locus-tag	class	description
HKO16_RS00010	COG0592	DNA-directed DNA polymerase activity
HKO16_RS00020	COG0187	DNA topoisomerase II activity
HKO16_RS00030	COG0586	Pfam SNARE associated Golgi protein
HKO16_RS00035	COG0488	(ABC) transporter
HKO16_RS00060	COG0596	Alpha beta hydrolase
HKO16_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HKO16_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HKO16_RS00110	COG0733	neurotransmitter:sodium symporter activity
HKO16_RS00150	COG2233	PERMEase
HKO16_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKO16_RS00200	COG2814	Major facilitator Superfamily
HKO16_RS00205	COG0656	L-ascorbic acid biosynthetic process
HKO16_RS00210	COG0583	DNA-binding transcription factor activity
HKO16_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKO16_RS00230	COG1064	alcohol dehydrogenase
HKO16_RS00235	COG2818	Glycosylase
HKO16_RS00250	COG1194	a g-specific adenine glycosylase
HKO16_RS00270	COG2983	Belongs to the UPF0260 family
HKO16_RS00275	COG2133	pyrroloquinoline quinone binding
HKO16_RS00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HKO16_RS00285	COG2116	formate transmembrane transporter activity
HKO16_RS00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKO16_RS00310	COG1335	isochorismatase
HKO16_RS00315	COG0385	Bile acid
HKO16_RS00320	COG0534	Mate efflux family protein
HKO16_RS00325	COG1683	Conserved Protein
HKO16_RS00345	COG0625	glutathione transferase activity
HKO16_RS00355	COG1113	amino acid transport
HKO16_RS00365	COG0523	cobalamin synthesis protein
HKO16_RS00375	COG2188	Transcriptional regulator
HKO16_RS00405	COG0010	Belongs to the arginase family
HKO16_RS00425	COG1280	lysine exporter protein (LysE YggA)
HKO16_RS00440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HKO16_RS00450	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HKO16_RS00455	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HKO16_RS00500	COG0753	catalase activity
HKO16_RS00550	COG0534	Mate efflux family protein
HKO16_RS00555	COG0436	Aminotransferase
HKO16_RS00560	COG2733	membrane
HKO16_RS00575	COG2918	glutathione biosynthetic process
HKO16_RS00610	COG0640	Transcriptional regulator
HKO16_RS00635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HKO16_RS00710	COG1525	nuclease
HKO16_RS00830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HKO16_RS00880	COG1192	Involved in chromosome partitioning
HKO16_RS00895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HKO16_RS00925	COG0739	heme binding
HKO16_RS01095	COG0501	Belongs to the peptidase M48B family
HKO16_RS01155	COG0589	response to stress
HKO16_RS01160	COG0659	secondary active sulfate transmembrane transporter activity
HKO16_RS01170	COG0606	chelatase, subunit chli
HKO16_RS01180	COG0347	Belongs to the P(II) protein family
HKO16_RS01185	COG0004	ammonium transporteR
HKO16_RS01195	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HKO16_RS01195	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HKO16_RS01235	COG0795	lipopolysaccharide-transporting ATPase activity
HKO16_RS01240	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HKO16_RS01245	COG0793	Belongs to the peptidase S41A family
HKO16_RS01260	COG2197	response regulator
HKO16_RS01270	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HKO16_RS01280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HKO16_RS01285	COG4974	Belongs to the 'phage' integrase family
HKO16_RS01310	COG0772	Belongs to the SEDS family
HKO16_RS01315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HKO16_RS01320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HKO16_RS01325	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HKO16_RS01350	COG0697	spore germination
HKO16_RS01355	COG1538	Outer membrane efflux protein
HKO16_RS01375	COG3275	phosphorelay sensor kinase activity
HKO16_RS01385	COG0181	hydroxymethylbilane synthase activity
HKO16_RS01435	COG1716	ATPase activity
HKO16_RS01440	COG0546	phosphoglycolate phosphatase activity
HKO16_RS01535	COG0596	Alpha beta hydrolase
HKO16_RS01540	COG2056	Na+-H+ antiporter family
HKO16_RS01555	COG0326	Molecular chaperone. Has ATPase activity
HKO16_RS01570	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HKO16_RS01635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HKO16_RS01640	COG2169	Transcriptional regulator
HKO16_RS01640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HKO16_RS01670	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HKO16_RS01680	COG0497	DNA recombination
HKO16_RS01695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HKO16_RS01705	COG0237	dephospho-CoA kinase activity
HKO16_RS01750	COG0195	Participates in both transcription termination and antitermination
HKO16_RS01770	COG2212	antiporter activity
HKO16_RS01780	COG0651	ATP synthesis coupled electron transport
HKO16_RS01785	COG1006	Multisubunit Na H antiporter MnhC subunit
HKO16_RS01790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HKO16_RS01790	COG2111	Na H antiporter
HKO16_RS01805	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HKO16_RS01825	COG2226	methyltransferase
HKO16_RS01845	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HKO16_RS01850	COG1074	ATP-dependent DNA helicase activity
HKO16_RS01855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HKO16_RS01875	COG0598	Magnesium transport protein CorA
HKO16_RS01880	COG0789	Transcriptional regulator
HKO16_RS01885	COG0484	heat shock protein binding
HKO16_RS01900	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HKO16_RS01900	COG0475	glutathione-regulated potassium exporter activity
HKO16_RS01905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HKO16_RS01925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKO16_RS01935	COG4535	Mg2 and Co2 transporter CorC
HKO16_RS01940	COG0425	Belongs to the sulfur carrier protein TusA family
HKO16_RS01950	COG0644	oxidoreductase
HKO16_RS01950	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HKO16_RS01960	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HKO16_RS01975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HKO16_RS01980	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HKO16_RS02015	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HKO16_RS02030	COG0534	Mate efflux family protein
HKO16_RS02040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HKO16_RS02045	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_RS02050	COG0583	DNA-binding transcription factor activity
HKO16_RS02065	COG0318	PFAM AMP-dependent synthetase and ligase
HKO16_RS02070	COG1530	ribonuclease E activity
HKO16_RS02080	COG0546	phosphoglycolate phosphatase activity
HKO16_RS02085	COG2378	regulation of single-species biofilm formation
HKO16_RS02090	COG0625	glutathione transferase activity
HKO16_RS02100	COG0583	DNA-binding transcription factor activity
HKO16_RS02155	COG0473	3-isopropylmalate dehydrogenase activity
HKO16_RS02210	COG1301	dicarboxylic acid transport
HKO16_RS02220	COG1560	Kdo2-lipid A biosynthetic process
HKO16_RS02225	COG1280	lysine exporter protein (LysE YggA)
HKO16_RS02235	COG2900	Belongs to the SlyX family
HKO16_RS02245	COG1733	regulation of RNA biosynthetic process
HKO16_RS02270	COG0210	DNA helicase
HKO16_RS02275	COG0724	RNA recognition motif
HKO16_RS02295	COG4651	solute:proton antiporter activity
HKO16_RS02295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HKO16_RS02320	COG0788	formyltetrahydrofolate deformylase activity
HKO16_RS02420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HKO16_RS02420	COG2813	Specifically methylates the guanine in position
HKO16_RS02440	COG4774	siderophore transport
HKO16_RS02450	COG0740	serine-type endopeptidase activity
HKO16_RS02470	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HKO16_RS02470	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HKO16_RS02475	COG0857	belongs to the CobB CobQ family
HKO16_RS02475	COG0280	phosphate acetyltransferase
HKO16_RS02480	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HKO16_RS02490	COG0800	Aldolase
HKO16_RS02500	COG3265	gluconokinase activity
HKO16_RS02505	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_RS02515	COG2267	carboxylic ester hydrolase activity
HKO16_RS02530	COG0793	Belongs to the peptidase S41A family
HKO16_RS02565	COG1426	Protein conserved in bacteria
HKO16_RS02610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKO16_RS02620	COG0318	PFAM AMP-dependent synthetase and ligase
HKO16_RS02625	COG1216	Glycosyl transferase, family 2
HKO16_RS02635	COG2986	histidine ammonia-lyase
HKO16_RS02675	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_RS02680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKO16_RS02700	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HKO16_RS02710	COG1162	GTPase activity
HKO16_RS02715	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HKO16_RS02730	COG1538	Outer membrane efflux protein
HKO16_RS02735	COG1136	(ABC) transporter
HKO16_RS02735	COG0577	efflux transmembrane transporter activity
HKO16_RS02740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKO16_RS02765	COG0028	Belongs to the TPP enzyme family
HKO16_RS02770	COG0440	acetolactate synthase activity
HKO16_RS02800	COG3501	Rhs element vgr protein
HKO16_RS02820	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HKO16_RS02835	COG0084	hydrolase, TatD family'
HKO16_RS02845	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HKO16_RS02855	COG0583	DNA-binding transcription factor activity
HKO16_RS02865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HKO16_RS02870	COG2814	Major facilitator Superfamily
HKO16_RS02880	COG0697	spore germination
HKO16_RS02910	COG3622	Belongs to the hyi family
HKO16_RS02915	COG2084	Dehydrogenase
HKO16_RS02920	COG1024	Enoyl-CoA hydratase
HKO16_RS02925	COG0784	Response regulator, receiver
HKO16_RS02925	COG2205	protein histidine kinase activity
HKO16_RS02925	COG5002	protein histidine kinase activity
HKO16_RS02945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HKO16_RS02955	COG3956	TIGRFAM MazG family protein
HKO16_RS02960	COG1555	photosystem II stabilization
HKO16_RS02965	COG0617	tRNA 3'-terminal CCA addition
HKO16_RS02970	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HKO16_RS02990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKO16_RS02995	COG3028	Belongs to the UPF0307 family
HKO16_RS03000	COG0318	PFAM AMP-dependent synthetase and ligase
HKO16_RS03015	COG0625	glutathione transferase activity
HKO16_RS03020	COG1238	metal cluster binding
HKO16_RS03060	COG0072	phenylalanine-tRNA ligase activity
HKO16_RS03090	COG0248	Ppx GppA phosphatase
HKO16_RS03100	COG0037	tRNA processing
HKO16_RS03140	COG1764	response to oxidative stress
HKO16_RS03145	COG1846	Transcriptional regulator
HKO16_RS03155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKO16_RS03215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HKO16_RS03220	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HKO16_RS03225	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HKO16_RS03235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HKO16_RS03285	COG1214	PFAM Peptidase M22, glycoprotease
HKO16_RS03310	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HKO16_RS03315	COG0561	phosphatase activity
HKO16_RS03325	COG2132	Multicopper oxidase
HKO16_RS03345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HKO16_RS03350	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HKO16_RS03355	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HKO16_RS03385	COG1063	alcohol dehydrogenase
HKO16_RS03390	COG0583	DNA-binding transcription factor activity
HKO16_RS03395	COG1960	acyl-CoA dehydrogenase activity
HKO16_RS03400	COG2814	Major facilitator Superfamily
HKO16_RS03405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HKO16_RS03415	COG1053	succinate dehydrogenase
HKO16_RS03420	COG0583	DNA-binding transcription factor activity
HKO16_RS03435	COG0583	DNA-binding transcription factor activity
HKO16_RS03445	COG1473	amidohydrolase
HKO16_RS03465	COG0583	DNA-binding transcription factor activity
HKO16_RS03480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HKO16_RS03525	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKO16_RS03540	COG0745	RESPONSE REGULATOR receiver
HKO16_RS03545	COG2205	protein histidine kinase activity
HKO16_RS03580	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HKO16_RS03610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HKO16_RS03615	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKO16_RS03640	COG0583	DNA-binding transcription factor activity
HKO16_RS03660	COG0668	transmembrane transport
HKO16_RS03670	COG2081	HI0933 family
HKO16_RS03675	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HKO16_RS03705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKO16_RS03705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKO16_RS03715	COG0489	protein tyrosine kinase activity
HKO16_RS03765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HKO16_RS03775	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HKO16_RS03790	COG0730	response to heat
HKO16_RS03800	COG1196	nuclear chromosome segregation
HKO16_RS03820	COG2223	nitrite transmembrane transporter activity
HKO16_RS03825	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HKO16_RS03830	COG1877	trehalose-phosphatase activity
HKO16_RS03835	COG2226	methyltransferase
HKO16_RS03835	COG0596	Alpha beta hydrolase
HKO16_RS03835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HKO16_RS03850	COG4106	trans-aconitate 2-methyltransferase activity
HKO16_RS03865	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HKO16_RS03870	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HKO16_RS03875	COG0009	L-threonylcarbamoyladenylate synthase
HKO16_RS03880	COG3101	peptidyl-lysine hydroxylation
HKO16_RS03885	COG1399	metal-binding, possibly nucleic acid-binding protein
HKO16_RS03910	COG1652	LysM domain
HKO16_RS03915	COG0351	phosphomethylpyrimidine kinase
HKO16_RS03915	COG0352	thiamine-phosphate diphosphorylase activity
HKO16_RS03915	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HKO16_RS03925	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HKO16_RS03955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HKO16_RS03985	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HKO16_RS04000	COG0358	DNA primase activity
HKO16_RS04010	COG0564	pseudouridine synthase activity
HKO16_RS04035	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HKO16_RS04055	COG0583	DNA-binding transcription factor activity
HKO16_RS04060	COG0473	3-isopropylmalate dehydrogenase activity
HKO16_RS04080	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_RS04100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKO16_RS04100	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HKO16_RS04160	COG0456	acetyltransferase
HKO16_RS04170	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HKO16_RS04175	COG0492	ferredoxin-NADP+ reductase activity
HKO16_RS04180	COG1674	ftsk spoiiie
HKO16_RS04180	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HKO16_RS04185	COG1280	lysine exporter protein (LysE YggA)
HKO16_RS04200	COG2894	cell division
HKO16_RS04215	COG0204	Acyl-transferase
HKO16_RS04220	COG2885	chlorophyll binding
HKO16_RS04225	COG0210	DNA helicase
HKO16_RS04235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKO16_RS04250	COG0121	glutamine amidotransferase
HKO16_RS04270	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HKO16_RS04275	COG0735	belongs to the Fur family
HKO16_RS04300	COG0420	3'-5' exonuclease activity
HKO16_RS04320	COG1090	epimerase
HKO16_RS04335	COG2050	protein possibly involved in aromatic compounds catabolism
HKO16_RS04345	COG2814	Major facilitator Superfamily
HKO16_RS04350	COG0405	Gamma-glutamyltransferase
HKO16_RS04390	COG0477	Major facilitator Superfamily
HKO16_RS04395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKO16_RS04420	COG0531	amino acid
HKO16_RS04425	COG2040	homocysteine
HKO16_RS04450	COG1309	transcriptional regulator
HKO16_RS04455	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HKO16_RS04460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HKO16_RS04470	COG1607	acyl-coa hydrolase
HKO16_RS04480	COG0523	cobalamin synthesis protein
HKO16_RS04490	COG4681	YaeQ
HKO16_RS04500	COG0726	polysaccharide deacetylase
HKO16_RS04500	COG1649	PFAM Uncharacterised BCR, COG1649
HKO16_RS04505	COG1215	transferase activity, transferring glycosyl groups
HKO16_RS04515	COG1024	Enoyl-CoA hydratase
HKO16_RS04530	COG1414	Transcriptional regulator
HKO16_RS04550	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_RS04560	COG0446	pyridine nucleotide-disulphide oxidoreductase
HKO16_RS04565	COG2271	Major facilitator Superfamily
HKO16_RS04575	COG2267	carboxylic ester hydrolase activity
HKO16_RS04580	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_RS04595	COG0028	Belongs to the TPP enzyme family
HKO16_RS04605	COG0477	Major facilitator Superfamily
HKO16_RS04610	COG0242	peptide deformylase activity
HKO16_RS04615	COG2066	Belongs to the glutaminase family
HKO16_RS04620	COG2207	Transcriptional regulator
HKO16_RS04625	COG2223	nitrite transmembrane transporter activity
HKO16_RS04645	COG0583	DNA-binding transcription factor activity
HKO16_RS04650	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_RS04655	COG2271	Major facilitator Superfamily
HKO16_RS04660	COG3959	Transketolase, thiamine diphosphate binding domain
HKO16_RS04665	COG3958	Transketolase
HKO16_RS04675	COG0306	phosphate transporter
HKO16_RS04695	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HKO16_RS04740	COG4181	ATPase activity
HKO16_RS04745	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HKO16_RS04775	COG0583	DNA-binding transcription factor activity
HKO16_RS04785	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKO16_RS04790	COG1773	rubredoxin
HKO16_RS04840	COG2851	Citrate transporter
HKO16_RS04845	COG1253	flavin adenine dinucleotide binding
HKO16_RS04890	COG0804	urea catabolic process
HKO16_RS04900	COG0830	nickel cation binding
HKO16_RS04915	COG0742	ribosomal rna small subunit methyltransferase
HKO16_RS04920	COG0768	penicillin binding
HKO16_RS04945	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HKO16_RS04950	COG2878	Part of a membrane complex involved in electron transport
HKO16_RS04955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HKO16_RS04965	COG3384	dioxygenase
HKO16_RS04990	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HKO16_RS05030	COG0006	proline dipeptidase activity
HKO16_RS05035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKO16_RS05040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKO16_RS05060	COG1279	arginine transmembrane transporter activity
HKO16_RS05065	COG0583	DNA-binding transcription factor activity
HKO16_RS05105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HKO16_RS05110	COG1388	LysM domain
HKO16_RS05110	COG0741	lytic transglycosylase activity
HKO16_RS05110	COG1388	LysM domain
HKO16_RS05110	COG0741	lytic transglycosylase activity
HKO16_RS05120	COG4174	ABC transporter (Permease)
HKO16_RS05125	COG4239	(ABC) transporter, permease
HKO16_RS05130	COG4172	Belongs to the ABC transporter superfamily
HKO16_RS05150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HKO16_RS05160	COG4251	negative regulation of phosphorylation
HKO16_RS05160	COG3706	GGDEF domain
HKO16_RS05160	COG2203	Gaf domain
HKO16_RS05160	COG5001	Diguanylate cyclase
HKO16_RS05175	COG1902	pentaerythritol trinitrate reductase activity
HKO16_RS05175	COG0446	pyridine nucleotide-disulphide oxidoreductase
HKO16_RS05210	COG0251	oxidation-reduction process
HKO16_RS05220	COG0583	DNA-binding transcription factor activity
HKO16_RS05265	COG1113	amino acid transport
HKO16_RS05275	COG0531	amino acid
HKO16_RS05295	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_RS05315	COG1113	amino acid transport
HKO16_RS05345	COG0697	spore germination
HKO16_RS05350	COG2721	sulfolactate sulfo-lyase activity
HKO16_RS05355	COG2271	Major facilitator Superfamily
HKO16_RS05360	COG4948	Mandelate Racemase Muconate Lactonizing
HKO16_RS05370	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_RS05375	COG2186	Transcriptional regulator
HKO16_RS05400	COG1960	acyl-CoA dehydrogenase activity
HKO16_RS05410	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_RS05415	COG1024	Enoyl-CoA hydratase
HKO16_RS05420	COG2814	Major facilitator Superfamily
HKO16_RS05435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HKO16_RS05480	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HKO16_RS05485	COG2072	flavoprotein involved in K transport
HKO16_RS05490	COG0300	oxidoreductase activity
HKO16_RS05500	COG1309	transcriptional regulator
HKO16_RS05505	COG1741	Belongs to the pirin family
HKO16_RS05520	COG2072	flavoprotein involved in K transport
HKO16_RS05530	COG2252	PERMEase
HKO16_RS05535	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HKO16_RS05540	COG3038	cytochrome b561
HKO16_RS05550	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HKO16_RS05560	COG0527	aspartate kinase activity
HKO16_RS05610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HKO16_RS05615	COG4197	protein conserved in bacteria, prophage-related
HKO16_RS05695	COG5410	chromosome segregation
HKO16_RS05700	COG3567	Phage-associated protein, HI1409 family
HKO16_RS05720	COG3566	protein conserved in bacteria
HKO16_RS05855	COG0582	viral genome integration into host DNA
HKO16_RS05875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HKO16_RS05890	COG0667	Aldo Keto reductase
HKO16_RS05900	COG1765	OsmC-like protein
HKO16_RS05915	COG0542	response to heat
HKO16_RS05950	COG2885	chlorophyll binding
HKO16_RS05960	COG0625	glutathione transferase activity
HKO16_RS05965	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HKO16_RS05985	COG3634	alkyl hydroperoxide reductase activity
HKO16_RS05995	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HKO16_RS06005	COG0450	alkyl hydroperoxide reductase
HKO16_RS06010	COG1643	Atp-dependent helicase
HKO16_RS06025	COG2814	Major facilitator Superfamily
HKO16_RS06030	COG3135	benzoate transporter
HKO16_RS06035	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_RS06040	COG0633	Ferredoxin
HKO16_RS06040	COG0543	2 iron, 2 sulfur cluster binding
HKO16_RS06045	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HKO16_RS06050	COG4638	Rieske (2fe-2S)
HKO16_RS06055	COG0583	DNA-binding transcription factor activity
HKO16_RS06105	COG1570	exodeoxyribonuclease VII activity
HKO16_RS06135	COG1280	lysine exporter protein (LysE YggA)
HKO16_RS06140	COG1278	Cold shock
HKO16_RS06175	COG2814	Major facilitator Superfamily
HKO16_RS06210	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HKO16_RS06210	COG0517	IMP dehydrogenase activity
HKO16_RS06215	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HKO16_RS06225	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HKO16_RS06230	COG1137	ATPase activity
HKO16_RS06235	COG1538	Outer membrane efflux protein
HKO16_RS06265	COG4122	O-methyltransferase activity
HKO16_RS06275	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HKO16_RS06290	COG1522	sequence-specific DNA binding
HKO16_RS06305	COG1560	Kdo2-lipid A biosynthetic process
HKO16_RS06310	COG0598	Magnesium transport protein CorA
HKO16_RS06325	COG2814	Major facilitator Superfamily
HKO16_RS06345	COG1250	3-hydroxyacyl-CoA dehydrogenase
HKO16_RS06380	COG0583	DNA-binding transcription factor activity
HKO16_RS06385	COG1914	H( )-stimulated, divalent metal cation uptake system
HKO16_RS06405	COG4770	biotin carboxylase activity
HKO16_RS06410	COG0038	chloride channel
HKO16_RS06420	COG1309	transcriptional regulator
HKO16_RS06430	COG1063	alcohol dehydrogenase
HKO16_RS06445	COG0439	Biotin carboxylase
HKO16_RS06450	COG2249	NAD(P)H dehydrogenase (quinone) activity
HKO16_RS06455	COG1733	regulation of RNA biosynthetic process
HKO16_RS06470	COG0864	Transcriptional regulator
HKO16_RS06480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKO16_RS06485	COG1116	anion transmembrane transporter activity
HKO16_RS06510	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HKO16_RS06615	COG0590	tRNA wobble adenosine to inosine editing
HKO16_RS06620	COG2807	transmembrane transport
HKO16_RS06635	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HKO16_RS06645	COG0789	Transcriptional regulator
HKO16_RS06655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKO16_RS06675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKO16_RS06700	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_RS06705	COG0531	amino acid
HKO16_RS06710	COG1760	l-serine dehydratase
HKO16_RS06715	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_RS06715	COG2030	dehydratase
HKO16_RS06720	COG3396	Phenylacetate-CoA oxygenase
HKO16_RS06725	COG3460	Phenylacetate-CoA oxygenase
HKO16_RS06730	COG3396	Phenylacetate-CoA oxygenase
HKO16_RS06735	COG2151	metal-sulfur cluster biosynthetic enzyme
HKO16_RS06740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HKO16_RS06745	COG1024	Enoyl-CoA hydratase
HKO16_RS06750	COG1024	Enoyl-CoA hydratase
HKO16_RS06755	COG1250	3-hydroxyacyl-CoA dehydrogenase
HKO16_RS06760	COG0183	Belongs to the thiolase family
HKO16_RS06765	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HKO16_RS06770	COG3327	negative regulation of DNA-templated transcription, initiation
HKO16_RS06780	COG2050	protein possibly involved in aromatic compounds catabolism
HKO16_RS06810	COG0753	catalase activity
HKO16_RS06815	COG3038	cytochrome b561
HKO16_RS06820	COG0583	DNA-binding transcription factor activity
HKO16_RS06830	COG1414	Transcriptional regulator
HKO16_RS06835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKO16_RS06850	COG1840	ABC-type Fe3 transport system, periplasmic component
HKO16_RS06855	COG3842	ATPase activity
HKO16_RS06870	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HKO16_RS06875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HKO16_RS06895	COG0583	DNA-binding transcription factor activity
HKO16_RS06905	COG4770	biotin carboxylase activity
HKO16_RS06910	COG1024	Enoyl-CoA hydratase
HKO16_RS06915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HKO16_RS06920	COG1960	acyl-CoA dehydrogenase activity
HKO16_RS06925	COG1309	transcriptional regulator
HKO16_RS06930	COG0318	PFAM AMP-dependent synthetase and ligase
HKO16_RS06950	COG0583	DNA-binding transcription factor activity
HKO16_RS07000	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_RS07040	COG2205	protein histidine kinase activity
HKO16_RS07040	COG0784	Response regulator, receiver
HKO16_RS07060	COG0765	amino acid transport
HKO16_RS07065	COG0765	amino acid transport
HKO16_RS07075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKO16_RS07080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKO16_RS07105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HKO16_RS07110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HKO16_RS07115	COG1045	serine acetyltransferase
HKO16_RS07130	COG0583	DNA-binding transcription factor activity
HKO16_RS07135	COG0625	glutathione transferase activity
HKO16_RS07140	COG0625	glutathione transferase activity
HKO16_RS07145	COG0583	DNA-binding transcription factor activity
HKO16_RS07155	COG1346	cytolysis
HKO16_RS07160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKO16_RS07175	COG2814	Major facilitator Superfamily
HKO16_RS07185	COG0583	DNA-binding transcription factor activity
HKO16_RS07195	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HKO16_RS07200	COG3052	prosthetic group binding
HKO16_RS07220	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HKO16_RS07240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKO16_RS07250	COG1294	oxidase, subunit
HKO16_RS07255	COG1271	oxidase subunit
HKO16_RS07275	COG0477	Major facilitator Superfamily
HKO16_RS07285	COG4521	taurine ABC transporter
HKO16_RS07290	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HKO16_RS07295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKO16_RS07300	COG2175	clavaminate synthase activity
HKO16_RS07310	COG1953	Uracil, thiamine, allantoin
HKO16_RS07320	COG0583	DNA-binding transcription factor activity
HKO16_RS07330	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HKO16_RS07345	COG0640	Transcriptional regulator
HKO16_RS07350	COG0798	PFAM Bile acid sodium symporter
HKO16_RS07355	COG0583	DNA-binding transcription factor activity
HKO16_RS07370	COG3634	alkyl hydroperoxide reductase activity
HKO16_RS07405	COG1301	dicarboxylic acid transport
HKO16_RS07410	COG0436	Aminotransferase
HKO16_RS07420	COG0386	Belongs to the glutathione peroxidase family
HKO16_RS07460	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HKO16_RS07485	COG0012	GTP binding
HKO16_RS07490	COG2011	ABC-type metal ion transport system permease component
HKO16_RS07495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HKO16_RS07505	COG1464	Belongs to the NlpA lipoprotein family
HKO16_RS07535	COG0765	amino acid transport
HKO16_RS07540	COG0765	amino acid transport
HKO16_RS07545	COG1126	abc transporter atp-binding protein
HKO16_RS07555	COG1522	sequence-specific DNA binding
HKO16_RS07570	COG1309	transcriptional regulator
HKO16_RS07590	COG0583	DNA-binding transcription factor activity
HKO16_RS07600	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HKO16_RS07610	COG0697	spore germination
HKO16_RS07635	COG3121	Chaperone
HKO16_RS07640	COG3539	Fimbrial protein
HKO16_RS07665	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HKO16_RS07665	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HKO16_RS07710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HKO16_RS07720	COG2353	YceI-like domain
HKO16_RS07730	COG3698	Phosphodiester glycosidase
HKO16_RS07745	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HKO16_RS07750	COG0506	proline dehydrogenase activity
HKO16_RS07750	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HKO16_RS07750	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HKO16_RS07760	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKO16_RS07765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HKO16_RS07785	COG1132	(ABC) transporter
HKO16_RS07790	COG3122	Protein conserved in bacteria
HKO16_RS07795	COG3619	membrane
HKO16_RS07805	COG0640	Transcriptional regulator
HKO16_RS07815	COG2850	peptidyl-arginine hydroxylation
HKO16_RS07820	COG0424	maF-like protein
HKO16_RS07840	COG0191	fructose-bisphosphate aldolase activity
HKO16_RS07845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HKO16_RS07860	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HKO16_RS07870	COG1192	Involved in chromosome partitioning
HKO16_RS07875	COG1475	DNA binding
HKO16_RS07880	COG0811	peptide transport
HKO16_RS07890	COG1132	(ABC) transporter
HKO16_RS07895	COG1663	tetraacyldisaccharide 4'-kinase activity
HKO16_RS07915	COG0084	hydrolase, TatD family'
HKO16_RS07980	COG0776	regulation of translation
HKO16_RS08010	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HKO16_RS08085	COG0305	Participates in initiation and elongation during chromosome replication
HKO16_RS08175	COG4695	Portal protein
HKO16_RS08280	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HKO16_RS08330	COG0339	signal peptide processing
HKO16_RS08340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKO16_RS08375	COG0702	epimerase
HKO16_RS08380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HKO16_RS08400	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HKO16_RS08430	COG0316	Belongs to the HesB IscA family
HKO16_RS08435	COG0822	iron-sulfur transferase activity
HKO16_RS08460	COG0776	regulation of translation
HKO16_RS08470	COG2207	Transcriptional regulator
HKO16_RS08475	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKO16_RS08480	COG1960	acyl-CoA dehydrogenase activity
HKO16_RS08485	COG1960	acyl-CoA dehydrogenase activity
HKO16_RS08500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HKO16_RS08515	COG2814	Major facilitator Superfamily
HKO16_RS08520	COG4264	IucA IucC family
HKO16_RS08525	COG4264	IucA IucC family
HKO16_RS08535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HKO16_RS08565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HKO16_RS08580	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HKO16_RS08585	COG0406	alpha-ribazole phosphatase activity
HKO16_RS08600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HKO16_RS08605	COG0730	response to heat
HKO16_RS08625	COG4773	Receptor
HKO16_RS08630	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HKO16_RS08645	COG1131	(ABC) transporter
HKO16_RS08650	COG0842	Transport permease protein
HKO16_RS08655	COG0842	Transport permease protein
HKO16_RS08710	COG2226	methyltransferase
HKO16_RS08735	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HKO16_RS08740	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HKO16_RS08770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HKO16_RS08780	COG0133	tryptophan synthase activity
HKO16_RS08795	COG3706	GGDEF domain
HKO16_RS08810	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HKO16_RS08815	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HKO16_RS08820	COG0022	dehydrogenase e1 component
HKO16_RS08825	COG0508	dehydrogenase complex catalyzes the overall conversion of
HKO16_RS08830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKO16_RS08840	COG1063	alcohol dehydrogenase
HKO16_RS08845	COG3781	membrane
HKO16_RS08855	COG3453	Protein conserved in bacteria
HKO16_RS08855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HKO16_RS08865	COG0730	response to heat
HKO16_RS08880	COG2207	Transcriptional regulator
HKO16_RS08880	COG3708	Transcriptional regulator
HKO16_RS08885	COG1733	regulation of RNA biosynthetic process
HKO16_RS08890	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HKO16_RS08900	COG2188	Transcriptional regulator
HKO16_RS08915	COG4521	taurine ABC transporter
HKO16_RS08920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKO16_RS08940	COG0477	Major facilitator Superfamily
HKO16_RS08950	COG1027	Aspartate ammonia-lyase
HKO16_RS08965	COG0583	DNA-binding transcription factor activity
HKO16_RS08970	COG0583	DNA-binding transcription factor activity
HKO16_RS08975	COG0183	Belongs to the thiolase family
HKO16_RS08980	COG2031	fatty acid transporter
HKO16_RS08995	COG0583	DNA-binding transcription factor activity
HKO16_RS09015	COG1309	transcriptional regulator
HKO16_RS09025	COG2610	gluconate transmembrane transporter activity
HKO16_RS09030	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_RS09035	COG2207	Transcriptional regulator
HKO16_RS09050	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_RS09060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HKO16_RS09095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKO16_RS09100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKO16_RS09105	COG0745	RESPONSE REGULATOR receiver
HKO16_RS09110	COG2205	protein histidine kinase activity
HKO16_RS09125	COG2207	Transcriptional regulator
HKO16_RS09175	COG2856	Zn peptidase
HKO16_RS09210	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HKO16_RS09305	COG1120	ATPase activity
HKO16_RS09320	COG1064	alcohol dehydrogenase
HKO16_RS09325	COG2207	Transcriptional regulator
HKO16_RS09330	COG2084	Dehydrogenase
HKO16_RS09340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HKO16_RS09345	COG0583	DNA-binding transcription factor activity
HKO16_RS09355	COG0129	dihydroxy-acid dehydratase activity
HKO16_RS09360	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_RS09375	COG1566	PFAM secretion protein HlyD family protein
HKO16_RS09390	COG0583	DNA-binding transcription factor activity
HKO16_RS09405	COG2188	Transcriptional regulator
HKO16_RS09485	COG0318	PFAM AMP-dependent synthetase and ligase
HKO16_RS09495	COG1960	acyl-CoA dehydrogenase activity
HKO16_RS09505	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_RS09510	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_RS09515	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_RS09520	COG0583	DNA-binding transcription factor activity
HKO16_RS09525	COG1309	transcriptional regulator
HKO16_RS09550	COG0789	Transcriptional regulator
HKO16_RS09560	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HKO16_RS09570	COG0446	pyridine nucleotide-disulphide oxidoreductase
HKO16_RS09570	COG1902	pentaerythritol trinitrate reductase activity
HKO16_RS09585	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_RS09605	COG2186	Transcriptional regulator
HKO16_RS09615	COG0583	DNA-binding transcription factor activity
HKO16_RS09620	COG4948	Mandelate Racemase Muconate Lactonizing
HKO16_RS09625	COG4829	muconolactone delta-isomerase
HKO16_RS09635	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HKO16_RS09640	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HKO16_RS09645	COG0183	Belongs to the thiolase family
HKO16_RS09650	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HKO16_RS09660	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_RS09670	COG3733	amine oxidase
HKO16_RS09680	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HKO16_RS09690	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_RS09700	COG4638	Rieske (2fe-2S)
HKO16_RS09720	COG0154	amidase activity
HKO16_RS09730	COG2814	Major facilitator Superfamily
HKO16_RS09755	COG1960	acyl-CoA dehydrogenase activity
HKO16_RS09760	COG0583	DNA-binding transcription factor activity
HKO16_RS09765	COG1414	Transcriptional regulator
HKO16_RS09780	COG2391	methyltransferase activity
HKO16_RS09790	COG4993	Dehydrogenase
HKO16_RS09795	COG3659	wide pore channel activity
HKO16_RS09800	COG3420	alginic acid biosynthetic process
HKO16_RS09805	COG0710	3-dehydroquinate dehydratase activity
HKO16_RS09810	COG3485	protocatechuate 3,4-dioxygenase
HKO16_RS09815	COG3485	protocatechuate 3,4-dioxygenase
HKO16_RS09820	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKO16_RS09825	COG2271	Major facilitator Superfamily
HKO16_RS09830	COG0596	Alpha beta hydrolase
HKO16_RS09835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HKO16_RS09840	COG0183	Belongs to the thiolase family
HKO16_RS09845	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HKO16_RS09850	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HKO16_RS09860	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HKO16_RS09865	COG2323	membrane
HKO16_RS09910	COG0446	pyridine nucleotide-disulphide oxidoreductase
HKO16_RS09910	COG1902	pentaerythritol trinitrate reductase activity
HKO16_RS09935	COG0542	response to heat
HKO16_RS09940	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HKO16_RS09970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HKO16_RS09975	COG0569	domain protein
HKO16_RS09980	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HKO16_RS09995	COG4774	siderophore transport
HKO16_RS10000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKO16_RS10010	COG1585	Membrane protein implicated in regulation of membrane protease activity
HKO16_RS10025	COG1294	oxidase, subunit
HKO16_RS10030	COG4890	Cyd operon protein YbgT
HKO16_RS10045	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HKO16_RS10055	COG0552	protein localization to endoplasmic reticulum
HKO16_RS10080	COG0516	GMP reductase activity
HKO16_RS10080	COG0517	IMP dehydrogenase activity
HKO16_RS10085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HKO16_RS10090	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HKO16_RS10100	COG0583	DNA-binding transcription factor activity
HKO16_RS10105	COG0024	Methionine aminopeptidase
HKO16_RS10135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKO16_RS10135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKO16_RS10140	COG1105	Belongs to the carbohydrate kinase PfkB family
HKO16_RS10145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKO16_RS10145	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HKO16_RS10145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKO16_RS10160	COG5001	Diguanylate cyclase
HKO16_RS10160	COG3300	MHYT domain
HKO16_RS10175	COG2135	peptidase activity
HKO16_RS10180	COG0659	secondary active sulfate transmembrane transporter activity
HKO16_RS10195	COG1113	amino acid transport
HKO16_RS10205	COG1522	sequence-specific DNA binding
HKO16_RS10230	COG1011	Hydrolase
HKO16_RS10235	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HKO16_RS10245	COG2137	regulation of response to DNA damage stimulus
HKO16_RS10260	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HKO16_RS10280	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HKO16_RS10295	COG0575	Belongs to the CDS family
HKO16_RS10300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HKO16_RS10325	COG3852	Histidine kinase
HKO16_RS10330	COG2204	response regulator
HKO16_RS10385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HKO16_RS10390	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HKO16_RS10410	COG0697	spore germination
HKO16_RS10415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKO16_RS10425	COG0303	'Molybdopterin
HKO16_RS10430	COG0315	cyclic pyranopterin monophosphate synthase activity
HKO16_RS10430	COG0521	Mo-molybdopterin cofactor biosynthetic process
HKO16_RS10445	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HKO16_RS10450	COG0243	molybdopterin cofactor binding
HKO16_RS10460	COG0243	molybdopterin cofactor binding
HKO16_RS10465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKO16_RS10470	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKO16_RS10470	COG2146	nitrite reductase [NAD(P)H] activity
HKO16_RS10480	COG0745	RESPONSE REGULATOR receiver
HKO16_RS10485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKO16_RS10485	COG1116	anion transmembrane transporter activity
HKO16_RS10505	COG0511	ligase activity, forming carbon-carbon bonds
HKO16_RS10520	COG2814	Major facilitator Superfamily
HKO16_RS10535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HKO16_RS10605	COG1598	PFAM Uncharacterised protein family UPF0150
HKO16_RS10710	COG5410	chromosome segregation
HKO16_RS10750	COG3617	BRO family, N-terminal domain
HKO16_RS10895	COG0069	glutamate synthase activity
HKO16_RS10915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HKO16_RS10925	COG1454	alcohol dehydrogenase
HKO16_RS10930	COG0824	Thioesterase
HKO16_RS10940	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HKO16_RS10960	COG2030	dehydratase
HKO16_RS10970	COG0183	Belongs to the thiolase family
HKO16_RS10980	COG0583	DNA-binding transcription factor activity
HKO16_RS10985	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HKO16_RS10995	COG1522	sequence-specific DNA binding
HKO16_RS11000	COG3135	benzoate transporter
HKO16_RS11010	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HKO16_RS11035	COG0589	response to stress
HKO16_RS11040	COG0488	(ABC) transporter
HKO16_RS11060	COG4773	Receptor
HKO16_RS11090	COG0668	transmembrane transport
HKO16_RS11100	COG1309	transcriptional regulator
HKO16_RS11115	COG1605	Chorismate mutase
HKO16_RS11155	COG0308	aminopeptidase N
HKO16_RS11180	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HKO16_RS11185	COG1454	alcohol dehydrogenase
HKO16_RS11205	COG0531	amino acid
HKO16_RS11210	COG4303	Ethanolamine ammonia lyase large subunit
HKO16_RS11215	COG4302	ethanolamine ammonia-lyase activity
HKO16_RS11220	COG0519	Catalyzes the synthesis of GMP from XMP
HKO16_RS11220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HKO16_RS11225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HKO16_RS11250	COG0697	spore germination
HKO16_RS11255	COG1923	regulation of RNA biosynthetic process
HKO16_RS11265	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HKO16_RS11270	COG0802	atpase or kinase
HKO16_RS11290	COG1187	pseudouridine synthase activity
HKO16_RS11305	COG0583	DNA-binding transcription factor activity
HKO16_RS11320	COG2814	Major facilitator Superfamily
HKO16_RS11325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HKO16_RS11350	COG0729	surface antigen
HKO16_RS11370	COG0174	glutamine synthetase
HKO16_RS11375	COG0745	RESPONSE REGULATOR receiver
HKO16_RS11380	COG2205	protein histidine kinase activity
HKO16_RS11385	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HKO16_RS11390	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HKO16_RS11395	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HKO16_RS11405	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HKO16_RS11420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HKO16_RS11425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HKO16_RS11430	COG1960	acyl-CoA dehydrogenase activity
HKO16_RS11460	COG0583	DNA-binding transcription factor activity
HKO16_RS11475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKO16_RS11485	COG3658	cytochrome
HKO16_RS11490	COG1215	transferase activity, transferring glycosyl groups
HKO16_RS11495	COG1649	PFAM Uncharacterised BCR, COG1649
HKO16_RS11495	COG0726	polysaccharide deacetylase
HKO16_RS11520	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HKO16_RS11525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HKO16_RS11535	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HKO16_RS11560	COG0305	Participates in initiation and elongation during chromosome replication
HKO16_RS11565	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HKO16_RS11575	COG1305	Transglutaminase-like
HKO16_RS11585	COG2308	Evidence 4 Homologs of previously reported genes of
HKO16_RS11615	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HKO16_RS11620	COG0138	bifunctional purine biosynthesis protein purh
HKO16_RS11625	COG0151	Belongs to the GarS family
HKO16_RS11630	COG1464	Belongs to the NlpA lipoprotein family
HKO16_RS11635	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HKO16_RS11640	COG2011	ABC-type metal ion transport system permease component
HKO16_RS11645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HKO16_RS11655	COG1301	dicarboxylic acid transport
HKO16_RS11685	COG1794	racemase activity, acting on amino acids and derivatives
HKO16_RS11700	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HKO16_RS11700	COG3008	intermembrane lipid transfer
HKO16_RS11705	COG2995	paraquat-inducible protein a
HKO16_RS11735	COG1051	belongs to the nudix hydrolase family
HKO16_RS11740	COG0477	Major facilitator Superfamily
HKO16_RS11790	COG2186	Transcriptional regulator
HKO16_RS11800	COG0786	glutamate:sodium symporter activity
HKO16_RS11805	COG3243	poly(R)-hydroxyalkanoic acid synthase
HKO16_RS11830	COG3111	PFAM Bacterial OB fold (BOF) protein
HKO16_RS11900	COG0515	serine threonine protein kinase
HKO16_RS11900	COG2815	serine threonine protein kinase
HKO16_RS11930	COG1610	YqeY-like protein
HKO16_RS11935	COG4783	chaperone-mediated protein folding
HKO16_RS11960	COG1286	toxin biosynthetic process
HKO16_RS11990	COG0778	Nitroreductase
HKO16_RS12000	COG0513	Belongs to the DEAD box helicase family
HKO16_RS12020	COG2363	Small membrane protein
HKO16_RS12050	COG4650	regulator
HKO16_RS12055	COG1234	tRNA 3'-trailer cleavage
HKO16_RS12060	COG1690	Belongs to the RtcB family
HKO16_RS12080	COG2195	Cleaves the N-terminal amino acid of tripeptides
HKO16_RS12090	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HKO16_RS12100	COG2819	hydrolase of the alpha beta superfamily
HKO16_RS12105	COG1960	acyl-CoA dehydrogenase activity
HKO16_RS12110	COG1301	dicarboxylic acid transport
HKO16_RS12115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HKO16_RS12120	COG3139	Protein of unknown function (DUF1315)
HKO16_RS12125	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HKO16_RS12130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HKO16_RS12140	COG0494	nUDIX hydrolase
HKO16_RS12150	COG0642	Histidine kinase
HKO16_RS12155	COG0745	RESPONSE REGULATOR receiver
HKO16_RS12175	COG1720	tRNA m6t6A37 methyltransferase activity
HKO16_RS12190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKO16_RS12200	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HKO16_RS12210	COG4598	ABC transporter
HKO16_RS12215	COG4160	amino acid transport
HKO16_RS12220	COG4215	(ABC) transporter
HKO16_RS12235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKO16_RS12280	COG1131	(ABC) transporter
HKO16_RS12285	COG0842	Transport permease protein
HKO16_RS12300	COG0772	Belongs to the SEDS family
HKO16_RS12305	COG2951	lytic endotransglycosylase activity
HKO16_RS12330	COG2207	Transcriptional regulator
HKO16_RS12345	COG0052	Belongs to the universal ribosomal protein uS2 family
HKO16_RS12350	COG0024	Methionine aminopeptidase
HKO16_RS12360	COG2223	nitrite transmembrane transporter activity
HKO16_RS12370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKO16_RS12375	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HKO16_RS12380	COG1960	acyl-CoA dehydrogenase activity
HKO16_RS12395	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HKO16_RS12400	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HKO16_RS12405	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HKO16_RS12425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKO16_RS12430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HKO16_RS12435	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HKO16_RS12470	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HKO16_RS12480	COG0174	glutamine synthetase
HKO16_RS12485	COG3104	oligopeptide transport
HKO16_RS12495	COG0512	Glutamine amidotransferase of anthranilate synthase
HKO16_RS12500	COG0308	aminopeptidase N
HKO16_RS12530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HKO16_RS12560	COG3739	integral membrane protein
HKO16_RS12585	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HKO16_RS12595	COG1132	(ABC) transporter
HKO16_RS12605	COG1535	isochorismatase
HKO16_RS12605	COG3433	isochorismatase activity
HKO16_RS12610	COG1021	2,3-dihydroxybenzoate-AMP ligase
HKO16_RS12615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKO16_RS12625	COG4774	siderophore transport
HKO16_RS12630	COG4607	ABC-type enterochelin transport system periplasmic component
HKO16_RS12635	COG4604	ABC transporter, ATP-binding protein
HKO16_RS12640	COG4605	iron ion homeostasis
HKO16_RS12645	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKO16_RS12650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKO16_RS12665	COG2964	Protein conserved in bacteria
HKO16_RS12675	COG1741	Belongs to the pirin family
HKO16_RS12715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HKO16_RS12725	COG0596	Alpha beta hydrolase
HKO16_RS12740	COG0583	DNA-binding transcription factor activity
HKO16_RS12745	COG1335	isochorismatase
HKO16_RS12785	COG2879	small protein
HKO16_RS12790	COG1966	Carbon starvation protein
HKO16_RS12810	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HKO16_RS12835	COG1067	ATP-dependent peptidase activity
HKO16_RS12840	COG0583	DNA-binding transcription factor activity
HKO16_RS12865	COG1686	Belongs to the peptidase S11 family
HKO16_RS12870	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HKO16_RS12905	COG0616	signal peptide processing
HKO16_RS12910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HKO16_RS12920	COG0573	inorganic phosphate transmembrane transporter activity
HKO16_RS12925	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HKO16_RS12930	COG1113	amino acid transport
HKO16_RS12935	COG3961	Belongs to the TPP enzyme family
HKO16_RS12940	COG1522	sequence-specific DNA binding
HKO16_RS12950	COG0076	glutamate decarboxylase activity
HKO16_RS12955	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HKO16_RS12970	COG2249	NAD(P)H dehydrogenase (quinone) activity
HKO16_RS12980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HKO16_RS13015	COG0352	thiamine-phosphate diphosphorylase activity
HKO16_RS13040	COG0612	Peptidase, M16
HKO16_RS13055	COG0583	DNA-binding transcription factor activity
HKO16_RS13060	COG0477	Major facilitator Superfamily
HKO16_RS13085	COG1187	pseudouridine synthase activity
HKO16_RS13100	COG1686	Belongs to the peptidase S11 family
HKO16_RS13105	COG1252	NADH dehydrogenase
HKO16_RS13115	COG0415	Belongs to the DNA photolyase family
HKO16_RS13130	COG1215	transferase activity, transferring glycosyl groups
HKO16_RS13160	COG2070	2-Nitropropane dioxygenase
HKO16_RS13215	COG0556	nucleotide-excision repair
HKO16_RS13235	COG0436	Aminotransferase
HKO16_RS13245	COG0443	Heat shock 70 kDa protein
HKO16_RS13275	COG4221	oxidoreductase activity
HKO16_RS13285	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HKO16_RS13290	COG1381	Involved in DNA repair and RecF pathway recombination
HKO16_RS13300	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HKO16_RS13315	COG0681	Belongs to the peptidase S26 family
HKO16_RS13325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HKO16_RS13335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKO16_RS13355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HKO16_RS13360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HKO16_RS13365	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HKO16_RS13375	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HKO16_RS13380	COG4208	sulfate ABC transporter
HKO16_RS13385	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HKO16_RS13390	COG0583	DNA-binding transcription factor activity
HKO16_RS13395	COG4625	pathogenesis
HKO16_RS13410	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HKO16_RS13425	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HKO16_RS13435	COG1056	cytidyltransferase-related domain
HKO16_RS13435	COG1051	belongs to the nudix hydrolase family
HKO16_RS13440	COG1024	Enoyl-CoA hydratase
HKO16_RS13510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKO16_RS13520	COG0534	Mate efflux family protein
HKO16_RS13535	COG4774	siderophore transport
HKO16_RS13540	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HKO16_RS13560	COG0019	diaminopimelate decarboxylase activity
HKO16_RS13565	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HKO16_RS13570	COG1021	2,3-dihydroxybenzoate-AMP ligase
HKO16_RS13575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKO16_RS13580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKO16_RS13580	COG2226	methyltransferase
HKO16_RS13580	COG3433	isochorismatase activity
HKO16_RS13585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKO16_RS13590	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_RS13595	COG3433	isochorismatase activity
HKO16_RS13595	COG1535	isochorismatase
HKO16_RS13600	COG1169	isochorismate synthase
HKO16_RS13625	COG0047	phosphoribosylformylglycinamidine synthase activity
HKO16_RS13625	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HKO16_RS13645	COG1473	amidohydrolase
HKO16_RS13650	COG0824	Thioesterase
HKO16_RS13670	COG0823	Involved in the tonB-independent uptake of proteins
HKO16_RS13690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HKO16_RS13725	COG0628	permease
HKO16_RS13735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HKO16_RS13740	COG0596	Alpha beta hydrolase
HKO16_RS13745	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HKO16_RS13745	COG0616	signal peptide processing
HKO16_RS13755	COG2333	competence protein COMEC
HKO16_RS13755	COG0658	competence protein
HKO16_RS13760	COG1136	(ABC) transporter
HKO16_RS13765	COG4591	ABC-type transport system involved in lipoprotein release permease component
HKO16_RS13800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKO16_RS13820	COG0463	Glycosyl transferase, family 2
HKO16_RS13850	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HKO16_RS13855	COG1280	lysine exporter protein (LysE YggA)
HKO16_RS13865	COG0019	diaminopimelate decarboxylase activity
HKO16_RS13875	COG1113	amino acid transport
HKO16_RS13890	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HKO16_RS13900	COG3339	Conserved Protein
HKO16_RS13905	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HKO16_RS13910	COG0243	molybdopterin cofactor binding
HKO16_RS13915	COG1929	Belongs to the glycerate kinase type-1 family
HKO16_RS13930	COG0778	Nitroreductase
HKO16_RS13985	COG3811	Belongs to the UPF0386 family
HKO16_RS13995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKO16_RS14010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HKO16_RS14030	COG0741	lytic transglycosylase activity
HKO16_RS14050	COG0584	glycerophosphoryl diester phosphodiesterase
HKO16_RS14055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HKO16_RS14075	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HKO16_RS14080	COG1597	lipid kinase activity
HKO16_RS14095	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HKO16_RS14100	COG0477	Major facilitator Superfamily
HKO16_RS14150	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HKO16_RS14155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HKO16_RS14180	COG0505	Belongs to the CarA family
HKO16_RS14195	COG1309	transcriptional regulator
HKO16_RS14200	COG0251	oxidation-reduction process
HKO16_RS14210	COG0589	response to stress
HKO16_RS14225	COG2843	Capsule synthesis protein
HKO16_RS14245	COG2321	neutral zinc metallopeptidase
HKO16_RS14250	COG2354	Protein conserved in bacteria
HKO16_RS14270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKO16_RS14295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HKO16_RS14300	COG1053	succinate dehydrogenase
HKO16_RS14305	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HKO16_RS14310	COG2009	succinate dehydrogenase
HKO16_RS14350	COG2921	Belongs to the UPF0250 family
HKO16_RS14355	COG0321	lipoyl(octanoyl) transferase activity
HKO16_RS14370	COG0531	amino acid
HKO16_RS14380	COG1733	regulation of RNA biosynthetic process
HKO16_RS14385	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HKO16_RS14390	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HKO16_RS14390	COG1648	precorrin-2 dehydrogenase activity
HKO16_RS14405	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HKO16_RS14435	COG0671	phosphoesterase, PA-phosphatase related
HKO16_RS14440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKO16_RS14450	COG1538	Outer membrane efflux protein
HKO16_RS14455	COG0393	Putative heavy-metal-binding
HKO16_RS14460	COG0393	Putative heavy-metal-binding
HKO16_RS14470	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_RS14480	COG0525	valine-tRNA ligase activity
HKO16_RS14500	COG0583	DNA-binding transcription factor activity
HKO16_RS14505	COG0004	ammonium transporteR
HKO16_RS14515	COG0642	Histidine kinase
HKO16_RS14520	COG0745	RESPONSE REGULATOR receiver
HKO16_RS14525	COG2194	sulfuric ester hydrolase activity
HKO16_RS14545	COG1752	Esterase of the alpha-beta hydrolase superfamily
HKO16_RS14560	COG2315	Protein conserved in bacteria
HKO16_RS14565	COG0142	geranyltranstransferase activity
HKO16_RS14570	COG2828	Protein conserved in bacteria
HKO16_RS14575	COG1113	amino acid transport
HKO16_RS14595	COG2207	Transcriptional regulator
HKO16_RS14620	COG2249	NAD(P)H dehydrogenase (quinone) activity
HKO16_RS14630	COG0560	Phosphoserine phosphatase
HKO16_RS14640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKO16_RS14650	COG1530	ribonuclease E activity
HKO16_RS14655	COG0424	maF-like protein
HKO16_RS14660	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HKO16_RS14665	COG1792	Involved in formation and maintenance of cell shape
HKO16_RS14670	COG1077	Cell shape determining protein MreB Mrl
HKO16_RS14675	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HKO16_RS14685	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HKO16_RS14710	COG3590	peptidase
HKO16_RS14715	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HKO16_RS14720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HKO16_RS14725	COG1752	Esterase of the alpha-beta hydrolase superfamily
HKO16_RS14730	COG1115	amino acid carrier protein
HKO16_RS14750	COG2814	Major facilitator Superfamily
HKO16_RS14755	COG1289	transmembrane transporter activity
HKO16_RS14765	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HKO16_RS14805	COG1376	ErfK ybiS ycfS ynhG family protein
HKO16_RS14810	COG2832	Protein of unknown function (DUF454)
HKO16_RS14820	COG5510	response to toxic substance
HKO16_RS14840	COG0840	transmembrane signaling receptor activity
HKO16_RS14880	COG3422	double-strand break repair
HKO16_RS14885	COG2824	Alkylphosphonate utilization operon protein PhnA
HKO16_RS14890	COG3189	MarR family transcriptional regulator
HKO16_RS14900	COG0354	folic acid binding
HKO16_RS14905	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HKO16_RS14920	COG1902	pentaerythritol trinitrate reductase activity
HKO16_RS14925	COG4772	TonB-dependent receptor
HKO16_RS14930	COG2094	Belongs to the DNA glycosylase MPG family
HKO16_RS14960	COG2233	PERMEase
HKO16_RS14970	COG0833	amino acid
HKO16_RS14975	COG1690	Belongs to the RtcB family
HKO16_RS14995	COG0183	Belongs to the thiolase family
HKO16_RS15015	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKO16_RS15035	COG2207	Transcriptional regulator
HKO16_RS15040	COG0183	Belongs to the thiolase family
HKO16_RS15060	COG2153	protein acetylation
HKO16_RS15070	COG1272	protein, Hemolysin III
HKO16_RS15075	COG0477	Major facilitator Superfamily
HKO16_RS15090	COG0450	alkyl hydroperoxide reductase
HKO16_RS15110	COG0285	dihydrofolate synthase activity
HKO16_RS15155	COG4206	TonB-dependent receptor
HKO16_RS15160	COG2096	Adenosyltransferase
HKO16_RS15180	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HKO16_RS15185	COG0745	RESPONSE REGULATOR receiver
HKO16_RS15190	COG2205	protein histidine kinase activity
HKO16_RS15200	COG1960	acyl-CoA dehydrogenase activity
HKO16_RS15205	COG1960	acyl-CoA dehydrogenase activity
HKO16_RS15255	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HKO16_RS15270	COG0438	transferase activity, transferring glycosyl groups
HKO16_RS15275	COG0463	Glycosyl transferase, family 2
HKO16_RS15280	COG0726	polysaccharide deacetylase
HKO16_RS15300	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HKO16_RS15305	COG2205	protein histidine kinase activity
HKO16_RS15320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HKO16_RS15345	COG0582	viral genome integration into host DNA
HKO16_RS15375	COG1862	Preprotein translocase
HKO16_RS15385	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HKO16_RS15390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HKO16_RS15400	COG3781	membrane
HKO16_RS15405	COG0613	PHP domain protein
HKO16_RS15415	COG2350	Protein conserved in bacteria
HKO16_RS15440	COG0582	viral genome integration into host DNA
HKO16_RS15490	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKO16_RS15515	COG2132	Multicopper oxidase
HKO16_RS15530	COG2205	protein histidine kinase activity
HKO16_RS15610	COG3013	Belongs to the UPF0304 family
HKO16_RS15645	COG1607	acyl-coa hydrolase
HKO16_RS15705	COG2199	diguanylate cyclase activity
HKO16_RS15715	COG1408	metallophosphoesterase
HKO16_RS15720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKO16_RS15730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HKO16_RS15750	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HKO16_RS15755	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HKO16_RS15760	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HKO16_RS15770	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HKO16_RS15780	COG2969	positive regulation of protein catabolic process
HKO16_RS15800	COG1960	acyl-CoA dehydrogenase activity
HKO16_RS15805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HKO16_RS15820	COG1309	transcriptional regulator
HKO16_RS15825	COG1960	acyl-CoA dehydrogenase activity
HKO16_RS15870	COG1183	phosphatidylcholine synthase activity
HKO16_RS15875	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HKO16_RS15905	COG1196	nuclear chromosome segregation
HKO16_RS15905	COG0739	heme binding
HKO16_RS15905	COG0741	lytic transglycosylase activity
HKO16_RS15915	COG1702	phosphate starvation-inducible protein PhoH
HKO16_RS15950	COG1295	ribonuclease BN
HKO16_RS15955	COG0697	spore germination
HKO16_RS15960	COG2169	Transcriptional regulator
HKO16_RS15965	COG0179	Fumarylacetoacetate (FAA) hydrolase
HKO16_RS16010	COG0557	exoribonuclease II activity
HKO16_RS16015	COG0339	signal peptide processing
HKO16_RS16020	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HKO16_RS16050	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HKO16_RS16055	COG1960	acyl-CoA dehydrogenase activity
HKO16_RS16210	COG0626	cystathionine gamma-synthase activity
HKO16_RS16215	COG0433	COG0433 Predicted ATPase
HKO16_RS16225	COG1017	nitric oxide dioxygenase activity
HKO16_RS16225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HKO16_RS16230	COG1959	2 iron, 2 sulfur cluster binding
HKO16_RS16245	COG1301	dicarboxylic acid transport
HKO16_RS16250	COG1946	Acyl-CoA thioesterase
HKO16_RS16270	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HKO16_RS16275	COG1040	competence protein
HKO16_RS16280	COG0494	nUDIX hydrolase
HKO16_RS16290	COG0598	Magnesium transport protein CorA
HKO16_RS16300	COG2854	intermembrane phospholipid transfer
HKO16_RS16310	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HKO16_RS16315	COG1127	ABC transporter
HKO16_RS16325	COG0513	Belongs to the DEAD box helicase family
HKO16_RS16345	COG0408	coproporphyrinogen oxidase activity
HKO16_RS16360	COG1960	acyl-CoA dehydrogenase activity
HKO16_RS16370	COG1983	PspC domain protein
HKO16_RS16375	COG0517	IMP dehydrogenase activity
HKO16_RS16425	COG0583	DNA-binding transcription factor activity
HKO16_RS16465	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_RS16475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HKO16_RS16480	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HKO16_RS16485	COG0833	amino acid
HKO16_RS16515	COG1192	Involved in chromosome partitioning
HKO16_RS16520	COG0628	permease
HKO16_RS16530	COG1289	transmembrane transporter activity
HKO16_RS16545	COG2249	NAD(P)H dehydrogenase (quinone) activity
HKO16_RS16550	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HKO16_RS16560	COG0277	FAD linked oxidase domain protein
HKO16_RS16565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HKO16_RS16590	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HKO16_RS16595	COG5380	lipid catabolic process
HKO16_RS16615	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HKO16_RS16665	COG0194	GDP metabolic process
HKO16_RS16680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HKO16_RS16700	COG3307	-O-antigen
HKO16_RS16705	COG4969	Belongs to the N-Me-Phe pilin family
HKO16_RS16715	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HKO16_RS16720	COG1704	LemA family
HKO16_RS16730	COG0493	'glutamate synthase
HKO16_RS16735	COG0069	glutamate synthase activity
HKO16_RS16735	COG0067	glutamate synthase
HKO16_RS16735	COG0070	glutamate synthase
HKO16_RS16785	COG2226	methyltransferase
HKO16_RS16800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HKO16_RS16805	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HKO16_RS16850	COG0833	amino acid
HKO16_RS16915	COG0488	(ABC) transporter
HKO16_RS16940	COG4221	oxidoreductase activity
HKO16_RS16945	COG0659	secondary active sulfate transmembrane transporter activity
HKO16_RS16955	COG0745	RESPONSE REGULATOR receiver
HKO16_RS16970	COG0427	acetyl-CoA hydrolase
HKO16_RS17000	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HKO16_RS17030	COG2329	Antibiotic biosynthesis monooxygenase
HKO16_RS17045	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HKO16_RS17100	COG2207	Transcriptional regulator
HKO16_RS17105	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HKO16_RS17125	COG2249	NAD(P)H dehydrogenase (quinone) activity
HKO16_RS17130	COG1733	regulation of RNA biosynthetic process
HKO16_RS17160	COG1733	regulation of RNA biosynthetic process
HKO16_RS17205	COG0583	DNA-binding transcription factor activity
HKO16_RS17210	COG2814	Major facilitator Superfamily
HKO16_RS17250	COG1335	isochorismatase
HKO16_RS17260	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_RS17265	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HKO16_RS17275	COG1113	amino acid transport
HKO16_RS17285	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HKO16_RS17300	COG2814	Major facilitator Superfamily
HKO16_RS17310	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HKO16_RS17310	COG0352	thiamine-phosphate diphosphorylase activity
HKO16_RS17310	COG0351	phosphomethylpyrimidine kinase
HKO16_RS17330	COG1309	transcriptional regulator
HKO16_RS17335	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HKO16_RS17340	COG3706	GGDEF domain
HKO16_RS17350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HKO16_RS17360	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKO16_RS17365	COG3162	membrane
HKO16_RS17370	COG0784	Response regulator, receiver
HKO16_RS17370	COG2205	protein histidine kinase activity
HKO16_RS17370	COG2198	Histidine kinase
HKO16_RS17395	COG1522	sequence-specific DNA binding
HKO16_RS17400	COG1335	isochorismatase
HKO16_RS17405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HKO16_RS17415	COG0668	transmembrane transport
HKO16_RS17425	COG1519	Transferase
HKO16_RS17430	COG1902	pentaerythritol trinitrate reductase activity
HKO16_RS17450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HKO16_RS17475	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HKO16_RS17475	COG0426	domain, Protein
HKO16_RS17480	COG4774	siderophore transport
HKO16_RS17485	COG2119	membrane
HKO16_RS17495	COG0508	dehydrogenase complex catalyzes the overall conversion of
HKO16_RS17505	COG4942	peptidase
HKO16_RS17520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HKO16_RS17530	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HKO16_RS17550	COG0189	ligase activity
HKO16_RS17575	COG0708	Exodeoxyribonuclease III
HKO16_RS17580	COG1393	Belongs to the ArsC family
HKO16_RS17595	COG3706	GGDEF domain
HKO16_RS17630	COG2351	hydroxyisourate hydrolase activity
HKO16_RS17635	COG2233	PERMEase
HKO16_RS17645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKO16_RS17655	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HKO16_RS17665	COG3150	esterase
HKO16_RS17700	COG1705	Flagellar rod assembly protein muramidase FlgJ
HKO16_RS17700	COG1388	LysM domain
HKO16_RS17740	COG4691	Plasmid stability protein
HKO16_RS17775	COG0798	PFAM Bile acid sodium symporter
HKO16_RS17860	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HKO16_RS17890	COG0659	secondary active sulfate transmembrane transporter activity
HKO16_RS17895	COG0589	response to stress
HKO16_RS17945	COG0606	chelatase, subunit chli
HKO16_RS17950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKO16_RS17960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKO16_RS17975	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HKO16_RS17990	COG0318	PFAM AMP-dependent synthetase and ligase
HKO16_RS18000	COG0477	Major facilitator Superfamily
HKO16_RS18005	COG2860	membrane
HKO16_RS18010	COG3012	SEC-C Motif Domain Protein
HKO16_RS18015	COG1253	flavin adenine dinucleotide binding
HKO16_RS18025	COG0477	Major facilitator Superfamily
HKO16_RS18035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HKO16_RS18070	COG0655	NAD(P)H dehydrogenase (quinone) activity
HKO16_RS18080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HKO16_RS18115	COG1309	transcriptional regulator
HKO16_RS18150	COG0758	DNA mediated transformation
HKO16_RS18160	COG0697	spore germination
HKO16_RS18165	COG1309	transcriptional regulator
HKO16_RS18180	COG0386	Belongs to the glutathione peroxidase family
HKO16_RS18250	COG1121	(ABC) transporter
HKO16_RS18255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HKO16_RS18260	COG1280	lysine exporter protein (LysE YggA)
HKO16_RS18265	COG2837	iron assimilation
HKO16_RS18270	COG0281	malic enzyme
HKO16_RS18315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HKO16_RS18315	COG0519	Catalyzes the synthesis of GMP from XMP
HKO16_RS18320	COG4399	Belongs to the UPF0754 family
HKO16_RS18325	COG2259	Doxx family
HKO16_RS18330	COG0586	Pfam SNARE associated Golgi protein
HKO16_RS18345	COG1192	Involved in chromosome partitioning
HKO16_RS18355	COG0271	Belongs to the BolA IbaG family
HKO16_RS18395	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HKO16_RS18395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKO16_RS18395	COG3321	synthase
HKO16_RS18395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HKO16_RS18400	COG1960	acyl-CoA dehydrogenase activity
HKO16_RS18405	COG0318	PFAM AMP-dependent synthetase and ligase
HKO16_RS18410	COG2197	response regulator
HKO16_RS18420	COG3916	Acyl-homoserine-lactone synthase
HKO16_RS18425	COG0477	Major facilitator Superfamily
HKO16_RS18430	COG1024	Enoyl-CoA hydratase
HKO16_RS18435	COG1024	Enoyl-CoA hydratase
HKO16_RS18440	COG1960	acyl-CoA dehydrogenase activity
HKO16_RS18445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HKO16_RS18465	COG1113	amino acid transport
HKO16_RS18470	COG1113	amino acid transport
HKO16_RS18475	COG0251	oxidation-reduction process
HKO16_RS18515	COG0564	pseudouridine synthase activity
HKO16_RS18595	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HKO16_RS18610	COG1802	Transcriptional regulator
HKO16_RS18620	COG1448	Aminotransferase
HKO16_RS18625	COG0277	FAD linked oxidase domain protein
HKO16_RS18635	COG2186	Transcriptional regulator
HKO16_RS18645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKO16_RS18650	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HKO16_RS18665	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HKO16_RS18670	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HKO16_RS18695	COG0438	transferase activity, transferring glycosyl groups
HKO16_RS18725	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HKO16_RS18755	COG0728	peptidoglycan biosynthetic process
HKO16_RS18760	COG3023	N-Acetylmuramoyl-L-alanine amidase
HKO16_RS18820	COG0546	phosphoglycolate phosphatase activity
HKO16_RS18825	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_RS18845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKO16_RS18850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKO16_RS18855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKO16_RS18860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKO16_RS18865	COG1116	anion transmembrane transporter activity
HKO16_RS18870	COG1309	transcriptional regulator
HKO16_RS18875	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HKO16_RS18885	COG0196	riboflavin kinase activity
HKO16_RS18890	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HKO16_RS18900	COG1047	Peptidyl-prolyl cis-trans
HKO16_RS18940	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HKO16_RS18995	COG2951	lytic endotransglycosylase activity
HKO16_RS19000	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HKO16_RS19015	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HKO16_RS19025	COG0671	phosphoesterase, PA-phosphatase related
HKO16_RS19030	COG0861	Integral membrane protein TerC family
HKO16_RS19040	COG0754	glutathionylspermidine amidase activity
HKO16_RS19050	COG0402	S-adenosylhomocysteine deaminase activity
HKO16_RS19065	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HKO16_RS19070	COG1230	cation diffusion facilitator family transporter
HKO16_RS19085	COG0706	membrane insertase activity
HKO16_RS19115	COG0583	DNA-binding transcription factor activity
HKO16_RS19150	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
HKO16_RS19210	COG3077	Addiction module antitoxin, RelB DinJ family
HKO16_RS19225	COG1028	Short-chain dehydrogenase reductase Sdr