locus-tag	class	description
H0N28_RS00010	COG0592	DNA-directed DNA polymerase activity
H0N28_RS00020	COG0187	DNA topoisomerase II activity
H0N28_RS00030	COG0586	Pfam SNARE associated Golgi protein
H0N28_RS00035	COG0488	(ABC) transporter
H0N28_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H0N28_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H0N28_RS00110	COG0733	neurotransmitter:sodium symporter activity
H0N28_RS00150	COG2233	PERMEase
H0N28_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0N28_RS00200	COG2814	Major facilitator Superfamily
H0N28_RS00205	COG0656	L-ascorbic acid biosynthetic process
H0N28_RS00210	COG0583	DNA-binding transcription factor activity
H0N28_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0N28_RS00230	COG1064	alcohol dehydrogenase
H0N28_RS00235	COG2818	Glycosylase
H0N28_RS00250	COG1194	a g-specific adenine glycosylase
H0N28_RS00270	COG2983	Belongs to the UPF0260 family
H0N28_RS00275	COG2133	pyrroloquinoline quinone binding
H0N28_RS00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H0N28_RS00285	COG2116	formate transmembrane transporter activity
H0N28_RS00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0N28_RS00310	COG1335	isochorismatase
H0N28_RS00315	COG0385	Bile acid
H0N28_RS00320	COG0534	Mate efflux family protein
H0N28_RS00325	COG1683	Conserved Protein
H0N28_RS00345	COG0625	glutathione transferase activity
H0N28_RS00355	COG1113	amino acid transport
H0N28_RS00365	COG0523	cobalamin synthesis protein
H0N28_RS00375	COG2188	Transcriptional regulator
H0N28_RS00405	COG0010	Belongs to the arginase family
H0N28_RS00425	COG1280	lysine exporter protein (LysE YggA)
H0N28_RS00440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H0N28_RS00450	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H0N28_RS00455	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H0N28_RS00500	COG0753	catalase activity
H0N28_RS00550	COG0534	Mate efflux family protein
H0N28_RS00555	COG0436	Aminotransferase
H0N28_RS00560	COG2733	membrane
H0N28_RS00575	COG2918	glutathione biosynthetic process
H0N28_RS00610	COG0640	Transcriptional regulator
H0N28_RS00635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H0N28_RS00705	COG1525	nuclease
H0N28_RS00825	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H0N28_RS00875	COG1192	Involved in chromosome partitioning
H0N28_RS00890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H0N28_RS00920	COG0739	heme binding
H0N28_RS01100	COG0501	Belongs to the peptidase M48B family
H0N28_RS01160	COG0589	response to stress
H0N28_RS01165	COG0659	secondary active sulfate transmembrane transporter activity
H0N28_RS01175	COG0606	chelatase, subunit chli
H0N28_RS01185	COG0347	Belongs to the P(II) protein family
H0N28_RS01190	COG0004	ammonium transporteR
H0N28_RS01200	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0N28_RS01200	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0N28_RS01240	COG0795	lipopolysaccharide-transporting ATPase activity
H0N28_RS01245	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H0N28_RS01250	COG0793	Belongs to the peptidase S41A family
H0N28_RS01265	COG2197	response regulator
H0N28_RS01275	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H0N28_RS01285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0N28_RS01290	COG4974	Belongs to the 'phage' integrase family
H0N28_RS01315	COG0772	Belongs to the SEDS family
H0N28_RS01320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0N28_RS01325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H0N28_RS01330	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H0N28_RS01355	COG0697	spore germination
H0N28_RS01360	COG1538	Outer membrane efflux protein
H0N28_RS01380	COG3275	phosphorelay sensor kinase activity
H0N28_RS01390	COG0181	hydroxymethylbilane synthase activity
H0N28_RS01435	COG1716	ATPase activity
H0N28_RS01440	COG0546	phosphoglycolate phosphatase activity
H0N28_RS01535	COG0596	Alpha beta hydrolase
H0N28_RS01540	COG2056	Na+-H+ antiporter family
H0N28_RS01555	COG0326	Molecular chaperone. Has ATPase activity
H0N28_RS01570	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H0N28_RS01635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H0N28_RS01640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H0N28_RS01640	COG2169	Transcriptional regulator
H0N28_RS01670	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H0N28_RS01680	COG0497	DNA recombination
H0N28_RS01695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0N28_RS01705	COG0237	dephospho-CoA kinase activity
H0N28_RS01750	COG0195	Participates in both transcription termination and antitermination
H0N28_RS01765	COG1320	monovalent cation:proton antiporter activity
H0N28_RS01770	COG2212	antiporter activity
H0N28_RS01775	COG1863	multisubunit Na H antiporter MnhE subunit
H0N28_RS01780	COG0651	ATP synthesis coupled electron transport
H0N28_RS01785	COG1006	Multisubunit Na H antiporter MnhC subunit
H0N28_RS01790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H0N28_RS01790	COG2111	Na H antiporter
H0N28_RS01805	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H0N28_RS01825	COG2226	methyltransferase
H0N28_RS01845	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H0N28_RS01850	COG1074	ATP-dependent DNA helicase activity
H0N28_RS01855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0N28_RS01860	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H0N28_RS01875	COG0598	Magnesium transport protein CorA
H0N28_RS01880	COG0789	Transcriptional regulator
H0N28_RS01885	COG0484	heat shock protein binding
H0N28_RS01900	COG0475	glutathione-regulated potassium exporter activity
H0N28_RS01900	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H0N28_RS01905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H0N28_RS01925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0N28_RS01935	COG4535	Mg2 and Co2 transporter CorC
H0N28_RS01940	COG0425	Belongs to the sulfur carrier protein TusA family
H0N28_RS01950	COG0644	oxidoreductase
H0N28_RS01950	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H0N28_RS01960	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H0N28_RS01975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0N28_RS01980	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H0N28_RS01990	COG0493	'glutamate synthase
H0N28_RS01990	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0N28_RS02015	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0N28_RS02030	COG0534	Mate efflux family protein
H0N28_RS02040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0N28_RS02045	COG1028	Short-chain dehydrogenase reductase Sdr
H0N28_RS02050	COG0583	DNA-binding transcription factor activity
H0N28_RS02065	COG0318	PFAM AMP-dependent synthetase and ligase
H0N28_RS02070	COG1530	ribonuclease E activity
H0N28_RS02080	COG0546	phosphoglycolate phosphatase activity
H0N28_RS02085	COG2378	regulation of single-species biofilm formation
H0N28_RS02090	COG0625	glutathione transferase activity
H0N28_RS02100	COG0583	DNA-binding transcription factor activity
H0N28_RS02155	COG0473	3-isopropylmalate dehydrogenase activity
H0N28_RS02210	COG1301	dicarboxylic acid transport
H0N28_RS02220	COG1560	Kdo2-lipid A biosynthetic process
H0N28_RS02225	COG1280	lysine exporter protein (LysE YggA)
H0N28_RS02230	COG0488	(ABC) transporter
H0N28_RS02235	COG2900	Belongs to the SlyX family
H0N28_RS02245	COG1733	regulation of RNA biosynthetic process
H0N28_RS02270	COG0210	DNA helicase
H0N28_RS02275	COG0724	RNA recognition motif
H0N28_RS02320	COG0788	formyltetrahydrofolate deformylase activity
H0N28_RS02420	COG2813	Specifically methylates the guanine in position
H0N28_RS02420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0N28_RS02430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H0N28_RS02440	COG4774	siderophore transport
H0N28_RS02450	COG0740	serine-type endopeptidase activity
H0N28_RS02470	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H0N28_RS02470	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H0N28_RS02475	COG0857	belongs to the CobB CobQ family
H0N28_RS02475	COG0280	phosphate acetyltransferase
H0N28_RS02480	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H0N28_RS02490	COG0800	Aldolase
H0N28_RS02500	COG3265	gluconokinase activity
H0N28_RS02505	COG1012	belongs to the aldehyde dehydrogenase family
H0N28_RS02515	COG2267	carboxylic ester hydrolase activity
H0N28_RS02530	COG0793	Belongs to the peptidase S41A family
H0N28_RS02565	COG1426	Protein conserved in bacteria
H0N28_RS02610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0N28_RS02620	COG0318	PFAM AMP-dependent synthetase and ligase
H0N28_RS02625	COG1216	Glycosyl transferase, family 2
H0N28_RS02635	COG2986	histidine ammonia-lyase
H0N28_RS02675	COG1028	Short-chain dehydrogenase reductase Sdr
H0N28_RS02680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0N28_RS02700	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H0N28_RS02710	COG1162	GTPase activity
H0N28_RS02715	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H0N28_RS02730	COG1538	Outer membrane efflux protein
H0N28_RS02735	COG1136	(ABC) transporter
H0N28_RS02735	COG0577	efflux transmembrane transporter activity
H0N28_RS02740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0N28_RS02765	COG0028	Belongs to the TPP enzyme family
H0N28_RS02770	COG0440	acetolactate synthase activity
H0N28_RS02820	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H0N28_RS02835	COG0084	hydrolase, TatD family'
H0N28_RS02845	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H0N28_RS02855	COG0583	DNA-binding transcription factor activity
H0N28_RS02865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H0N28_RS02870	COG2814	Major facilitator Superfamily
H0N28_RS02880	COG0697	spore germination
H0N28_RS02910	COG3622	Belongs to the hyi family
H0N28_RS02915	COG2084	Dehydrogenase
H0N28_RS02920	COG1024	Enoyl-CoA hydratase
H0N28_RS02925	COG5002	protein histidine kinase activity
H0N28_RS02925	COG2205	protein histidine kinase activity
H0N28_RS02925	COG0784	Response regulator, receiver
H0N28_RS02945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0N28_RS02955	COG3956	TIGRFAM MazG family protein
H0N28_RS02960	COG1555	photosystem II stabilization
H0N28_RS02965	COG0617	tRNA 3'-terminal CCA addition
H0N28_RS02970	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H0N28_RS02990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0N28_RS02995	COG3028	Belongs to the UPF0307 family
H0N28_RS03000	COG0318	PFAM AMP-dependent synthetase and ligase
H0N28_RS03015	COG0625	glutathione transferase activity
H0N28_RS03020	COG1238	metal cluster binding
H0N28_RS03060	COG0072	phenylalanine-tRNA ligase activity
H0N28_RS03090	COG0248	Ppx GppA phosphatase
H0N28_RS03100	COG0037	tRNA processing
H0N28_RS03140	COG1764	response to oxidative stress
H0N28_RS03145	COG1846	Transcriptional regulator
H0N28_RS03155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0N28_RS03215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H0N28_RS03220	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H0N28_RS03225	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H0N28_RS03235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H0N28_RS03285	COG1214	PFAM Peptidase M22, glycoprotease
H0N28_RS03310	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H0N28_RS03315	COG0561	phosphatase activity
H0N28_RS03325	COG2132	Multicopper oxidase
H0N28_RS03345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H0N28_RS03350	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H0N28_RS03355	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H0N28_RS03385	COG1063	alcohol dehydrogenase
H0N28_RS03390	COG0583	DNA-binding transcription factor activity
H0N28_RS03395	COG1960	acyl-CoA dehydrogenase activity
H0N28_RS03400	COG2814	Major facilitator Superfamily
H0N28_RS03405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H0N28_RS03415	COG1053	succinate dehydrogenase
H0N28_RS03420	COG0583	DNA-binding transcription factor activity
H0N28_RS03435	COG0583	DNA-binding transcription factor activity
H0N28_RS03465	COG0583	DNA-binding transcription factor activity
H0N28_RS03480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0N28_RS03525	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0N28_RS03540	COG0745	RESPONSE REGULATOR receiver
H0N28_RS03580	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H0N28_RS03610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H0N28_RS03615	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0N28_RS03640	COG0583	DNA-binding transcription factor activity
H0N28_RS03660	COG0668	transmembrane transport
H0N28_RS03670	COG2081	HI0933 family
H0N28_RS03675	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H0N28_RS03715	COG0489	protein tyrosine kinase activity
H0N28_RS03765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H0N28_RS03775	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H0N28_RS03790	COG0730	response to heat
H0N28_RS03800	COG1196	nuclear chromosome segregation
H0N28_RS03820	COG2223	nitrite transmembrane transporter activity
H0N28_RS03825	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H0N28_RS03830	COG1877	trehalose-phosphatase activity
H0N28_RS03835	COG2226	methyltransferase
H0N28_RS03835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0N28_RS03835	COG0596	Alpha beta hydrolase
H0N28_RS03850	COG4106	trans-aconitate 2-methyltransferase activity
H0N28_RS03865	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H0N28_RS03870	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H0N28_RS03875	COG0009	L-threonylcarbamoyladenylate synthase
H0N28_RS03880	COG3101	peptidyl-lysine hydroxylation
H0N28_RS03885	COG1399	metal-binding, possibly nucleic acid-binding protein
H0N28_RS03910	COG1652	LysM domain
H0N28_RS03915	COG0351	phosphomethylpyrimidine kinase
H0N28_RS03915	COG0352	thiamine-phosphate diphosphorylase activity
H0N28_RS03915	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H0N28_RS03925	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0N28_RS03955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0N28_RS03985	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H0N28_RS04000	COG0358	DNA primase activity
H0N28_RS04010	COG0564	pseudouridine synthase activity
H0N28_RS04035	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0N28_RS04055	COG0583	DNA-binding transcription factor activity
H0N28_RS04060	COG0473	3-isopropylmalate dehydrogenase activity
H0N28_RS04070	COG0657	acetylesterase activity
H0N28_RS04080	COG1012	belongs to the aldehyde dehydrogenase family
H0N28_RS04100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0N28_RS04100	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H0N28_RS04115	COG1981	membrane
H0N28_RS04160	COG0456	acetyltransferase
H0N28_RS04170	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H0N28_RS04175	COG0492	ferredoxin-NADP+ reductase activity
H0N28_RS04180	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H0N28_RS04180	COG1674	ftsk spoiiie
H0N28_RS04185	COG1280	lysine exporter protein (LysE YggA)
H0N28_RS04200	COG2894	cell division
H0N28_RS04215	COG0204	Acyl-transferase
H0N28_RS04220	COG2885	chlorophyll binding
H0N28_RS04225	COG0210	DNA helicase
H0N28_RS04235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0N28_RS04250	COG0121	glutamine amidotransferase
H0N28_RS04270	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0N28_RS04275	COG0735	belongs to the Fur family
H0N28_RS04300	COG0420	3'-5' exonuclease activity
H0N28_RS04320	COG1090	epimerase
H0N28_RS04335	COG2050	protein possibly involved in aromatic compounds catabolism
H0N28_RS04345	COG2814	Major facilitator Superfamily
H0N28_RS04350	COG0405	Gamma-glutamyltransferase
H0N28_RS04390	COG0477	Major facilitator Superfamily
H0N28_RS04395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0N28_RS04425	COG2040	homocysteine
H0N28_RS04450	COG1309	transcriptional regulator
H0N28_RS04455	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0N28_RS04460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0N28_RS04470	COG1607	acyl-coa hydrolase
H0N28_RS04480	COG0523	cobalamin synthesis protein
H0N28_RS04490	COG4681	YaeQ
H0N28_RS04500	COG0726	polysaccharide deacetylase
H0N28_RS04500	COG1649	PFAM Uncharacterised BCR, COG1649
H0N28_RS04505	COG1215	transferase activity, transferring glycosyl groups
H0N28_RS04515	COG1024	Enoyl-CoA hydratase
H0N28_RS04530	COG1414	Transcriptional regulator
H0N28_RS04550	COG1028	Short-chain dehydrogenase reductase Sdr
H0N28_RS04560	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0N28_RS04565	COG2271	Major facilitator Superfamily
H0N28_RS04575	COG2267	carboxylic ester hydrolase activity
H0N28_RS04580	COG1028	Short-chain dehydrogenase reductase Sdr
H0N28_RS04595	COG0028	Belongs to the TPP enzyme family
H0N28_RS04605	COG0477	Major facilitator Superfamily
H0N28_RS04610	COG0242	peptide deformylase activity
H0N28_RS04615	COG2066	Belongs to the glutaminase family
H0N28_RS04620	COG2207	Transcriptional regulator
H0N28_RS04625	COG2223	nitrite transmembrane transporter activity
H0N28_RS04645	COG0583	DNA-binding transcription factor activity
H0N28_RS04650	COG1028	Short-chain dehydrogenase reductase Sdr
H0N28_RS04655	COG2271	Major facilitator Superfamily
H0N28_RS04660	COG3959	Transketolase, thiamine diphosphate binding domain
H0N28_RS04665	COG3958	Transketolase
H0N28_RS04675	COG0306	phosphate transporter
H0N28_RS04695	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H0N28_RS04740	COG4181	ATPase activity
H0N28_RS04745	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H0N28_RS04775	COG0583	DNA-binding transcription factor activity
H0N28_RS04785	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0N28_RS04790	COG1773	rubredoxin
H0N28_RS04840	COG2851	Citrate transporter
H0N28_RS04845	COG1253	flavin adenine dinucleotide binding
H0N28_RS04890	COG0804	urea catabolic process
H0N28_RS04900	COG0830	nickel cation binding
H0N28_RS04915	COG0742	ribosomal rna small subunit methyltransferase
H0N28_RS04920	COG0768	penicillin binding
H0N28_RS04945	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H0N28_RS04950	COG2878	Part of a membrane complex involved in electron transport
H0N28_RS04955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0N28_RS04965	COG3384	dioxygenase
H0N28_RS04990	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H0N28_RS05030	COG0006	proline dipeptidase activity
H0N28_RS05035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0N28_RS05040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0N28_RS05060	COG1279	arginine transmembrane transporter activity
H0N28_RS05065	COG0583	DNA-binding transcription factor activity
H0N28_RS05105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H0N28_RS05110	COG1388	LysM domain
H0N28_RS05110	COG1388	LysM domain
H0N28_RS05110	COG0741	lytic transglycosylase activity
H0N28_RS05110	COG0741	lytic transglycosylase activity
H0N28_RS05120	COG4174	ABC transporter (Permease)
H0N28_RS05125	COG4239	(ABC) transporter, permease
H0N28_RS05130	COG4172	Belongs to the ABC transporter superfamily
H0N28_RS05150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H0N28_RS05160	COG5001	Diguanylate cyclase
H0N28_RS05160	COG3706	GGDEF domain
H0N28_RS05160	COG4251	negative regulation of phosphorylation
H0N28_RS05160	COG2203	Gaf domain
H0N28_RS05175	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0N28_RS05175	COG1902	pentaerythritol trinitrate reductase activity
H0N28_RS05210	COG0251	oxidation-reduction process
H0N28_RS05220	COG0583	DNA-binding transcription factor activity
H0N28_RS05265	COG1113	amino acid transport
H0N28_RS05275	COG0531	amino acid
H0N28_RS05295	COG1012	belongs to the aldehyde dehydrogenase family
H0N28_RS05315	COG1113	amino acid transport
H0N28_RS05345	COG0697	spore germination
H0N28_RS05350	COG2721	sulfolactate sulfo-lyase activity
H0N28_RS05355	COG2271	Major facilitator Superfamily
H0N28_RS05360	COG4948	Mandelate Racemase Muconate Lactonizing
H0N28_RS05370	COG1012	belongs to the aldehyde dehydrogenase family
H0N28_RS05375	COG2186	Transcriptional regulator
H0N28_RS05400	COG1960	acyl-CoA dehydrogenase activity
H0N28_RS05410	COG1012	belongs to the aldehyde dehydrogenase family
H0N28_RS05415	COG1024	Enoyl-CoA hydratase
H0N28_RS05420	COG2814	Major facilitator Superfamily
H0N28_RS05435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0N28_RS05480	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H0N28_RS05485	COG2072	flavoprotein involved in K transport
H0N28_RS05490	COG0300	oxidoreductase activity
H0N28_RS05500	COG1309	transcriptional regulator
H0N28_RS05505	COG1741	Belongs to the pirin family
H0N28_RS05520	COG2072	flavoprotein involved in K transport
H0N28_RS05530	COG2252	PERMEase
H0N28_RS05535	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H0N28_RS05540	COG3038	cytochrome b561
H0N28_RS05550	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H0N28_RS05560	COG0527	aspartate kinase activity
H0N28_RS05610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H0N28_RS05615	COG4197	protein conserved in bacteria, prophage-related
H0N28_RS05695	COG5410	chromosome segregation
H0N28_RS05700	COG3567	Phage-associated protein, HI1409 family
H0N28_RS05720	COG3566	protein conserved in bacteria
H0N28_RS05855	COG0582	viral genome integration into host DNA
H0N28_RS05875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H0N28_RS05890	COG0667	Aldo Keto reductase
H0N28_RS05905	COG1765	OsmC-like protein
H0N28_RS05920	COG0542	response to heat
H0N28_RS05955	COG2885	chlorophyll binding
H0N28_RS05965	COG0625	glutathione transferase activity
H0N28_RS05970	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H0N28_RS05990	COG3634	alkyl hydroperoxide reductase activity
H0N28_RS06000	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H0N28_RS06010	COG0450	alkyl hydroperoxide reductase
H0N28_RS06015	COG1643	Atp-dependent helicase
H0N28_RS06030	COG2814	Major facilitator Superfamily
H0N28_RS06040	COG1028	Short-chain dehydrogenase reductase Sdr
H0N28_RS06045	COG0633	Ferredoxin
H0N28_RS06045	COG0543	2 iron, 2 sulfur cluster binding
H0N28_RS06050	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H0N28_RS06055	COG4638	Rieske (2fe-2S)
H0N28_RS06060	COG0583	DNA-binding transcription factor activity
H0N28_RS06110	COG1570	exodeoxyribonuclease VII activity
H0N28_RS06140	COG1280	lysine exporter protein (LysE YggA)
H0N28_RS06145	COG1278	Cold shock
H0N28_RS06180	COG2814	Major facilitator Superfamily
H0N28_RS06215	COG0517	IMP dehydrogenase activity
H0N28_RS06215	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H0N28_RS06220	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H0N28_RS06230	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H0N28_RS06235	COG1137	ATPase activity
H0N28_RS06240	COG1538	Outer membrane efflux protein
H0N28_RS06270	COG4122	O-methyltransferase activity
H0N28_RS06280	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H0N28_RS06295	COG1522	sequence-specific DNA binding
H0N28_RS06310	COG1560	Kdo2-lipid A biosynthetic process
H0N28_RS06315	COG0598	Magnesium transport protein CorA
H0N28_RS06330	COG2814	Major facilitator Superfamily
H0N28_RS06350	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0N28_RS06385	COG0583	DNA-binding transcription factor activity
H0N28_RS06390	COG1914	H( )-stimulated, divalent metal cation uptake system
H0N28_RS06410	COG4770	biotin carboxylase activity
H0N28_RS06415	COG0038	chloride channel
H0N28_RS06425	COG1309	transcriptional regulator
H0N28_RS06435	COG1063	alcohol dehydrogenase
H0N28_RS06450	COG0439	Biotin carboxylase
H0N28_RS06455	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0N28_RS06460	COG1733	regulation of RNA biosynthetic process
H0N28_RS06480	COG0864	Transcriptional regulator
H0N28_RS06490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0N28_RS06495	COG1116	anion transmembrane transporter activity
H0N28_RS06520	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H0N28_RS06625	COG0590	tRNA wobble adenosine to inosine editing
H0N28_RS06630	COG2807	transmembrane transport
H0N28_RS06645	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H0N28_RS06655	COG0789	Transcriptional regulator
H0N28_RS06665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0N28_RS06685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0N28_RS06710	COG1012	belongs to the aldehyde dehydrogenase family
H0N28_RS06715	COG0531	amino acid
H0N28_RS06720	COG1760	l-serine dehydratase
H0N28_RS06725	COG2030	dehydratase
H0N28_RS06725	COG1012	belongs to the aldehyde dehydrogenase family
H0N28_RS06730	COG3396	Phenylacetate-CoA oxygenase
H0N28_RS06735	COG3460	Phenylacetate-CoA oxygenase
H0N28_RS06740	COG3396	Phenylacetate-CoA oxygenase
H0N28_RS06745	COG2151	metal-sulfur cluster biosynthetic enzyme
H0N28_RS06750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0N28_RS06755	COG1024	Enoyl-CoA hydratase
H0N28_RS06760	COG1024	Enoyl-CoA hydratase
H0N28_RS06765	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0N28_RS06770	COG0183	Belongs to the thiolase family
H0N28_RS06775	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H0N28_RS06780	COG3327	negative regulation of DNA-templated transcription, initiation
H0N28_RS06790	COG2050	protein possibly involved in aromatic compounds catabolism
H0N28_RS06820	COG0753	catalase activity
H0N28_RS06825	COG3038	cytochrome b561
H0N28_RS06830	COG0583	DNA-binding transcription factor activity
H0N28_RS06840	COG1414	Transcriptional regulator
H0N28_RS06845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0N28_RS06860	COG1840	ABC-type Fe3 transport system, periplasmic component
H0N28_RS06865	COG3842	ATPase activity
H0N28_RS06880	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H0N28_RS06885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0N28_RS06905	COG0583	DNA-binding transcription factor activity
H0N28_RS06915	COG4770	biotin carboxylase activity
H0N28_RS06920	COG1024	Enoyl-CoA hydratase
H0N28_RS06925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H0N28_RS06930	COG1960	acyl-CoA dehydrogenase activity
H0N28_RS06935	COG1309	transcriptional regulator
H0N28_RS06940	COG0318	PFAM AMP-dependent synthetase and ligase
H0N28_RS06960	COG0583	DNA-binding transcription factor activity
H0N28_RS07010	COG1028	Short-chain dehydrogenase reductase Sdr
H0N28_RS07050	COG2205	protein histidine kinase activity
H0N28_RS07050	COG0784	Response regulator, receiver
H0N28_RS07070	COG0765	amino acid transport
H0N28_RS07075	COG0765	amino acid transport
H0N28_RS07085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0N28_RS07090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0N28_RS07115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H0N28_RS07120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0N28_RS07125	COG1045	serine acetyltransferase
H0N28_RS07140	COG0583	DNA-binding transcription factor activity
H0N28_RS07145	COG0625	glutathione transferase activity
H0N28_RS07150	COG0625	glutathione transferase activity
H0N28_RS07155	COG0583	DNA-binding transcription factor activity
H0N28_RS07165	COG1346	cytolysis
H0N28_RS07170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0N28_RS07185	COG2814	Major facilitator Superfamily
H0N28_RS07195	COG0583	DNA-binding transcription factor activity
H0N28_RS07205	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H0N28_RS07210	COG3052	prosthetic group binding
H0N28_RS07230	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H0N28_RS07250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0N28_RS07260	COG1294	oxidase, subunit
H0N28_RS07265	COG1271	oxidase subunit
H0N28_RS07285	COG0477	Major facilitator Superfamily
H0N28_RS07295	COG4521	taurine ABC transporter
H0N28_RS07300	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H0N28_RS07305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0N28_RS07310	COG2175	clavaminate synthase activity
H0N28_RS07320	COG1953	Uracil, thiamine, allantoin
H0N28_RS07330	COG0583	DNA-binding transcription factor activity
H0N28_RS07340	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H0N28_RS07355	COG0640	Transcriptional regulator
H0N28_RS07360	COG0798	PFAM Bile acid sodium symporter
H0N28_RS07365	COG0583	DNA-binding transcription factor activity
H0N28_RS07380	COG3634	alkyl hydroperoxide reductase activity
H0N28_RS07415	COG1301	dicarboxylic acid transport
H0N28_RS07420	COG0436	Aminotransferase
H0N28_RS07430	COG0386	Belongs to the glutathione peroxidase family
H0N28_RS07470	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H0N28_RS07495	COG0012	GTP binding
H0N28_RS07500	COG2011	ABC-type metal ion transport system permease component
H0N28_RS07505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H0N28_RS07515	COG1464	Belongs to the NlpA lipoprotein family
H0N28_RS07545	COG0765	amino acid transport
H0N28_RS07550	COG0765	amino acid transport
H0N28_RS07555	COG1126	abc transporter atp-binding protein
H0N28_RS07565	COG1522	sequence-specific DNA binding
H0N28_RS07580	COG1309	transcriptional regulator
H0N28_RS07600	COG0583	DNA-binding transcription factor activity
H0N28_RS07610	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H0N28_RS07620	COG0697	spore germination
H0N28_RS07645	COG3121	Chaperone
H0N28_RS07650	COG3539	Fimbrial protein
H0N28_RS07675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H0N28_RS07675	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H0N28_RS07720	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H0N28_RS07730	COG2353	YceI-like domain
H0N28_RS07740	COG3698	Phosphodiester glycosidase
H0N28_RS07755	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H0N28_RS07760	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H0N28_RS07760	COG0506	proline dehydrogenase activity
H0N28_RS07760	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H0N28_RS07770	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0N28_RS07775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H0N28_RS07795	COG1132	(ABC) transporter
H0N28_RS07800	COG3122	Protein conserved in bacteria
H0N28_RS07805	COG3619	membrane
H0N28_RS07815	COG0640	Transcriptional regulator
H0N28_RS07825	COG2850	peptidyl-arginine hydroxylation
H0N28_RS07830	COG0424	maF-like protein
H0N28_RS07850	COG0191	fructose-bisphosphate aldolase activity
H0N28_RS07855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0N28_RS07870	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H0N28_RS07880	COG1192	Involved in chromosome partitioning
H0N28_RS07885	COG1475	DNA binding
H0N28_RS07890	COG0811	peptide transport
H0N28_RS07900	COG1132	(ABC) transporter
H0N28_RS07905	COG1663	tetraacyldisaccharide 4'-kinase activity
H0N28_RS07925	COG0084	hydrolase, TatD family'
H0N28_RS07990	COG0776	regulation of translation
H0N28_RS08020	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H0N28_RS08085	COG0305	Participates in initiation and elongation during chromosome replication
H0N28_RS08175	COG4695	Portal protein
H0N28_RS08280	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H0N28_RS08330	COG0339	signal peptide processing
H0N28_RS08340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H0N28_RS08375	COG0702	epimerase
H0N28_RS08380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H0N28_RS08400	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H0N28_RS08430	COG0316	Belongs to the HesB IscA family
H0N28_RS08435	COG0822	iron-sulfur transferase activity
H0N28_RS08460	COG0776	regulation of translation
H0N28_RS08470	COG2207	Transcriptional regulator
H0N28_RS08475	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0N28_RS08480	COG1960	acyl-CoA dehydrogenase activity
H0N28_RS08485	COG1960	acyl-CoA dehydrogenase activity
H0N28_RS08500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H0N28_RS08515	COG2814	Major facilitator Superfamily
H0N28_RS08520	COG4264	IucA IucC family
H0N28_RS08525	COG4264	IucA IucC family
H0N28_RS08535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H0N28_RS08565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0N28_RS08580	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H0N28_RS08585	COG0406	alpha-ribazole phosphatase activity
H0N28_RS08600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H0N28_RS08605	COG0730	response to heat
H0N28_RS08625	COG4773	Receptor
H0N28_RS08630	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0N28_RS08645	COG1131	(ABC) transporter
H0N28_RS08650	COG0842	Transport permease protein
H0N28_RS08655	COG0842	Transport permease protein
H0N28_RS08710	COG2226	methyltransferase
H0N28_RS08735	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H0N28_RS08740	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H0N28_RS08770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0N28_RS08780	COG0133	tryptophan synthase activity
H0N28_RS08795	COG3706	GGDEF domain
H0N28_RS08810	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H0N28_RS08815	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H0N28_RS08820	COG0022	dehydrogenase e1 component
H0N28_RS08825	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0N28_RS08830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0N28_RS08840	COG1063	alcohol dehydrogenase
H0N28_RS08845	COG3781	membrane
H0N28_RS08855	COG3453	Protein conserved in bacteria
H0N28_RS08855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0N28_RS08880	COG3708	Transcriptional regulator
H0N28_RS08880	COG2207	Transcriptional regulator
H0N28_RS08885	COG1733	regulation of RNA biosynthetic process
H0N28_RS08890	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H0N28_RS08900	COG2188	Transcriptional regulator
H0N28_RS08915	COG4521	taurine ABC transporter
H0N28_RS08920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0N28_RS08940	COG0477	Major facilitator Superfamily
H0N28_RS08950	COG1027	Aspartate ammonia-lyase
H0N28_RS08965	COG0583	DNA-binding transcription factor activity
H0N28_RS08970	COG0583	DNA-binding transcription factor activity
H0N28_RS08975	COG0183	Belongs to the thiolase family
H0N28_RS08980	COG2031	fatty acid transporter
H0N28_RS08995	COG0583	DNA-binding transcription factor activity
H0N28_RS09015	COG1309	transcriptional regulator
H0N28_RS09025	COG2610	gluconate transmembrane transporter activity
H0N28_RS09030	COG1028	Short-chain dehydrogenase reductase Sdr
H0N28_RS09035	COG2207	Transcriptional regulator
H0N28_RS09050	COG1028	Short-chain dehydrogenase reductase Sdr
H0N28_RS09060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0N28_RS09095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0N28_RS09100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0N28_RS09105	COG0745	RESPONSE REGULATOR receiver
H0N28_RS09110	COG2205	protein histidine kinase activity
H0N28_RS09125	COG2207	Transcriptional regulator
H0N28_RS09175	COG2856	Zn peptidase
H0N28_RS09210	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H0N28_RS09305	COG1120	ATPase activity
H0N28_RS09310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H0N28_RS09320	COG1064	alcohol dehydrogenase
H0N28_RS09325	COG2207	Transcriptional regulator
H0N28_RS09330	COG2084	Dehydrogenase
H0N28_RS09340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0N28_RS09345	COG0583	DNA-binding transcription factor activity
H0N28_RS09355	COG0129	dihydroxy-acid dehydratase activity
H0N28_RS09360	COG1012	belongs to the aldehyde dehydrogenase family
H0N28_RS09375	COG1566	PFAM secretion protein HlyD family protein
H0N28_RS09390	COG0583	DNA-binding transcription factor activity
H0N28_RS09405	COG2188	Transcriptional regulator
H0N28_RS09480	COG0318	PFAM AMP-dependent synthetase and ligase
H0N28_RS09490	COG1960	acyl-CoA dehydrogenase activity
H0N28_RS09500	COG1028	Short-chain dehydrogenase reductase Sdr
H0N28_RS09505	COG1028	Short-chain dehydrogenase reductase Sdr
H0N28_RS09510	COG1028	Short-chain dehydrogenase reductase Sdr
H0N28_RS09515	COG0583	DNA-binding transcription factor activity
H0N28_RS09520	COG1309	transcriptional regulator
H0N28_RS09545	COG0789	Transcriptional regulator
H0N28_RS09555	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H0N28_RS09565	COG1902	pentaerythritol trinitrate reductase activity
H0N28_RS09565	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0N28_RS09580	COG1012	belongs to the aldehyde dehydrogenase family
H0N28_RS09600	COG2186	Transcriptional regulator
H0N28_RS09610	COG0583	DNA-binding transcription factor activity
H0N28_RS09615	COG4948	Mandelate Racemase Muconate Lactonizing
H0N28_RS09620	COG4829	muconolactone delta-isomerase
H0N28_RS09630	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H0N28_RS09635	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0N28_RS09640	COG0183	Belongs to the thiolase family
H0N28_RS09645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0N28_RS09655	COG1012	belongs to the aldehyde dehydrogenase family
H0N28_RS09675	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0N28_RS09685	COG1028	Short-chain dehydrogenase reductase Sdr
H0N28_RS09695	COG4638	Rieske (2fe-2S)
H0N28_RS09715	COG0154	amidase activity
H0N28_RS09725	COG2814	Major facilitator Superfamily
H0N28_RS09750	COG1960	acyl-CoA dehydrogenase activity
H0N28_RS09755	COG0583	DNA-binding transcription factor activity
H0N28_RS09760	COG1414	Transcriptional regulator
H0N28_RS09775	COG2391	methyltransferase activity
H0N28_RS09785	COG4993	Dehydrogenase
H0N28_RS09790	COG3659	wide pore channel activity
H0N28_RS09795	COG3420	alginic acid biosynthetic process
H0N28_RS09800	COG0710	3-dehydroquinate dehydratase activity
H0N28_RS09805	COG3485	protocatechuate 3,4-dioxygenase
H0N28_RS09810	COG3485	protocatechuate 3,4-dioxygenase
H0N28_RS09815	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H0N28_RS09820	COG2271	Major facilitator Superfamily
H0N28_RS09825	COG0596	Alpha beta hydrolase
H0N28_RS09830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H0N28_RS09835	COG0183	Belongs to the thiolase family
H0N28_RS09840	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0N28_RS09845	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H0N28_RS09855	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H0N28_RS09860	COG2323	membrane
H0N28_RS09905	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0N28_RS09905	COG1902	pentaerythritol trinitrate reductase activity
H0N28_RS09930	COG0542	response to heat
H0N28_RS09935	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H0N28_RS09965	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H0N28_RS09970	COG0569	domain protein
H0N28_RS09975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H0N28_RS09990	COG4774	siderophore transport
H0N28_RS09995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0N28_RS10005	COG1585	Membrane protein implicated in regulation of membrane protease activity
H0N28_RS10020	COG1294	oxidase, subunit
H0N28_RS10025	COG4890	Cyd operon protein YbgT
H0N28_RS10040	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H0N28_RS10050	COG0552	protein localization to endoplasmic reticulum
H0N28_RS10075	COG0516	GMP reductase activity
H0N28_RS10075	COG0517	IMP dehydrogenase activity
H0N28_RS10080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0N28_RS10085	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H0N28_RS10095	COG0583	DNA-binding transcription factor activity
H0N28_RS10100	COG0024	Methionine aminopeptidase
H0N28_RS10130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H0N28_RS10130	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0N28_RS10135	COG1105	Belongs to the carbohydrate kinase PfkB family
H0N28_RS10140	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H0N28_RS10140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H0N28_RS10140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H0N28_RS10155	COG3300	MHYT domain
H0N28_RS10155	COG5001	Diguanylate cyclase
H0N28_RS10170	COG2135	peptidase activity
H0N28_RS10175	COG0659	secondary active sulfate transmembrane transporter activity
H0N28_RS10190	COG1113	amino acid transport
H0N28_RS10200	COG1522	sequence-specific DNA binding
H0N28_RS10225	COG1011	Hydrolase
H0N28_RS10230	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H0N28_RS10240	COG2137	regulation of response to DNA damage stimulus
H0N28_RS10255	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0N28_RS10275	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0N28_RS10290	COG0575	Belongs to the CDS family
H0N28_RS10295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H0N28_RS10320	COG3852	Histidine kinase
H0N28_RS10325	COG2204	response regulator
H0N28_RS10380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0N28_RS10385	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H0N28_RS10405	COG0697	spore germination
H0N28_RS10410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0N28_RS10420	COG0303	'Molybdopterin
H0N28_RS10425	COG0315	cyclic pyranopterin monophosphate synthase activity
H0N28_RS10425	COG0521	Mo-molybdopterin cofactor biosynthetic process
H0N28_RS10440	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H0N28_RS10445	COG0243	molybdopterin cofactor binding
H0N28_RS10455	COG0243	molybdopterin cofactor binding
H0N28_RS10460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0N28_RS10465	COG2146	nitrite reductase [NAD(P)H] activity
H0N28_RS10465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0N28_RS10475	COG0745	RESPONSE REGULATOR receiver
H0N28_RS10480	COG1116	anion transmembrane transporter activity
H0N28_RS10480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0N28_RS10500	COG0511	ligase activity, forming carbon-carbon bonds
H0N28_RS10515	COG2814	Major facilitator Superfamily
H0N28_RS10530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H0N28_RS10600	COG1598	PFAM Uncharacterised protein family UPF0150
H0N28_RS10705	COG5410	chromosome segregation
H0N28_RS10745	COG3617	BRO family, N-terminal domain
H0N28_RS10890	COG0069	glutamate synthase activity
H0N28_RS10910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H0N28_RS10920	COG1454	alcohol dehydrogenase
H0N28_RS10925	COG0824	Thioesterase
H0N28_RS10935	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H0N28_RS10950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H0N28_RS10955	COG2030	dehydratase
H0N28_RS10965	COG0183	Belongs to the thiolase family
H0N28_RS10975	COG0583	DNA-binding transcription factor activity
H0N28_RS10980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H0N28_RS10990	COG1522	sequence-specific DNA binding
H0N28_RS10995	COG3135	benzoate transporter
H0N28_RS11005	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H0N28_RS11025	COG0589	response to stress
H0N28_RS11030	COG0488	(ABC) transporter
H0N28_RS11050	COG4773	Receptor
H0N28_RS11080	COG0668	transmembrane transport
H0N28_RS11090	COG1309	transcriptional regulator
H0N28_RS11105	COG1605	Chorismate mutase
H0N28_RS11145	COG0308	aminopeptidase N
H0N28_RS11170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0N28_RS11175	COG1454	alcohol dehydrogenase
H0N28_RS11195	COG0531	amino acid
H0N28_RS11200	COG4303	Ethanolamine ammonia lyase large subunit
H0N28_RS11205	COG4302	ethanolamine ammonia-lyase activity
H0N28_RS11210	COG0519	Catalyzes the synthesis of GMP from XMP
H0N28_RS11210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0N28_RS11215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0N28_RS11240	COG0697	spore germination
H0N28_RS11245	COG1923	regulation of RNA biosynthetic process
H0N28_RS11255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H0N28_RS11260	COG0802	atpase or kinase
H0N28_RS11280	COG1187	pseudouridine synthase activity
H0N28_RS11295	COG0583	DNA-binding transcription factor activity
H0N28_RS11310	COG2814	Major facilitator Superfamily
H0N28_RS11315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0N28_RS11340	COG0729	surface antigen
H0N28_RS11360	COG0174	glutamine synthetase
H0N28_RS11365	COG0745	RESPONSE REGULATOR receiver
H0N28_RS11370	COG2205	protein histidine kinase activity
H0N28_RS11375	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H0N28_RS11380	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H0N28_RS11385	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H0N28_RS11395	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H0N28_RS11410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0N28_RS11415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0N28_RS11420	COG1960	acyl-CoA dehydrogenase activity
H0N28_RS11450	COG0583	DNA-binding transcription factor activity
H0N28_RS11465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0N28_RS11475	COG3658	cytochrome
H0N28_RS11480	COG1215	transferase activity, transferring glycosyl groups
H0N28_RS11485	COG0726	polysaccharide deacetylase
H0N28_RS11485	COG1649	PFAM Uncharacterised BCR, COG1649
H0N28_RS11510	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H0N28_RS11515	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H0N28_RS11525	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H0N28_RS11550	COG0305	Participates in initiation and elongation during chromosome replication
H0N28_RS11555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H0N28_RS11565	COG1305	Transglutaminase-like
H0N28_RS11575	COG2308	Evidence 4 Homologs of previously reported genes of
H0N28_RS11605	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H0N28_RS11610	COG0138	bifunctional purine biosynthesis protein purh
H0N28_RS11615	COG0151	Belongs to the GarS family
H0N28_RS11625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H0N28_RS11630	COG2011	ABC-type metal ion transport system permease component
H0N28_RS11635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0N28_RS11645	COG1301	dicarboxylic acid transport
H0N28_RS11675	COG1794	racemase activity, acting on amino acids and derivatives
H0N28_RS11690	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H0N28_RS11690	COG3008	intermembrane lipid transfer
H0N28_RS11695	COG2995	paraquat-inducible protein a
H0N28_RS11725	COG1051	belongs to the nudix hydrolase family
H0N28_RS11730	COG0477	Major facilitator Superfamily
H0N28_RS11780	COG2186	Transcriptional regulator
H0N28_RS11790	COG0786	glutamate:sodium symporter activity
H0N28_RS11795	COG3243	poly(R)-hydroxyalkanoic acid synthase
H0N28_RS11820	COG3111	PFAM Bacterial OB fold (BOF) protein
H0N28_RS11890	COG0515	serine threonine protein kinase
H0N28_RS11890	COG2815	serine threonine protein kinase
H0N28_RS11920	COG1610	YqeY-like protein
H0N28_RS11925	COG4783	chaperone-mediated protein folding
H0N28_RS11950	COG1286	toxin biosynthetic process
H0N28_RS11980	COG0778	Nitroreductase
H0N28_RS11990	COG0513	Belongs to the DEAD box helicase family
H0N28_RS12010	COG2363	Small membrane protein
H0N28_RS12040	COG4650	regulator
H0N28_RS12045	COG1234	tRNA 3'-trailer cleavage
H0N28_RS12050	COG1690	Belongs to the RtcB family
H0N28_RS12070	COG2195	Cleaves the N-terminal amino acid of tripeptides
H0N28_RS12080	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H0N28_RS12090	COG2819	hydrolase of the alpha beta superfamily
H0N28_RS12095	COG1960	acyl-CoA dehydrogenase activity
H0N28_RS12100	COG1301	dicarboxylic acid transport
H0N28_RS12105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0N28_RS12110	COG3139	Protein of unknown function (DUF1315)
H0N28_RS12115	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H0N28_RS12120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H0N28_RS12130	COG0494	nUDIX hydrolase
H0N28_RS12140	COG0642	Histidine kinase
H0N28_RS12165	COG1720	tRNA m6t6A37 methyltransferase activity
H0N28_RS12180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0N28_RS12185	COG0826	peptidase U32
H0N28_RS12190	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0N28_RS12200	COG4598	ABC transporter
H0N28_RS12205	COG4160	amino acid transport
H0N28_RS12210	COG4215	(ABC) transporter
H0N28_RS12225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0N28_RS12270	COG1131	(ABC) transporter
H0N28_RS12275	COG0842	Transport permease protein
H0N28_RS12290	COG0772	Belongs to the SEDS family
H0N28_RS12295	COG2951	lytic endotransglycosylase activity
H0N28_RS12320	COG2207	Transcriptional regulator
H0N28_RS12335	COG0052	Belongs to the universal ribosomal protein uS2 family
H0N28_RS12340	COG0024	Methionine aminopeptidase
H0N28_RS12350	COG2223	nitrite transmembrane transporter activity
H0N28_RS12360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0N28_RS12365	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H0N28_RS12370	COG1960	acyl-CoA dehydrogenase activity
H0N28_RS12385	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H0N28_RS12390	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H0N28_RS12395	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H0N28_RS12415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0N28_RS12420	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H0N28_RS12425	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H0N28_RS12460	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H0N28_RS12470	COG0174	glutamine synthetase
H0N28_RS12485	COG0512	Glutamine amidotransferase of anthranilate synthase
H0N28_RS12490	COG0308	aminopeptidase N
H0N28_RS12520	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H0N28_RS12530	COG0302	gtp cyclohydrolase
H0N28_RS12550	COG3739	integral membrane protein
H0N28_RS12575	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H0N28_RS12580	COG1132	(ABC) transporter
H0N28_RS12585	COG1132	(ABC) transporter
H0N28_RS12595	COG3433	isochorismatase activity
H0N28_RS12595	COG1535	isochorismatase
H0N28_RS12600	COG1021	2,3-dihydroxybenzoate-AMP ligase
H0N28_RS12605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0N28_RS12615	COG4774	siderophore transport
H0N28_RS12620	COG4607	ABC-type enterochelin transport system periplasmic component
H0N28_RS12625	COG4604	ABC transporter, ATP-binding protein
H0N28_RS12630	COG4605	iron ion homeostasis
H0N28_RS12635	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H0N28_RS12640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0N28_RS12655	COG2964	Protein conserved in bacteria
H0N28_RS12665	COG1741	Belongs to the pirin family
H0N28_RS12705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0N28_RS12715	COG0596	Alpha beta hydrolase
H0N28_RS12730	COG0583	DNA-binding transcription factor activity
H0N28_RS12735	COG1335	isochorismatase
H0N28_RS12775	COG2879	small protein
H0N28_RS12780	COG1966	Carbon starvation protein
H0N28_RS12800	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H0N28_RS12825	COG1067	ATP-dependent peptidase activity
H0N28_RS12830	COG0583	DNA-binding transcription factor activity
H0N28_RS12855	COG1686	Belongs to the peptidase S11 family
H0N28_RS12860	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H0N28_RS12895	COG0616	signal peptide processing
H0N28_RS12900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H0N28_RS12910	COG0573	inorganic phosphate transmembrane transporter activity
H0N28_RS12915	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H0N28_RS12920	COG1113	amino acid transport
H0N28_RS12925	COG3961	Belongs to the TPP enzyme family
H0N28_RS12930	COG1522	sequence-specific DNA binding
H0N28_RS12940	COG0076	glutamate decarboxylase activity
H0N28_RS12945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H0N28_RS12960	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0N28_RS12970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0N28_RS13005	COG0352	thiamine-phosphate diphosphorylase activity
H0N28_RS13030	COG0612	Peptidase, M16
H0N28_RS13040	COG1823	symporter activity
H0N28_RS13045	COG0583	DNA-binding transcription factor activity
H0N28_RS13050	COG0477	Major facilitator Superfamily
H0N28_RS13075	COG1187	pseudouridine synthase activity
H0N28_RS13090	COG1686	Belongs to the peptidase S11 family
H0N28_RS13095	COG1252	NADH dehydrogenase
H0N28_RS13105	COG0415	Belongs to the DNA photolyase family
H0N28_RS13120	COG1215	transferase activity, transferring glycosyl groups
H0N28_RS13150	COG2070	2-Nitropropane dioxygenase
H0N28_RS13205	COG0556	nucleotide-excision repair
H0N28_RS13225	COG0436	Aminotransferase
H0N28_RS13235	COG0443	Heat shock 70 kDa protein
H0N28_RS13265	COG4221	oxidoreductase activity
H0N28_RS13275	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H0N28_RS13280	COG1381	Involved in DNA repair and RecF pathway recombination
H0N28_RS13290	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H0N28_RS13305	COG0681	Belongs to the peptidase S26 family
H0N28_RS13315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H0N28_RS13325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0N28_RS13345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H0N28_RS13350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H0N28_RS13355	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H0N28_RS13365	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H0N28_RS13370	COG4208	sulfate ABC transporter
H0N28_RS13375	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H0N28_RS13380	COG0583	DNA-binding transcription factor activity
H0N28_RS13385	COG4625	pathogenesis
H0N28_RS13400	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H0N28_RS13415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H0N28_RS13425	COG1051	belongs to the nudix hydrolase family
H0N28_RS13425	COG1056	cytidyltransferase-related domain
H0N28_RS13430	COG1024	Enoyl-CoA hydratase
H0N28_RS13500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0N28_RS13510	COG0534	Mate efflux family protein
H0N28_RS13525	COG4774	siderophore transport
H0N28_RS13530	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H0N28_RS13550	COG0019	diaminopimelate decarboxylase activity
H0N28_RS13555	COG3486	L-lysine 6-monooxygenase (NADPH) activity
H0N28_RS13560	COG1021	2,3-dihydroxybenzoate-AMP ligase
H0N28_RS13565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0N28_RS13570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0N28_RS13570	COG2226	methyltransferase
H0N28_RS13570	COG3433	isochorismatase activity
H0N28_RS13575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0N28_RS13580	COG1028	Short-chain dehydrogenase reductase Sdr
H0N28_RS13585	COG1535	isochorismatase
H0N28_RS13585	COG3433	isochorismatase activity
H0N28_RS13590	COG1169	isochorismate synthase
H0N28_RS13615	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H0N28_RS13615	COG0047	phosphoribosylformylglycinamidine synthase activity
H0N28_RS13635	COG1473	amidohydrolase
H0N28_RS13640	COG0824	Thioesterase
H0N28_RS13660	COG0823	Involved in the tonB-independent uptake of proteins
H0N28_RS13680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0N28_RS13715	COG0628	permease
H0N28_RS13725	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H0N28_RS13730	COG0596	Alpha beta hydrolase
H0N28_RS13735	COG0616	signal peptide processing
H0N28_RS13735	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H0N28_RS13745	COG0658	competence protein
H0N28_RS13745	COG2333	competence protein COMEC
H0N28_RS13750	COG1136	(ABC) transporter
H0N28_RS13755	COG4591	ABC-type transport system involved in lipoprotein release permease component
H0N28_RS13790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0N28_RS13810	COG0463	Glycosyl transferase, family 2
H0N28_RS13840	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H0N28_RS13845	COG1280	lysine exporter protein (LysE YggA)
H0N28_RS13855	COG0019	diaminopimelate decarboxylase activity
H0N28_RS13865	COG1113	amino acid transport
H0N28_RS13880	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H0N28_RS13890	COG3339	Conserved Protein
H0N28_RS13895	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H0N28_RS13900	COG0243	molybdopterin cofactor binding
H0N28_RS13905	COG1929	Belongs to the glycerate kinase type-1 family
H0N28_RS13920	COG0778	Nitroreductase
H0N28_RS13975	COG3811	Belongs to the UPF0386 family
H0N28_RS13985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0N28_RS14000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0N28_RS14020	COG0741	lytic transglycosylase activity
H0N28_RS14040	COG0584	glycerophosphoryl diester phosphodiesterase
H0N28_RS14045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0N28_RS14065	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H0N28_RS14070	COG1597	lipid kinase activity
H0N28_RS14085	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H0N28_RS14090	COG0477	Major facilitator Superfamily
H0N28_RS14140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H0N28_RS14145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0N28_RS14170	COG0505	Belongs to the CarA family
H0N28_RS14185	COG1309	transcriptional regulator
H0N28_RS14190	COG0251	oxidation-reduction process
H0N28_RS14200	COG0589	response to stress
H0N28_RS14215	COG2843	Capsule synthesis protein
H0N28_RS14235	COG2321	neutral zinc metallopeptidase
H0N28_RS14240	COG2354	Protein conserved in bacteria
H0N28_RS14260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0N28_RS14285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H0N28_RS14290	COG1053	succinate dehydrogenase
H0N28_RS14295	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H0N28_RS14300	COG2009	succinate dehydrogenase
H0N28_RS14340	COG2921	Belongs to the UPF0250 family
H0N28_RS14345	COG0321	lipoyl(octanoyl) transferase activity
H0N28_RS14360	COG0531	amino acid
H0N28_RS14370	COG1733	regulation of RNA biosynthetic process
H0N28_RS14375	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H0N28_RS14380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H0N28_RS14380	COG1648	precorrin-2 dehydrogenase activity
H0N28_RS14395	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H0N28_RS14425	COG0671	phosphoesterase, PA-phosphatase related
H0N28_RS14430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0N28_RS14440	COG1538	Outer membrane efflux protein
H0N28_RS14445	COG0393	Putative heavy-metal-binding
H0N28_RS14450	COG0393	Putative heavy-metal-binding
H0N28_RS14460	COG1028	Short-chain dehydrogenase reductase Sdr
H0N28_RS14470	COG0525	valine-tRNA ligase activity
H0N28_RS14490	COG0583	DNA-binding transcription factor activity
H0N28_RS14495	COG0004	ammonium transporteR
H0N28_RS14505	COG0642	Histidine kinase
H0N28_RS14510	COG0745	RESPONSE REGULATOR receiver
H0N28_RS14515	COG2194	sulfuric ester hydrolase activity
H0N28_RS14535	COG1752	Esterase of the alpha-beta hydrolase superfamily
H0N28_RS14550	COG2315	Protein conserved in bacteria
H0N28_RS14555	COG0142	geranyltranstransferase activity
H0N28_RS14560	COG2828	Protein conserved in bacteria
H0N28_RS14565	COG1113	amino acid transport
H0N28_RS14585	COG2207	Transcriptional regulator
H0N28_RS14610	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0N28_RS14620	COG0560	Phosphoserine phosphatase
H0N28_RS14630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0N28_RS14640	COG1530	ribonuclease E activity
H0N28_RS14645	COG0424	maF-like protein
H0N28_RS14650	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H0N28_RS14655	COG1792	Involved in formation and maintenance of cell shape
H0N28_RS14660	COG1077	Cell shape determining protein MreB Mrl
H0N28_RS14665	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0N28_RS14675	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0N28_RS14700	COG3590	peptidase
H0N28_RS14705	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H0N28_RS14710	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H0N28_RS14715	COG1752	Esterase of the alpha-beta hydrolase superfamily
H0N28_RS14720	COG1115	amino acid carrier protein
H0N28_RS14740	COG2814	Major facilitator Superfamily
H0N28_RS14745	COG1289	transmembrane transporter activity
H0N28_RS14755	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H0N28_RS14795	COG1376	ErfK ybiS ycfS ynhG family protein
H0N28_RS14800	COG2832	Protein of unknown function (DUF454)
H0N28_RS14810	COG5510	response to toxic substance
H0N28_RS14830	COG0840	transmembrane signaling receptor activity
H0N28_RS14870	COG3422	double-strand break repair
H0N28_RS14875	COG2824	Alkylphosphonate utilization operon protein PhnA
H0N28_RS14880	COG3189	MarR family transcriptional regulator
H0N28_RS14890	COG0354	folic acid binding
H0N28_RS14895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0N28_RS14910	COG1902	pentaerythritol trinitrate reductase activity
H0N28_RS14915	COG4772	TonB-dependent receptor
H0N28_RS14920	COG2094	Belongs to the DNA glycosylase MPG family
H0N28_RS14945	COG1217	gtp-binding protein TYPA
H0N28_RS14950	COG2233	PERMEase
H0N28_RS14960	COG0833	amino acid
H0N28_RS14965	COG1690	Belongs to the RtcB family
H0N28_RS14985	COG0183	Belongs to the thiolase family
H0N28_RS15005	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0N28_RS15025	COG2207	Transcriptional regulator
H0N28_RS15030	COG0183	Belongs to the thiolase family
H0N28_RS15050	COG2153	protein acetylation
H0N28_RS15060	COG1272	protein, Hemolysin III
H0N28_RS15065	COG0477	Major facilitator Superfamily
H0N28_RS15080	COG0450	alkyl hydroperoxide reductase
H0N28_RS15100	COG0285	dihydrofolate synthase activity
H0N28_RS15145	COG4206	TonB-dependent receptor
H0N28_RS15150	COG2096	Adenosyltransferase
H0N28_RS15170	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H0N28_RS15175	COG0745	RESPONSE REGULATOR receiver
H0N28_RS15180	COG2205	protein histidine kinase activity
H0N28_RS15190	COG1960	acyl-CoA dehydrogenase activity
H0N28_RS15195	COG1960	acyl-CoA dehydrogenase activity
H0N28_RS15260	COG0438	transferase activity, transferring glycosyl groups
H0N28_RS15265	COG0463	Glycosyl transferase, family 2
H0N28_RS15270	COG0726	polysaccharide deacetylase
H0N28_RS15290	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H0N28_RS15295	COG2205	protein histidine kinase activity
H0N28_RS15310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0N28_RS15335	COG0582	viral genome integration into host DNA
H0N28_RS15365	COG1862	Preprotein translocase
H0N28_RS15375	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H0N28_RS15380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H0N28_RS15390	COG3781	membrane
H0N28_RS15395	COG0613	PHP domain protein
H0N28_RS15405	COG2350	Protein conserved in bacteria
H0N28_RS15430	COG0582	viral genome integration into host DNA
H0N28_RS15480	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0N28_RS15505	COG2132	Multicopper oxidase
H0N28_RS15520	COG2205	protein histidine kinase activity
H0N28_RS15600	COG3013	Belongs to the UPF0304 family
H0N28_RS15630	COG1607	acyl-coa hydrolase
H0N28_RS15690	COG2199	diguanylate cyclase activity
H0N28_RS15700	COG1408	metallophosphoesterase
H0N28_RS15705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0N28_RS15715	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H0N28_RS15735	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H0N28_RS15740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H0N28_RS15745	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H0N28_RS15755	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H0N28_RS15765	COG2969	positive regulation of protein catabolic process
H0N28_RS15785	COG1960	acyl-CoA dehydrogenase activity
H0N28_RS15790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H0N28_RS15805	COG1309	transcriptional regulator
H0N28_RS15810	COG1960	acyl-CoA dehydrogenase activity
H0N28_RS15855	COG1183	phosphatidylcholine synthase activity
H0N28_RS15860	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H0N28_RS15890	COG0741	lytic transglycosylase activity
H0N28_RS15890	COG0739	heme binding
H0N28_RS15890	COG1196	nuclear chromosome segregation
H0N28_RS15900	COG1702	phosphate starvation-inducible protein PhoH
H0N28_RS15935	COG1295	ribonuclease BN
H0N28_RS15940	COG0697	spore germination
H0N28_RS15945	COG2169	Transcriptional regulator
H0N28_RS15950	COG0179	Fumarylacetoacetate (FAA) hydrolase
H0N28_RS15995	COG0557	exoribonuclease II activity
H0N28_RS16000	COG0339	signal peptide processing
H0N28_RS16005	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H0N28_RS16035	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H0N28_RS16040	COG1960	acyl-CoA dehydrogenase activity
H0N28_RS16195	COG0626	cystathionine gamma-synthase activity
H0N28_RS16200	COG0433	COG0433 Predicted ATPase
H0N28_RS16210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0N28_RS16210	COG1017	nitric oxide dioxygenase activity
H0N28_RS16215	COG1959	2 iron, 2 sulfur cluster binding
H0N28_RS16230	COG1301	dicarboxylic acid transport
H0N28_RS16235	COG1946	Acyl-CoA thioesterase
H0N28_RS16255	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H0N28_RS16260	COG1040	competence protein
H0N28_RS16265	COG0494	nUDIX hydrolase
H0N28_RS16275	COG0598	Magnesium transport protein CorA
H0N28_RS16285	COG2854	intermembrane phospholipid transfer
H0N28_RS16295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H0N28_RS16300	COG1127	ABC transporter
H0N28_RS16310	COG0513	Belongs to the DEAD box helicase family
H0N28_RS16330	COG0408	coproporphyrinogen oxidase activity
H0N28_RS16345	COG1960	acyl-CoA dehydrogenase activity
H0N28_RS16355	COG1983	PspC domain protein
H0N28_RS16360	COG0517	IMP dehydrogenase activity
H0N28_RS16410	COG0583	DNA-binding transcription factor activity
H0N28_RS16450	COG1012	belongs to the aldehyde dehydrogenase family
H0N28_RS16460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0N28_RS16465	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0N28_RS16470	COG0833	amino acid
H0N28_RS16500	COG1192	Involved in chromosome partitioning
H0N28_RS16505	COG0628	permease
H0N28_RS16515	COG1289	transmembrane transporter activity
H0N28_RS16530	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0N28_RS16535	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H0N28_RS16545	COG0277	FAD linked oxidase domain protein
H0N28_RS16550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H0N28_RS16575	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H0N28_RS16580	COG5380	lipid catabolic process
H0N28_RS16600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H0N28_RS16650	COG0194	GDP metabolic process
H0N28_RS16665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0N28_RS16685	COG3307	-O-antigen
H0N28_RS16690	COG4969	Belongs to the N-Me-Phe pilin family
H0N28_RS16700	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H0N28_RS16705	COG1704	LemA family
H0N28_RS16715	COG0493	'glutamate synthase
H0N28_RS16720	COG0070	glutamate synthase
H0N28_RS16720	COG0069	glutamate synthase activity
H0N28_RS16720	COG0067	glutamate synthase
H0N28_RS16770	COG2226	methyltransferase
H0N28_RS16785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H0N28_RS16790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H0N28_RS16835	COG0833	amino acid
H0N28_RS16900	COG0488	(ABC) transporter
H0N28_RS16925	COG4221	oxidoreductase activity
H0N28_RS16930	COG0659	secondary active sulfate transmembrane transporter activity
H0N28_RS16955	COG0427	acetyl-CoA hydrolase
H0N28_RS16985	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H0N28_RS17015	COG2329	Antibiotic biosynthesis monooxygenase
H0N28_RS17030	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H0N28_RS17085	COG2207	Transcriptional regulator
H0N28_RS17090	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H0N28_RS17110	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0N28_RS17115	COG1733	regulation of RNA biosynthetic process
H0N28_RS17145	COG1733	regulation of RNA biosynthetic process
H0N28_RS17190	COG0583	DNA-binding transcription factor activity
H0N28_RS17195	COG2814	Major facilitator Superfamily
H0N28_RS17235	COG1335	isochorismatase
H0N28_RS17245	COG1012	belongs to the aldehyde dehydrogenase family
H0N28_RS17250	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H0N28_RS17260	COG1113	amino acid transport
H0N28_RS17270	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H0N28_RS17285	COG2814	Major facilitator Superfamily
H0N28_RS17295	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H0N28_RS17295	COG0352	thiamine-phosphate diphosphorylase activity
H0N28_RS17295	COG0351	phosphomethylpyrimidine kinase
H0N28_RS17315	COG1309	transcriptional regulator
H0N28_RS17320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H0N28_RS17335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0N28_RS17345	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0N28_RS17350	COG3162	membrane
H0N28_RS17355	COG0784	Response regulator, receiver
H0N28_RS17355	COG2198	Histidine kinase
H0N28_RS17355	COG2205	protein histidine kinase activity
H0N28_RS17380	COG1522	sequence-specific DNA binding
H0N28_RS17385	COG1335	isochorismatase
H0N28_RS17390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0N28_RS17400	COG0668	transmembrane transport
H0N28_RS17410	COG1519	Transferase
H0N28_RS17415	COG1902	pentaerythritol trinitrate reductase activity
H0N28_RS17435	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H0N28_RS17460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0N28_RS17460	COG0426	domain, Protein
H0N28_RS17465	COG4774	siderophore transport
H0N28_RS17470	COG2119	membrane
H0N28_RS17480	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0N28_RS17490	COG4942	peptidase
H0N28_RS17505	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H0N28_RS17515	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H0N28_RS17535	COG0189	ligase activity
H0N28_RS17560	COG0708	Exodeoxyribonuclease III
H0N28_RS17565	COG1393	Belongs to the ArsC family
H0N28_RS17580	COG3706	GGDEF domain
H0N28_RS17615	COG2351	hydroxyisourate hydrolase activity
H0N28_RS17620	COG2233	PERMEase
H0N28_RS17630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0N28_RS17640	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H0N28_RS17650	COG3150	esterase
H0N28_RS17730	COG4691	Plasmid stability protein
H0N28_RS17765	COG0798	PFAM Bile acid sodium symporter
H0N28_RS17850	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H0N28_RS17880	COG0659	secondary active sulfate transmembrane transporter activity
H0N28_RS17885	COG0589	response to stress
H0N28_RS17935	COG0606	chelatase, subunit chli
H0N28_RS17940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0N28_RS17950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0N28_RS17965	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H0N28_RS17980	COG0318	PFAM AMP-dependent synthetase and ligase
H0N28_RS17990	COG0477	Major facilitator Superfamily
H0N28_RS17995	COG2860	membrane
H0N28_RS18000	COG3012	SEC-C Motif Domain Protein
H0N28_RS18005	COG1253	flavin adenine dinucleotide binding
H0N28_RS18015	COG0477	Major facilitator Superfamily
H0N28_RS18025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H0N28_RS18060	COG0655	NAD(P)H dehydrogenase (quinone) activity
H0N28_RS18070	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H0N28_RS18140	COG0758	DNA mediated transformation
H0N28_RS18150	COG0697	spore germination
H0N28_RS18155	COG1309	transcriptional regulator
H0N28_RS18170	COG0386	Belongs to the glutathione peroxidase family
H0N28_RS18240	COG1121	(ABC) transporter
H0N28_RS18245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0N28_RS18250	COG1280	lysine exporter protein (LysE YggA)
H0N28_RS18255	COG2837	iron assimilation
H0N28_RS18260	COG0281	malic enzyme
H0N28_RS18305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0N28_RS18305	COG0519	Catalyzes the synthesis of GMP from XMP
H0N28_RS18310	COG4399	Belongs to the UPF0754 family
H0N28_RS18315	COG2259	Doxx family
H0N28_RS18320	COG0586	Pfam SNARE associated Golgi protein
H0N28_RS18335	COG1192	Involved in chromosome partitioning
H0N28_RS18345	COG0271	Belongs to the BolA IbaG family
H0N28_RS18385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0N28_RS18385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H0N28_RS18385	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H0N28_RS18385	COG3321	synthase
H0N28_RS18390	COG1960	acyl-CoA dehydrogenase activity
H0N28_RS18395	COG0318	PFAM AMP-dependent synthetase and ligase
H0N28_RS18400	COG2197	response regulator
H0N28_RS18410	COG3916	Acyl-homoserine-lactone synthase
H0N28_RS18415	COG0477	Major facilitator Superfamily
H0N28_RS18420	COG1024	Enoyl-CoA hydratase
H0N28_RS18425	COG1024	Enoyl-CoA hydratase
H0N28_RS18430	COG1960	acyl-CoA dehydrogenase activity
H0N28_RS18435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0N28_RS18455	COG1113	amino acid transport
H0N28_RS18460	COG1113	amino acid transport
H0N28_RS18465	COG0251	oxidation-reduction process
H0N28_RS18505	COG0564	pseudouridine synthase activity
H0N28_RS18585	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H0N28_RS18600	COG1802	Transcriptional regulator
H0N28_RS18610	COG1448	Aminotransferase
H0N28_RS18615	COG0277	FAD linked oxidase domain protein
H0N28_RS18625	COG2186	Transcriptional regulator
H0N28_RS18635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0N28_RS18640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0N28_RS18655	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H0N28_RS18660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0N28_RS18685	COG0438	transferase activity, transferring glycosyl groups
H0N28_RS18715	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H0N28_RS18745	COG0728	peptidoglycan biosynthetic process
H0N28_RS18750	COG3023	N-Acetylmuramoyl-L-alanine amidase
H0N28_RS18810	COG0546	phosphoglycolate phosphatase activity
H0N28_RS18815	COG1028	Short-chain dehydrogenase reductase Sdr
H0N28_RS18835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0N28_RS18840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0N28_RS18845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0N28_RS18850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0N28_RS18855	COG1116	anion transmembrane transporter activity
H0N28_RS18860	COG1309	transcriptional regulator
H0N28_RS18865	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H0N28_RS18875	COG0196	riboflavin kinase activity
H0N28_RS18880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H0N28_RS18890	COG1047	Peptidyl-prolyl cis-trans
H0N28_RS18930	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0N28_RS18935	COG0657	acetylesterase activity
H0N28_RS18985	COG2951	lytic endotransglycosylase activity
H0N28_RS18990	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H0N28_RS19005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0N28_RS19015	COG0671	phosphoesterase, PA-phosphatase related
H0N28_RS19020	COG0861	Integral membrane protein TerC family
H0N28_RS19030	COG0754	glutathionylspermidine amidase activity
H0N28_RS19040	COG0402	S-adenosylhomocysteine deaminase activity
H0N28_RS19055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0N28_RS19060	COG1230	cation diffusion facilitator family transporter
H0N28_RS19075	COG0706	membrane insertase activity
H0N28_RS19115	COG3077	Addiction module antitoxin, RelB DinJ family
H0N28_RS19130	COG1028	Short-chain dehydrogenase reductase Sdr