06790	COG1454	alcohol dehydrogenase
C2U32_RS06795	COG0824	Thioesterase
C2U32_RS06805	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2U32_RS06820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2U32_RS06825	COG2030	dehydratase
C2U32_RS06835	COG0183	Belongs to the thiolase family
C2U32_RS06845	COG0583	DNA-binding transcription factor activity
C2U32_RS06850	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2U32_RS06860	COG1522	sequence-specific DNA binding
C2U32_RS06865	COG3135	benzoate transporter
C2U32_RS06875	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2U32_RS06890	COG0589	response to stress
C2U32_RS06895	COG0488	(ABC) transporter
C2U32_RS06915	COG4773	Receptor
C2U32_RS06945	COG0668	transmembrane transport
C2U32_RS06955	COG1309	transcriptional regulator
C2U32_RS06965	COG2801	Transposase and inactivated derivatives
C2U32_RS06985	COG1605	Chorismate mutase
C2U32_RS07025	COG0308	aminopeptidase N
C2U32_RS07050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U32_RS07055	COG1454	alcohol dehydrogenase
C2U32_RS07075	COG0531	amino acid
C2U32_RS07080	COG4303	Ethanolamine ammonia lyase large subunit
C2U32_RS07085	COG4302	ethanolamine ammonia-lyase activity
C2U32_RS07090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U32_RS07090	COG0519	Catalyzes the synthesis of GMP from XMP
C2U32_RS07095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U32_RS07120	COG0697	spore germination
C2U32_RS07125	COG1923	regulation of RNA biosynthetic process
C2U32_RS07135	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2U32_RS07140	COG0802	atpase or kinase
C2U32_RS07160	COG1187	pseudouridine synthase activity
C2U32_RS07175	COG0583	DNA-binding transcription factor activity
C2U32_RS07205	COG2814	Major facilitator Superfamily
C2U32_RS07210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U32_RS07240	COG0729	surface antigen
C2U32_RS07245	COG0477	Major facilitator Superfamily
C2U32_RS07260	COG0174	glutamine synthetase
C2U32_RS07265	COG0745	RESPONSE REGULATOR receiver
C2U32_RS07270	COG2205	protein histidine kinase activity
C2U32_RS07280	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C2U32_RS07285	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C2U32_RS07310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U32_RS07315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U32_RS07320	COG1960	acyl-CoA dehydrogenase activity
C2U32_RS07350	COG0583	DNA-binding transcription factor activity
C2U32_RS07370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U32_RS07380	COG3658	cytochrome
C2U32_RS07385	COG1215	transferase activity, transferring glycosyl groups
C2U32_RS07390	COG1649	PFAM Uncharacterised BCR, COG1649
C2U32_RS07390	COG0726	polysaccharide deacetylase
C2U32_RS07415	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2U32_RS07420	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2U32_RS07430	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2U32_RS07455	COG0305	Participates in initiation and elongation during chromosome replication
C2U32_RS07460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U32_RS07470	COG1305	Transglutaminase-like
C2U32_RS07480	COG2308	Evidence 4 Homologs of previously reported genes of
C2U32_RS07510	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C2U32_RS07515	COG0138	bifunctional purine biosynthesis protein purh
C2U32_RS07520	COG0151	Belongs to the GarS family
C2U32_RS07525	COG1464	Belongs to the NlpA lipoprotein family
C2U32_RS07530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U32_RS07535	COG2011	ABC-type metal ion transport system permease component
C2U32_RS07550	COG1301	dicarboxylic acid transport
C2U32_RS07580	COG1794	racemase activity, acting on amino acids and derivatives
C2U32_RS07595	COG3008	intermembrane lipid transfer
C2U32_RS07595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U32_RS07600	COG2995	paraquat-inducible protein a
C2U32_RS07645	COG1051	belongs to the nudix hydrolase family
C2U32_RS07650	COG0477	Major facilitator Superfamily
C2U32_RS07705	COG2186	Transcriptional regulator
C2U32_RS07715	COG0786	glutamate:sodium symporter activity
C2U32_RS07720	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2U32_RS07745	COG3111	PFAM Bacterial OB fold (BOF) protein
C2U32_RS07815	COG0515	serine threonine protein kinase
C2U32_RS07815	COG2815	serine threonine protein kinase
C2U32_RS07845	COG1610	YqeY-like protein
C2U32_RS07850	COG4783	chaperone-mediated protein folding
C2U32_RS07875	COG1286	toxin biosynthetic process
C2U32_RS07905	COG0778	Nitroreductase
C2U32_RS07915	COG0513	Belongs to the DEAD box helicase family
C2U32_RS07935	COG2363	Small membrane protein
C2U32_RS07965	COG4650	regulator
C2U32_RS07970	COG1234	tRNA 3'-trailer cleavage
C2U32_RS07975	COG1690	Belongs to the RtcB family
C2U32_RS07995	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2U32_RS08005	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2U32_RS08015	COG2819	hydrolase of the alpha beta superfamily
C2U32_RS08020	COG1960	acyl-CoA dehydrogenase activity
C2U32_RS08025	COG1301	dicarboxylic acid transport
C2U32_RS08040	COG3139	Protein of unknown function (DUF1315)
C2U32_RS08045	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2U32_RS08050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U32_RS08060	COG0494	nUDIX hydrolase
C2U32_RS08070	COG0642	Histidine kinase
C2U32_RS08085	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U32_RS08095	COG1720	tRNA m6t6A37 methyltransferase activity
C2U32_RS08125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U32_RS08130	COG0826	peptidase U32
C2U32_RS08135	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U32_RS08145	COG4598	ABC transporter
C2U32_RS08150	COG4160	amino acid transport
C2U32_RS08155	COG4215	(ABC) transporter
C2U32_RS08170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U32_RS08215	COG1131	(ABC) transporter
C2U32_RS08220	COG0842	Transport permease protein
C2U32_RS08235	COG0772	Belongs to the SEDS family
C2U32_RS08240	COG2951	lytic endotransglycosylase activity
C2U32_RS08265	COG2207	Transcriptional regulator
C2U32_RS08280	COG0052	Belongs to the universal ribosomal protein uS2 family
C2U32_RS08285	COG0024	Methionine aminopeptidase
C2U32_RS08295	COG2223	nitrite transmembrane transporter activity
C2U32_RS08305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U32_RS08310	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2U32_RS08315	COG1960	acyl-CoA dehydrogenase activity
C2U32_RS08330	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C2U32_RS08335	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C2U32_RS08340	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2U32_RS08360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U32_RS08365	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2U32_RS08370	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2U32_RS08405	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C2U32_RS08415	COG0174	glutamine synthetase
C2U32_RS08435	COG0582	viral genome integration into host DNA
C2U32_RS08510	COG2314	TM2 domain
C2U32_RS08570	COG3566	protein conserved in bacteria
C2U32_RS08590	COG3567	Phage-associated protein, HI1409 family
C2U32_RS08595	COG5410	chromosome segregation
C2U32_RS08735	COG0512	Glutamine amidotransferase of anthranilate synthase
C2U32_RS08740	COG0308	aminopeptidase N
C2U32_RS08770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2U32_RS08780	COG0302	gtp cyclohydrolase
C2U32_RS08800	COG3739	integral membrane protein
C2U32_RS08820	COG2977	Belongs to the P-Pant transferase superfamily
C2U32_RS08825	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C2U32_RS08830	COG1132	(ABC) transporter
C2U32_RS08835	COG1132	(ABC) transporter
C2U32_RS08850	COG1535	isochorismatase
C2U32_RS08850	COG3433	isochorismatase activity
C2U32_RS08855	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2U32_RS08860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U32_RS08870	COG4774	siderophore transport
C2U32_RS08875	COG4607	ABC-type enterochelin transport system periplasmic component
C2U32_RS08880	COG4604	ABC transporter, ATP-binding protein
C2U32_RS08885	COG4605	iron ion homeostasis
C2U32_RS08890	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U32_RS08895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U32_RS08910	COG2964	Protein conserved in bacteria
C2U32_RS08920	COG1741	Belongs to the pirin family
C2U32_RS08935	COG2801	Transposase and inactivated derivatives
C2U32_RS08955	COG2879	small protein
C2U32_RS08960	COG1966	Carbon starvation protein
C2U32_RS08980	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2U32_RS09005	COG1067	ATP-dependent peptidase activity
C2U32_RS09010	COG0583	DNA-binding transcription factor activity
C2U32_RS09035	COG1686	Belongs to the peptidase S11 family
C2U32_RS09040	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2U32_RS09075	COG0616	signal peptide processing
C2U32_RS09080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2U32_RS09090	COG0573	inorganic phosphate transmembrane transporter activity
C2U32_RS09095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2U32_RS09100	COG1113	amino acid transport
C2U32_RS09105	COG3961	Belongs to the TPP enzyme family
C2U32_RS09110	COG1522	sequence-specific DNA binding
C2U32_RS09120	COG0076	glutamate decarboxylase activity
C2U32_RS09125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2U32_RS09140	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2U32_RS09150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U32_RS09185	COG0352	thiamine-phosphate diphosphorylase activity
C2U32_RS09210	COG0612	Peptidase, M16
C2U32_RS09220	COG1823	symporter activity
C2U32_RS09225	COG0583	DNA-binding transcription factor activity
C2U32_RS09230	COG0477	Major facilitator Superfamily
C2U32_RS09255	COG1187	pseudouridine synthase activity
C2U32_RS09270	COG1686	Belongs to the peptidase S11 family
C2U32_RS09275	COG1252	NADH dehydrogenase
C2U32_RS09285	COG0415	Belongs to the DNA photolyase family
C2U32_RS09300	COG1215	transferase activity, transferring glycosyl groups
C2U32_RS09335	COG2070	2-Nitropropane dioxygenase
C2U32_RS09390	COG0556	nucleotide-excision repair
C2U32_RS09410	COG0436	Aminotransferase
C2U32_RS09440	COG4221	oxidoreductase activity
C2U32_RS09450	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2U32_RS09455	COG1381	Involved in DNA repair and RecF pathway recombination
C2U32_RS09465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C2U32_RS09480	COG0681	Belongs to the peptidase S26 family
C2U32_RS09495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U32_RS09515	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2U32_RS09520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2U32_RS09525	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2U32_RS09535	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2U32_RS09540	COG4208	sulfate ABC transporter
C2U32_RS09545	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2U32_RS09550	COG0583	DNA-binding transcription factor activity
C2U32_RS09555	COG4625	pathogenesis
C2U32_RS09570	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2U32_RS09585	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2U32_RS09595	COG1056	cytidyltransferase-related domain
C2U32_RS09595	COG1051	belongs to the nudix hydrolase family
C2U32_RS09600	COG1024	Enoyl-CoA hydratase
C2U32_RS09610	COG2814	Major facilitator Superfamily
C2U32_RS09615	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2U32_RS09615	COG0047	phosphoribosylformylglycinamidine synthase activity
C2U32_RS09635	COG1473	amidohydrolase
C2U32_RS09640	COG0824	Thioesterase
C2U32_RS09660	COG0823	Involved in the tonB-independent uptake of proteins
C2U32_RS09680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U32_RS09730	COG0628	permease
C2U32_RS09740	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2U32_RS09745	COG0596	Alpha beta hydrolase
C2U32_RS09750	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2U32_RS09750	COG0616	signal peptide processing
C2U32_RS09765	COG1136	(ABC) transporter
C2U32_RS09770	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2U32_RS09800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U32_RS09820	COG0463	Glycosyl transferase, family 2
C2U32_RS09850	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C2U32_RS09855	COG1280	lysine exporter protein (LysE YggA)
C2U32_RS09865	COG0019	diaminopimelate decarboxylase activity
C2U32_RS09875	COG1113	amino acid transport
C2U32_RS09890	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C2U32_RS09900	COG3339	Conserved Protein
C2U32_RS09905	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2U32_RS09910	COG0243	molybdopterin cofactor binding
C2U32_RS09915	COG1929	Belongs to the glycerate kinase type-1 family
C2U32_RS09930	COG0778	Nitroreductase
C2U32_RS09955	COG2801	Transposase and inactivated derivatives
C2U32_RS09990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U32_RS10005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U32_RS10030	COG0741	lytic transglycosylase activity
C2U32_RS10050	COG0584	glycerophosphoryl diester phosphodiesterase
C2U32_RS10060	COG3293	Transposase
C2U32_RS10085	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2U32_RS10090	COG1597	lipid kinase activity
C2U32_RS10105	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2U32_RS10120	COG2801	Transposase and inactivated derivatives
C2U32_RS10175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2U32_RS10180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U32_RS10205	COG0505	Belongs to the CarA family
C2U32_RS10220	COG1309	transcriptional regulator
C2U32_RS10225	COG0251	oxidation-reduction process
C2U32_RS10235	COG0589	response to stress
C2U32_RS10295	COG2321	neutral zinc metallopeptidase
C2U32_RS10300	COG2354	Protein conserved in bacteria
C2U32_RS10320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U32_RS10345	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2U32_RS10350	COG1053	succinate dehydrogenase
C2U32_RS10355	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C2U32_RS10360	COG2009	succinate dehydrogenase
C2U32_RS10380	COG3293	Transposase
C2U32_RS10400	COG2921	Belongs to the UPF0250 family
C2U32_RS10405	COG0321	lipoyl(octanoyl) transferase activity
C2U32_RS10420	COG0531	amino acid
C2U32_RS10430	COG1733	regulation of RNA biosynthetic process
C2U32_RS10435	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2U32_RS10440	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U32_RS10440	COG1648	precorrin-2 dehydrogenase activity
C2U32_RS10455	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2U32_RS10485	COG0671	phosphoesterase, PA-phosphatase related
C2U32_RS10490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U32_RS10500	COG1538	Outer membrane efflux protein
C2U32_RS10505	COG0393	Putative heavy-metal-binding
C2U32_RS10510	COG0393	Putative heavy-metal-binding
C2U32_RS10520	COG1028	Short-chain dehydrogenase reductase Sdr
C2U32_RS10530	COG0525	valine-tRNA ligase activity
C2U32_RS10550	COG0583	DNA-binding transcription factor activity
C2U32_RS10560	COG0004	ammonium transporteR
C2U32_RS10570	COG0642	Histidine kinase
C2U32_RS10575	COG0745	RESPONSE REGULATOR receiver
C2U32_RS10580	COG2194	sulfuric ester hydrolase activity
C2U32_RS10585	COG3328	transposase activity
C2U32_RS10605	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2U32_RS10620	COG2315	Protein conserved in bacteria
C2U32_RS10625	COG0142	geranyltranstransferase activity
C2U32_RS10630	COG2828	Protein conserved in bacteria
C2U32_RS10635	COG1113	amino acid transport
C2U32_RS10655	COG2207	Transcriptional regulator
C2U32_RS10680	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2U32_RS10690	COG0560	Phosphoserine phosphatase
C2U32_RS10700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U32_RS10710	COG1530	ribonuclease E activity
C2U32_RS10715	COG0424	maF-like protein
C2U32_RS10720	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2U32_RS10725	COG1792	Involved in formation and maintenance of cell shape
C2U32_RS10730	COG1077	Cell shape determining protein MreB Mrl
C2U32_RS10735	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2U32_RS10745	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2U32_RS10770	COG3590	peptidase
C2U32_RS10800	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C2U32_RS10805	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2U32_RS10810	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2U32_RS10815	COG1115	amino acid carrier protein
C2U32_RS10840	COG1289	transmembrane transporter activity
C2U32_RS10850	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2U32_RS10890	COG1376	ErfK ybiS ycfS ynhG family protein
C2U32_RS10895	COG2832	Protein of unknown function (DUF454)
C2U32_RS10905	COG5510	response to toxic substance
C2U32_RS10920	COG0840	transmembrane signaling receptor activity
C2U32_RS10960	COG3422	double-strand break repair
C2U32_RS10965	COG2824	Alkylphosphonate utilization operon protein PhnA
C2U32_RS10970	COG3189	MarR family transcriptional regulator
C2U32_RS10975	COG0596	Alpha beta hydrolase
C2U32_RS10980	COG0778	Nitroreductase
C2U32_RS10985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U32_RS10990	COG1335	isochorismatase
C2U32_RS10995	COG0251	oxidation-reduction process
C2U32_RS11000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U32_RS11005	COG2233	PERMEase
C2U32_RS11020	COG0354	folic acid binding
C2U32_RS11025	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U32_RS11035	COG0679	Auxin Efflux Carrier
C2U32_RS11040	COG1902	pentaerythritol trinitrate reductase activity
C2U32_RS11060	COG2094	Belongs to the DNA glycosylase MPG family
C2U32_RS11085	COG1217	gtp-binding protein TYPA
C2U32_RS11090	COG2233	PERMEase
C2U32_RS11100	COG0833	amino acid
C2U32_RS11105	COG1690	Belongs to the RtcB family
C2U32_RS11115	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C2U32_RS11115	COG2885	chlorophyll binding
C2U32_RS11125	COG0183	Belongs to the thiolase family
C2U32_RS11145	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U32_RS11165	COG2207	Transcriptional regulator
C2U32_RS11170	COG0183	Belongs to the thiolase family
C2U32_RS11200	COG1272	protein, Hemolysin III
C2U32_RS11205	COG0477	Major facilitator Superfamily
C2U32_RS11220	COG0450	alkyl hydroperoxide reductase
C2U32_RS11250	COG0285	dihydrofolate synthase activity
C2U32_RS11305	COG2096	Adenosyltransferase
C2U32_RS11325	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C2U32_RS11330	COG0745	RESPONSE REGULATOR receiver
C2U32_RS11335	COG2205	protein histidine kinase activity
C2U32_RS11350	COG1960	acyl-CoA dehydrogenase activity
C2U32_RS11355	COG1960	acyl-CoA dehydrogenase activity
C2U32_RS11405	COG1215	transferase activity, transferring glycosyl groups
C2U32_RS11420	COG1091	dTDP-4-dehydrorhamnose reductase activity
C2U32_RS11435	COG0438	transferase activity, transferring glycosyl groups
C2U32_RS11440	COG0726	polysaccharide deacetylase
C2U32_RS11455	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C2U32_RS11460	COG2205	protein histidine kinase activity
C2U32_RS11490	COG1862	Preprotein translocase
C2U32_RS11500	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U32_RS11520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2U32_RS11530	COG3781	membrane
C2U32_RS11535	COG0613	PHP domain protein
C2U32_RS11545	COG2350	Protein conserved in bacteria
C2U32_RS11575	COG1607	acyl-coa hydrolase
C2U32_RS11635	COG2199	diguanylate cyclase activity
C2U32_RS11645	COG1408	metallophosphoesterase
C2U32_RS11650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U32_RS11660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2U32_RS11680	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2U32_RS11685	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2U32_RS11700	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2U32_RS11710	COG2969	positive regulation of protein catabolic process
C2U32_RS11730	COG1960	acyl-CoA dehydrogenase activity
C2U32_RS11735	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2U32_RS11750	COG1309	transcriptional regulator
C2U32_RS11755	COG1960	acyl-CoA dehydrogenase activity
C2U32_RS11800	COG1183	phosphatidylcholine synthase activity
C2U32_RS11805	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2U32_RS11835	COG1196	nuclear chromosome segregation
C2U32_RS11835	COG0741	lytic transglycosylase activity
C2U32_RS11835	COG0739	heme binding
C2U32_RS11845	COG1702	phosphate starvation-inducible protein PhoH
C2U32_RS11880	COG1295	ribonuclease BN
C2U32_RS11885	COG0697	spore germination
C2U32_RS11890	COG2169	Transcriptional regulator
C2U32_RS11895	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2U32_RS11950	COG0557	exoribonuclease II activity
C2U32_RS11955	COG0339	signal peptide processing
C2U32_RS11960	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C2U32_RS11990	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2U32_RS11995	COG1960	acyl-CoA dehydrogenase activity
C2U32_RS12150	COG0626	cystathionine gamma-synthase activity
C2U32_RS12155	COG0433	COG0433 Predicted ATPase
C2U32_RS12165	COG1017	nitric oxide dioxygenase activity
C2U32_RS12165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U32_RS12170	COG1959	2 iron, 2 sulfur cluster binding
C2U32_RS12185	COG1301	dicarboxylic acid transport
C2U32_RS12190	COG1946	Acyl-CoA thioesterase
C2U32_RS12210	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2U32_RS12215	COG1040	competence protein
C2U32_RS12220	COG0494	nUDIX hydrolase
C2U32_RS12230	COG0598	Magnesium transport protein CorA
C2U32_RS12240	COG2854	intermembrane phospholipid transfer
C2U32_RS12250	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2U32_RS12255	COG1127	ABC transporter
C2U32_RS12260	COG0513	Belongs to the DEAD box helicase family
C2U32_RS12280	COG0408	coproporphyrinogen oxidase activity
C2U32_RS12295	COG1960	acyl-CoA dehydrogenase activity
C2U32_RS12305	COG1983	PspC domain protein
C2U32_RS12310	COG0517	IMP dehydrogenase activity
C2U32_RS12355	COG0583	DNA-binding transcription factor activity
C2U32_RS12395	COG1012	belongs to the aldehyde dehydrogenase family
C2U32_RS12405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U32_RS12410	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2U32_RS12415	COG0833	amino acid
C2U32_RS12450	COG0628	permease
C2U32_RS12460	COG1289	transmembrane transporter activity
C2U32_RS12480	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2U32_RS12490	COG0277	FAD linked oxidase domain protein
C2U32_RS12495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U32_RS12520	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2U32_RS12525	COG5380	lipid catabolic process
C2U32_RS12545	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2U32_RS12595	COG0194	GDP metabolic process
C2U32_RS12610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U32_RS12630	COG3307	-O-antigen
C2U32_RS12645	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2U32_RS12650	COG1704	LemA family
C2U32_RS12660	COG0493	'glutamate synthase
C2U32_RS12665	COG0070	glutamate synthase
C2U32_RS12665	COG0069	glutamate synthase activity
C2U32_RS12665	COG0067	glutamate synthase
C2U32_RS12715	COG2226	methyltransferase
C2U32_RS12730	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2U32_RS12735	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2U32_RS12780	COG0833	amino acid
C2U32_RS12865	COG0488	(ABC) transporter
C2U32_RS12870	COG2873	o-acetylhomoserine
C2U32_RS12875	COG4221	oxidoreductase activity
C2U32_RS12880	COG0659	secondary active sulfate transmembrane transporter activity
C2U32_RS12905	COG0427	acetyl-CoA hydrolase
C2U32_RS12935	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2U32_RS12975	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2U32_RS13055	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2U32_RS13070	COG2801	Transposase and inactivated derivatives
C2U32_RS13080	COG0667	Aldo Keto reductase
C2U32_RS13095	COG3293	Transposase
C2U32_RS13105	COG0583	DNA-binding transcription factor activity
C2U32_RS13110	COG2814	Major facilitator Superfamily
C2U32_RS13235	COG1335	isochorismatase
C2U32_RS13245	COG1012	belongs to the aldehyde dehydrogenase family
C2U32_RS13250	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2U32_RS13260	COG1113	amino acid transport
C2U32_RS13270	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2U32_RS13285	COG2814	Major facilitator Superfamily
C2U32_RS13295	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2U32_RS13295	COG0351	phosphomethylpyrimidine kinase
C2U32_RS13295	COG0352	thiamine-phosphate diphosphorylase activity
C2U32_RS13315	COG1309	transcriptional regulator
C2U32_RS13335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2U32_RS13345	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U32_RS13350	COG3162	membrane
C2U32_RS13355	COG2205	protein histidine kinase activity
C2U32_RS13355	COG2198	Histidine kinase
C2U32_RS13355	COG0784	Response regulator, receiver
C2U32_RS13380	COG1522	sequence-specific DNA binding
C2U32_RS13385	COG1335	isochorismatase
C2U32_RS13390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U32_RS13400	COG0668	transmembrane transport
C2U32_RS13405	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2U32_RS13410	COG1519	Transferase
C2U32_RS13415	COG1902	pentaerythritol trinitrate reductase activity
C2U32_RS13435	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2U32_RS13460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U32_RS13460	COG0426	domain, Protein
C2U32_RS13465	COG4774	siderophore transport
C2U32_RS13470	COG2119	membrane
C2U32_RS13480	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U32_RS13490	COG4942	peptidase
C2U32_RS13505	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2U32_RS13515	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2U32_RS13535	COG0189	ligase activity
C2U32_RS13560	COG0708	Exodeoxyribonuclease III
C2U32_RS13565	COG1393	Belongs to the ArsC family
C2U32_RS13580	COG3706	GGDEF domain
C2U32_RS13615	COG2351	hydroxyisourate hydrolase activity
C2U32_RS13620	COG2233	PERMEase
C2U32_RS13630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U32_RS13640	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C2U32_RS13645	COG1028	Short-chain dehydrogenase reductase Sdr
C2U32_RS13655	COG3150	esterase
C2U32_RS13675	COG2918	glutathione biosynthetic process
C2U32_RS13690	COG2733	membrane
C2U32_RS13695	COG0436	Aminotransferase
C2U32_RS13700	COG0534	Mate efflux family protein
C2U32_RS13790	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C2U32_RS13795	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2U32_RS13805	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2U32_RS13855	COG0010	Belongs to the arginase family
C2U32_RS13885	COG2188	Transcriptional regulator
C2U32_RS13895	COG0523	cobalamin synthesis protein
C2U32_RS13905	COG1113	amino acid transport
C2U32_RS13915	COG0625	glutathione transferase activity
C2U32_RS13935	COG1683	Conserved Protein
C2U32_RS13940	COG0534	Mate efflux family protein
C2U32_RS13945	COG0385	Bile acid
C2U32_RS13950	COG1335	isochorismatase
C2U32_RS13955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U32_RS13975	COG2116	formate transmembrane transporter activity
C2U32_RS13980	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2U32_RS13985	COG2133	pyrroloquinoline quinone binding
C2U32_RS13990	COG2983	Belongs to the UPF0260 family
C2U32_RS14010	COG1194	a g-specific adenine glycosylase
C2U32_RS14025	COG2818	Glycosylase
C2U32_RS14030	COG1064	alcohol dehydrogenase
C2U32_RS14035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U32_RS14050	COG0583	DNA-binding transcription factor activity
C2U32_RS14055	COG0656	L-ascorbic acid biosynthetic process
C2U32_RS14060	COG2814	Major facilitator Superfamily
C2U32_RS14095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U32_RS14110	COG2233	PERMEase
C2U32_RS14115	COG0583	DNA-binding transcription factor activity
C2U32_RS14150	COG0733	neurotransmitter:sodium symporter activity
C2U32_RS14190	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2U32_RS14195	COG0657	acetylesterase activity
C2U32_RS14265	COG2951	lytic endotransglycosylase activity
C2U32_RS14270	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2U32_RS14290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U32_RS14300	COG0671	phosphoesterase, PA-phosphatase related
C2U32_RS14305	COG0861	Integral membrane protein TerC family
C2U32_RS14345	COG0402	S-adenosylhomocysteine deaminase activity
C2U32_RS14360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U32_RS14365	COG1230	cation diffusion facilitator family transporter
C2U32_RS14380	COG0706	membrane insertase activity
C2U32_RS14405	COG0592	DNA-directed DNA polymerase activity
C2U32_RS14415	COG0187	DNA topoisomerase II activity
C2U32_RS14425	COG0586	Pfam SNARE associated Golgi protein
C2U32_RS14430	COG0488	(ABC) transporter
C2U32_RS14455	COG0596	Alpha beta hydrolase
C2U32_RS14460	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C2U32_RS14465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2U32_RS14510	COG1047	Peptidyl-prolyl cis-trans
C2U32_RS14520	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2U32_RS14525	COG0196	riboflavin kinase activity
C2U32_RS14535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2U32_RS14540	COG3328	transposase activity
C2U32_RS14545	COG1309	transcriptional regulator
C2U32_RS14550	COG1116	anion transmembrane transporter activity
C2U32_RS14555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U32_RS14560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U32_RS14565	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U32_RS14570	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U32_RS14590	COG1028	Short-chain dehydrogenase reductase Sdr
C2U32_RS14595	COG0546	phosphoglycolate phosphatase activity
C2U32_RS14655	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2U32_RS14660	COG0728	peptidoglycan biosynthetic process
C2U32_RS14685	COG1596	polysaccharide export
C2U32_RS14690	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C2U32_RS14715	COG1215	transferase activity, transferring glycosyl groups
C2U32_RS14720	COG2244	polysaccharide biosynthetic process
C2U32_RS14755	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2U32_RS14770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2U32_RS14775	COG3328	transposase activity
C2U32_RS14785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2U32_RS14795	COG2186	Transcriptional regulator
C2U32_RS14805	COG0277	FAD linked oxidase domain protein
C2U32_RS14810	COG1448	Aminotransferase
C2U32_RS14820	COG1802	Transcriptional regulator
C2U32_RS14835	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2U32_RS14865	COG0564	pseudouridine synthase activity
C2U32_RS14905	COG0251	oxidation-reduction process
C2U32_RS14910	COG1113	amino acid transport
C2U32_RS14915	COG1113	amino acid transport
C2U32_RS14950	COG4115	mRNA cleavage
C2U32_RS14960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2U32_RS14965	COG3550	peptidyl-serine autophosphorylation
C2U32_RS15040	COG1538	Outer membrane efflux protein
C2U32_RS15045	COG1132	(ABC) transporter
C2U32_RS15065	COG0753	catalase activity
C2U32_RS15080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U32_RS15090	COG3756	Protein conserved in bacteria
C2U32_RS15125	COG0271	Belongs to the BolA IbaG family
C2U32_RS15150	COG0586	Pfam SNARE associated Golgi protein
C2U32_RS15155	COG2259	Doxx family
C2U32_RS15160	COG4399	Belongs to the UPF0754 family
C2U32_RS15165	COG0519	Catalyzes the synthesis of GMP from XMP
C2U32_RS15165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U32_RS15210	COG0281	malic enzyme
C2U32_RS15215	COG2837	iron assimilation
C2U32_RS15220	COG1280	lysine exporter protein (LysE YggA)
C2U32_RS15225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2U32_RS15230	COG1121	(ABC) transporter
C2U32_RS15300	COG0386	Belongs to the glutathione peroxidase family
C2U32_RS15315	COG1309	transcriptional regulator
C2U32_RS15320	COG0697	spore germination
C2U32_RS15330	COG0758	DNA mediated transformation
C2U32_RS15365	COG1309	transcriptional regulator
C2U32_RS15400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2U32_RS15410	COG0655	NAD(P)H dehydrogenase (quinone) activity
C2U32_RS15445	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U32_RS15465	COG0477	Major facilitator Superfamily
C2U32_RS15475	COG1253	flavin adenine dinucleotide binding
C2U32_RS15485	COG2860	membrane
C2U32_RS15490	COG0477	Major facilitator Superfamily
C2U32_RS15500	COG0318	PFAM AMP-dependent synthetase and ligase
C2U32_RS15515	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C2U32_RS15530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U32_RS15540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U32_RS15545	COG0606	chelatase, subunit chli
C2U32_RS15610	COG2205	protein histidine kinase activity
C2U32_RS15625	COG2132	Multicopper oxidase
C2U32_RS15665	COG3293	Transposase
C2U32_RS15685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2U32_RS15715	COG0606	chelatase, subunit chli
C2U32_RS15725	COG0347	Belongs to the P(II) protein family
C2U32_RS15730	COG0004	ammonium transporteR
C2U32_RS15740	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U32_RS15740	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U32_RS15785	COG0795	lipopolysaccharide-transporting ATPase activity
C2U32_RS15790	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C2U32_RS15795	COG0793	Belongs to the peptidase S41A family
C2U32_RS15810	COG2197	response regulator
C2U32_RS15820	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2U32_RS15830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U32_RS15835	COG4974	Belongs to the 'phage' integrase family
C2U32_RS15860	COG0772	Belongs to the SEDS family
C2U32_RS15865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U32_RS15870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2U32_RS15875	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2U32_RS15900	COG0697	spore germination
C2U32_RS15905	COG1538	Outer membrane efflux protein
C2U32_RS15930	COG3293	Transposase
C2U32_RS15945	COG0181	hydroxymethylbilane synthase activity
C2U32_RS15990	COG1716	ATPase activity
C2U32_RS15995	COG0546	phosphoglycolate phosphatase activity
C2U32_RS16095	COG2056	Na+-H+ antiporter family
C2U32_RS16110	COG0326	Molecular chaperone. Has ATPase activity
C2U32_RS16125	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C2U32_RS16195	COG3328	transposase activity
C2U32_RS16205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2U32_RS16210	COG2169	Transcriptional regulator
C2U32_RS16210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2U32_RS16240	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2U32_RS16250	COG0497	DNA recombination
C2U32_RS16265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U32_RS16275	COG0237	dephospho-CoA kinase activity
C2U32_RS16325	COG0195	Participates in both transcription termination and antitermination
C2U32_RS16340	COG1320	monovalent cation:proton antiporter activity
C2U32_RS16345	COG2212	antiporter activity
C2U32_RS16350	COG1863	multisubunit Na H antiporter MnhE subunit
C2U32_RS16355	COG0651	ATP synthesis coupled electron transport
C2U32_RS16360	COG1006	Multisubunit Na H antiporter MnhC subunit
C2U32_RS16365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2U32_RS16365	COG2111	Na H antiporter
C2U32_RS16380	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2U32_RS16385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U32_RS16400	COG2226	methyltransferase
C2U32_RS16420	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C2U32_RS16425	COG1074	ATP-dependent DNA helicase activity
C2U32_RS16430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U32_RS16435	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2U32_RS16450	COG0598	Magnesium transport protein CorA
C2U32_RS16455	COG0789	Transcriptional regulator
C2U32_RS16460	COG0484	heat shock protein binding
C2U32_RS16475	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2U32_RS16475	COG0475	glutathione-regulated potassium exporter activity
C2U32_RS16480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2U32_RS16500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U32_RS16510	COG4535	Mg2 and Co2 transporter CorC
C2U32_RS16515	COG0425	Belongs to the sulfur carrier protein TusA family
C2U32_RS16520	COG0644	oxidoreductase
C2U32_RS16520	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C2U32_RS16530	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2U32_RS16545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U32_RS16550	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C2U32_RS16560	COG0493	'glutamate synthase
C2U32_RS16560	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U32_RS16590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C2U32_RS16605	COG0534	Mate efflux family protein
C2U32_RS16615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U32_RS16640	COG0318	PFAM AMP-dependent synthetase and ligase
C2U32_RS16645	COG1530	ribonuclease E activity
C2U32_RS16660	COG0546	phosphoglycolate phosphatase activity
C2U32_RS16665	COG2378	regulation of single-species biofilm formation
C2U32_RS16670	COG0625	glutathione transferase activity
C2U32_RS16680	COG0583	DNA-binding transcription factor activity
C2U32_RS16735	COG0473	3-isopropylmalate dehydrogenase activity
C2U32_RS16790	COG3293	Transposase
C2U32_RS16795	COG1301	dicarboxylic acid transport
C2U32_RS16805	COG1560	Kdo2-lipid A biosynthetic process
C2U32_RS16820	COG0488	(ABC) transporter
C2U32_RS16825	COG2900	Belongs to the SlyX family
C2U32_RS16835	COG1733	regulation of RNA biosynthetic process
C2U32_RS16860	COG0210	DNA helicase
C2U32_RS16865	COG0724	RNA recognition motif
C2U32_RS16885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2U32_RS16885	COG4651	solute:proton antiporter activity
C2U32_RS16910	COG0788	formyltetrahydrofolate deformylase activity
C2U32_RS17010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2U32_RS17010	COG2813	Specifically methylates the guanine in position
C2U32_RS17020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U32_RS17030	COG4774	siderophore transport
C2U32_RS17040	COG0740	serine-type endopeptidase activity
C2U32_RS17060	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C2U32_RS17060	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C2U32_RS17065	COG0280	phosphate acetyltransferase
C2U32_RS17065	COG0857	belongs to the CobB CobQ family
C2U32_RS17070	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2U32_RS17080	COG0800	Aldolase
C2U32_RS17090	COG3265	gluconokinase activity
C2U32_RS17095	COG1012	belongs to the aldehyde dehydrogenase family
C2U32_RS17105	COG2267	carboxylic ester hydrolase activity
C2U32_RS17120	COG0793	Belongs to the peptidase S41A family
C2U32_RS17155	COG1426	Protein conserved in bacteria
C2U32_RS17195	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2U32_RS17205	COG1162	GTPase activity
C2U32_RS17210	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C2U32_RS17225	COG1538	Outer membrane efflux protein
C2U32_RS17230	COG1136	(ABC) transporter
C2U32_RS17230	COG0577	efflux transmembrane transporter activity
C2U32_RS17235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U32_RS17260	COG0028	Belongs to the TPP enzyme family
C2U32_RS17265	COG0440	acetolactate synthase activity
C2U32_RS17280	COG2801	Transposase and inactivated derivatives
C2U32_RS17305	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C2U32_RS17320	COG0084	hydrolase, TatD family'
C2U32_RS17330	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2U32_RS17340	COG0583	DNA-binding transcription factor activity
C2U32_RS17350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U32_RS17355	COG2814	Major facilitator Superfamily
C2U32_RS17365	COG0697	spore germination
C2U32_RS17395	COG3622	Belongs to the hyi family
C2U32_RS17400	COG2084	Dehydrogenase
C2U32_RS17405	COG1024	Enoyl-CoA hydratase
C2U32_RS17410	COG5002	protein histidine kinase activity
C2U32_RS17410	COG2205	protein histidine kinase activity
C2U32_RS17410	COG0784	Response regulator, receiver
C2U32_RS17430	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U32_RS17440	COG3956	TIGRFAM MazG family protein
C2U32_RS17445	COG1555	photosystem II stabilization
C2U32_RS17450	COG0617	tRNA 3'-terminal CCA addition
C2U32_RS17455	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2U32_RS17475	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U32_RS17480	COG3028	Belongs to the UPF0307 family
C2U32_RS17485	COG0318	PFAM AMP-dependent synthetase and ligase
C2U32_RS17500	COG0625	glutathione transferase activity
C2U32_RS17505	COG1238	metal cluster binding
C2U32_RS17545	COG0072	phenylalanine-tRNA ligase activity
C2U32_RS17575	COG0248	Ppx GppA phosphatase
C2U32_RS17585	COG0037	tRNA processing
C2U32_RS17625	COG1764	response to oxidative stress
C2U32_RS17630	COG1846	Transcriptional regulator
C2U32_RS17640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U32_RS17700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2U32_RS17705	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2U32_RS17710	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2U32_RS17745	COG1214	PFAM Peptidase M22, glycoprotease
C2U32_RS17760	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C2U32_RS17770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2U32_RS17775	COG0561	phosphatase activity
C2U32_RS17785	COG2132	Multicopper oxidase
C2U32_RS17805	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2U32_RS17810	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C2U32_RS17815	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2U32_RS17845	COG1063	alcohol dehydrogenase
C2U32_RS17850	COG0583	DNA-binding transcription factor activity
C2U32_RS17855	COG1960	acyl-CoA dehydrogenase activity
C2U32_RS17860	COG2814	Major facilitator Superfamily
C2U32_RS17865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U32_RS17870	COG1309	transcriptional regulator
C2U32_RS17885	COG1053	succinate dehydrogenase
C2U32_RS17890	COG0583	DNA-binding transcription factor activity
C2U32_RS17910	COG0583	DNA-binding transcription factor activity
C2U32_RS17920	COG0583	DNA-binding transcription factor activity
C2U32_RS17935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U32_RS17980	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U32_RS18000	COG0745	RESPONSE REGULATOR receiver
C2U32_RS18040	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C2U32_RS18070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2U32_RS18075	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U32_RS18095	COG0583	DNA-binding transcription factor activity
C2U32_RS18115	COG0668	transmembrane transport
C2U32_RS18125	COG2081	HI0933 family
C2U32_RS18130	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C2U32_RS18160	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U32_RS18160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U32_RS18170	COG0489	protein tyrosine kinase activity
C2U32_RS18230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U32_RS18240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2U32_RS18255	COG0730	response to heat
C2U32_RS18265	COG1196	nuclear chromosome segregation
C2U32_RS18285	COG2223	nitrite transmembrane transporter activity
C2U32_RS18290	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C2U32_RS18295	COG1877	trehalose-phosphatase activity
C2U32_RS18300	COG0596	Alpha beta hydrolase
C2U32_RS18300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2U32_RS18300	COG2226	methyltransferase
C2U32_RS18315	COG4106	trans-aconitate 2-methyltransferase activity
C2U32_RS18340	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2U32_RS18345	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C2U32_RS18350	COG0009	L-threonylcarbamoyladenylate synthase
C2U32_RS18355	COG3101	peptidyl-lysine hydroxylation
C2U32_RS18360	COG1399	metal-binding, possibly nucleic acid-binding protein
C2U32_RS18385	COG1652	LysM domain
C2U32_RS18390	COG0352	thiamine-phosphate diphosphorylase activity
C2U32_RS18390	COG0351	phosphomethylpyrimidine kinase
C2U32_RS18390	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2U32_RS18400	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2U32_RS18430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2U32_RS18460	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C2U32_RS18475	COG0358	DNA primase activity
C2U32_RS18485	COG0564	pseudouridine synthase activity
C2U32_RS18510	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U32_RS18530	COG0583	DNA-binding transcription factor activity
C2U32_RS18535	COG0473	3-isopropylmalate dehydrogenase activity
C2U32_RS18545	COG0657	acetylesterase activity
C2U32_RS18555	COG1012	belongs to the aldehyde dehydrogenase family
C2U32_RS18575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U32_RS18575	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C2U32_RS18610	COG3328	transposase activity
C2U32_RS18685	COG0739	heme binding
C2U32_RS18685	COG1196	nuclear chromosome segregation
C2U32_RS18685	COG0741	lytic transglycosylase activity
C2U32_RS18700	COG0739	heme binding
C2U32_RS18700	COG0741	lytic transglycosylase activity
C2U32_RS18700	COG1196	nuclear chromosome segregation
C2U32_RS18725	COG1525	nuclease
C2U32_RS18755	COG2826	transposase and inactivated derivatives, IS30 family
C2U32_RS18785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U32_RS18855	COG1192	Involved in chromosome partitioning
C2U32_RS19040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U32_RS19060	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2U32_RS19145	COG3586	endonuclease activity
C2U32_RS19205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U32_RS19215	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C2U32_RS19240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U32_RS19245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2U32_RS19245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U32_RS19300	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U32_RS19300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U32_RS19315	COG0587	DNA-directed DNA polymerase activity
C2U32_RS19370	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C2U32_RS19405	COG3328	transposase activity
C2U32_RS19435	COG0358	DNA primase activity
C2U32_RS19490	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C2U32_RS19520	COG0477	Major facilitator Superfamily
C2U32_RS19525	COG0697	spore germination
C2U32_RS19535	COG3321	synthase
C2U32_RS19535	COG0604	alcohol dehydrogenase
C2U32_RS19540	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C2U32_RS19560	COG2801	Transposase and inactivated derivatives
C2U32_RS19580	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
C2U32_RS19615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2U32_RS19625	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
C2U32_RS19730	COG2816	NAD+ diphosphatase activity
C2U32_RS19735	COG3046	protein related to deoxyribodipyrimidine photolyase
C2U32_RS19750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U32_RS19775	COG1192	Involved in chromosome partitioning
C2U32_RS19880	COG0542	response to heat
C2U32_RS19915	COG0501	Belongs to the peptidase M48B family
C2U32_RS19920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U32_RS19935	COG2801	Transposase and inactivated derivatives
C2U32_RS20005	COG1252	NADH dehydrogenase
C2U32_RS20020	COG3791	Glutathione-dependent formaldehyde-activating
C2U32_RS20035	COG2918	glutathione biosynthetic process
C2U32_RS20060	COG1271	oxidase subunit
C2U32_RS20070	COG0556	nucleotide-excision repair
C2U32_RS20085	COG1074	ATP-dependent DNA helicase activity
C2U32_RS20090	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2U32_RS20095	COG0556	nucleotide-excision repair
C2U32_RS20135	COG0582	viral genome integration into host DNA
C2U32_RS20150	COG2130	NADP-dependent
C2U32_RS20155	COG1309	transcriptional regulator
C2U32_RS20165	COG1902	pentaerythritol trinitrate reductase activity
C2U32_RS20175	COG1979	alcohol dehydrogenase