locus-tag	class	description
L2Z42_RS00010	COG0302	gtp cyclohydrolase
L2Z42_RS00020	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2Z42_RS00050	COG0308	aminopeptidase N
L2Z42_RS00055	COG0512	Glutamine amidotransferase of anthranilate synthase
L2Z42_RS00070	COG0174	glutamine synthetase
L2Z42_RS00080	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Z42_RS00115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Z42_RS00120	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2Z42_RS00125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z42_RS00145	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z42_RS00150	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Z42_RS00155	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Z42_RS00170	COG1960	acyl-CoA dehydrogenase activity
L2Z42_RS00175	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z42_RS00180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z42_RS00190	COG2223	nitrite transmembrane transporter activity
L2Z42_RS00200	COG0024	Methionine aminopeptidase
L2Z42_RS00205	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Z42_RS00220	COG2207	Transcriptional regulator
L2Z42_RS00245	COG2951	lytic endotransglycosylase activity
L2Z42_RS00250	COG0772	Belongs to the SEDS family
L2Z42_RS00265	COG0842	Transport permease protein
L2Z42_RS00270	COG1131	(ABC) transporter
L2Z42_RS00315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z42_RS00330	COG4215	(ABC) transporter
L2Z42_RS00335	COG4160	amino acid transport
L2Z42_RS00340	COG4598	ABC transporter
L2Z42_RS00350	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z42_RS00355	COG0826	peptidase U32
L2Z42_RS00360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z42_RS00375	COG1720	tRNA m6t6A37 methyltransferase activity
L2Z42_RS00385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Z42_RS00400	COG0642	Histidine kinase
L2Z42_RS00410	COG0494	nUDIX hydrolase
L2Z42_RS00420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Z42_RS00425	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Z42_RS00430	COG3139	Protein of unknown function (DUF1315)
L2Z42_RS00435	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Z42_RS00440	COG1301	dicarboxylic acid transport
L2Z42_RS00445	COG1960	acyl-CoA dehydrogenase activity
L2Z42_RS00450	COG2819	hydrolase of the alpha beta superfamily
L2Z42_RS00460	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Z42_RS00470	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2Z42_RS00490	COG1690	Belongs to the RtcB family
L2Z42_RS00495	COG1234	tRNA 3'-trailer cleavage
L2Z42_RS00500	COG4650	regulator
L2Z42_RS00530	COG2363	Small membrane protein
L2Z42_RS00555	COG0513	Belongs to the DEAD box helicase family
L2Z42_RS00565	COG0778	Nitroreductase
L2Z42_RS00595	COG1286	toxin biosynthetic process
L2Z42_RS00620	COG4783	chaperone-mediated protein folding
L2Z42_RS00625	COG1610	YqeY-like protein
L2Z42_RS00655	COG0515	serine threonine protein kinase
L2Z42_RS00655	COG2815	serine threonine protein kinase
L2Z42_RS00725	COG3111	PFAM Bacterial OB fold (BOF) protein
L2Z42_RS00750	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Z42_RS00755	COG0786	glutamate:sodium symporter activity
L2Z42_RS00765	COG2186	Transcriptional regulator
L2Z42_RS00815	COG0477	Major facilitator Superfamily
L2Z42_RS00820	COG1051	belongs to the nudix hydrolase family
L2Z42_RS00850	COG2995	paraquat-inducible protein a
L2Z42_RS00855	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Z42_RS00855	COG3008	intermembrane lipid transfer
L2Z42_RS00870	COG1794	racemase activity, acting on amino acids and derivatives
L2Z42_RS00900	COG1301	dicarboxylic acid transport
L2Z42_RS00910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z42_RS00915	COG2011	ABC-type metal ion transport system permease component
L2Z42_RS00920	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z42_RS00925	COG1464	Belongs to the NlpA lipoprotein family
L2Z42_RS00930	COG0151	Belongs to the GarS family
L2Z42_RS00935	COG0138	bifunctional purine biosynthesis protein purh
L2Z42_RS00940	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Z42_RS00970	COG2308	Evidence 4 Homologs of previously reported genes of
L2Z42_RS00980	COG1305	Transglutaminase-like
L2Z42_RS00990	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Z42_RS00995	COG0305	Participates in initiation and elongation during chromosome replication
L2Z42_RS01020	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2Z42_RS01030	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Z42_RS01035	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Z42_RS01060	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z42_RS01060	COG0726	polysaccharide deacetylase
L2Z42_RS01065	COG1215	transferase activity, transferring glycosyl groups
L2Z42_RS01070	COG3658	cytochrome
L2Z42_RS01080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z42_RS01095	COG0583	DNA-binding transcription factor activity
L2Z42_RS01125	COG1960	acyl-CoA dehydrogenase activity
L2Z42_RS01130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z42_RS01135	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z42_RS01150	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L2Z42_RS01160	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2Z42_RS01165	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2Z42_RS01170	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
L2Z42_RS01175	COG2205	protein histidine kinase activity
L2Z42_RS01180	COG0745	RESPONSE REGULATOR receiver
L2Z42_RS01205	COG0729	surface antigen
L2Z42_RS01230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z42_RS01235	COG2814	Major facilitator Superfamily
L2Z42_RS01250	COG0583	DNA-binding transcription factor activity
L2Z42_RS01265	COG1187	pseudouridine synthase activity
L2Z42_RS01285	COG0802	atpase or kinase
L2Z42_RS01290	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Z42_RS01300	COG1923	regulation of RNA biosynthetic process
L2Z42_RS01305	COG0697	spore germination
L2Z42_RS01330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z42_RS01335	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z42_RS01335	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z42_RS01340	COG4302	ethanolamine ammonia-lyase activity
L2Z42_RS01345	COG4303	Ethanolamine ammonia lyase large subunit
L2Z42_RS01350	COG0531	amino acid
L2Z42_RS01370	COG1454	alcohol dehydrogenase
L2Z42_RS01375	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z42_RS01400	COG0308	aminopeptidase N
L2Z42_RS01440	COG1605	Chorismate mutase
L2Z42_RS01460	COG1309	transcriptional regulator
L2Z42_RS01470	COG0668	transmembrane transport
L2Z42_RS01500	COG4773	Receptor
L2Z42_RS01520	COG0488	(ABC) transporter
L2Z42_RS01525	COG0589	response to stress
L2Z42_RS01545	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Z42_RS01555	COG3135	benzoate transporter
L2Z42_RS01560	COG1522	sequence-specific DNA binding
L2Z42_RS01570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z42_RS01575	COG0583	DNA-binding transcription factor activity
L2Z42_RS01585	COG0183	Belongs to the thiolase family
L2Z42_RS01595	COG2030	dehydratase
L2Z42_RS01600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z42_RS01615	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z42_RS01625	COG0824	Thioesterase
L2Z42_RS01630	COG1454	alcohol dehydrogenase
L2Z42_RS01640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Z42_RS01660	COG0069	glutamate synthase activity
L2Z42_RS01805	COG3617	BRO family, N-terminal domain
L2Z42_RS01845	COG5410	chromosome segregation
L2Z42_RS01950	COG1598	PFAM Uncharacterised protein family UPF0150
L2Z42_RS02020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z42_RS02035	COG2814	Major facilitator Superfamily
L2Z42_RS02050	COG0511	ligase activity, forming carbon-carbon bonds
L2Z42_RS02070	COG1116	anion transmembrane transporter activity
L2Z42_RS02070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z42_RS02075	COG0745	RESPONSE REGULATOR receiver
L2Z42_RS02085	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z42_RS02085	COG2146	nitrite reductase [NAD(P)H] activity
L2Z42_RS02090	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z42_RS02095	COG0243	molybdopterin cofactor binding
L2Z42_RS02105	COG0243	molybdopterin cofactor binding
L2Z42_RS02110	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Z42_RS02125	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Z42_RS02125	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Z42_RS02130	COG0303	'Molybdopterin
L2Z42_RS02140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z42_RS02145	COG0697	spore germination
L2Z42_RS02165	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Z42_RS02170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z42_RS02225	COG2204	response regulator
L2Z42_RS02230	COG3852	Histidine kinase
L2Z42_RS02255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Z42_RS02260	COG0575	Belongs to the CDS family
L2Z42_RS02275	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z42_RS02295	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z42_RS02310	COG2137	regulation of response to DNA damage stimulus
L2Z42_RS02320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Z42_RS02325	COG1011	Hydrolase
L2Z42_RS02350	COG1522	sequence-specific DNA binding
L2Z42_RS02360	COG1113	amino acid transport
L2Z42_RS02380	COG0659	secondary active sulfate transmembrane transporter activity
L2Z42_RS02385	COG2135	peptidase activity
L2Z42_RS02400	COG3300	MHYT domain
L2Z42_RS02400	COG5001	Diguanylate cyclase
L2Z42_RS02415	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2Z42_RS02415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z42_RS02415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z42_RS02420	COG1105	Belongs to the carbohydrate kinase PfkB family
L2Z42_RS02425	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Z42_RS02425	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z42_RS02455	COG0024	Methionine aminopeptidase
L2Z42_RS02460	COG0583	DNA-binding transcription factor activity
L2Z42_RS02470	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Z42_RS02475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z42_RS02480	COG0517	IMP dehydrogenase activity
L2Z42_RS02480	COG0516	GMP reductase activity
L2Z42_RS02505	COG0552	protein localization to endoplasmic reticulum
L2Z42_RS02515	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2Z42_RS02530	COG4890	Cyd operon protein YbgT
L2Z42_RS02535	COG1294	oxidase, subunit
L2Z42_RS02550	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2Z42_RS02560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Z42_RS02565	COG4774	siderophore transport
L2Z42_RS02580	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Z42_RS02585	COG0569	domain protein
L2Z42_RS02590	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z42_RS02620	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Z42_RS02625	COG0542	response to heat
L2Z42_RS02650	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z42_RS02650	COG1902	pentaerythritol trinitrate reductase activity
L2Z42_RS02695	COG2323	membrane
L2Z42_RS02700	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Z42_RS02710	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z42_RS02715	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z42_RS02720	COG0183	Belongs to the thiolase family
L2Z42_RS02725	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Z42_RS02730	COG0596	Alpha beta hydrolase
L2Z42_RS02735	COG2271	Major facilitator Superfamily
L2Z42_RS02740	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z42_RS02745	COG3485	protocatechuate 3,4-dioxygenase
L2Z42_RS02750	COG3485	protocatechuate 3,4-dioxygenase
L2Z42_RS02755	COG0710	3-dehydroquinate dehydratase activity
L2Z42_RS02760	COG3420	alginic acid biosynthetic process
L2Z42_RS02765	COG3659	wide pore channel activity
L2Z42_RS02770	COG4993	Dehydrogenase
L2Z42_RS02780	COG2391	methyltransferase activity
L2Z42_RS02795	COG1414	Transcriptional regulator
L2Z42_RS02800	COG0583	DNA-binding transcription factor activity
L2Z42_RS02805	COG1960	acyl-CoA dehydrogenase activity
L2Z42_RS02830	COG2814	Major facilitator Superfamily
L2Z42_RS02840	COG0154	amidase activity
L2Z42_RS02860	COG4638	Rieske (2fe-2S)
L2Z42_RS02870	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z42_RS02880	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z42_RS02890	COG3733	amine oxidase
L2Z42_RS02900	COG1012	belongs to the aldehyde dehydrogenase family
L2Z42_RS02910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z42_RS02915	COG0183	Belongs to the thiolase family
L2Z42_RS02920	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z42_RS02925	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z42_RS02935	COG4829	muconolactone delta-isomerase
L2Z42_RS02940	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z42_RS02945	COG0583	DNA-binding transcription factor activity
L2Z42_RS02955	COG2186	Transcriptional regulator
L2Z42_RS02975	COG1012	belongs to the aldehyde dehydrogenase family
L2Z42_RS02990	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z42_RS02990	COG1902	pentaerythritol trinitrate reductase activity
L2Z42_RS03000	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L2Z42_RS03010	COG0789	Transcriptional regulator
L2Z42_RS03035	COG1309	transcriptional regulator
L2Z42_RS03040	COG0583	DNA-binding transcription factor activity
L2Z42_RS03045	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z42_RS03050	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z42_RS03055	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z42_RS03065	COG1960	acyl-CoA dehydrogenase activity
L2Z42_RS03075	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z42_RS03150	COG2188	Transcriptional regulator
L2Z42_RS03165	COG0583	DNA-binding transcription factor activity
L2Z42_RS03180	COG1566	PFAM secretion protein HlyD family protein
L2Z42_RS03195	COG1012	belongs to the aldehyde dehydrogenase family
L2Z42_RS03200	COG0129	dihydroxy-acid dehydratase activity
L2Z42_RS03210	COG0583	DNA-binding transcription factor activity
L2Z42_RS03215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z42_RS03225	COG2084	Dehydrogenase
L2Z42_RS03230	COG2207	Transcriptional regulator
L2Z42_RS03235	COG1064	alcohol dehydrogenase
L2Z42_RS03245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z42_RS03250	COG1120	ATPase activity
L2Z42_RS03345	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2Z42_RS03380	COG2856	Zn peptidase
L2Z42_RS03435	COG2207	Transcriptional regulator
L2Z42_RS03450	COG2205	protein histidine kinase activity
L2Z42_RS03455	COG0745	RESPONSE REGULATOR receiver
L2Z42_RS03460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z42_RS03465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z42_RS03545	COG3539	Fimbrial protein
L2Z42_RS03570	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L2Z42_RS03580	COG0753	catalase activity
L2Z42_RS03595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z42_RS03655	COG1535	isochorismatase
L2Z42_RS03655	COG3433	isochorismatase activity
L2Z42_RS03660	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z42_RS03665	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2Z42_RS03670	COG4149	molybdate abc transporter
L2Z42_RS03675	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2Z42_RS03685	COG4638	Rieske (2fe-2S)
L2Z42_RS03690	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z42_RS03695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z42_RS03695	COG0543	2 iron, 2 sulfur cluster binding
L2Z42_RS03710	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z42_RS03720	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z42_RS03735	COG2207	Transcriptional regulator
L2Z42_RS03740	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z42_RS03745	COG2610	gluconate transmembrane transporter activity
L2Z42_RS03755	COG1309	transcriptional regulator
L2Z42_RS03780	COG0583	DNA-binding transcription factor activity
L2Z42_RS03795	COG2031	fatty acid transporter
L2Z42_RS03800	COG0183	Belongs to the thiolase family
L2Z42_RS03805	COG0583	DNA-binding transcription factor activity
L2Z42_RS03810	COG0583	DNA-binding transcription factor activity
L2Z42_RS03825	COG1027	Aspartate ammonia-lyase
L2Z42_RS03835	COG0477	Major facilitator Superfamily
L2Z42_RS03855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z42_RS03860	COG4521	taurine ABC transporter
L2Z42_RS03875	COG2188	Transcriptional regulator
L2Z42_RS03885	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Z42_RS03890	COG1733	regulation of RNA biosynthetic process
L2Z42_RS03895	COG3708	Transcriptional regulator
L2Z42_RS03895	COG2207	Transcriptional regulator
L2Z42_RS03910	COG0730	response to heat
L2Z42_RS03925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z42_RS03925	COG3453	Protein conserved in bacteria
L2Z42_RS03935	COG3781	membrane
L2Z42_RS03940	COG1063	alcohol dehydrogenase
L2Z42_RS03950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z42_RS03955	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z42_RS03960	COG0022	dehydrogenase e1 component
L2Z42_RS03965	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2Z42_RS03970	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z42_RS03985	COG3706	GGDEF domain
L2Z42_RS04000	COG0133	tryptophan synthase activity
L2Z42_RS04010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z42_RS04040	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
L2Z42_RS04045	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Z42_RS04070	COG2226	methyltransferase
L2Z42_RS04125	COG0842	Transport permease protein
L2Z42_RS04130	COG0842	Transport permease protein
L2Z42_RS04135	COG1131	(ABC) transporter
L2Z42_RS04150	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z42_RS04155	COG4773	Receptor
L2Z42_RS04175	COG0730	response to heat
L2Z42_RS04180	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Z42_RS04195	COG0406	alpha-ribazole phosphatase activity
L2Z42_RS04200	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2Z42_RS04215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z42_RS04255	COG4264	IucA IucC family
L2Z42_RS04260	COG4264	IucA IucC family
L2Z42_RS04265	COG2814	Major facilitator Superfamily
L2Z42_RS04280	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Z42_RS04295	COG1960	acyl-CoA dehydrogenase activity
L2Z42_RS04300	COG1960	acyl-CoA dehydrogenase activity
L2Z42_RS04305	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z42_RS04310	COG2207	Transcriptional regulator
L2Z42_RS04315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z42_RS04320	COG0776	regulation of translation
L2Z42_RS04345	COG0822	iron-sulfur transferase activity
L2Z42_RS04350	COG0316	Belongs to the HesB IscA family
L2Z42_RS04380	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Z42_RS04400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z42_RS04405	COG0702	epimerase
L2Z42_RS04440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Z42_RS04450	COG0339	signal peptide processing
L2Z42_RS04500	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Z42_RS04620	COG4695	Portal protein
L2Z42_RS04785	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Z42_RS04815	COG0776	regulation of translation
L2Z42_RS04880	COG0084	hydrolase, TatD family'
L2Z42_RS04900	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Z42_RS04905	COG1132	(ABC) transporter
L2Z42_RS04915	COG0811	peptide transport
L2Z42_RS04920	COG1475	DNA binding
L2Z42_RS04925	COG1192	Involved in chromosome partitioning
L2Z42_RS04935	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z42_RS04950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z42_RS04955	COG0191	fructose-bisphosphate aldolase activity
L2Z42_RS04975	COG0424	maF-like protein
L2Z42_RS04980	COG2850	peptidyl-arginine hydroxylation
L2Z42_RS04990	COG0640	Transcriptional regulator
L2Z42_RS05000	COG3619	membrane
L2Z42_RS05005	COG3122	Protein conserved in bacteria
L2Z42_RS05010	COG1132	(ABC) transporter
L2Z42_RS05030	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Z42_RS05035	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z42_RS05045	COG0506	proline dehydrogenase activity
L2Z42_RS05045	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z42_RS05045	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z42_RS05050	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2Z42_RS05065	COG3698	Phosphodiester glycosidase
L2Z42_RS05075	COG2353	YceI-like domain
L2Z42_RS05085	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Z42_RS05130	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Z42_RS05130	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Z42_RS05155	COG3539	Fimbrial protein
L2Z42_RS05160	COG3121	Chaperone
L2Z42_RS05185	COG0697	spore germination
L2Z42_RS05195	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z42_RS05205	COG0583	DNA-binding transcription factor activity
L2Z42_RS05225	COG1309	transcriptional regulator
L2Z42_RS05240	COG1522	sequence-specific DNA binding
L2Z42_RS05250	COG1126	abc transporter atp-binding protein
L2Z42_RS05255	COG0765	amino acid transport
L2Z42_RS05260	COG0765	amino acid transport
L2Z42_RS05290	COG1464	Belongs to the NlpA lipoprotein family
L2Z42_RS05300	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z42_RS05305	COG2011	ABC-type metal ion transport system permease component
L2Z42_RS05310	COG0012	GTP binding
L2Z42_RS05335	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z42_RS05375	COG0386	Belongs to the glutathione peroxidase family
L2Z42_RS05385	COG0436	Aminotransferase
L2Z42_RS05390	COG1301	dicarboxylic acid transport
L2Z42_RS05425	COG3634	alkyl hydroperoxide reductase activity
L2Z42_RS05440	COG0583	DNA-binding transcription factor activity
L2Z42_RS05445	COG0798	PFAM Bile acid sodium symporter
L2Z42_RS05450	COG0640	Transcriptional regulator
L2Z42_RS05465	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L2Z42_RS05475	COG0583	DNA-binding transcription factor activity
L2Z42_RS05485	COG1953	Uracil, thiamine, allantoin
L2Z42_RS05495	COG2175	clavaminate synthase activity
L2Z42_RS05500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z42_RS05505	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2Z42_RS05510	COG4521	taurine ABC transporter
L2Z42_RS05520	COG0477	Major facilitator Superfamily
L2Z42_RS05540	COG1271	oxidase subunit
L2Z42_RS05545	COG1294	oxidase, subunit
L2Z42_RS05555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z42_RS05575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Z42_RS05595	COG3052	prosthetic group binding
L2Z42_RS05600	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2Z42_RS05610	COG0583	DNA-binding transcription factor activity
L2Z42_RS05620	COG2814	Major facilitator Superfamily
L2Z42_RS05635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z42_RS05640	COG1346	cytolysis
L2Z42_RS05650	COG0583	DNA-binding transcription factor activity
L2Z42_RS05655	COG0625	glutathione transferase activity
L2Z42_RS05660	COG0625	glutathione transferase activity
L2Z42_RS05665	COG0583	DNA-binding transcription factor activity
L2Z42_RS05680	COG1045	serine acetyltransferase
L2Z42_RS05685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z42_RS05690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2Z42_RS05715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z42_RS05720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z42_RS05730	COG0765	amino acid transport
L2Z42_RS05735	COG0765	amino acid transport
L2Z42_RS05755	COG2205	protein histidine kinase activity
L2Z42_RS05755	COG0784	Response regulator, receiver
L2Z42_RS05800	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z42_RS05850	COG0583	DNA-binding transcription factor activity
L2Z42_RS05870	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z42_RS05875	COG1309	transcriptional regulator
L2Z42_RS05880	COG1960	acyl-CoA dehydrogenase activity
L2Z42_RS05885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z42_RS05890	COG1024	Enoyl-CoA hydratase
L2Z42_RS05895	COG4770	biotin carboxylase activity
L2Z42_RS05905	COG0583	DNA-binding transcription factor activity
L2Z42_RS05925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z42_RS05930	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Z42_RS05945	COG3842	ATPase activity
L2Z42_RS05950	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Z42_RS05965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z42_RS05970	COG1414	Transcriptional regulator
L2Z42_RS05980	COG0583	DNA-binding transcription factor activity
L2Z42_RS05985	COG3038	cytochrome b561
L2Z42_RS05990	COG0753	catalase activity
L2Z42_RS06025	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z42_RS06035	COG3327	negative regulation of DNA-templated transcription, initiation
L2Z42_RS06040	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L2Z42_RS06045	COG0183	Belongs to the thiolase family
L2Z42_RS06050	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z42_RS06055	COG1024	Enoyl-CoA hydratase
L2Z42_RS06060	COG1024	Enoyl-CoA hydratase
L2Z42_RS06065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z42_RS06070	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Z42_RS06075	COG3396	Phenylacetate-CoA oxygenase
L2Z42_RS06080	COG3460	Phenylacetate-CoA oxygenase
L2Z42_RS06085	COG3396	Phenylacetate-CoA oxygenase
L2Z42_RS06090	COG1012	belongs to the aldehyde dehydrogenase family
L2Z42_RS06090	COG2030	dehydratase
L2Z42_RS06095	COG1760	l-serine dehydratase
L2Z42_RS06100	COG0531	amino acid
L2Z42_RS06105	COG1012	belongs to the aldehyde dehydrogenase family
L2Z42_RS06130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z42_RS06150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z42_RS06160	COG0789	Transcriptional regulator
L2Z42_RS06170	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2Z42_RS06185	COG2807	transmembrane transport
L2Z42_RS06190	COG0590	tRNA wobble adenosine to inosine editing
L2Z42_RS06300	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z42_RS06325	COG1116	anion transmembrane transporter activity
L2Z42_RS06330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z42_RS06340	COG0864	Transcriptional regulator
L2Z42_RS06360	COG1733	regulation of RNA biosynthetic process
L2Z42_RS06365	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z42_RS06370	COG0439	Biotin carboxylase
L2Z42_RS06385	COG1063	alcohol dehydrogenase
L2Z42_RS06395	COG1309	transcriptional regulator
L2Z42_RS06405	COG0038	chloride channel
L2Z42_RS06410	COG4770	biotin carboxylase activity
L2Z42_RS06430	COG1914	H( )-stimulated, divalent metal cation uptake system
L2Z42_RS06435	COG0583	DNA-binding transcription factor activity
L2Z42_RS06470	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z42_RS06490	COG2814	Major facilitator Superfamily
L2Z42_RS06510	COG0598	Magnesium transport protein CorA
L2Z42_RS06515	COG1560	Kdo2-lipid A biosynthetic process
L2Z42_RS06530	COG1522	sequence-specific DNA binding
L2Z42_RS06545	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2Z42_RS06555	COG4122	O-methyltransferase activity
L2Z42_RS06585	COG1538	Outer membrane efflux protein
L2Z42_RS06590	COG1137	ATPase activity
L2Z42_RS06595	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2Z42_RS06605	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Z42_RS06610	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L2Z42_RS06610	COG0517	IMP dehydrogenase activity
L2Z42_RS06645	COG2814	Major facilitator Superfamily
L2Z42_RS06680	COG1278	Cold shock
L2Z42_RS06685	COG1280	lysine exporter protein (LysE YggA)
L2Z42_RS06715	COG1570	exodeoxyribonuclease VII activity
L2Z42_RS06765	COG0583	DNA-binding transcription factor activity
L2Z42_RS06770	COG4638	Rieske (2fe-2S)
L2Z42_RS06775	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z42_RS06780	COG0543	2 iron, 2 sulfur cluster binding
L2Z42_RS06780	COG0633	Ferredoxin
L2Z42_RS06785	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z42_RS06790	COG3135	benzoate transporter
L2Z42_RS06795	COG2814	Major facilitator Superfamily
L2Z42_RS06810	COG1643	Atp-dependent helicase
L2Z42_RS06815	COG0450	alkyl hydroperoxide reductase
L2Z42_RS06825	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2Z42_RS06835	COG3634	alkyl hydroperoxide reductase activity
L2Z42_RS06855	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2Z42_RS06860	COG0625	glutathione transferase activity
L2Z42_RS06870	COG2885	chlorophyll binding
L2Z42_RS06905	COG0542	response to heat
L2Z42_RS06920	COG1765	OsmC-like protein
L2Z42_RS06935	COG0667	Aldo Keto reductase
L2Z42_RS06950	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Z42_RS06970	COG0582	viral genome integration into host DNA
L2Z42_RS07105	COG3566	protein conserved in bacteria
L2Z42_RS07125	COG3567	Phage-associated protein, HI1409 family
L2Z42_RS07130	COG5410	chromosome segregation
L2Z42_RS07205	COG4197	protein conserved in bacteria, prophage-related
L2Z42_RS07210	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Z42_RS07260	COG0527	aspartate kinase activity
L2Z42_RS07270	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2Z42_RS07280	COG3038	cytochrome b561
L2Z42_RS07285	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2Z42_RS07290	COG2252	PERMEase
L2Z42_RS07300	COG2072	flavoprotein involved in K transport
L2Z42_RS07315	COG1741	Belongs to the pirin family
L2Z42_RS07330	COG0300	oxidoreductase activity
L2Z42_RS07335	COG2072	flavoprotein involved in K transport
L2Z42_RS07340	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
L2Z42_RS07385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z42_RS07400	COG2814	Major facilitator Superfamily
L2Z42_RS07405	COG1024	Enoyl-CoA hydratase
L2Z42_RS07410	COG1012	belongs to the aldehyde dehydrogenase family
L2Z42_RS07420	COG1960	acyl-CoA dehydrogenase activity
L2Z42_RS07445	COG2186	Transcriptional regulator
L2Z42_RS07450	COG1012	belongs to the aldehyde dehydrogenase family
L2Z42_RS07460	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z42_RS07465	COG2271	Major facilitator Superfamily
L2Z42_RS07470	COG2721	sulfolactate sulfo-lyase activity
L2Z42_RS07475	COG0697	spore germination
L2Z42_RS07505	COG1113	amino acid transport
L2Z42_RS07525	COG1012	belongs to the aldehyde dehydrogenase family
L2Z42_RS07545	COG0531	amino acid
L2Z42_RS07555	COG1113	amino acid transport
L2Z42_RS07600	COG0583	DNA-binding transcription factor activity
L2Z42_RS07610	COG0251	oxidation-reduction process
L2Z42_RS07655	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z42_RS07655	COG1902	pentaerythritol trinitrate reductase activity
L2Z42_RS07670	COG3706	GGDEF domain
L2Z42_RS07670	COG4251	negative regulation of phosphorylation
L2Z42_RS07670	COG2203	Gaf domain
L2Z42_RS07670	COG5001	Diguanylate cyclase
L2Z42_RS07680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z42_RS07700	COG4172	Belongs to the ABC transporter superfamily
L2Z42_RS07705	COG4239	(ABC) transporter, permease
L2Z42_RS07710	COG4174	ABC transporter (Permease)
L2Z42_RS07720	COG0741	lytic transglycosylase activity
L2Z42_RS07720	COG1388	LysM domain
L2Z42_RS07720	COG0741	lytic transglycosylase activity
L2Z42_RS07720	COG1388	LysM domain
L2Z42_RS07725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z42_RS07765	COG0583	DNA-binding transcription factor activity
L2Z42_RS07770	COG1279	arginine transmembrane transporter activity
L2Z42_RS07790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z42_RS07795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z42_RS07800	COG0006	proline dipeptidase activity
L2Z42_RS07840	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2Z42_RS07865	COG3384	dioxygenase
L2Z42_RS07875	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z42_RS07880	COG2878	Part of a membrane complex involved in electron transport
L2Z42_RS07885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Z42_RS07910	COG0768	penicillin binding
L2Z42_RS07915	COG0742	ribosomal rna small subunit methyltransferase
L2Z42_RS07930	COG0830	nickel cation binding
L2Z42_RS07940	COG0804	urea catabolic process
L2Z42_RS07985	COG1253	flavin adenine dinucleotide binding
L2Z42_RS07990	COG2851	Citrate transporter
L2Z42_RS08040	COG1773	rubredoxin
L2Z42_RS08045	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z42_RS08055	COG0583	DNA-binding transcription factor activity
L2Z42_RS08085	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Z42_RS08090	COG4181	ATPase activity
L2Z42_RS08135	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z42_RS08155	COG0306	phosphate transporter
L2Z42_RS08170	COG3958	Transketolase
L2Z42_RS08175	COG3959	Transketolase, thiamine diphosphate binding domain
L2Z42_RS08180	COG2271	Major facilitator Superfamily
L2Z42_RS08185	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z42_RS08190	COG0583	DNA-binding transcription factor activity
L2Z42_RS08210	COG2223	nitrite transmembrane transporter activity
L2Z42_RS08215	COG2207	Transcriptional regulator
L2Z42_RS08220	COG2066	Belongs to the glutaminase family
L2Z42_RS08225	COG0242	peptide deformylase activity
L2Z42_RS08230	COG0477	Major facilitator Superfamily
L2Z42_RS08240	COG0028	Belongs to the TPP enzyme family
L2Z42_RS08255	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z42_RS08260	COG2267	carboxylic ester hydrolase activity
L2Z42_RS08270	COG2271	Major facilitator Superfamily
L2Z42_RS08275	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z42_RS08285	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z42_RS08305	COG1414	Transcriptional regulator
L2Z42_RS08320	COG1024	Enoyl-CoA hydratase
L2Z42_RS08330	COG1215	transferase activity, transferring glycosyl groups
L2Z42_RS08335	COG0726	polysaccharide deacetylase
L2Z42_RS08335	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z42_RS08345	COG4681	YaeQ
L2Z42_RS08355	COG0523	cobalamin synthesis protein
L2Z42_RS08365	COG1607	acyl-coa hydrolase
L2Z42_RS08375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z42_RS08380	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z42_RS08385	COG1309	transcriptional regulator
L2Z42_RS08410	COG2040	homocysteine
L2Z42_RS08415	COG0531	amino acid
L2Z42_RS08440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z42_RS08445	COG0477	Major facilitator Superfamily
L2Z42_RS08485	COG0405	Gamma-glutamyltransferase
L2Z42_RS08490	COG2814	Major facilitator Superfamily
L2Z42_RS08500	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z42_RS08515	COG1090	epimerase
L2Z42_RS08535	COG0420	3'-5' exonuclease activity
L2Z42_RS08560	COG0735	belongs to the Fur family
L2Z42_RS08565	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z42_RS08585	COG0121	glutamine amidotransferase
L2Z42_RS08600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z42_RS08610	COG0210	DNA helicase
L2Z42_RS08615	COG2885	chlorophyll binding
L2Z42_RS08620	COG0204	Acyl-transferase
L2Z42_RS08635	COG2894	cell division
L2Z42_RS08650	COG1280	lysine exporter protein (LysE YggA)
L2Z42_RS08655	COG1674	ftsk spoiiie
L2Z42_RS08655	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Z42_RS08660	COG0492	ferredoxin-NADP+ reductase activity
L2Z42_RS08665	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Z42_RS08675	COG0456	acetyltransferase
L2Z42_RS08720	COG1981	membrane
L2Z42_RS08735	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Z42_RS08735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z42_RS08755	COG1012	belongs to the aldehyde dehydrogenase family
L2Z42_RS08765	COG0657	acetylesterase activity
L2Z42_RS08775	COG0473	3-isopropylmalate dehydrogenase activity
L2Z42_RS08780	COG0583	DNA-binding transcription factor activity
L2Z42_RS08800	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z42_RS08825	COG0564	pseudouridine synthase activity
L2Z42_RS08835	COG0358	DNA primase activity
L2Z42_RS08850	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Z42_RS08880	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z42_RS08910	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2Z42_RS08920	COG0352	thiamine-phosphate diphosphorylase activity
L2Z42_RS08920	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z42_RS08920	COG0351	phosphomethylpyrimidine kinase
L2Z42_RS08925	COG1652	LysM domain
L2Z42_RS08950	COG1399	metal-binding, possibly nucleic acid-binding protein
L2Z42_RS08955	COG3101	peptidyl-lysine hydroxylation
L2Z42_RS08960	COG0009	L-threonylcarbamoyladenylate synthase
L2Z42_RS08965	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2Z42_RS08970	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Z42_RS08985	COG4106	trans-aconitate 2-methyltransferase activity
L2Z42_RS09000	COG0596	Alpha beta hydrolase
L2Z42_RS09000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z42_RS09000	COG2226	methyltransferase
L2Z42_RS09005	COG1877	trehalose-phosphatase activity
L2Z42_RS09010	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2Z42_RS09015	COG2223	nitrite transmembrane transporter activity
L2Z42_RS09035	COG1196	nuclear chromosome segregation
L2Z42_RS09045	COG0730	response to heat
L2Z42_RS09060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Z42_RS09070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z42_RS09120	COG0489	protein tyrosine kinase activity
L2Z42_RS09130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z42_RS09130	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z42_RS09160	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z42_RS09165	COG2081	HI0933 family
L2Z42_RS09175	COG0668	transmembrane transport
L2Z42_RS09195	COG0583	DNA-binding transcription factor activity
L2Z42_RS09220	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Z42_RS09225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z42_RS09255	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Z42_RS09295	COG0745	RESPONSE REGULATOR receiver
L2Z42_RS09315	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Z42_RS09370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z42_RS09385	COG0583	DNA-binding transcription factor activity
L2Z42_RS09415	COG0583	DNA-binding transcription factor activity
L2Z42_RS09430	COG0583	DNA-binding transcription factor activity
L2Z42_RS09435	COG1053	succinate dehydrogenase
L2Z42_RS09445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z42_RS09450	COG2814	Major facilitator Superfamily
L2Z42_RS09455	COG1960	acyl-CoA dehydrogenase activity
L2Z42_RS09460	COG0583	DNA-binding transcription factor activity
L2Z42_RS09465	COG1063	alcohol dehydrogenase
L2Z42_RS09495	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Z42_RS09500	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Z42_RS09505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z42_RS09525	COG2132	Multicopper oxidase
L2Z42_RS09535	COG0561	phosphatase activity
L2Z42_RS09540	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z42_RS09565	COG1214	PFAM Peptidase M22, glycoprotease
L2Z42_RS09615	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L2Z42_RS09625	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Z42_RS09630	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Z42_RS09635	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2Z42_RS09695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z42_RS09705	COG1846	Transcriptional regulator
L2Z42_RS09710	COG1764	response to oxidative stress
L2Z42_RS09750	COG0037	tRNA processing
L2Z42_RS09760	COG0248	Ppx GppA phosphatase
L2Z42_RS09790	COG0072	phenylalanine-tRNA ligase activity
L2Z42_RS09835	COG1238	metal cluster binding
L2Z42_RS09840	COG0625	glutathione transferase activity
L2Z42_RS09855	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z42_RS09860	COG3028	Belongs to the UPF0307 family
L2Z42_RS09865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z42_RS09885	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Z42_RS09890	COG0617	tRNA 3'-terminal CCA addition
L2Z42_RS09895	COG1555	photosystem II stabilization
L2Z42_RS09900	COG3956	TIGRFAM MazG family protein
L2Z42_RS09910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z42_RS09930	COG0784	Response regulator, receiver
L2Z42_RS09930	COG2205	protein histidine kinase activity
L2Z42_RS09930	COG5002	protein histidine kinase activity
L2Z42_RS09935	COG1024	Enoyl-CoA hydratase
L2Z42_RS09940	COG2084	Dehydrogenase
L2Z42_RS09945	COG3622	Belongs to the hyi family
L2Z42_RS09975	COG0697	spore germination
L2Z42_RS09985	COG2814	Major facilitator Superfamily
L2Z42_RS09990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z42_RS10000	COG0583	DNA-binding transcription factor activity
L2Z42_RS10010	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Z42_RS10020	COG0084	hydrolase, TatD family'
L2Z42_RS10035	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Z42_RS10085	COG0440	acetolactate synthase activity
L2Z42_RS10090	COG0028	Belongs to the TPP enzyme family
L2Z42_RS10115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z42_RS10120	COG0577	efflux transmembrane transporter activity
L2Z42_RS10120	COG1136	(ABC) transporter
L2Z42_RS10125	COG1538	Outer membrane efflux protein
L2Z42_RS10140	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Z42_RS10145	COG1162	GTPase activity
L2Z42_RS10155	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2Z42_RS10175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L2Z42_RS10180	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z42_RS10220	COG2986	histidine ammonia-lyase
L2Z42_RS10230	COG1216	Glycosyl transferase, family 2
L2Z42_RS10235	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z42_RS10245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z42_RS10290	COG1426	Protein conserved in bacteria
L2Z42_RS10325	COG0793	Belongs to the peptidase S41A family
L2Z42_RS10340	COG2267	carboxylic ester hydrolase activity
L2Z42_RS10350	COG1012	belongs to the aldehyde dehydrogenase family
L2Z42_RS10355	COG3265	gluconokinase activity
L2Z42_RS10365	COG0800	Aldolase
L2Z42_RS10375	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Z42_RS10380	COG0857	belongs to the CobB CobQ family
L2Z42_RS10380	COG0280	phosphate acetyltransferase
L2Z42_RS10385	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z42_RS10385	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z42_RS10405	COG0740	serine-type endopeptidase activity
L2Z42_RS10415	COG4774	siderophore transport
L2Z42_RS10425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z42_RS10435	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z42_RS10435	COG2813	Specifically methylates the guanine in position
L2Z42_RS10535	COG0788	formyltetrahydrofolate deformylase activity
L2Z42_RS10560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z42_RS10560	COG4651	solute:proton antiporter activity
L2Z42_RS10580	COG0724	RNA recognition motif
L2Z42_RS10585	COG0210	DNA helicase
L2Z42_RS10610	COG1733	regulation of RNA biosynthetic process
L2Z42_RS10620	COG2900	Belongs to the SlyX family
L2Z42_RS10625	COG0488	(ABC) transporter
L2Z42_RS10630	COG1280	lysine exporter protein (LysE YggA)
L2Z42_RS10635	COG1560	Kdo2-lipid A biosynthetic process
L2Z42_RS10645	COG1301	dicarboxylic acid transport
L2Z42_RS10700	COG0473	3-isopropylmalate dehydrogenase activity
L2Z42_RS10755	COG0583	DNA-binding transcription factor activity
L2Z42_RS10765	COG0625	glutathione transferase activity
L2Z42_RS10770	COG2378	regulation of single-species biofilm formation
L2Z42_RS10775	COG0546	phosphoglycolate phosphatase activity
L2Z42_RS10785	COG1530	ribonuclease E activity
L2Z42_RS10790	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z42_RS10805	COG0583	DNA-binding transcription factor activity
L2Z42_RS10810	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z42_RS10815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z42_RS10825	COG0534	Mate efflux family protein
L2Z42_RS10840	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Z42_RS10865	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z42_RS10865	COG0493	'glutamate synthase
L2Z42_RS10875	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2Z42_RS10880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z42_RS10895	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z42_RS10905	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2Z42_RS10905	COG0644	oxidoreductase
L2Z42_RS10915	COG0425	Belongs to the sulfur carrier protein TusA family
L2Z42_RS10920	COG4535	Mg2 and Co2 transporter CorC
L2Z42_RS10930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z42_RS10950	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Z42_RS10955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z42_RS10955	COG0475	glutathione-regulated potassium exporter activity
L2Z42_RS10970	COG0484	heat shock protein binding
L2Z42_RS10975	COG0789	Transcriptional regulator
L2Z42_RS10980	COG0598	Magnesium transport protein CorA
L2Z42_RS10995	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z42_RS11000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z42_RS11005	COG1074	ATP-dependent DNA helicase activity
L2Z42_RS11010	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Z42_RS11030	COG2226	methyltransferase
L2Z42_RS11050	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Z42_RS11065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z42_RS11065	COG2111	Na H antiporter
L2Z42_RS11070	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Z42_RS11075	COG0651	ATP synthesis coupled electron transport
L2Z42_RS11080	COG1863	multisubunit Na H antiporter MnhE subunit
L2Z42_RS11085	COG2212	antiporter activity
L2Z42_RS11090	COG1320	monovalent cation:proton antiporter activity
L2Z42_RS11105	COG0195	Participates in both transcription termination and antitermination
L2Z42_RS11155	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L2Z42_RS11160	COG0237	dephospho-CoA kinase activity
L2Z42_RS11170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z42_RS11185	COG0497	DNA recombination
L2Z42_RS11195	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Z42_RS11225	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z42_RS11225	COG2169	Transcriptional regulator
L2Z42_RS11230	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2Z42_RS11300	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2Z42_RS11315	COG0326	Molecular chaperone. Has ATPase activity
L2Z42_RS11330	COG2056	Na+-H+ antiporter family
L2Z42_RS11335	COG0596	Alpha beta hydrolase
L2Z42_RS11430	COG0546	phosphoglycolate phosphatase activity
L2Z42_RS11435	COG1716	ATPase activity
L2Z42_RS11480	COG0181	hydroxymethylbilane synthase activity
L2Z42_RS11490	COG3275	phosphorelay sensor kinase activity
L2Z42_RS11510	COG1538	Outer membrane efflux protein
L2Z42_RS11515	COG0697	spore germination
L2Z42_RS11540	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z42_RS11545	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Z42_RS11550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z42_RS11555	COG0772	Belongs to the SEDS family
L2Z42_RS11580	COG4974	Belongs to the 'phage' integrase family
L2Z42_RS11585	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z42_RS11595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2Z42_RS11605	COG2197	response regulator
L2Z42_RS11620	COG0793	Belongs to the peptidase S41A family
L2Z42_RS11625	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Z42_RS11630	COG0795	lipopolysaccharide-transporting ATPase activity
L2Z42_RS11670	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z42_RS11670	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z42_RS11680	COG0004	ammonium transporteR
L2Z42_RS11685	COG0347	Belongs to the P(II) protein family
L2Z42_RS11705	COG0659	secondary active sulfate transmembrane transporter activity
L2Z42_RS11710	COG0589	response to stress
L2Z42_RS11775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z42_RS11795	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Z42_RS11810	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z42_RS11820	COG0477	Major facilitator Superfamily
L2Z42_RS11825	COG2860	membrane
L2Z42_RS11830	COG3012	SEC-C Motif Domain Protein
L2Z42_RS11835	COG1253	flavin adenine dinucleotide binding
L2Z42_RS11845	COG0477	Major facilitator Superfamily
L2Z42_RS11855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z42_RS11895	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2Z42_RS11905	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2Z42_RS11975	COG0758	DNA mediated transformation
L2Z42_RS11985	COG0697	spore germination
L2Z42_RS11990	COG1309	transcriptional regulator
L2Z42_RS12005	COG0386	Belongs to the glutathione peroxidase family
L2Z42_RS12075	COG1121	(ABC) transporter
L2Z42_RS12080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Z42_RS12085	COG1280	lysine exporter protein (LysE YggA)
L2Z42_RS12090	COG2837	iron assimilation
L2Z42_RS12095	COG0281	malic enzyme
L2Z42_RS12140	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z42_RS12140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z42_RS12145	COG4399	Belongs to the UPF0754 family
L2Z42_RS12150	COG2259	Doxx family
L2Z42_RS12155	COG0586	Pfam SNARE associated Golgi protein
L2Z42_RS12170	COG1192	Involved in chromosome partitioning
L2Z42_RS12180	COG0271	Belongs to the BolA IbaG family
L2Z42_RS12220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z42_RS12220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Z42_RS12220	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
L2Z42_RS12220	COG3321	synthase
L2Z42_RS12225	COG1960	acyl-CoA dehydrogenase activity
L2Z42_RS12230	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z42_RS12235	COG2197	response regulator
L2Z42_RS12245	COG3916	Acyl-homoserine-lactone synthase
L2Z42_RS12250	COG0477	Major facilitator Superfamily
L2Z42_RS12255	COG1024	Enoyl-CoA hydratase
L2Z42_RS12260	COG1024	Enoyl-CoA hydratase
L2Z42_RS12265	COG1960	acyl-CoA dehydrogenase activity
L2Z42_RS12270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z42_RS12290	COG1113	amino acid transport
L2Z42_RS12295	COG1113	amino acid transport
L2Z42_RS12300	COG0251	oxidation-reduction process
L2Z42_RS12340	COG0564	pseudouridine synthase activity
L2Z42_RS12425	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2Z42_RS12440	COG1802	Transcriptional regulator
L2Z42_RS12450	COG1448	Aminotransferase
L2Z42_RS12455	COG0277	FAD linked oxidase domain protein
L2Z42_RS12465	COG2186	Transcriptional regulator
L2Z42_RS12475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z42_RS12480	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z42_RS12495	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Z42_RS12500	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L2Z42_RS12525	COG0438	transferase activity, transferring glycosyl groups
L2Z42_RS12555	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z42_RS12585	COG0728	peptidoglycan biosynthetic process
L2Z42_RS12590	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2Z42_RS12650	COG0546	phosphoglycolate phosphatase activity
L2Z42_RS12655	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z42_RS12675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z42_RS12680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z42_RS12685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z42_RS12690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z42_RS12695	COG1116	anion transmembrane transporter activity
L2Z42_RS12700	COG1309	transcriptional regulator
L2Z42_RS12705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2Z42_RS12715	COG0196	riboflavin kinase activity
L2Z42_RS12720	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Z42_RS12730	COG1047	Peptidyl-prolyl cis-trans
L2Z42_RS12770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2Z42_RS12775	COG0657	acetylesterase activity
L2Z42_RS12795	COG0583	DNA-binding transcription factor activity
L2Z42_RS12825	COG2951	lytic endotransglycosylase activity
L2Z42_RS12830	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Z42_RS12845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Z42_RS12855	COG0671	phosphoesterase, PA-phosphatase related
L2Z42_RS12860	COG0861	Integral membrane protein TerC family
L2Z42_RS12870	COG0754	glutathionylspermidine amidase activity
L2Z42_RS12880	COG0402	S-adenosylhomocysteine deaminase activity
L2Z42_RS12895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z42_RS12900	COG1230	cation diffusion facilitator family transporter
L2Z42_RS12915	COG0706	membrane insertase activity
L2Z42_RS12940	COG0592	DNA-directed DNA polymerase activity
L2Z42_RS12950	COG0187	DNA topoisomerase II activity
L2Z42_RS12960	COG0586	Pfam SNARE associated Golgi protein
L2Z42_RS12965	COG0488	(ABC) transporter
L2Z42_RS12995	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2Z42_RS13000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2Z42_RS13040	COG0733	neurotransmitter:sodium symporter activity
L2Z42_RS13080	COG2233	PERMEase
L2Z42_RS13095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z42_RS13130	COG2814	Major facilitator Superfamily
L2Z42_RS13135	COG0656	L-ascorbic acid biosynthetic process
L2Z42_RS13140	COG0583	DNA-binding transcription factor activity
L2Z42_RS13155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z42_RS13160	COG1064	alcohol dehydrogenase
L2Z42_RS13165	COG2818	Glycosylase
L2Z42_RS13180	COG1194	a g-specific adenine glycosylase
L2Z42_RS13200	COG2983	Belongs to the UPF0260 family
L2Z42_RS13205	COG2133	pyrroloquinoline quinone binding
L2Z42_RS13210	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Z42_RS13215	COG2116	formate transmembrane transporter activity
L2Z42_RS13235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z42_RS13240	COG1335	isochorismatase
L2Z42_RS13245	COG0385	Bile acid
L2Z42_RS13250	COG0534	Mate efflux family protein
L2Z42_RS13255	COG1683	Conserved Protein
L2Z42_RS13275	COG0625	glutathione transferase activity
L2Z42_RS13285	COG1113	amino acid transport
L2Z42_RS13295	COG0523	cobalamin synthesis protein
L2Z42_RS13305	COG2188	Transcriptional regulator
L2Z42_RS13335	COG0010	Belongs to the arginase family
L2Z42_RS13355	COG1280	lysine exporter protein (LysE YggA)
L2Z42_RS13370	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2Z42_RS13380	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Z42_RS13385	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2Z42_RS13430	COG0753	catalase activity
L2Z42_RS13480	COG0534	Mate efflux family protein
L2Z42_RS13485	COG0436	Aminotransferase
L2Z42_RS13490	COG2733	membrane
L2Z42_RS13505	COG2918	glutathione biosynthetic process
L2Z42_RS13520	COG1388	LysM domain
L2Z42_RS13520	COG1705	Flagellar rod assembly protein muramidase FlgJ
L2Z42_RS13565	COG3150	esterase
L2Z42_RS13575	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2Z42_RS13585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z42_RS13595	COG2233	PERMEase
L2Z42_RS13600	COG2351	hydroxyisourate hydrolase activity
L2Z42_RS13635	COG3706	GGDEF domain
L2Z42_RS13650	COG1393	Belongs to the ArsC family
L2Z42_RS13655	COG0708	Exodeoxyribonuclease III
L2Z42_RS13680	COG0189	ligase activity
L2Z42_RS13700	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Z42_RS13710	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Z42_RS13725	COG4942	peptidase
L2Z42_RS13735	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z42_RS13745	COG2119	membrane
L2Z42_RS13750	COG4774	siderophore transport
L2Z42_RS13755	COG0426	domain, Protein
L2Z42_RS13755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z42_RS13780	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2Z42_RS13800	COG1902	pentaerythritol trinitrate reductase activity
L2Z42_RS13805	COG1519	Transferase
L2Z42_RS13815	COG0668	transmembrane transport
L2Z42_RS13825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z42_RS13830	COG1335	isochorismatase
L2Z42_RS13835	COG1522	sequence-specific DNA binding
L2Z42_RS13860	COG0784	Response regulator, receiver
L2Z42_RS13860	COG2205	protein histidine kinase activity
L2Z42_RS13860	COG2198	Histidine kinase
L2Z42_RS13865	COG3162	membrane
L2Z42_RS13870	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z42_RS13880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z42_RS13895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2Z42_RS13900	COG1309	transcriptional regulator
L2Z42_RS13920	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z42_RS13920	COG0351	phosphomethylpyrimidine kinase
L2Z42_RS13920	COG0352	thiamine-phosphate diphosphorylase activity
L2Z42_RS13930	COG2814	Major facilitator Superfamily
L2Z42_RS13955	COG1113	amino acid transport
L2Z42_RS13965	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z42_RS13970	COG1012	belongs to the aldehyde dehydrogenase family
L2Z42_RS13980	COG1335	isochorismatase
L2Z42_RS14020	COG2814	Major facilitator Superfamily
L2Z42_RS14025	COG0583	DNA-binding transcription factor activity
L2Z42_RS14070	COG1733	regulation of RNA biosynthetic process
L2Z42_RS14100	COG1733	regulation of RNA biosynthetic process
L2Z42_RS14105	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z42_RS14125	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
L2Z42_RS14130	COG2207	Transcriptional regulator
L2Z42_RS14185	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Z42_RS14200	COG2329	Antibiotic biosynthesis monooxygenase
L2Z42_RS14230	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Z42_RS14255	COG0427	acetyl-CoA hydrolase
L2Z42_RS14280	COG0659	secondary active sulfate transmembrane transporter activity
L2Z42_RS14285	COG4221	oxidoreductase activity
L2Z42_RS14310	COG0488	(ABC) transporter
L2Z42_RS14375	COG0833	amino acid
L2Z42_RS14420	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Z42_RS14425	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Z42_RS14440	COG2226	methyltransferase
L2Z42_RS14490	COG0067	glutamate synthase
L2Z42_RS14490	COG0069	glutamate synthase activity
L2Z42_RS14490	COG0070	glutamate synthase
L2Z42_RS14495	COG0493	'glutamate synthase
L2Z42_RS14505	COG1704	LemA family
L2Z42_RS14510	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2Z42_RS14520	COG4969	Belongs to the N-Me-Phe pilin family
L2Z42_RS14525	COG3307	-O-antigen
L2Z42_RS14545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z42_RS14560	COG0194	GDP metabolic process
L2Z42_RS14610	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Z42_RS14630	COG5380	lipid catabolic process
L2Z42_RS14635	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Z42_RS14660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Z42_RS14665	COG0277	FAD linked oxidase domain protein
L2Z42_RS14675	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2Z42_RS14680	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z42_RS14695	COG1289	transmembrane transporter activity
L2Z42_RS14705	COG0628	permease
L2Z42_RS14710	COG1192	Involved in chromosome partitioning
L2Z42_RS14740	COG0833	amino acid
L2Z42_RS14745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z42_RS14750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z42_RS14760	COG1012	belongs to the aldehyde dehydrogenase family
L2Z42_RS14800	COG0583	DNA-binding transcription factor activity
L2Z42_RS14850	COG0517	IMP dehydrogenase activity
L2Z42_RS14855	COG1983	PspC domain protein
L2Z42_RS14865	COG1960	acyl-CoA dehydrogenase activity
L2Z42_RS14880	COG0408	coproporphyrinogen oxidase activity
L2Z42_RS14900	COG0513	Belongs to the DEAD box helicase family
L2Z42_RS14910	COG1127	ABC transporter
L2Z42_RS14915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Z42_RS14925	COG2854	intermembrane phospholipid transfer
L2Z42_RS14935	COG0598	Magnesium transport protein CorA
L2Z42_RS14945	COG0494	nUDIX hydrolase
L2Z42_RS14950	COG1040	competence protein
L2Z42_RS14955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2Z42_RS14975	COG1946	Acyl-CoA thioesterase
L2Z42_RS14980	COG1301	dicarboxylic acid transport
L2Z42_RS14995	COG1959	2 iron, 2 sulfur cluster binding
L2Z42_RS15000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z42_RS15000	COG1017	nitric oxide dioxygenase activity
L2Z42_RS15010	COG0433	COG0433 Predicted ATPase
L2Z42_RS15015	COG0626	cystathionine gamma-synthase activity
L2Z42_RS15170	COG1960	acyl-CoA dehydrogenase activity
L2Z42_RS15175	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Z42_RS15205	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2Z42_RS15210	COG0339	signal peptide processing
L2Z42_RS15215	COG0557	exoribonuclease II activity
L2Z42_RS15260	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Z42_RS15265	COG2169	Transcriptional regulator
L2Z42_RS15270	COG0697	spore germination
L2Z42_RS15275	COG1295	ribonuclease BN
L2Z42_RS15310	COG1702	phosphate starvation-inducible protein PhoH
L2Z42_RS15320	COG0741	lytic transglycosylase activity
L2Z42_RS15320	COG1196	nuclear chromosome segregation
L2Z42_RS15320	COG0739	heme binding
L2Z42_RS15350	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Z42_RS15355	COG1183	phosphatidylcholine synthase activity
L2Z42_RS15400	COG1960	acyl-CoA dehydrogenase activity
L2Z42_RS15405	COG1309	transcriptional regulator
L2Z42_RS15420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z42_RS15425	COG1960	acyl-CoA dehydrogenase activity
L2Z42_RS15445	COG2969	positive regulation of protein catabolic process
L2Z42_RS15455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Z42_RS15465	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
L2Z42_RS15470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Z42_RS15475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z42_RS15495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Z42_RS15505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z42_RS15520	COG2199	diguanylate cyclase activity
L2Z42_RS15580	COG1607	acyl-coa hydrolase
L2Z42_RS15610	COG3013	Belongs to the UPF0304 family
L2Z42_RS15690	COG2205	protein histidine kinase activity
L2Z42_RS15705	COG2132	Multicopper oxidase
L2Z42_RS15730	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z42_RS15780	COG0582	viral genome integration into host DNA
L2Z42_RS15805	COG2350	Protein conserved in bacteria
L2Z42_RS15815	COG0613	PHP domain protein
L2Z42_RS15820	COG3781	membrane
L2Z42_RS15830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Z42_RS15835	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2Z42_RS15845	COG1862	Preprotein translocase
L2Z42_RS15875	COG0582	viral genome integration into host DNA
L2Z42_RS15895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z42_RS15915	COG2205	protein histidine kinase activity
L2Z42_RS15920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Z42_RS15940	COG0726	polysaccharide deacetylase
L2Z42_RS15945	COG0463	Glycosyl transferase, family 2
L2Z42_RS15950	COG0438	transferase activity, transferring glycosyl groups
L2Z42_RS15965	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L2Z42_RS16015	COG1960	acyl-CoA dehydrogenase activity
L2Z42_RS16020	COG1960	acyl-CoA dehydrogenase activity
L2Z42_RS16030	COG2205	protein histidine kinase activity
L2Z42_RS16035	COG0745	RESPONSE REGULATOR receiver
L2Z42_RS16040	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Z42_RS16060	COG2096	Adenosyltransferase
L2Z42_RS16065	COG4206	TonB-dependent receptor
L2Z42_RS16110	COG0285	dihydrofolate synthase activity
L2Z42_RS16130	COG0450	alkyl hydroperoxide reductase
L2Z42_RS16145	COG0477	Major facilitator Superfamily
L2Z42_RS16150	COG1272	protein, Hemolysin III
L2Z42_RS16160	COG2153	protein acetylation
L2Z42_RS16180	COG0183	Belongs to the thiolase family
L2Z42_RS16185	COG2207	Transcriptional regulator
L2Z42_RS16205	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z42_RS16225	COG0183	Belongs to the thiolase family
L2Z42_RS16245	COG1690	Belongs to the RtcB family
L2Z42_RS16250	COG0833	amino acid
L2Z42_RS16260	COG2233	PERMEase
L2Z42_RS16265	COG1217	gtp-binding protein TYPA
L2Z42_RS16290	COG2094	Belongs to the DNA glycosylase MPG family
L2Z42_RS16295	COG4772	TonB-dependent receptor
L2Z42_RS16300	COG1902	pentaerythritol trinitrate reductase activity
L2Z42_RS16315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z42_RS16320	COG0354	folic acid binding
L2Z42_RS16330	COG3189	MarR family transcriptional regulator
L2Z42_RS16335	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Z42_RS16340	COG3422	double-strand break repair
L2Z42_RS16380	COG0840	transmembrane signaling receptor activity
L2Z42_RS16400	COG5510	response to toxic substance
L2Z42_RS16410	COG2832	Protein of unknown function (DUF454)
L2Z42_RS16415	COG1376	ErfK ybiS ycfS ynhG family protein
L2Z42_RS16455	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Z42_RS16465	COG1289	transmembrane transporter activity
L2Z42_RS16470	COG2814	Major facilitator Superfamily
L2Z42_RS16490	COG1115	amino acid carrier protein
L2Z42_RS16495	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z42_RS16500	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z42_RS16505	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2Z42_RS16510	COG3590	peptidase
L2Z42_RS16535	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z42_RS16545	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z42_RS16550	COG1077	Cell shape determining protein MreB Mrl
L2Z42_RS16555	COG1792	Involved in formation and maintenance of cell shape
L2Z42_RS16560	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2Z42_RS16565	COG0424	maF-like protein
L2Z42_RS16570	COG1530	ribonuclease E activity
L2Z42_RS16580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z42_RS16590	COG0560	Phosphoserine phosphatase
L2Z42_RS16600	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z42_RS16625	COG2207	Transcriptional regulator
L2Z42_RS16645	COG1113	amino acid transport
L2Z42_RS16650	COG2828	Protein conserved in bacteria
L2Z42_RS16655	COG0142	geranyltranstransferase activity
L2Z42_RS16660	COG2315	Protein conserved in bacteria
L2Z42_RS16675	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z42_RS16695	COG2194	sulfuric ester hydrolase activity
L2Z42_RS16700	COG0745	RESPONSE REGULATOR receiver
L2Z42_RS16705	COG0642	Histidine kinase
L2Z42_RS16715	COG0004	ammonium transporteR
L2Z42_RS16720	COG0583	DNA-binding transcription factor activity
L2Z42_RS16740	COG0525	valine-tRNA ligase activity
L2Z42_RS16750	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z42_RS16760	COG0393	Putative heavy-metal-binding
L2Z42_RS16765	COG0393	Putative heavy-metal-binding
L2Z42_RS16770	COG1538	Outer membrane efflux protein
L2Z42_RS16780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z42_RS16785	COG0671	phosphoesterase, PA-phosphatase related
L2Z42_RS16815	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Z42_RS16830	COG1648	precorrin-2 dehydrogenase activity
L2Z42_RS16830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Z42_RS16835	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Z42_RS16840	COG1733	regulation of RNA biosynthetic process
L2Z42_RS16850	COG0531	amino acid
L2Z42_RS16865	COG0321	lipoyl(octanoyl) transferase activity
L2Z42_RS16870	COG2921	Belongs to the UPF0250 family
L2Z42_RS16910	COG2009	succinate dehydrogenase
L2Z42_RS16915	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Z42_RS16920	COG1053	succinate dehydrogenase
L2Z42_RS16925	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Z42_RS16950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z42_RS16970	COG2354	Protein conserved in bacteria
L2Z42_RS16975	COG2321	neutral zinc metallopeptidase
L2Z42_RS16995	COG2843	Capsule synthesis protein
L2Z42_RS17010	COG0589	response to stress
L2Z42_RS17020	COG0251	oxidation-reduction process
L2Z42_RS17040	COG0505	Belongs to the CarA family
L2Z42_RS17065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z42_RS17070	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Z42_RS17120	COG0477	Major facilitator Superfamily
L2Z42_RS17125	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2Z42_RS17140	COG1597	lipid kinase activity
L2Z42_RS17145	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z42_RS17165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z42_RS17170	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z42_RS17190	COG0741	lytic transglycosylase activity
L2Z42_RS17210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z42_RS17225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z42_RS17235	COG3811	Belongs to the UPF0386 family
L2Z42_RS17295	COG0778	Nitroreductase
L2Z42_RS17310	COG1929	Belongs to the glycerate kinase type-1 family
L2Z42_RS17315	COG0243	molybdopterin cofactor binding
L2Z42_RS17320	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2Z42_RS17325	COG3339	Conserved Protein
L2Z42_RS17335	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Z42_RS17350	COG1113	amino acid transport
L2Z42_RS17360	COG0019	diaminopimelate decarboxylase activity
L2Z42_RS17370	COG1280	lysine exporter protein (LysE YggA)
L2Z42_RS17375	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z42_RS17405	COG0463	Glycosyl transferase, family 2
L2Z42_RS17425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z42_RS17460	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Z42_RS17465	COG1136	(ABC) transporter
L2Z42_RS17470	COG2333	competence protein COMEC
L2Z42_RS17470	COG0658	competence protein
L2Z42_RS17480	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Z42_RS17480	COG0616	signal peptide processing
L2Z42_RS17485	COG0596	Alpha beta hydrolase
L2Z42_RS17490	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Z42_RS17500	COG0628	permease
L2Z42_RS17535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z42_RS17555	COG0823	Involved in the tonB-independent uptake of proteins
L2Z42_RS17575	COG0824	Thioesterase
L2Z42_RS17580	COG1473	amidohydrolase
L2Z42_RS17600	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2Z42_RS17600	COG0047	phosphoribosylformylglycinamidine synthase activity
L2Z42_RS17625	COG1169	isochorismate synthase
L2Z42_RS17635	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z42_RS17640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z42_RS17655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z42_RS17660	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z42_RS17665	COG3486	L-lysine 6-monooxygenase (NADPH) activity
L2Z42_RS17670	COG0019	diaminopimelate decarboxylase activity
L2Z42_RS17690	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z42_RS17695	COG4774	siderophore transport
L2Z42_RS17710	COG0534	Mate efflux family protein
L2Z42_RS17720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z42_RS17790	COG1024	Enoyl-CoA hydratase
L2Z42_RS17795	COG1056	cytidyltransferase-related domain
L2Z42_RS17795	COG1051	belongs to the nudix hydrolase family
L2Z42_RS17805	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Z42_RS17820	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2Z42_RS17835	COG4625	pathogenesis
L2Z42_RS17840	COG0583	DNA-binding transcription factor activity
L2Z42_RS17845	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2Z42_RS17850	COG4208	sulfate ABC transporter
L2Z42_RS17855	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2Z42_RS17865	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2Z42_RS17870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2Z42_RS17875	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Z42_RS17895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z42_RS17905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L2Z42_RS17915	COG0681	Belongs to the peptidase S26 family
L2Z42_RS17930	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Z42_RS17940	COG1381	Involved in DNA repair and RecF pathway recombination
L2Z42_RS17945	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Z42_RS17955	COG4221	oxidoreductase activity
L2Z42_RS17985	COG0443	Heat shock 70 kDa protein
L2Z42_RS17995	COG0436	Aminotransferase
L2Z42_RS18015	COG0556	nucleotide-excision repair
L2Z42_RS18070	COG2070	2-Nitropropane dioxygenase
L2Z42_RS18100	COG1215	transferase activity, transferring glycosyl groups
L2Z42_RS18115	COG0415	Belongs to the DNA photolyase family
L2Z42_RS18125	COG1252	NADH dehydrogenase
L2Z42_RS18130	COG1686	Belongs to the peptidase S11 family
L2Z42_RS18145	COG1187	pseudouridine synthase activity
L2Z42_RS18170	COG0477	Major facilitator Superfamily
L2Z42_RS18175	COG0583	DNA-binding transcription factor activity
L2Z42_RS18180	COG1823	symporter activity
L2Z42_RS18190	COG0612	Peptidase, M16
L2Z42_RS18215	COG0352	thiamine-phosphate diphosphorylase activity
L2Z42_RS18250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z42_RS18260	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z42_RS18275	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z42_RS18280	COG0076	glutamate decarboxylase activity
L2Z42_RS18290	COG1522	sequence-specific DNA binding
L2Z42_RS18295	COG3961	Belongs to the TPP enzyme family
L2Z42_RS18300	COG1113	amino acid transport
L2Z42_RS18305	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Z42_RS18310	COG0573	inorganic phosphate transmembrane transporter activity
L2Z42_RS18320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Z42_RS18325	COG0616	signal peptide processing
L2Z42_RS18360	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Z42_RS18365	COG1686	Belongs to the peptidase S11 family
L2Z42_RS18390	COG0583	DNA-binding transcription factor activity
L2Z42_RS18395	COG1067	ATP-dependent peptidase activity
L2Z42_RS18420	COG4943	cyclic-guanylate-specific phosphodiesterase activity
L2Z42_RS18440	COG1966	Carbon starvation protein
L2Z42_RS18445	COG2879	small protein
L2Z42_RS18500	COG1335	isochorismatase
L2Z42_RS18505	COG0583	DNA-binding transcription factor activity
L2Z42_RS18520	COG0596	Alpha beta hydrolase
L2Z42_RS18530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z42_RS18575	COG1741	Belongs to the pirin family
L2Z42_RS18585	COG2964	Protein conserved in bacteria
L2Z42_RS18600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z42_RS18605	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z42_RS18610	COG4605	iron ion homeostasis
L2Z42_RS18615	COG4604	ABC transporter, ATP-binding protein
L2Z42_RS18620	COG4607	ABC-type enterochelin transport system periplasmic component
L2Z42_RS18625	COG4774	siderophore transport
L2Z42_RS18635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z42_RS18640	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z42_RS18645	COG3433	isochorismatase activity
L2Z42_RS18645	COG1535	isochorismatase
L2Z42_RS18655	COG1132	(ABC) transporter
L2Z42_RS18660	COG1132	(ABC) transporter
L2Z42_RS18665	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z42_RS18690	COG3739	integral membrane protein