locus-tag	class	description
AYP_RS00010	COG0592	DNA-directed DNA polymerase activity
AYP_RS00020	COG0187	DNA topoisomerase II activity
AYP_RS00030	COG0586	Pfam SNARE associated Golgi protein
AYP_RS00035	COG0488	(ABC) transporter
AYP_RS00060	COG0596	Alpha beta hydrolase
AYP_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AYP_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AYP_RS00115	COG1047	Peptidyl-prolyl cis-trans
AYP_RS00125	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AYP_RS00130	COG0196	riboflavin kinase activity
AYP_RS00140	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AYP_RS00145	COG1309	transcriptional regulator
AYP_RS00150	COG1116	anion transmembrane transporter activity
AYP_RS00155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AYP_RS00160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYP_RS00165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AYP_RS00170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AYP_RS00190	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_RS00195	COG0546	phosphoglycolate phosphatase activity
AYP_RS00255	COG3023	N-Acetylmuramoyl-L-alanine amidase
AYP_RS00260	COG0728	peptidoglycan biosynthetic process
AYP_RS00285	COG1596	polysaccharide export
AYP_RS00290	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AYP_RS00295	COG1086	Polysaccharide biosynthesis protein
AYP_RS00300	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AYP_RS00305	COG1083	cytidylyl-transferase
AYP_RS00320	COG2089	acid synthase
AYP_RS00350	COG1216	Glycosyl transferase, family 2
AYP_RS00355	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AYP_RS00360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AYP_RS00375	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AYP_RS00380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AYP_RS00390	COG2186	Transcriptional regulator
AYP_RS00400	COG0277	FAD linked oxidase domain protein
AYP_RS00405	COG1448	Aminotransferase
AYP_RS00415	COG1802	Transcriptional regulator
AYP_RS00430	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AYP_RS00495	COG0564	pseudouridine synthase activity
AYP_RS00535	COG0251	oxidation-reduction process
AYP_RS00540	COG1113	amino acid transport
AYP_RS00545	COG1113	amino acid transport
AYP_RS00565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYP_RS00570	COG1960	acyl-CoA dehydrogenase activity
AYP_RS00575	COG1024	Enoyl-CoA hydratase
AYP_RS00580	COG1024	Enoyl-CoA hydratase
AYP_RS00585	COG0477	Major facilitator Superfamily
AYP_RS00590	COG3916	Acyl-homoserine-lactone synthase
AYP_RS00600	COG2197	response regulator
AYP_RS00610	COG1960	acyl-CoA dehydrogenase activity
AYP_RS00615	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
AYP_RS00615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AYP_RS00615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AYP_RS00615	COG3321	synthase
AYP_RS00625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYP_RS00640	COG2267	carboxylic ester hydrolase activity
AYP_RS00660	COG0271	Belongs to the BolA IbaG family
AYP_RS00670	COG1192	Involved in chromosome partitioning
AYP_RS00685	COG0586	Pfam SNARE associated Golgi protein
AYP_RS00690	COG2259	Doxx family
AYP_RS00695	COG4399	Belongs to the UPF0754 family
AYP_RS00700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AYP_RS00700	COG0519	Catalyzes the synthesis of GMP from XMP
AYP_RS00745	COG0281	malic enzyme
AYP_RS00755	COG2837	iron assimilation
AYP_RS00760	COG1280	lysine exporter protein (LysE YggA)
AYP_RS00765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AYP_RS00770	COG1121	(ABC) transporter
AYP_RS00835	COG0386	Belongs to the glutathione peroxidase family
AYP_RS00850	COG1309	transcriptional regulator
AYP_RS00855	COG0697	spore germination
AYP_RS00865	COG0758	DNA mediated transformation
AYP_RS00900	COG1309	transcriptional regulator
AYP_RS00935	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AYP_RS00945	COG0655	NAD(P)H dehydrogenase (quinone) activity
AYP_RS00980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AYP_RS01000	COG1253	flavin adenine dinucleotide binding
AYP_RS01010	COG2860	membrane
AYP_RS01015	COG0477	Major facilitator Superfamily
AYP_RS01025	COG0318	PFAM AMP-dependent synthetase and ligase
AYP_RS01040	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AYP_RS01055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYP_RS01065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYP_RS01070	COG0606	chelatase, subunit chli
AYP_RS01110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AYP_RS01155	COG0589	response to stress
AYP_RS01160	COG0659	secondary active sulfate transmembrane transporter activity
AYP_RS01215	COG0606	chelatase, subunit chli
AYP_RS01225	COG0347	Belongs to the P(II) protein family
AYP_RS01230	COG0004	ammonium transporteR
AYP_RS01240	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AYP_RS01240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AYP_RS01280	COG0795	lipopolysaccharide-transporting ATPase activity
AYP_RS01285	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AYP_RS01290	COG0793	Belongs to the peptidase S41A family
AYP_RS01305	COG2197	response regulator
AYP_RS01315	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AYP_RS01325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AYP_RS01330	COG4974	Belongs to the 'phage' integrase family
AYP_RS01355	COG0772	Belongs to the SEDS family
AYP_RS01360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AYP_RS01365	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AYP_RS01370	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AYP_RS01400	COG1538	Outer membrane efflux protein
AYP_RS01420	COG3275	phosphorelay sensor kinase activity
AYP_RS01430	COG0181	hydroxymethylbilane synthase activity
AYP_RS01475	COG1716	ATPase activity
AYP_RS01480	COG0546	phosphoglycolate phosphatase activity
AYP_RS01585	COG0596	Alpha beta hydrolase
AYP_RS01590	COG2056	Na+-H+ antiporter family
AYP_RS01605	COG0326	Molecular chaperone. Has ATPase activity
AYP_RS01620	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AYP_RS01695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AYP_RS01700	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AYP_RS01700	COG2169	Transcriptional regulator
AYP_RS01730	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AYP_RS01740	COG0497	DNA recombination
AYP_RS01755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AYP_RS01765	COG0237	dephospho-CoA kinase activity
AYP_RS01815	COG0195	Participates in both transcription termination and antitermination
AYP_RS01830	COG1320	monovalent cation:proton antiporter activity
AYP_RS01835	COG2212	antiporter activity
AYP_RS01840	COG1863	multisubunit Na H antiporter MnhE subunit
AYP_RS01845	COG0651	ATP synthesis coupled electron transport
AYP_RS01850	COG1006	Multisubunit Na H antiporter MnhC subunit
AYP_RS01855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AYP_RS01855	COG2111	Na H antiporter
AYP_RS01870	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AYP_RS01875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYP_RS01890	COG2226	methyltransferase
AYP_RS01910	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AYP_RS01915	COG1074	ATP-dependent DNA helicase activity
AYP_RS01920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AYP_RS01925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYP_RS01940	COG0598	Magnesium transport protein CorA
AYP_RS01945	COG0789	Transcriptional regulator
AYP_RS01950	COG0484	heat shock protein binding
AYP_RS01960	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AYP_RS01965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AYP_RS01965	COG0475	glutathione-regulated potassium exporter activity
AYP_RS01970	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AYP_RS01990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYP_RS02000	COG4535	Mg2 and Co2 transporter CorC
AYP_RS02005	COG0425	Belongs to the sulfur carrier protein TusA family
AYP_RS02010	COG0644	oxidoreductase
AYP_RS02010	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AYP_RS02020	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AYP_RS02035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYP_RS02040	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AYP_RS02080	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AYP_RS02095	COG0534	Mate efflux family protein
AYP_RS02105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AYP_RS02110	COG4221	oxidoreductase activity
AYP_RS02115	COG0583	DNA-binding transcription factor activity
AYP_RS02130	COG0318	PFAM AMP-dependent synthetase and ligase
AYP_RS02135	COG1530	ribonuclease E activity
AYP_RS02150	COG0546	phosphoglycolate phosphatase activity
AYP_RS02155	COG2378	regulation of single-species biofilm formation
AYP_RS02160	COG0625	glutathione transferase activity
AYP_RS02170	COG0583	DNA-binding transcription factor activity
AYP_RS02235	COG0473	3-isopropylmalate dehydrogenase activity
AYP_RS02290	COG1301	dicarboxylic acid transport
AYP_RS02300	COG1560	Kdo2-lipid A biosynthetic process
AYP_RS02305	COG1280	lysine exporter protein (LysE YggA)
AYP_RS02310	COG0488	(ABC) transporter
AYP_RS02315	COG2900	Belongs to the SlyX family
AYP_RS02325	COG1733	regulation of RNA biosynthetic process
AYP_RS02350	COG0210	DNA helicase
AYP_RS02355	COG0724	RNA recognition motif
AYP_RS02375	COG4651	solute:proton antiporter activity
AYP_RS02375	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AYP_RS02400	COG0788	formyltetrahydrofolate deformylase activity
AYP_RS02500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AYP_RS02500	COG2813	Specifically methylates the guanine in position
AYP_RS02510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AYP_RS02520	COG4774	siderophore transport
AYP_RS02530	COG0740	serine-type endopeptidase activity
AYP_RS02550	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AYP_RS02550	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AYP_RS02555	COG0857	belongs to the CobB CobQ family
AYP_RS02555	COG0280	phosphate acetyltransferase
AYP_RS02560	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AYP_RS02575	COG0800	Aldolase
AYP_RS02585	COG3265	gluconokinase activity
AYP_RS02590	COG1012	belongs to the aldehyde dehydrogenase family
AYP_RS02600	COG2267	carboxylic ester hydrolase activity
AYP_RS02615	COG0793	Belongs to the peptidase S41A family
AYP_RS02650	COG1426	Protein conserved in bacteria
AYP_RS02695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AYP_RS02705	COG0318	PFAM AMP-dependent synthetase and ligase
AYP_RS02720	COG2986	histidine ammonia-lyase
AYP_RS02760	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_RS02765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AYP_RS02785	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AYP_RS02795	COG1162	GTPase activity
AYP_RS02800	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AYP_RS02815	COG1538	Outer membrane efflux protein
AYP_RS02820	COG0577	efflux transmembrane transporter activity
AYP_RS02820	COG1136	(ABC) transporter
AYP_RS02825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYP_RS02850	COG0028	Belongs to the TPP enzyme family
AYP_RS02855	COG0440	acetolactate synthase activity
AYP_RS02890	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AYP_RS02905	COG0084	hydrolase, TatD family'
AYP_RS02920	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AYP_RS02930	COG0583	DNA-binding transcription factor activity
AYP_RS02940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AYP_RS02945	COG2814	Major facilitator Superfamily
AYP_RS02955	COG0697	spore germination
AYP_RS02985	COG3622	Belongs to the hyi family
AYP_RS03010	COG1024	Enoyl-CoA hydratase
AYP_RS03015	COG0784	Response regulator, receiver
AYP_RS03015	COG2205	protein histidine kinase activity
AYP_RS03015	COG5002	protein histidine kinase activity
AYP_RS03035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AYP_RS03045	COG3956	TIGRFAM MazG family protein
AYP_RS03050	COG1555	photosystem II stabilization
AYP_RS03055	COG0617	tRNA 3'-terminal CCA addition
AYP_RS03060	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AYP_RS03080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AYP_RS03085	COG3028	Belongs to the UPF0307 family
AYP_RS03090	COG0318	PFAM AMP-dependent synthetase and ligase
AYP_RS03110	COG0625	glutathione transferase activity
AYP_RS03115	COG1238	metal cluster binding
AYP_RS03155	COG0072	phenylalanine-tRNA ligase activity
AYP_RS03185	COG0248	Ppx GppA phosphatase
AYP_RS03195	COG0037	tRNA processing
AYP_RS03235	COG1764	response to oxidative stress
AYP_RS03240	COG1846	Transcriptional regulator
AYP_RS03250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AYP_RS03310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AYP_RS03315	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AYP_RS03320	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AYP_RS03330	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AYP_RS03380	COG1214	PFAM Peptidase M22, glycoprotease
AYP_RS03405	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AYP_RS03410	COG0561	phosphatase activity
AYP_RS03420	COG2132	Multicopper oxidase
AYP_RS03425	COG3667	copper resistance
AYP_RS03440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AYP_RS03445	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AYP_RS03450	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AYP_RS03480	COG1063	alcohol dehydrogenase
AYP_RS03485	COG0583	DNA-binding transcription factor activity
AYP_RS03490	COG1960	acyl-CoA dehydrogenase activity
AYP_RS03495	COG2814	Major facilitator Superfamily
AYP_RS03500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AYP_RS03510	COG1053	succinate dehydrogenase
AYP_RS03515	COG0583	DNA-binding transcription factor activity
AYP_RS03535	COG0583	DNA-binding transcription factor activity
AYP_RS03565	COG0583	DNA-binding transcription factor activity
AYP_RS03580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYP_RS03610	COG0384	phenazine biosynthesis protein PhzF
AYP_RS03630	COG4993	Dehydrogenase
AYP_RS03700	COG2205	protein histidine kinase activity
AYP_RS03710	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AYP_RS03730	COG0745	RESPONSE REGULATOR receiver
AYP_RS03770	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AYP_RS03800	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AYP_RS03805	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AYP_RS03825	COG0583	DNA-binding transcription factor activity
AYP_RS03845	COG0668	transmembrane transport
AYP_RS03855	COG2081	HI0933 family
AYP_RS03860	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AYP_RS03890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYP_RS03890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYP_RS03900	COG0489	protein tyrosine kinase activity
AYP_RS03960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AYP_RS03970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AYP_RS03985	COG0730	response to heat
AYP_RS03995	COG1196	nuclear chromosome segregation
AYP_RS04015	COG2223	nitrite transmembrane transporter activity
AYP_RS04020	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AYP_RS04025	COG1877	trehalose-phosphatase activity
AYP_RS04030	COG2226	methyltransferase
AYP_RS04030	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AYP_RS04030	COG0596	Alpha beta hydrolase
AYP_RS04045	COG4106	trans-aconitate 2-methyltransferase activity
AYP_RS04060	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AYP_RS04065	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AYP_RS04070	COG0009	L-threonylcarbamoyladenylate synthase
AYP_RS04075	COG3101	peptidyl-lysine hydroxylation
AYP_RS04080	COG1399	metal-binding, possibly nucleic acid-binding protein
AYP_RS04105	COG1652	LysM domain
AYP_RS04110	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AYP_RS04110	COG0351	phosphomethylpyrimidine kinase
AYP_RS04110	COG0352	thiamine-phosphate diphosphorylase activity
AYP_RS04120	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AYP_RS04150	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AYP_RS04180	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AYP_RS04195	COG0358	DNA primase activity
AYP_RS04205	COG0564	pseudouridine synthase activity
AYP_RS04230	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AYP_RS04250	COG0583	DNA-binding transcription factor activity
AYP_RS04255	COG0473	3-isopropylmalate dehydrogenase activity
AYP_RS04265	COG0657	acetylesterase activity
AYP_RS04275	COG1012	belongs to the aldehyde dehydrogenase family
AYP_RS04295	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AYP_RS04295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AYP_RS04310	COG1981	membrane
AYP_RS04355	COG0456	acetyltransferase
AYP_RS04365	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AYP_RS04370	COG0492	ferredoxin-NADP+ reductase activity
AYP_RS04375	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AYP_RS04375	COG1674	ftsk spoiiie
AYP_RS04380	COG1280	lysine exporter protein (LysE YggA)
AYP_RS04400	COG2894	cell division
AYP_RS04415	COG0204	Acyl-transferase
AYP_RS04420	COG2885	chlorophyll binding
AYP_RS04425	COG0210	DNA helicase
AYP_RS04435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AYP_RS04450	COG0121	glutamine amidotransferase
AYP_RS04475	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AYP_RS04480	COG0735	belongs to the Fur family
AYP_RS04505	COG0420	3'-5' exonuclease activity
AYP_RS04525	COG1090	epimerase
AYP_RS04540	COG2050	protein possibly involved in aromatic compounds catabolism
AYP_RS04550	COG2814	Major facilitator Superfamily
AYP_RS04555	COG0405	Gamma-glutamyltransferase
AYP_RS04605	COG0477	Major facilitator Superfamily
AYP_RS04610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYP_RS04635	COG0531	amino acid
AYP_RS04640	COG2040	homocysteine
AYP_RS04665	COG1309	transcriptional regulator
AYP_RS04670	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYP_RS04675	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYP_RS04685	COG1607	acyl-coa hydrolase
AYP_RS04695	COG0523	cobalamin synthesis protein
AYP_RS04705	COG4681	YaeQ
AYP_RS04715	COG0726	polysaccharide deacetylase
AYP_RS04715	COG1649	PFAM Uncharacterised BCR, COG1649
AYP_RS04720	COG1215	transferase activity, transferring glycosyl groups
AYP_RS04730	COG1024	Enoyl-CoA hydratase
AYP_RS04745	COG1414	Transcriptional regulator
AYP_RS04765	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_RS04775	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYP_RS04780	COG2271	Major facilitator Superfamily
AYP_RS04790	COG2267	carboxylic ester hydrolase activity
AYP_RS04795	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_RS04810	COG0028	Belongs to the TPP enzyme family
AYP_RS04820	COG0477	Major facilitator Superfamily
AYP_RS04825	COG0242	peptide deformylase activity
AYP_RS04830	COG2066	Belongs to the glutaminase family
AYP_RS04835	COG2207	Transcriptional regulator
AYP_RS04840	COG2223	nitrite transmembrane transporter activity
AYP_RS04860	COG0583	DNA-binding transcription factor activity
AYP_RS04865	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_RS04870	COG2271	Major facilitator Superfamily
AYP_RS04875	COG3959	Transketolase, thiamine diphosphate binding domain
AYP_RS04880	COG3958	Transketolase
AYP_RS04890	COG0306	phosphate transporter
AYP_RS04910	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AYP_RS04955	COG4181	ATPase activity
AYP_RS04960	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AYP_RS04990	COG0583	DNA-binding transcription factor activity
AYP_RS05000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYP_RS05005	COG1773	rubredoxin
AYP_RS05055	COG2851	Citrate transporter
AYP_RS05065	COG1253	flavin adenine dinucleotide binding
AYP_RS05115	COG0830	nickel cation binding
AYP_RS05130	COG0742	ribosomal rna small subunit methyltransferase
AYP_RS05135	COG0768	penicillin binding
AYP_RS05160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AYP_RS05165	COG2878	Part of a membrane complex involved in electron transport
AYP_RS05170	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AYP_RS05180	COG3384	dioxygenase
AYP_RS05210	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AYP_RS05535	COG0739	heme binding
AYP_RS05580	COG2194	sulfuric ester hydrolase activity
AYP_RS05615	COG0006	proline dipeptidase activity
AYP_RS05620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYP_RS05625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYP_RS05645	COG1279	arginine transmembrane transporter activity
AYP_RS05650	COG0583	DNA-binding transcription factor activity
AYP_RS05690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AYP_RS05695	COG1388	LysM domain
AYP_RS05695	COG0741	lytic transglycosylase activity
AYP_RS05695	COG0741	lytic transglycosylase activity
AYP_RS05695	COG1388	LysM domain
AYP_RS05705	COG4174	ABC transporter (Permease)
AYP_RS05710	COG4239	(ABC) transporter, permease
AYP_RS05715	COG4172	Belongs to the ABC transporter superfamily
AYP_RS05735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AYP_RS05745	COG2203	Gaf domain
AYP_RS05745	COG3706	GGDEF domain
AYP_RS05745	COG4251	negative regulation of phosphorylation
AYP_RS05745	COG5001	Diguanylate cyclase
AYP_RS05755	COG1902	pentaerythritol trinitrate reductase activity
AYP_RS05755	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYP_RS05770	COG4269	membrane
AYP_RS05845	COG0789	Transcriptional regulator
AYP_RS05950	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AYP_RS06080	COG0300	oxidoreductase activity
AYP_RS06090	COG1309	transcriptional regulator
AYP_RS06095	COG1741	Belongs to the pirin family
AYP_RS06110	COG2072	flavoprotein involved in K transport
AYP_RS06120	COG2252	PERMEase
AYP_RS06125	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AYP_RS06130	COG3038	cytochrome b561
AYP_RS06140	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AYP_RS06150	COG0527	aspartate kinase activity
AYP_RS06160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AYP_RS06170	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AYP_RS06185	COG0667	Aldo Keto reductase
AYP_RS06200	COG1765	OsmC-like protein
AYP_RS06215	COG0542	response to heat
AYP_RS06250	COG2885	chlorophyll binding
AYP_RS06260	COG0625	glutathione transferase activity
AYP_RS06265	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AYP_RS06285	COG3634	alkyl hydroperoxide reductase activity
AYP_RS06295	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AYP_RS06305	COG0450	alkyl hydroperoxide reductase
AYP_RS06310	COG1643	Atp-dependent helicase
AYP_RS06325	COG2814	Major facilitator Superfamily
AYP_RS06330	COG3135	benzoate transporter
AYP_RS06335	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_RS06340	COG0543	2 iron, 2 sulfur cluster binding
AYP_RS06340	COG0633	Ferredoxin
AYP_RS06345	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AYP_RS06350	COG4638	Rieske (2fe-2S)
AYP_RS06355	COG0583	DNA-binding transcription factor activity
AYP_RS06410	COG1570	exodeoxyribonuclease VII activity
AYP_RS06445	COG1280	lysine exporter protein (LysE YggA)
AYP_RS06450	COG1278	Cold shock
AYP_RS06490	COG2814	Major facilitator Superfamily
AYP_RS06745	COG0517	IMP dehydrogenase activity
AYP_RS06745	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AYP_RS06750	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AYP_RS06760	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AYP_RS06765	COG1137	ATPase activity
AYP_RS06770	COG1538	Outer membrane efflux protein
AYP_RS06800	COG4122	O-methyltransferase activity
AYP_RS06810	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AYP_RS06825	COG1522	sequence-specific DNA binding
AYP_RS06830	COG5006	permease, DMT superfamily
AYP_RS06840	COG1560	Kdo2-lipid A biosynthetic process
AYP_RS06850	COG2814	Major facilitator Superfamily
AYP_RS06870	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYP_RS06925	COG0583	DNA-binding transcription factor activity
AYP_RS06930	COG1914	H( )-stimulated, divalent metal cation uptake system
AYP_RS06950	COG4770	biotin carboxylase activity
AYP_RS06955	COG0038	chloride channel
AYP_RS06980	COG1309	transcriptional regulator
AYP_RS06990	COG1063	alcohol dehydrogenase
AYP_RS07005	COG0439	Biotin carboxylase
AYP_RS07010	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYP_RS07030	COG0864	Transcriptional regulator
AYP_RS07040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYP_RS07045	COG1116	anion transmembrane transporter activity
AYP_RS07165	COG0590	tRNA wobble adenosine to inosine editing
AYP_RS07170	COG2807	transmembrane transport
AYP_RS07185	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AYP_RS07200	COG0789	Transcriptional regulator
AYP_RS07215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYP_RS07235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AYP_RS07245	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYP_RS07260	COG1012	belongs to the aldehyde dehydrogenase family
AYP_RS07265	COG0531	amino acid
AYP_RS07270	COG1760	l-serine dehydratase
AYP_RS07275	COG2030	dehydratase
AYP_RS07275	COG1012	belongs to the aldehyde dehydrogenase family
AYP_RS07280	COG3396	Phenylacetate-CoA oxygenase
AYP_RS07285	COG3460	Phenylacetate-CoA oxygenase
AYP_RS07290	COG3396	Phenylacetate-CoA oxygenase
AYP_RS07295	COG2151	metal-sulfur cluster biosynthetic enzyme
AYP_RS07300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYP_RS07305	COG1024	Enoyl-CoA hydratase
AYP_RS07310	COG1024	Enoyl-CoA hydratase
AYP_RS07315	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYP_RS07320	COG0183	Belongs to the thiolase family
AYP_RS07325	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AYP_RS07330	COG3327	negative regulation of DNA-templated transcription, initiation
AYP_RS07340	COG2050	protein possibly involved in aromatic compounds catabolism
AYP_RS07380	COG0753	catalase activity
AYP_RS07385	COG3038	cytochrome b561
AYP_RS07405	COG2267	carboxylic ester hydrolase activity
AYP_RS07410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYP_RS07415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYP_RS07420	COG1012	belongs to the aldehyde dehydrogenase family
AYP_RS07430	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AYP_RS07440	COG1012	belongs to the aldehyde dehydrogenase family
AYP_RS07445	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AYP_RS07450	COG0583	DNA-binding transcription factor activity
AYP_RS07460	COG1414	Transcriptional regulator
AYP_RS07465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYP_RS07475	COG1840	ABC-type Fe3 transport system, periplasmic component
AYP_RS07480	COG3842	ATPase activity
AYP_RS07505	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AYP_RS07510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AYP_RS07515	COG2814	Major facilitator Superfamily
AYP_RS07520	COG1960	acyl-CoA dehydrogenase activity
AYP_RS07535	COG1024	Enoyl-CoA hydratase
AYP_RS07545	COG2814	Major facilitator Superfamily
AYP_RS07555	COG0183	Belongs to the thiolase family
AYP_RS07560	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYP_RS07565	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_RS07570	COG1024	Enoyl-CoA hydratase
AYP_RS07575	COG1960	acyl-CoA dehydrogenase activity
AYP_RS07580	COG2814	Major facilitator Superfamily
AYP_RS07585	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AYP_RS07590	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AYP_RS07600	COG2814	Major facilitator Superfamily
AYP_RS07610	COG1960	acyl-CoA dehydrogenase activity
AYP_RS07625	COG0583	DNA-binding transcription factor activity
AYP_RS07635	COG4770	biotin carboxylase activity
AYP_RS07640	COG1024	Enoyl-CoA hydratase
AYP_RS07645	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AYP_RS07650	COG1960	acyl-CoA dehydrogenase activity
AYP_RS07655	COG1309	transcriptional regulator
AYP_RS07660	COG0318	PFAM AMP-dependent synthetase and ligase
AYP_RS07680	COG0583	DNA-binding transcription factor activity
AYP_RS07725	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_RS07745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AYP_RS07765	COG2205	protein histidine kinase activity
AYP_RS07765	COG0784	Response regulator, receiver
AYP_RS07785	COG0765	amino acid transport
AYP_RS07790	COG0765	amino acid transport
AYP_RS07795	COG1126	abc transporter atp-binding protein
AYP_RS07800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYP_RS07805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYP_RS07820	COG1280	lysine exporter protein (LysE YggA)
AYP_RS07830	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AYP_RS07835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AYP_RS07840	COG1045	serine acetyltransferase
AYP_RS07855	COG0583	DNA-binding transcription factor activity
AYP_RS07860	COG0625	glutathione transferase activity
AYP_RS07865	COG0625	glutathione transferase activity
AYP_RS07870	COG0583	DNA-binding transcription factor activity
AYP_RS07880	COG1346	cytolysis
AYP_RS07900	COG2814	Major facilitator Superfamily
AYP_RS07910	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AYP_RS07915	COG3052	prosthetic group binding
AYP_RS07935	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AYP_RS07955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYP_RS07965	COG1294	oxidase, subunit
AYP_RS07970	COG1271	oxidase subunit
AYP_RS07995	COG0477	Major facilitator Superfamily
AYP_RS08005	COG4521	taurine ABC transporter
AYP_RS08010	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AYP_RS08015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AYP_RS08020	COG2175	clavaminate synthase activity
AYP_RS08030	COG1953	Uracil, thiamine, allantoin
AYP_RS08040	COG0583	DNA-binding transcription factor activity
AYP_RS08050	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AYP_RS08065	COG0640	Transcriptional regulator
AYP_RS08070	COG0798	PFAM Bile acid sodium symporter
AYP_RS08075	COG0583	DNA-binding transcription factor activity
AYP_RS08090	COG3634	alkyl hydroperoxide reductase activity
AYP_RS08130	COG0436	Aminotransferase
AYP_RS08140	COG0386	Belongs to the glutathione peroxidase family
AYP_RS08180	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AYP_RS08205	COG0012	GTP binding
AYP_RS08210	COG2011	ABC-type metal ion transport system permease component
AYP_RS08215	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AYP_RS08225	COG1464	Belongs to the NlpA lipoprotein family
AYP_RS08255	COG0765	amino acid transport
AYP_RS08260	COG0765	amino acid transport
AYP_RS08265	COG1126	abc transporter atp-binding protein
AYP_RS08275	COG1522	sequence-specific DNA binding
AYP_RS08290	COG1309	transcriptional regulator
AYP_RS08310	COG0583	DNA-binding transcription factor activity
AYP_RS08320	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AYP_RS08330	COG0697	spore germination
AYP_RS08360	COG3121	Chaperone
AYP_RS08365	COG3539	Fimbrial protein
AYP_RS08390	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AYP_RS08390	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AYP_RS08435	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AYP_RS08445	COG2353	YceI-like domain
AYP_RS08455	COG3698	Phosphodiester glycosidase
AYP_RS08470	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AYP_RS08475	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AYP_RS08475	COG0506	proline dehydrogenase activity
AYP_RS08475	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AYP_RS08485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AYP_RS08490	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AYP_RS08510	COG1132	(ABC) transporter
AYP_RS08515	COG3122	Protein conserved in bacteria
AYP_RS08520	COG3619	membrane
AYP_RS08530	COG0640	Transcriptional regulator
AYP_RS08540	COG2850	peptidyl-arginine hydroxylation
AYP_RS08545	COG0424	maF-like protein
AYP_RS08565	COG0191	fructose-bisphosphate aldolase activity
AYP_RS08570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AYP_RS08585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AYP_RS08595	COG1192	Involved in chromosome partitioning
AYP_RS08600	COG1475	DNA binding
AYP_RS08605	COG0811	peptide transport
AYP_RS08615	COG1132	(ABC) transporter
AYP_RS08620	COG1663	tetraacyldisaccharide 4'-kinase activity
AYP_RS08640	COG0084	hydrolase, TatD family'
AYP_RS08705	COG0776	regulation of translation
AYP_RS08735	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AYP_RS08740	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AYP_RS08785	COG0339	signal peptide processing
AYP_RS08795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AYP_RS08835	COG0702	epimerase
AYP_RS08840	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AYP_RS08860	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AYP_RS08890	COG0316	Belongs to the HesB IscA family
AYP_RS08895	COG0822	iron-sulfur transferase activity
AYP_RS08920	COG0776	regulation of translation
AYP_RS08925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AYP_RS08930	COG2207	Transcriptional regulator
AYP_RS08935	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AYP_RS08940	COG1960	acyl-CoA dehydrogenase activity
AYP_RS08945	COG1960	acyl-CoA dehydrogenase activity
AYP_RS08960	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AYP_RS08980	COG4264	IucA IucC family
AYP_RS08985	COG4264	IucA IucC family
AYP_RS09045	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AYP_RS09065	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AYP_RS09070	COG0730	response to heat
AYP_RS09090	COG4773	Receptor
AYP_RS09095	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AYP_RS09110	COG1131	(ABC) transporter
AYP_RS09115	COG0842	Transport permease protein
AYP_RS09120	COG0842	Transport permease protein
AYP_RS09175	COG2226	methyltransferase
AYP_RS09200	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AYP_RS09240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYP_RS09250	COG0133	tryptophan synthase activity
AYP_RS09265	COG3706	GGDEF domain
AYP_RS09290	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AYP_RS09295	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AYP_RS09300	COG0022	dehydrogenase e1 component
AYP_RS09305	COG0508	dehydrogenase complex catalyzes the overall conversion of
AYP_RS09310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AYP_RS09320	COG1063	alcohol dehydrogenase
AYP_RS09325	COG3781	membrane
AYP_RS09335	COG3453	Protein conserved in bacteria
AYP_RS09335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYP_RS09345	COG0730	response to heat
AYP_RS09360	COG2207	Transcriptional regulator
AYP_RS09360	COG3708	Transcriptional regulator
AYP_RS09365	COG1733	regulation of RNA biosynthetic process
AYP_RS09370	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AYP_RS09380	COG2188	Transcriptional regulator
AYP_RS09395	COG4521	taurine ABC transporter
AYP_RS09400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AYP_RS09420	COG0477	Major facilitator Superfamily
AYP_RS09430	COG1027	Aspartate ammonia-lyase
AYP_RS09445	COG0583	DNA-binding transcription factor activity
AYP_RS09450	COG0583	DNA-binding transcription factor activity
AYP_RS09455	COG0183	Belongs to the thiolase family
AYP_RS09460	COG2031	fatty acid transporter
AYP_RS09465	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AYP_RS09475	COG0583	DNA-binding transcription factor activity
AYP_RS09485	COG2610	gluconate transmembrane transporter activity
AYP_RS09490	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_RS09500	COG2207	Transcriptional regulator
AYP_RS09515	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_RS09540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYP_RS09540	COG0543	2 iron, 2 sulfur cluster binding
AYP_RS09545	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AYP_RS09550	COG4638	Rieske (2fe-2S)
AYP_RS09560	COG0725	ABC transporter, periplasmic molybdate-binding protein
AYP_RS09565	COG4149	molybdate abc transporter
AYP_RS09570	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AYP_RS09575	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_RS09580	COG3433	isochorismatase activity
AYP_RS09580	COG1535	isochorismatase
AYP_RS09645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AYP_RS09660	COG0753	catalase activity
AYP_RS09670	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AYP_RS09700	COG3539	Fimbrial protein
AYP_RS09720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AYP_RS09740	COG2072	flavoprotein involved in K transport
AYP_RS09750	COG1538	Outer membrane efflux protein
AYP_RS09755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AYP_RS09760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYP_RS09765	COG0745	RESPONSE REGULATOR receiver
AYP_RS09770	COG2205	protein histidine kinase activity
AYP_RS09780	COG2207	Transcriptional regulator
AYP_RS09795	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_RS09855	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AYP_RS09975	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AYP_RS10000	COG1120	ATPase activity
AYP_RS10005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AYP_RS10015	COG1064	alcohol dehydrogenase
AYP_RS10030	COG2207	Transcriptional regulator
AYP_RS10035	COG2084	Dehydrogenase
AYP_RS10045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AYP_RS10050	COG0583	DNA-binding transcription factor activity
AYP_RS10060	COG0129	dihydroxy-acid dehydratase activity
AYP_RS10065	COG1012	belongs to the aldehyde dehydrogenase family
AYP_RS10080	COG1566	PFAM secretion protein HlyD family protein
AYP_RS10100	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AYP_RS10130	COG0583	DNA-binding transcription factor activity
AYP_RS10145	COG2188	Transcriptional regulator
AYP_RS10175	COG3210	domain, Protein
AYP_RS10180	COG2831	hemolysin activation secretion protein
AYP_RS10195	COG1473	amidohydrolase
AYP_RS10205	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AYP_RS10205	COG0475	glutathione-regulated potassium exporter activity
AYP_RS10215	COG0583	DNA-binding transcription factor activity
AYP_RS10220	COG1335	isochorismatase
AYP_RS10230	COG1309	transcriptional regulator
AYP_RS10260	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AYP_RS10270	COG1902	pentaerythritol trinitrate reductase activity
AYP_RS10270	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYP_RS10275	COG1846	Transcriptional regulator
AYP_RS10300	COG0753	catalase activity
AYP_RS10315	COG1012	belongs to the aldehyde dehydrogenase family
AYP_RS10330	COG3162	membrane
AYP_RS10340	COG3829	transcription factor binding
AYP_RS10345	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_RS10350	COG1960	acyl-CoA dehydrogenase activity
AYP_RS10370	COG1012	belongs to the aldehyde dehydrogenase family
AYP_RS10390	COG2186	Transcriptional regulator
AYP_RS10400	COG0583	DNA-binding transcription factor activity
AYP_RS10405	COG4948	Mandelate Racemase Muconate Lactonizing
AYP_RS10410	COG4829	muconolactone delta-isomerase
AYP_RS10420	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AYP_RS10425	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AYP_RS10430	COG0183	Belongs to the thiolase family
AYP_RS10435	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AYP_RS10445	COG1012	belongs to the aldehyde dehydrogenase family
AYP_RS10455	COG3733	amine oxidase
AYP_RS10465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYP_RS10475	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_RS10485	COG4638	Rieske (2fe-2S)
AYP_RS10505	COG0154	amidase activity
AYP_RS10515	COG2814	Major facilitator Superfamily
AYP_RS10540	COG1960	acyl-CoA dehydrogenase activity
AYP_RS10545	COG0583	DNA-binding transcription factor activity
AYP_RS10550	COG1414	Transcriptional regulator
AYP_RS10565	COG2391	methyltransferase activity
AYP_RS10575	COG4993	Dehydrogenase
AYP_RS10580	COG3659	wide pore channel activity
AYP_RS10585	COG3420	alginic acid biosynthetic process
AYP_RS10590	COG0710	3-dehydroquinate dehydratase activity
AYP_RS10595	COG3485	protocatechuate 3,4-dioxygenase
AYP_RS10600	COG3485	protocatechuate 3,4-dioxygenase
AYP_RS10605	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AYP_RS10610	COG2271	Major facilitator Superfamily
AYP_RS10615	COG0596	Alpha beta hydrolase
AYP_RS10620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AYP_RS10625	COG0183	Belongs to the thiolase family
AYP_RS10630	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AYP_RS10635	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AYP_RS10645	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AYP_RS10650	COG2323	membrane
AYP_RS10695	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYP_RS10695	COG1902	pentaerythritol trinitrate reductase activity
AYP_RS10720	COG0542	response to heat
AYP_RS10725	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AYP_RS10755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AYP_RS10760	COG0569	domain protein
AYP_RS10765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AYP_RS10780	COG4774	siderophore transport
AYP_RS10785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AYP_RS10795	COG1585	Membrane protein implicated in regulation of membrane protease activity
AYP_RS10815	COG1294	oxidase, subunit
AYP_RS10820	COG4890	Cyd operon protein YbgT
AYP_RS10835	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AYP_RS10845	COG0552	protein localization to endoplasmic reticulum
AYP_RS10870	COG0516	GMP reductase activity
AYP_RS10870	COG0517	IMP dehydrogenase activity
AYP_RS10875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AYP_RS10880	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AYP_RS10890	COG0583	DNA-binding transcription factor activity
AYP_RS10895	COG0024	Methionine aminopeptidase
AYP_RS10925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AYP_RS10925	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AYP_RS10930	COG1105	Belongs to the carbohydrate kinase PfkB family
AYP_RS10935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AYP_RS10935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AYP_RS10935	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AYP_RS10955	COG3300	MHYT domain
AYP_RS10955	COG5001	Diguanylate cyclase
AYP_RS10970	COG2135	peptidase activity
AYP_RS10975	COG0659	secondary active sulfate transmembrane transporter activity
AYP_RS10995	COG1113	amino acid transport
AYP_RS11005	COG1522	sequence-specific DNA binding
AYP_RS11030	COG1011	Hydrolase
AYP_RS11035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AYP_RS11045	COG2137	regulation of response to DNA damage stimulus
AYP_RS11060	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AYP_RS11095	COG0575	Belongs to the CDS family
AYP_RS11100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AYP_RS11120	COG3852	Histidine kinase
AYP_RS11125	COG2204	response regulator
AYP_RS11185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AYP_RS11190	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AYP_RS11210	COG0697	spore germination
AYP_RS11215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYP_RS11225	COG0303	'Molybdopterin
AYP_RS11230	COG0521	Mo-molybdopterin cofactor biosynthetic process
AYP_RS11230	COG0315	cyclic pyranopterin monophosphate synthase activity
AYP_RS11245	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AYP_RS11250	COG0243	molybdopterin cofactor binding
AYP_RS11260	COG0243	molybdopterin cofactor binding
AYP_RS11265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYP_RS11270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYP_RS11270	COG2146	nitrite reductase [NAD(P)H] activity
AYP_RS11280	COG0745	RESPONSE REGULATOR receiver
AYP_RS11285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AYP_RS11285	COG1116	anion transmembrane transporter activity
AYP_RS11305	COG0511	ligase activity, forming carbon-carbon bonds
AYP_RS11320	COG2814	Major facilitator Superfamily
AYP_RS11660	COG0069	glutamate synthase activity
AYP_RS11680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AYP_RS11690	COG1454	alcohol dehydrogenase
AYP_RS11695	COG0824	Thioesterase
AYP_RS11705	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AYP_RS11720	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYP_RS11725	COG2030	dehydratase
AYP_RS11735	COG0183	Belongs to the thiolase family
AYP_RS11745	COG0583	DNA-binding transcription factor activity
AYP_RS11750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AYP_RS11760	COG1522	sequence-specific DNA binding
AYP_RS11765	COG3135	benzoate transporter
AYP_RS11775	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AYP_RS11795	COG0589	response to stress
AYP_RS11800	COG0488	(ABC) transporter
AYP_RS11820	COG4773	Receptor
AYP_RS11850	COG0668	transmembrane transport
AYP_RS11860	COG1309	transcriptional regulator
AYP_RS11880	COG1605	Chorismate mutase
AYP_RS11890	COG4221	oxidoreductase activity
AYP_RS11900	COG0308	aminopeptidase N
AYP_RS11920	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AYP_RS11930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AYP_RS11935	COG1454	alcohol dehydrogenase
AYP_RS11955	COG0531	amino acid
AYP_RS11960	COG4303	Ethanolamine ammonia lyase large subunit
AYP_RS11965	COG4302	ethanolamine ammonia-lyase activity
AYP_RS11970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AYP_RS11970	COG0519	Catalyzes the synthesis of GMP from XMP
AYP_RS11975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AYP_RS11985	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AYP_RS12000	COG0697	spore germination
AYP_RS12005	COG1923	regulation of RNA biosynthetic process
AYP_RS12015	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AYP_RS12020	COG0802	atpase or kinase
AYP_RS12040	COG1187	pseudouridine synthase activity
AYP_RS12055	COG0583	DNA-binding transcription factor activity
AYP_RS12070	COG2814	Major facilitator Superfamily
AYP_RS12075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AYP_RS12105	COG0729	surface antigen
AYP_RS12125	COG0174	glutamine synthetase
AYP_RS12130	COG0745	RESPONSE REGULATOR receiver
AYP_RS12135	COG2205	protein histidine kinase activity
AYP_RS12145	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AYP_RS12150	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AYP_RS12175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYP_RS12180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYP_RS12185	COG1960	acyl-CoA dehydrogenase activity
AYP_RS12200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AYP_RS12205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AYP_RS12225	COG0583	DNA-binding transcription factor activity
AYP_RS12245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYP_RS12255	COG3658	cytochrome
AYP_RS12260	COG1215	transferase activity, transferring glycosyl groups
AYP_RS12265	COG0726	polysaccharide deacetylase
AYP_RS12265	COG1649	PFAM Uncharacterised BCR, COG1649
AYP_RS12290	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AYP_RS12295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AYP_RS12305	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AYP_RS12330	COG0305	Participates in initiation and elongation during chromosome replication
AYP_RS12335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AYP_RS12345	COG1305	Transglutaminase-like
AYP_RS12355	COG2308	Evidence 4 Homologs of previously reported genes of
AYP_RS12385	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AYP_RS12390	COG0138	bifunctional purine biosynthesis protein purh
AYP_RS12395	COG0151	Belongs to the GarS family
AYP_RS12400	COG1464	Belongs to the NlpA lipoprotein family
AYP_RS12405	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AYP_RS12410	COG2011	ABC-type metal ion transport system permease component
AYP_RS12415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYP_RS12425	COG1301	dicarboxylic acid transport
AYP_RS12455	COG1794	racemase activity, acting on amino acids and derivatives
AYP_RS12465	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AYP_RS12465	COG3008	intermembrane lipid transfer
AYP_RS12470	COG2995	paraquat-inducible protein a
AYP_RS12480	COG2985	domain, Protein
AYP_RS12510	COG0477	Major facilitator Superfamily
AYP_RS12560	COG2186	Transcriptional regulator
AYP_RS12570	COG0786	glutamate:sodium symporter activity
AYP_RS12575	COG3243	poly(R)-hydroxyalkanoic acid synthase
AYP_RS12605	COG3111	PFAM Bacterial OB fold (BOF) protein
AYP_RS12695	COG1610	YqeY-like protein
AYP_RS12700	COG4783	chaperone-mediated protein folding
AYP_RS12725	COG1286	toxin biosynthetic process
AYP_RS12755	COG0778	Nitroreductase
AYP_RS12765	COG0513	Belongs to the DEAD box helicase family
AYP_RS12785	COG2363	Small membrane protein
AYP_RS12815	COG1234	tRNA 3'-trailer cleavage
AYP_RS12820	COG2195	Cleaves the N-terminal amino acid of tripeptides
AYP_RS12830	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AYP_RS12840	COG2819	hydrolase of the alpha beta superfamily
AYP_RS12845	COG1960	acyl-CoA dehydrogenase activity
AYP_RS12850	COG1301	dicarboxylic acid transport
AYP_RS12860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AYP_RS12865	COG3139	Protein of unknown function (DUF1315)
AYP_RS12870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AYP_RS12875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AYP_RS12885	COG0494	nUDIX hydrolase
AYP_RS12895	COG0642	Histidine kinase
AYP_RS12910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AYP_RS12920	COG1720	tRNA m6t6A37 methyltransferase activity
AYP_RS12935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYP_RS12940	COG0826	peptidase U32
AYP_RS12945	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AYP_RS12955	COG4598	ABC transporter
AYP_RS12960	COG4160	amino acid transport
AYP_RS12965	COG4215	(ABC) transporter
AYP_RS12980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYP_RS13025	COG1131	(ABC) transporter
AYP_RS13030	COG0842	Transport permease protein
AYP_RS13045	COG0772	Belongs to the SEDS family
AYP_RS13050	COG2951	lytic endotransglycosylase activity
AYP_RS13075	COG2207	Transcriptional regulator
AYP_RS13090	COG0052	Belongs to the universal ribosomal protein uS2 family
AYP_RS13095	COG0024	Methionine aminopeptidase
AYP_RS13105	COG2223	nitrite transmembrane transporter activity
AYP_RS13115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AYP_RS13120	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AYP_RS13125	COG1960	acyl-CoA dehydrogenase activity
AYP_RS13140	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AYP_RS13145	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AYP_RS13150	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AYP_RS13170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AYP_RS13175	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AYP_RS13180	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AYP_RS13215	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AYP_RS13225	COG0174	glutamine synthetase
AYP_RS13240	COG0512	Glutamine amidotransferase of anthranilate synthase
AYP_RS13300	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AYP_RS13310	COG0302	gtp cyclohydrolase
AYP_RS13335	COG3739	integral membrane protein
AYP_RS13350	COG1169	isochorismate synthase
AYP_RS13360	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AYP_RS13365	COG1132	(ABC) transporter
AYP_RS13370	COG1132	(ABC) transporter
AYP_RS13385	COG3433	isochorismatase activity
AYP_RS13385	COG1535	isochorismatase
AYP_RS13390	COG1021	2,3-dihydroxybenzoate-AMP ligase
AYP_RS13395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYP_RS13405	COG4774	siderophore transport
AYP_RS13410	COG4607	ABC-type enterochelin transport system periplasmic component
AYP_RS13415	COG4604	ABC transporter, ATP-binding protein
AYP_RS13420	COG4605	iron ion homeostasis
AYP_RS13425	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AYP_RS13430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYP_RS13445	COG2964	Protein conserved in bacteria
AYP_RS13455	COG1741	Belongs to the pirin family
AYP_RS13475	COG1309	transcriptional regulator
AYP_RS13485	COG4948	Mandelate Racemase Muconate Lactonizing
AYP_RS13490	COG2814	Major facilitator Superfamily
AYP_RS13525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AYP_RS13525	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AYP_RS13530	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYP_RS13535	COG1012	belongs to the aldehyde dehydrogenase family
AYP_RS13545	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYP_RS13550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYP_RS13555	COG0583	DNA-binding transcription factor activity
AYP_RS13560	COG1113	amino acid transport
AYP_RS13580	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AYP_RS13580	COG2508	Transcriptional regulator
AYP_RS13615	COG2879	small protein
AYP_RS13620	COG1966	Carbon starvation protein
AYP_RS13665	COG1067	ATP-dependent peptidase activity
AYP_RS13670	COG0583	DNA-binding transcription factor activity
AYP_RS13695	COG1686	Belongs to the peptidase S11 family
AYP_RS13700	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AYP_RS13735	COG0616	signal peptide processing
AYP_RS13740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AYP_RS13750	COG0573	inorganic phosphate transmembrane transporter activity
AYP_RS13755	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AYP_RS13760	COG1113	amino acid transport
AYP_RS13765	COG3961	Belongs to the TPP enzyme family
AYP_RS13770	COG1522	sequence-specific DNA binding
AYP_RS13780	COG0076	glutamate decarboxylase activity
AYP_RS13785	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AYP_RS13795	COG1309	transcriptional regulator
AYP_RS13810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYP_RS13845	COG0352	thiamine-phosphate diphosphorylase activity
AYP_RS13870	COG0612	Peptidase, M16
AYP_RS13880	COG1823	symporter activity
AYP_RS13885	COG0583	DNA-binding transcription factor activity
AYP_RS13890	COG0477	Major facilitator Superfamily
AYP_RS13915	COG1187	pseudouridine synthase activity
AYP_RS13930	COG1686	Belongs to the peptidase S11 family
AYP_RS13935	COG1252	NADH dehydrogenase
AYP_RS13945	COG0415	Belongs to the DNA photolyase family
AYP_RS13960	COG1215	transferase activity, transferring glycosyl groups
AYP_RS13990	COG2070	2-Nitropropane dioxygenase
AYP_RS14180	COG5410	chromosome segregation
AYP_RS14375	COG0556	nucleotide-excision repair
AYP_RS14395	COG0436	Aminotransferase
AYP_RS14425	COG4221	oxidoreductase activity
AYP_RS14435	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AYP_RS14440	COG1381	Involved in DNA repair and RecF pathway recombination
AYP_RS14450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AYP_RS14465	COG0681	Belongs to the peptidase S26 family
AYP_RS14480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AYP_RS14500	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AYP_RS14505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AYP_RS14510	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AYP_RS14520	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AYP_RS14525	COG4208	sulfate ABC transporter
AYP_RS14530	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AYP_RS14535	COG0583	DNA-binding transcription factor activity
AYP_RS14540	COG4625	pathogenesis
AYP_RS14555	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AYP_RS14570	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AYP_RS14580	COG1056	cytidyltransferase-related domain
AYP_RS14580	COG1051	belongs to the nudix hydrolase family
AYP_RS14585	COG1024	Enoyl-CoA hydratase
AYP_RS14595	COG2814	Major facilitator Superfamily
AYP_RS14600	COG0047	phosphoribosylformylglycinamidine synthase activity
AYP_RS14600	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AYP_RS14620	COG1473	amidohydrolase
AYP_RS14625	COG0824	Thioesterase
AYP_RS14645	COG0823	Involved in the tonB-independent uptake of proteins
AYP_RS14665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AYP_RS14700	COG0628	permease
AYP_RS14710	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AYP_RS14715	COG0596	Alpha beta hydrolase
AYP_RS14720	COG0616	signal peptide processing
AYP_RS14720	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AYP_RS14730	COG2333	competence protein COMEC
AYP_RS14730	COG0658	competence protein
AYP_RS14735	COG1136	(ABC) transporter
AYP_RS14740	COG4591	ABC-type transport system involved in lipoprotein release permease component
AYP_RS14770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYP_RS14790	COG0463	Glycosyl transferase, family 2
AYP_RS14820	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AYP_RS14825	COG1280	lysine exporter protein (LysE YggA)
AYP_RS14835	COG0019	diaminopimelate decarboxylase activity
AYP_RS14845	COG1113	amino acid transport
AYP_RS14860	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AYP_RS14870	COG3339	Conserved Protein
AYP_RS14875	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AYP_RS14880	COG0243	molybdopterin cofactor binding
AYP_RS14885	COG1929	Belongs to the glycerate kinase type-1 family
AYP_RS14900	COG0778	Nitroreductase
AYP_RS14925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYP_RS14940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AYP_RS14965	COG0741	lytic transglycosylase activity
AYP_RS14985	COG0584	glycerophosphoryl diester phosphodiesterase
AYP_RS14990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYP_RS15015	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AYP_RS15020	COG1597	lipid kinase activity
AYP_RS15035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AYP_RS15040	COG0477	Major facilitator Superfamily
AYP_RS15090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AYP_RS15095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYP_RS15120	COG0505	Belongs to the CarA family
AYP_RS15140	COG0589	response to stress
AYP_RS15155	COG2843	Capsule synthesis protein
AYP_RS15195	COG2321	neutral zinc metallopeptidase
AYP_RS15200	COG2354	Protein conserved in bacteria
AYP_RS15220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AYP_RS15245	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AYP_RS15250	COG1053	succinate dehydrogenase
AYP_RS15255	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AYP_RS15260	COG2009	succinate dehydrogenase
AYP_RS15305	COG2921	Belongs to the UPF0250 family
AYP_RS15310	COG0321	lipoyl(octanoyl) transferase activity
AYP_RS15325	COG0531	amino acid
AYP_RS15335	COG1733	regulation of RNA biosynthetic process
AYP_RS15340	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AYP_RS15345	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AYP_RS15345	COG1648	precorrin-2 dehydrogenase activity
AYP_RS15360	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AYP_RS15390	COG0671	phosphoesterase, PA-phosphatase related
AYP_RS15395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYP_RS15405	COG1538	Outer membrane efflux protein
AYP_RS15410	COG0393	Putative heavy-metal-binding
AYP_RS15415	COG0393	Putative heavy-metal-binding
AYP_RS15425	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_RS15435	COG0525	valine-tRNA ligase activity
AYP_RS15455	COG0583	DNA-binding transcription factor activity
AYP_RS15465	COG0004	ammonium transporteR
AYP_RS15475	COG0642	Histidine kinase
AYP_RS15480	COG0745	RESPONSE REGULATOR receiver
AYP_RS15485	COG2194	sulfuric ester hydrolase activity
AYP_RS15505	COG1752	Esterase of the alpha-beta hydrolase superfamily
AYP_RS15520	COG2315	Protein conserved in bacteria
AYP_RS15525	COG0142	geranyltranstransferase activity
AYP_RS15530	COG2828	Protein conserved in bacteria
AYP_RS15535	COG1113	amino acid transport
AYP_RS15555	COG2207	Transcriptional regulator
AYP_RS15590	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYP_RS15600	COG0560	Phosphoserine phosphatase
AYP_RS15610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYP_RS15620	COG1530	ribonuclease E activity
AYP_RS15625	COG0424	maF-like protein
AYP_RS15630	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AYP_RS15635	COG1792	Involved in formation and maintenance of cell shape
AYP_RS15640	COG1077	Cell shape determining protein MreB Mrl
AYP_RS15645	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AYP_RS15655	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AYP_RS15685	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AYP_RS15690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AYP_RS15695	COG1752	Esterase of the alpha-beta hydrolase superfamily
AYP_RS15700	COG1115	amino acid carrier protein
AYP_RS15720	COG2814	Major facilitator Superfamily
AYP_RS15725	COG1289	transmembrane transporter activity
AYP_RS15735	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AYP_RS15775	COG1376	ErfK ybiS ycfS ynhG family protein
AYP_RS15780	COG2832	Protein of unknown function (DUF454)
AYP_RS15790	COG5510	response to toxic substance
AYP_RS15810	COG0840	transmembrane signaling receptor activity
AYP_RS15860	COG3422	double-strand break repair
AYP_RS15865	COG2824	Alkylphosphonate utilization operon protein PhnA
AYP_RS15870	COG3189	MarR family transcriptional regulator
AYP_RS15880	COG0354	folic acid binding
AYP_RS15885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AYP_RS15900	COG1902	pentaerythritol trinitrate reductase activity
AYP_RS15905	COG4772	TonB-dependent receptor
AYP_RS15910	COG2094	Belongs to the DNA glycosylase MPG family
AYP_RS15935	COG1217	gtp-binding protein TYPA
AYP_RS15940	COG2233	PERMEase
AYP_RS15950	COG0833	amino acid
AYP_RS15955	COG1690	Belongs to the RtcB family
AYP_RS15965	COG2885	chlorophyll binding
AYP_RS15965	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AYP_RS15975	COG0183	Belongs to the thiolase family
AYP_RS16000	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYP_RS16020	COG2207	Transcriptional regulator
AYP_RS16025	COG0183	Belongs to the thiolase family
AYP_RS16055	COG1272	protein, Hemolysin III
AYP_RS16060	COG0477	Major facilitator Superfamily
AYP_RS16075	COG0450	alkyl hydroperoxide reductase
AYP_RS16095	COG0285	dihydrofolate synthase activity
AYP_RS16145	COG2096	Adenosyltransferase
AYP_RS16165	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AYP_RS16170	COG0745	RESPONSE REGULATOR receiver
AYP_RS16175	COG2205	protein histidine kinase activity
AYP_RS16185	COG1960	acyl-CoA dehydrogenase activity
AYP_RS16190	COG1960	acyl-CoA dehydrogenase activity
AYP_RS16195	COG0583	DNA-binding transcription factor activity
AYP_RS16200	COG0625	glutathione transferase activity
AYP_RS16265	COG0438	transferase activity, transferring glycosyl groups
AYP_RS16270	COG0463	Glycosyl transferase, family 2
AYP_RS16275	COG0726	polysaccharide deacetylase
AYP_RS16295	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AYP_RS16300	COG2205	protein histidine kinase activity
AYP_RS16350	COG1862	Preprotein translocase
AYP_RS16360	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AYP_RS16365	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AYP_RS16375	COG3781	membrane
AYP_RS16380	COG0613	PHP domain protein
AYP_RS16390	COG2350	Protein conserved in bacteria
AYP_RS16420	COG1607	acyl-coa hydrolase
AYP_RS16480	COG2199	diguanylate cyclase activity
AYP_RS16490	COG1408	metallophosphoesterase
AYP_RS16495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AYP_RS16505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AYP_RS16615	COG0741	lytic transglycosylase activity
AYP_RS16615	COG0739	heme binding
AYP_RS16615	COG1196	nuclear chromosome segregation
AYP_RS16630	COG1598	PFAM Uncharacterised protein family UPF0150
AYP_RS16740	COG5410	chromosome segregation
AYP_RS16900	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AYP_RS16905	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AYP_RS16920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AYP_RS16930	COG2969	positive regulation of protein catabolic process
AYP_RS16950	COG1960	acyl-CoA dehydrogenase activity
AYP_RS16955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AYP_RS16970	COG1309	transcriptional regulator
AYP_RS16975	COG1960	acyl-CoA dehydrogenase activity
AYP_RS17020	COG1183	phosphatidylcholine synthase activity
AYP_RS17025	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AYP_RS17060	COG0741	lytic transglycosylase activity
AYP_RS17060	COG0739	heme binding
AYP_RS17060	COG1196	nuclear chromosome segregation
AYP_RS17070	COG1702	phosphate starvation-inducible protein PhoH
AYP_RS17105	COG1295	ribonuclease BN
AYP_RS17110	COG0697	spore germination
AYP_RS17115	COG2169	Transcriptional regulator
AYP_RS17120	COG0179	Fumarylacetoacetate (FAA) hydrolase
AYP_RS17165	COG0557	exoribonuclease II activity
AYP_RS17170	COG0339	signal peptide processing
AYP_RS17175	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AYP_RS17205	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AYP_RS17210	COG1960	acyl-CoA dehydrogenase activity
AYP_RS17365	COG0626	cystathionine gamma-synthase activity
AYP_RS17370	COG0433	COG0433 Predicted ATPase
AYP_RS17375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYP_RS17375	COG1017	nitric oxide dioxygenase activity
AYP_RS17380	COG1959	2 iron, 2 sulfur cluster binding
AYP_RS17395	COG1301	dicarboxylic acid transport
AYP_RS17400	COG1946	Acyl-CoA thioesterase
AYP_RS17420	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AYP_RS17425	COG1040	competence protein
AYP_RS17430	COG0494	nUDIX hydrolase
AYP_RS17440	COG0598	Magnesium transport protein CorA
AYP_RS17450	COG2854	intermembrane phospholipid transfer
AYP_RS17460	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AYP_RS17465	COG1127	ABC transporter
AYP_RS17470	COG0513	Belongs to the DEAD box helicase family
AYP_RS17490	COG0408	coproporphyrinogen oxidase activity
AYP_RS17505	COG1960	acyl-CoA dehydrogenase activity
AYP_RS17515	COG1983	PspC domain protein
AYP_RS17520	COG0517	IMP dehydrogenase activity
AYP_RS17565	COG0583	DNA-binding transcription factor activity
AYP_RS17605	COG1012	belongs to the aldehyde dehydrogenase family
AYP_RS17615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AYP_RS17620	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AYP_RS17625	COG0833	amino acid
AYP_RS17655	COG1192	Involved in chromosome partitioning
AYP_RS17660	COG0628	permease
AYP_RS17670	COG1289	transmembrane transporter activity
AYP_RS17685	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYP_RS17690	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AYP_RS17700	COG0277	FAD linked oxidase domain protein
AYP_RS17705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AYP_RS17730	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AYP_RS17735	COG5380	lipid catabolic process
AYP_RS17755	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AYP_RS17805	COG0194	GDP metabolic process
AYP_RS17815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AYP_RS17835	COG3307	-O-antigen
AYP_RS17855	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AYP_RS17860	COG1704	LemA family
AYP_RS17870	COG0493	'glutamate synthase
AYP_RS17875	COG0067	glutamate synthase
AYP_RS17875	COG0069	glutamate synthase activity
AYP_RS17875	COG0070	glutamate synthase
AYP_RS17925	COG2226	methyltransferase
AYP_RS17940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AYP_RS17945	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AYP_RS17990	COG0833	amino acid
AYP_RS18075	COG0488	(ABC) transporter
AYP_RS18080	COG2873	o-acetylhomoserine
AYP_RS18085	COG4221	oxidoreductase activity
AYP_RS18090	COG0659	secondary active sulfate transmembrane transporter activity
AYP_RS18115	COG0427	acetyl-CoA hydrolase
AYP_RS18145	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AYP_RS18175	COG2329	Antibiotic biosynthesis monooxygenase
AYP_RS18190	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AYP_RS18255	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYP_RS18265	COG1733	regulation of RNA biosynthetic process
AYP_RS18300	COG0667	Aldo Keto reductase
AYP_RS18320	COG0583	DNA-binding transcription factor activity
AYP_RS18325	COG2814	Major facilitator Superfamily
AYP_RS18355	COG1335	isochorismatase
AYP_RS18365	COG1012	belongs to the aldehyde dehydrogenase family
AYP_RS18370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AYP_RS18380	COG1113	amino acid transport
AYP_RS18390	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AYP_RS18405	COG2814	Major facilitator Superfamily
AYP_RS18415	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AYP_RS18415	COG0351	phosphomethylpyrimidine kinase
AYP_RS18415	COG0352	thiamine-phosphate diphosphorylase activity
AYP_RS18435	COG1309	transcriptional regulator
AYP_RS18440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AYP_RS18460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYP_RS18470	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AYP_RS18475	COG3162	membrane
AYP_RS18480	COG0784	Response regulator, receiver
AYP_RS18480	COG2198	Histidine kinase
AYP_RS18480	COG2205	protein histidine kinase activity
AYP_RS18505	COG3328	transposase activity
AYP_RS18510	COG1522	sequence-specific DNA binding
AYP_RS18515	COG1335	isochorismatase
AYP_RS18520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYP_RS18530	COG0668	transmembrane transport
AYP_RS18535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AYP_RS18540	COG1519	Transferase
AYP_RS18545	COG1902	pentaerythritol trinitrate reductase activity
AYP_RS18565	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AYP_RS18590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYP_RS18590	COG0426	domain, Protein
AYP_RS18595	COG4774	siderophore transport
AYP_RS18600	COG2119	membrane
AYP_RS18610	COG0508	dehydrogenase complex catalyzes the overall conversion of
AYP_RS18620	COG4942	peptidase
AYP_RS18635	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AYP_RS18645	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AYP_RS18665	COG0189	ligase activity
AYP_RS18685	COG0708	Exodeoxyribonuclease III
AYP_RS18690	COG1393	Belongs to the ArsC family
AYP_RS18705	COG3706	GGDEF domain
AYP_RS18740	COG2351	hydroxyisourate hydrolase activity
AYP_RS18745	COG2233	PERMEase
AYP_RS18755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYP_RS18765	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AYP_RS18770	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_RS18780	COG3150	esterase
AYP_RS18795	COG1388	LysM domain
AYP_RS18795	COG0791	NLP P60 protein
AYP_RS18810	COG2918	glutathione biosynthetic process
AYP_RS18825	COG2733	membrane
AYP_RS18830	COG0436	Aminotransferase
AYP_RS18835	COG0534	Mate efflux family protein
AYP_RS18940	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AYP_RS18945	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AYP_RS18955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AYP_RS18960	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AYP_RS18975	COG0010	Belongs to the arginase family
AYP_RS19005	COG2188	Transcriptional regulator
AYP_RS19015	COG0523	cobalamin synthesis protein
AYP_RS19025	COG1113	amino acid transport
AYP_RS19035	COG0625	glutathione transferase activity
AYP_RS19055	COG1683	Conserved Protein
AYP_RS19060	COG0534	Mate efflux family protein
AYP_RS19065	COG0385	Bile acid
AYP_RS19070	COG1335	isochorismatase
AYP_RS19075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYP_RS19095	COG2116	formate transmembrane transporter activity
AYP_RS19100	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AYP_RS19105	COG2133	pyrroloquinoline quinone binding
AYP_RS19110	COG2983	Belongs to the UPF0260 family
AYP_RS19130	COG1194	a g-specific adenine glycosylase
AYP_RS19145	COG2818	Glycosylase
AYP_RS19150	COG1064	alcohol dehydrogenase
AYP_RS19155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYP_RS19170	COG0583	DNA-binding transcription factor activity
AYP_RS19175	COG0656	L-ascorbic acid biosynthetic process
AYP_RS19180	COG2814	Major facilitator Superfamily
AYP_RS19215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYP_RS19230	COG2233	PERMEase
AYP_RS19270	COG0733	neurotransmitter:sodium symporter activity
AYP_RS19310	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AYP_RS19315	COG0657	acetylesterase activity
AYP_RS19365	COG2951	lytic endotransglycosylase activity
AYP_RS19370	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AYP_RS19390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AYP_RS19400	COG0671	phosphoesterase, PA-phosphatase related
AYP_RS19405	COG0861	Integral membrane protein TerC family
AYP_RS19415	COG0754	glutathionylspermidine amidase activity
AYP_RS19425	COG0402	S-adenosylhomocysteine deaminase activity
AYP_RS19440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AYP_RS19445	COG1230	cation diffusion facilitator family transporter
AYP_RS19460	COG0706	membrane insertase activity
AYP_RS19565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AYP_RS19585	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AYP_RS19670	COG1063	alcohol dehydrogenase
AYP_RS19695	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AYP_RS19705	COG1979	alcohol dehydrogenase
AYP_RS19715	COG1902	pentaerythritol trinitrate reductase activity
AYP_RS19725	COG1309	transcriptional regulator
AYP_RS19735	COG2130	NADP-dependent
AYP_RS19780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AYP_RS19815	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AYP_RS19820	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AYP_RS19820	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AYP_RS19875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AYP_RS19875	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AYP_RS19890	COG0587	DNA-directed DNA polymerase activity
AYP_RS19935	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AYP_RS19990	COG0358	DNA primase activity